CFLAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.08492220
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08492220
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08492220
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.08492220
5modulation by symbiont of host immune response (GO:0052553)5.08492220
6positive regulation by symbiont of host defense response (GO:0052509)5.08492220
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00058964
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75234168
9negative regulation of cell killing (GO:0031342)4.75234168
10response to peptidoglycan (GO:0032494)4.47662413
11regulation of B cell receptor signaling pathway (GO:0050855)4.45795855
12NIK/NF-kappaB signaling (GO:0038061)4.27486204
13neutrophil activation involved in immune response (GO:0002283)4.27196060
14positive regulation of interferon-alpha production (GO:0032727)4.19811124
15positive regulation of gamma-delta T cell activation (GO:0046645)4.06180975
16response to muramyl dipeptide (GO:0032495)4.04978760
17regulation of interferon-alpha production (GO:0032647)4.01508391
18regulation of gamma-delta T cell differentiation (GO:0045586)3.91370646
19macrophage activation involved in immune response (GO:0002281)3.82462018
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.75782414
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75223604
22regulation of interferon-beta biosynthetic process (GO:0045357)3.70469565
23cellular extravasation (GO:0045123)3.67651768
24positive regulation of heat generation (GO:0031652)3.62983928
25detection of other organism (GO:0098543)3.61999921
26positive regulation of chemokine biosynthetic process (GO:0045080)3.56418895
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.56296847
28detection of external biotic stimulus (GO:0098581)3.53475118
29natural killer cell mediated cytotoxicity (GO:0042267)3.52507079
30natural killer cell mediated immunity (GO:0002228)3.52507079
31response to type I interferon (GO:0034340)3.51660749
32cellular response to type I interferon (GO:0071357)3.49753093
33type I interferon signaling pathway (GO:0060337)3.49753093
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49382927
35response to host immune response (GO:0052572)3.49382927
36negative regulation of T cell mediated immunity (GO:0002710)3.45770902
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.45579841
38positive regulation of interleukin-12 production (GO:0032735)3.39489547
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37751316
40negative regulation of lipid storage (GO:0010888)3.36610201
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.36331008
42T-helper 1 type immune response (GO:0042088)3.33795560
43regulation of fever generation (GO:0031620)3.31125583
44granulocyte activation (GO:0036230)3.30878633
45B cell receptor signaling pathway (GO:0050853)3.29866606
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29489845
47response to interleukin-15 (GO:0070672)3.25699910
48detection of bacterium (GO:0016045)3.25648286
49positive regulation of interferon-beta production (GO:0032728)3.25082879
50cellular response to ethanol (GO:0071361)3.25054716
51negative thymic T cell selection (GO:0045060)3.24806599
52positive regulation of cellular amide metabolic process (GO:0034250)3.22852489
53negative T cell selection (GO:0043383)3.22549974
54neutrophil activation (GO:0042119)3.20526442
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19910675
56hydrogen peroxide biosynthetic process (GO:0050665)3.19746468
57detection of molecule of bacterial origin (GO:0032490)3.17676361
58I-kappaB phosphorylation (GO:0007252)3.16938811
59positive regulation of natural killer cell differentiation (GO:0032825)3.15553427
60antigen processing and presentation of endogenous antigen (GO:0019883)3.15329585
61cellular response to virus (GO:0098586)3.15292281
62response to host (GO:0075136)3.14523600
63response to host defenses (GO:0052200)3.14523600
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14523600
65positive regulation of humoral immune response (GO:0002922)3.13729938
66positive regulation of antigen processing and presentation (GO:0002579)3.13373642
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13351462
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13351462
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11302693
70immunoglobulin mediated immune response (GO:0016064)3.09517905
71detection of biotic stimulus (GO:0009595)3.08456018
72microglial cell activation (GO:0001774)3.06475844
73myeloid dendritic cell differentiation (GO:0043011)3.05686433
74cellular response to interleukin-15 (GO:0071350)3.05366142
75regulation of RIG-I signaling pathway (GO:0039535)3.03192353
76respiratory burst (GO:0045730)3.02637286
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02539957
78regulation of chemokine biosynthetic process (GO:0045073)3.02334752
79cytokine secretion (GO:0050663)3.00717754
80regulation of T-helper 1 cell differentiation (GO:0045625)2.99595819
