

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | epoxygenase P450 pathway (GO:0019373) | 5.81948638 |
| 2 | intestinal cholesterol absorption (GO:0030299) | 5.20185781 |
| 3 | exogenous drug catabolic process (GO:0042738) | 5.17510907 |
| 4 | regulation of water loss via skin (GO:0033561) | 5.11083250 |
| 5 | primary alcohol catabolic process (GO:0034310) | 5.03237014 |
| 6 | establishment of skin barrier (GO:0061436) | 4.92324845 |
| 7 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.90444661 |
| 8 | axonemal dynein complex assembly (GO:0070286) | 4.89777582 |
| 9 | intestinal absorption (GO:0050892) | 4.75520838 |
| 10 | intestinal epithelial cell development (GO:0060576) | 4.69860195 |
| 11 | xenobiotic catabolic process (GO:0042178) | 4.37328541 |
| 12 | drug metabolic process (GO:0017144) | 4.36186862 |
| 13 | response to nitrosative stress (GO:0051409) | 4.31965705 |
| 14 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.02942725 |
| 15 | sulfur amino acid catabolic process (GO:0000098) | 4.02207208 |
| 16 | reverse cholesterol transport (GO:0043691) | 3.92701874 |
| 17 | regulation of bile acid biosynthetic process (GO:0070857) | 3.89984414 |
| 18 | multicellular organismal water homeostasis (GO:0050891) | 3.84101610 |
| 19 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.81109957 |
| 20 | hormone catabolic process (GO:0042447) | 3.80696418 |
| 21 | desmosome organization (GO:0002934) | 3.77103292 |
| 22 | NADH metabolic process (GO:0006734) | 3.74178063 |
| 23 | regulation of cholesterol homeostasis (GO:2000188) | 3.72625448 |
| 24 | renal system process involved in regulation of blood volume (GO:0001977) | 3.72502124 |
| 25 | phospholipid efflux (GO:0033700) | 3.65572934 |
| 26 | angiotensin maturation (GO:0002003) | 3.64712839 |
| 27 | establishment of apical/basal cell polarity (GO:0035089) | 3.63563299 |
| 28 | high-density lipoprotein particle remodeling (GO:0034375) | 3.62565292 |
| 29 | interferon-gamma secretion (GO:0072643) | 3.58502820 |
| 30 | tight junction assembly (GO:0070830) | 3.58068449 |
| 31 | piRNA metabolic process (GO:0034587) | 3.52995890 |
| 32 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.52459918 |
| 33 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.51033764 |
| 34 | gap junction assembly (GO:0016264) | 3.50291889 |
| 35 | water homeostasis (GO:0030104) | 3.49220975 |
| 36 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.48414430 |
| 37 | peptide catabolic process (GO:0043171) | 3.47071993 |
| 38 | omega-hydroxylase P450 pathway (GO:0097267) | 3.44803749 |
| 39 | O-glycan processing (GO:0016266) | 3.41368450 |
| 40 | cysteine metabolic process (GO:0006534) | 3.40413028 |
| 41 | regulation of cell-cell adhesion mediated by cadherin (GO:2000047) | 3.39471399 |
| 42 | phenylpropanoid metabolic process (GO:0009698) | 3.38857313 |
| 43 | hemidesmosome assembly (GO:0031581) | 3.37721513 |
| 44 | epithelial cell-cell adhesion (GO:0090136) | 3.36924007 |
| 45 | sex determination (GO:0007530) | 3.36226447 |
| 46 | bile acid and bile salt transport (GO:0015721) | 3.35074084 |
| 47 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.34092325 |
| 48 | proline metabolic process (GO:0006560) | 3.33966584 |
| 49 | plasma lipoprotein particle assembly (GO:0034377) | 3.33683747 |
| 50 | homocysteine metabolic process (GO:0050667) | 3.32788252 |
| 51 | bile acid metabolic process (GO:0008206) | 3.32319495 |
| 52 | regulation of meiosis I (GO:0060631) | 3.31683497 |
| 53 | sodium ion homeostasis (GO:0055078) | 3.31462226 |
| 54 | uronic acid metabolic process (GO:0006063) | 3.30738288 |
| 55 | glucuronate metabolic process (GO:0019585) | 3.30738288 |
| 56 | drug transmembrane transport (GO:0006855) | 3.25739477 |
| 57 | primary alcohol metabolic process (GO:0034308) | 3.24796017 |
| 58 | cilium movement (GO:0003341) | 3.24471130 |
| 59 | COPI coating of Golgi vesicle (GO:0048205) | 3.23571106 |
| 60 | Golgi transport vesicle coating (GO:0048200) | 3.23571106 |
| 61 | cellular glucuronidation (GO:0052695) | 3.21898867 |
| 62 | COPII vesicle coating (GO:0048208) | 3.17544899 |
| 63 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.17108146 |
| 64 | L-phenylalanine catabolic process (GO:0006559) | 3.17108146 |
| 65 | transcytosis (GO:0045056) | 3.14689548 |
| 66 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.14257434 |
| 67 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.14188970 |
| 68 | regulation of cholesterol biosynthetic process (GO:0045540) | 3.14043350 |
| 69 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.13109401 |
| 70 | motile cilium assembly (GO:0044458) | 3.11142486 |
| 71 | regulation of cholesterol esterification (GO:0010872) | 3.09389577 |
| 72 | glutathione derivative biosynthetic process (GO:1901687) | 3.09359743 |
| 73 | glutathione derivative metabolic process (GO:1901685) | 3.09359743 |
| 74 | sex differentiation (GO:0007548) | 3.07461112 |
| 75 | regulation of guanylate cyclase activity (GO:0031282) | 3.05766103 |
| 76 | urea metabolic process (GO:0019627) | 3.05054265 |
| 77 | urea cycle (GO:0000050) | 3.05054265 |
| 78 | proline biosynthetic process (GO:0006561) | 3.02558857 |
| 79 | regulation of male gonad development (GO:2000018) | 3.02310400 |
| 80 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.01387291 |
| 81 | macroautophagy (GO:0016236) | 3.01367974 |
| 82 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 3.00031093 |
| 83 | L-phenylalanine metabolic process (GO:0006558) | 3.00031093 |
| 84 | renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) | 2.99323345 |
| 85 | regulation of protein activation cascade (GO:2000257) | 2.98499540 |
| 86 | ethanol oxidation (GO:0006069) | 2.98227969 |
| 87 | drug catabolic process (GO:0042737) | 2.97590855 |
| 88 | positive regulation of male gonad development (GO:2000020) | 2.97387755 |
| 89 | regulation of cardioblast differentiation (GO:0051890) | 2.96466317 |
