CGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)9.05217060
2mating behavior (GO:0007617)8.33757253
3regulation of secondary heart field cardioblast proliferation (GO:0003266)8.08612953
4regulation of cardioblast proliferation (GO:0003264)8.08612953
5receptor guanylyl cyclase signaling pathway (GO:0007168)7.74817733
6homocysteine metabolic process (GO:0050667)7.29426872
7mitotic chromosome condensation (GO:0007076)7.06721423
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.35264097
9endothelial cell proliferation (GO:0001935)6.33934090
10positive regulation of hair follicle development (GO:0051798)6.26292202
11positive regulation of hair cycle (GO:0042635)6.26292202
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.24459176
13response to follicle-stimulating hormone (GO:0032354)6.14985231
14regulation of natural killer cell differentiation (GO:0032823)6.14389158
15nuclear pore complex assembly (GO:0051292)6.13333565
16sister chromatid segregation (GO:0000819)6.08462145
17positive regulation of male gonad development (GO:2000020)5.89587254
18negative regulation of blood vessel endothelial cell migration (GO:0043537)5.88315431
19sprouting angiogenesis (GO:0002040)5.82311947
20citrulline biosynthetic process (GO:0019240)5.75586326
21female pregnancy (GO:0007565)5.72570637
22nuclear pore organization (GO:0006999)5.54353722
23L-alpha-amino acid transmembrane transport (GO:1902475)5.51950241
24hepatocyte differentiation (GO:0070365)5.23997144
25negative regulation of histone methylation (GO:0031061)5.20636703
26regulation of DNA endoreduplication (GO:0032875)5.19857957
27mitotic sister chromatid segregation (GO:0000070)5.17091462
28cGMP biosynthetic process (GO:0006182)5.12295985
29urea cycle (GO:0000050)5.09315852
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.99133815
31regulation of male gonad development (GO:2000018)4.96585763
32blood vessel maturation (GO:0001955)4.93564434
33metanephric mesenchyme development (GO:0072075)4.86814789
34DNA unwinding involved in DNA replication (GO:0006268)4.74790921
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.74335261
36positive regulation of blood vessel endothelial cell migration (GO:0043536)4.69998341
37DNA replication initiation (GO:0006270)4.68701810
38negative regulation of activin receptor signaling pathway (GO:0032926)4.67985928
39pore complex assembly (GO:0046931)4.64722110
40estrogen metabolic process (GO:0008210)4.64583796
41androgen biosynthetic process (GO:0006702)4.58671459
42midgut development (GO:0007494)4.56368775
43attachment of spindle microtubules to kinetochore (GO:0008608)4.55656758
44urea metabolic process (GO:0019627)4.54341830
45ganglion development (GO:0061548)4.51307963
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.43719369
47chromosome condensation (GO:0030261)4.41017331
48detection of external biotic stimulus (GO:0098581)4.36995476
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.32886460
50proline transport (GO:0015824)4.29180939
51ER overload response (GO:0006983)4.27369795
52regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.26960568
53kidney mesenchyme development (GO:0072074)4.23091097
54translesion synthesis (GO:0019985)4.22872320
55protein retention in ER lumen (GO:0006621)4.20569225
56citrulline metabolic process (GO:0000052)4.20135462
57glucocorticoid biosynthetic process (GO:0006704)4.18267571
58protein localization to kinetochore (GO:0034501)4.16552282
59phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.16267408
60induction of positive chemotaxis (GO:0050930)4.16000517
61pharyngeal system development (GO:0060037)4.13885579
62negative regulation of complement activation (GO:0045916)4.08084885
63sister chromatid cohesion (GO:0007062)4.07481093
64myoblast migration (GO:0051451)4.07223478
65multi-multicellular organism process (GO:0044706)4.04330385
66phosphatidylinositol acyl-chain remodeling (GO:0036149)4.03528391
67nitrogen cycle metabolic process (GO:0071941)4.03089433
68Golgi transport vesicle coating (GO:0048200)3.99616273
69COPI coating of Golgi vesicle (GO:0048205)3.99616273
70regulation of histone H3-K9 methylation (GO:0051570)3.98375471
71trabecula formation (GO:0060343)3.97201877
72regulation of gonadotropin secretion (GO:0032276)3.95634091
73syncytium formation (GO:0006949)3.91473954
74microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.90936976
75reproductive behavior (GO:0019098)3.90412555
76vitamin transmembrane transport (GO:0035461)3.88030831
77nephron tubule formation (GO:0072079)3.85352726
78regulation of mitotic spindle organization (GO:0060236)3.82984545
79necroptotic process (GO:0070266)3.82245873
80spindle assembly involved in mitosis (GO:0090307)3.81947477
81iron ion import (GO:0097286)3.81010121
82tooth mineralization (GO:0034505)3.79759188
83establishment of mitotic spindle localization (GO:0040001)3.79412491
84regulation of hair follicle development (GO:0051797)3.78768513
85multi-organism reproductive behavior (GO:0044705)3.78027950
86wound healing, spreading of epidermal cells (GO:0035313)3.77554737
87establishment of nucleus localization (GO:0040023)3.73519211
88kinetochore organization (GO:0051383)3.72515337
89negative regulation of endothelial cell migration (GO:0010596)3.70774218
90retina vasculature morphogenesis in camera-type eye (GO:0061299)3.65649630
91alanine transport (GO:0032328)3.62402478
92protein localization to chromosome, centromeric region (GO:0071459)3.61979185
93regulation of centriole replication (GO:0046599)3.61425094
94multi-organism reproductive process (GO:0044703)3.61160192
95positive regulation of cGMP biosynthetic process (GO:0030828)3.56495708
96negative regulation of protein activation cascade (GO:2000258)3.56158637
97phosphatidylserine acyl-chain remodeling (GO:0036150)3.55011153
98pre-miRNA processing (GO:0031054)3.54282811
99chromatin remodeling at centromere (GO:0031055)3.51367000
100detection of biotic stimulus (GO:0009595)3.50486487
101DNA packaging (GO:0006323)3.50273060
102anatomical structure arrangement (GO:0048532)3.50261736
103macroautophagy (GO:0016236)3.49099804
104chromosome segregation (GO:0007059)3.48777903
105regulation of cellular extravasation (GO:0002691)3.46770761
106mitotic nuclear envelope disassembly (GO:0007077)3.45988434
107dosage compensation (GO:0007549)3.45503442
108androgen metabolic process (GO:0008209)3.44993232
109regulation of translational termination (GO:0006449)3.44867607
110CENP-A containing nucleosome assembly (GO:0034080)3.44782811
111ribosome assembly (GO:0042255)3.43332507
