CGB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)9.54398808
2thyroid hormone metabolic process (GO:0042403)7.41314793
3estrogen biosynthetic process (GO:0006703)7.17759147
4endothelial cell proliferation (GO:0001935)7.06726462
5negative regulation of blood vessel endothelial cell migration (GO:0043537)6.42266991
6positive regulation of hair follicle development (GO:0051798)6.09669263
7positive regulation of hair cycle (GO:0042635)6.09669263
8sprouting angiogenesis (GO:0002040)6.03409196
9thyroid gland development (GO:0030878)6.01613670
10negative regulation of organ growth (GO:0046621)5.92732334
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.79996082
12vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.72169379
13protein retention in ER lumen (GO:0006621)5.67600462
14positive regulation of blood vessel endothelial cell migration (GO:0043536)5.48461887
15blood vessel maturation (GO:0001955)5.43488066
16regulation of gonadotropin secretion (GO:0032276)5.22042200
17DNA replication initiation (GO:0006270)5.16012003
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.14091342
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)5.08959724
20regulation of mitotic spindle organization (GO:0060236)4.78182386
21mitotic metaphase plate congression (GO:0007080)4.65452331
22trabecula formation (GO:0060343)4.65337464
23peptide hormone processing (GO:0016486)4.29359337
24wound healing, spreading of epidermal cells (GO:0035313)4.28675647
25tooth mineralization (GO:0034505)4.24690611
26regulation of spindle organization (GO:0090224)4.14558108
27cranial suture morphogenesis (GO:0060363)4.13208979
28negative regulation of activin receptor signaling pathway (GO:0032926)4.07116895
29female pregnancy (GO:0007565)4.02073367
30negative regulation of endothelial cell migration (GO:0010596)4.01652729
31regulation of hair follicle development (GO:0051797)4.01463456
32cytoskeletal anchoring at plasma membrane (GO:0007016)4.00947002
33syncytium formation (GO:0006949)3.99217879
34nuclear pore complex assembly (GO:0051292)3.98486090
35negative regulation of epidermal cell differentiation (GO:0045605)3.96253036
36response to insecticide (GO:0017085)3.86700594
37C21-steroid hormone biosynthetic process (GO:0006700)3.84542150
38citrulline biosynthetic process (GO:0019240)3.84281890
39response to follicle-stimulating hormone (GO:0032354)3.80862413
40positive regulation of growth hormone secretion (GO:0060124)3.80416847
41mitotic chromosome condensation (GO:0007076)3.79001927
42desmosome organization (GO:0002934)3.76582241
43COPI coating of Golgi vesicle (GO:0048205)3.72369102
44Golgi transport vesicle coating (GO:0048200)3.72369102
45regulation of histone phosphorylation (GO:0033127)3.66669239
46nuclear pore organization (GO:0006999)3.66434850
47organ regeneration (GO:0031100)3.64168496
48epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.59224651
49positive regulation of epidermis development (GO:0045684)3.52789811
50protein maturation by protein folding (GO:0022417)3.48258654
51metaphase plate congression (GO:0051310)3.45077295
52DNA unwinding involved in DNA replication (GO:0006268)3.43283577
53keratinocyte development (GO:0003334)3.38004960
54trophoblast giant cell differentiation (GO:0060707)3.37297107
55wound healing, spreading of cells (GO:0044319)3.35924536
56ER overload response (GO:0006983)3.34560914
57activation of Rac GTPase activity (GO:0032863)3.34290626
58regulation of DNA endoreduplication (GO:0032875)3.23369791
59positive regulation of chromosome segregation (GO:0051984)3.22120654
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21778040
61outflow tract septum morphogenesis (GO:0003148)3.18408077
62placenta development (GO:0001890)3.17471284
63craniofacial suture morphogenesis (GO:0097094)3.12576653
64peptidyl-arginine modification (GO:0018195)3.08088497
65ventricular cardiac muscle cell development (GO:0055015)3.05735663
66L-alpha-amino acid transmembrane transport (GO:1902475)3.05331242
67cell differentiation involved in embryonic placenta development (GO:0060706)3.01089240
68mitotic sister chromatid segregation (GO:0000070)3.00294129
69negative regulation of epidermis development (GO:0045683)2.99249846