| 90 | sphingomyelin metabolic process (GO:0006684) | 2.95407937 |
| 91 | protein-lipid complex assembly (GO:0065005) | 2.91852413 |
| 92 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.91558094 |
| 93 | serine family amino acid catabolic process (GO:0009071) | 2.91140010 |
| 94 | excretion (GO:0007588) | 2.90936664 |
| 95 | phospholipid homeostasis (GO:0055091) | 2.89480630 |
| 96 | amino-acid betaine metabolic process (GO:0006577) | 2.89028041 |
| 97 | lipoprotein metabolic process (GO:0042157) | 2.86252723 |
| 98 | flavonoid metabolic process (GO:0009812) | 2.85691233 |
| 99 | benzene-containing compound metabolic process (GO:0042537) | 2.85400735 |
| 100 | lung epithelium development (GO:0060428) | 2.84846256 |
| 101 | regulation of complement activation (GO:0030449) | 2.83275536 |
| 102 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 2.82775678 |
| 103 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 2.82775678 |
| 104 | endocrine process (GO:0050886) | 2.82775678 |
| 105 | aromatic amino acid family catabolic process (GO:0009074) | 2.82700864 |
| 106 | regulation of hippo signaling (GO:0035330) | 2.81165743 |
| 107 | oocyte development (GO:0048599) | 2.81023340 |
| 108 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 2.80910767 |
| 109 | cholesterol efflux (GO:0033344) | 2.80387960 |
| 110 | linoleic acid metabolic process (GO:0043651) | 2.79818703 |
| 111 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.79464998 |
| 112 | establishment of monopolar cell polarity (GO:0061162) | 2.79464998 |
| 113 | vitamin transport (GO:0051180) | 2.78911509 |
| 114 | drug transport (GO:0015893) | 2.77232031 |
| 115 | columnar/cuboidal epithelial cell development (GO:0002066) | 2.77214689 |
| 116 | surfactant homeostasis (GO:0043129) | 2.75639805 |
| 117 | alpha-linolenic acid metabolic process (GO:0036109) | 2.73707683 |
| 118 | protein-lipid complex remodeling (GO:0034368) | 2.72904763 |
| 119 | macromolecular complex remodeling (GO:0034367) | 2.72904763 |
| 120 | plasma lipoprotein particle remodeling (GO:0034369) | 2.72904763 |
| 121 | cell-cell junction assembly (GO:0007043) | 2.72691086 |
| 122 | nitrogen cycle metabolic process (GO:0071941) | 2.72190628 |
| 123 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.71538609 |
| 124 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.71248817 |
| 125 | fructose metabolic process (GO:0006000) | 2.70638951 |
| 126 | indole-containing compound catabolic process (GO:0042436) | 2.69661979 |
| 127 | indolalkylamine catabolic process (GO:0046218) | 2.69661979 |
| 128 | tryptophan catabolic process (GO:0006569) | 2.69661979 |
| 129 | negative regulation of sterol transport (GO:0032372) | 2.69531186 |
| 130 | negative regulation of cholesterol transport (GO:0032375) | 2.69531186 |
| 131 | cholesterol homeostasis (GO:0042632) | 2.69404747 |
| 132 | synaptonemal complex assembly (GO:0007130) | 2.69196326 |
| 133 | positive regulation of lipid catabolic process (GO:0050996) | 2.69169637 |
| 134 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.68924035 |
| 135 | xenobiotic metabolic process (GO:0006805) | 2.68906927 |
| 136 | establishment or maintenance of apical/basal cell polarity (GO:0035088) | 2.68345828 |
| 137 | establishment or maintenance of bipolar cell polarity (GO:0061245) | 2.68345828 |
| 138 | acylglycerol homeostasis (GO:0055090) | 2.68101993 |
| 139 | triglyceride homeostasis (GO:0070328) | 2.68101993 |
| 140 | epithelial structure maintenance (GO:0010669) | 2.67463570 |
| 141 | protein autoprocessing (GO:0016540) | 2.67245282 |
| 142 | diterpenoid biosynthetic process (GO:0016102) | 2.67182503 |
| 143 | regulation of triglyceride catabolic process (GO:0010896) | 2.67024897 |
| 144 | regulation of cholesterol metabolic process (GO:0090181) | 2.66405747 |
| 145 | heme transport (GO:0015886) | 2.66211343 |
| 146 | embryonic foregut morphogenesis (GO:0048617) | 2.66183654 |
| 147 | vitamin transmembrane transport (GO:0035461) | 2.65601952 |
| 148 | sterol homeostasis (GO:0055092) | 2.65249610 |
| 149 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.64298645 |
| 150 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.64002939 |
| 151 | response to misfolded protein (GO:0051788) | 2.62820864 |
| 152 | L-ascorbic acid metabolic process (GO:0019852) | 2.62420435 |
| 153 | ethanol metabolic process (GO:0006067) | 2.61841938 |
| 154 | positive regulation of triglyceride lipase activity (GO:0061365) | 2.57601485 |
| 155 | positive regulation of lipoprotein lipase activity (GO:0051006) | 2.57601485 |
| 156 | tryptophan metabolic process (GO:0006568) | 2.57116383 |
| 157 | cholesterol transport (GO:0030301) | 2.55713339 |
| 158 | sterol transport (GO:0015918) | 2.55713339 |
| 159 | kynurenine metabolic process (GO:0070189) | 2.55187680 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 6.24107525 |
| 2 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 5.21559668 |
| 3 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 4.00705633 |
| 4 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 3.92052865 |
| 5 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 3.39597877 |
| 6 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.13048517 |
| 7 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.04577040 |
| 8 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 2.98334110 |
| 9 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.81167437 |
| 10 | * ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.67995356 |
| 11 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.44797268 |
| 12 | GATA4_25053715_ChIP-Seq_YYC3_Human | 2.44727284 |
| 13 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.44357114 |
| 14 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.34308526 |
| 15 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.27773997 |
| 16 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.21997686 |