112polarized epithelial cell differentiation (GO:0030859)3.42754592
113DNA topological change (GO:0006265)3.42558737
114response to insecticide (GO:0017085)3.41633358
115cellular response to antibiotic (GO:0071236)3.39637187
116postreplication repair (GO:0006301)3.33988090
117branching involved in salivary gland morphogenesis (GO:0060445)3.32361360
118C21-steroid hormone biosynthetic process (GO:0006700)3.31757078
119regulation of cGMP biosynthetic process (GO:0030826)3.31305304
120cGMP metabolic process (GO:0046068)3.30487400
121SMAD protein complex assembly (GO:0007183)3.29895021
122cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.29266052
123negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.29143945
124positive regulation of dendritic spine morphogenesis (GO:0061003)3.25778454
125eosinophil chemotaxis (GO:0048245)3.25585976
126DNA replication-independent nucleosome assembly (GO:0006336)3.22960595
127DNA replication-independent nucleosome organization (GO:0034724)3.22960595
128axon extension involved in axon guidance (GO:0048846)3.21701517
129neuron projection extension involved in neuron projection guidance (GO:1902284)3.21701517
130prostate gland growth (GO:0060736)3.19818415
131membrane disassembly (GO:0030397)3.18278413
132nuclear envelope disassembly (GO:0051081)3.18278413
133regulation of spindle organization (GO:0090224)3.14200333
134positive regulation of cGMP metabolic process (GO:0030825)3.08903799
135mitotic recombination (GO:0006312)3.08605705
136positive regulation of bone remodeling (GO:0046852)3.08064481
137positive regulation of bone resorption (GO:0045780)3.08064481
138peptidyl-lysine dimethylation (GO:0018027)3.06264248
139protein maturation by protein folding (GO:0022417)3.05840028
140cranial nerve structural organization (GO:0021604)3.05299071
141mitotic metaphase plate congression (GO:0007080)3.03934916
142response to food (GO:0032094)3.01376860
143epithelial tube branching involved in lung morphogenesis (GO:0060441)3.01045384
144establishment of spindle localization (GO:0051293)3.00124168
145negative regulation of humoral immune response (GO:0002921)3.00027097
146regulation of heart morphogenesis (GO:2000826)2.97788916
147Leydig cell differentiation (GO:0033327)2.91373032
148generation of neurons (GO:0048699)2.91205769
149basement membrane organization (GO:0071711)2.91201870
150ribosome biogenesis (GO:0042254)2.90787844
151negative regulation of cell cycle G2/M phase transition (GO:1902750)2.89835740
152nucleus localization (GO:0051647)2.87359878
153tachykinin receptor signaling pathway (GO:0007217)2.86588007
154positive regulation of epidermis development (GO:0045684)2.86275605
155glycogen catabolic process (GO:0005980)2.85800140
156cilium or flagellum-dependent cell motility (GO:0001539)2.84371197
157negative regulation of fatty acid biosynthetic process (GO:0045717)2.84149088
158positive regulation of chromosome segregation (GO:0051984)2.82873889
159protein targeting to Golgi (GO:0000042)2.82695241
160phospholipid catabolic process (GO:0009395)2.82210431
161cranial nerve morphogenesis (GO:0021602)2.81454988
162neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.80947733
163regulation of translational fidelity (GO:0006450)2.80786996
164DNA geometric change (GO:0032392)2.80642313
165organ regeneration (GO:0031100)2.80618627
166cytoskeletal anchoring at plasma membrane (GO:0007016)2.79777875
167negative regulation of axon extension involved in axon guidance (GO:0048843)2.78812073
168N-glycan processing (GO:0006491)2.78519999
169eosinophil migration (GO:0072677)2.78499178
170mitotic cytokinesis (GO:0000281)2.78226146
171epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.77945991
172keratinocyte development (GO:0003334)2.77512115
173negative regulation of epidermal cell differentiation (GO:0045605)2.77382332
174tRNA methylation (GO:0030488)2.76991973
175protein export from nucleus (GO:0006611)2.76856289
176embryonic process involved in female pregnancy (GO:0060136)2.75626478
177substrate-dependent cell migration (GO:0006929)2.74768628
178negative regulation of epithelial cell migration (GO:0010633)2.73970330
179DNA duplex unwinding (GO:0032508)2.72822974
180outflow tract septum morphogenesis (GO:0003148)2.72350508
181positive regulation of DNA-dependent DNA replication (GO:2000105)2.70737825
182hormone biosynthetic process (GO:0042446)2.69583150
183sequestering of metal ion (GO:0051238)2.68272286
184positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.66965593
185bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65532161
186regulation of keratinocyte differentiation (GO:0045616)2.64998801
187positive regulation of growth hormone secretion (GO:0060124)2.64981773
188wound healing, spreading of cells (GO:0044319)2.64407007
189regulation of hair cycle (GO:0042634)2.63937592
190response to dexamethasone (GO:0071548)2.62597330
191progesterone metabolic process (GO:0042448)2.62122062
192glucan catabolic process (GO:0009251)2.61810877
193estrogen biosynthetic process (GO:0006703)11.8333710
194bone trabecula formation (GO:0060346)11.2114319
195detection of bacterium (GO:0016045)10.5559020
196activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)10.5193523
197mitotic sister chromatid cohesion (GO:0007064)10.2166281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.76474172
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.76422808
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.85381134
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.15162039
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.73355467
6ZNF263_19887448_ChIP-Seq_K562_Human3.45085022
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14167711
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.11707421
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90130917
10EZH2_22144423_ChIP-Seq_EOC_Human2.69194773
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66427225
12SCL_19346495_ChIP-Seq_HPC-7_Human2.63136390
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59971639
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.50647610
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40704185
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39694976
17FUS_26573619_Chip-Seq_HEK293_Human2.38319409
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35616865
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26166894
20EWS_26573619_Chip-Seq_HEK293_Human2.19040252
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18908412
