CFL1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.73357530
2immunoglobulin mediated immune response (GO:0016064)6.09207615
3L-fucose catabolic process (GO:0042355)6.07683917
4fucose catabolic process (GO:0019317)6.07683917
5L-fucose metabolic process (GO:0042354)6.07683917
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.84341699
7negative regulation of mast cell activation (GO:0033004)5.25815957
8cytidine deamination (GO:0009972)5.24502692
9cytidine metabolic process (GO:0046087)5.24502692
10cytidine catabolic process (GO:0006216)5.24502692
11Arp2/3 complex-mediated actin nucleation (GO:0034314)5.01828909
12protein deneddylation (GO:0000338)4.98127373
13B cell mediated immunity (GO:0019724)4.89971546
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.86811619
15cullin deneddylation (GO:0010388)4.86008656
16chaperone mediated protein folding requiring cofactor (GO:0051085)4.85292301
17positive thymic T cell selection (GO:0045059)4.77839509
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.46211000
19positive regulation of antigen processing and presentation (GO:0002579)4.43940571
20regulation of antigen processing and presentation (GO:0002577)4.43856212
21fusion of sperm to egg plasma membrane (GO:0007342)4.37961264
22negative thymic T cell selection (GO:0045060)4.34595463
23actin nucleation (GO:0045010)4.34035868
24negative T cell selection (GO:0043383)4.22893821
25mast cell degranulation (GO:0043303)4.10949680
26mast cell activation involved in immune response (GO:0002279)4.10949680
27T cell costimulation (GO:0031295)3.84857501
28positive regulation of interleukin-8 secretion (GO:2000484)3.83308331
29lymphocyte costimulation (GO:0031294)3.79444417
30platelet dense granule organization (GO:0060155)3.70849687
31positive T cell selection (GO:0043368)3.68707875
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.66346056
33mast cell activation (GO:0045576)3.64276488
34negative regulation of actin filament bundle assembly (GO:0032232)3.58010163
35regulation of B cell receptor signaling pathway (GO:0050855)3.43090899
36thymic T cell selection (GO:0045061)3.41904651
37antigen processing and presentation of endogenous antigen (GO:0019883)3.40358766
38negative regulation of B cell apoptotic process (GO:0002903)3.33448088
39interferon-gamma-mediated signaling pathway (GO:0060333)3.30897277
40purine deoxyribonucleotide catabolic process (GO:0009155)3.30106499
41T cell receptor signaling pathway (GO:0050852)3.29886773
42GDP-mannose metabolic process (GO:0019673)3.26386234
43plasma membrane fusion (GO:0045026)3.25533460
44regulation of chronic inflammatory response (GO:0002676)3.21579663
45glutathione biosynthetic process (GO:0006750)3.19630158
46fucose metabolic process (GO:0006004)3.18857144
47negative regulation of viral genome replication (GO:0045071)3.16263517
48regulation of isotype switching to IgG isotypes (GO:0048302)3.15951263
49antigen receptor-mediated signaling pathway (GO:0050851)3.11161321
50regulation of T cell tolerance induction (GO:0002664)3.11032772
51regulation of lamellipodium assembly (GO:0010591)3.09487424
52nonribosomal peptide biosynthetic process (GO:0019184)3.08439974
53fucosylation (GO:0036065)3.08069920
54positive regulation of tolerance induction (GO:0002645)3.04810286
55regulation of activation of Janus kinase activity (GO:0010533)3.03597711
56respiratory burst (GO:0045730)2.95024651
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94946036
58regulation of regulatory T cell differentiation (GO:0045589)2.93951117
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92128001
60positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90614010
61positive regulation of monocyte chemotaxis (GO:0090026)2.87980539
62sulfation (GO:0051923)2.87597020
63regulation of interleukin-8 secretion (GO:2000482)2.86819910
64positive regulation of natural killer cell mediated immunity (GO:0002717)2.84881753
65negative regulation of lymphocyte apoptotic process (GO:0070229)2.83896201
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83080409
67positive regulation of cell killing (GO:0031343)2.81944160
68tyrosine phosphorylation of STAT protein (GO:0007260)2.79546362
69positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77672033
70regulation of cellular amino acid metabolic process (GO:0006521)2.75561576
71response to pheromone (GO:0019236)2.73808071
72negative regulation of T cell apoptotic process (GO:0070233)2.73778513
73phosphorylated carbohydrate dephosphorylation (GO:0046838)2.73257931
74inositol phosphate dephosphorylation (GO:0046855)2.73257931
75negative regulation of calcium ion transport into cytosol (GO:0010523)2.72272635
76regulation of mast cell activation (GO:0033003)2.72107452
77UTP metabolic process (GO:0046051)2.72017727
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70184830
79positive regulation of lamellipodium assembly (GO:0010592)2.69911323
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69649032
81neuronal action potential propagation (GO:0019227)2.69327779
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68912241
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68912241
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68912241
85xenobiotic catabolic process (GO:0042178)2.67516664
86GPI anchor biosynthetic process (GO:0006506)2.67420505
87positive regulation of actin filament polymerization (GO:0030838)2.66657235
88lysosome localization (GO:0032418)2.66319522
89positive regulation of chemokine secretion (GO:0090197)2.65333850
90cellular response to interferon-gamma (GO:0071346)2.64971261
91AMP metabolic process (GO:0046033)2.64677775
92T cell selection (GO:0045058)2.64329496
93positive regulation of T cell migration (GO:2000406)2.64058592
94T cell migration (GO:0072678)2.62127453
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61325151
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61325151
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.61156053
98regulation of tolerance induction (GO:0002643)2.60265294
99leukocyte degranulation (GO:0043299)2.58766300
100macrophage chemotaxis (GO:0048246)2.58726937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.54798299
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.51033919
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.16001644
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10537411
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.77070000
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.66079744
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.62629954
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45729815
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43830081
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.76129632
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61631280
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53433726
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.50587412
14MYB_26560356_Chip-Seq_TH2_Human2.29561996
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29432617
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29067491
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.20446590
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11128649
19CIITA_25753668_ChIP-Seq_RAJI_Human2.08443806
20GATA3_26560356_Chip-Seq_TH2_Human1.99011161
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97580811
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95348314
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88254592
24VDR_23849224_ChIP-Seq_CD4+_Human1.84222518
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.81981143
26GATA3_27048872_Chip-Seq_THYMUS_Human1.81077165
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.80278123
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79066771
29RUNX_20019798_ChIP-Seq_JUKART_Human1.74991625
30FOXP3_21729870_ChIP-Seq_TREG_Human1.74698127
31SPI1_23547873_ChIP-Seq_NB4_Human1.66734695
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58384222
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.58006441
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54883132
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52871310
36IRF1_19129219_ChIP-ChIP_H3396_Human1.51155199
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49358823
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43808329
