CFL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.18698181
2axon ensheathment in central nervous system (GO:0032291)6.18698181
3response to muscle activity (GO:0014850)5.08370191
4actin-myosin filament sliding (GO:0033275)4.87918148
5muscle filament sliding (GO:0030049)4.87918148
6fatty acid elongation (GO:0030497)4.31091362
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.30513474
8actin-mediated cell contraction (GO:0070252)4.21824209
9negative regulation of protein localization to cell surface (GO:2000009)4.20404950
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07153288
11establishment of mitochondrion localization (GO:0051654)4.06769869
12axon ensheathment (GO:0008366)4.04958745
13ensheathment of neurons (GO:0007272)4.04958745
14myelination (GO:0042552)4.04310505
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90545096
16heart process (GO:0003015)3.84145921
17heart contraction (GO:0060047)3.84145921
18regulation of skeletal muscle contraction (GO:0014819)3.83378870
19creatine metabolic process (GO:0006600)3.82769518
20cardiac cell development (GO:0055006)3.76284858
21regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.75424236
22sarcoplasmic reticulum calcium ion transport (GO:0070296)3.75174544
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74288085
24ATP synthesis coupled proton transport (GO:0015986)3.74288085
25regulation of cell communication by electrical coupling (GO:0010649)3.72806394
26cardiac muscle hypertrophy (GO:0003300)3.72480279
27skeletal muscle fiber development (GO:0048741)3.70884316
28muscle system process (GO:0003012)3.65741833
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.64574224
30myotube cell development (GO:0014904)3.64125145
31* muscle cell cellular homeostasis (GO:0046716)3.59102320
32regulation of the force of heart contraction (GO:0002026)3.57018024
33substantia nigra development (GO:0021762)3.55150355
34long-chain fatty acid biosynthetic process (GO:0042759)3.54471263
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.53895838
36striated muscle hypertrophy (GO:0014897)3.53894978
37skeletal muscle tissue development (GO:0007519)3.51434838
38muscle fiber development (GO:0048747)3.50802910
39muscle cell fate commitment (GO:0042693)3.50662195
40* sarcomere organization (GO:0045214)3.43620834
41plasma membrane repair (GO:0001778)3.43042493
42regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.39692957
43respiratory electron transport chain (GO:0022904)3.37686333
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36468212
45myofibril assembly (GO:0030239)3.28339807
46regulation of relaxation of muscle (GO:1901077)3.28127138
47striated muscle cell development (GO:0055002)3.27662422
48electron transport chain (GO:0022900)3.27151168
49cholesterol biosynthetic process (GO:0006695)3.25159725
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15512970
51positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.13755739
52adult heart development (GO:0007512)3.13488033
53muscle structure development (GO:0061061)3.12976334
54muscle organ development (GO:0007517)3.10512209
55actin filament-based movement (GO:0030048)3.07453402
56skeletal muscle contraction (GO:0003009)3.06134723
57pyrimidine nucleobase catabolic process (GO:0006208)3.04056293
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00588401
59photoreceptor cell differentiation (GO:0046530)2.99422945
60eye photoreceptor cell differentiation (GO:0001754)2.99422945
61cardiac myofibril assembly (GO:0055003)2.99176176
62response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.98970591
63regulation of collateral sprouting (GO:0048670)2.97386309
64apical protein localization (GO:0045176)2.97003136
65muscle hypertrophy (GO:0014896)2.96181506
66skeletal muscle adaptation (GO:0043501)2.95240209
67regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92928483
68myelin maintenance (GO:0043217)2.92069878
69protein neddylation (GO:0045116)2.91979632
70negative regulation of calcium ion transmembrane transport (GO:1903170)2.91908970
71negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.91908970
72cerebral cortex radially oriented cell migration (GO:0021799)2.91884814
73limb bud formation (GO:0060174)2.91070067
74striated muscle adaptation (GO:0014888)2.89892206
75sterol biosynthetic process (GO:0016126)2.89267541
76mitochondrion transport along microtubule (GO:0047497)2.89079837
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89079837
78glucan biosynthetic process (GO:0009250)2.87702938
79glycogen biosynthetic process (GO:0005978)2.87702938
80asymmetric protein localization (GO:0008105)2.87519014
81glycogen catabolic process (GO:0005980)2.87048999
82regulation of calcium ion transmembrane transporter activity (GO:1901019)2.85235272
83regulation of calcium ion transmembrane transport (GO:1903169)2.85235272
84chaperone-mediated protein transport (GO:0072321)2.83902147
85peripheral nervous system axon ensheathment (GO:0032292)2.79849685
86myelination in peripheral nervous system (GO:0022011)2.79849685
87regulation of muscle system process (GO:0090257)2.78271530
88regulation of actin filament-based movement (GO:1903115)2.77460310
89regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77453547
