CFTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.54424600
2regulation of interleukin-8 secretion (GO:2000482)6.72394284
3regulation of bile acid biosynthetic process (GO:0070857)6.22155971
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.18100019
5intestinal cholesterol absorption (GO:0030299)5.96620158
6cellular copper ion homeostasis (GO:0006878)5.96202821
7copper ion transport (GO:0006825)5.90207946
8negative regulation of complement activation (GO:0045916)5.89562855
9UDP-N-acetylglucosamine metabolic process (GO:0006047)5.85715673
10angiotensin maturation (GO:0002003)5.77971798
11negative regulation of protein activation cascade (GO:2000258)5.56163382
12intestinal epithelial cell development (GO:0060576)5.55705832
13cytidine metabolic process (GO:0046087)5.42499442
14cytidine catabolic process (GO:0006216)5.42499442
15cytidine deamination (GO:0009972)5.42499442
16cobalamin metabolic process (GO:0009235)5.17427414
17O-glycan processing (GO:0016266)5.00454518
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.92697500
193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.92697500
20copper ion homeostasis (GO:0055070)4.90609764
21negative regulation of humoral immune response (GO:0002921)4.67398669
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.66186504
23regulation of chemokine secretion (GO:0090196)4.63584141
24membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.62683937
25actin filament depolymerization (GO:0030042)4.61693355
26nephron tubule formation (GO:0072079)4.60100487
27auditory receptor cell differentiation (GO:0042491)4.57514805
28flavonoid metabolic process (GO:0009812)4.45038432
29maintenance of gastrointestinal epithelium (GO:0030277)4.38062764
30diterpenoid biosynthetic process (GO:0016102)4.27509299
31killing of cells of other organism (GO:0031640)4.26236550
32disruption of cells of other organism (GO:0044364)4.26236550
33glucuronate metabolic process (GO:0019585)4.23707082
34uronic acid metabolic process (GO:0006063)4.23707082
35cellular glucuronidation (GO:0052695)4.23377076
36sulfate transmembrane transport (GO:1902358)4.20473474
37digestive system process (GO:0022600)4.19197846
38membrane repolarization during action potential (GO:0086011)4.16880634
39endocrine pancreas development (GO:0031018)4.11379518
40antibacterial humoral response (GO:0019731)4.09432833
41adenosine metabolic process (GO:0046085)4.06711857
42regulation of apoptotic process involved in morphogenesis (GO:1902337)4.06077493
43tight junction assembly (GO:0070830)4.00858525
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.97602884
45vitamin A metabolic process (GO:0006776)3.94595536
46antimicrobial humoral response (GO:0019730)3.92437545
47negative regulation of interleukin-8 production (GO:0032717)3.92218687
48negative regulation of hormone metabolic process (GO:0032351)3.87449528
49hair cell differentiation (GO:0035315)3.85449976
50drug catabolic process (GO:0042737)3.85255066
51* sperm capacitation (GO:0048240)3.84120974
52regulation of cellular extravasation (GO:0002691)3.83723986
53epithelial structure maintenance (GO:0010669)3.78445620
54* bicarbonate transport (GO:0015701)3.76035464
55pyrimidine-containing compound transmembrane transport (GO:0072531)3.72448835
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70479544
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70479544
58regulation of somitogenesis (GO:0014807)3.68860390
59positive regulation of chemokine secretion (GO:0090197)3.68808679
60negative regulation of keratinocyte proliferation (GO:0010839)3.66875116
61ventricular cardiac muscle cell action potential (GO:0086005)3.66819122
62* transepithelial transport (GO:0070633)3.60493499
63regulation of complement activation (GO:0030449)3.57813388
64positive regulation of digestive system process (GO:0060456)3.54836379
65acute inflammatory response (GO:0002526)3.54055276
66regulation of metalloenzyme activity (GO:0048552)3.53884070
67sulfate transport (GO:0008272)3.51221172
68negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.49785848
69regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.49560228
70regulation of respiratory burst (GO:0060263)3.48948731
71peptide catabolic process (GO:0043171)3.48207334
72inner ear receptor cell differentiation (GO:0060113)3.46516862
73alkaloid metabolic process (GO:0009820)3.44265716
74hepatocyte apoptotic process (GO:0097284)3.44083569
75sulfation (GO:0051923)3.41944104
76nephron epithelium morphogenesis (GO:0072088)3.41670985
77nephron tubule morphogenesis (GO:0072078)3.41670985
78regulation of protein activation cascade (GO:2000257)3.41289476
79virion attachment to host cell (GO:0019062)3.38713578
80adhesion of symbiont to host cell (GO:0044650)3.38713578
81cilium or flagellum-dependent cell motility (GO:0001539)3.37295832
82desmosome organization (GO:0002934)3.37017026
83negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.33740106
84fucose metabolic process (GO:0006004)3.32474378
85regulation of transforming growth factor beta1 production (GO:0032908)3.32277432
86ethanol oxidation (GO:0006069)3.31859847
87thyroid hormone generation (GO:0006590)3.28196796
88regulation of type B pancreatic cell apoptotic process (GO:2000674)3.27504970
89pantothenate metabolic process (GO:0015939)3.26973459
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.26731096
91positive regulation of glycoprotein biosynthetic process (GO:0010560)3.25857238
92sodium ion homeostasis (GO:0055078)3.21885016
93hormone catabolic process (GO:0042447)3.19890615