39ZNF274_21170338_ChIP-Seq_K562_Hela1.40632121
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39824393
41MYB_26560356_Chip-Seq_TH1_Human1.39634945
42SPI1_23127762_ChIP-Seq_K562_Human1.39000886
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38450633
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37640284
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36575973
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36568903
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34882728
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33605862
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32585395
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32561378
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.31529141
52BCL6_27268052_Chip-Seq_Bcells_Human1.27551785
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26160531
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24951295
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.22601557
56MAF_26560356_Chip-Seq_TH1_Human1.21937002
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21570685
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19588930
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.17932848
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17890445
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17058165
62TAF2_19829295_ChIP-Seq_ESCs_Human1.13059324
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12673729
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11866502
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.11246844
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.10372198
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08946256
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.08104267
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08014376
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04678752
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03617609
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03179098
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02010355
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01795463
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00908070
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00636569
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99535637
78UTX_26944678_Chip-Seq_JUKART_Human0.98701222
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98680438
80TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96907311
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96648702
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96145534
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95958559
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94878735
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93883104
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93498201
87TP53_22573176_ChIP-Seq_HFKS_Human0.93213564
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92942725
89ERA_21632823_ChIP-Seq_H3396_Human0.91666062
90P300_27268052_Chip-Seq_Bcells_Human0.91461335
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91327851
92MAF_26560356_Chip-Seq_TH2_Human0.87914561
93MYC_19829295_ChIP-Seq_ESCs_Human0.85723130
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85685048
95E2F1_20622854_ChIP-Seq_HELA_Human0.85143903
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84440150
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.84276595
98ELK1_19687146_ChIP-ChIP_HELA_Human0.83319372
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.83086670
100EGR1_19032775_ChIP-ChIP_M12_Human0.82882943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.94149310
2MP0001835_abnormal_antigen_presentation4.87301355
3MP0002138_abnormal_hepatobiliary_system4.45114636
4MP0009785_altered_susceptibility_to3.48254251
5MP0002166_altered_tumor_susceptibility3.12266233
6MP0002102_abnormal_ear_morphology2.91788497
7MP0005000_abnormal_immune_tolerance2.90556256
8MP0002148_abnormal_hypersensitivity_rea2.74573616
9MP0003724_increased_susceptibility_to2.52269870
10MP0000685_abnormal_immune_system2.50368109
11MP0003806_abnormal_nucleotide_metabolis2.45873346