90muscle cell development (GO:0055001)2.76742564
91myoblast fusion (GO:0007520)2.75087806
92neuron cell-cell adhesion (GO:0007158)2.73900698
93striated muscle tissue development (GO:0014706)2.73459873
94negative regulation of neurotransmitter secretion (GO:0046929)2.72994371
95cell migration in hindbrain (GO:0021535)2.72321378
96relaxation of muscle (GO:0090075)2.71503281
97neuronal action potential propagation (GO:0019227)2.70907161
98negative regulation of neurotransmitter transport (GO:0051589)2.70758199
99regulation of muscle contraction (GO:0006937)2.70637060
100astrocyte development (GO:0014002)2.69831647
101regulation of membrane repolarization (GO:0060306)2.68566103
102glycerophospholipid catabolic process (GO:0046475)2.68320264
103ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.67257129
104positive regulation of myoblast differentiation (GO:0045663)2.65311785
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.64727715
106striated muscle contraction (GO:0006941)2.63437183
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.63161501
108regulation of sarcomere organization (GO:0060297)2.60760454
109oligodendrocyte differentiation (GO:0048709)2.58709808
110lipid particle organization (GO:0034389)2.58356030
111regulation of ATPase activity (GO:0043462)2.57571769
112regulation of ATP catabolic process (GO:1903289)2.57571769
113neuromuscular synaptic transmission (GO:0007274)2.56851808
114detection of calcium ion (GO:0005513)2.56726592
115glucan catabolic process (GO:0009251)2.56053592
116muscle tissue development (GO:0060537)2.56051876
117response to redox state (GO:0051775)2.54761191
118cardiac muscle hypertrophy in response to stress (GO:0014898)2.54371352
119muscle hypertrophy in response to stress (GO:0003299)2.54371352
120cardiac muscle adaptation (GO:0014887)2.54371352
121NADH metabolic process (GO:0006734)2.53725777
122regulation of potassium ion transmembrane transporter activity (GO:1901016)2.53632243
123cardiac muscle tissue morphogenesis (GO:0055008)2.53581476
124regulation of myoblast differentiation (GO:0045661)2.53532677
125* actomyosin structure organization (GO:0031032)2.53359919
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52415940
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51969329
128presynaptic membrane organization (GO:0097090)2.51812795
129regulation of striated muscle contraction (GO:0006942)2.50418731
130regulation of cardiac muscle contraction (GO:0055117)2.50216711
131membrane assembly (GO:0071709)2.50124516
132neural nucleus development (GO:0048857)2.49720967
133neuron recognition (GO:0008038)2.48683858
134dendrite morphogenesis (GO:0048813)2.47888323
135cardiac muscle cell development (GO:0055013)2.47706470
136tricarboxylic acid cycle (GO:0006099)2.46985664
137positive regulation of action potential (GO:0045760)2.46947982
138skeletal muscle tissue regeneration (GO:0043403)2.46774375
139striated muscle atrophy (GO:0014891)2.46204883
140relaxation of cardiac muscle (GO:0055119)2.44763913
141muscle tissue morphogenesis (GO:0060415)2.43788234
142myotube differentiation (GO:0014902)2.42911247
143presynaptic membrane assembly (GO:0097105)2.42864361
144positive regulation of cation channel activity (GO:2001259)2.42637570
145response to activity (GO:0014823)2.42555101
146response to caffeine (GO:0031000)2.42436671
147cellular response to epinephrine stimulus (GO:0071872)2.41844494
148negative regulation of axonogenesis (GO:0050771)2.41836349
149positive regulation of potassium ion transport (GO:0043268)2.41256820
150short-term memory (GO:0007614)2.40758620
151muscle contraction (GO:0006936)2.40451885
152response to epinephrine (GO:0071871)2.40266130
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.40021100
154muscle atrophy (GO:0014889)2.39444400
155response to inactivity (GO:0014854)2.37911262
156cardiac muscle contraction (GO:0060048)2.37527438
157negative regulation of JUN kinase activity (GO:0043508)2.36097364
158neuromuscular junction development (GO:0007528)2.35422574
159regulation of coenzyme metabolic process (GO:0051196)2.35003379
160regulation of cofactor metabolic process (GO:0051193)2.35003379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.96629551
2GBX2_23144817_ChIP-Seq_PC3_Human2.82187205
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52872506
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32082213
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.29153442
6* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.28453771
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26527242
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.14913037
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13594473
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11334539
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11334539
12TAF15_26573619_Chip-Seq_HEK293_Human2.10152181
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07607055
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.07056413
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01488281
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.95103531
17AR_21572438_ChIP-Seq_LNCaP_Human1.91494734