94thyroid hormone metabolic process (GO:0042403)3.18593933
95proline biosynthetic process (GO:0006561)3.18339484
96nodal signaling pathway (GO:0038092)3.18197076
97negative regulation of coagulation (GO:0050819)3.18191598
98sulfur compound transport (GO:0072348)3.15790807
99citrulline biosynthetic process (GO:0019240)3.14556646
100opsonization (GO:0008228)3.12123194
101primary alcohol catabolic process (GO:0034310)3.10945164
102acute-phase response (GO:0006953)3.10835721
103protein O-linked glycosylation (GO:0006493)3.08028830
104excretion (GO:0007588)3.05714725
105defense response to fungus (GO:0050832)3.02297371
106receptor catabolic process (GO:0032801)3.00039447
107digestion (GO:0007586)2.99964447
108negative regulation of metanephros development (GO:0072217)2.99752494
109antigen processing and presentation of endogenous antigen (GO:0019883)2.99420181
110iron ion import (GO:0097286)2.98695152
111regulation of protein glycosylation (GO:0060049)2.97522932
112cell wall macromolecule metabolic process (GO:0044036)2.97424423
113cell wall macromolecule catabolic process (GO:0016998)2.97424423
114negative regulation of hormone biosynthetic process (GO:0032353)2.95533523
115response to copper ion (GO:0046688)2.94620789
116short-chain fatty acid metabolic process (GO:0046459)2.94003674
117myoblast migration (GO:0051451)2.93129509
118regulation of cholesterol homeostasis (GO:2000188)2.92761482
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92432291
120sequestering of metal ion (GO:0051238)2.91779766
121ethanol metabolic process (GO:0006067)2.91541372
122regulation of heart rate by cardiac conduction (GO:0086091)2.91421371
123lung lobe morphogenesis (GO:0060463)2.90715882
124regulation of transforming growth factor beta2 production (GO:0032909)2.90450971
125hemidesmosome assembly (GO:0031581)2.89895167
126urea metabolic process (GO:0019627)2.87482653
127urea cycle (GO:0000050)2.87482653
128multicellular organismal water homeostasis (GO:0050891)2.86097761
129positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.85458583
130regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.84672759
131fucose catabolic process (GO:0019317)2.82732752
132L-fucose metabolic process (GO:0042354)2.82732752
133L-fucose catabolic process (GO:0042355)2.82732752
134terpenoid biosynthetic process (GO:0016114)2.82377402
135epoxygenase P450 pathway (GO:0019373)2.80335462
136positive regulation of glycolytic process (GO:0045821)2.80135063
137cellular response to vitamin D (GO:0071305)2.79710388
138complement activation, classical pathway (GO:0006958)2.79699282
139nucleotide-sugar metabolic process (GO:0009225)2.78661513
140oxidative demethylation (GO:0070989)2.78512854
141positive regulation of actin filament depolymerization (GO:0030836)2.77427355
142keratinocyte proliferation (GO:0043616)2.76027563
143transcytosis (GO:0045056)2.75441891
144cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74663845
145response to hepatocyte growth factor (GO:0035728)2.74663845
146pericardium development (GO:0060039)2.74328806
147positive regulation of glycoprotein metabolic process (GO:1903020)2.74302716
148pyrimidine nucleoside catabolic process (GO:0046135)2.72412811
149retinal metabolic process (GO:0042574)2.71360953
150innate immune response in mucosa (GO:0002227)2.71232482
151glucose 6-phosphate metabolic process (GO:0051156)2.70837078
152phospholipid homeostasis (GO:0055091)2.69369690
153very-low-density lipoprotein particle assembly (GO:0034379)2.69364322
154nucleotide-sugar biosynthetic process (GO:0009226)2.68662454
155regulation of Golgi to plasma membrane protein transport (GO:0042996)2.68029222
156cell communication involved in cardiac conduction (GO:0086065)2.68010241
157lipid translocation (GO:0034204)2.67560930
158positive regulation of astrocyte differentiation (GO:0048711)2.66548539
159bile acid metabolic process (GO:0008206)2.64614552
160renal tubule morphogenesis (GO:0061333)2.58059785
161regulation of mesenchymal cell apoptotic process (GO:2001053)2.56752579
162drug metabolic process (GO:0017144)2.55563371
163exocrine pancreas development (GO:0031017)2.55422409
164chronic inflammatory response (GO:0002544)2.54529215
165regulation of glucokinase activity (GO:0033131)2.53734903
166regulation of hexokinase activity (GO:1903299)2.53734903
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50543246
168primary alcohol metabolic process (GO:0034308)2.48839306
169nonribosomal peptide biosynthetic process (GO:0019184)2.48722574
170oligosaccharide biosynthetic process (GO:0009312)2.48713643
171regulation of transforming growth factor beta production (GO:0071634)2.48468126
172bile acid and bile salt transport (GO:0015721)2.47556348
173regulation of acrosome reaction (GO:0060046)2.46405568
174artery smooth muscle contraction (GO:0014824)2.45627618
175phenylpropanoid metabolic process (GO:0009698)2.45620298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.87843488
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.31817145
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.89766545
4SOX2_27498859_Chip-Seq_STOMACH_Mouse4.04226612
5* CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.71888893
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.48652571
7GATA4_25053715_ChIP-Seq_YYC3_Human3.27182423
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.18899146
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.05995693
10* SOX2_20726797_ChIP-Seq_SW620_Human3.03731139
