CGNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)5.16317927
2lysine metabolic process (GO:0006553)5.16317927
3L-phenylalanine catabolic process (GO:0006559)4.87257241
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87257241
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.77926598
6L-phenylalanine metabolic process (GO:0006558)4.77926598
7cysteine metabolic process (GO:0006534)4.75410723
8glyoxylate metabolic process (GO:0046487)4.67446373
9regulation of posttranscriptional gene silencing (GO:0060147)4.58200374
10regulation of gene silencing by miRNA (GO:0060964)4.58200374
11regulation of gene silencing by RNA (GO:0060966)4.58200374
12aromatic amino acid family catabolic process (GO:0009074)4.43196909
13complement activation, alternative pathway (GO:0006957)4.34439606
14alpha-linolenic acid metabolic process (GO:0036109)4.30644578
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29505245
16regulation of cardioblast differentiation (GO:0051890)4.27527881
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.14405037
18sulfur amino acid catabolic process (GO:0000098)4.14111443
19gap junction assembly (GO:0016264)4.12681176
20tryptophan catabolic process (GO:0006569)4.05190341
21indole-containing compound catabolic process (GO:0042436)4.05190341
22indolalkylamine catabolic process (GO:0046218)4.05190341
23kynurenine metabolic process (GO:0070189)4.03745650
24urate metabolic process (GO:0046415)4.00083802
25homocysteine metabolic process (GO:0050667)3.99436251
26protein carboxylation (GO:0018214)3.99213388
27peptidyl-glutamic acid carboxylation (GO:0017187)3.99213388
28amino-acid betaine metabolic process (GO:0006577)3.92689465
29paraxial mesoderm development (GO:0048339)3.91889171
30tryptophan metabolic process (GO:0006568)3.90650103
31serine family amino acid catabolic process (GO:0009071)3.89341861
32drug transmembrane transport (GO:0006855)3.87497601
33regulation of protein activation cascade (GO:2000257)3.80397943
34valine metabolic process (GO:0006573)3.72389679
35fatty acid beta-oxidation (GO:0006635)3.72080755
36regulation of complement activation (GO:0030449)3.71528195
37bile acid biosynthetic process (GO:0006699)3.69812968
38response to mercury ion (GO:0046689)3.68636723
39positive regulation of fatty acid beta-oxidation (GO:0032000)3.67525949
40cardiac myofibril assembly (GO:0055003)3.66687540
41blood coagulation, intrinsic pathway (GO:0007597)3.66572231
42acetyl-CoA metabolic process (GO:0006084)3.61096488
43negative regulation of fibrinolysis (GO:0051918)3.58655147
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56455143
45urea cycle (GO:0000050)3.54431564
46urea metabolic process (GO:0019627)3.54431564
47fatty acid oxidation (GO:0019395)3.53501767
482-oxoglutarate metabolic process (GO:0006103)3.49072970
49negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.47310578
50aspartate family amino acid catabolic process (GO:0009068)3.47252036
51lipid oxidation (GO:0034440)3.46892857
52short-chain fatty acid metabolic process (GO:0046459)3.45375997
53regulation of plasminogen activation (GO:0010755)3.43281798
54fatty acid transmembrane transport (GO:1902001)3.42625956
55cellular modified amino acid catabolic process (GO:0042219)3.38892074
56drug catabolic process (GO:0042737)3.33974016
574-hydroxyproline metabolic process (GO:0019471)3.33860007
58ethanol oxidation (GO:0006069)3.33672780
59regulation of fatty acid beta-oxidation (GO:0031998)3.32742258
60omega-hydroxylase P450 pathway (GO:0097267)3.32497908
61glucuronate metabolic process (GO:0019585)3.32252028
62uronic acid metabolic process (GO:0006063)3.32252028
63alpha-amino acid catabolic process (GO:1901606)3.31168205
64glycine metabolic process (GO:0006544)3.30022962
65carnitine metabolic process (GO:0009437)3.25469464
66fatty acid catabolic process (GO:0009062)3.24382284
67positive regulation of SMAD protein import into nucleus (GO:0060391)3.23278554
68quaternary ammonium group transport (GO:0015697)3.23052279
69nitrogen cycle metabolic process (GO:0071941)3.22773891
70plasma lipoprotein particle clearance (GO:0034381)3.21635817
71biotin metabolic process (GO:0006768)3.21192316
72carnitine shuttle (GO:0006853)3.18538609
73cellular amino acid catabolic process (GO:0009063)3.17997370
74tricarboxylic acid metabolic process (GO:0072350)3.17981604
75negative regulation of hemostasis (GO:1900047)3.17796014
76negative regulation of blood coagulation (GO:0030195)3.17796014
77regulation of cholesterol homeostasis (GO:2000188)3.17656379
78cellular ketone body metabolic process (GO:0046950)3.17364678
79positive regulation of fatty acid oxidation (GO:0046321)3.16785305
80low-density lipoprotein particle clearance (GO:0034383)3.15484473
81regulation of fibrinolysis (GO:0051917)3.15117443
82drug transport (GO:0015893)3.13576351
83aldehyde catabolic process (GO:0046185)3.13318194
84aromatic amino acid family metabolic process (GO:0009072)3.13286848
85cell communication by electrical coupling (GO:0010644)3.12317166
86regulation of triglyceride catabolic process (GO:0010896)3.12162830
87amino-acid betaine transport (GO:0015838)3.12115994
88carnitine transport (GO:0015879)3.12115994
89branched-chain amino acid metabolic process (GO:0009081)3.10795190
90monocarboxylic acid catabolic process (GO:0072329)3.10220693
91embryonic retina morphogenesis in camera-type eye (GO:0060059)3.09730701
92bile acid metabolic process (GO:0008206)3.08061200
93serine family amino acid metabolic process (GO:0009069)3.07739250
