CGREF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.79138673
2oligosaccharide catabolic process (GO:0009313)6.69624793
3glutamate secretion (GO:0014047)6.54924115
4synaptic vesicle maturation (GO:0016188)6.50886633
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.94156770
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78813670
7synaptic vesicle exocytosis (GO:0016079)5.71949607
8modified amino acid transport (GO:0072337)5.19135090
9drug transmembrane transport (GO:0006855)5.17556994
10drug transport (GO:0015893)5.06845442
11regulation of synaptic vesicle exocytosis (GO:2000300)5.00165122
12aminoglycoside antibiotic metabolic process (GO:0030647)4.99205842
13urate metabolic process (GO:0046415)4.92872300
14organic cation transport (GO:0015695)4.82400318
15sodium ion export (GO:0071436)4.76945056
16neurotransmitter secretion (GO:0007269)4.71059387
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70624982
18positive regulation of synapse maturation (GO:0090129)4.67208954
19cerebellar granule cell differentiation (GO:0021707)4.65641876
20proline metabolic process (GO:0006560)4.60485941
21cellular potassium ion homeostasis (GO:0030007)4.56335716
22layer formation in cerebral cortex (GO:0021819)4.50675131
23angiotensin maturation (GO:0002003)4.49291071
24renal absorption (GO:0070293)4.30535159
25regulation of neuronal synaptic plasticity (GO:0048168)4.27118624
26drug catabolic process (GO:0042737)4.20751889
27intestinal absorption (GO:0050892)4.18216276
28positive regulation of dendritic spine morphogenesis (GO:0061003)4.16935991
29regulation of synaptic vesicle transport (GO:1902803)4.16169893
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14637811
31excretion (GO:0007588)4.08873740
32protein localization to synapse (GO:0035418)4.04740897
33nonribosomal peptide biosynthetic process (GO:0019184)4.01131417
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96675256
35polyol transport (GO:0015791)3.91867926
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81659706
37ATP synthesis coupled proton transport (GO:0015986)3.81659706
38dopamine transport (GO:0015872)3.80931520
39protein-cofactor linkage (GO:0018065)3.79519895
40locomotory exploration behavior (GO:0035641)3.78889795
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77525853
42peptide biosynthetic process (GO:0043043)3.75962213
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73932699
44NADH metabolic process (GO:0006734)3.72945471
45phosphate ion transport (GO:0006817)3.71854045
46glutathione biosynthetic process (GO:0006750)3.68375837
47protein retention in ER lumen (GO:0006621)3.67610912
48exploration behavior (GO:0035640)3.63536417
49amino acid import (GO:0043090)3.63488459
50cerebellar Purkinje cell layer development (GO:0021680)3.62529303
51deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.62375710
52positive regulation of dendritic spine development (GO:0060999)3.61887962
53negative regulation of dendrite morphogenesis (GO:0050774)3.59747713
54sphingomyelin metabolic process (GO:0006684)3.59372149
55neurotransmitter transport (GO:0006836)3.57328559
56L-amino acid import (GO:0043092)3.48535807
57sulfur compound transport (GO:0072348)3.47302662
58synaptic vesicle endocytosis (GO:0048488)3.45943338
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.45139053
60vocalization behavior (GO:0071625)3.44491652
61regulation of synaptic plasticity (GO:0048167)3.44375362
62regulation of dendritic spine morphogenesis (GO:0061001)3.43597791
63neurotransmitter-gated ion channel clustering (GO:0072578)3.43324437
64glycoside metabolic process (GO:0016137)3.41443104
65exogenous drug catabolic process (GO:0042738)3.40550319
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39779972
67regulation of glutamate receptor signaling pathway (GO:1900449)3.39269066
68folic acid transport (GO:0015884)3.37524989
69neuronal action potential propagation (GO:0019227)3.37366235
70intestinal cholesterol absorption (GO:0030299)3.36509601
71proteasome assembly (GO:0043248)3.36442232
72ionotropic glutamate receptor signaling pathway (GO:0035235)3.36316780
73regulation of synapse maturation (GO:0090128)3.36241826
74respiratory electron transport chain (GO:0022904)3.34530043
75regulation of neurotransmitter levels (GO:0001505)3.32844454
76rRNA modification (GO:0000154)3.31066934
77drinking behavior (GO:0042756)3.30753118
78peptide catabolic process (GO:0043171)3.30497862
79positive regulation of membrane potential (GO:0045838)3.29790347
80protein neddylation (GO:0045116)3.29644437
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.28054898
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.28054898
83phosphate ion homeostasis (GO:0055062)3.27429483
84trivalent inorganic anion homeostasis (GO:0072506)3.27429483
85electron transport chain (GO:0022900)3.24905532
86fructose metabolic process (GO:0006000)3.23496281
87cellular sodium ion homeostasis (GO:0006883)3.23401697
88transferrin transport (GO:0033572)3.22742156
89potassium ion homeostasis (GO:0055075)3.19242384
90cell migration in hindbrain (GO:0021535)3.18102544
91dendritic spine organization (GO:0097061)3.16370024
92mating behavior (GO:0007617)3.15028843