11GATA6_25053715_ChIP-Seq_YYC3_Human2.89577307
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.65585048
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30917624
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12621374
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12228788
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97405652
17* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96921624
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.95062692
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.94317525
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90563613
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87280682
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.84242875
23* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.83308421
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.83187953
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82843165
26KLF5_25053715_ChIP-Seq_YYC3_Human1.80811165
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.73902070
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.70275547
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.68719262
30AHR_22903824_ChIP-Seq_MCF-7_Human1.68051750
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.66988011
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.66384810
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.66104460
34AR_21909140_ChIP-Seq_LNCAP_Human1.65742126
35* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.59389996
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.57479038
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.57046073
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55324023
39* GBX2_23144817_ChIP-Seq_PC3_Human1.53163173
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48774916
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48774289
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45074549
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43828669
44* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42501216
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.42187291
46* CDX2_22108803_ChIP-Seq_LS180_Human1.41183906
47* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41024954
48BCAT_22108803_ChIP-Seq_LS180_Human1.39676300
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.39105504
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38905178
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.38097425
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35473675
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35473675
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32251378
55* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31776438
56VDR_22108803_ChIP-Seq_LS180_Human1.31434641
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.30627956
58STAT1_17558387_ChIP-Seq_HELA_Human1.30400686
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29948934
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29683960
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.29095720
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28926338
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23929155
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23178285
65P300_19829295_ChIP-Seq_ESCs_Human1.23081770
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.21855514
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21247446
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20934602
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20851009
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20823017
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.20377598
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.19127937
73SMAD4_21799915_ChIP-Seq_A2780_Human1.18347007
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17902987
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.16191148
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15491612
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15109550
78CJUN_26792858_Chip-Seq_BT549_Human1.14301087
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.13431754
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12849425
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11429910
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.09413183
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08317212
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08196430
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.07842815
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07744433
87RXR_22108803_ChIP-Seq_LS180_Human1.06863632
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03870795
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03870795
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.03160021
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.01458119
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99980974
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99520379
94* TP53_16413492_ChIP-PET_HCT116_Human0.99403590
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99368645
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99253863
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99058560
98NANOG_19829295_ChIP-Seq_ESCs_Human0.98867337
99SOX2_19829295_ChIP-Seq_ESCs_Human0.98867337
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98237890
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97525229
102NANOG_18555785_Chip-Seq_ESCs_Mouse0.97131439