81defense response to protozoan (GO:0042832)2.98349885
82superoxide anion generation (GO:0042554)2.98198725
83germinal center formation (GO:0002467)2.96354351
84interferon-gamma-mediated signaling pathway (GO:0060333)2.94820918
85myeloid cell activation involved in immune response (GO:0002275)2.91580635
86negative regulation of leukocyte mediated immunity (GO:0002704)2.89892217
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89559512
88cellular response to interferon-beta (GO:0035458)2.89251826
89modulation by symbiont of host cellular process (GO:0044068)2.88530537
90myeloid dendritic cell activation (GO:0001773)2.88352252
91positive thymic T cell selection (GO:0045059)2.87592220
92regulation of interleukin-12 production (GO:0032655)2.87071394
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85943070
94positive T cell selection (GO:0043368)2.85113557
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84249618
96regulation of activation of Janus kinase activity (GO:0010533)2.83651636
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83396288
98response to protozoan (GO:0001562)2.83376157
99regulation of antigen processing and presentation (GO:0002577)2.80263361
100cell adhesion mediated by integrin (GO:0033627)2.80194535
101negative regulation of interleukin-12 production (GO:0032695)2.79973856
102negative regulation of interleukin-17 production (GO:0032700)2.79837345
103regulation of gamma-delta T cell activation (GO:0046643)2.79404830
104reactive oxygen species biosynthetic process (GO:1903409)2.79282598
105activated T cell proliferation (GO:0050798)2.78790761
106regulation of alpha-beta T cell proliferation (GO:0046640)2.77813207
107macrophage activation (GO:0042116)2.76555139
108negative regulation of viral genome replication (GO:0045071)2.76526062
109regulation of mononuclear cell migration (GO:0071675)2.76273861
110positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75762320
111response to interferon-alpha (GO:0035455)2.75353849
112negative regulation of T-helper cell differentiation (GO:0045623)2.74652745
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.74652745
114regulation of MHC class I biosynthetic process (GO:0045343)2.74320307
115production of molecular mediator involved in inflammatory response (GO:0002532)2.74003335
116leukocyte aggregation (GO:0070486)2.73634606
117monocyte chemotaxis (GO:0002548)2.72440981
118negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72009335
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71935266
120interferon-gamma production (GO:0032609)2.71612882
121regulation of immunoglobulin secretion (GO:0051023)2.71256735
122positive regulation of interleukin-17 production (GO:0032740)2.71143421
123tolerance induction (GO:0002507)2.70333496
124regulation of interleukin-1 beta secretion (GO:0050706)2.70177275
125regulation of heat generation (GO:0031650)2.69961132
126positive regulation of interleukin-1 beta secretion (GO:0050718)2.68732265
127positive regulation of cytokine biosynthetic process (GO:0042108)2.68554664
128negative regulation of adaptive immune response (GO:0002820)2.68482266
129regulation of tolerance induction (GO:0002643)2.68319752
130T cell migration (GO:0072678)2.68143313
131JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.67739577
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66005663
133regulation of interleukin-17 production (GO:0032660)2.65094336
134neutrophil mediated immunity (GO:0002446)2.65028383
135regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.64801889
136T cell selection (GO:0045058)2.61811939
137myeloid leukocyte mediated immunity (GO:0002444)2.61486048
138regulation of regulatory T cell differentiation (GO:0045589)2.58875590
139positive regulation of tolerance induction (GO:0002645)2.58533806
140cellular response to exogenous dsRNA (GO:0071360)2.56404646
141negative regulation of interleukin-6 production (GO:0032715)2.54944489
142dendritic cell migration (GO:0036336)2.53708610
143regulation of interleukin-6 biosynthetic process (GO:0045408)2.53688636
144negative regulation of B cell mediated immunity (GO:0002713)2.49545220
145negative regulation of immunoglobulin mediated immune response (GO:0002890)2.49545220
146regulation of T cell tolerance induction (GO:0002664)2.49434895
147regulation of T cell mediated cytotoxicity (GO:0001914)2.47660754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.47306423
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.51755275
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.33402752
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.53145273
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19208573
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.79055089
7* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73036458
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69815989
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.55896204
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36193477