93neuromuscular process controlling balance (GO:0050885)3.14897735
94response to phenylpropanoid (GO:0080184)3.11299812
95regulation of mitochondrial translation (GO:0070129)3.09167188
96synaptic transmission, glutamatergic (GO:0035249)3.08944623
97positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.08519580
98hydrogen ion transmembrane transport (GO:1902600)3.08075737
99regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.07629788
100establishment of mitochondrion localization (GO:0051654)3.07031885
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05488926
102sulfate transmembrane transport (GO:1902358)3.03045060
103ribosome assembly (GO:0042255)3.02788182
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02753444
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02673222
106mitochondrion transport along microtubule (GO:0047497)3.02673222
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.02311199
108termination of RNA polymerase III transcription (GO:0006386)3.02311199
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02138123
110ATP hydrolysis coupled proton transport (GO:0015991)3.02018569
111energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.02018569
112deoxyribonucleotide biosynthetic process (GO:0009263)3.01182462
113nucleobase-containing small molecule interconversion (GO:0015949)2.99625382
114ferric iron transport (GO:0015682)2.99162331
115trivalent inorganic cation transport (GO:0072512)2.99162331
116vitamin D metabolic process (GO:0042359)2.98609445
117vitamin transport (GO:0051180)2.98477747
118dicarboxylic acid transport (GO:0006835)2.98283786
119positive regulation of protein homodimerization activity (GO:0090073)2.96572617
120regulation of synapse structural plasticity (GO:0051823)2.96486535
121sulfate transport (GO:0008272)2.95523564
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.95058848
123actin filament depolymerization (GO:0030042)2.94504471
124regulation of vesicle fusion (GO:0031338)2.91085886
125neuronal ion channel clustering (GO:0045161)2.90769165
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.90714588
127alditol metabolic process (GO:0019400)2.88853489
128removal of superoxide radicals (GO:0019430)2.88305072
129cellular response to superoxide (GO:0071451)2.88305072
130cellular response to oxygen radical (GO:0071450)2.88305072
131DNA deamination (GO:0045006)2.87629041
132phosphate ion transmembrane transport (GO:0035435)2.87435706
133digestion (GO:0007586)2.87408949
134regulation of neurotransmitter secretion (GO:0046928)2.87187176
135neuron-neuron synaptic transmission (GO:0007270)2.86318066
136receptor recycling (GO:0001881)2.85521472
137DNA damage response, detection of DNA damage (GO:0042769)2.85448785
138dopamine biosynthetic process (GO:0042416)2.84819645
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.83902058
140sodium ion transport (GO:0006814)2.83532113
141regulation of ARF protein signal transduction (GO:0032012)2.83412781
142regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83223029
143deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82971702
144positive regulation of neurotransmitter secretion (GO:0001956)2.82944199
1457-methylguanosine mRNA capping (GO:0006370)2.82585687
146neurotransmitter biosynthetic process (GO:0042136)2.80806818
147response to copper ion (GO:0046688)2.80360233
148proton transport (GO:0015992)2.76981695
149hyperosmotic salinity response (GO:0042538)2.75967471
150positive regulation of neurotransmitter transport (GO:0051590)2.75048987
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74711583
152long-term memory (GO:0007616)2.74582362
153hydrogen transport (GO:0006818)2.74268412
1547-methylguanosine RNA capping (GO:0009452)2.73978992
155RNA capping (GO:0036260)2.73978992
156regulation of dendritic spine development (GO:0060998)2.73204037
157regulation of calcium ion-dependent exocytosis (GO:0017158)2.72243948
158regulation of cholesterol biosynthetic process (GO:0045540)2.71719541
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.70910965
160negative regulation of keratinocyte proliferation (GO:0010839)2.70841351
161proline biosynthetic process (GO:0006561)2.70030741
162postsynaptic membrane organization (GO:0001941)2.68668953
163lateral ventricle development (GO:0021670)2.68629552
164glycosphingolipid catabolic process (GO:0046479)2.68087696
165dopamine receptor signaling pathway (GO:0007212)2.67639789
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67422034
167amino sugar catabolic process (GO:0046348)2.67285484
168glycerol metabolic process (GO:0006071)2.65880976
169response to magnesium ion (GO:0032026)2.65121367
170regulation of voltage-gated calcium channel activity (GO:1901385)2.63746731
171regulation of female receptivity (GO:0045924)2.63729302
172cobalamin metabolic process (GO:0009235)2.63652122
173glycolipid catabolic process (GO:0019377)2.63284444
174activation of protein kinase A activity (GO:0034199)2.62379634
175lysine metabolic process (GO:0006553)2.62354157
176lysine catabolic process (GO:0006554)2.62354157
177quaternary ammonium group transport (GO:0015697)2.61196875
178cell communication by electrical coupling (GO:0010644)2.61079201
179bicarbonate transport (GO:0015701)2.60958680