12MP0001873_stomach_inflammation2.41111700
13MP0005025_abnormal_response_to2.33177684
14MP0003763_abnormal_thymus_physiology2.32941120
15MP0002006_tumorigenesis2.28435329
16MP0002420_abnormal_adaptive_immunity2.15147909
17MP0001800_abnormal_humoral_immune2.12841149
18MP0001819_abnormal_immune_cell2.12419234
19MP0002723_abnormal_immune_serum2.06260960
20MP0002405_respiratory_system_inflammati2.04321020
21MP0005451_abnormal_body_composition2.04110338
22MP0006054_spinal_hemorrhage1.97780445
23MP0009333_abnormal_splenocyte_physiolog1.96787603
24MP0005387_immune_system_phenotype1.86896027
25MP0001790_abnormal_immune_system1.86896027
26MP0002452_abnormal_antigen_presenting1.80960597
27MP0003436_decreased_susceptibility_to1.80036330
28MP0003866_abnormal_defecation1.73783682
29MP0002398_abnormal_bone_marrow1.69167197
30MP0010155_abnormal_intestine_physiology1.67281472
31MP0002419_abnormal_innate_immunity1.64711828
32MP0000465_gastrointestinal_hemorrhage1.62161134
33MP0000716_abnormal_immune_system1.61940310
34MP0001845_abnormal_inflammatory_respons1.56687982
35MP0000689_abnormal_spleen_morphology1.54236670
36MP0002722_abnormal_immune_system1.44065455
37MP0003183_abnormal_peptide_metabolism1.39535919
38MP0006036_abnormal_mitochondrial_physio1.39202102
39MP0009764_decreased_sensitivity_to1.38785668
40MP0002429_abnormal_blood_cell1.36422980
41MP0006082_CNS_inflammation1.32799952
42MP0001764_abnormal_homeostasis1.27284320
43MP0005464_abnormal_platelet_physiology1.25922140
44MP0005377_hearing/vestibular/ear_phenot1.24619253
45MP0003878_abnormal_ear_physiology1.24619253
46MP0000703_abnormal_thymus_morphology1.24363234
47MP0008469_abnormal_protein_level1.22318840
48MP0003195_calcinosis1.21966072
49MP0003448_altered_tumor_morphology1.21884765
50MP0005166_decreased_susceptibility_to1.16919355
51MP0005410_abnormal_fertilization1.16004443
52MP0005075_abnormal_melanosome_morpholog1.15476841
53MP0008872_abnormal_physiological_respon1.10976040
54MP0001533_abnormal_skeleton_physiology1.07277216
55MP0002876_abnormal_thyroid_physiology1.06249837
56MP0002933_joint_inflammation1.05988237
57MP0004147_increased_porphyrin_level1.04877573
58MP0005645_abnormal_hypothalamus_physiol1.02508005
59MP0005332_abnormal_amino_acid1.01385565
60MP0000613_abnormal_salivary_gland1.00847458
61MP0003303_peritoneal_inflammation0.99277965
62MP0005085_abnormal_gallbladder_physiolo0.93950808
63MP0002019_abnormal_tumor_incidence0.91470203
64MP0009763_increased_sensitivity_to0.91131445
65MP0005058_abnormal_lysosome_morphology0.89971324
66MP0004782_abnormal_surfactant_physiolog0.89953698
67MP0008873_increased_physiological_sensi0.89160653
68MP0001663_abnormal_digestive_system0.87587190
69MP0009643_abnormal_urine_homeostasis0.87271159
70MP0009697_abnormal_copulation0.87002247
71MP0001666_abnormal_nutrient_absorption0.86604613
72MP0003693_abnormal_embryo_hatching0.85302108
73MP0008260_abnormal_autophagy0.84670518
74MP0001501_abnormal_sleep_pattern0.83836893
75MP0003045_fibrosis0.83597610
76MP0009840_abnormal_foam_cell0.81229731
77MP0001919_abnormal_reproductive_system0.80864907
78MP0001905_abnormal_dopamine_level0.80283782
79MP0005636_abnormal_mineral_homeostasis0.75828023
80MP0000858_altered_metastatic_potential0.75316615
81MP0006072_abnormal_retinal_apoptosis0.75168156
82MP0008875_abnormal_xenobiotic_pharmacok0.75138574
83MP0001243_abnormal_dermal_layer0.72498004
84MP0003186_abnormal_redox_activity0.70048356
85MP0002277_abnormal_respiratory_mucosa0.67505807
86MP0005365_abnormal_bile_salt0.66406382
87MP0003252_abnormal_bile_duct0.65419789
88MP0004742_abnormal_vestibular_system0.64868813
89MP0001853_heart_inflammation0.64853236
90MP0003075_altered_response_to0.64826876
91MP0005551_abnormal_eye_electrophysiolog0.64306087
92MP0002136_abnormal_kidney_physiology0.61115642
93MP0005084_abnormal_gallbladder_morpholo0.58738323
94MP0001986_abnormal_taste_sensitivity0.58412993
95MP0000490_abnormal_crypts_of0.57946335
96MP0003011_delayed_dark_adaptation0.57159863
97MP0008438_abnormal_cutaneous_collagen0.56056738
98MP0002733_abnormal_thermal_nociception0.56012251
99MP0008995_early_reproductive_senescence0.55494342
100MP0005319_abnormal_enzyme/_coenzyme0.55468221