94positive regulation of catenin import into nucleus (GO:0035413)3.03837439
95positive regulation of lipid catabolic process (GO:0050996)3.03200013
96glutamate metabolic process (GO:0006536)3.02854792
97myofibril assembly (GO:0030239)3.02436371
98apoptotic cell clearance (GO:0043277)3.02184412
99branched-chain amino acid catabolic process (GO:0009083)3.01112810
100notochord development (GO:0030903)2.99354223
101regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.98882885
102ethanol metabolic process (GO:0006067)2.98301542
103negative regulation of coagulation (GO:0050819)2.97260174
104organic acid catabolic process (GO:0016054)2.96276727
105carboxylic acid catabolic process (GO:0046395)2.96276727
106exogenous drug catabolic process (GO:0042738)2.96021185
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95965025
108phospholipid homeostasis (GO:0055091)2.95881603
109triglyceride homeostasis (GO:0070328)2.95698288
110acylglycerol homeostasis (GO:0055090)2.95698288
111tyrosine metabolic process (GO:0006570)2.95236596
112high-density lipoprotein particle remodeling (GO:0034375)2.93508674
113negative regulation of wound healing (GO:0061045)2.93197521
114regulation of apoptotic cell clearance (GO:2000425)2.92419471
115fibrinolysis (GO:0042730)2.89028738
116phosphate ion transport (GO:0006817)2.88847129
117benzene-containing compound metabolic process (GO:0042537)2.88618880
118phosphate ion transmembrane transport (GO:0035435)2.88383357
119regulation of bile acid biosynthetic process (GO:0070857)2.88143604
120pre-miRNA processing (GO:0031054)2.87462074
121striated muscle hypertrophy (GO:0014897)2.87102257
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86677709
123negative regulation of cholesterol transport (GO:0032375)2.86180318
124negative regulation of sterol transport (GO:0032372)2.86180318
125regulation of fatty acid oxidation (GO:0046320)2.85308514
126chemical homeostasis within a tissue (GO:0048875)2.83955530
127cellular glucuronidation (GO:0052695)2.81292180
128adult heart development (GO:0007512)2.80554047
129surfactant homeostasis (GO:0043129)2.79740268
130dicarboxylic acid biosynthetic process (GO:0043650)2.79186007
131heme transport (GO:0015886)2.77892971
132epoxygenase P450 pathway (GO:0019373)2.77845898
133anterior/posterior axis specification, embryo (GO:0008595)2.76674779
134reverse cholesterol transport (GO:0043691)2.76443366
135carnitine transmembrane transport (GO:1902603)2.76034879
136drug metabolic process (GO:0017144)2.76014507
137negative regulation of hormone biosynthetic process (GO:0032353)2.75261532
138cardiac muscle hypertrophy (GO:0003300)2.73830150
139regulation of SMAD protein import into nucleus (GO:0060390)2.72295577
140glomerular visceral epithelial cell development (GO:0072015)2.70112099
141lymphangiogenesis (GO:0001946)2.69545672
142mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.67516510
143embryonic foregut morphogenesis (GO:0048617)2.64023524
144regulation of hippo signaling (GO:0035330)2.61972638
145negative regulation of lipase activity (GO:0060192)2.58915567
146negative regulation of hormone metabolic process (GO:0032351)2.56148077
147negative regulation of protein activation cascade (GO:2000258)2.54279367
148oxidative demethylation (GO:0070989)2.53879963
149positive regulation of cardiac muscle cell proliferation (GO:0060045)2.53377585
150L-serine metabolic process (GO:0006563)2.52999928
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51152807
152prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.49146273
153branching involved in salivary gland morphogenesis (GO:0060445)2.48835985
154muscle hypertrophy (GO:0014896)2.48770349
155regulation of cell fate specification (GO:0042659)2.45212652
156serine family amino acid biosynthetic process (GO:0009070)2.43907826
157phenylpropanoid metabolic process (GO:0009698)2.42337882
158protein activation cascade (GO:0072376)2.41216911
159cell communication involved in cardiac conduction (GO:0086065)2.38796768
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37987771
161cardiac muscle cell development (GO:0055013)2.37214810
162artery development (GO:0060840)2.36473190
163atrial septum morphogenesis (GO:0060413)2.35802629
164atrioventricular valve morphogenesis (GO:0003181)2.34511685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.49492379
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.47669299
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.46464862
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.84902139
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.55311068
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.23552026
7CLOCK_20551151_ChIP-Seq_293T_Human3.20553658
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17541435
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13307435
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.09633684
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.82730569
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.72249672
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.58373401
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55689269
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.35180964
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29924507
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.23929989
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.23612640
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.13668789
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13272113