180gamma-aminobutyric acid signaling pathway (GO:0007214)2.60484233
181regulation of postsynaptic membrane potential (GO:0060078)2.60429409
182transepithelial transport (GO:0070633)2.60300297
183neuromuscular process controlling posture (GO:0050884)2.60201737
184acid secretion (GO:0046717)2.59946124
185positive regulation of dendrite development (GO:1900006)2.59670784
186positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59639197
187glutamate receptor signaling pathway (GO:0007215)2.59584455
188regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57933998
189regulation of dendrite morphogenesis (GO:0048814)2.56673000
190dendritic spine morphogenesis (GO:0060997)2.55403822
191behavioral response to cocaine (GO:0048148)2.55232516
192regulation of neurotransmitter transport (GO:0051588)2.52129364
193regulation of synaptic transmission (GO:0050804)2.50969299
194neuron cell-cell adhesion (GO:0007158)2.50908236
195female mating behavior (GO:0060180)2.49065310
196auditory behavior (GO:0031223)2.47836662
197protein kinase C signaling (GO:0070528)2.47228690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01331149
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.92319785
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39944054
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.28961619
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21230642
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.95506697
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.94338530
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73160856
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.68719332
10VDR_22108803_ChIP-Seq_LS180_Human2.67343723
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.66491407
12ZNF263_19887448_ChIP-Seq_K562_Human2.51558540
13LXR_22292898_ChIP-Seq_THP-1_Human2.45591244
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44989097
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.36779399
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.33212143
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.30137227
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.26537892
19DNAJC2_21179169_ChIP-ChIP_NT2_Human2.26392254
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24224781
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23126140
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21556257
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21283524
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21283524
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20147331
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18229940
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15448595
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14052025
29REST_21632747_ChIP-Seq_MESCs_Mouse2.11572575
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10282639
31DROSHA_22980978_ChIP-Seq_HELA_Human2.07305865
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04498608
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.03814207
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03536012
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.02936397
36EZH2_27294783_Chip-Seq_ESCs_Mouse2.01074812
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99406467
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98244234
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97880959
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96799140
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96072508
42KDM2B_26808549_Chip-Seq_K562_Human1.94917859
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.92337095
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.91774110
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.88771163
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.88552736
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86226982
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.81009804
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.79445433
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.75949645
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.74494545
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.74112182
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.73506280
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.73403539
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73396494
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72256920
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.72003267
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.71442325
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71400141
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70784618
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70751097
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67048673
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63108997
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.62338091
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62284596
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62202946
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.61966678
68P68_20966046_ChIP-Seq_HELA_Human1.61488199