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.23020449
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20864847
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90753566
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66655933
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55328305
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27563602
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18579846
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.18444462
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17704352
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.10003865
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.98526272
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97165899
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88027717
24RUNX_20019798_ChIP-Seq_JUKART_Human1.85402477
25VDR_24787735_ChIP-Seq_THP-1_Human1.76660494
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75253030
27* GATA2_21666600_ChIP-Seq_HMVEC_Human1.72805345
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70796921
29* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69421697
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68701134
31GATA1_22025678_ChIP-Seq_K562_Human1.68259045
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66258899
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.65545784
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63203058
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.62008647
36* PU_27001747_Chip-Seq_BMDM_Mouse1.61181006
37SCL_19346495_ChIP-Seq_HPC-7_Human1.58281450
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53658569
39SPI1_23547873_ChIP-Seq_NB4_Human1.51679647
40* MYB_26560356_Chip-Seq_TH2_Human1.50044520
41* SMAD_19615063_ChIP-ChIP_OVARY_Human1.48824965
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40617922
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36677317
44TP53_16413492_ChIP-PET_HCT116_Human1.35201880
45DROSHA_22980978_ChIP-Seq_HELA_Human1.34508154
46* MYB_26560356_Chip-Seq_TH1_Human1.34392570
47* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32484625
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31873978
49SPI1_23127762_ChIP-Seq_K562_Human1.31830918
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30715037
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29297912
52* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28464318
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28247293
54GATA1_19941826_ChIP-Seq_K562_Human1.28052369
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26662043
56* VDR_24763502_ChIP-Seq_THP-1_Human1.26100057
57* MAF_26560356_Chip-Seq_TH1_Human1.22706749
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22421457
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.21655327
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18660981
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17358454
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16448787
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.15601288
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14139556
65GATA3_27048872_Chip-Seq_THYMUS_Human1.09493933
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08380682
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06926969
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05030743
69* GATA3_26560356_Chip-Seq_TH2_Human1.04871809
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04871595
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04736922
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.04212709
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04203791
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04181922
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04181922
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03941821
77AHR_22903824_ChIP-Seq_MCF-7_Human1.03678479
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03580389
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03457106
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01980650
81VDR_21846776_ChIP-Seq_THP-1_Human1.01827076
82SMRT_27268052_Chip-Seq_Bcells_Human1.01257497
83* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00787850
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00787850
85* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00640981
86CJUN_26792858_Chip-Seq_BT549_Human1.00500434
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00101160
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99928539
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99003412
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98286050
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96364711
92* SOX2_20726797_ChIP-Seq_SW620_Human0.96338079
93AR_21572438_ChIP-Seq_LNCaP_Human0.95455954
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92523990
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92435161
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91431690
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.91311837
98* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90183881
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.90138006
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88403368
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87082215
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86734548
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86629893
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.86443427
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86076383
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85530359
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85516720
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85182763
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84726657
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84217719
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83829038
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.83393403
113ER_23166858_ChIP-Seq_MCF-7_Human0.82100501
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81010416
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80869526
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80869526
117RXR_22108803_ChIP-Seq_LS180_Human0.80818590
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80591679
119STAT3_23295773_ChIP-Seq_U87_Human0.80553449
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79805610
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79803021
122* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79386900
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78947467
124* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78540698
125* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78362367
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78001334
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77289264
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76566958
129TP63_23658742_ChIP-Seq_EP156T_Human0.76438442
130* UTX_26944678_Chip-Seq_JUKART_Human0.75111005
131MAF_26560356_Chip-Seq_TH2_Human0.74704182
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.73348396
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.73034081
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71799090
135TCF7_22412390_ChIP-Seq_EML_Mouse0.71519771
136* GATA2_19941826_ChIP-Seq_K562_Human0.71127613
137EGR1_19032775_ChIP-ChIP_M12_Human0.70354102
138* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69816084
139PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.69736237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03150486
2MP0009785_altered_susceptibility_to3.51625541
3MP0003436_decreased_susceptibility_to3.39049995
4MP0003724_increased_susceptibility_to2.96905070
5MP0002148_abnormal_hypersensitivity_rea2.91881025
6MP0002419_abnormal_innate_immunity2.80526458
7MP0005000_abnormal_immune_tolerance2.78637502
8MP0000685_abnormal_immune_system2.71672479
9MP0006082_CNS_inflammation2.70354196
10MP0005025_abnormal_response_to2.69549998
11MP0001790_abnormal_immune_system2.68753047
12MP0005387_immune_system_phenotype2.68753047
13MP0003303_peritoneal_inflammation2.67317404
14MP0005671_abnormal_response_to2.46975243
15MP0001800_abnormal_humoral_immune2.39447755
16MP0002452_abnormal_antigen_presenting2.37886148
17MP0004510_myositis2.35160797
18MP0000569_abnormal_digit_pigmentation2.33208172
19MP0002723_abnormal_immune_serum2.29820790
20MP0002254_reproductive_system_inflammat2.20795042
21MP0002138_abnormal_hepatobiliary_system2.17549284
22MP0004947_skin_inflammation2.07423319
23MP0005058_abnormal_lysosome_morphology1.99580643
24MP0001819_abnormal_immune_cell1.99496820
25MP0009764_decreased_sensitivity_to1.98320430
26MP0002006_tumorigenesis1.96638106
27MP0002420_abnormal_adaptive_immunity1.95474179
28MP0001853_heart_inflammation1.91714331
29MP0005464_abnormal_platelet_physiology1.91365618
30MP0005451_abnormal_body_composition1.86190353
31MP0001533_abnormal_skeleton_physiology1.82583473
32MP0003646_muscle_fatigue1.81445694
33MP0002166_altered_tumor_susceptibility1.80041234
34MP0001845_abnormal_inflammatory_respons1.76031224
35MP0010155_abnormal_intestine_physiology1.73592863
36MP0003300_gastrointestinal_ulcer1.72117170
37MP0009278_abnormal_bone_marrow1.71285267
38MP0002405_respiratory_system_inflammati1.70083355
39MP0003191_abnormal_cellular_cholesterol1.69029751
40MP0004130_abnormal_muscle_cell1.68495934
41MP0008469_abnormal_protein_level1.65661057
42MP0003448_altered_tumor_morphology1.62245334
43MP0004883_abnormal_blood_vessel1.47990225
44MP0003866_abnormal_defecation1.45010715
45MP0003172_abnormal_lysosome_physiology1.42475161
46* MP0000716_abnormal_immune_system1.40869560
47MP0002998_abnormal_bone_remodeling1.39540363
48MP0005397_hematopoietic_system_phenotyp1.38970101
49MP0001545_abnormal_hematopoietic_system1.38970101
50MP0005360_urolithiasis1.30940851
51MP0002398_abnormal_bone_marrow1.30629549
52MP0005310_abnormal_salivary_gland1.27343817
53MP0009840_abnormal_foam_cell1.26802405
54MP0003828_pulmonary_edema1.23478206