| 17 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.21772228 |
| 18 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.19075573 |
| 19 | GATA1_22025678_ChIP-Seq_K562_Human | 2.15368537 |
| 20 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 2.14341954 |
| 21 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 2.13628892 |
| 22 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.04949144 |
| 23 | * ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.96285192 |
| 24 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.92223341 |
| 25 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.82715935 |
| 26 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.82538347 |
| 27 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.78233222 |
| 28 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.77426346 |
| 29 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.76331770 |
| 30 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.75687246 |
| 31 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.75687246 |
| 32 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.75687246 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.74903920 |
| 34 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.72141345 |
| 35 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.68084099 |
| 36 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.67496184 |
| 37 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.66744486 |
| 38 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.62015392 |
| 39 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.54138932 |
| 40 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.52279123 |
| 41 | * GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.52217272 |
| 42 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.49411627 |
| 43 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.45511362 |
| 44 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.45511362 |
| 45 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.44652614 |
| 46 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.43906663 |
| 47 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.42026334 |
| 48 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.40778487 |
| 49 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.40376834 |
| 50 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.39723546 |
| 51 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.38401570 |
| 52 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.36552869 |
| 53 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.34959677 |
| 54 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.34250333 |
| 55 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.32473798 |
| 56 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.31935924 |
| 57 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.31420298 |
| 58 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.29355310 |
| 59 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.27398318 |
| 60 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.24836519 |
| 61 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.22275197 |
| 62 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.22063592 |
| 63 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.21796057 |
| 64 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 1.19385789 |
| 65 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.19248612 |
| 66 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.18798905 |
| 67 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.18546788 |
| 68 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.17438880 |
| 69 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.16659727 |
| 70 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.13323116 |
| 71 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.13032302 |
| 72 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 1.12740917 |
| 73 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.12194204 |
| 74 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.11459897 |
| 75 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.10271574 |
| 76 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.09811897 |
| 77 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.09039130 |
| 78 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.08321064 |
| 79 | * FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.07995253 |
| 80 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.07525066 |
| 81 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.06575003 |
| 82 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.05653647 |
| 83 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.04701547 |
| 84 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.04630851 |
| 85 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.03596343 |
| 86 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.03185589 |
| 87 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.01095195 |
| 88 | * ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.01014371 |
| 89 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.00617015 |
| 90 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.00104633 |
| 91 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.99965622 |
| 92 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.99929877 |
| 93 | * KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.98394016 |
| 94 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.96114738 |
| 95 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.94681321 |
| 96 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.93964846 |
| 97 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.93859476 |
| 98 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.92559206 |
| 99 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.91118370 |
| 100 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.89388606 |
| 101 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.86828701 |