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96450062
104AR_25329375_ChIP-Seq_VCAP_Human0.96346945
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96319502
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.96130991
107ATF3_27146783_Chip-Seq_COLON_Human0.96130979
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.95719208
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95612738
110PHF8_20622853_ChIP-Seq_HELA_Human0.95271038
111* STAT3_23295773_ChIP-Seq_U87_Human0.94865771
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94036351
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93965944
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93908440
115TP53_18474530_ChIP-ChIP_U2OS_Human0.93633230
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92747652
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.92269359
118* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91213196
119TP63_23658742_ChIP-Seq_EP156T_Human0.90929940
120TCF4_22108803_ChIP-Seq_LS180_Human0.89514880
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89142681
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88676105
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86972080
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.86522243
125* PIAS1_25552417_ChIP-Seq_VCAP_Human0.86514610
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85989348
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.85212778
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.85022234
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84354075
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83400203
131FUS_26573619_Chip-Seq_HEK293_Human0.81256284
132ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.80916079
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80651459
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80477172
135* KDM2B_26808549_Chip-Seq_REH_Human0.80294908
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80086912
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79014333
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78990570
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78387034
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78351927
141CBP_20019798_ChIP-Seq_JUKART_Human0.78228514
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78228514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.21759561
2MP0005360_urolithiasis4.66259556
3MP0001666_abnormal_nutrient_absorption3.72028008
4MP0003195_calcinosis3.59068003
5MP0004885_abnormal_endolymph3.54047764
6MP0001485_abnormal_pinna_reflex3.39397214
7MP0003866_abnormal_defecation3.13059753
8MP0002876_abnormal_thyroid_physiology3.08738400
9MP0008004_abnormal_stomach_pH3.08134440
10* MP0000462_abnormal_digestive_system3.04290949
11MP0004264_abnormal_extraembryonic_tissu2.98319704
12MP0005085_abnormal_gallbladder_physiolo2.83372254
13MP0002139_abnormal_hepatobiliary_system2.76438058
14MP0000537_abnormal_urethra_morphology2.68677744
15MP0005408_hypopigmentation2.55451461
16MP0009379_abnormal_foot_pigmentation2.54898538
17MP0000566_synostosis2.35305194
18MP0010155_abnormal_intestine_physiology2.26803794
19MP0003252_abnormal_bile_duct2.18681353
20* MP0001663_abnormal_digestive_system2.18181882
21* MP0005220_abnormal_exocrine_pancreas2.16181783
22* MP0005381_digestive/alimentary_phenotyp2.16142991
23MP0003941_abnormal_skin_development2.10402326
24MP0004782_abnormal_surfactant_physiolog2.06540898
25MP0003045_fibrosis2.06505970
26MP0000490_abnormal_crypts_of2.06269087
27MP0001873_stomach_inflammation2.03008558
28MP0009697_abnormal_copulation1.93090254
29MP0000569_abnormal_digit_pigmentation1.90579913
30MP0002098_abnormal_vibrissa_morphology1.90086314
31MP0003950_abnormal_plasma_membrane1.81574798
32* MP0001664_abnormal_digestion1.79489623
33MP0002822_catalepsy1.77105255
34MP0000538_abnormal_urinary_bladder1.73035184
35MP0010352_gastrointestinal_tract_polyps1.71358732
36MP0010678_abnormal_skin_adnexa1.69399659
37MP0003878_abnormal_ear_physiology1.68719599
38MP0005377_hearing/vestibular/ear_phenot1.68719599
39MP0004147_increased_porphyrin_level1.65459139
40* MP0000477_abnormal_intestine_morphology1.61720055
41MP0005365_abnormal_bile_salt1.59660692
42MP0003943_abnormal_hepatobiliary_system1.58579248
43MP0004043_abnormal_pH_regulation1.57132251
44MP0009643_abnormal_urine_homeostasis1.53416791
45MP0004019_abnormal_vitamin_homeostasis1.51396856
46MP0010386_abnormal_urinary_bladder1.49557844
47MP0008875_abnormal_xenobiotic_pharmacok1.49109420
48MP0006054_spinal_hemorrhage1.48901397
49MP0003183_abnormal_peptide_metabolism1.43641682
50MP0001765_abnormal_ion_homeostasis1.42597091
51MP0002168_other_aberrant_phenotype1.41908036
52MP0005636_abnormal_mineral_homeostasis1.41489960
53MP0009840_abnormal_foam_cell1.38111208
54* MP0008872_abnormal_physiological_respon1.32839703
55MP0005167_abnormal_blood-brain_barrier1.31762204
56MP0002138_abnormal_hepatobiliary_system1.29210755
57* MP0005410_abnormal_fertilization1.28275459
58MP0001756_abnormal_urination1.27697700
59MP0002254_reproductive_system_inflammat1.26903070
60MP0009053_abnormal_anal_canal1.26615751
61MP0003453_abnormal_keratinocyte_physiol1.21892574
62MP0005023_abnormal_wound_healing1.21855192
63MP0005670_abnormal_white_adipose1.16236392
64MP0010329_abnormal_lipoprotein_level1.15157846
65MP0002796_impaired_skin_barrier1.13913156
66MP0005166_decreased_susceptibility_to1.12827205
67MP0003718_maternal_effect1.12616652
68MP0003724_increased_susceptibility_to1.10075742