70vitamin transmembrane transport (GO:0035461)2.97874938
71pore complex assembly (GO:0046931)2.95349756
72regulation of growth hormone secretion (GO:0060123)2.94241605
73androgen biosynthetic process (GO:0006702)2.92974113
74negative regulation of epithelial cell migration (GO:0010633)2.89182323
75regulation of hippo signaling (GO:0035330)2.85836501
76mitotic nuclear envelope disassembly (GO:0007077)2.84502128
77pre-miRNA processing (GO:0031054)2.83478288
78positive regulation of meiotic cell cycle (GO:0051446)2.80324004
79hippo signaling (GO:0035329)2.78954429
80cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.78212617
81regulation of blood vessel endothelial cell migration (GO:0043535)2.73799749
82notochord development (GO:0030903)2.73363351
83endodermal cell differentiation (GO:0035987)2.72520144
84sister chromatid segregation (GO:0000819)2.72504895
85multi-multicellular organism process (GO:0044706)2.72328477
86regulation of keratinocyte differentiation (GO:0045616)2.71748935
87positive regulation of DNA-dependent DNA replication (GO:2000105)2.70736761
88regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.70455352
89regulation of morphogenesis of a branching structure (GO:0060688)2.68956117
90female genitalia development (GO:0030540)2.64977956
91regulation of hair cycle (GO:0042634)2.64751112
92nuclear envelope disassembly (GO:0051081)2.64414242
93membrane disassembly (GO:0030397)2.64414242
94positive regulation of endothelial cell migration (GO:0010595)2.62675584
95sequestering of metal ion (GO:0051238)2.58575090
96glycerol ether metabolic process (GO:0006662)2.58493488
97androgen receptor signaling pathway (GO:0030521)2.57434988
98activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)12.2151248
99bone trabecula formation (GO:0060346)12.2037539
100endocrine hormone secretion (GO:0060986)12.0111561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.23630575
2E2F7_22180533_ChIP-Seq_HELA_Human5.15939761
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.08814051
4ZNF263_19887448_ChIP-Seq_K562_Human3.49259899
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01076412
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.86687396
7AR_21909140_ChIP-Seq_LNCAP_Human2.75698404
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60657131
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.60568293
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.59148166
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44897365
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32527858
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09966976
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99438205
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98085463
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95735581
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91241291
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89957154
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87051676
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79586633
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76104356
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75819836
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71625474
24HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.65772365
25TTF2_22483619_ChIP-Seq_HELA_Human1.62417543
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60650032
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.59809855
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59228143
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59141401
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.57404093
31TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55528656
32CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.55093453
33RACK7_27058665_Chip-Seq_MCF-7_Human1.54209800
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54092578
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53278178
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52042360
37SCL_19346495_ChIP-Seq_HPC-7_Human1.49848857
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49176527
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49145801