55MP0000343_altered_response_to1.20798520
56MP0000858_altered_metastatic_potential1.20058378
57MP0009763_increased_sensitivity_to1.19769104
58MP0008057_abnormal_DNA_replication1.18944752
59MP0002277_abnormal_respiratory_mucosa1.18778159
60MP0003656_abnormal_erythrocyte_physiolo1.18680048
61MP0003690_abnormal_glial_cell1.18472395
62MP0009333_abnormal_splenocyte_physiolog1.14924508
63MP0005167_abnormal_blood-brain_barrier1.14285245
64MP0003453_abnormal_keratinocyte_physiol1.11200012
65MP0003075_altered_response_to1.10935937
66MP0000689_abnormal_spleen_morphology1.10863794
67MP0003763_abnormal_thymus_physiology1.10157272
68MP0003252_abnormal_bile_duct1.09559311
69MP0002139_abnormal_hepatobiliary_system1.08954380
70MP0008004_abnormal_stomach_pH1.08561643
71* MP0002429_abnormal_blood_cell1.08514216
72MP0005174_abnormal_tail_pigmentation1.08447206
73MP0003195_calcinosis1.07603327
74MP0000703_abnormal_thymus_morphology1.06153604
75MP0001873_stomach_inflammation1.05549845
76MP0004782_abnormal_surfactant_physiolog1.04750695
77MP0000371_diluted_coat_color1.02478335
78MP0000465_gastrointestinal_hemorrhage1.00984237
79MP0002722_abnormal_immune_system1.00897400
80MP0000604_amyloidosis0.98798116
81MP0003091_abnormal_cell_migration0.98707904
82MP0002396_abnormal_hematopoietic_system0.97407992
83MP0001663_abnormal_digestive_system0.96612689
84MP0005164_abnormal_response_to0.96567611
85MP0004484_altered_response_of0.95110640
86MP0003183_abnormal_peptide_metabolism0.94680200
87MP0002933_joint_inflammation0.94616028
88MP0003566_abnormal_cell_adhesion0.92508315
89MP0005390_skeleton_phenotype0.91765000
90MP0005166_decreased_susceptibility_to0.89363572
91MP0002132_abnormal_respiratory_system0.88567861
92MP0003045_fibrosis0.87608107
93MP0010352_gastrointestinal_tract_polyps0.87348051
94MP0000609_abnormal_liver_physiology0.86774586
95MP0004043_abnormal_pH_regulation0.86567701
96MP0008961_abnormal_basal_metabolism0.86536622
97MP0000249_abnormal_blood_vessel0.86415786
98MP0009115_abnormal_fat_cell0.84801270
99MP0001958_emphysema0.83489458
100MP0008438_abnormal_cutaneous_collagen0.81958102
101MP0000015_abnormal_ear_pigmentation0.80916789
102MP0002136_abnormal_kidney_physiology0.80560964
103MP0000767_abnormal_smooth_muscle0.79981884
104MP0005076_abnormal_cell_differentiation0.79807729
105MP0010307_abnormal_tumor_latency0.79596415
106MP0003186_abnormal_redox_activity0.79036304
107MP0006054_spinal_hemorrhage0.77248208
108MP0001851_eye_inflammation0.75832127
109MP0001501_abnormal_sleep_pattern0.74820020
110MP0005266_abnormal_metabolism0.74494987
111MP0004381_abnormal_hair_follicle0.72534421
112MP0008260_abnormal_autophagy0.71860794
113MP0005023_abnormal_wound_healing0.70799450
114MP0001879_abnormal_lymphatic_vessel0.70772280
115MP0005257_abnormal_intraocular_pressure0.69828824
116MP0002332_abnormal_exercise_endurance0.69470391
117MP0004808_abnormal_hematopoietic_stem0.69139425
118MP0009765_abnormal_xenobiotic_induced0.68458460
119MP0002928_abnormal_bile_duct0.67754292
120MP0005365_abnormal_bile_salt0.67659324
121MP0005376_homeostasis/metabolism_phenot0.67535394
122MP0002168_other_aberrant_phenotype0.65641142
123MP0005408_hypopigmentation0.65366552
124MP0003221_abnormal_cardiomyocyte_apopto0.62981407

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.08246200
2Recurrent abscess formation (HP:0002722)6.03382217
3Recurrent bacterial skin infections (HP:0005406)5.83131517
4Recurrent gram-negative bacterial infections (HP:0005420)5.06212989
5Elevated erythrocyte sedimentation rate (HP:0003565)4.63423586
6Stomatitis (HP:0010280)4.58691313
7Mediastinal lymphadenopathy (HP:0100721)4.40581758
8Abnormality of macrophages (HP:0004311)4.33615078
9Autoimmune thrombocytopenia (HP:0001973)3.96170420
10Recurrent skin infections (HP:0001581)3.95100227
11Recurrent fungal infections (HP:0002841)3.91077448
12Gingivitis (HP:0000230)3.88549678
13Orchitis (HP:0100796)3.85810510
14Retrobulbar optic neuritis (HP:0100654)3.85636998
15Optic neuritis (HP:0100653)3.85636998
16Myositis (HP:0100614)3.71737319
17Vasculitis (HP:0002633)3.60064072
18Prostate neoplasm (HP:0100787)3.58893842
19Myocardial infarction (HP:0001658)3.50046238
20Recurrent viral infections (HP:0004429)3.49391249
21Thick nail (HP:0001805)3.39790431
22Periodontitis (HP:0000704)3.35493225
23Systemic lupus erythematosus (HP:0002725)3.27463400
24Genetic anticipation (HP:0003743)3.22615159
25Vacuolated lymphocytes (HP:0001922)3.19880547
26Recurrent cutaneous fungal infections (HP:0011370)3.19721556
27Chronic mucocutaneous candidiasis (HP:0002728)3.19721556
28Increased IgM level (HP:0003496)3.17949265
29Pulmonary infiltrates (HP:0002113)3.10657587
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07723866
31Tetraparesis (HP:0002273)2.98577488
32Recurrent bronchitis (HP:0002837)2.97302632
33Pustule (HP:0200039)2.96699271
34Gingival bleeding (HP:0000225)2.94246698
35Gastrointestinal infarctions (HP:0005244)2.92774958
36Abnormality of the fingertips (HP:0001211)2.88582244
37Hematochezia (HP:0002573)2.88457721