69MP0002136_abnormal_kidney_physiology1.05043073
70MP0000470_abnormal_stomach_morphology1.03557158
71MP0005084_abnormal_gallbladder_morpholo1.02335770
72MP0001849_ear_inflammation0.99647170
73MP0005171_absent_coat_pigmentation0.99468351
74MP0009785_altered_susceptibility_to0.98043062
75MP0003119_abnormal_digestive_system0.94487936
76MP0002009_preneoplasia0.94100386
77MP0005319_abnormal_enzyme/_coenzyme0.91566956
78* MP0001944_abnormal_pancreas_morphology0.90815002
79MP0009780_abnormal_chondrocyte_physiolo0.88155001
80* MP0001177_atelectasis0.87971644
81MP0000383_abnormal_hair_follicle0.87866229
82MP0003959_abnormal_lean_body0.87422999
83MP0005083_abnormal_biliary_tract0.87389795
84MP0004742_abnormal_vestibular_system0.87279042
85* MP0002133_abnormal_respiratory_system0.86335526
86* MP0005388_respiratory_system_phenotype0.86335526
87MP0003868_abnormal_feces_composition0.83534605
88* MP0003300_gastrointestinal_ulcer0.82371322
89MP0005174_abnormal_tail_pigmentation0.81868393
90* MP0002118_abnormal_lipid_homeostasis0.77345809
91MP0003953_abnormal_hormone_level0.76683331
92MP0002060_abnormal_skin_morphology0.76215019
93MP0005248_abnormal_Harderian_gland0.76190938
94MP0002127_abnormal_cardiovascular_syste0.76137424
95MP0005501_abnormal_skin_physiology0.74679649
96MP0001963_abnormal_hearing_physiology0.74603487
97MP0009384_cardiac_valve_regurgitation0.73648964
98MP0003115_abnormal_respiratory_system0.73391725
99MP0004272_abnormal_basement_membrane0.72886185
100MP0003693_abnormal_embryo_hatching0.72734807
101MP0000467_abnormal_esophagus_morphology0.71259643
102MP0005395_other_phenotype0.70680110
103MP0000372_irregular_coat_pigmentation0.69796342
104MP0000371_diluted_coat_color0.69630212
105MP0000230_abnormal_systemic_arterial0.68592900
106MP0005367_renal/urinary_system_phenotyp0.67849848
107MP0000516_abnormal_urinary_system0.67849848
108MP0005332_abnormal_amino_acid0.67368756
109MP0002295_abnormal_pulmonary_circulatio0.66711852
110MP0003787_abnormal_imprinting0.65483173
111MP0003705_abnormal_hypodermis_morpholog0.65286150
112MP0002928_abnormal_bile_duct0.64575469
113MP0000013_abnormal_adipose_tissue0.62123180
114MP0001216_abnormal_epidermal_layer0.61860315
115MP0005310_abnormal_salivary_gland0.61566001
116MP0005595_abnormal_vascular_smooth0.61503882
117MP0002693_abnormal_pancreas_physiology0.60498379
118MP0009764_decreased_sensitivity_to0.60270827
119MP0005448_abnormal_energy_balance0.59939594
120MP0003283_abnormal_digestive_organ0.59558905
121MP0005187_abnormal_penis_morphology0.58766450
122MP0004957_abnormal_blastocyst_morpholog0.58392017
123MP0002909_abnormal_adrenal_gland0.58192651
124* MP0003698_abnormal_male_reproductive0.56770730
125* MP0001929_abnormal_gametogenesis0.56130746
126MP0002653_abnormal_ependyma_morphology0.53939183
127MP0005165_increased_susceptibility_to0.51736103
128MP0002078_abnormal_glucose_homeostasis0.51381605
129MP0003806_abnormal_nucleotide_metabolis0.46958113
130* MP0000613_abnormal_salivary_gland0.46720434
131MP0000609_abnormal_liver_physiology0.46660834
132* MP0001845_abnormal_inflammatory_respons0.42378433
133MP0001764_abnormal_homeostasis0.39359268
134MP0002135_abnormal_kidney_morphology0.38572460
135MP0009642_abnormal_blood_homeostasis0.38048162
136MP0001984_abnormal_olfaction0.35601968
137MP0004133_heterotaxia0.35000192
138MP0004085_abnormal_heartbeat0.34628287
139MP0004484_altered_response_of0.34001851
140MP0008469_abnormal_protein_level0.32706572
141MP0009703_decreased_birth_body0.32223218
142MP0001501_abnormal_sleep_pattern0.31926290
143MP0000377_abnormal_hair_follicle0.30605914
144MP0000598_abnormal_liver_morphology0.30033915

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.13558471
2Morphological abnormality of the inner ear (HP:0011390)7.11352452
3Chronic bronchitis (HP:0004469)6.31734442
4Conjugated hyperbilirubinemia (HP:0002908)6.07651028
5Hyperaldosteronism (HP:0000859)5.60446997
6Hypokalemic alkalosis (HP:0001949)5.57093647
7* Abnormality of chloride homeostasis (HP:0011422)5.37573495
8* Exocrine pancreatic insufficiency (HP:0001738)5.12995582
9Renal salt wasting (HP:0000127)5.12167032
10Right ventricular cardiomyopathy (HP:0011663)5.01628801
11* Ileus (HP:0002595)4.85496851
12Decreased circulating renin level (HP:0003351)4.79952020
13Ventricular fibrillation (HP:0001663)4.48356993
14Metabolic alkalosis (HP:0200114)4.41545157
15Late onset (HP:0003584)4.28652498
16Alkalosis (HP:0001948)4.16654846
17Hyponatremia (HP:0002902)4.06444028
18Gout (HP:0001997)4.02137229
19Steatorrhea (HP:0002570)3.98300485
20Glycosuria (HP:0003076)3.78777564
21Abnormality of urine glucose concentration (HP:0011016)3.78777564
22Hyperkalemia (HP:0002153)3.70765678
23Renal tubular acidosis (HP:0001947)3.68175288
24Abnormality of renin-angiotensin system (HP:0000847)3.65277847
25Mitral stenosis (HP:0001718)3.46184055
26Potter facies (HP:0002009)3.39149821
27Facial shape deformation (HP:0011334)3.39149821
28Hyperparathyroidism (HP:0000843)3.30874779
29Congenital sensorineural hearing impairment (HP:0008527)3.29593621
30Flattened epiphyses (HP:0003071)3.29266893
31Insulin-resistant diabetes mellitus (HP:0000831)3.24894537
32Woolly hair (HP:0002224)3.19363651
33Abnormality of sodium homeostasis (HP:0010931)3.15587974
34Chronic diarrhea (HP:0002028)3.12053420
35Aplasia/hypoplasia of the uterus (HP:0008684)3.06223345
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05851929
37Abnormality of the nasal septum (HP:0000419)3.05094880
38Hypokalemia (HP:0002900)3.01805194
39Unilateral renal agenesis (HP:0000122)3.01496504