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48983116
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47187096
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46746254
43TP53_22127205_ChIP-Seq_IMR90_Human1.46365929
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44803656
45DCP1A_22483619_ChIP-Seq_HELA_Human1.44721079
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44133638
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43488133
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42611609
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39936994
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39308777
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38768922
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38431699
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36557273
54XRN2_22483619_ChIP-Seq_HELA_Human1.35885431
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34411093
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.30341724
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30110805
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26948698
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24516300
60LXR_22292898_ChIP-Seq_THP-1_Human1.23265110
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.21493810
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21445457
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21349960
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.19416398
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19218429
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.18197091
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17794578
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17375720
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13782696
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13481047
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11934714
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11736899
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11736899
74CLOCK_20551151_ChIP-Seq_293T_Human1.11610583
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11160694
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.09357314
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.08405403
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.08247297
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06791062
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.04731304
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04510447
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01867537
83* ATF3_27146783_Chip-Seq_COLON_Human1.01093142
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00615679
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99112315
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99056496
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99026592
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97825431
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97225283
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.95795833
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.94723587
92KDM5A_27292631_Chip-Seq_BREAST_Human0.93459477
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.92506961
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92479488
95NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92061302
96KDM2B_26808549_Chip-Seq_K562_Human0.91946557
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88319525
98TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86915564
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86705587
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.86652856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology7.35622662
2MP0000003_abnormal_adipose_tissue6.25296081
3MP0010307_abnormal_tumor_latency3.57373063
4MP0000013_abnormal_adipose_tissue3.25301550
5MP0005023_abnormal_wound_healing3.22465993
6MP0002163_abnormal_gland_morphology3.14940566
7MP0005375_adipose_tissue_phenotype3.04594801
8MP0009697_abnormal_copulation2.78297813
9MP0000647_abnormal_sebaceous_gland2.77173948
10MP0010094_abnormal_chromosome_stability2.57083931