69SMC4_20622854_ChIP-Seq_HELA_Human1.59711814
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59364047
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58944183
72CTCF_27219007_Chip-Seq_Bcells_Human1.57563215
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.56905715
74EZH2_22144423_ChIP-Seq_EOC_Human1.55467376
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.53820626
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52751589
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49959571
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.49847874
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49084160
80GBX2_23144817_ChIP-Seq_PC3_Human1.48194080
81CREB1_26743006_Chip-Seq_LNCaP_Human1.45981356
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45699592
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45679622
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43409832
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40130042
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39616386
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38890681
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.37719037
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.36642993
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36195690
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35703055
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34203368
93AR_21909140_ChIP-Seq_LNCAP_Human1.32382334
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29529602
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29426811
96KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28018590
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24705142
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22670145
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22162350
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21649588
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21296879
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20439957
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.19463221
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19158270
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19081174
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19013069
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18592285
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.18015487
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17263490
110MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14835057
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14762393
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14582550
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14002266
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12834724
115* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12464604
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11422684
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09792421
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09233908
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09081753
120TTF2_22483619_ChIP-Seq_HELA_Human1.08594291
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.08521451
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08324530
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07963647
124RBPJ_21746931_ChIP-Seq_IB4_Human1.07739248
125* OCT4_19829295_ChIP-Seq_ESCs_Human1.07604144
126KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07166530
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07166530
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07166530
129SALL1_21062744_ChIP-ChIP_HESCs_Human1.06874529
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06460316
131KDM2B_26808549_Chip-Seq_DND41_Human1.06359674
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05374788
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04483366
134CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03503886
135VDR_23849224_ChIP-Seq_CD4+_Human1.03019331
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02937113
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02762064
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.02392658
139ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02093026
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.01771277
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01193074
142SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00307701
143RING1B_27294783_Chip-Seq_NPCs_Mouse0.99956444
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99927416
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99653937
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99049748
147MYC_19829295_ChIP-Seq_ESCs_Human0.98306166
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98186242
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.98186224
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98117124
151ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97736781
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97546635
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97469947
154KLF4_18555785_Chip-Seq_ESCs_Mouse0.97257042
155NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97159877
156JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97083803
157ETV1_20927104_ChIP-Seq_GIST48_Human0.95088108
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93700993
159NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93064846
160RARA_24833708_ChIP-Seq_LIVER_Mouse0.92884079
161PHF8_20622853_ChIP-Seq_HELA_Human0.92522202
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.90924435
163GATA3_21867929_ChIP-Seq_CD8_Mouse0.90552041
164* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90021284
165CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89737066
166ZFX_18555785_Chip-Seq_ESCs_Mouse0.89610289
167SOX2_18555785_Chip-Seq_ESCs_Mouse0.89251909
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89059938
169CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88776964
170CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88677245
171FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88403434
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.88067478
173SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87170378
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84752708
175ER_23166858_ChIP-Seq_MCF-7_Human0.84301795
176GATA4_25053715_ChIP-Seq_YYC3_Human0.84292962
177CRX_20693478_ChIP-Seq_RETINA_Mouse0.84171442
178RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83723115
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83588715
180ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83532971
181EZH2_27304074_Chip-Seq_ESCs_Mouse0.83528218
182PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.82707310
183BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82470572
184NMYC_18555785_Chip-Seq_ESCs_Mouse0.82317349
185GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82287926
186SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82285006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84359674
2MP0005360_urolithiasis5.81634910
3MP0004043_abnormal_pH_regulation4.30703514
4MP0003880_abnormal_central_pattern4.21024661
5MP0004019_abnormal_vitamin_homeostasis3.95767495
6MP0005377_hearing/vestibular/ear_phenot3.65900197
7MP0003878_abnormal_ear_physiology3.65900197
8MP0003635_abnormal_synaptic_transmissio3.48349815
9MP0005332_abnormal_amino_acid2.97953701
10MP0002064_seizures2.81429697
11MP0002876_abnormal_thyroid_physiology2.78816774
12MP0002063_abnormal_learning/memory/cond2.71690305
13MP0003283_abnormal_digestive_organ2.64807180
14MP0003718_maternal_effect2.51876913
15MP0002272_abnormal_nervous_system2.51146811
16MP0000538_abnormal_urinary_bladder2.43922753
17MP0001765_abnormal_ion_homeostasis2.43063182
18MP0003329_amyloid_beta_deposits2.30506066
19MP0009643_abnormal_urine_homeostasis2.30097743
20MP0009046_muscle_twitch2.20661755
21MP0009780_abnormal_chondrocyte_physiolo2.17849568
22MP0001666_abnormal_nutrient_absorption2.14127102
23MP0003195_calcinosis2.13127486
24MP0003315_abnormal_perineum_morphology2.12071710
25MP0003941_abnormal_skin_development2.08813720
26MP0001486_abnormal_startle_reflex2.07321611
27MP0005084_abnormal_gallbladder_morpholo2.03587605
28MP0001756_abnormal_urination2.01990875
29MP0003123_paternal_imprinting2.01929591
30MP0005636_abnormal_mineral_homeostasis1.97814242
31MP0008569_lethality_at_weaning1.94414583
32MP0001188_hyperpigmentation1.87029779
33MP0002136_abnormal_kidney_physiology1.85076898
34MP0002089_abnormal_postnatal_growth/wei1.82510113
35MP0003693_abnormal_embryo_hatching1.81810047
36MP0003122_maternal_imprinting1.79486555
37MP0010386_abnormal_urinary_bladder1.76367907
38MP0000566_synostosis1.76106874
39MP0010234_abnormal_vibrissa_follicle1.75066945
40MP0001542_abnormal_bone_strength1.72580384
41MP0002735_abnormal_chemical_nociception1.71765547
42MP0001986_abnormal_taste_sensitivity1.65954976
43MP0001664_abnormal_digestion1.58251615
44MP0001501_abnormal_sleep_pattern1.56358919
45MP0002139_abnormal_hepatobiliary_system1.56287951
46MP0005646_abnormal_pituitary_gland1.53876420
47MP0000462_abnormal_digestive_system1.52765484
48MP0005503_abnormal_tendon_morphology1.50979319
49MP0005423_abnormal_somatic_nervous1.49904571
50MP0004264_abnormal_extraembryonic_tissu1.46043875
51MP0001502_abnormal_circadian_rhythm1.45859778
52MP0004811_abnormal_neuron_physiology1.45752677
53MP0002896_abnormal_bone_mineralization1.44750299
54MP0003646_muscle_fatigue1.43703123
55MP0002822_catalepsy1.37402186
56MP0002733_abnormal_thermal_nociception1.36902406
57MP0002067_abnormal_sensory_capabilities1.34171182
58MP0006276_abnormal_autonomic_nervous1.31350086
59MP0002184_abnormal_innervation1.31252489
60MP0002066_abnormal_motor_capabilities/c1.31174540
61MP0003786_premature_aging1.28510300
62MP0002734_abnormal_mechanical_nocicepti1.28017382
63MP0000762_abnormal_tongue_morphology1.27935707
64MP0000955_abnormal_spinal_cord1.26950424
65MP0009379_abnormal_foot_pigmentation1.26422867
66MP0001958_emphysema1.25101671
67MP0003183_abnormal_peptide_metabolism1.24884354
68MP0004858_abnormal_nervous_system1.22750805
69MP0005395_other_phenotype1.22738279
70MP0002882_abnormal_neuron_morphology1.21283807
71MP0003705_abnormal_hypodermis_morpholog1.19563966
72MP0008875_abnormal_xenobiotic_pharmacok1.16605951
73MP0000163_abnormal_cartilage_morphology1.15553605