22AR_21909140_ChIP-Seq_LNCAP_Human2.17835055
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16537240
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.14452941
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.14048236
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13943967
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.06906641
28E2F7_22180533_ChIP-Seq_HELA_Human10.9627192
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96132576
30HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.92387845
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.90512874
32XRN2_22483619_ChIP-Seq_HELA_Human1.90103685
33ELK1_19687146_ChIP-ChIP_HELA_Human1.88474922
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87625961
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86499028
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85976830
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85733296
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80466995
39* TTF2_22483619_ChIP-Seq_HELA_Human1.79045488
40DCP1A_22483619_ChIP-Seq_HELA_Human1.76609821
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73693755
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72099573
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.71355473
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69978066
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69910166
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68844018
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67297821
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.67126644
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65813593
50CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.64028393
51TP53_16413492_ChIP-PET_HCT116_Human1.63082460
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.61037772
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.60363878
54CLOCK_20551151_ChIP-Seq_293T_Human1.58272101
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53650629
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52831286
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52602739
58SMAD1_18555785_Chip-Seq_ESCs_Mouse1.51685055
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.49643473
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49594621
61CTCF_18555785_Chip-Seq_ESCs_Mouse1.49081691
62P300_18555785_Chip-Seq_ESCs_Mouse1.47662986
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47455742
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46177260
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45290970
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.41510069
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.39967753
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39609067
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.39138209
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39110041
71TFEB_21752829_ChIP-Seq_HELA_Human1.38748484
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37983796
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.35720513
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.35328208
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.35051546
76TAF15_26573619_Chip-Seq_HEK293_Human1.35018805
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34202940
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33860452
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.33067897
80ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31640650
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30750882
82GBX2_23144817_ChIP-Seq_PC3_Human1.30411592
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29693753
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29685613
85* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29631240
86KLF4_18555785_Chip-Seq_ESCs_Mouse1.29400715
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29390263
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28419274
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25925165
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.24784175
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24348501
92ZFX_18555785_Chip-Seq_ESCs_Mouse1.24027842
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22412752
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22088323
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21135383
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20656450
97GATA3_24758297_ChIP-Seq_MCF-7_Human1.19570464
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18678309
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17972495
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17809434
101E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17305504
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15737386
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15093560
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14988008
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14884077
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.12909324
107* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11289444
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.08791284
109* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08695418
110AHR_22903824_ChIP-Seq_MCF-7_Human1.08412751
111GATA1_26923725_Chip-Seq_HPCs_Mouse1.07553764
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07199377
113TP63_17297297_ChIP-ChIP_HaCaT_Human1.06912476
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06849224
115FOXP3_21729870_ChIP-Seq_TREG_Human1.06451524
116PU1_27457419_Chip-Seq_LIVER_Mouse1.05986845
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05450167
118CHD1_26751641_Chip-Seq_LNCaP_Human1.04940305
119* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03364409
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02224756
121KDM5A_27292631_Chip-Seq_BREAST_Human1.02160432
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01853192
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.01632434
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01553554
125* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01501880
126* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01489482
127P53_22387025_ChIP-Seq_ESCs_Mouse1.00613464
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00472222
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99526670
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98493677
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98360979
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98360979