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12398611
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12398611
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12398611
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99416144
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98509561
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83695203
27* SMAD3_21741376_ChIP-Seq_HESCs_Human1.81657079
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79717373
29ZNF263_19887448_ChIP-Seq_K562_Human1.75411566
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70391034
31GBX2_23144817_ChIP-Seq_PC3_Human1.69884485
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66967674
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66169244
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.62562051
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60103418
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59900542
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57079998
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55875314
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55783003
40* EP300_21415370_ChIP-Seq_HL-1_Mouse1.55171486
41* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55018846
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.53333112
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52123334
44* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51133596
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50025633
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49759953
47SMAD4_21741376_ChIP-Seq_HESCs_Human1.48102419
48P300_19829295_ChIP-Seq_ESCs_Human1.44977149
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43578837
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43084999
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40780537
52GATA4_25053715_ChIP-Seq_YYC3_Human1.37833071
53* TBX20_22080862_ChIP-Seq_HEART_Mouse1.37179179
54* TBX20_22328084_ChIP-Seq_HEART_Mouse1.37179179
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.36812056
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.36220383
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35502661
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31637030
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31346955
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30736576
61SMAD4_21799915_ChIP-Seq_A2780_Human1.29212341
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28725030
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28710812
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28621009
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.28344032
66* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26294994
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.26077612
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25602309
69AR_21572438_ChIP-Seq_LNCaP_Human1.24663918
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24196615
71* SOX2_20726797_ChIP-Seq_SW620_Human1.23389607
72RACK7_27058665_Chip-Seq_MCF-7_Human1.23079731
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22589562
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22219765
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22219765
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21055331
77CJUN_26792858_Chip-Seq_BT549_Human1.19433454
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18458102
79* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18395830
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18032924
81* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17569958
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16390023
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15419780
84PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14212202
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14019348
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12199233
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12083181
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11370825
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11214350
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10853221
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10839787
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10839787
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10828912
94GATA6_25053715_ChIP-Seq_YYC3_Human1.09796829
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.09597435
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09303537
97* CDX2_20551321_ChIP-Seq_CACO-2_Human1.09070278
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08762006
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08118922
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07462486
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.06874838
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06710625
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05881701
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05763872
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05744763
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05679984
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.05188097
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03633944
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03246255
110TAF15_26573619_Chip-Seq_HEK293_Human1.02809031
111* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02655455
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02309380