74MP0003879_abnormal_hair_cell1.14403791
75MP0002160_abnormal_reproductive_system1.12401446
76MP0002277_abnormal_respiratory_mucosa1.12247996
77MP0004270_analgesia1.11619321
78MP0003633_abnormal_nervous_system1.10335957
79MP0001440_abnormal_grooming_behavior1.10331180
80MP0002138_abnormal_hepatobiliary_system1.10063688
81MP0008877_abnormal_DNA_methylation1.09744759
82MP0000920_abnormal_myelination1.09174589
83MP0003634_abnormal_glial_cell1.07152125
84MP0000778_abnormal_nervous_system1.06584254
85MP0001764_abnormal_homeostasis1.06419291
86MP0002249_abnormal_larynx_morphology1.06041029
87MP0001963_abnormal_hearing_physiology1.05371644
88MP0003631_nervous_system_phenotype1.05338375
89MP0002229_neurodegeneration1.05059568
90MP0005386_behavior/neurological_phenoty0.99737620
91MP0004924_abnormal_behavior0.99737620
92MP0002234_abnormal_pharynx_morphology0.98614541
93MP0005381_digestive/alimentary_phenotyp0.95394086
94MP0005409_darkened_coat_color0.94639214
95MP0002115_abnormal_skeleton_extremities0.92984413
96MP0001984_abnormal_olfaction0.92516060
97MP0008995_early_reproductive_senescence0.91913472
98MP0005623_abnormal_meninges_morphology0.91677217
99MP0002152_abnormal_brain_morphology0.91387096
100MP0003186_abnormal_redox_activity0.90475359
101MP0000681_abnormal_thyroid_gland0.89997791
102MP0009745_abnormal_behavioral_response0.89806564
103MP0008058_abnormal_DNA_repair0.89587717
104MP0009250_abnormal_appendicular_skeleto0.89272358
105MP0002163_abnormal_gland_morphology0.89001418
106MP0002098_abnormal_vibrissa_morphology0.88024751
107MP0001663_abnormal_digestive_system0.84720347
108MP0000534_abnormal_ureter_morphology0.84125414
109MP0000604_amyloidosis0.84067929
110MP0004134_abnormal_chest_morphology0.83936883
111MP0003638_abnormal_response/metabolism_0.83905855
112MP0000026_abnormal_inner_ear0.83367032
113MP0000230_abnormal_systemic_arterial0.82347950
114MP0000678_abnormal_parathyroid_gland0.81143940
115MP0002736_abnormal_nociception_after0.79393461
116MP0002933_joint_inflammation0.79004375
117MP0004185_abnormal_adipocyte_glucose0.78503545
118MP0004233_abnormal_muscle_weight0.77522334
119MP0005076_abnormal_cell_differentiation0.77307872
120MP0002113_abnormal_skeleton_development0.76853615
121MP0001177_atelectasis0.74039050
122MP0001905_abnormal_dopamine_level0.73240265
123MP0008874_decreased_physiological_sensi0.72760443
124MP0001968_abnormal_touch/_nociception0.72596372
125MP0002751_abnormal_autonomic_nervous0.72066394
126MP0004133_heterotaxia0.71962478
127MP0001529_abnormal_vocalization0.71266238
128MP0004142_abnormal_muscle_tone0.70929570
129MP0002069_abnormal_eating/drinking_beha0.70486281
130MP0003868_abnormal_feces_composition0.70224984
131MP0003121_genomic_imprinting0.70120995
132MP0008872_abnormal_physiological_respon0.69810034
133MP0003632_abnormal_nervous_system0.69018967
134MP0002557_abnormal_social/conspecific_i0.68908610
135MP0004885_abnormal_endolymph0.68805050
136MP0008438_abnormal_cutaneous_collagen0.68301448
137MP0005645_abnormal_hypothalamus_physiol0.67773227
138MP0003795_abnormal_bone_structure0.67493906
139MP0003866_abnormal_defecation0.67100771
140MP0003690_abnormal_glial_cell0.64738294
141MP0005058_abnormal_lysosome_morphology0.64723148
142MP0006035_abnormal_mitochondrial_morpho0.64378374
143MP0004742_abnormal_vestibular_system0.63579327
144MP0006292_abnormal_olfactory_placode0.63191976
145MP0001970_abnormal_pain_threshold0.63011970
146MP0003111_abnormal_nucleus_morphology0.62611773
147MP0002572_abnormal_emotion/affect_behav0.62401353
148MP0005666_abnormal_adipose_tissue0.62379556
149MP0005389_reproductive_system_phenotype0.61875042
150MP0008260_abnormal_autophagy0.61087496
151MP0008932_abnormal_embryonic_tissue0.61027642
152MP0002210_abnormal_sex_determination0.60973915
153MP0002638_abnormal_pupillary_reflex0.60947881
154MP0000747_muscle_weakness0.60589957
155MP0000003_abnormal_adipose_tissue0.60328942
156MP0001346_abnormal_lacrimal_gland0.59213854
157MP0002135_abnormal_kidney_morphology0.58830177
158MP0005451_abnormal_body_composition0.58725509
159MP0008789_abnormal_olfactory_epithelium0.58616787
160MP0002909_abnormal_adrenal_gland0.58584660
161MP0003075_altered_response_to0.58374653
162MP0008004_abnormal_stomach_pH0.58307303
163MP0005408_hypopigmentation0.57582845
164MP0003861_abnormal_nervous_system0.56659793
165MP0003956_abnormal_body_size0.56459247
166MP0002161_abnormal_fertility/fecundity0.56013179

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.44381663
2Focal motor seizures (HP:0011153)5.87535384
3Delayed epiphyseal ossification (HP:0002663)5.08943829
4Proximal tubulopathy (HP:0000114)5.03960049
5Focal seizures (HP:0007359)4.49796165
6Hyperactive renin-angiotensin system (HP:0000841)4.47741026
7Hypomagnesemia (HP:0002917)4.45994711
8Increased circulating renin level (HP:0000848)4.45132082
9Metabolic alkalosis (HP:0200114)4.35955784
10Irregular epiphyses (HP:0010582)4.29098775
11Abnormality of magnesium homeostasis (HP:0004921)4.26064749
12Action tremor (HP:0002345)4.15486782
13Metaphyseal cupping (HP:0003021)4.12014576
14Epiphyseal dysplasia (HP:0002656)4.09761810
15Abnormal tarsal ossification (HP:0008369)4.02621843
16Febrile seizures (HP:0002373)3.92799896
17Epileptic encephalopathy (HP:0200134)3.90569832