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96785121
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96532941
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96357320
136* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96228473
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95717768
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95452649
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94443303
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93114358
141GABP_19822575_ChIP-Seq_HepG2_Human0.92511157
142* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91117179
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90792949
144ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90167563
145P300_19829295_ChIP-Seq_ESCs_Human0.88833730
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87626707
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87264414
148SMAD4_21799915_ChIP-Seq_A2780_Human0.86060367
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85737738
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85369521
151* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84278698
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83952570
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83863762
154STAT3_23295773_ChIP-Seq_U87_Human0.83738745
155* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83464060
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.81927666
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81752619
158CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81374387
159E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80977751
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.80185059
161CBP_21632823_ChIP-Seq_H3396_Human0.79225943
162* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79192885
163WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77784657
164SMAD_19615063_ChIP-ChIP_OVARY_Human0.76893805
165ZNF274_21170338_ChIP-Seq_K562_Hela0.75736920
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.75618004
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75521842
168FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74572927
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74079705
170POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73141873
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.72097951
172IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72024523
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.71609197
174RUNX2_22187159_ChIP-Seq_PCA_Human0.71433940
175SMAD3_21741376_ChIP-Seq_EPCs_Human0.71047381
176* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.70427555
177ER_23166858_ChIP-Seq_MCF-7_Human0.70169027
178REST_21632747_ChIP-Seq_MESCs_Mouse0.68214208
179CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.66986222
180TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.66952891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005187_abnormal_penis_morphology7.42647545
2MP0003315_abnormal_perineum_morphology7.27567553
3MP0009697_abnormal_copulation4.97372577
4MP0002009_preneoplasia4.27263348
5MP0001346_abnormal_lacrimal_gland3.21328639
6MP0010030_abnormal_orbit_morphology2.97877074
7MP0000647_abnormal_sebaceous_gland2.65663556
8MP0009672_abnormal_birth_weight2.64924785
9MP0009780_abnormal_chondrocyte_physiolo2.60553169
10MP0002163_abnormal_gland_morphology2.59608328
11MP0002098_abnormal_vibrissa_morphology2.31443093
12MP0001502_abnormal_circadian_rhythm2.23696590
13MP0004782_abnormal_surfactant_physiolog2.22799691
14MP0005023_abnormal_wound_healing2.19127353
15* MP0000631_abnormal_neuroendocrine_gland2.13063320
16MP0003693_abnormal_embryo_hatching2.12465081
17MP0003787_abnormal_imprinting2.12462667
18MP0010307_abnormal_tumor_latency2.08375822
19MP0009379_abnormal_foot_pigmentation2.06969049
20MP0004233_abnormal_muscle_weight1.97204120
21MP0010234_abnormal_vibrissa_follicle1.93904023
22MP0003448_altered_tumor_morphology1.92827573
23MP0010094_abnormal_chromosome_stability1.90896707
24MP0003300_gastrointestinal_ulcer1.90302130
25MP0003690_abnormal_glial_cell1.90169060
26MP0003705_abnormal_hypodermis_morpholog1.88596060
27MP0008789_abnormal_olfactory_epithelium1.87951854
28MP0001881_abnormal_mammary_gland1.85040234
29MP0009333_abnormal_splenocyte_physiolog1.84651319
30MP0005646_abnormal_pituitary_gland1.76901559
31MP0001299_abnormal_eye_distance/1.73918401
32MP0005623_abnormal_meninges_morphology1.72989355
33MP0008057_abnormal_DNA_replication1.71814086
34MP0005379_endocrine/exocrine_gland_phen1.69386356
35MP0003890_abnormal_embryonic-extraembry1.69361110
36MP0003718_maternal_effect1.68824822
37MP0004957_abnormal_blastocyst_morpholog1.63443432
38MP0003121_genomic_imprinting1.62117615
39MP0002638_abnormal_pupillary_reflex1.59045720
40MP0003567_abnormal_fetal_cardiomyocyte1.57090661
41MP0005551_abnormal_eye_electrophysiolog1.56345687
42MP0000627_abnormal_mammary_gland1.55929137
43MP0001188_hyperpigmentation1.55667273
44MP0001348_abnormal_lacrimal_gland1.54379371
45MP0002166_altered_tumor_susceptibility1.54106137
46MP0000569_abnormal_digit_pigmentation1.53764859
47MP0003566_abnormal_cell_adhesion1.53731340
48MP0001485_abnormal_pinna_reflex1.52901389
49MP0003123_paternal_imprinting1.52884458
50MP0004043_abnormal_pH_regulation1.48718789
51MP0005408_hypopigmentation1.47978302
52MP0003950_abnormal_plasma_membrane1.47956698
53MP0002909_abnormal_adrenal_gland1.47159908
54MP0002877_abnormal_melanocyte_morpholog1.42348674
55MP0003936_abnormal_reproductive_system1.40729823
56MP0005171_absent_coat_pigmentation1.40337771
57MP0000377_abnormal_hair_follicle1.38131522
58MP0002086_abnormal_extraembryonic_tissu1.37734147
59MP0005334_abnormal_fat_pad1.35365660
60MP0000358_abnormal_cell_content/1.33856890
61MP0003091_abnormal_cell_migration1.33705404
62MP0001727_abnormal_embryo_implantation1.33458992
63MP0008775_abnormal_heart_ventricle1.31582469
64MP0010352_gastrointestinal_tract_polyps1.31024095
65MP0006138_congestive_heart_failure1.25926755
66MP0008058_abnormal_DNA_repair1.21862827
67MP0000534_abnormal_ureter_morphology1.19416914
68MP0009703_decreased_birth_body1.18556060
69MP0001730_embryonic_growth_arrest1.18333439
70MP0002139_abnormal_hepatobiliary_system1.16570642
71MP0001661_extended_life_span1.14505367
72MP0000427_abnormal_hair_cycle1.13974233
73MP0002970_abnormal_white_adipose1.11695615
74MP0002006_tumorigenesis1.07048263
75MP0005389_reproductive_system_phenotype1.06300891
76MP0006082_CNS_inflammation1.05964800