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02270838
114STAT3_23295773_ChIP-Seq_U87_Human1.02236881
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02060716
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00190017
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00190017
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00071211
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98740313
120LXR_22292898_ChIP-Seq_THP-1_Human0.98513917
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98463741
122EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98208152
123RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98208152
124BCAT_22108803_ChIP-Seq_LS180_Human0.98096873
125* TCF4_23295773_ChIP-Seq_U87_Human0.98021096
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98015381
127ATF3_27146783_Chip-Seq_COLON_Human0.97877821
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97857596
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.97322777
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96954712
131* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95633222
132* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95091537
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95017570
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95000522
135VDR_22108803_ChIP-Seq_LS180_Human0.94697914
136* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94506658
137AR_21909140_ChIP-Seq_LNCAP_Human0.93132362
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92416596
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91278025
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88974634
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88845085
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.87439531
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87288359
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87257963
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.85107376
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84998549
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83237558
148TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83155173
149P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83051926
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80744749
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79295826
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78498070
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78246949
154GATA1_19941826_ChIP-Seq_K562_Human0.77011969
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76512823
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.75922102
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75493860
158* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74851801
159AHR_22903824_ChIP-Seq_MCF-7_Human0.74848468
160GATA2_19941826_ChIP-Seq_K562_Human0.74528657
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.73220245
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73012824
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72882313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.38112926
2MP0002139_abnormal_hepatobiliary_system5.33381023
3MP0003941_abnormal_skin_development4.47411277
4MP0005085_abnormal_gallbladder_physiolo3.79819642
5MP0005365_abnormal_bile_salt3.76775142
6MP0003252_abnormal_bile_duct3.05457850
7MP0003705_abnormal_hypodermis_morpholog2.97385123
8MP0003195_calcinosis2.89770117
9MP0008875_abnormal_xenobiotic_pharmacok2.86754846
10MP0005332_abnormal_amino_acid2.80380530
11MP0004272_abnormal_basement_membrane2.71682539
12MP0008438_abnormal_cutaneous_collagen2.52725825
13MP0003890_abnormal_embryonic-extraembry2.34789260
14MP0010329_abnormal_lipoprotein_level2.33645558
15MP0002138_abnormal_hepatobiliary_system2.33093408
16MP0004019_abnormal_vitamin_homeostasis2.30986791
17MP0010368_abnormal_lymphatic_system2.12954696
18MP0005083_abnormal_biliary_tract2.09278802
19MP0003567_abnormal_fetal_cardiomyocyte2.04894868
20MP0005670_abnormal_white_adipose2.04808100
21MP0003806_abnormal_nucleotide_metabolis2.04023887
22MP0009643_abnormal_urine_homeostasis1.97665252
23MP0003878_abnormal_ear_physiology1.94541467
24MP0005377_hearing/vestibular/ear_phenot1.94541467
25MP0001666_abnormal_nutrient_absorption1.77211582
26MP0010030_abnormal_orbit_morphology1.75488097
27MP0000566_synostosis1.73222108
28MP0001756_abnormal_urination1.66403953
29MP0002697_abnormal_eye_size1.65352136
30MP0003191_abnormal_cellular_cholesterol1.65270055
31MP0005275_abnormal_skin_tensile1.61630884
32MP0001958_emphysema1.59376768
33MP0009840_abnormal_foam_cell1.59288521
34MP0009697_abnormal_copulation1.59035701
35MP0003937_abnormal_limbs/digits/tail_de1.56779729
36MP0004215_abnormal_myocardial_fiber1.54535724
37MP0002118_abnormal_lipid_homeostasis1.52578516
38MP0003566_abnormal_cell_adhesion1.52455672
39MP0005666_abnormal_adipose_tissue1.48991619
40MP0009672_abnormal_birth_weight1.46739106
41MP0004084_abnormal_cardiac_muscle1.46079126
42MP0000609_abnormal_liver_physiology1.45258689
43MP0004043_abnormal_pH_regulation1.44533424
44MP0010234_abnormal_vibrissa_follicle1.43884307
45MP0005319_abnormal_enzyme/_coenzyme1.43619423
46MP0002102_abnormal_ear_morphology1.42006002
47MP0002136_abnormal_kidney_physiology1.36859938
48MP0003119_abnormal_digestive_system1.32992705
49MP0004130_abnormal_muscle_cell1.31812175
50MP0001879_abnormal_lymphatic_vessel1.26960291
51MP0009384_cardiac_valve_regurgitation1.26402078
52MP0000537_abnormal_urethra_morphology1.26076720
53MP0003300_gastrointestinal_ulcer1.25914414