40Acanthocytosis (HP:0001927)2.98561101
41Pustule (HP:0200039)2.96036005
42Hyperphosphaturia (HP:0003109)2.95130415
43Goiter (HP:0000853)2.94630841
44Malnutrition (HP:0004395)2.90571463
45Vascular calcification (HP:0004934)2.89600855
46* Dehydration (HP:0001944)2.86447374
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84953629
48Adrenal overactivity (HP:0002717)2.84914835
49Glucose intolerance (HP:0000833)2.78703695
50Abnormal hemoglobin (HP:0011902)2.76281790
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73089113
52Insulin resistance (HP:0000855)2.69391459
53Enlarged kidneys (HP:0000105)2.67062475
54Abdominal distention (HP:0003270)2.66816914
55Increased circulating renin level (HP:0000848)2.64019802
56Osteomalacia (HP:0002749)2.63207746
57Cardiovascular calcification (HP:0011915)2.59133157
58Abnormality of potassium homeostasis (HP:0011042)2.55960105
59Barrel-shaped chest (HP:0001552)2.54896345
60Abnormality of the middle phalanges of the toes (HP:0010183)2.51881078
61Irregular vertebral endplates (HP:0003301)2.50427334
62Abnormality of vitamin metabolism (HP:0100508)2.49799439
63Tubulointerstitial fibrosis (HP:0005576)2.49301262
64Esophageal varix (HP:0002040)2.48588662
65Bronchitis (HP:0012387)2.48128105
66Tracheal stenosis (HP:0002777)2.47295532
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.46661688
68Abnormal urine phosphate concentration (HP:0012599)2.46413259
69Onycholysis (HP:0001806)2.43580963
70Hypotension (HP:0002615)2.37344426
71Systemic lupus erythematosus (HP:0002725)2.36608833
72Vertebral arch anomaly (HP:0008438)2.36233699
73Small epiphyses (HP:0010585)2.36158956
74Abnormality of vitamin B metabolism (HP:0004340)2.35111482
75Abnormality of the gastric mucosa (HP:0004295)2.35102980
76Large for gestational age (HP:0001520)2.30104573
77Neonatal death (HP:0003811)2.29847871
78Villous atrophy (HP:0011473)2.24381344
79Abnormality of small intestinal villus morphology (HP:0011472)2.24381344
80Autoimmune hemolytic anemia (HP:0001890)2.22371781
81Hypomagnesemia (HP:0002917)2.22281397
82* Bronchiectasis (HP:0002110)2.20045501
83Metabolic acidosis (HP:0001942)2.18533229
84Bicornuate uterus (HP:0000813)2.18061626
85Pancreatic cysts (HP:0001737)2.16160224
86Hypobetalipoproteinemia (HP:0003563)2.14700536
87Hypoplasia of the uterus (HP:0000013)2.14413423
88Tetraparesis (HP:0002273)2.12914171
89Abnormality of the vitamin B12 metabolism (HP:0004341)2.11109271
90Renal tubular dysfunction (HP:0000124)2.09754538
91Abnormality of renal excretion (HP:0011036)2.09284493
92Increased purine levels (HP:0004368)2.08106759
93Hyperuricemia (HP:0002149)2.08106759
94Micronodular cirrhosis (HP:0001413)2.06658124
95Biliary tract neoplasm (HP:0100574)2.06603385
96Pili torti (HP:0003777)2.06415205
97Arthropathy (HP:0003040)2.05601069
98Ureteral obstruction (HP:0006000)2.05099860
99Curly hair (HP:0002212)2.03146800
100Widely spaced teeth (HP:0000687)2.02554181
101Portal hypertension (HP:0001409)2.02537773
102Ankyloglossia (HP:0010296)2.02518318
103Syncope (HP:0001279)2.00453447
104Abnormality of cochlea (HP:0000375)10.4776945
105Hypoproteinemia (HP:0003075)1.98627146
106Tinnitus (HP:0000360)1.98308981
107Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.98255777
108Progressive sensorineural hearing impairment (HP:0000408)1.98011559
109Pigmentary retinal degeneration (HP:0001146)1.97558367
110Increased CSF protein (HP:0002922)1.96786869
111Fragile skin (HP:0001030)1.95956239
112Abnormal respiratory motile cilium physiology (HP:0012261)1.95209265
113Vertebral clefting (HP:0008428)1.94664662
114Fat malabsorption (HP:0002630)1.93564577
115Thickened helices (HP:0000391)1.91406916
116Abnormality of magnesium homeostasis (HP:0004921)1.91326028
117Cystic liver disease (HP:0006706)1.90683503
118Abnormality of renal resorption (HP:0011038)1.88687631
119Xerostomia (HP:0000217)1.88299263
120Wide intermamillary distance (HP:0006610)1.87996511
121Flat acetabular roof (HP:0003180)1.87620096
122Abnormality of the renal medulla (HP:0100957)1.87058934
123* Abnormal biliary tract morphology (HP:0012440)1.87055991
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.86488564
125Absent/shortened dynein arms (HP:0200106)1.86488564
126Palpitations (HP:0001962)1.85852150
127Increased hepatocellular lipid droplets (HP:0006565)1.84977774
128Lipid accumulation in hepatocytes (HP:0006561)1.84682392
129Ventricular arrhythmia (HP:0004308)1.83401907
130Limited hip movement (HP:0008800)1.83394592
131Shawl scrotum (HP:0000049)1.82827899
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82686430
133Complement deficiency (HP:0004431)1.81859279
134Glomerulonephritis (HP:0000099)1.81406694
135Abnormality of the vertebral endplates (HP:0005106)1.81381736
136Abnormality of the hepatic vasculature (HP:0006707)1.79697086
137Milia (HP:0001056)1.79177799
138Nephrolithiasis (HP:0000787)1.78562418
139Intrahepatic cholestasis (HP:0001406)1.78169319
140Tubulointerstitial nephritis (HP:0001970)1.77188899
141Abnormality of the renal cortex (HP:0011035)1.76186906
142Abnormal glucose tolerance (HP:0001952)1.75580481
143Hypothermia (HP:0002045)1.74822485
144Abnormality of proline metabolism (HP:0010907)1.73135741
145Hydroxyprolinuria (HP:0003080)1.73135741
146Widely patent fontanelles and sutures (HP:0004492)1.72529214
147Scotoma (HP:0000575)1.71556411
148Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71410119
149Neonatal short-limb short stature (HP:0008921)1.71090704
150Breast carcinoma (HP:0003002)1.67952849