| 102 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.86334405 |
| 103 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.86092015 |
| 104 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.85406516 |
| 105 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.83447751 |
| 106 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.83275354 |
| 107 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.82787234 |
| 108 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.82768970 |
| 109 | KAP1_27257070_Chip-Seq_ESCs_Mouse | 0.82664428 |
| 110 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.80447707 |
| 111 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.79488229 |
| 112 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.79174133 |
| 113 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.77650683 |
| 114 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.77065918 |
| 115 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.76840281 |
| 116 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.76004237 |
| 117 | NANOG_18692474_ChIP-Seq_MESCs_Mouse | 0.75628512 |
| 118 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.75294260 |
| 119 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.71489540 |
| 120 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.71255876 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 4.48643315 |
| 2 | MP0010234_abnormal_vibrissa_follicle | 4.42176532 |
| 3 | MP0005360_urolithiasis | 3.80080499 |
| 4 | MP0005085_abnormal_gallbladder_physiolo | 3.55702976 |
| 5 | MP0005365_abnormal_bile_salt | 3.11506718 |
| 6 | MP0005377_hearing/vestibular/ear_phenot | 3.05399047 |
| 7 | MP0003878_abnormal_ear_physiology | 3.05399047 |
| 8 | MP0004264_abnormal_extraembryonic_tissu | 3.04396230 |
| 9 | MP0001666_abnormal_nutrient_absorption | 2.97054155 |
| 10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.89634131 |
| 11 | MP0002796_impaired_skin_barrier | 2.85917080 |
| 12 | MP0008995_early_reproductive_senescence | 2.54216441 |
| 13 | MP0003941_abnormal_skin_development | 2.48137109 |
| 14 | MP0003252_abnormal_bile_duct | 2.21803309 |
| 15 | MP0003195_calcinosis | 2.14035161 |
| 16 | MP0000537_abnormal_urethra_morphology | 2.13897901 |
| 17 | MP0004019_abnormal_vitamin_homeostasis | 2.09300783 |
| 18 | MP0009840_abnormal_foam_cell | 1.95700174 |
| 19 | MP0010329_abnormal_lipoprotein_level | 1.94503222 |
| 20 | MP0009379_abnormal_foot_pigmentation | 1.89878283 |
| 21 | MP0009780_abnormal_chondrocyte_physiolo | 1.85936211 |
| 22 | MP0004782_abnormal_surfactant_physiolog | 1.85250658 |
| 23 | MP0010678_abnormal_skin_adnexa | 1.78046366 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 1.73434478 |
| 25 | MP0005501_abnormal_skin_physiology | 1.68027107 |
| 26 | MP0003191_abnormal_cellular_cholesterol | 1.60678748 |
| 27 | MP0002098_abnormal_vibrissa_morphology | 1.58598021 |
| 28 | MP0000566_synostosis | 1.56118133 |
| 29 | MP0003693_abnormal_embryo_hatching | 1.55539600 |
| 30 | MP0002254_reproductive_system_inflammat | 1.55478362 |
| 31 | MP0005451_abnormal_body_composition | 1.48674411 |
| 32 | MP0003786_premature_aging | 1.48307560 |
| 33 | MP0002138_abnormal_hepatobiliary_system | 1.47352464 |
| 34 | MP0001664_abnormal_digestion | 1.46990551 |
| 35 | MP0003183_abnormal_peptide_metabolism | 1.45783911 |
| 36 | MP0003718_maternal_effect | 1.42507907 |
| 37 | MP0008877_abnormal_DNA_methylation | 1.40984636 |
| 38 | MP0005083_abnormal_biliary_tract | 1.40161122 |
| 39 | MP0003705_abnormal_hypodermis_morpholog | 1.36187549 |
| 40 | MP0005647_abnormal_sex_gland | 1.31473965 |
| 41 | MP0005332_abnormal_amino_acid | 1.31359559 |
| 42 | MP0001765_abnormal_ion_homeostasis | 1.30943617 |
| 43 | MP0000383_abnormal_hair_follicle | 1.29212391 |
| 44 | MP0005408_hypopigmentation | 1.28458580 |
| 45 | MP0005636_abnormal_mineral_homeostasis | 1.24560761 |
| 46 | MP0005409_darkened_coat_color | 1.21914879 |
| 47 | MP0002060_abnormal_skin_morphology | 1.19894971 |
| 48 | MP0004043_abnormal_pH_regulation | 1.19551255 |
| 49 | MP0010155_abnormal_intestine_physiology | 1.17036758 |
| 50 | MP0009643_abnormal_urine_homeostasis | 1.16795092 |
| 51 | MP0001216_abnormal_epidermal_layer | 1.16337566 |
| 52 | MP0000462_abnormal_digestive_system | 1.16043827 |
| 53 | MP0010352_gastrointestinal_tract_polyps | 1.13888642 |
| 54 | MP0003119_abnormal_digestive_system | 1.13632234 |
| 55 | MP0003453_abnormal_keratinocyte_physiol | 1.12735644 |
| 56 | MP0002132_abnormal_respiratory_system | 1.12682671 |
| 57 | MP0009053_abnormal_anal_canal | 1.12205463 |
| 58 | MP0000490_abnormal_crypts_of | 1.08039686 |
| 59 | MP0000609_abnormal_liver_physiology | 1.03831618 |
| 60 | MP0003866_abnormal_defecation | 1.03131761 |
| 61 | MP0002909_abnormal_adrenal_gland | 1.02232966 |
| 62 | MP0005395_other_phenotype | 1.02114933 |
| 63 | MP0000613_abnormal_salivary_gland | 1.00638994 |
| 64 | MP0003315_abnormal_perineum_morphology | 1.00453088 |
| 65 | MP0005220_abnormal_exocrine_pancreas | 0.99857380 |
| 66 | MP0002249_abnormal_larynx_morphology | 0.99496561 |
| 67 | MP0010030_abnormal_orbit_morphology | 0.98797402 |
| 68 | MP0009384_cardiac_valve_regurgitation | 0.98541597 |
| 69 | MP0001756_abnormal_urination | 0.98113799 |
| 70 | MP0001849_ear_inflammation | 0.96816219 |
| 71 | MP0003890_abnormal_embryonic-extraembry | 0.95632310 |
| 72 | MP0003868_abnormal_feces_composition | 0.93793320 |
| 73 | MP0002118_abnormal_lipid_homeostasis | 0.91073173 |
| 74 | MP0005076_abnormal_cell_differentiation | 0.90807171 |
| 75 | MP0002136_abnormal_kidney_physiology | 0.90565989 |
| 76 | MP0005248_abnormal_Harderian_gland | 0.90320120 |
| 77 | MP0001873_stomach_inflammation | 0.88638674 |
| 78 | MP0000678_abnormal_parathyroid_gland | 0.88273787 |
| 79 | MP0002877_abnormal_melanocyte_morpholog | 0.87598777 |
| 80 | MP0004147_increased_porphyrin_level | 0.86262613 |
| 81 | MP0004858_abnormal_nervous_system | 0.85779642 |