54MP0005058_abnormal_lysosome_morphology1.23139982
55MP0009053_abnormal_anal_canal1.21200898
56MP0005257_abnormal_intraocular_pressure1.20396058
57MP0005451_abnormal_body_composition1.19739563
58MP0005167_abnormal_blood-brain_barrier1.13885018
59MP0002168_other_aberrant_phenotype1.12724830
60MP0004085_abnormal_heartbeat1.12372934
61MP0006138_congestive_heart_failure1.10748889
62MP0005584_abnormal_enzyme/coenzyme_acti1.10508937
63MP0003186_abnormal_redox_activity1.07337367
64MP0004185_abnormal_adipocyte_glucose1.06281636
65MP0005636_abnormal_mineral_homeostasis1.06033129
66MP0000462_abnormal_digestive_system1.04898787
67MP0005187_abnormal_penis_morphology1.04684241
68MP0001765_abnormal_ion_homeostasis1.03545684
69MP0002925_abnormal_cardiovascular_devel1.02436900
70MP0003984_embryonic_growth_retardation1.01805524
71MP0002127_abnormal_cardiovascular_syste1.01427588
72MP0002088_abnormal_embryonic_growth/wei1.01335218
73MP0003279_aneurysm1.00127589
74MP0005084_abnormal_gallbladder_morpholo0.99021548
75MP0005375_adipose_tissue_phenotype0.98481850
76MP0000598_abnormal_liver_morphology0.97733876
77MP0005623_abnormal_meninges_morphology0.97588244
78MP0002249_abnormal_larynx_morphology0.97073912
79MP0002295_abnormal_pulmonary_circulatio0.96295475
80MP0002254_reproductive_system_inflammat0.95186230
81MP0002084_abnormal_developmental_patter0.93876327
82MP0005620_abnormal_muscle_contractility0.92828206
83MP0001293_anophthalmia0.92693846
84MP0003137_abnormal_impulse_conducting0.92231513
85MP0002971_abnormal_brown_adipose0.91268767
86MP0009250_abnormal_appendicular_skeleto0.90527603
87MP0003136_yellow_coat_color0.89795478
88MP0005023_abnormal_wound_healing0.88987753
89MP0005408_hypopigmentation0.88078957
90MP0002928_abnormal_bile_duct0.88027952
91MP0009703_decreased_birth_body0.87467871
92MP0003385_abnormal_body_wall0.87368118
93MP0000767_abnormal_smooth_muscle0.87198116
94MP0005380_embryogenesis_phenotype0.87175061
95MP0001672_abnormal_embryogenesis/_devel0.87175061
96MP0000266_abnormal_heart_morphology0.86233877
97MP0005330_cardiomyopathy0.85916380
98MP0004036_abnormal_muscle_relaxation0.85646728
99MP0002233_abnormal_nose_morphology0.84509309
100MP0010630_abnormal_cardiac_muscle0.83966560
101MP0003935_abnormal_craniofacial_develop0.83010876
102MP0001177_atelectasis0.82508125
103MP0002896_abnormal_bone_mineralization0.82050950
104MP0008775_abnormal_heart_ventricle0.81697457
105MP0002135_abnormal_kidney_morphology0.81492434
106MP0001286_abnormal_eye_development0.80144170
107MP0004264_abnormal_extraembryonic_tissu0.79723670
108MP0001299_abnormal_eye_distance/0.79577322
109MP0000762_abnormal_tongue_morphology0.77919012
110MP0000432_abnormal_head_morphology0.77512576
111MP0005385_cardiovascular_system_phenoty0.76419916
112MP0001544_abnormal_cardiovascular_syste0.76419916
113MP0003942_abnormal_urinary_system0.76123447
114MP0000428_abnormal_craniofacial_morphol0.75693527
115MP0004133_heterotaxia0.75257622
116MP0002282_abnormal_trachea_morphology0.75092904
117MP0001661_extended_life_span0.74965245
118MP0001730_embryonic_growth_arrest0.74741504
119MP0002060_abnormal_skin_morphology0.74274558
120MP0005248_abnormal_Harderian_gland0.73195746
121MP0000230_abnormal_systemic_arterial0.73084559
122MP0002108_abnormal_muscle_morphology0.71010488
123MP0002085_abnormal_embryonic_tissue0.70475046
124MP0006054_spinal_hemorrhage0.70191158
125MP0002972_abnormal_cardiac_muscle0.70076161
126MP0003868_abnormal_feces_composition0.70052662
127MP0002128_abnormal_blood_circulation0.69958079
128MP0005220_abnormal_exocrine_pancreas0.69428806
129MP0005503_abnormal_tendon_morphology0.68924893
130MP0002086_abnormal_extraembryonic_tissu0.68467628
131MP0002796_impaired_skin_barrier0.67992652
132MP0003115_abnormal_respiratory_system0.67342100
133MP0010352_gastrointestinal_tract_polyps0.66090241
134MP0000534_abnormal_ureter_morphology0.64744386
135MP0004782_abnormal_surfactant_physiolog0.64686569
136MP0000249_abnormal_blood_vessel0.63531159
137MP0009764_decreased_sensitivity_to0.63281353
138MP0005395_other_phenotype0.62834031
139MP0002837_dystrophic_cardiac_calcinosis0.62641348
140MP0004087_abnormal_muscle_fiber0.62398709
141MP0009642_abnormal_blood_homeostasis0.61099503
142MP0001915_intracranial_hemorrhage0.60935222
143MP0003091_abnormal_cell_migration0.60639261
144MP0001614_abnormal_blood_vessel0.60273819
145MP0009763_increased_sensitivity_to0.59817761
146MP0008961_abnormal_basal_metabolism0.59672432
147MP0001881_abnormal_mammary_gland0.56648163
148MP0005165_increased_susceptibility_to0.56335126

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.93578243
2Hyperglycinuria (HP:0003108)4.23475048
3Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99381566
4Gout (HP:0001997)3.97245798
5Xanthomatosis (HP:0000991)3.94376783
6Intrahepatic cholestasis (HP:0001406)3.84117601
7Complement deficiency (HP:0004431)3.75287688
8Abnormality of glycine metabolism (HP:0010895)3.72305892
9Abnormality of serine family amino acid metabolism (HP:0010894)3.72305892
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.65510419
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61704308
12Hypokalemic alkalosis (HP:0001949)3.60532810
13Hyperammonemia (HP:0001987)3.44278816
14Ketosis (HP:0001946)3.38501638
15Hyperglycinemia (HP:0002154)3.35711075
16Abnormality of fatty-acid metabolism (HP:0004359)3.34669146
17Hyperactive renin-angiotensin system (HP:0000841)3.22666391
18Vascular calcification (HP:0004934)3.22278327
19Partial duplication of thumb phalanx (HP:0009944)3.20440398