11MP0000681_abnormal_thyroid_gland2.51158032
12MP0005076_abnormal_cell_differentiation2.38198334
13MP0005257_abnormal_intraocular_pressure2.27237375
14MP0009672_abnormal_birth_weight2.26094250
15MP0010234_abnormal_vibrissa_follicle2.22286649
16MP0002160_abnormal_reproductive_system2.18954122
17MP0003705_abnormal_hypodermis_morpholog2.10737094
18MP0003693_abnormal_embryo_hatching2.09792479
19MP0001348_abnormal_lacrimal_gland2.06054905
20MP0009115_abnormal_fat_cell2.03658142
21MP0005379_endocrine/exocrine_gland_phen2.02274532
22MP0002098_abnormal_vibrissa_morphology2.00285852
23MP0003448_altered_tumor_morphology1.95795525
24MP0010352_gastrointestinal_tract_polyps1.94107971
25MP0004782_abnormal_surfactant_physiolog1.90907414
26MP0004185_abnormal_adipocyte_glucose1.89857392
27MP0003566_abnormal_cell_adhesion1.80356739
28MP0004957_abnormal_blastocyst_morpholog1.66583603
29MP0002796_impaired_skin_barrier1.63022981
30MP0001881_abnormal_mammary_gland1.62417245
31MP0000627_abnormal_mammary_gland1.59880586
32MP0008004_abnormal_stomach_pH1.57833679
33MP0002138_abnormal_hepatobiliary_system1.53957840
34MP0003453_abnormal_keratinocyte_physiol1.53686349
35MP0002909_abnormal_adrenal_gland1.50110008
36MP0000537_abnormal_urethra_morphology1.45938573
37MP0000613_abnormal_salivary_gland1.40175679
38MP0002086_abnormal_extraembryonic_tissu1.39666965
39MP0001661_extended_life_span1.36245932
40MP0009333_abnormal_splenocyte_physiolog1.36011470
41MP0000377_abnormal_hair_follicle1.35760654
42MP0005389_reproductive_system_phenotype1.30636202
43MP0003718_maternal_effect1.30074354
44MP0003077_abnormal_cell_cycle1.29893379
45MP0001730_embryonic_growth_arrest1.29463197
46MP0003936_abnormal_reproductive_system1.27516278
47MP0003111_abnormal_nucleus_morphology1.26643874
48MP0009703_decreased_birth_body1.26170847
49MP0001216_abnormal_epidermal_layer1.25040939
50MP0001697_abnormal_embryo_size1.19190615
51MP0001849_ear_inflammation1.16508142
52MP0002127_abnormal_cardiovascular_syste1.16084992
53MP0000631_abnormal_neuroendocrine_gland1.15938664
54MP0005501_abnormal_skin_physiology1.14505922
55MP0000350_abnormal_cell_proliferation1.14153139
56MP0003950_abnormal_plasma_membrane1.12528959
57MP0000358_abnormal_cell_content/1.11936156
58MP0001672_abnormal_embryogenesis/_devel1.11414998
59MP0005380_embryogenesis_phenotype1.11414998
60MP0003984_embryonic_growth_retardation1.08276036
61MP0000383_abnormal_hair_follicle1.08271707
62MP0002970_abnormal_white_adipose1.06187830
63MP0004264_abnormal_extraembryonic_tissu1.05963333
64MP0008932_abnormal_embryonic_tissue1.05270512
65MP0002088_abnormal_embryonic_growth/wei1.02392770
66MP0010678_abnormal_skin_adnexa1.02004143
67MP0005334_abnormal_fat_pad1.00890805
68MP0003115_abnormal_respiratory_system0.99517311
69MP0000427_abnormal_hair_cycle0.98248391
70MP0004233_abnormal_muscle_weight0.98092226
71MP0002210_abnormal_sex_determination0.97610892
72MP0008057_abnormal_DNA_replication0.93561546
73MP0002080_prenatal_lethality0.92939739
74MP0000639_abnormal_adrenal_gland0.92813231
75MP0005623_abnormal_meninges_morphology0.90454792
76MP0008775_abnormal_heart_ventricle0.88313412
77MP0009379_abnormal_foot_pigmentation0.78654541
78MP0003890_abnormal_embryonic-extraembry0.77867171
79MP0005197_abnormal_uvea_morphology0.74308919
80MP0002084_abnormal_developmental_patter0.73539064
81MP0000750_abnormal_muscle_regeneration0.72694526
82MP0006082_CNS_inflammation0.71942304
83MP0000733_abnormal_muscle_development0.70956028
84MP0002060_abnormal_skin_morphology0.69046011
85MP0003567_abnormal_fetal_cardiomyocyte0.67574152
86MP0006035_abnormal_mitochondrial_morpho0.66403222
87MP0005647_abnormal_sex_gland0.64425772
88MP0005621_abnormal_cell_physiology0.63999382
89MP0001731_abnormal_postnatal_growth0.63326250
90MP0001243_abnormal_dermal_layer0.62783986
91MP0002925_abnormal_cardiovascular_devel0.61204203
92MP0004858_abnormal_nervous_system0.59721668
93MP0003943_abnormal_hepatobiliary_system0.59248286
94MP0005193_abnormal_anterior_eye0.58779340
95MP0002085_abnormal_embryonic_tissue0.58424513
96MP0005330_cardiomyopathy0.57984090
97MP0004197_abnormal_fetal_growth/weight/0.57082582
98MP0001145_abnormal_male_reproductive0.56763038