| 82 | MP0006054_spinal_hemorrhage | 0.85068857 |
| 83 | MP0003936_abnormal_reproductive_system | 0.84886833 |
| 84 | MP0000427_abnormal_hair_cycle | 0.83606371 |
| 85 | MP0004957_abnormal_blastocyst_morpholog | 0.82649836 |
| 86 | MP0000377_abnormal_hair_follicle | 0.81848985 |
| 87 | MP0000467_abnormal_esophagus_morphology | 0.81622323 |
| 88 | MP0003283_abnormal_digestive_organ | 0.81316413 |
| 89 | MP0001730_embryonic_growth_arrest | 0.79587351 |
| 90 | MP0004133_heterotaxia | 0.79174791 |
| 91 | MP0003115_abnormal_respiratory_system | 0.79156097 |
| 92 | MP0001346_abnormal_lacrimal_gland | 0.78785212 |
| 93 | MP0000538_abnormal_urinary_bladder | 0.78550017 |
| 94 | MP0002210_abnormal_sex_determination | 0.78126142 |
| 95 | MP0000653_abnormal_sex_gland | 0.77825635 |
| 96 | MP0000579_abnormal_nail_morphology | 0.76729904 |
| 97 | MP0001145_abnormal_male_reproductive | 0.75933356 |
| 98 | MP0003566_abnormal_cell_adhesion | 0.74524717 |
| 99 | MP0001881_abnormal_mammary_gland | 0.73535150 |
| 100 | MP0005319_abnormal_enzyme/_coenzyme | 0.73475302 |
| 101 | MP0004272_abnormal_basement_membrane | 0.72921491 |
| 102 | MP0000647_abnormal_sebaceous_gland | 0.72767659 |
| 103 | MP0005381_digestive/alimentary_phenotyp | 0.71722328 |
| 104 | MP0003186_abnormal_redox_activity | 0.70657994 |
| 105 | MP0002160_abnormal_reproductive_system | 0.70445503 |
| 106 | MP0004947_skin_inflammation | 0.70267434 |
| 107 | MP0005670_abnormal_white_adipose | 0.69805337 |
| 108 | MP0000627_abnormal_mammary_gland | 0.69625568 |
| 109 | MP0001188_hyperpigmentation | 0.69612484 |
| 110 | MP0000516_abnormal_urinary_system | 0.69355257 |
| 111 | MP0005367_renal/urinary_system_phenotyp | 0.69355257 |
| 112 | MP0001485_abnormal_pinna_reflex | 0.69084591 |
| 113 | MP0010771_integument_phenotype | 0.68904410 |
| 114 | MP0000477_abnormal_intestine_morphology | 0.67679454 |
| 115 | MP0003638_abnormal_response/metabolism_ | 0.67530903 |
| 116 | MP0000762_abnormal_tongue_morphology | 0.66705734 |
| 117 | MP0001929_abnormal_gametogenesis | 0.66447081 |
| 118 | MP0002277_abnormal_respiratory_mucosa | 0.66397535 |
| 119 | MP0005389_reproductive_system_phenotype | 0.65984737 |
| 120 | MP0002653_abnormal_ependyma_morphology | 0.65947830 |
| 121 | MP0001919_abnormal_reproductive_system | 0.65820890 |
| 122 | MP0002168_other_aberrant_phenotype | 0.65413984 |
| 123 | MP0001764_abnormal_homeostasis | 0.64966430 |
| 124 | MP0000470_abnormal_stomach_morphology | 0.64605558 |
| 125 | MP0009672_abnormal_birth_weight | 0.64477616 |
| 126 | MP0002876_abnormal_thyroid_physiology | 0.64465730 |
| 127 | MP0003879_abnormal_hair_cell | 0.64204535 |
| 128 | MP0005275_abnormal_skin_tensile | 0.64140408 |
| 129 | MP0005023_abnormal_wound_healing | 0.64089320 |
| 130 | MP0001663_abnormal_digestive_system | 0.62284255 |
| 131 | MP0002089_abnormal_postnatal_growth/wei | 0.60203085 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.49133398 |
| 2 | Right ventricular cardiomyopathy (HP:0011663) | 4.72878165 |
| 3 | Intrahepatic cholestasis (HP:0001406) | 4.71121807 |
| 4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.64380905 |
| 5 | Abnormal respiratory motile cilium physiology (HP:0012261) | 4.54150110 |
| 6 | Abnormal respiratory motile cilium morphology (HP:0005938) | 4.48337141 |
| 7 | Abnormal respiratory epithelium morphology (HP:0012253) | 4.48337141 |
| 8 | Rhinitis (HP:0012384) | 4.44101444 |
| 9 | Abnormal ciliary motility (HP:0012262) | 4.33993659 |
| 10 | Absent/shortened dynein arms (HP:0200106) | 4.17370370 |
| 11 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.17370370 |
| 12 | Male infertility (HP:0003251) | 4.08393277 |
| 13 | Hypobetalipoproteinemia (HP:0003563) | 3.81308626 |
| 14 | Decreased circulating renin level (HP:0003351) | 3.70006998 |
| 15 | Conjugated hyperbilirubinemia (HP:0002908) | 3.63965543 |
| 16 | Bronchiectasis (HP:0002110) | 3.62786643 |
| 17 | Abnormality of renin-angiotensin system (HP:0000847) | 3.57890501 |
| 18 | Fat malabsorption (HP:0002630) | 3.53084690 |
| 19 | Malnutrition (HP:0004395) | 3.51364613 |
| 20 | Onycholysis (HP:0001806) | 3.39487645 |
| 21 | Hydroxyprolinuria (HP:0003080) | 3.25206018 |
| 22 | Abnormality of proline metabolism (HP:0010907) | 3.25206018 |
| 23 | 11 pairs of ribs (HP:0000878) | 3.08632665 |
| 24 | Hypoglycemic coma (HP:0001325) | 3.03416517 |
| 25 | Ileus (HP:0002595) | 3.03032207 |
| 26 | Gout (HP:0001997) | 2.99171150 |
| 27 | Hypolipoproteinemia (HP:0010981) | 2.98184220 |
| 28 | Hypoplasia of the uterus (HP:0000013) | 2.97479543 |
| 29 | Deep venous thrombosis (HP:0002625) | 2.95967823 |
| 30 | Nasal polyposis (HP:0100582) | 2.91933968 |
| 31 | Hyperglycinuria (HP:0003108) | 2.89379919 |
| 32 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.88207111 |
| 33 | Xanthomatosis (HP:0000991) | 2.87256156 |
| 34 | Azoospermia (HP:0000027) | 2.86730072 |
| 35 | Pili torti (HP:0003777) | 2.86230850 |
| 36 | Hyperaldosteronism (HP:0000859) | 2.78598680 |
| 37 | Esophageal varix (HP:0002040) | 2.77396473 |
| 38 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.76777882 |
| 39 | Facial shape deformation (HP:0011334) | 2.76570724 |
| 40 | Potter facies (HP:0002009) | 2.76570724 |
| 41 | Complement deficiency (HP:0004431) | 2.73120898 |
| 42 | Abnormal biliary tract morphology (HP:0012440) | 2.72387308 |
| 43 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.71519651 |
| 44 | Gonadal dysgenesis (HP:0000133) | 2.69625521 |
| 45 | Hyperglycemia (HP:0003074) | 2.67793530 |
| 46 | Alkalosis (HP:0001948) | 2.64001411 |
| 47 | Proximal tubulopathy (HP:0000114) | 2.61678142 |
| 48 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.58723531 |
| 49 | Hyperactive renin-angiotensin system (HP:0000841) | 2.54606554 |
| 50 | Abnormality of the nasal mucosa (HP:0000433) | 2.54406127 |
| 51 | Micronodular cirrhosis (HP:0001413) | 2.53385568 |
| 52 | Hyperglycinemia (HP:0002154) | 2.52147241 |