20Aplasia involving bones of the upper limbs (HP:0009823)3.19136692
21Aplasia of the phalanges of the hand (HP:0009802)3.19136692
22Aplasia involving bones of the extremities (HP:0009825)3.19136692
23Cardiovascular calcification (HP:0011915)3.16490624
24Abnormality of purine metabolism (HP:0004352)3.15499057
25Hypoglycemic coma (HP:0001325)3.12370013
26Choanal stenosis (HP:0000452)3.06828976
27Abnormality of the common coagulation pathway (HP:0010990)3.04468359
28Ketoacidosis (HP:0001993)3.03599015
29Esophageal varix (HP:0002040)3.03297217
30Metabolic alkalosis (HP:0200114)3.01895132
31Abnormality of chloride homeostasis (HP:0011422)3.00306830
32Prolonged partial thromboplastin time (HP:0003645)2.93633878
33Hydroxyprolinuria (HP:0003080)2.90651161
34Abnormality of proline metabolism (HP:0010907)2.90651161
35Abnormality of complement system (HP:0005339)2.90107444
36Systemic lupus erythematosus (HP:0002725)2.87206256
37Proximal tubulopathy (HP:0000114)2.85298063
38Ventricular tachycardia (HP:0004756)2.83910201
39Focal segmental glomerulosclerosis (HP:0000097)2.83508671
40Increased circulating renin level (HP:0000848)2.81253063
41Glomerulosclerosis (HP:0000096)2.79143317
42Bronchomalacia (HP:0002780)2.78558460
43Partial duplication of the phalanx of hand (HP:0009999)2.77818756
44Alkalosis (HP:0001948)2.77106788
45Lymphangioma (HP:0100764)2.74735597
46Increased purine levels (HP:0004368)2.72499020
47Hyperuricemia (HP:0002149)2.72499020
48Nephritis (HP:0000123)2.70767960
49Hyperlipoproteinemia (HP:0010980)2.68669680
50Conjugated hyperbilirubinemia (HP:0002908)2.65850032
51Hepatocellular carcinoma (HP:0001402)2.65027244
52Joint hemorrhage (HP:0005261)2.64777031
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.64197098
54Osteomalacia (HP:0002749)2.63798274
55Hepatoblastoma (HP:0002884)2.63684945
56Abnormality of nucleobase metabolism (HP:0010932)2.61752470
57Glomerulonephritis (HP:0000099)2.61507283
58Abnormal urine output (HP:0012590)2.61166831
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58854505
60Myocardial infarction (HP:0001658)2.55691471
61Polyuria (HP:0000103)2.55429330
62Abnormality of renal excretion (HP:0011036)2.53916118
63Neonatal hypoglycemia (HP:0001998)2.52908801
64Atrioventricular block (HP:0001678)2.50126893
65Right ventricular cardiomyopathy (HP:0011663)2.48711523
66Hypoalphalipoproteinemia (HP:0003233)2.44527036
67Hypobetalipoproteinemia (HP:0003563)2.44043495
68Renal salt wasting (HP:0000127)2.42169207
69Preaxial foot polydactyly (HP:0001841)2.41873545
70Epidermoid cyst (HP:0200040)2.40593577
71Generalized aminoaciduria (HP:0002909)2.38091424
72Patent foramen ovale (HP:0001655)2.35472208
73Vitreoretinal degeneration (HP:0000655)2.33883750
74Delayed CNS myelination (HP:0002188)2.33446650
75Absent eyebrow (HP:0002223)2.33320927
76Abnormality of the lacrimal duct (HP:0011481)2.31630073
77Hypolipoproteinemia (HP:0010981)2.26483352
78Dicarboxylic aciduria (HP:0003215)2.20833168
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20833168
80Skull defect (HP:0001362)2.20012609
81Short hallux (HP:0010109)2.19650599
82Abnormality of the intrinsic pathway (HP:0010989)2.18432285
83Cutaneous finger syndactyly (HP:0010554)2.17978423
84Heart block (HP:0012722)2.17287777
85Fat malabsorption (HP:0002630)2.17226058
86Myelomeningocele (HP:0002475)2.17092694
87Spastic diplegia (HP:0001264)2.16993237
88Hemangiomatosis (HP:0007461)2.14906449
89Hemorrhage of the eye (HP:0011885)2.14889679
90Cerebral aneurysm (HP:0004944)2.13201271
91Hypomagnesemia (HP:0002917)2.13108636
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11156513
93Malnutrition (HP:0004395)2.10529706
94Hyperaldosteronism (HP:0000859)2.08902211
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07594361
96Tubulointerstitial fibrosis (HP:0005576)2.06696806
97Protrusio acetabuli (HP:0003179)2.06487314
98Abnormal cartilage morphology (HP:0002763)2.06136709
99Cutaneous syndactyly (HP:0012725)2.05347500
100Chondrocalcinosis (HP:0000934)2.05221547
101Bifid scrotum (HP:0000048)2.04976759
102Abnormality of the nasolacrimal system (HP:0000614)2.04536217
103Broad metatarsal (HP:0001783)2.03680329
104Coronal craniosynostosis (HP:0004440)2.01317658
105Hypercholesterolemia (HP:0003124)2.00661372
106Abnormality of urine glucose concentration (HP:0011016)2.00051835
107Glycosuria (HP:0003076)2.00051835
108Mitral valve prolapse (HP:0001634)1.98690824
109Sudden death (HP:0001699)1.98534386
110Aortic aneurysm (HP:0004942)1.98215305
111Shallow orbits (HP:0000586)1.97046875
112Metabolic acidosis (HP:0001942)1.96559536
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.93581219
114Abnormal atrioventricular conduction (HP:0005150)1.93287974
115Renal tubular acidosis (HP:0001947)1.92559256
116Abnormal pancreas size (HP:0012094)1.92353616
117Nephrolithiasis (HP:0000787)1.91201149
118Enlarged kidneys (HP:0000105)1.91080147
119Hypokalemia (HP:0002900)1.91024520
120Mixed hearing impairment (HP:0000410)1.90932488
121Visceral angiomatosis (HP:0100761)1.90918684
122Skin nodule (HP:0200036)1.90018133
123Neonatal death (HP:0003811)1.88032559
124Potter facies (HP:0002009)1.87192613
125Facial shape deformation (HP:0011334)1.87192613
126Abnormality of Sharpey fibers (HP:0100685)1.86609573
127Spontaneous abortion (HP:0005268)1.85959115
128Abnormality of the middle phalanges of the toes (HP:0010183)1.85441087
129Atrial fibrillation (HP:0005110)1.84596396
130Abnormality of potassium homeostasis (HP:0011042)1.83943251