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85058896
39Abnormality of T cells (HP:0002843)2.80768449
40Leukocytosis (HP:0001974)2.76943755
41Joint hemorrhage (HP:0005261)2.75646468
42Obstructive lung disease (HP:0006536)2.70894467
43Chronic obstructive pulmonary disease (HP:0006510)2.70894467
44Arterial thrombosis (HP:0004420)2.69909020
45Basal ganglia calcification (HP:0002135)2.66336908
46Increased IgE level (HP:0003212)2.59836571
47Chest pain (HP:0100749)2.59684740
48Interstitial pulmonary disease (HP:0006530)2.51858853
49Premature loss of primary teeth (HP:0006323)2.47758477
50Amyloidosis (HP:0011034)2.47084879
51Hemoptysis (HP:0002105)2.45881887
52Osteomyelitis (HP:0002754)2.45471601
53Eosinophilia (HP:0001880)2.42583061
54Keratoconjunctivitis sicca (HP:0001097)2.40986665
55Glomerulonephritis (HP:0000099)2.40242991
56Osteolytic defects of the hand bones (HP:0009699)2.39588235
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.39588235
58Prolonged bleeding time (HP:0003010)2.38673180
59Urticaria (HP:0001025)2.38529553
60Meningitis (HP:0001287)2.37806927
61Keratoconjunctivitis (HP:0001096)2.37114464
62Pulmonary embolism (HP:0002204)2.37079958
63Esophageal varix (HP:0002040)2.37009032
64Axonal loss (HP:0003447)2.35584970
65Colitis (HP:0002583)2.29694000
66Gastrointestinal inflammation (HP:0004386)2.28747035
67Cellulitis (HP:0100658)2.27826180
68Recurrent pneumonia (HP:0006532)2.26099525
69Clumsiness (HP:0002312)2.25819663
70Abnormality of the prostate (HP:0008775)2.24738461
71Increased cerebral lipofuscin (HP:0011813)2.23537959
72Abnormality of the endocardium (HP:0004306)2.22366848
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.21249079
74Abnormality of T cell number (HP:0011839)2.20529513
75Nephritis (HP:0000123)2.19736935
76Hypergammaglobulinemia (HP:0010702)2.19333496
77Stomach cancer (HP:0012126)2.18663896
78Abnormality of T cell physiology (HP:0011840)2.17416394
79Joint swelling (HP:0001386)2.15801522
80Abnormality of the pleura (HP:0002103)2.14657545
81Hydroxyprolinuria (HP:0003080)2.13240082
82Abnormality of proline metabolism (HP:0010907)2.13240082
83Peritonitis (HP:0002586)2.13032187
84Bone pain (HP:0002653)2.09694338
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.09313764
86Chronic diarrhea (HP:0002028)2.08659269
87Chronic otitis media (HP:0000389)2.08450711
88Hypochromic anemia (HP:0001931)2.06491845
89Granulocytopenia (HP:0001913)2.05179276
90Spontaneous hematomas (HP:0007420)2.04448770
91Panhypogammaglobulinemia (HP:0003139)2.03481809
92Epistaxis (HP:0000421)2.02870549
93Recurrent lower respiratory tract infections (HP:0002783)2.00535690
94Vertigo (HP:0002321)1.99468915
95T lymphocytopenia (HP:0005403)1.99442503
96Anorexia (HP:0002039)1.96515356
97Neoplasm of the tracheobronchial system (HP:0100552)1.95677947
98Nasal polyposis (HP:0100582)1.94579056
99Hemorrhage of the eye (HP:0011885)1.93523867
100Hyperventilation (HP:0002883)1.93442531
101Inflammation of the large intestine (HP:0002037)1.92387748
102Nausea (HP:0002018)1.88785933
103Progressive cerebellar ataxia (HP:0002073)1.88347967
104Pulmonary artery stenosis (HP:0004415)1.87916681
105Abnormality of eosinophils (HP:0001879)1.87822899
106Abnormality of the pericardium (HP:0001697)1.86893302
107Protruding tongue (HP:0010808)1.86455123
108Autoimmune hemolytic anemia (HP:0001890)1.85722059
109Hemiplegia (HP:0002301)1.85476332
110Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84398443
111Abnormality of the peritoneum (HP:0002585)1.84263695
112Cheilitis (HP:0100825)1.83888487
113Gangrene (HP:0100758)1.83555757
114Alveolar cell carcinoma (HP:0006519)1.83318212
115Postural instability (HP:0002172)1.83178229
116Complement deficiency (HP:0004431)1.83132014
117Abnormality of the nasal mucosa (HP:0000433)1.82947392
118Skin ulcer (HP:0200042)1.82323885
119Abnormality of the common coagulation pathway (HP:0010990)1.82228287
120Lymphopenia (HP:0001888)1.82060138
121Gastrointestinal stroma tumor (HP:0100723)1.81623118
122Menorrhagia (HP:0000132)1.80725696
123Dysmetric saccades (HP:0000641)1.79825166
124Vertebral compression fractures (HP:0002953)1.79743984
125Arthralgia (HP:0002829)1.79643187
126Pathologic fracture (HP:0002756)1.79426558
127Encephalitis (HP:0002383)1.79327878
128Episodic fever (HP:0001954)1.79069658
129IgA deficiency (HP:0002720)1.78516710
130Slow saccadic eye movements (HP:0000514)1.78502813
131Agammaglobulinemia (HP:0004432)1.77864897
132Viral hepatitis (HP:0006562)1.77861545
133Recurrent sinusitis (HP:0011108)1.76904283
134Porencephaly (HP:0002132)1.76777631
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.75515103
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75353902
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75353902
138Subacute progressive viral hepatitis (HP:0006572)1.74965702
139Keratitis (HP:0000491)1.73689086
140Facial diplegia (HP:0001349)1.71995549
141Bronchitis (HP:0012387)1.71501846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.17386589
2IRAK33.53620324