18Polyuria (HP:0000103)3.87962488
19Abnormal urine output (HP:0012590)3.85351011
20Abnormality of chloride homeostasis (HP:0011422)3.80559480
21Gout (HP:0001997)3.77336691
22Genu varum (HP:0002970)3.71833065
23Ankle clonus (HP:0011448)3.70887573
24Abnormality of renal excretion (HP:0011036)3.69913867
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65948175
26Supranuclear gaze palsy (HP:0000605)3.63825974
27Cupped ribs (HP:0000887)3.63462680
28Hypokalemic alkalosis (HP:0001949)3.63220718
29Metaphyseal irregularity (HP:0003025)3.58101282
30Hyperuricemia (HP:0002149)3.38373867
31Increased purine levels (HP:0004368)3.38373867
32Hypercalciuria (HP:0002150)3.32112565
33Hyperaldosteronism (HP:0000859)3.30577595
34Carpal bone hypoplasia (HP:0001498)3.28659106
35Hyperphosphaturia (HP:0003109)3.26893765
36Truncal ataxia (HP:0002078)3.14543922
37Torticollis (HP:0000473)3.14063436
38Atonic seizures (HP:0010819)3.13812136
39Widely patent fontanelles and sutures (HP:0004492)3.10935919
40Metaphyseal dysplasia (HP:0100255)3.10199703
41Dysmetria (HP:0001310)3.08338265
42Neurofibrillary tangles (HP:0002185)3.08250863
43Visual hallucinations (HP:0002367)3.07140066
44Osteomalacia (HP:0002749)3.04680635
45Spinal cord compression (HP:0002176)3.04399085
46Abnormal urine phosphate concentration (HP:0012599)2.99237676
47Deep venous thrombosis (HP:0002625)2.97343666
48Abnormality of urine glucose concentration (HP:0011016)2.96336176
49Glycosuria (HP:0003076)2.96336176
50Cerebral inclusion bodies (HP:0100314)2.92270475
51Flat capital femoral epiphysis (HP:0003370)2.91484331
52Hydroxyprolinuria (HP:0003080)2.88943351
53Abnormality of proline metabolism (HP:0010907)2.88943351
54Tetany (HP:0001281)2.87842957
55Abnormality of renin-angiotensin system (HP:0000847)2.86676689
56Abnormal drinking behavior (HP:0030082)2.86203300
57Polydipsia (HP:0001959)2.86203300
58Progressive external ophthalmoplegia (HP:0000590)2.84587144
59Limb dystonia (HP:0002451)2.84445645
60Enlarged epiphyses (HP:0010580)2.83295304
61Cholecystitis (HP:0001082)2.79244828
62Abnormal gallbladder physiology (HP:0012438)2.79244828
63Hyperglycinuria (HP:0003108)2.76318801
64Neonatal short-limb short stature (HP:0008921)2.76056894
65Intention tremor (HP:0002080)2.75851765
66Abnormality of carpal bone ossification (HP:0006257)2.74919185
67Distal upper limb amyotrophy (HP:0007149)2.74711547
68Upper limb amyotrophy (HP:0009129)2.74711547
69Vitreoretinal degeneration (HP:0000655)2.74643248
70Annular pancreas (HP:0001734)2.74104230
71Small epiphyses (HP:0010585)2.73841291
72Generalized tonic-clonic seizures (HP:0002069)2.71354290
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68541582
74Focal dystonia (HP:0004373)2.66742610
75Akinesia (HP:0002304)2.65762960
76Hand muscle atrophy (HP:0009130)2.64930182
77Renal salt wasting (HP:0000127)2.64487222
78Cerebral hypomyelination (HP:0006808)2.62319483
79Spastic gait (HP:0002064)2.61464656
80Renal tubular acidosis (HP:0001947)2.57650396
81Impaired vibration sensation in the lower limbs (HP:0002166)2.52629412
82Abnormal foot bone ossification (HP:0010675)2.52610641
83Abnormality of purine metabolism (HP:0004352)2.52312941
84Craniofacial dystonia (HP:0012179)2.52158757
85Obstructive sleep apnea (HP:0002870)2.51461777
86Dysmetric saccades (HP:0000641)2.50426270
87Mild short stature (HP:0003502)2.49104599
88Short femoral neck (HP:0100864)2.48808625
89Flat acetabular roof (HP:0003180)2.48641424
90Scanning speech (HP:0002168)2.45703265
91Insomnia (HP:0100785)2.41615567
92Achilles tendon contracture (HP:0001771)2.40877741
93Depression (HP:0000716)2.40190589
94Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.40151733
95Abnormality of femoral epiphyses (HP:0006499)2.40151733
96Status epilepticus (HP:0002133)2.37822588
97Abnormality of the Achilles tendon (HP:0005109)2.34742908
98Alkalosis (HP:0001948)2.34439040
99Epileptiform EEG discharges (HP:0011182)2.32760332
100Abnormality of the epiphysis of the femoral head (HP:0010574)2.32414143
101Neuronal loss in central nervous system (HP:0002529)2.29648308
102Urinary bladder sphincter dysfunction (HP:0002839)2.29201905
103Hypophosphatemia (HP:0002148)2.28964713
104Absence seizures (HP:0002121)2.28863219
105Acute necrotizing encephalopathy (HP:0006965)2.28563921
106Abnormal eating behavior (HP:0100738)2.27579802
107Abnormality of the vertebral endplates (HP:0005106)2.26894439
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.26164153
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25221583
110Acute encephalopathy (HP:0006846)2.24981368
111Urinary urgency (HP:0000012)2.24771466
112Athetosis (HP:0002305)2.21384670
113Abnormality of renal resorption (HP:0011038)2.21018831
114Fetal akinesia sequence (HP:0001989)2.20573467
115Stillbirth (HP:0003826)2.20296258
116Amblyopia (HP:0000646)2.20120314
117Hypokalemia (HP:0002900)2.19528853
118Aplasia of the musculature (HP:0100854)2.16501627
119Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16037801
120Apathy (HP:0000741)2.15478986
121Duplicated collecting system (HP:0000081)2.14585416
122Ileus (HP:0002595)2.14344231
123Renal tubular dysfunction (HP:0000124)2.14249287
124Delusions (HP:0000746)2.13177231