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91042177
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87222796
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86417759
21IGF1R_20145208_ChIP-Seq_DFB_Human1.83483998
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.82165832
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.80506988
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.80368039
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79869761
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.79476432
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.79250448
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78399758
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78258507
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75238296
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72946682
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71514634
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71440222
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67604450
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66822155
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61154734
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60467905
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.58960085
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57883416
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54045840
41VDR_22108803_ChIP-Seq_LS180_Human1.53897328
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53684459
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53205752
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.52080047
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51823568
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.51700468
47* ER_23166858_ChIP-Seq_MCF-7_Human1.51697986
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51402632
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51035605
50BRD4_25478319_ChIP-Seq_HGPS_Human1.47370758
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47242145
52* ZNF274_21170338_ChIP-Seq_K562_Hela1.45739546
53FUS_26573619_Chip-Seq_HEK293_Human1.44699986
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.43828568
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.43710343
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42509686
57* SALL1_21062744_ChIP-ChIP_HESCs_Human1.41440680
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39313520
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39013926
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39013926
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36531514
62P300_19829295_ChIP-Seq_ESCs_Human1.34734102
63* CRX_20693478_ChIP-Seq_RETINA_Mouse1.31785807
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30641820
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.29537708
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.29537708
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25717910
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25550700
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24058824
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24030058
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23473349
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23045022
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21454062
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.20839495
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20426508
76SMAD4_21799915_ChIP-Seq_A2780_Human1.19186802
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18235065
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18088497
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16496679
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.15812873
81GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15810949
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15567765
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15514911
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.14479720
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13392028
86RNF2_27304074_Chip-Seq_NSC_Mouse1.12755041
87TP53_16413492_ChIP-PET_HCT116_Human1.12501878
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11590313
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10756497
90P53_22387025_ChIP-Seq_ESCs_Mouse1.09723897
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09456426
92TCF4_23295773_ChIP-Seq_U87_Human1.08794293
93* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07348116
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06860376
95CBP_20019798_ChIP-Seq_JUKART_Human1.06860376
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05711469
97EWS_26573619_Chip-Seq_HEK293_Human1.04586973
98BCAT_22108803_ChIP-Seq_LS180_Human1.03289918
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.02616553
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01776476
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01631992
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01287648
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01281626
104TP53_18474530_ChIP-ChIP_U2OS_Human1.01243556
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00427160