| 53 | Abnormal pancreas size (HP:0012094) | 2.48340836 |
| 54 | Fragile nails (HP:0001808) | 2.46878021 |
| 55 | Chronic bronchitis (HP:0004469) | 2.46750521 |
| 56 | Abnormality of purine metabolism (HP:0004352) | 2.45821916 |
| 57 | Hemorrhage of the eye (HP:0011885) | 2.42081072 |
| 58 | Hypoalphalipoproteinemia (HP:0003233) | 2.41328058 |
| 59 | Milia (HP:0001056) | 2.41059284 |
| 60 | Bronchitis (HP:0012387) | 2.40911879 |
| 61 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.39788632 |
| 62 | Abnormality of complement system (HP:0005339) | 2.37016596 |
| 63 | Widely patent fontanelles and sutures (HP:0004492) | 2.35939303 |
| 64 | Steatorrhea (HP:0002570) | 2.35552416 |
| 65 | Gonadotropin excess (HP:0000837) | 2.35339727 |
| 66 | Missing ribs (HP:0000921) | 2.34643352 |
| 67 | Villous atrophy (HP:0011473) | 2.33319281 |
| 68 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.33319281 |
| 69 | Systemic lupus erythematosus (HP:0002725) | 2.32559686 |
| 70 | Hyperkalemia (HP:0002153) | 2.31881821 |
| 71 | Renal salt wasting (HP:0000127) | 2.31741993 |
| 72 | Plantar hyperkeratosis (HP:0007556) | 2.31619048 |
| 73 | Glomerulosclerosis (HP:0000096) | 2.31435936 |
| 74 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.31263932 |
| 75 | Curly hair (HP:0002212) | 2.30606673 |
| 76 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.28931241 |
| 77 | Abnormality of glycine metabolism (HP:0010895) | 2.28931241 |
| 78 | Abnormality of nucleobase metabolism (HP:0010932) | 2.28897920 |
| 79 | Bronchomalacia (HP:0002780) | 2.27493906 |
| 80 | Abnormality of the intrinsic pathway (HP:0010989) | 2.26877830 |
| 81 | Prolonged partial thromboplastin time (HP:0003645) | 2.26539710 |
| 82 | Glomerulonephritis (HP:0000099) | 2.26266375 |
| 83 | Rectal prolapse (HP:0002035) | 2.25996753 |
| 84 | Abnormality of chloride homeostasis (HP:0011422) | 2.24941946 |
| 85 | Lip pit (HP:0100267) | 2.24115384 |
| 86 | Biliary tract neoplasm (HP:0100574) | 2.23058321 |
| 87 | Vascular calcification (HP:0004934) | 2.22682367 |
| 88 | Germ cell neoplasia (HP:0100728) | 2.22412253 |
| 89 | Hyperphosphatemia (HP:0002905) | 2.22403349 |
| 90 | Abdominal distention (HP:0003270) | 2.21570711 |
| 91 | Abnormal hair laboratory examination (HP:0003328) | 2.21055914 |
| 92 | Dehydration (HP:0001944) | 2.20233111 |
| 93 | Abnormality of vitamin metabolism (HP:0100508) | 2.19660603 |
| 94 | Rickets (HP:0002748) | 2.19411016 |
| 95 | Bifid scrotum (HP:0000048) | 2.18005248 |
| 96 | Metabolic alkalosis (HP:0200114) | 2.17679007 |
| 97 | Abnormal sex determination (HP:0012244) | 2.17660969 |
| 98 | Sex reversal (HP:0012245) | 2.17660969 |
| 99 | Focal segmental glomerulosclerosis (HP:0000097) | 2.16439667 |
| 100 | Hyponatremia (HP:0002902) | 2.16433405 |
| 101 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.16367498 |
| 102 | Abnormal spermatogenesis (HP:0008669) | 2.13786396 |
| 103 | Hyperuricemia (HP:0002149) | 2.13160790 |
| 104 | Increased purine levels (HP:0004368) | 2.13160790 |
| 105 | Hypotension (HP:0002615) | 2.12414441 |
| 106 | Abnormality of the dental root (HP:0006486) | 2.11613417 |
| 107 | Taurodontia (HP:0000679) | 2.11613417 |
| 108 | Abnormality of permanent molar morphology (HP:0011071) | 2.11613417 |
| 109 | Woolly hair (HP:0002224) | 2.08988630 |
| 110 | Hypoplasia of dental enamel (HP:0006297) | 2.08961794 |
| 111 | Hypoglycemic seizures (HP:0002173) | 2.08301271 |
| 112 | Abnormality of vitamin B metabolism (HP:0004340) | 2.07476899 |
| 113 | Epidermoid cyst (HP:0200040) | 2.05881156 |
| 114 | Late onset (HP:0003584) | 2.05181310 |
| 115 | Infertility (HP:0000789) | 2.04567774 |
| 116 | Male pseudohermaphroditism (HP:0000037) | 2.03973140 |
| 117 | Hypoplastic labia majora (HP:0000059) | 2.03784498 |
| 118 | Pigmentary retinal degeneration (HP:0001146) | 2.02744046 |
| 119 | Flat acetabular roof (HP:0003180) | 2.02557617 |
| 120 | Nausea (HP:0002018) | 2.02555740 |
| 121 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.02549310 |
| 122 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.02268576 |
| 123 | Abnormality of the common coagulation pathway (HP:0010990) | 2.01600859 |
| 124 | Hand muscle atrophy (HP:0009130) | 1.99857398 |
| 125 | Megaloblastic anemia (HP:0001889) | 1.99315597 |
| 126 | Abnormality of the gastric mucosa (HP:0004295) | 1.97999285 |
| 127 | Hyperammonemia (HP:0001987) | 1.97969207 |
| 128 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.97711249 |
| 129 | Osteomalacia (HP:0002749) | 1.95609573 |
| 130 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.95049928 |
| 131 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.93547770 |
| 132 | Abnormality of the dental pulp (HP:0006479) | 1.92779194 |
| 133 | Corneal erosion (HP:0200020) | 1.90718683 |
| 134 | Breast carcinoma (HP:0003002) | 1.89335979 |
| 135 | Pseudobulbar signs (HP:0002200) | 1.89192806 |
| 136 | Abnormality of molar (HP:0011077) | 1.88939823 |
| 137 | Abnormality of molar morphology (HP:0011070) | 1.88939823 |
| 138 | Abnormal tarsal ossification (HP:0008369) | 1.87964172 |
| 139 | Glycosuria (HP:0003076) | 1.87873617 |
| 140 | Abnormality of urine glucose concentration (HP:0011016) | 1.87873617 |
| 141 | Cardiovascular calcification (HP:0011915) | 1.87023569 |
| 142 | Nephritis (HP:0000123) | 1.86784486 |
| 143 | Symptomatic seizures (HP:0011145) | 1.86255262 |
| 144 | Shawl scrotum (HP:0000049) | 1.83873466 |
| 145 | Degeneration of anterior horn cells (HP:0002398) | 1.83212075 |
| 146 | Abnormality of the anterior horn cell (HP:0006802) | 1.83212075 |
| 147 | Alopecia of scalp (HP:0002293) | 1.82852686 |
| 148 | Amelogenesis imperfecta (HP:0000705) | 1.77158052 |
| 149 | Visceral angiomatosis (HP:0100761) | 1.73843200 |
| 150 | Wide cranial sutures (HP:0010537) | 1.72734187 |
| 151 | Partial duplication of thumb phalanx (HP:0009944) | 1.72250242 |
| 152 | Abnormality of sodium homeostasis (HP:0010931) | 1.71124106 |