3TYK23.34415751
4TBK13.31268890
5IKBKE3.20116799
6IRAK43.02463724
7JAK32.95060758
8IKBKB2.67526702
9TXK2.59231919
10ACVR1B2.48071300
11RIPK42.43530473
12JAK12.39214232
13MAP3K132.23647883
14MAP4K12.12640631
15TAOK32.07643734
16CHUK2.04776752
17KIT1.84700819
18BLK1.79158069
19PBK1.69082299
20FGFR41.66835344
21TGFBR21.65741510
22ERN11.56344880
23ZAP701.43985225
24CSK1.41611907
25EPHA31.40972439
26EPHB11.40955174
27NEK91.40144842
28GRK61.30644087
29FGFR31.29003040
30EIF2AK21.26705188
31TNK21.25822933
32CDC42BPA1.24857914
33MAP3K71.16792949
34TEC1.16610013
35MST1R1.16515035
36HCK1.14024629
37PTK2B1.12901357
38JAK21.12878530
39RPS6KA41.11226902
40PRPF4B1.10950393
41INSRR1.09730457
42SGK21.08824314
43LCK1.07950047
44IRAK11.07140688
45MARK21.07077290
46CSF1R1.04264311
47PIM21.02730019
48SYK1.01691944
49NUAK11.01563905
50WNK11.00798661
51NLK1.00536509
52MAP3K21.00347347
53PIM10.98157368
54AKT30.94957299
55BTK0.94730995
56TRPM70.93336382
57CDK120.91746251
58LYN0.90898418
59MAP3K10.90054987
60MELK0.87051363
61MARK30.86259025
62TAOK10.86099876
63CAMKK20.85601758
64STK30.85407587
65ITK0.85146415
66STK100.84508236
67SGK30.83957491
68TRIB30.83643720
69DAPK20.83122566
70PTK60.81237642
71STK40.80786936
72CAMK1D0.80255267
73MST40.77962529
74BMPR20.77944235
75PDK10.76185464
76MAP3K60.75817996
77GRK70.75799121
78SIK10.73688848
79RIPK10.72162834
80TTN0.71417478
81BMX0.70784032
82ABL10.66913364
83MAPK70.66799417
84MAPK120.66538249
85FGR0.65736524
86FLT30.65709974
87MAP3K110.64984010
88KSR20.64368186
89STK380.63683839
90IRAK20.63651215
91MAP3K100.63535959
92ADRBK10.62302754
93STK110.61649427
94MAP2K60.60909765
95ERBB40.57717539
96PRKAA20.57236885
97EGFR0.56693822
98ABL20.56081044
99MAP2K30.55672676
100PRKCQ0.55411624
101PDPK10.55341795
102SGK4940.55137478
103SGK2230.55137478
104RPS6KA60.54191341
105PDGFRB0.53256869
106MAP3K30.53144152
107LATS10.53028420
108FRK0.52525692
109MAP3K50.52332032
110PIK3CG0.51532199
111CAMKK10.51270604
112YES10.49937049
113PRKCD0.49233690
114RET0.48505029
115CAMK40.48176689
116CDK60.46837146
117PKN10.45632873
118MATK0.44605035
119IGF1R0.43021597
120SIK20.42120798
121NME20.41896933
122ZAK0.40454119
123PIK3CA0.39986261
124GSK3A0.39296791
125MAPKAPK20.38097201
126CAMK1G0.35626474
127INSR0.34170732
128SIK30.32340152
129ADRBK20.31328669
130FES0.29840290
131MOS0.29708077
132HIPK20.28702380
133MAPK110.27500935
134KDR0.27432831
135TIE10.23704293
136BMPR1B0.23139755

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.22870242
2Leishmaniasis_Homo sapiens_hsa051403.08506833
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.99783937
4Allograft rejection_Homo sapiens_hsa053302.81189768
5Staphylococcus aureus infection_Homo sapiens_hsa051502.79528732
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.75598919
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.64350569
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.46306192
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31235662
10Measles_Homo sapiens_hsa051622.30921716
11Malaria_Homo sapiens_hsa051442.26703253
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25461862
13Osteoclast differentiation_Homo sapiens_hsa043802.22884715
14Legionellosis_Homo sapiens_hsa051342.21250528
15Pertussis_Homo sapiens_hsa051332.11535955
16* TNF signaling pathway_Homo sapiens_hsa046682.00961365
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.00232693
18Influenza A_Homo sapiens_hsa051641.87353606
19Rheumatoid arthritis_Homo sapiens_hsa053231.86105091
20Tuberculosis_Homo sapiens_hsa051521.79782980
21Asthma_Homo sapiens_hsa053101.72800202
22Type I diabetes mellitus_Homo sapiens_hsa049401.71688046
23Toxoplasmosis_Homo sapiens_hsa051451.67140349
24African trypanosomiasis_Homo sapiens_hsa051431.66039598
25Hematopoietic cell lineage_Homo sapiens_hsa046401.63003567
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51814153
27Herpes simplex infection_Homo sapiens_hsa051681.51519151
28Caffeine metabolism_Homo sapiens_hsa002321.43387555
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.42473990
30Autoimmune thyroid disease_Homo sapiens_hsa053201.39023918
31B cell receptor signaling pathway_Homo sapiens_hsa046621.36294053
32Primary immunodeficiency_Homo sapiens_hsa053401.34860266
33Complement and coagulation cascades_Homo sapiens_hsa046101.30787302
34* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26077383
35Dorso-ventral axis formation_Homo sapiens_hsa043201.23056614
36* Apoptosis_Homo sapiens_hsa042101.22716063
37Hepatitis C_Homo sapiens_hsa051601.22450549
38Salmonella infection_Homo sapiens_hsa051321.17638204
39Chemokine signaling pathway_Homo sapiens_hsa040621.14121845
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08543310
41Lysosome_Homo sapiens_hsa041421.08053166
42Antigen processing and presentation_Homo sapiens_hsa046121.07779297
43Phagosome_Homo sapiens_hsa041451.04899517
44Hepatitis B_Homo sapiens_hsa051611.04456941
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01674982
46T cell receptor signaling pathway_Homo sapiens_hsa046600.98206903