Predicted human phenotypes

RankGene SetZ-score
1Hypomagnesemia (HP:0002917)5.29894928
2Abnormality of the prostate (HP:0008775)5.27153058
3Prostate neoplasm (HP:0100787)4.98639918
4Abnormality of magnesium homeostasis (HP:0004921)4.67852895
5Increased IgM level (HP:0003496)4.25396563
6Abnormality of T cell number (HP:0011839)3.99144259
7Hypoplasia of the capital femoral epiphysis (HP:0003090)3.93741884
8T lymphocytopenia (HP:0005403)3.80255305
9IgG deficiency (HP:0004315)3.68490337
10Autoimmune hemolytic anemia (HP:0001890)3.67408207
11J-shaped sella turcica (HP:0002680)3.55295030
12Hypoproteinemia (HP:0003075)3.55250134
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.49134574
14Abnormality of T cells (HP:0002843)3.40478553
15Abnormality of male internal genitalia (HP:0000022)3.20097732
16Aplastic anemia (HP:0001915)3.11699911
17Abnormality of B cell number (HP:0010975)3.09732953
18Abnormality of midbrain morphology (HP:0002418)3.09490353
19Molar tooth sign on MRI (HP:0002419)3.09490353
20Pulmonary fibrosis (HP:0002206)3.07901740
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.04104243
22Absent epiphyses (HP:0010577)3.04104243
23Obstructive lung disease (HP:0006536)2.95116299
24Chronic obstructive pulmonary disease (HP:0006510)2.95116299
25Stomach cancer (HP:0012126)2.92116955
26Retinal dysplasia (HP:0007973)2.85867845
27Progressive neurologic deterioration (HP:0002344)2.85045318
28Abolished electroretinogram (ERG) (HP:0000550)2.82068750
29Meningitis (HP:0001287)2.79213492
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77860943
31Increased serum lactate (HP:0002151)2.65283060
32Amyotrophic lateral sclerosis (HP:0007354)2.64076226
33Type 2 muscle fiber atrophy (HP:0003554)2.62218349
34Elevated erythrocyte sedimentation rate (HP:0003565)2.61040546
35Recurrent cutaneous fungal infections (HP:0011370)2.58823385
36Chronic mucocutaneous candidiasis (HP:0002728)2.58823385
37Chronic hepatic failure (HP:0100626)2.58178537
38Pulmonary infiltrates (HP:0002113)2.56802088
39Polyuria (HP:0000103)2.53827405
40Periorbital edema (HP:0100539)2.52294931
41Recurrent bacterial skin infections (HP:0005406)2.49189956
42Abnormality of T cell physiology (HP:0011840)2.48147252
43Hyponatremia (HP:0002902)2.46108999
44IgM deficiency (HP:0002850)2.44957752
45Renal salt wasting (HP:0000127)2.44278203
46Facial edema (HP:0000282)2.42743359
47Alkalosis (HP:0001948)2.42433544
48Hepatocellular necrosis (HP:0001404)2.42400373
49Autoimmune thrombocytopenia (HP:0001973)2.42131143
50Attenuation of retinal blood vessels (HP:0007843)2.41643164
51Delayed CNS myelination (HP:0002188)2.37224674
52Hepatic necrosis (HP:0002605)2.36654365
53Microvesicular hepatic steatosis (HP:0001414)2.34138541
54Recurrent fungal infections (HP:0002841)2.32543731
55Mediastinal lymphadenopathy (HP:0100721)2.32319952
56Infantile muscular hypotonia (HP:0008947)2.29868808
57Muscle fiber atrophy (HP:0100295)2.28173044
58Urticaria (HP:0001025)2.26758222
59Pustule (HP:0200039)2.23593742
60Recurrent abscess formation (HP:0002722)2.22643256
61Encephalitis (HP:0002383)2.16966187
62Absent/shortened dynein arms (HP:0200106)2.14063709
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.14063709
64B lymphocytopenia (HP:0010976)2.13125014
65Ureteral stenosis (HP:0000071)2.12161176
66Abnormal mitochondria in muscle tissue (HP:0008316)2.10785586
67Abnormality of macrophages (HP:0004311)2.10574491
68Chest pain (HP:0100749)2.10532321
69Abnormal urine output (HP:0012590)2.10392578
70Ureteral obstruction (HP:0006000)2.07604627
71Decreased central vision (HP:0007663)2.06631507
72Eosinophilia (HP:0001880)2.04900824
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04546831
74Type I transferrin isoform profile (HP:0003642)2.03977807
75Eczematoid dermatitis (HP:0000976)2.02826319
76Abnormality of eosinophils (HP:0001879)1.99578134
77Elfin facies (HP:0004428)1.99154620
78Lactic acidosis (HP:0003128)1.98041720
79Hypercalciuria (HP:0002150)1.97288033
80Overriding aorta (HP:0002623)1.96768429
81Acute necrotizing encephalopathy (HP:0006965)1.93908488
82Generalized aminoaciduria (HP:0002909)1.93603040
83Increased intramyocellular lipid droplets (HP:0012240)1.93459882