| 153 | Abnormality of potassium homeostasis (HP:0011042) | 1.68732467 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA2 | 6.96959247 |
| 2 | LATS1 | 3.74785528 |
| 3 | STK38L | 3.20921817 |
| 4 | FRK | 2.82139472 |
| 5 | MST1R | 2.81267289 |
| 6 | RPS6KB2 | 2.54981638 |
| 7 | SMG1 | 2.53757331 |
| 8 | CDK12 | 2.39642242 |
| 9 | MAP2K2 | 2.35558751 |
| 10 | MST4 | 2.31069642 |
| 11 | AKT3 | 2.22108700 |
| 12 | PTK6 | 2.08324297 |
| 13 | MAP3K2 | 2.05576203 |
| 14 | RIPK1 | 1.95667963 |
| 15 | EEF2K | 1.76437846 |
| 16 | BCKDK | 1.75183981 |
| 17 | MAPK15 | 1.72986716 |
| 18 | PRKCI | 1.65297332 |
| 19 | MAP3K3 | 1.64089798 |
| 20 | NUAK1 | 1.62808738 |
| 21 | MAP3K10 | 1.61158015 |
| 22 | STK39 | 1.60726716 |
| 23 | FER | 1.54024676 |
| 24 | TTK | 1.50307750 |
| 25 | MET | 1.44029353 |
| 26 | PTK2 | 1.42197854 |
| 27 | MAP3K12 | 1.38195266 |
| 28 | LMTK2 | 1.37439411 |
| 29 | STK3 | 1.33325881 |
| 30 | WNK3 | 1.32659070 |
| 31 | PLK4 | 1.27832639 |
| 32 | IRAK3 | 1.25694705 |
| 33 | BRD4 | 1.23531527 |
| 34 | TESK1 | 1.22013383 |
| 35 | TAOK3 | 1.21261028 |
| 36 | OXSR1 | 1.19472704 |
| 37 | SIK1 | 1.17074712 |
| 38 | ZAK | 1.12696967 |
| 39 | PAK4 | 1.11458280 |
| 40 | NEK6 | 1.11371902 |
| 41 | EPHB2 | 1.04327810 |
| 42 | NEK9 | 1.01230239 |
| 43 | INSRR | 1.00925632 |
| 44 | ERN1 | 1.00881471 |
| 45 | NME1 | 0.99737910 |
| 46 | FGFR2 | 0.99559356 |
| 47 | MAPKAPK3 | 0.98168463 |
| 48 | ERBB4 | 0.93841600 |
| 49 | TRIB3 | 0.89702765 |
| 50 | WEE1 | 0.89427122 |
| 51 | WNK4 | 0.84910299 |
| 52 | MTOR | 0.84889054 |
| 53 | LATS2 | 0.84740620 |
| 54 | STK10 | 0.84686641 |
| 55 | PRKD3 | 0.82128285 |
| 56 | FGFR4 | 0.82079772 |
| 57 | ERBB2 | 0.82017559 |
| 58 | PKN2 | 0.81618856 |
| 59 | TNIK | 0.81527698 |
| 60 | CHUK | 0.79993337 |
| 61 | MAP2K1 | 0.79620761 |
| 62 | AURKB | 0.75283093 |
| 63 | PIK3CA | 0.72733253 |
| 64 | PASK | 0.72627933 |
| 65 | CDK7 | 0.70250385 |
| 66 | TYRO3 | 0.69013009 |
| 67 | MYLK | 0.67186787 |
| 68 | NLK | 0.65805962 |
| 69 | PDK4 | 0.63763714 |
| 70 | PDK3 | 0.63763714 |
| 71 | TSSK6 | 0.63519532 |
| 72 | PDPK1 | 0.60972368 |
| 73 | CDK9 | 0.60124923 |
| 74 | MELK | 0.59062425 |
| 75 | ACVR1B | 0.58277676 |
| 76 | MAP3K8 | 0.57451474 |
| 77 | TAOK1 | 0.57066496 |
| 78 | DYRK1B | 0.56828309 |
| 79 | MAP3K9 | 0.56745506 |
| 80 | NEK2 | 0.56395465 |
| 81 | PLK1 | 0.55252588 |
| 82 | SCYL2 | 0.55111014 |
| 83 | DAPK2 | 0.54840701 |
| 84 | EPHB1 | 0.53670891 |
| 85 | PRKG2 | 0.53655593 |
| 86 | BMX | 0.53347122 |
| 87 | FGFR3 | 0.52485258 |
| 88 | SRPK1 | 0.52026838 |
| 89 | DMPK | 0.50334142 |
| 90 | GRK1 | 0.50139059 |
| 91 | PBK | 0.50051944 |
| 92 | PRKAA2 | 0.48652726 |
| 93 | RPS6KA2 | 0.47104880 |
| 94 | SGK3 | 0.43705305 |
| 95 | BUB1 | 0.43319513 |
| 96 | CDK6 | 0.43128290 |
| 97 | BCR | 0.41224952 |
| 98 | CSNK1E | 0.40140827 |
| 99 | MAP3K1 | 0.38028044 |
| 100 | MAP2K6 | 0.37939234 |
| 101 | CDC42BPA | 0.37721111 |
| 102 | PAK3 | 0.37691045 |
| 103 | SGK2 | 0.36712822 |
| 104 | TESK2 | 0.36154632 |
| 105 | PRKCZ | 0.36106723 |
| 106 | GSK3A | 0.35443758 |
| 107 | AKT2 | 0.34839706 |
| 108 | STK24 | 0.34491373 |
| 109 | EPHA3 | 0.34466348 |
| 110 | CAMK2G | 0.33122187 |
| 111 | ALK | 0.33030669 |
| 112 | PDK2 | 0.32713884 |
| 113 | CHEK1 | 0.32699599 |
| 114 | CDK4 | 0.32661349 |
| 115 | MAP3K11 | 0.32582217 |
| 116 | BRSK2 | 0.32363535 |
| 117 | CASK | 0.32167589 |
| 118 | MUSK | 0.32035258 |
| 119 | PLK3 | 0.31955978 |
| 120 | ATM | 0.31684689 |
| 121 | FGFR1 | 0.31245788 |
| 122 | AURKA | 0.31147415 |
| 123 | STK4 | 0.30101280 |
| 124 | CSNK1A1 | 0.29961880 |
| 125 | PDGFRA | 0.29361752 |
| 126 | CAMK2D | 0.29156323 |
| 127 | DAPK1 | 0.28862708 |
| 128 | RET | 0.28318453 |
| 129 | LRRK2 | 0.28308213 |
| 130 | STK38 | 0.27243447 |
| 131 | RPS6KB1 | 0.25020618 |
| 132 | ICK | 0.24696062 |
| 133 | SRC | 0.22510505 |
| 134 | CAMK1D | 0.21617549 |
| 135 | MAPK11 | 0.20492687 |
| 136 | YES1 | 0.20378371 |
| 137 | ILK | 0.18919806 |
| 138 | VRK2 | 0.18167875 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.28751488 |
| 2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.20196341 |
| 3 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.95927355 |
| 4 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.76229450 |
| 5 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.62497909 |
| 6 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.46900646 |
| 7 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.44167571 |
| 8 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.34431289 |
| 9 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.17503114 |
| 10 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.15339527 |
| 11 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.12500838 |
| 12 | Histidine metabolism_Homo sapiens_hsa00340 | 2.01627552 |
| 13 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.96201232 |
| 14 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.94305770 |
| 15 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.89784539 |
| 16 | Retinol metabolism_Homo sapiens_hsa00830 | 1.81137524 |
| 17 | Mineral absorption_Homo sapiens_hsa04978 | 1.79521938 |
| 18 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.73960965 |
| 19 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.70952715 |
| 20 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.67752307 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.63345943 |
| 22 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.58720733 |
| 23 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.55509532 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.53461020 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53143173 |
| 26 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.52977972 |
| 27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.52496649 |
| 28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.49335648 |