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.00133635
107STAT3_23295773_ChIP-Seq_U87_Human0.99531106
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98415826
109* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97972439
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96879710
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95867213
112REST_21632747_ChIP-Seq_MESCs_Mouse0.95728765
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95249366
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.95005564
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94422947
116* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93615506
117NANOG_19829295_ChIP-Seq_ESCs_Human0.93580185
118SOX2_19829295_ChIP-Seq_ESCs_Human0.93580185
119JUN_21703547_ChIP-Seq_K562_Human0.92370219
120AHR_22903824_ChIP-Seq_MCF-7_Human0.92186112
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92041976
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.91262642
123AR_25329375_ChIP-Seq_VCAP_Human0.91103703
124DROSHA_22980978_ChIP-Seq_HELA_Human0.90949944
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90245083
126REST_18959480_ChIP-ChIP_MESCs_Mouse0.90062725
127EOMES_21245162_ChIP-Seq_HESCs_Human0.89808933
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89276252
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88741066
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88004101
131* CJUN_26792858_Chip-Seq_BT549_Human0.87552621
132SOX9_26525672_Chip-Seq_HEART_Mouse0.86485299
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86291531
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85979928
135HTT_18923047_ChIP-ChIP_STHdh_Human0.85502807
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85497521
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85496656
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84788641
139RUNX2_22187159_ChIP-Seq_PCA_Human0.84737934
140RING1B_27294783_Chip-Seq_NPCs_Mouse0.84720441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.58237473
2MP0000749_muscle_degeneration3.34041089
3MP0004145_abnormal_muscle_electrophysio3.33928666
4MP0004270_analgesia3.04932054
5MP0002837_dystrophic_cardiac_calcinosis3.02781503
6MP0004036_abnormal_muscle_relaxation2.66367836
7MP0003950_abnormal_plasma_membrane2.51070529
8MP0000747_muscle_weakness2.47268331
9MP0004084_abnormal_cardiac_muscle2.40197410
10MP0000920_abnormal_myelination2.34900435
11MP0009780_abnormal_chondrocyte_physiolo2.31446959
12MP0003880_abnormal_central_pattern2.27425833
13MP0003646_muscle_fatigue2.18583471
14MP0004215_abnormal_myocardial_fiber1.96399930
15MP0005620_abnormal_muscle_contractility1.94962785
16MP0002106_abnormal_muscle_physiology1.94021764
17MP0004087_abnormal_muscle_fiber1.90044983
18MP0001529_abnormal_vocalization1.87121515
19MP0005330_cardiomyopathy1.85671142
20MP0000778_abnormal_nervous_system1.79677545
21MP0000759_abnormal_skeletal_muscle1.78874631
22MP0002734_abnormal_mechanical_nocicepti1.77163003
23MP0005369_muscle_phenotype1.76893998
24MP0003137_abnormal_impulse_conducting1.70692677
25MP0005171_absent_coat_pigmentation1.68732060
26MP0000750_abnormal_muscle_regeneration1.66078525
27MP0002972_abnormal_cardiac_muscle1.64649127
28MP0002269_muscular_atrophy1.62026512
29MP0001299_abnormal_eye_distance/1.60913667
30MP0006276_abnormal_autonomic_nervous1.56292666
31MP0005623_abnormal_meninges_morphology1.47713371
32MP0001905_abnormal_dopamine_level1.45157488
33MP0008438_abnormal_cutaneous_collagen1.42739497
34MP0003329_amyloid_beta_deposits1.40136000
35MP0004142_abnormal_muscle_tone1.39307611
36MP0004233_abnormal_muscle_weight1.37466066
37MP0004859_abnormal_synaptic_plasticity1.34139371
38MP0010368_abnormal_lymphatic_system1.33619827
39MP0002127_abnormal_cardiovascular_syste1.33364612
40MP0002272_abnormal_nervous_system1.32874186
41MP0002108_abnormal_muscle_morphology1.32770985
42MP0004130_abnormal_muscle_cell1.32095350
43MP0004484_altered_response_of1.30311273
44MP0009250_abnormal_appendicular_skeleto1.30100101
45MP0008775_abnormal_heart_ventricle1.28170288
46MP0001440_abnormal_grooming_behavior1.27672980
47MP0004085_abnormal_heartbeat1.26744234
48MP0001486_abnormal_startle_reflex1.23936592
49MP0002735_abnormal_chemical_nociception1.23155513
50MP0003634_abnormal_glial_cell1.21868921
51MP0003221_abnormal_cardiomyocyte_apopto1.21841059
52MP0003635_abnormal_synaptic_transmissio1.17105105
53MP0009046_muscle_twitch1.16271136
54MP0000013_abnormal_adipose_tissue1.16093543
55MP0000955_abnormal_spinal_cord1.14831907
56MP0002064_seizures1.13946930
57MP0006138_congestive_heart_failure1.13573685
58MP0002184_abnormal_innervation1.12088880
59MP0004134_abnormal_chest_morphology1.11215097
60MP0003279_aneurysm1.11145050
61MP0001661_extended_life_span1.10803117
62MP0001485_abnormal_pinna_reflex1.09526354
63MP0004742_abnormal_vestibular_system1.08288557
64MP0004510_myositis1.08284170
65MP0003122_maternal_imprinting1.05078107
66MP0004272_abnormal_basement_membrane1.03708584
67MP0005386_behavior/neurological_phenoty1.03296404
68MP0004924_abnormal_behavior1.03296404
69MP0005423_abnormal_somatic_nervous1.02425273
70MP0004885_abnormal_endolymph1.01577396
71MP0002234_abnormal_pharynx_morphology1.01556289