151Arterial tortuosity (HP:0005116)1.67889210
152Nephropathy (HP:0000112)1.67838346
153Thin bony cortex (HP:0002753)1.66365820
154Hypoplastic labia majora (HP:0000059)1.66138625
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65380796
156Increased intramyocellular lipid droplets (HP:0012240)1.65226953
157Increased muscle lipid content (HP:0009058)1.65128464
158Hepatitis (HP:0012115)1.64596167
159Abnormal pancreas size (HP:0012094)1.63208105
160Tubulointerstitial abnormality (HP:0001969)1.61605611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.15823821
2MST1R3.81177009
3STK393.45450401
4MST43.44893784
5NUAK13.43918564
6MAP4K22.65226924
7MAP3K122.61669649
8TESK12.52763517
9ACVR1B2.48262296
10* PRKG22.46604548
11PDK42.40084272
12PDK32.40084272
13NME12.39400190
14MAP3K22.35099289
15PDK22.29147474
16EPHB22.02057396
17NLK1.99059887
18LATS11.96857381
19TTK1.87395092
20PRKCQ1.85020069
21PBK1.81647073
22RIPK11.75639922
23MAP2K21.69677469
24TNIK1.67239791
25ERBB21.66995730
26OXSR11.63229913
27STK38L1.57140658
28INSRR1.53147083
29WNK41.52452060
30EPHA21.46629721
31MAP2K61.43779233
32TAOK31.42906258
33PTK61.39551024
34EIF2AK31.23990004
35PIK3CA1.22905891
36MAPK111.21700593
37MAP3K31.21400723
38HIPK21.15992953
39EPHA31.14936456
40GRK11.11113576
41CASK1.08454382
42CDK81.07808010
43MYLK1.04537254
44STK101.00717728
45MET1.00022231
46DAPK20.99023667
47STK30.98454573
48FGFR20.98161217
49ZAK0.98010932
50* LMTK20.91883405
51PAK40.91471807
52AURKB0.89464902
53MAP3K110.89421124
54RPS6KB20.87091343
55SRPK10.85085285
56GRK60.84308096
57AKT30.83136247
58IKBKB0.81508249
59FER0.79163280
60PHKG10.73224799
61PHKG20.73224799
62MAP3K80.72652816
63PRKAA20.71813556
64BCR0.71182300
65VRK20.71136296
66TAOK10.71120421
67MAPKAPK30.70955361
68NEK60.69219767
69ADRBK20.67932453
70PTK20.65082170
71FGFR30.64854503
72SCYL20.64010049
73PAK30.63718923
74BRSK20.63684527
75MAP2K10.63340675
76DAPK10.63171794
77FGFR10.61152452
78DYRK1B0.60825965
79IRAK10.60492647
80STK380.57290171
81PRKCI0.56052093
82TRPM70.56029883
83PINK10.55945257
84PASK0.54416699
85EIF2AK10.54369428
86PNCK0.54329931
87MAPK150.52801516
88ERBB30.52569258
89CDK90.52254562
90STK240.49333627
91STK110.48599957
92CDK60.46440722
93DDR20.44034539
94* PRKACG0.43116755
95PRKD30.42957563
96NEK20.41532613
97DMPK0.41277711
98KSR10.41201975
99LRRK20.40637219
100PRKCE0.40314376
101SGK20.40227824
102PKN20.39348659
103PAK10.37728032
104LIMK10.37220534
105MELK0.36256090
106DYRK30.35574529
107MAP3K100.34499017
108CAMK2D0.33579009
109PDGFRA0.29197605
110MAP3K10.28895783
111ERBB40.28845587
112EPHB10.28490782
113CSNK1D0.28460346
114PRKCZ0.27846116
115ADRBK10.26625412
116GSK3A0.26592825
117PDK10.26261325
118* PRKCA0.25785300
119BMPR1B0.25736123
120RPS6KA40.25447447
121* PRKACA0.25094334
122CHEK20.24859360
123YES10.24374133
124BRD40.23048080
125MAP3K70.22897339
126DAPK30.22352337
127PDPK10.21996938
128CAMK2B0.21925083
129MAPKAPK50.21571361
130IGF1R0.21539882
131MATK0.21335372
132KSR20.21283144
133SRC0.21072054
134FGFR40.20998127
135CAMK2A0.20705329
136TGFBR10.20597908
137PLK10.20284737
138CSNK1E0.19553154
139PDGFRB0.18817349
140PIK3CG0.17948610
141BMX0.17687978
142PRKCD0.17270707
143NEK10.16702768
144SGK30.16329294
145AKT20.15769565
146CAMK2G0.15502646
147CSNK1A10.14591135
148CDC42BPA0.14570281
149* PRKAA10.14423304
150TTN0.14149114
151ERN10.13535483
152* ATM0.13249351
153CHUK0.12315973

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049785.85184761
2Sulfur metabolism_Homo sapiens_hsa009203.84229251
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.59075183
4Fat digestion and absorption_Homo sapiens_hsa049753.54811598
5Renin-angiotensin system_Homo sapiens_hsa046143.07150213
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.97368751
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.59485470
8Nitrogen metabolism_Homo sapiens_hsa009102.26668602
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25719981
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.05905757
11Vitamin digestion and absorption_Homo sapiens_hsa049772.03935397
12Protein digestion and absorption_Homo sapiens_hsa049741.96564117
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95725157
14Galactose metabolism_Homo sapiens_hsa000521.93321045
15Starch and sucrose metabolism_Homo sapiens_hsa005001.89642106
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85759849
17Folate biosynthesis_Homo sapiens_hsa007901.82504340
18Histidine metabolism_Homo sapiens_hsa003401.78624995
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78168515
20Fructose and mannose metabolism_Homo sapiens_hsa000511.73448867
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69474721
22Glycerolipid metabolism_Homo sapiens_hsa005611.61317693
23Phenylalanine metabolism_Homo sapiens_hsa003601.59739048
24Fatty acid degradation_Homo sapiens_hsa000711.53912829
25* Bile secretion_Homo sapiens_hsa049761.51502334
26Glutathione metabolism_Homo sapiens_hsa004801.44333630
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43924739
28Tight junction_Homo sapiens_hsa045301.39171679
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34645346
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33766951
31Tryptophan metabolism_Homo sapiens_hsa003801.33191649
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32864114
33Complement and coagulation cascades_Homo sapiens_hsa046101.28074996
34Tyrosine metabolism_Homo sapiens_hsa003501.27284990
35Oxidative phosphorylation_Homo sapiens_hsa001901.24820614
36Circadian rhythm_Homo sapiens_hsa047101.21134983