99MP0004272_abnormal_basement_membrane0.55906713
100MP0000534_abnormal_ureter_morphology0.55866240

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)8.03535889
2Aplasia cutis congenita (HP:0001057)7.33823389
3Ankle contracture (HP:0006466)7.27178599
4Protrusio acetabuli (HP:0003179)6.79421117
5Broad metatarsal (HP:0001783)6.42325427
6Wrist flexion contracture (HP:0001239)6.20193815
7Vertebral compression fractures (HP:0002953)5.69023746
8Fragile nails (HP:0001808)4.95804238
9Amelogenesis imperfecta (HP:0000705)4.49529374
10Abnormality of the parietal bone (HP:0002696)4.29207792
11Impulsivity (HP:0100710)3.69734868
12Abnormality of the frontal sinuses (HP:0002687)3.69140939
13Woolly hair (HP:0002224)3.47309287
14Delayed closure of the anterior fontanelle (HP:0001476)3.41416313
15Abnormality of permanent molar morphology (HP:0011071)3.38613909
16Abnormality of the dental root (HP:0006486)3.38613909
17Taurodontia (HP:0000679)3.38613909
18Skin nodule (HP:0200036)3.37414976
19Hip contracture (HP:0003273)3.25683972
20Abnormality of molar (HP:0011077)3.18105142
21Abnormality of molar morphology (HP:0011070)3.18105142
22Right ventricular cardiomyopathy (HP:0011663)3.16507260
23Hyperglycinemia (HP:0002154)3.04789849
24Widely patent fontanelles and sutures (HP:0004492)2.97736306
25Abnormality of the dental pulp (HP:0006479)2.91810407
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91517496
27Hyperglycinuria (HP:0003108)2.87077227
28Narrow nasal bridge (HP:0000446)2.79663152
29Short clavicles (HP:0000894)2.76946200
30Chromsome breakage (HP:0040012)2.70269579
31Oligodactyly (hands) (HP:0001180)2.59390097
32Aplasia/Hypoplasia of the clavicles (HP:0006710)2.54819708
33Micronodular cirrhosis (HP:0001413)2.53344503
34Delayed cranial suture closure (HP:0000270)2.52911091
35Abnormality of dental color (HP:0011073)2.51691462
36Split foot (HP:0001839)2.41267339
37Wide cranial sutures (HP:0010537)2.40428609
38Insulin resistance (HP:0000855)2.37805586
39Birth length less than 3rd percentile (HP:0003561)2.35266629
40Hypergonadotropic hypogonadism (HP:0000815)2.35239876
41Split hand (HP:0001171)2.34683056
42Focal segmental glomerulosclerosis (HP:0000097)2.27147885
43Abnormal sex determination (HP:0012244)2.26867943
44Sex reversal (HP:0012245)2.26867943
45Poikiloderma (HP:0001029)2.26735178
46Fragile skin (HP:0001030)2.25997646
47Esophageal atresia (HP:0002032)2.24916165
48Oligodactyly (HP:0012165)2.23774335
49Trismus (HP:0000211)2.19292472
50Abnormality of the preputium (HP:0100587)2.17523388
51Subacute progressive viral hepatitis (HP:0006572)2.17491164
52Male infertility (HP:0003251)2.16494850
53Aplastic anemia (HP:0001915)2.15354853
54Tarsal synostosis (HP:0008368)2.14298313
55Depressed nasal tip (HP:0000437)2.12165866
56Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.11588778
57Congenital ichthyosiform erythroderma (HP:0007431)2.09626816
58Abnormality of the acetabulum (HP:0003170)2.02314050
59Limited hip movement (HP:0008800)2.00515130
60Absent hand (HP:0004050)1.93398157
61Nuclear cataract (HP:0100018)1.91995182
62Absent radius (HP:0003974)1.89546996
63Aplasia involving forearm bones (HP:0009822)1.86534351
64Absent forearm bone (HP:0003953)1.86534351
65Sparse lateral eyebrow (HP:0005338)1.84474302
66Synostosis involving bones of the feet (HP:0009140)1.84194437
67Synostosis involving bones of the lower limbs (HP:0009138)1.84194437
68Duplication of thumb phalanx (HP:0009942)1.83922520
69Myelodysplasia (HP:0002863)1.82726781
70Bilateral microphthalmos (HP:0007633)1.81681310
71Abnormality of glycine metabolism (HP:0010895)1.79086648
72Abnormality of serine family amino acid metabolism (HP:0010894)1.79086648
73Insulin-resistant diabetes mellitus (HP:0000831)1.74794833
74Breast hypoplasia (HP:0003187)1.73889043
75Ankyloglossia (HP:0010296)1.72854455
76Esophageal varix (HP:0002040)1.72078931
77Duodenal stenosis (HP:0100867)1.70159925
78Small intestinal stenosis (HP:0012848)1.70159925
79Thrombocytosis (HP:0001894)1.69977859
80Coronal craniosynostosis (HP:0004440)1.68058304
81Glomerulosclerosis (HP:0000096)1.67837667
82Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67455590
83Abnormality of pyrimidine metabolism (HP:0004353)1.67189640