72MP0002882_abnormal_neuron_morphology0.99990158
73MP0000733_abnormal_muscle_development0.99783614
74MP0005503_abnormal_tendon_morphology0.98829165
75MP0004147_increased_porphyrin_level0.98758970
76MP0005187_abnormal_penis_morphology0.98263846
77MP0005451_abnormal_body_composition0.97947905
78MP0006036_abnormal_mitochondrial_physio0.96610661
79MP0005385_cardiovascular_system_phenoty0.96532936
80MP0001544_abnormal_cardiovascular_syste0.96532936
81MP0002332_abnormal_exercise_endurance0.96500586
82MP0002067_abnormal_sensory_capabilities0.96191859
83MP0001970_abnormal_pain_threshold0.95100738
84MP0009745_abnormal_behavioral_response0.94557819
85MP0002733_abnormal_thermal_nociception0.93093150
86MP0002063_abnormal_learning/memory/cond0.92601587
87MP0003385_abnormal_body_wall0.92289509
88MP0002066_abnormal_motor_capabilities/c0.91607021
89MP0005266_abnormal_metabolism0.90275077
90MP0004043_abnormal_pH_regulation0.89893201
91MP0002752_abnormal_somatic_nervous0.89338004
92MP0002229_neurodegeneration0.88780735
93MP0003690_abnormal_glial_cell0.88612231
94MP0010630_abnormal_cardiac_muscle0.87763486
95MP0000762_abnormal_tongue_morphology0.87687069
96MP0003705_abnormal_hypodermis_morpholog0.87535848
97MP0003937_abnormal_limbs/digits/tail_de0.86545142
98MP0009384_cardiac_valve_regurgitation0.86457982
99MP0000003_abnormal_adipose_tissue0.85769193
100MP0002572_abnormal_emotion/affect_behav0.82254114
101MP0003136_yellow_coat_color0.82200516
102MP0001958_emphysema0.80763538
103MP0001968_abnormal_touch/_nociception0.78058204
104MP0000462_abnormal_digestive_system0.78028263
105MP0000537_abnormal_urethra_morphology0.77922923
106MP0001542_abnormal_bone_strength0.76038312
107MP0002102_abnormal_ear_morphology0.74952262
108MP0009697_abnormal_copulation0.73677377
109MP0002971_abnormal_brown_adipose0.73523220
110MP0003632_abnormal_nervous_system0.73502541
111MP0003941_abnormal_skin_development0.72437677
112MP0005275_abnormal_skin_tensile0.71626717
113MP0010030_abnormal_orbit_morphology0.71358530
114MP0008569_lethality_at_weaning0.70988638
115MP0000767_abnormal_smooth_muscle0.69868976
116MP0000534_abnormal_ureter_morphology0.69462520
117MP0003755_abnormal_palate_morphology0.68778083
118MP0000372_irregular_coat_pigmentation0.68291447
119MP0000266_abnormal_heart_morphology0.66369184
120MP0000579_abnormal_nail_morphology0.66007023
121MP0005595_abnormal_vascular_smooth0.65549540
122MP0002128_abnormal_blood_circulation0.64953733
123MP0005670_abnormal_white_adipose0.64269557
124MP0002295_abnormal_pulmonary_circulatio0.62722258
125MP0001984_abnormal_olfaction0.62577240
126MP0003045_fibrosis0.59155574
127MP0010386_abnormal_urinary_bladder0.57650390
128MP0001879_abnormal_lymphatic_vessel0.57371341
129MP0005165_increased_susceptibility_to0.57080220
130MP0002114_abnormal_axial_skeleton0.57068068
131MP0002896_abnormal_bone_mineralization0.56769910
132MP0002638_abnormal_pupillary_reflex0.52561192
133MP0000230_abnormal_systemic_arterial0.52466315
134MP0003942_abnormal_urinary_system0.49168941
135MP0006054_spinal_hemorrhage0.46975706
136MP0005332_abnormal_amino_acid0.45155883
137MP0002168_other_aberrant_phenotype0.42707431

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.69960102
2Muscle hypertrophy of the lower extremities (HP:0008968)4.63254581
3Muscle fiber splitting (HP:0003555)4.61978020
4* Muscle fiber inclusion bodies (HP:0100299)4.46615893
5Calf muscle hypertrophy (HP:0008981)4.29954442
6* Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.26954286
7Hyporeflexia of lower limbs (HP:0002600)4.20814544
8Exercise-induced muscle cramps (HP:0003710)4.18087459
9Type 1 muscle fiber predominance (HP:0003803)3.85646140
10* Nemaline bodies (HP:0003798)3.82982068
11Bundle branch block (HP:0011710)3.68258547
12Distal arthrogryposis (HP:0005684)3.62854752
13Abnormality of the calf musculature (HP:0001430)3.61870822
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.52186309
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.52186309
16EMG: myopathic abnormalities (HP:0003458)3.50968276
17Pheochromocytoma (HP:0002666)3.48370153
18Increased serum pyruvate (HP:0003542)3.45381132
19Abnormality of glycolysis (HP:0004366)3.45381132
20Popliteal pterygium (HP:0009756)3.45331241
21Round ear (HP:0100830)3.24820299
22Sudden death (HP:0001699)3.19467672
23Neuroendocrine neoplasm (HP:0100634)3.16777548
24Malignant hyperthermia (HP:0002047)3.10446282
25Difficulty running (HP:0009046)3.09378845
26Type 2 muscle fiber atrophy (HP:0003554)3.08137439
27Acute necrotizing encephalopathy (HP:0006965)2.99188319
28Termporal pattern (HP:0011008)2.99126957
29Insidious onset (HP:0003587)2.99126957
30Asymmetric septal hypertrophy (HP:0001670)2.96683333
31Myotonia (HP:0002486)2.90238197
32Abnormality of the neuromuscular junction (HP:0003398)2.89449685
33Fatigable weakness (HP:0003473)2.89449685
34Distal lower limb muscle weakness (HP:0009053)2.89192416
35Abnormality of the corticospinal tract (HP:0002492)2.83526223
36Weak cry (HP:0001612)2.81976653
37Areflexia of lower limbs (HP:0002522)2.79342329
38Rimmed vacuoles (HP:0003805)2.71573367
39Abnormal mitochondria in muscle tissue (HP:0008316)2.69920077
40Foot dorsiflexor weakness (HP:0009027)2.69092973
41Muscle stiffness (HP:0003552)2.65229597