77MP0005666_abnormal_adipose_tissue1.05890544
78MP0002127_abnormal_cardiovascular_syste1.05391847
79MP0002090_abnormal_vision1.04779181
80MP0002796_impaired_skin_barrier1.04290066
81MP0003111_abnormal_nucleus_morphology1.04090614
82MP0004147_increased_porphyrin_level1.03955111
83MP0005386_behavior/neurological_phenoty1.03501746
84MP0004924_abnormal_behavior1.03501746
85MP0003115_abnormal_respiratory_system1.02869834
86MP0003941_abnormal_skin_development1.02533772
87MP0005257_abnormal_intraocular_pressure1.02274945
88MP0002557_abnormal_social/conspecific_i1.01839893
89MP0000383_abnormal_hair_follicle1.01831035
90MP0000015_abnormal_ear_pigmentation1.00666606
91MP0001216_abnormal_epidermal_layer1.00608231
92MP0003938_abnormal_ear_development1.00477820
93MP0008569_lethality_at_weaning0.98562625
94MP0000013_abnormal_adipose_tissue0.97556312
95MP0002751_abnormal_autonomic_nervous0.96778127
96MP0006035_abnormal_mitochondrial_morpho0.96736304
97MP0003942_abnormal_urinary_system0.95191370
98* MP0000681_abnormal_thyroid_gland0.94381258
99MP0005197_abnormal_uvea_morphology0.93229323
100MP0002080_prenatal_lethality0.91841206
101MP0002697_abnormal_eye_size0.91751849
102MP0002234_abnormal_pharynx_morphology0.91503858
103MP0003045_fibrosis0.91149140
104MP0002269_muscular_atrophy0.90518065
105MP0000350_abnormal_cell_proliferation0.90196851
106MP0000372_irregular_coat_pigmentation0.89768389
107MP0000750_abnormal_muscle_regeneration0.89253802
108MP0008961_abnormal_basal_metabolism0.87020405
109MP0005647_abnormal_sex_gland0.86742268
110MP0006072_abnormal_retinal_apoptosis0.84598429
111MP0002177_abnormal_outer_ear0.83586501
112MP0003984_embryonic_growth_retardation0.83374923
113MP0004197_abnormal_fetal_growth/weight/0.83182965
114MP0003656_abnormal_erythrocyte_physiolo0.83151999
115MP0008877_abnormal_DNA_methylation0.82909975
116MP0004185_abnormal_adipocyte_glucose0.82031759
117MP0000467_abnormal_esophagus_morphology0.82011779
118MP0003077_abnormal_cell_cycle0.81862918
119MP0002088_abnormal_embryonic_growth/wei0.81064424
120MP0003959_abnormal_lean_body0.80969674
121MP0005409_darkened_coat_color0.79763367
122MP0003935_abnormal_craniofacial_develop0.79339955
123MP0006276_abnormal_autonomic_nervous0.79169408
124MP0002971_abnormal_brown_adipose0.76526767
125MP0005380_embryogenesis_phenotype0.76052308
126MP0001672_abnormal_embryogenesis/_devel0.76052308
127MP0005076_abnormal_cell_differentiation0.75886374
128MP0000639_abnormal_adrenal_gland0.74559184
129MP0004130_abnormal_muscle_cell0.73872730
130MP0002084_abnormal_developmental_patter0.73789805
131MP0002277_abnormal_respiratory_mucosa0.73175648
132MP0002396_abnormal_hematopoietic_system0.72751595
133MP0005375_adipose_tissue_phenotype0.72696955
134MP0001243_abnormal_dermal_layer0.72601065
135MP0001879_abnormal_lymphatic_vessel0.72355780
136MP0005319_abnormal_enzyme/_coenzyme0.71133825
137MP0010678_abnormal_skin_adnexa0.70640187
138MP0000371_diluted_coat_color0.70059915
139MP0000003_abnormal_adipose_tissue0.69585566
140MP0004808_abnormal_hematopoietic_stem0.69492812
141MP0003453_abnormal_keratinocyte_physiol0.68358822
142MP0004859_abnormal_synaptic_plasticity0.68310563
143* MP0002210_abnormal_sex_determination0.68225144
144MP0000751_myopathy0.68068880
145MP0002063_abnormal_learning/memory/cond0.67042512
146MP0008932_abnormal_embryonic_tissue0.65494105
147MP0001697_abnormal_embryo_size0.63902682
148MP0009115_abnormal_fat_cell0.62954012
149MP0000367_abnormal_coat/_hair0.62911242
150MP0000579_abnormal_nail_morphology0.62847262
151MP0003937_abnormal_limbs/digits/tail_de0.61819601
152MP0005384_cellular_phenotype0.61765528
153MP0003136_yellow_coat_color0.61207120
154MP0001440_abnormal_grooming_behavior0.61022078
155MP0002160_abnormal_reproductive_system0.60363918
156MP0003635_abnormal_synaptic_transmissio0.60358424
157MP0005621_abnormal_cell_physiology0.60313126
158MP0001963_abnormal_hearing_physiology0.59581418
159* MP0001145_abnormal_male_reproductive0.59492691
160MP0005501_abnormal_skin_physiology0.59061088
161MP0001919_abnormal_reproductive_system0.58662902
162MP0004084_abnormal_cardiac_muscle0.58441508
163MP0000490_abnormal_crypts_of0.58392435
164MP0004858_abnormal_nervous_system0.56112111
165MP0001915_intracranial_hemorrhage0.54642500

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.80154591
2Cervical subluxation (HP:0003308)6.52215134
3Volvulus (HP:0002580)6.28057510
4Ankle contracture (HP:0006466)6.21415788
5Macroorchidism (HP:0000053)5.64026817
6Aplasia cutis congenita (HP:0001057)5.59661382
7Oligodactyly (hands) (HP:0001180)5.33474900
8Vertebral compression fractures (HP:0002953)5.11549987
9Wrist flexion contracture (HP:0001239)5.04354583
10Protrusio acetabuli (HP:0003179)4.68804757
11Conjunctival telangiectasia (HP:0000524)4.42544238
12Hypochromic microcytic anemia (HP:0004840)4.35650042
13Sparse lateral eyebrow (HP:0005338)4.25818556
14Hypogonadotrophic hypogonadism (HP:0000044)4.16176874
15Cerebellar dysplasia (HP:0007033)4.12877235
16Broad metatarsal (HP:0001783)4.12164629
17Ankyloglossia (HP:0010296)4.08184583
18Oligodactyly (HP:0012165)4.04173957
19Subcapsular cataract (HP:0000523)3.89535236
20Impulsivity (HP:0100710)3.89170002
21Increased nuchal translucency (HP:0010880)3.74675881
22Papilledema (HP:0001085)3.74489156
23Heterotopia (HP:0002282)3.72336520
24Hypergonadotropic hypogonadism (HP:0000815)3.66078310
25Truncal obesity (HP:0001956)3.56590921
26Delayed closure of the anterior fontanelle (HP:0001476)3.51821816
27Hyperglycinemia (HP:0002154)3.45856159
28Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.44185322
29Obsessive-compulsive behavior (HP:0000722)3.43554305
30Deep philtrum (HP:0002002)3.38012151
31Abnormality of the vasculature of the conjunctiva (HP:0008054)3.36420188
32Abnormality of the parietal bone (HP:0002696)3.28036799
33Lymphangioma (HP:0100764)3.26576525
34Woolly hair (HP:0002224)3.18951952
35Sensory axonal neuropathy (HP:0003390)3.12676027
36Skin nodule (HP:0200036)3.11068566
37Inappropriate behavior (HP:0000719)3.10799602
38Testicular neoplasm (HP:0010788)3.08837078
39Increased number of teeth (HP:0011069)3.06269704
40Primary amenorrhea (HP:0000786)3.05545344
41Periauricular skin pits (HP:0100277)3.01865885
42Preauricular pit (HP:0004467)3.01865885
43Abnormality of oral frenula (HP:0000190)3.00520984
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98513759
45Aplastic anemia (HP:0001915)2.96825439
46Decreased testicular size (HP:0008734)2.96648602
47Amelogenesis imperfecta (HP:0000705)2.93620339
48Microvesicular hepatic steatosis (HP:0001414)2.87306183