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19825823
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18629519
39Selenocompound metabolism_Homo sapiens_hsa004501.16152812
40Pyruvate metabolism_Homo sapiens_hsa006201.12934027
41Adherens junction_Homo sapiens_hsa045201.12448157
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09880588
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08237703
44Caffeine metabolism_Homo sapiens_hsa002321.06030654
45Pentose phosphate pathway_Homo sapiens_hsa000301.03483591
46Taste transduction_Homo sapiens_hsa047421.00218443
47Dorso-ventral axis formation_Homo sapiens_hsa043200.98629524
48Huntingtons disease_Homo sapiens_hsa050160.97484031
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96047358
50Parkinsons disease_Homo sapiens_hsa050120.95611754
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.95270082
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92776736
53Ether lipid metabolism_Homo sapiens_hsa005650.92169225
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.92110232
55Propanoate metabolism_Homo sapiens_hsa006400.91617415
56Alzheimers disease_Homo sapiens_hsa050100.89997593
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88413340
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83793611
59Carbon metabolism_Homo sapiens_hsa012000.81919630
60* Pancreatic secretion_Homo sapiens_hsa049720.81259270
61Arginine and proline metabolism_Homo sapiens_hsa003300.81255313
62Thyroid hormone synthesis_Homo sapiens_hsa049180.80262979
63Renin secretion_Homo sapiens_hsa049240.77139625
64* Vibrio cholerae infection_Homo sapiens_hsa051100.76835881
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75420313
66Chemical carcinogenesis_Homo sapiens_hsa052040.75297517
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.69924710
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66061265
69Ribosome_Homo sapiens_hsa030100.64653844
70Salmonella infection_Homo sapiens_hsa051320.64188547
71Salivary secretion_Homo sapiens_hsa049700.62427829
72PPAR signaling pathway_Homo sapiens_hsa033200.62314603
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60361716
74Arginine biosynthesis_Homo sapiens_hsa002200.59111094
75Insulin secretion_Homo sapiens_hsa049110.58996940
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57201050
77Arachidonic acid metabolism_Homo sapiens_hsa005900.56975887
78Influenza A_Homo sapiens_hsa051640.56265332
79beta-Alanine metabolism_Homo sapiens_hsa004100.55060422
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.53243238
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.53226346
82Sphingolipid metabolism_Homo sapiens_hsa006000.52229965
83Metabolic pathways_Homo sapiens_hsa011000.49376995
84Collecting duct acid secretion_Homo sapiens_hsa049660.46723711
85Hippo signaling pathway_Homo sapiens_hsa043900.46686020
86Hepatitis C_Homo sapiens_hsa051600.46522247
87Linoleic acid metabolism_Homo sapiens_hsa005910.45574150
88Butanoate metabolism_Homo sapiens_hsa006500.45506140
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.45234223
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45104046
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43409089
92Retinol metabolism_Homo sapiens_hsa008300.43163563
93* ABC transporters_Homo sapiens_hsa020100.42627908
94Ovarian steroidogenesis_Homo sapiens_hsa049130.41036550
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41023325
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40073939
97TGF-beta signaling pathway_Homo sapiens_hsa043500.38699839
98Thyroid cancer_Homo sapiens_hsa052160.38270150
99* Gastric acid secretion_Homo sapiens_hsa049710.38040867
100Purine metabolism_Homo sapiens_hsa002300.36288346
101N-Glycan biosynthesis_Homo sapiens_hsa005100.34230382
102Bladder cancer_Homo sapiens_hsa052190.31633211
103Fatty acid metabolism_Homo sapiens_hsa012120.31621471
104Fatty acid biosynthesis_Homo sapiens_hsa000610.29360025
105Lysine degradation_Homo sapiens_hsa003100.27852791
106ECM-receptor interaction_Homo sapiens_hsa045120.27045305
107Steroid biosynthesis_Homo sapiens_hsa001000.26238090
108Cardiac muscle contraction_Homo sapiens_hsa042600.26222144
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25828759
110Other glycan degradation_Homo sapiens_hsa005110.24278744
111Biosynthesis of amino acids_Homo sapiens_hsa012300.23946939
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22677946
113Type II diabetes mellitus_Homo sapiens_hsa049300.22667207
114Peroxisome_Homo sapiens_hsa041460.22646889
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21777039
116Endometrial cancer_Homo sapiens_hsa052130.20204101
117Basal cell carcinoma_Homo sapiens_hsa052170.19973844
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16800920
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16498151
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.14628401
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14596465
122African trypanosomiasis_Homo sapiens_hsa051430.13620162
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10648886
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09200747
125Insulin resistance_Homo sapiens_hsa049310.08519985
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.06663110
127Pertussis_Homo sapiens_hsa051330.05937694
128Phototransduction_Homo sapiens_hsa047440.03862245
129Glucagon signaling pathway_Homo sapiens_hsa049220.03563014
130Rheumatoid arthritis_Homo sapiens_hsa053230.02442491

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