42Calcaneovalgus deformity (HP:0001848)2.61854250
43Muscle fiber atrophy (HP:0100295)2.60798811
44Frequent falls (HP:0002359)2.59793762
45Abnormality of the foot musculature (HP:0001436)2.58938055
46Progressive macrocephaly (HP:0004481)2.57733034
47Neurofibrillary tangles (HP:0002185)2.56385906
48Myopathic facies (HP:0002058)2.54194838
49Increased variability in muscle fiber diameter (HP:0003557)2.52947152
50Mildly elevated creatine phosphokinase (HP:0008180)2.52094688
51EMG: neuropathic changes (HP:0003445)2.50308869
52Acute encephalopathy (HP:0006846)2.49161151
53Absent phalangeal crease (HP:0006109)2.46849086
54Abnormality of placental membranes (HP:0011409)2.45128651
55Amniotic constriction ring (HP:0009775)2.45128651
56Limb-girdle muscle atrophy (HP:0003797)2.44230780
57Myoglobinuria (HP:0002913)2.43526508
58Aplasia of the musculature (HP:0100854)2.42937258
59Deformed tarsal bones (HP:0008119)2.41552922
60Hip contracture (HP:0003273)2.35435459
61Abnormality of skeletal muscle fiber size (HP:0012084)2.35282797
62Fetal akinesia sequence (HP:0001989)2.34225105
63Generalized muscle weakness (HP:0003324)2.31011571
64Myokymia (HP:0002411)2.29384710
65Steppage gait (HP:0003376)2.28979923
66Sensory axonal neuropathy (HP:0003390)2.28642560
67* Gowers sign (HP:0003391)2.27917971
68Leukodystrophy (HP:0002415)2.25942168
69* Neck muscle weakness (HP:0000467)2.25889798
70Aortic aneurysm (HP:0004942)2.25009259
71Akinesia (HP:0002304)2.22186691
72Scapular winging (HP:0003691)2.20900741
73Heart block (HP:0012722)2.19805988
74Mitochondrial inheritance (HP:0001427)2.18487905
75Slender build (HP:0001533)2.14970811
76Increased connective tissue (HP:0009025)2.14058901
77Abnormal atrioventricular conduction (HP:0005150)2.10819953
78Ankle clonus (HP:0011448)2.10691799
79Atrial fibrillation (HP:0005110)2.09863992
80Limited hip movement (HP:0008800)2.09552352
81Left ventricular hypertrophy (HP:0001712)2.06968433
82Ventricular arrhythmia (HP:0004308)2.05508790
83Proximal amyotrophy (HP:0007126)2.03550766
84Abnormal finger flexion creases (HP:0006143)2.01622799
85Long clavicles (HP:0000890)2.00923306
86Onion bulb formation (HP:0003383)2.00328636
87Lipoatrophy (HP:0100578)1.96144293
88Primary atrial arrhythmia (HP:0001692)1.95884373
89Abnormality of the shoulder girdle musculature (HP:0001435)1.95074776
90Shoulder girdle muscle weakness (HP:0003547)1.92593548
91Difficulty climbing stairs (HP:0003551)1.90841459
92Increased CSF lactate (HP:0002490)1.88947559
93Abnormality of the calcaneus (HP:0008364)1.88137912
94Cerebral hemorrhage (HP:0001342)1.87629183
95Cerebral inclusion bodies (HP:0100314)1.87458884
96Hypoplastic heart (HP:0001961)1.86487687
97Spastic gait (HP:0002064)1.86241268
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.86132189
99Bulbar palsy (HP:0001283)1.85602249
100Parakeratosis (HP:0001036)1.85506595
101Peripheral hypomyelination (HP:0007182)1.83326795
102Spinal rigidity (HP:0003306)1.82935374
103Muscular dystrophy (HP:0003560)1.82699384
104Supraventricular tachycardia (HP:0004755)1.82160880
105Rhabdomyolysis (HP:0003201)1.81846364
106Hepatocellular necrosis (HP:0001404)1.81708969
107Dilated cardiomyopathy (HP:0001644)1.81129950
108Ventricular tachycardia (HP:0004756)1.80493388
109Abnormal auditory evoked potentials (HP:0006958)1.79426029
110Ulnar claw (HP:0001178)1.79229369
111Lower limb muscle weakness (HP:0007340)1.79151799
112Cerebral edema (HP:0002181)1.78915866
113Supraventricular arrhythmia (HP:0005115)1.78234094
114* Respiratory insufficiency due to muscle weakness (HP:0002747)1.78233635
115Abnormality of the hip-girdle musculature (HP:0001445)1.78027868
116Abnormality of the musculature of the pelvis (HP:0001469)1.78027868
117Prolonged QT interval (HP:0001657)1.76209713
118Ulnar deviation of the wrist (HP:0003049)1.75785586
119Limb-girdle muscle weakness (HP:0003325)1.75653530
120Cerebral hypomyelination (HP:0006808)1.75368388
121Hypoplastic left heart (HP:0004383)1.74742047
122Metatarsus adductus (HP:0001840)1.74673967
123Aortic dissection (HP:0002647)1.73747252
124Urinary urgency (HP:0000012)1.73495863
125Alacrima (HP:0000522)1.72914870
126Abnormality of the left ventricular outflow tract (HP:0011103)1.72299516
127Subaortic stenosis (HP:0001682)1.72299516
128Neoplasm of the peripheral nervous system (HP:0100007)1.71464325
129Autoamputation (HP:0001218)1.71227506
130Stridor (HP:0010307)1.70806192
131Hypoplastic ischia (HP:0003175)1.70045465
132Protrusio acetabuli (HP:0003179)1.68988276
133Abnormality of the ischium (HP:0003174)1.67115449
134Aplasia involving bones of the extremities (HP:0009825)1.65664375
135Aplasia involving bones of the upper limbs (HP:0009823)1.65664375
136Aplasia of the phalanges of the hand (HP:0009802)1.65664375
137Palpitations (HP:0001962)1.65472599
138Supranuclear gaze palsy (HP:0000605)1.63519338
139Premature rupture of membranes (HP:0001788)1.63389993
140Pterygium (HP:0001059)1.62899538
141Distal lower limb amyotrophy (HP:0008944)1.62601844
142Waddling gait (HP:0002515)1.62596138
143Wrist flexion contracture (HP:0001239)1.62507204
144* Delayed gross motor development (HP:0002194)1.55883014
145Nonprogressive disorder (HP:0003680)1.55638703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.34560214