49Astrocytoma (HP:0009592)2.86267680
50Abnormality of the astrocytes (HP:0100707)2.86267680
51Hemorrhage of the eye (HP:0011885)2.84832862
52Hyperthyroidism (HP:0000836)2.83335908
53Alkalosis (HP:0001948)2.77482944
54Widely patent fontanelles and sutures (HP:0004492)2.73910005
55Pigmentary retinal degeneration (HP:0001146)2.72937429
56Abnormality of chromosome segregation (HP:0002916)2.72799671
57Birth length less than 3rd percentile (HP:0003561)2.71798202
58Agitation (HP:0000713)2.70644320
59Delayed cranial suture closure (HP:0000270)2.69607181
60Short clavicles (HP:0000894)2.68679153
61Hip contracture (HP:0003273)2.67397428
62Abnormality of chromosome stability (HP:0003220)2.65769476
63Hypercortisolism (HP:0001578)2.65570293
64Right ventricular cardiomyopathy (HP:0011663)2.64362620
65Abnormality of the renal collecting system (HP:0004742)2.62629006
66Tapered finger (HP:0001182)2.60763970
67Tarsal synostosis (HP:0008368)2.58374828
68Hypopigmentation of the fundus (HP:0007894)2.55869665
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55828129
70Cupped ear (HP:0000378)2.55496257
71X-linked recessive inheritance (HP:0001419)2.52999609
72Colon cancer (HP:0003003)2.52688848
73Rectal prolapse (HP:0002035)2.51744928
74Fragile nails (HP:0001808)2.50119229
75Cutaneous melanoma (HP:0012056)2.49823832
76Truncal ataxia (HP:0002078)2.47881999
77Ependymoma (HP:0002888)2.46066361
78Split foot (HP:0001839)2.44527359
79Protruding tongue (HP:0010808)2.44026733
80Progressive muscle weakness (HP:0003323)2.42833685
81Menstrual irregularities (HP:0000858)2.41326705
82Aplasia/Hypoplasia of the clavicles (HP:0006710)2.40390246
83Asymmetry of the thorax (HP:0001555)2.40095532
84Coronal craniosynostosis (HP:0004440)2.39977109
85Skin pits (HP:0100276)2.39747707
86Abnormality of the 4th metacarpal (HP:0010012)2.38303835
87Sacral dimple (HP:0000960)2.37894232
88Female pseudohermaphroditism (HP:0010458)2.35792407
89Congenital ichthyosiform erythroderma (HP:0007431)2.35595570
90Cerebral edema (HP:0002181)2.33636396
91Posterior subcapsular cataract (HP:0007787)2.30856121
92Absent frontal sinuses (HP:0002688)2.30192123
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29685710
94Disinhibition (HP:0000734)2.22845373
95Atresia of the external auditory canal (HP:0000413)2.21707251
96Synostosis involving bones of the feet (HP:0009140)2.21015679
97Synostosis involving bones of the lower limbs (HP:0009138)2.21015679
98Submucous cleft hard palate (HP:0000176)2.19951246
99Hypoparathyroidism (HP:0000829)2.18597842
100Hyperglycinuria (HP:0003108)2.18495363
101Action tremor (HP:0002345)2.16634171
102Intellectual disability, mild (HP:0001256)2.16446823
103Abnormal sex determination (HP:0012244)2.16354753
104Sex reversal (HP:0012245)2.16354753
105Glioma (HP:0009733)2.15762889
106Short chin (HP:0000331)2.14841144
107Split hand (HP:0001171)2.14059303
108Abnormal social behavior (HP:0012433)2.11419750
109Impaired social interactions (HP:0000735)2.11419750
110Short 4th metacarpal (HP:0010044)2.09137735
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09137735
112Underdeveloped supraorbital ridges (HP:0009891)2.08866225
113Abnormality of permanent molar morphology (HP:0011071)2.06146137
114Abnormality of the dental root (HP:0006486)2.06146137
115Taurodontia (HP:0000679)2.06146137
116Hypophosphatemic rickets (HP:0004912)2.06062073
117Abnormality of dental color (HP:0011073)2.05146045
118Narrow nasal bridge (HP:0000446)2.02588983
119Abnormality of the preputium (HP:0100587)2.01331167
120Natal tooth (HP:0000695)2.00218570
121Overriding aorta (HP:0002623)1.99256509
122Abnormality of cochlea (HP:0000375)1.98680086
123Hyperammonemia (HP:0001987)1.98269493
124Abnormality of the frontal sinuses (HP:0002687)1.97538993
125Ureteral duplication (HP:0000073)1.97191867
126Abnormality of pyrimidine metabolism (HP:0004353)1.96656737
127Aortic aneurysm (HP:0004942)1.96615257
128Depression (HP:0000716)1.95495311
129Impaired pain sensation (HP:0007328)1.95449701
130Abnormality of pain sensation (HP:0010832)1.95449701
131Osteomalacia (HP:0002749)1.95345808
132Wide cranial sutures (HP:0010537)1.93052999
133Ovarian neoplasm (HP:0100615)1.92341778
134Chromsome breakage (HP:0040012)1.91251271
135Deviation of the thumb (HP:0009603)1.88848219
136Excessive salivation (HP:0003781)1.88096356
137Drooling (HP:0002307)1.88096356
138Hyperacusis (HP:0010780)1.87416376
139Duplicated collecting system (HP:0000081)1.87343775
140Attention deficit hyperactivity disorder (HP:0007018)1.87082585
141Stroke (HP:0001297)1.86777766
142Achilles tendon contracture (HP:0001771)1.86267123
143Resting tremor (HP:0002322)1.85575933
144Bilateral sensorineural hearing impairment (HP:0008619)1.85452023
145Areflexia of lower limbs (HP:0002522)1.84788257
146Broad-based gait (HP:0002136)1.83543691
147Cafe-au-lait spot (HP:0000957)1.83372659
148Abnormality of ocular smooth pursuit (HP:0000617)1.83246456
149Hyperventilation (HP:0002883)1.82960681
150Absent hand (HP:0004050)1.82711860
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82379480
152Hyporeflexia of lower limbs (HP:0002600)1.82300061
153Hematochezia (HP:0002573)1.81905268
154Breast hypoplasia (HP:0003187)1.81779225
155Termporal pattern (HP:0011008)1.81711839
156Insidious onset (HP:0003587)1.81711839
157Tented upper lip vermilion (HP:0010804)1.81548502
158Fair hair (HP:0002286)1.80859604
159Abnormality of molar (HP:0011077)1.80340502
160Abnormality of molar morphology (HP:0011070)1.80340502
161Polar cataract (HP:0010696)1.79720194
162Pheochromocytoma (HP:0002666)1.79544812
163Poor eye contact (HP:0000817)1.79009890
164Dysmetric saccades (HP:0000641)1.78857863
165Squamous cell carcinoma (HP:0002860)1.78846981
166Secondary amenorrhea (HP:0000869)1.78419702
167Abnormal auditory evoked potentials (HP:0006958)1.78325979
168Overlapping toe (HP:0001845)1.78181284
169Abnormality of the acetabulum (HP:0003170)1.78154657
170Septate vagina (HP:0001153)1.76697380
171Renovascular hypertension (HP:0100817)1.76164264
172Hypoplasia of the maxilla (HP:0000327)1.75314511
173Pointed chin (HP:0000307)1.74944239
174Curly hair (HP:0002212)1.74474130
175Megalocornea (HP:0000485)1.73954863
176Abnormality of glycolysis (HP:0004366)1.73077820
177Increased serum pyruvate (HP:0003542)1.73077820
178Thyroid-stimulating hormone excess (HP:0002925)1.71916232
179Large earlobe (HP:0009748)1.71843852
180Nonimmune hydrops fetalis (HP:0001790)1.71695382
181Premature ovarian failure (HP:0008209)1.71693147
182Short palpebral fissure (HP:0012745)1.71300875