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93080195
85Hemoptysis (HP:0002105)1.92832583
86Recurrent gram-negative bacterial infections (HP:0005420)1.92166370
87Recurrent skin infections (HP:0001581)1.91700662
88Agammaglobulinemia (HP:0004432)1.89594456
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.87998711
90Chronic diarrhea (HP:0002028)1.87171912
91Petechiae (HP:0000967)1.86628627
92Stomatitis (HP:0010280)1.86375417
93Vasculitis (HP:0002633)1.85156440
94Agitation (HP:0000713)1.84990079
95Lymphopenia (HP:0001888)1.84946155
96Mitochondrial inheritance (HP:0001427)1.84823035
97Acute hepatic failure (HP:0006554)1.84722293
98Recurrent viral infections (HP:0004429)1.84705694
99Renovascular hypertension (HP:0100817)1.83406225
100Abnormality of the pleura (HP:0002103)1.83034102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.56615838
2SCYL24.72205193
3TESK24.52314168
4TLK14.46847813
5ZAK4.31943934
6KIT3.63726267
7MAP4K13.23910328
8FES2.68325580
9FER2.18814927
10TXK2.11726998
11SYK2.08159075
12CDK82.00364822
13TESK11.85343693
14GRK11.71129582
15MAP4K21.68160290
16TAOK31.64869480
17ITK1.62602598
18TBK11.56627339
19VRK21.55066980
20CSF1R1.42719678
21IKBKE1.42505671
22LIMK11.38438784
23GRK61.34123858
24PINK11.30776063
25MAPKAPK31.24926643
26MST41.23628916
27ADRBK21.17434845
28TEC1.15334590
29LYN1.11813780
30RPS6KA41.11542160
31PHKG21.09287423
32PHKG11.09287423
33MAP3K111.09226082
34PDK20.98596430
35CSK0.97708446
36LCK0.93003493
37MAP3K120.90264982
38VRK10.89808006
39TNK20.89495122
40JAK30.86569849
41ATR0.84798239
42ZAP700.83808512
43NME10.81413040
44RIPK40.80325180
45IKBKB0.79506578
46PIK3CG0.78060169
47DAPK20.76814595
48FLT30.76184099
49TYRO30.75735628
50IRAK40.75341433
51BTK0.70372599
52PRKCQ0.67881082
53BMPR1B0.66933862
54PIK3CA0.66652311
55BCKDK0.65277930
56BRSK20.64958580
57CDK40.61542927
58BLK0.59098402
59SIK30.58479982
60DAPK10.54842106
61WNK30.53980330
62RPS6KA50.53450379
63CAMKK10.51534731
64MAPK130.51198210
65PIM10.50457419
66MATK0.43768136
67ABL10.43409546
68CDK30.40899484
69IGF1R0.40571924
70NUAK10.40139080
71WNK40.38950894
72PRKCA0.38564998
73MYLK0.38533626
74GRK70.38484662
75CAMKK20.37104248
76HCK0.32914283
77INSRR0.31568462
78MAP2K20.31563860
79PIM20.29755566
80CDK90.28483157
81MAPKAPK20.27909295
82MAP3K50.27544222
83BMPR20.25368366
84PRKCI0.24353437
85AURKA0.23834454
86GRK50.23789854
87OXSR10.23778189
88MAP2K60.22904409
89MAPKAPK50.22248827
90TRPM70.21793140
91PRKCD0.21402561
92CDK190.21314477
93INSR0.20944881
94ADRBK10.19802184
95FYN0.17289595
96ERN10.16555220
97CSNK2A10.16439282
98PRKACA0.16253898
99BRSK10.16246036
100ATM0.14973209

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.79091557
2Allograft rejection_Homo sapiens_hsa053304.72037453
3Asthma_Homo sapiens_hsa053104.67896917
4Autoimmune thyroid disease_Homo sapiens_hsa053204.41203271
5Type I diabetes mellitus_Homo sapiens_hsa049403.90751038
6Antigen processing and presentation_Homo sapiens_hsa046123.79490313
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.45444708
8Proteasome_Homo sapiens_hsa030503.25125287
9Primary immunodeficiency_Homo sapiens_hsa053402.72028305
10Staphylococcus aureus infection_Homo sapiens_hsa051502.58025298
11Viral myocarditis_Homo sapiens_hsa054162.42164134
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36237209
13Leishmaniasis_Homo sapiens_hsa051402.21473421
14Rheumatoid arthritis_Homo sapiens_hsa053232.21145455
15Hematopoietic cell lineage_Homo sapiens_hsa046401.97768508
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69169364
17Sulfur metabolism_Homo sapiens_hsa009201.54576228
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48937453
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44960802
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35029465
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25963751
22Parkinsons disease_Homo sapiens_hsa050121.25061550
23Oxidative phosphorylation_Homo sapiens_hsa001901.22620931
24Systemic lupus erythematosus_Homo sapiens_hsa053221.21734601
25Pyruvate metabolism_Homo sapiens_hsa006201.17407327
26Herpes simplex infection_Homo sapiens_hsa051681.10112878
27Tuberculosis_Homo sapiens_hsa051521.04240006