131Midline defect of the nose (HP:0004122)1.83702941
132Alacrima (HP:0000522)1.82912634
133Aneurysm (HP:0002617)1.82822510
134Abnormality of serum amino acid levels (HP:0003112)1.81342098
135Bilateral microphthalmos (HP:0007633)1.80816578
136Bicornuate uterus (HP:0000813)1.80699243
137Turricephaly (HP:0000262)1.80347653
138Abnormality of renin-angiotensin system (HP:0000847)1.80159087
139Bundle branch block (HP:0011710)1.79917228
140Absent eyelashes (HP:0000561)1.79589853
141Vomiting (HP:0002013)1.79268022
142Late onset (HP:0003584)1.79154387
143Myoglobinuria (HP:0002913)1.78187305
144Rickets (HP:0002748)1.78101334
145Tetany (HP:0001281)1.76524461
146Duplication of thumb phalanx (HP:0009942)1.74972672
147Abnormality of the salivary glands (HP:0010286)1.73744478
148Hypoglycemic seizures (HP:0002173)1.70512964
149Stenosis of the external auditory canal (HP:0000402)1.64899440
150Cupped ear (HP:0000378)1.62628601
151Abnormality of the fingertips (HP:0001211)1.62403059
152Abnormality of incisor morphology (HP:0011063)1.59685405
153Tracheal stenosis (HP:0002777)1.59456628
154Limited hip movement (HP:0008800)1.58900906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.16076245
2WNK43.43916906
3BCKDK3.23920202
4RIPK13.17117194
5PKN22.93723632
6SIK12.71879845
7WNK32.55592428
8TIE12.47054377
9LATS12.43759238
10ERN12.37909686
11MST1R2.30027111
12TNIK2.24272725
13EPHA22.07226530
14OXSR12.03826393
15PTK62.01948043
16NLK1.98770905
17TTN1.83530642
18FGFR41.80937800
19STK38L1.80435679
20TGFBR21.78412811
21CAMK1D1.73511021
22MET1.73396538
23EPHB21.68501050
24EEF2K1.66632721
25KDR1.58513514
26PDGFRA1.57988107
27STK391.57187254
28MYLK1.52209791
29FER1.45862882
30PTK21.41320625
31LRRK21.36535752
32MKNK21.34131433
33PDK21.32405670
34EPHB11.27887941
35CAMK1G1.26671793
36PDK31.25708141
37PDK41.25708141
38FLT31.25180245
39PAK41.20557357
40CASK1.16564010
41BMX1.14645728
42CDK121.13953489
43MAP3K31.12898373
44LMTK21.11880802
45STK31.06223919
46NEK91.05590570
47TAF11.05135090
48TTK1.02289127
49BMPR1B1.01516767
50MAP3K90.99292832
51FRK0.95774318
52PLK40.94999531
53LATS20.93259636
54ACVR1B0.92994518
55STK240.92296881
56INSRR0.89350628
57ERBB40.88104915
58DDR20.87985650
59MKNK10.87891875
60TAOK30.87823316
61STK380.85003550
62GSK3A0.82047780
63BCR0.81233275
64PTK2B0.80696658
65PRKAA20.80489570
66MAP2K30.80432690
67STK100.80414149
68PAK20.78002389
69WNK10.77325061
70SGK30.77106929
71MAP3K70.76239615
72FGFR10.74337187
73ABL20.72732581
74NTRK30.70726114
75MTOR0.70564973
76PIK3CA0.67679256
77FGFR20.66556820
78PDGFRB0.65318913
79OBSCN0.65256550
80CDK60.64871657
81PRKCE0.64746486
82TYRO30.63171051
83NEK10.61235767
84ERBB20.61199496
85PINK10.61098467
86FGFR30.60582719
87DAPK20.60108942
88TRPM70.54615511
89PAK30.54591562
90TSSK60.54141286
91RET0.53675068
92CDC70.53385877
93PNCK0.53194511
94DMPK0.52663599
95ROCK10.52552106
96MAP2K10.52549583
97SGK2230.51921368
98SGK4940.51921368
99CSNK1G10.50201446
100JAK10.50057930
101MELK0.48864044
102SGK20.48426477
103PDPK10.48108739
104MAP3K100.47903337
105NTRK10.47719964
106EGFR0.46822990
107PRKG20.45871341
108MAPK70.45589070
109PRKD10.44651756
110JAK20.44015324
111PIK3CG0.43085199
112PLK30.42639830
113CAMK10.42636373
114IGF1R0.42332980
115DYRK1B0.42046640
116MARK20.41938251
117CSNK1E0.41450011
118TGFBR10.40660405
119PRKCH0.40143845
120PRKAA10.40094894
121BRSK20.39859325
122MAP3K20.39622981
123PRKD30.39135053
124TYK20.38733341
125CAMK40.38585960
126SGK10.37286590
127AKT30.37012370
128TBK10.36866623
129ZAK0.36364964
130MAP2K20.36026152
131BRD40.35727837
132MAPK110.35341495
133MAPK100.34879573
134EPHA30.34831155
135MST40.34545861
136CSK0.34498720
137ALK0.34351850
138PRKCZ0.33432259
139ILK0.33175712
140PRKACG0.33076138
141PRKDC0.31444400
142RPS6KA30.31182706
143AKT20.30910335
144ICK0.30880794

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.04819082
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00677719
3Nitrogen metabolism_Homo sapiens_hsa009102.93028466
4Fatty acid degradation_Homo sapiens_hsa000712.85267467
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79546535
6Propanoate metabolism_Homo sapiens_hsa006402.77060807
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73266398
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72155658
9Tryptophan metabolism_Homo sapiens_hsa003802.38136525
10Arginine biosynthesis_Homo sapiens_hsa002202.38069612
11Complement and coagulation cascades_Homo sapiens_hsa046102.32852260
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28621951
13PPAR signaling pathway_Homo sapiens_hsa033202.18687885
14Fatty acid metabolism_Homo sapiens_hsa012122.16656202
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13657991
16Butanoate metabolism_Homo sapiens_hsa006502.11330804
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02662067
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96294912
19Peroxisome_Homo sapiens_hsa041461.89458840
20beta-Alanine metabolism_Homo sapiens_hsa004101.82663822
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79607749
22Pyruvate metabolism_Homo sapiens_hsa006201.79265050
23Staphylococcus aureus infection_Homo sapiens_hsa051501.69975000
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65684492
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64444410
26Bile secretion_Homo sapiens_hsa049761.60331634
27Phenylalanine metabolism_Homo sapiens_hsa003601.57832422
28Histidine metabolism_Homo sapiens_hsa003401.53753187
29Carbon metabolism_Homo sapiens_hsa012001.52847214
30Caffeine metabolism_Homo sapiens_hsa002321.50358922