| 29 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.47165279 |
| 30 | Bile secretion_Homo sapiens_hsa04976 | 1.42516401 |
| 31 | Galactose metabolism_Homo sapiens_hsa00052 | 1.41170313 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.36569936 |
| 33 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.35180276 |
| 34 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.30455209 |
| 35 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.30414711 |
| 36 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.29098565 |
| 37 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.28794552 |
| 38 | ABC transporters_Homo sapiens_hsa02010 | 1.27044749 |
| 39 | Peroxisome_Homo sapiens_hsa04146 | 1.26836147 |
| 40 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.23110502 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.23036083 |
| 42 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.19544815 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.19088503 |
| 44 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.18083461 |
| 45 | * Tight junction_Homo sapiens_hsa04530 | 1.14907216 |
| 46 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.13362299 |
| 47 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.12685826 |
| 48 | Sulfur relay system_Homo sapiens_hsa04122 | 1.11661929 |
| 49 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.10514192 |
| 50 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.08914104 |
| 51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.06362989 |
| 52 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.05692541 |
| 53 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.05561333 |
| 54 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.03773950 |
| 55 | Adherens junction_Homo sapiens_hsa04520 | 1.00316610 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.99781824 |
| 57 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.99272507 |
| 58 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.98764210 |
| 59 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.94566182 |
| 60 | Lysine degradation_Homo sapiens_hsa00310 | 0.92421582 |
| 61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.90685440 |
| 62 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.85959115 |
| 63 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.85813407 |
| 64 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.82433793 |
| 65 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.78743645 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.78593302 |
| 67 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.78288075 |
| 68 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.75637197 |
| 69 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.74894991 |
| 70 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.74536980 |
| 71 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74473833 |
| 72 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.73953804 |
| 73 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.67702139 |
| 74 | Thyroid cancer_Homo sapiens_hsa05216 | 0.66266496 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.63796037 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.62219796 |
| 77 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57675422 |
| 78 | Bladder cancer_Homo sapiens_hsa05219 | 0.55984020 |
| 79 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.52898513 |
| 80 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.52489179 |
| 81 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.50479028 |
| 82 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.49537411 |
| 83 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.48595804 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45982605 |
| 85 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.44972224 |
| 86 | Metabolic pathways_Homo sapiens_hsa01100 | 0.44703267 |
| 87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.44665411 |
| 88 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.44048103 |
| 89 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.43032799 |
| 90 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.42319955 |
| 91 | Other glycan degradation_Homo sapiens_hsa00511 | 0.39346951 |
| 92 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.39206574 |
| 93 | RNA transport_Homo sapiens_hsa03013 | 0.39125127 |
| 94 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.39038090 |
| 95 | Circadian rhythm_Homo sapiens_hsa04710 | 0.39036437 |
| 96 | Hepatitis C_Homo sapiens_hsa05160 | 0.38428658 |
| 97 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.37965893 |
| 98 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.37513351 |
| 99 | Protein export_Homo sapiens_hsa03060 | 0.34537484 |
| 100 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.34485486 |
| 101 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.33636294 |
| 102 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.32545078 |
| 103 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.31194856 |
| 104 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.28851193 |
| 105 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.28691724 |
| 106 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.27317821 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25929536 |
| 108 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.25040461 |
| 109 | Insulin resistance_Homo sapiens_hsa04931 | 0.22652182 |
| 110 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.21333774 |
| 111 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.16925562 |
| 112 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.12666498 |
| 113 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.09137576 |
| 114 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.06834884 |
| 115 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.05460959 |
| 116 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.05419468 |