28DNA replication_Homo sapiens_hsa030300.98340429
29T cell receptor signaling pathway_Homo sapiens_hsa046600.96486357
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94186210
31RNA polymerase_Homo sapiens_hsa030200.88872694
32Linoleic acid metabolism_Homo sapiens_hsa005910.85891873
33Malaria_Homo sapiens_hsa051440.80135403
34Legionellosis_Homo sapiens_hsa051340.79904441
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76832532
36Phagosome_Homo sapiens_hsa041450.74424467
37Influenza A_Homo sapiens_hsa051640.73691590
38Salmonella infection_Homo sapiens_hsa051320.71828131
39Toxoplasmosis_Homo sapiens_hsa051450.70552628
40Arachidonic acid metabolism_Homo sapiens_hsa005900.65837605
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64744090
42Nucleotide excision repair_Homo sapiens_hsa034200.63713149
43Butanoate metabolism_Homo sapiens_hsa006500.62062428
44Ether lipid metabolism_Homo sapiens_hsa005650.61611228
45Mismatch repair_Homo sapiens_hsa034300.60480450
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59592882
47Alzheimers disease_Homo sapiens_hsa050100.59013597
48Selenocompound metabolism_Homo sapiens_hsa004500.58673634
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58463938
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57622356
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55253143
52Base excision repair_Homo sapiens_hsa034100.55107319
53Shigellosis_Homo sapiens_hsa051310.54971883
54Pertussis_Homo sapiens_hsa051330.54895561
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50472913
56Huntingtons disease_Homo sapiens_hsa050160.49645659
57Measles_Homo sapiens_hsa051620.49258102
58Purine metabolism_Homo sapiens_hsa002300.46227063
59Caffeine metabolism_Homo sapiens_hsa002320.45819119
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44709958
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43968493
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42935347
63Folate biosynthesis_Homo sapiens_hsa007900.41129656
64Epstein-Barr virus infection_Homo sapiens_hsa051690.41083649
65RNA degradation_Homo sapiens_hsa030180.41053855
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40589840
67Phototransduction_Homo sapiens_hsa047440.39524804
68Protein export_Homo sapiens_hsa030600.38999608
69Collecting duct acid secretion_Homo sapiens_hsa049660.38560982
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.36384562
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.36319478
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.32315433
73Peroxisome_Homo sapiens_hsa041460.32235940
74Fanconi anemia pathway_Homo sapiens_hsa034600.30966618
75HTLV-I infection_Homo sapiens_hsa051660.29012719
76Fructose and mannose metabolism_Homo sapiens_hsa000510.28641316
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28426653
78One carbon pool by folate_Homo sapiens_hsa006700.28385794
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26881455
80Propanoate metabolism_Homo sapiens_hsa006400.25929946
81Pyrimidine metabolism_Homo sapiens_hsa002400.25498605
82Regulation of autophagy_Homo sapiens_hsa041400.23956620
83Chemical carcinogenesis_Homo sapiens_hsa052040.22663817
84Fat digestion and absorption_Homo sapiens_hsa049750.22499117
85Fatty acid elongation_Homo sapiens_hsa000620.22475131
86Fatty acid degradation_Homo sapiens_hsa000710.21309528
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20654779
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18494721
89ABC transporters_Homo sapiens_hsa020100.18470384
90African trypanosomiasis_Homo sapiens_hsa051430.18465410
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17552048
92Platelet activation_Homo sapiens_hsa046110.16571031
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16024007
94Metabolic pathways_Homo sapiens_hsa011000.15145413
95Tryptophan metabolism_Homo sapiens_hsa003800.14045213
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13283223
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.12564762
98Fatty acid metabolism_Homo sapiens_hsa012120.11662936
99Retinol metabolism_Homo sapiens_hsa008300.11347499
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11037873

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