183Neonatal short-limb short stature (HP:0008921)1.71199352
184Abnormality of the dental pulp (HP:0006479)1.71112099
185Mucosal telangiectasiae (HP:0100579)1.70773583
186Aplasia/Hypoplasia of the nipples (HP:0006709)1.70117639
187Metatarsus adductus (HP:0001840)1.67737323
188Capillary hemangiomas (HP:0005306)1.67447999
189Testicular atrophy (HP:0000029)1.62550238
190Back pain (HP:0003418)1.62048255
191Abnormality of serum amino acid levels (HP:0003112)1.61042699
192Micronodular cirrhosis (HP:0001413)1.60715725
193Camptodactyly of toe (HP:0001836)1.60349552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.98199900
2PDK24.55238383
3MELK4.25975761
4YES13.83306975
5PBK3.73798853
6TRPM73.65771089
7ACVR1B3.51425507
8ICK3.39308244
9CDK63.23844455
10CDC73.17519806
11SCYL23.02206600
12CDK123.00873782
13MAP3K22.91369558
14NME12.85425202
15MST1R2.69224334
16MKNK12.66561670
17UHMK12.62954356
18DYRK1B2.62497346
19EIF2AK32.47391300
20GRK52.46690623
21MST42.44959743
22EIF2AK12.42540074
23NEK12.37383472
24FGFR22.37145003
25BRSK12.18365863
26KDR2.14668314
27RPS6KB22.11355126
28NME22.10506307
29MAPKAPK51.99457356
30TSSK61.96930816
31CDK41.85490203
32KSR21.83350173
33TRIB31.75783160
34NEK21.70298986
35BRSK21.69421179
36AURKB1.67972549
37TTK1.64933581
38BCR1.63694706
39BRD41.58692397
40GSK3A1.55523428
41PASK1.54792477
42ERBB31.54727200
43FGFR31.50780443
44NTRK31.49240524
45BMPR21.49072280
46WNK31.41302413
47EPHA21.39862619
48NEK61.37987803
49KSR11.36675627
50HIPK21.35725527
51RIPK41.35485165
52PKN21.33263803
53MAP3K91.32053520
54RIPK11.29553262
55SMG11.28845688
56FRK1.27244684
57CDC42BPA1.26608889
58RET1.22504687
59MET1.16388585
60ERBB41.11696646
61EEF2K1.10365159
62PIM11.03461949
63NEK91.03087557
64MAP3K71.00765549
65LATS21.00344094
66PLK30.99608692
67PNCK0.96458268
68IRAK30.93573520
69BMPR1B0.91416256
70PRKCI0.89818285
71CAMK1G0.86243478
72ATR0.84091106
73MINK10.83689844
74STK100.83437353
75MAP2K40.82172578
76ATM0.80784068
77CHEK20.79353047
78CAMKK20.78205697
79PLK10.72179039
80FGFR10.71724133
81BRAF0.71309172
82STK30.70420654
83CHEK10.68814641
84CDK10.67782760
85CDK80.66595972
86PAK30.65972626
87PAK60.64193560
88PDPK10.63000949
89FGFR40.61147894
90CDK20.60621881
91MTOR0.57983588
92CDK90.57952603
93SRPK10.57535151
94BUB10.57001311
95STK160.55316543
96PRKAA20.54481130
97CCNB10.53169075
98NTRK20.53120157
99MAP2K10.52985560
100WEE10.52444608
101JAK20.51786859
102FER0.47391102
103PTK20.47388122
104MAP3K140.46947579
105CDK70.45499177
106MAPK100.43852589
107ALK0.41834843
108TYRO30.41385107
109CDK140.40866036
110SGK10.40498295
111TGFBR10.40052793
112PRKDC0.39963900
113STK110.39955466
114PDGFRB0.39749660
115PDGFRA0.39582780
116DYRK1A0.38945744
117CSNK1D0.38789220
118MAP3K40.38363785
119MAPK110.37459271
120AURKA0.37227636
121MAPK10.37175824
122DYRK30.37000495
123RPS6KB10.36475467
124MAPK140.36108160
125CSK0.36034048
126MARK10.35778907
127PLK20.35706738
128RAF10.34240669
129WNK10.33948541
130STK390.33888470
131CDK50.33425919
132MAP2K30.33167558
133MAPK120.32482976
134ABL20.32184824
135GSK3B0.31606908
136CDK190.31207437
137MAP3K80.30424878
138FGR0.29584878
139PAK40.29078985
140CAMK1D0.28643818
141MAPK40.28455320
142SRC0.28204391
143PRKAA10.28080013
144OXSR10.27946071
145AKT20.27300221
146IGF1R0.26014797
147WNK40.25871171
148PLK40.25683939
149TESK10.25401256
150PDK10.24943838
151AKT10.24497507
152CDK180.24304572
153RPS6KA10.24251035
154CSNK1E0.23913970
155CSNK2A20.22709955
156LRRK20.22130770
157MARK30.21249446
158PRKACB0.17876021

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.76594410
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.34820009
3* GnRH signaling pathway_Homo sapiens_hsa049123.18847967
4Type II diabetes mellitus_Homo sapiens_hsa049303.14369767
5Linoleic acid metabolism_Homo sapiens_hsa005913.06115286
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01512615
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98369618
8Folate biosynthesis_Homo sapiens_hsa007902.73220118
9* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.58298407
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.55704289
11RNA transport_Homo sapiens_hsa030132.45758887
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34404936
13Adipocytokine signaling pathway_Homo sapiens_hsa049202.31358383
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.25254821
15Ether lipid metabolism_Homo sapiens_hsa005652.20748749
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.19059376
17Dorso-ventral axis formation_Homo sapiens_hsa043202.15121101
18Cell cycle_Homo sapiens_hsa041102.10114246
19Longevity regulating pathway - mammal_Homo sapiens_hsa042112.07759552
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98661526
21VEGF signaling pathway_Homo sapiens_hsa043701.95541270
22* Ovarian steroidogenesis_Homo sapiens_hsa049131.91337733
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88155172
24Spliceosome_Homo sapiens_hsa030401.84121165
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.82901059
26FoxO signaling pathway_Homo sapiens_hsa040681.82101079
27Selenocompound metabolism_Homo sapiens_hsa004501.80613706
28Mismatch repair_Homo sapiens_hsa034301.78631819
29Bladder cancer_Homo sapiens_hsa052191.78269814
30Protein export_Homo sapiens_hsa030601.77397648
31Biosynthesis of amino acids_Homo sapiens_hsa012301.73396286
32Long-term depression_Homo sapiens_hsa047301.70051766
33DNA replication_Homo sapiens_hsa030301.69435103
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62878206
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55333175
36Nitrogen metabolism_Homo sapiens_hsa009101.47359270
37Circadian entrainment_Homo sapiens_hsa047131.45709258
38Proteasome_Homo sapiens_hsa030501.45206660
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.43771027
40Basal transcription factors_Homo sapiens_hsa030221.41965134
41Serotonergic synapse_Homo sapiens_hsa047261.40804795
42Oocyte meiosis_Homo sapiens_hsa041141.38761184
43AMPK signaling pathway_Homo sapiens_hsa041521.36971110
44Non-homologous end-joining_Homo sapiens_hsa034501.34501831
45Fatty acid biosynthesis_Homo sapiens_hsa000611.34198795
46Carbon metabolism_Homo sapiens_hsa012001.31984001
47Pyruvate metabolism_Homo sapiens_hsa006201.26382464
48Colorectal cancer_Homo sapiens_hsa052101.26069057
49Fatty acid metabolism_Homo sapiens_hsa012121.25565198
50Insulin signaling pathway_Homo sapiens_hsa049101.22363273
51Choline metabolism in cancer_Homo sapiens_hsa052311.19658759
52mRNA surveillance pathway_Homo sapiens_hsa030151.19586893
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19327472