2OBSCN4.27227494
3PHKG13.03985774
4PHKG23.03985774
5MARK12.88158391
6OXSR12.70577753
7BCR2.61402573
8TTN2.31308771
9WNK42.19599807
10PKN11.94350367
11NEK11.85897214
12DYRK21.76500334
13FGFR21.75976690
14PDK31.61094797
15PDK41.61094797
16CCNB11.58123832
17NEK91.58010567
18PIK3CA1.54823330
19CASK1.53796267
20MUSK1.52922349
21FRK1.52002206
22CSNK1G31.48702418
23WNK11.47526027
24PAK31.43007960
25PAK61.42421649
26UHMK11.41166759
27MET1.41034007
28NME11.35960605
29MAP3K121.33878758
30ROCK21.32729415
31DMPK1.29146145
32LATS21.26819098
33CSNK1A1L1.24677420
34CSNK1G21.23354053
35EPHB11.22605212
36NTRK11.22197965
37PNCK1.18537388
38MAPK131.18532127
39PDK21.15715293
40PBK1.15060906
41CSNK1G11.11228395
42MINK11.10685948
43PIK3CG1.09717876
44CDK191.08823466
45MYLK1.07415234
46PINK11.04332410
47MAPKAPK31.03318407
48MAP3K41.02111269
49MAPKAPK51.01139320
50SGK4940.99138830
51SGK2230.99138830
52ERBB30.98978445
53ERBB40.98960717
54CDK140.98315699
55EIF2AK30.97677119
56LATS10.93634925
57KSR20.91868467
58ICK0.90001314
59* CAMK2D0.88238260
60TYRO30.87719861
61MAP3K70.87263911
62ILK0.86871202
63ROCK10.85291731
64NTRK20.85219221
65* CAMK2A0.85094491
66MAP2K40.83988561
67EPHB20.83422954
68TRPM70.83001403
69BMPR1B0.80871751
70PLK20.80574068
71ARAF0.80379782
72NEK60.78531259
73PRPF4B0.77101182
74CDK180.76973763
75KSR10.76300242
76* CAMK2G0.75186145
77CDK150.75107528
78PRKAA10.74984467
79LMTK20.73792859
80MAP2K70.72236770
81* CAMK2B0.71802579
82MAP3K90.69714175
83CDK50.69519117
84DDR20.67129091
85TGFBR20.66907745
86PRKAA20.66905181
87PRKCE0.66378837
88AKT30.66135979
89PAK20.65677898
90BRSK20.64812290
91PRKD10.63878847
92CDK11A0.62572232
93PTK20.58149921
94MAP4K20.57489193
95PLK30.57394580
96WEE10.57054276
97AKT20.56612164
98MAPK120.55515358
99* LIMK10.54726172
100STK240.54388846
101FER0.54230948
102TESK10.54169751
103PRKACB0.53833879
104PRKD30.51097511
105CAMK10.50811894
106PDGFRA0.50622560
107PTK2B0.49935612
108GRK70.49222452
109PRKG10.48203087
110BUB10.48182817
111GRK50.48002334
112WNK30.47191725
113TNIK0.47107935
114MAP2K10.46681882
115STK160.46488659
116MOS0.46249536
117CAMK40.45863061
118EIF2AK10.45848996
119NUAK10.44666038
120CDK80.44008040
121IRAK20.42718397
122PRKACA0.41888279
123STK38L0.40849703
124NTRK30.39758282
125MARK20.38018092
126STK380.35947716
127EPHA40.35651088
128BCKDK0.35487268
129RET0.35419921
130BRSK10.34379890
131MELK0.34069394
132DAPK30.32431655
133ADRBK10.32410067
134MAPK70.31777635
135TIE10.31356197
136FGFR10.30725139
137PRKCG0.27436641
138TRIM280.25921104

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.79877560
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.49561858
3Oxidative phosphorylation_Homo sapiens_hsa001903.47351611
4Parkinsons disease_Homo sapiens_hsa050123.16069858
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09134632
6Fatty acid elongation_Homo sapiens_hsa000623.01014429
7Cardiac muscle contraction_Homo sapiens_hsa042602.92401808
8Steroid biosynthesis_Homo sapiens_hsa001002.47084753
9Alzheimers disease_Homo sapiens_hsa050102.45071390
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29760107
11Circadian rhythm_Homo sapiens_hsa047102.05320385
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.03049592
13Butanoate metabolism_Homo sapiens_hsa006502.03048679
14Huntingtons disease_Homo sapiens_hsa050162.00529509
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98913626
16Propanoate metabolism_Homo sapiens_hsa006401.97576554
17Dilated cardiomyopathy_Homo sapiens_hsa054141.96107172
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79704578
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64260263
20* Axon guidance_Homo sapiens_hsa043601.50724884
21Pyruvate metabolism_Homo sapiens_hsa006201.48313365
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47898841
23Ether lipid metabolism_Homo sapiens_hsa005651.46199351
24Sulfur metabolism_Homo sapiens_hsa009201.43512667
25Fatty acid metabolism_Homo sapiens_hsa012121.42797449
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37136461
27Arginine biosynthesis_Homo sapiens_hsa002201.28539244
28Tight junction_Homo sapiens_hsa045301.28228313
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27540749
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26679575
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25513205
32Renal cell carcinoma_Homo sapiens_hsa052111.10174118
33Vitamin B6 metabolism_Homo sapiens_hsa007501.08148019
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06785760
35beta-Alanine metabolism_Homo sapiens_hsa004101.04721362
36Fatty acid degradation_Homo sapiens_hsa000711.01342403
37Serotonergic synapse_Homo sapiens_hsa047261.00912639
38GABAergic synapse_Homo sapiens_hsa047270.98516699
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98146656
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93032746
41Biosynthesis of amino acids_Homo sapiens_hsa012300.92910434
42Arginine and proline metabolism_Homo sapiens_hsa003300.91969365
43Tryptophan metabolism_Homo sapiens_hsa003800.89331817
44Carbon metabolism_Homo sapiens_hsa012000.88871611
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85709693
46Protein export_Homo sapiens_hsa030600.84871166