84Hyperacusis (HP:0010780)1.65909499
85Duplicated collecting system (HP:0000081)1.63879284
86Reduced subcutaneous adipose tissue (HP:0003758)1.62903176
87Renal cell carcinoma (HP:0005584)1.62732904
88Deviation of the thumb (HP:0009603)1.62405390
89Ureteral duplication (HP:0000073)1.61819833
90Short nail (HP:0001799)1.61632313
91Abnormality of DNA repair (HP:0003254)1.60198495
92Personality changes (HP:0000751)1.59263355
93Ectropion (HP:0000656)1.57204914
94Hyperglycemia (HP:0003074)1.55120096
95Underdeveloped supraorbital ridges (HP:0009891)1.52801198
96Plantar hyperkeratosis (HP:0007556)1.52551983
97Reticulocytopenia (HP:0001896)1.51961796
98Insidious onset (HP:0003587)1.51198598
99Termporal pattern (HP:0011008)1.51198598
100Deep philtrum (HP:0002002)1.50405989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.59750420
2MET3.73965312
3AKT33.48750488
4ICK3.38824734
5MST43.27270330
6BUB13.21911150
7NME13.11330524
8NME23.02003673
9PRKD32.98142802
10WEE12.85317517
11SMG12.45078730
12EPHA22.34692907
13EPHB12.13040455
14PBK2.04161682
15TSSK61.75965886
16TRIB31.73353897
17GSK3A1.57337945
18PTK21.57278326
19EIF2AK11.48793678
20PAK41.47958265
21RPS6KB21.44787603
22TYRO31.43741862
23KDR1.35711096
24CDK121.35023518
25TTK1.30677507
26BMX1.25069520
27MAP3K81.20801802
28LATS21.19932570
29CDK71.11087702
30STK101.09836420
31PRKCI1.05599630
32BRSK21.03785962
33EIF2AK31.01735379
34IRAK31.01325291
35MAP3K101.00681695
36MAP3K70.99789038
37PDGFRA0.99608199
38PLK30.98659211
39BRAF0.97216570
40AURKB0.96702108
41CDK60.87654723
42MTOR0.87127316
43PLK10.86691536
44MAP2K10.85342776
45AKT20.82590826
46SGK30.78493252
47CHEK20.73658295
48PASK0.71428747
49PDK20.71324851
50PTK2B0.67496256
51PTK60.66101504
52PRKG20.62005351
53NEK90.61825872
54LRRK20.61681291
55CHEK10.59301046
56SIK30.58446742
57AURKA0.58366757
58RPS6KA40.57319384
59CDK40.50585558
60BRSK10.49900360
61CDK80.49650551
62PIM10.48700357
63CCNB10.46616724
64CDC70.45959318
65TAF10.43771386
66TESK20.43615743
67CDK10.38989719
68MELK0.36185226
69MAPK110.35633168
70CDK20.35201481
71NEK60.35038956
72EEF2K0.34410808
73ERN10.34293828
74STK380.32477873
75LATS10.32388920
76FER0.31777449
77VRK20.30900155
78DAPK10.29669588
79PDPK10.28181830
80PLK40.28153554
81SCYL20.26580447
82RPS6KA20.25728354
83RPS6KA10.25703251
84MATK0.25418886
85PRKD20.25416654
86PKN20.25266602
87ATR0.24172932
88PAK10.22601419
89MAPK10.20577756
90CDK90.19440877
91RPS6KL10.17841273
92RPS6KC10.17841273
93MAPK140.17546123
94STK40.16559517
95BRD40.16063056
96PNCK0.15625129
97SRC0.14634670
98MAP3K30.14411861
99NEK10.12994667
100TRIM280.12951381

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.45700215
2Cell cycle_Homo sapiens_hsa041103.01369392
3p53 signaling pathway_Homo sapiens_hsa041152.91994717
4Thyroid hormone synthesis_Homo sapiens_hsa049182.61716909
5DNA replication_Homo sapiens_hsa030302.42082426
6Small cell lung cancer_Homo sapiens_hsa052222.22680273
7Prolactin signaling pathway_Homo sapiens_hsa049172.22470212
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.20505825
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.20011325
10N-Glycan biosynthesis_Homo sapiens_hsa005102.19172210
11GnRH signaling pathway_Homo sapiens_hsa049122.04503496
12Autoimmune thyroid disease_Homo sapiens_hsa053201.98635234
13Bladder cancer_Homo sapiens_hsa052191.94117809
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90591108
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89247212
16HIF-1 signaling pathway_Homo sapiens_hsa040661.81496620
17RNA transport_Homo sapiens_hsa030131.74108191
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.70906505
19Rap1 signaling pathway_Homo sapiens_hsa040151.67078084
20Prostate cancer_Homo sapiens_hsa052151.64796680
21Nucleotide excision repair_Homo sapiens_hsa034201.57836992
22Oocyte meiosis_Homo sapiens_hsa041141.54897033
23Mismatch repair_Homo sapiens_hsa034301.51560014
24Folate biosynthesis_Homo sapiens_hsa007901.46661266
25Ras signaling pathway_Homo sapiens_hsa040141.45937758
26mRNA surveillance pathway_Homo sapiens_hsa030151.45290411
27Focal adhesion_Homo sapiens_hsa045101.39716605
28Adherens junction_Homo sapiens_hsa045201.38941216
29Spliceosome_Homo sapiens_hsa030401.29274584