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16640026
55Glutamatergic synapse_Homo sapiens_hsa047241.15713053
56Circadian rhythm_Homo sapiens_hsa047101.07085483
57Ribosome_Homo sapiens_hsa030101.06975818
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05234152
59Pathways in cancer_Homo sapiens_hsa052001.05104587
60Homologous recombination_Homo sapiens_hsa034401.02293821
61Thyroid cancer_Homo sapiens_hsa052161.01055499
62mTOR signaling pathway_Homo sapiens_hsa041501.00193377
63Rap1 signaling pathway_Homo sapiens_hsa040150.97671993
64Pancreatic cancer_Homo sapiens_hsa052120.96103109
65MicroRNAs in cancer_Homo sapiens_hsa052060.95129558
66Lysine degradation_Homo sapiens_hsa003100.93616977
67Chronic myeloid leukemia_Homo sapiens_hsa052200.92876929
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92564635
69Pyrimidine metabolism_Homo sapiens_hsa002400.92455052
70Butanoate metabolism_Homo sapiens_hsa006500.91156972
71Adherens junction_Homo sapiens_hsa045200.90697472
72Fanconi anemia pathway_Homo sapiens_hsa034600.89887807
73p53 signaling pathway_Homo sapiens_hsa041150.89763175
74Dopaminergic synapse_Homo sapiens_hsa047280.88508751
75Arginine and proline metabolism_Homo sapiens_hsa003300.87916793
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85743464
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83660354
78RNA polymerase_Homo sapiens_hsa030200.82347857
79RNA degradation_Homo sapiens_hsa030180.79217436
80Oxytocin signaling pathway_Homo sapiens_hsa049210.78721527
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78533323
82Fatty acid degradation_Homo sapiens_hsa000710.77937002
83Long-term potentiation_Homo sapiens_hsa047200.77194801
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76556519
85Galactose metabolism_Homo sapiens_hsa000520.74852948
86PPAR signaling pathway_Homo sapiens_hsa033200.73103700
87Hepatitis B_Homo sapiens_hsa051610.72930717
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71417091
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68947056
90Viral carcinogenesis_Homo sapiens_hsa052030.68217224
91Vitamin digestion and absorption_Homo sapiens_hsa049770.67546988
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.66635927
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63547984
94Propanoate metabolism_Homo sapiens_hsa006400.63409103
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62991302
96Cholinergic synapse_Homo sapiens_hsa047250.59599998
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.59546323
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.59510727
99Antigen processing and presentation_Homo sapiens_hsa046120.59045710
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58808102
101Prostate cancer_Homo sapiens_hsa052150.58708282
102Focal adhesion_Homo sapiens_hsa045100.58676544
103Mineral absorption_Homo sapiens_hsa049780.58040300
104Non-small cell lung cancer_Homo sapiens_hsa052230.58023506
105Small cell lung cancer_Homo sapiens_hsa052220.57779986
106ErbB signaling pathway_Homo sapiens_hsa040120.57040586
107Platelet activation_Homo sapiens_hsa046110.56382332
108Steroid biosynthesis_Homo sapiens_hsa001000.55964502
109Glioma_Homo sapiens_hsa052140.54963255
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54479759
111One carbon pool by folate_Homo sapiens_hsa006700.54316150
112Purine metabolism_Homo sapiens_hsa002300.54085671
113Sphingolipid metabolism_Homo sapiens_hsa006000.53689399
114MAPK signaling pathway_Homo sapiens_hsa040100.53636114
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51933497
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51917419
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51228542
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.50554643
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50345285
120Morphine addiction_Homo sapiens_hsa050320.48989600
121Fructose and mannose metabolism_Homo sapiens_hsa000510.48125267
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47346978
123Metabolic pathways_Homo sapiens_hsa011000.46868691
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.46429394
125GABAergic synapse_Homo sapiens_hsa047270.46249635
126* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45501959
127Glucagon signaling pathway_Homo sapiens_hsa049220.44796672
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43653011
129Regulation of autophagy_Homo sapiens_hsa041400.43610260
130* Thyroid hormone synthesis_Homo sapiens_hsa049180.43443748
131N-Glycan biosynthesis_Homo sapiens_hsa005100.43271969
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43099294
133Measles_Homo sapiens_hsa051620.42406264
134Ras signaling pathway_Homo sapiens_hsa040140.42232982
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40876149
136HTLV-I infection_Homo sapiens_hsa051660.40802397
137TGF-beta signaling pathway_Homo sapiens_hsa043500.39782966
138Inositol phosphate metabolism_Homo sapiens_hsa005620.39573659
139Endometrial cancer_Homo sapiens_hsa052130.39432392
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38897824
141Arachidonic acid metabolism_Homo sapiens_hsa005900.37833898
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37026394
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35949473
144HIF-1 signaling pathway_Homo sapiens_hsa040660.35137320
145Amphetamine addiction_Homo sapiens_hsa050310.34397536
146Insulin resistance_Homo sapiens_hsa049310.34078267
147Base excision repair_Homo sapiens_hsa034100.33588830
148Basal cell carcinoma_Homo sapiens_hsa052170.33501974
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33098596
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32872803
151Pentose phosphate pathway_Homo sapiens_hsa000300.32784599
152Nucleotide excision repair_Homo sapiens_hsa034200.31881949
153Huntingtons disease_Homo sapiens_hsa050160.31534079
154Hedgehog signaling pathway_Homo sapiens_hsa043400.31294960
155Proteoglycans in cancer_Homo sapiens_hsa052050.31240813
156Nicotine addiction_Homo sapiens_hsa050330.30289918
157Chemokine signaling pathway_Homo sapiens_hsa040620.30237772
158Hippo signaling pathway_Homo sapiens_hsa043900.30206780
159Arginine biosynthesis_Homo sapiens_hsa002200.28776541
160Estrogen signaling pathway_Homo sapiens_hsa049150.28383858
161Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28154384
162Legionellosis_Homo sapiens_hsa051340.27812037
163Sulfur relay system_Homo sapiens_hsa041220.27426999
164Fatty acid elongation_Homo sapiens_hsa000620.26428304

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