47Oxytocin signaling pathway_Homo sapiens_hsa049210.81189466
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80712702
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.80685319
50Long-term depression_Homo sapiens_hsa047300.80439646
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79999066
52Vibrio cholerae infection_Homo sapiens_hsa051100.79258597
53Dopaminergic synapse_Homo sapiens_hsa047280.78425786
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77954082
55Phenylalanine metabolism_Homo sapiens_hsa003600.76518012
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76046126
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75448029
58Collecting duct acid secretion_Homo sapiens_hsa049660.73945269
59Starch and sucrose metabolism_Homo sapiens_hsa005000.72669011
60Nitrogen metabolism_Homo sapiens_hsa009100.71524884
61Cholinergic synapse_Homo sapiens_hsa047250.71440258
62Circadian entrainment_Homo sapiens_hsa047130.69630317
63Synaptic vesicle cycle_Homo sapiens_hsa047210.69279667
64Linoleic acid metabolism_Homo sapiens_hsa005910.68931945
65Hedgehog signaling pathway_Homo sapiens_hsa043400.68323252
66Glutamatergic synapse_Homo sapiens_hsa047240.68197159
67Gap junction_Homo sapiens_hsa045400.65589229
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.62556130
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62451281
70PPAR signaling pathway_Homo sapiens_hsa033200.61323315
71Folate biosynthesis_Homo sapiens_hsa007900.60858018
72Ovarian steroidogenesis_Homo sapiens_hsa049130.60372321
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59909894
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59389117
75ECM-receptor interaction_Homo sapiens_hsa045120.59000644
76Pentose phosphate pathway_Homo sapiens_hsa000300.58960911
77Adherens junction_Homo sapiens_hsa045200.58477495
78ErbB signaling pathway_Homo sapiens_hsa040120.58190862
79Focal adhesion_Homo sapiens_hsa045100.56570078
80Hippo signaling pathway_Homo sapiens_hsa043900.56412414
81Peroxisome_Homo sapiens_hsa041460.54059506
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53890571
83Tyrosine metabolism_Homo sapiens_hsa003500.53662073
84Selenocompound metabolism_Homo sapiens_hsa004500.53239911
85Complement and coagulation cascades_Homo sapiens_hsa046100.52648676
86Sphingolipid metabolism_Homo sapiens_hsa006000.52193722
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51513515
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51196672
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51100730
90Insulin resistance_Homo sapiens_hsa049310.51074005
91TGF-beta signaling pathway_Homo sapiens_hsa043500.50937455
92Salivary secretion_Homo sapiens_hsa049700.50231291
93Lysine degradation_Homo sapiens_hsa003100.49764983
94Calcium signaling pathway_Homo sapiens_hsa040200.49035967
95Gastric acid secretion_Homo sapiens_hsa049710.49016644
96Morphine addiction_Homo sapiens_hsa050320.48965870
97Nicotine addiction_Homo sapiens_hsa050330.48539762
98Bile secretion_Homo sapiens_hsa049760.48177661
99Ras signaling pathway_Homo sapiens_hsa040140.46108860
100Renin secretion_Homo sapiens_hsa049240.45353756
101Cocaine addiction_Homo sapiens_hsa050300.45324719
102Melanogenesis_Homo sapiens_hsa049160.44923702
103Dorso-ventral axis formation_Homo sapiens_hsa043200.44396265
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44179546
105Metabolic pathways_Homo sapiens_hsa011000.43891571
106AMPK signaling pathway_Homo sapiens_hsa041520.43744915
107cAMP signaling pathway_Homo sapiens_hsa040240.42307983
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42084469
109Regulation of autophagy_Homo sapiens_hsa041400.41187523
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40733290
111GnRH signaling pathway_Homo sapiens_hsa049120.40732324
112Fatty acid biosynthesis_Homo sapiens_hsa000610.40045350
113Phototransduction_Homo sapiens_hsa047440.40041767
114Insulin signaling pathway_Homo sapiens_hsa049100.39396820
115Endocytosis_Homo sapiens_hsa041440.38296503
116Proteoglycans in cancer_Homo sapiens_hsa052050.37975777
117Glutathione metabolism_Homo sapiens_hsa004800.37026632
118Taste transduction_Homo sapiens_hsa047420.36003426
119Proteasome_Homo sapiens_hsa030500.34924425
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34895583
121Oocyte meiosis_Homo sapiens_hsa041140.34681755
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.34120702
123Fructose and mannose metabolism_Homo sapiens_hsa000510.33972010
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33677050
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33644356
126Glucagon signaling pathway_Homo sapiens_hsa049220.33385271
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33351333
128* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32894656
129Histidine metabolism_Homo sapiens_hsa003400.32727812
130Amphetamine addiction_Homo sapiens_hsa050310.32629457
131Insulin secretion_Homo sapiens_hsa049110.32393626
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31768740
133Viral myocarditis_Homo sapiens_hsa054160.31121857
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30568437
135Purine metabolism_Homo sapiens_hsa002300.30088012

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