47Viral myocarditis_Homo sapiens_hsa054160.97847840
48Amoebiasis_Homo sapiens_hsa051460.94419587
49Shigellosis_Homo sapiens_hsa051310.93020481
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92223528
51VEGF signaling pathway_Homo sapiens_hsa043700.90407553
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.90158295
53Other glycan degradation_Homo sapiens_hsa005110.89373834
54Small cell lung cancer_Homo sapiens_hsa052220.87163903
55Non-small cell lung cancer_Homo sapiens_hsa052230.86748193
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.82551988
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81990345
58Acute myeloid leukemia_Homo sapiens_hsa052210.77174222
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74925838
60Prolactin signaling pathway_Homo sapiens_hsa049170.74824551
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74792630
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73991092
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72771470
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.72183692
65ABC transporters_Homo sapiens_hsa020100.70759390
66Chronic myeloid leukemia_Homo sapiens_hsa052200.70580586
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70221498
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.68818203
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68195810
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67950021
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.67540861
72GnRH signaling pathway_Homo sapiens_hsa049120.65258817
73Renal cell carcinoma_Homo sapiens_hsa052110.65057414
74Choline metabolism in cancer_Homo sapiens_hsa052310.63194750
75MAPK signaling pathway_Homo sapiens_hsa040100.62776515
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61996968
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.60422471
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60143376
79Pancreatic cancer_Homo sapiens_hsa052120.58044674
80Insulin resistance_Homo sapiens_hsa049310.57814924
81mTOR signaling pathway_Homo sapiens_hsa041500.57105742
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.57062365
83Linoleic acid metabolism_Homo sapiens_hsa005910.55913397
84Inositol phosphate metabolism_Homo sapiens_hsa005620.54565774
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53679119
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52911760
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52742766
88Type II diabetes mellitus_Homo sapiens_hsa049300.47302805
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45892017
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.45735773
91Vitamin digestion and absorption_Homo sapiens_hsa049770.44659528
92PPAR signaling pathway_Homo sapiens_hsa033200.43083955
93Oxytocin signaling pathway_Homo sapiens_hsa049210.42921530
94Ovarian steroidogenesis_Homo sapiens_hsa049130.42708729
95ErbB signaling pathway_Homo sapiens_hsa040120.41119317
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41057935
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40722784
98Ether lipid metabolism_Homo sapiens_hsa005650.40120296
99Estrogen signaling pathway_Homo sapiens_hsa049150.39863154
100Platelet activation_Homo sapiens_hsa046110.39411207
101Glycerolipid metabolism_Homo sapiens_hsa005610.38916231
102Tryptophan metabolism_Homo sapiens_hsa003800.38878181
103Peroxisome_Homo sapiens_hsa041460.38564808
104Endometrial cancer_Homo sapiens_hsa052130.37788977
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36803617
106Prion diseases_Homo sapiens_hsa050200.36020068
107Epstein-Barr virus infection_Homo sapiens_hsa051690.35408357
108Histidine metabolism_Homo sapiens_hsa003400.33461849
109MicroRNAs in cancer_Homo sapiens_hsa052060.33246590
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33023999
111Arginine biosynthesis_Homo sapiens_hsa002200.32601413
112FoxO signaling pathway_Homo sapiens_hsa040680.32503155
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32015627
114Starch and sucrose metabolism_Homo sapiens_hsa005000.29819306
115Prostate cancer_Homo sapiens_hsa052150.29718779
116Proteoglycans in cancer_Homo sapiens_hsa052050.28642328
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27702938
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.27247286
119HTLV-I infection_Homo sapiens_hsa051660.25915334
120Viral carcinogenesis_Homo sapiens_hsa052030.25598990
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.25348140
122Chemical carcinogenesis_Homo sapiens_hsa052040.22186418
123Lysine degradation_Homo sapiens_hsa003100.21609923
124Selenocompound metabolism_Homo sapiens_hsa004500.21563467
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21332642
126HIF-1 signaling pathway_Homo sapiens_hsa040660.21101135
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21006798
128Sphingolipid metabolism_Homo sapiens_hsa006000.20784914
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19843400
130Notch signaling pathway_Homo sapiens_hsa043300.19824276

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