30Base excision repair_Homo sapiens_hsa034101.24946384
31Pathways in cancer_Homo sapiens_hsa052001.23576152
32Hippo signaling pathway_Homo sapiens_hsa043901.22958907
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21195145
34Inositol phosphate metabolism_Homo sapiens_hsa005621.18364143
35Non-homologous end-joining_Homo sapiens_hsa034501.18134467
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13563533
37Proteoglycans in cancer_Homo sapiens_hsa052051.12049101
38Homologous recombination_Homo sapiens_hsa034401.10782969
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09260526
40Thyroid cancer_Homo sapiens_hsa052161.09214857
41Proteasome_Homo sapiens_hsa030501.07335178
42MicroRNAs in cancer_Homo sapiens_hsa052061.03848466
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03497911
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.98508095
45Ribosome_Homo sapiens_hsa030100.93666244
46Viral carcinogenesis_Homo sapiens_hsa052030.92646497
47Basal transcription factors_Homo sapiens_hsa030220.86283838
48Pyrimidine metabolism_Homo sapiens_hsa002400.83951066
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83732332
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83714410
51Basal cell carcinoma_Homo sapiens_hsa052170.83109525
52Fanconi anemia pathway_Homo sapiens_hsa034600.82733038
53Galactose metabolism_Homo sapiens_hsa000520.82420151
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81954537
55Chronic myeloid leukemia_Homo sapiens_hsa052200.81441166
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80736468
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79678050
58One carbon pool by folate_Homo sapiens_hsa006700.78884086
59Notch signaling pathway_Homo sapiens_hsa043300.78350071
60Renal cell carcinoma_Homo sapiens_hsa052110.75587581
61Measles_Homo sapiens_hsa051620.75341866
62Fructose and mannose metabolism_Homo sapiens_hsa000510.73572328
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71813177
64Vitamin B6 metabolism_Homo sapiens_hsa007500.71299562
65Arginine and proline metabolism_Homo sapiens_hsa003300.70595578
66Estrogen signaling pathway_Homo sapiens_hsa049150.70009418
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.69648043
68Tight junction_Homo sapiens_hsa045300.69350494
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68993995
70Hepatitis B_Homo sapiens_hsa051610.66434097
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66218853
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.63855780
73Mineral absorption_Homo sapiens_hsa049780.59865645
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59663388
75Sulfur relay system_Homo sapiens_hsa041220.57913046
76HTLV-I infection_Homo sapiens_hsa051660.57064318
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55669461
78Endometrial cancer_Homo sapiens_hsa052130.54545668
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.52983243
80ECM-receptor interaction_Homo sapiens_hsa045120.52893389
81Acute myeloid leukemia_Homo sapiens_hsa052210.51682016
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51038031
83Melanoma_Homo sapiens_hsa052180.49873387
84Insulin signaling pathway_Homo sapiens_hsa049100.49713170
85Endocytosis_Homo sapiens_hsa041440.49252184
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47769758
87Wnt signaling pathway_Homo sapiens_hsa043100.46416170
88Hedgehog signaling pathway_Homo sapiens_hsa043400.45089018
89Carbon metabolism_Homo sapiens_hsa012000.45079566
90Biosynthesis of amino acids_Homo sapiens_hsa012300.44596696
91Antigen processing and presentation_Homo sapiens_hsa046120.43999409
92FoxO signaling pathway_Homo sapiens_hsa040680.43915546
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43722637
94Epstein-Barr virus infection_Homo sapiens_hsa051690.42638442
95Pentose phosphate pathway_Homo sapiens_hsa000300.38645809
96Vitamin digestion and absorption_Homo sapiens_hsa049770.38575793
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38366025
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38157959
99AMPK signaling pathway_Homo sapiens_hsa041520.36001510
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35110802

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