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42092274
32Chemical carcinogenesis_Homo sapiens_hsa052041.41687344
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39996509
34Starch and sucrose metabolism_Homo sapiens_hsa005001.33245154
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24929654
36Lysine degradation_Homo sapiens_hsa003101.24800071
37Linoleic acid metabolism_Homo sapiens_hsa005911.23939233
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.17735551
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17154292
40Selenocompound metabolism_Homo sapiens_hsa004501.14325973
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.13838930
42Biosynthesis of amino acids_Homo sapiens_hsa012301.13278990
43Tyrosine metabolism_Homo sapiens_hsa003501.10227253
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10217617
45Vitamin B6 metabolism_Homo sapiens_hsa007501.07276286
46Retinol metabolism_Homo sapiens_hsa008301.06796194
47Vitamin digestion and absorption_Homo sapiens_hsa049771.06386158
48Sulfur metabolism_Homo sapiens_hsa009201.04181052
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.01029371
50Arginine and proline metabolism_Homo sapiens_hsa003300.96668138
51ECM-receptor interaction_Homo sapiens_hsa045120.96296162
52Fat digestion and absorption_Homo sapiens_hsa049750.94690022
53Fatty acid biosynthesis_Homo sapiens_hsa000610.88916384
54Glycerolipid metabolism_Homo sapiens_hsa005610.88477956
55Arachidonic acid metabolism_Homo sapiens_hsa005900.87360709
56ABC transporters_Homo sapiens_hsa020100.83742156
57Fatty acid elongation_Homo sapiens_hsa000620.83635240
58Circadian rhythm_Homo sapiens_hsa047100.82635221
59Glutathione metabolism_Homo sapiens_hsa004800.79173772
60Protein digestion and absorption_Homo sapiens_hsa049740.79125402
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.75657338
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72916622
63Insulin resistance_Homo sapiens_hsa049310.67957274
64Focal adhesion_Homo sapiens_hsa045100.65290641
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64400534
66Basal cell carcinoma_Homo sapiens_hsa052170.63904182
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.63588680
68Adherens junction_Homo sapiens_hsa045200.59146550
69Folate biosynthesis_Homo sapiens_hsa007900.58236418
70Prion diseases_Homo sapiens_hsa050200.56548060
71Amoebiasis_Homo sapiens_hsa051460.56467866
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55023952
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.52168875
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51940537
75Pentose phosphate pathway_Homo sapiens_hsa000300.51749902
76Other glycan degradation_Homo sapiens_hsa005110.49421108
77Small cell lung cancer_Homo sapiens_hsa052220.48468175
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.48008175
79Wnt signaling pathway_Homo sapiens_hsa043100.47440741
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46342931
81Serotonergic synapse_Homo sapiens_hsa047260.45804638
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42847071
83AMPK signaling pathway_Homo sapiens_hsa041520.41353818
84Proteoglycans in cancer_Homo sapiens_hsa052050.41053031
85Steroid biosynthesis_Homo sapiens_hsa001000.37678754
86Mineral absorption_Homo sapiens_hsa049780.36907875
87Fructose and mannose metabolism_Homo sapiens_hsa000510.35744710
88Hedgehog signaling pathway_Homo sapiens_hsa043400.34157364
89Lysosome_Homo sapiens_hsa041420.33703438
90Renin-angiotensin system_Homo sapiens_hsa046140.32190766
91Glucagon signaling pathway_Homo sapiens_hsa049220.31398295
92Bladder cancer_Homo sapiens_hsa052190.30528575
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.30316069
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.30297972
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.30166683
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29428391
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29345719
98Thyroid cancer_Homo sapiens_hsa052160.29247661
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28822255
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28409255
101Prostate cancer_Homo sapiens_hsa052150.27843983
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26460773
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26160115
104Tight junction_Homo sapiens_hsa045300.26023126
105Sulfur relay system_Homo sapiens_hsa041220.25849196
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25824792
107Dilated cardiomyopathy_Homo sapiens_hsa054140.25008599
108Metabolic pathways_Homo sapiens_hsa011000.24533349
109Ovarian steroidogenesis_Homo sapiens_hsa049130.23938861
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21398542
111Pancreatic secretion_Homo sapiens_hsa049720.21253268
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21099359
113One carbon pool by folate_Homo sapiens_hsa006700.20721482
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20469075
115Galactose metabolism_Homo sapiens_hsa000520.20061514
116MicroRNAs in cancer_Homo sapiens_hsa052060.20017282
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19965030
118Thyroid hormone synthesis_Homo sapiens_hsa049180.19420752
119Hippo signaling pathway_Homo sapiens_hsa043900.18272835
120Insulin signaling pathway_Homo sapiens_hsa049100.14113410
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14007561
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13757972
123TGF-beta signaling pathway_Homo sapiens_hsa043500.13597227

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