125Irregular vertebral endplates (HP:0003301)2.12932199
126Abnormality of the femoral head (HP:0003368)2.12825981
127Rickets (HP:0002748)2.11684788
128Abnormality of binocular vision (HP:0011514)2.11588234
129Diplopia (HP:0000651)2.11588234
130Premature skin wrinkling (HP:0100678)2.11329156
131EEG with generalized epileptiform discharges (HP:0011198)2.10878818
132Coxa vara (HP:0002812)2.10414774
133Poor eye contact (HP:0000817)2.07884103
134Flattened epiphyses (HP:0003071)2.05843221
135Abnormal trabecular bone morphology (HP:0100671)2.04721626
136Dialeptic seizures (HP:0011146)2.03991254
137Wide cranial sutures (HP:0010537)2.03658152
138Diminished motivation (HP:0000745)2.03193132
139Dysdiadochokinesis (HP:0002075)2.02926534
140Rough bone trabeculation (HP:0100670)2.01664509
141Abnormal mitochondria in muscle tissue (HP:0008316)2.01594954
142Glucose intolerance (HP:0000833)2.01348338
143Abnormality of the proximal phalanges of the hand (HP:0009834)2.00891749
144Malnutrition (HP:0004395)1.98775216
145Limb ataxia (HP:0002070)1.98567446
146Hyperthyroidism (HP:0000836)1.98310158
147Hypsarrhythmia (HP:0002521)1.97870802
148Abnormal glucose tolerance (HP:0001952)1.97469359
149Megaloblastic anemia (HP:0001889)1.96991757
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96855087
151J-shaped sella turcica (HP:0002680)1.96839308
152Mitochondrial inheritance (HP:0001427)1.96716483
153Mutism (HP:0002300)1.96671375
154Abnormality of nucleobase metabolism (HP:0010932)1.96269633
155Neonatal onset (HP:0003623)1.95902912
156Nephrocalcinosis (HP:0000121)1.95314810
157Bradykinesia (HP:0002067)1.94246557
158Hyperacusis (HP:0010780)1.93404351
159Barrel-shaped chest (HP:0001552)1.91999450
160Insidious onset (HP:0003587)1.91425282
161Termporal pattern (HP:0011008)1.91425282
162Abnormality of calcium-phosphate metabolism (HP:0100530)1.91302913
163Diminished movement (HP:0002374)1.90874408
164Aplasia/hypoplasia of the uterus (HP:0008684)1.90845348
165Platyspondyly (HP:0000926)1.90182087
166Hypercortisolism (HP:0001578)1.89138791
167Impaired smooth pursuit (HP:0007772)1.87227607
168Abnormality of the lower motor neuron (HP:0002366)1.87148851
169Abnormality of the renal collecting system (HP:0004742)1.86483718
170Tetraplegia (HP:0002445)1.86274400
171Abnormal hand bone ossification (HP:0010660)1.86143051
172Hip contracture (HP:0003273)1.85606387
173Postural instability (HP:0002172)1.85568830
174Breast hypoplasia (HP:0003187)1.84692530
175Progressive cerebellar ataxia (HP:0002073)1.84579248
176Hypokinesia (HP:0002375)1.83610320
177Rigidity (HP:0002063)1.82877823
178Anxiety (HP:0000739)1.80891462
179Bronchomalacia (HP:0002780)1.78562087
180Hyperparathyroidism (HP:0000843)1.76770025
181Hammertoe (HP:0001765)1.75039958
182Growth hormone excess (HP:0000845)1.71255185
183Shallow orbits (HP:0000586)1.70694555
184Clonus (HP:0002169)1.70435508
185Abnormality of the corticospinal tract (HP:0002492)1.69971573
186Aplasia involving bones of the extremities (HP:0009825)1.69646972
187Aplasia involving bones of the upper limbs (HP:0009823)1.69646972
188Aplasia of the phalanges of the hand (HP:0009802)1.69646972
189Abnormal social behavior (HP:0012433)1.69350358
190Impaired social interactions (HP:0000735)1.69350358
191Microglossia (HP:0000171)1.66577751
192Fibular aplasia (HP:0002990)1.64673186
193Distal sensory impairment (HP:0002936)1.64105397
194Testicular atrophy (HP:0000029)1.62027280
195Abnormality of glycolysis (HP:0004366)1.60580585
196Lower limb muscle weakness (HP:0007340)1.58136107
197Spinal canal stenosis (HP:0003416)1.57903289
198Spastic tetraparesis (HP:0001285)1.57406734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.65858474
2MARK14.05330615
3WNK33.78245339
4PRKD33.51593133
5STK38L3.40688346
6ZAK3.35232188
7TRIB33.23362149
8STK163.17215799
9WNK43.13105178
10PLK43.04434344
11EPHA22.90768120
12PAK62.75848619
13OXSR12.67100795
14NME12.67094925
15MAP3K92.63830720
16IRAK22.36862877
17DAPK22.23337549
18BUB12.18320770
19NTRK12.07576531
20EEF2K2.05395919
21MST42.04878706
22CAMKK12.02254605
23IRAK41.96401227
24SIK11.80745741
25IRAK11.72633966
26PHKG11.69142004
27PHKG21.69142004
28PRKCI1.67269542
29PNCK1.63862960
30SCYL21.58105811
31PINK11.54092162
32LATS21.53047798
33DAPK11.50880923
34ICK1.50585431
35NTRK21.47193289
36EIF2AK31.38959307
37KSR21.37976847
38AKT31.32438624
39MAP3K131.30607955
40UHMK11.30122957
41FRK1.23443233
42MARK21.19729116
43PLK21.19373068
44DDR21.17228788
45PLK31.15949583
46BRSK11.15862780
47TTK1.15526332
48SRPK11.15162079
49RIPK11.14536951
50MAP3K121.13667912
51MAP3K31.13070423
52PRPF4B1.08915463
53SIK21.08830200
54CDK51.07376453
55SMG11.06377542
56PKN21.05846887
57EIF2AK11.01816721
58CDK151.00220844
59MAP2K70.98622115
60CDC42BPA0.97345545
61PDPK10.96372465
62CDK180.94951156
63CAMK10.92764230
64CAMK1D0.92162451
65CDK11A0.90891755
66STK240.88750928
67WEE10.84452763
68NEK60.84425648
69RAF10.83888585
70TNK20.82034774
71NEK10.81068990
72PDK20.81028025
73NME20.81019120
74CDK140.80052616
75STK390.79139944
76PTK20.78865223
77GRK60.78080010
78CASK0.78056979
79MST1R0.77017055
80PIM20.75521605
81NTRK30.75083488
82EPHA40.74624042
83TSSK60.74212236
84TYRO30.73069432
85CDK120.72010310
86PRKG20.71352366
87EIF2AK20.70865121
88CAMK1G0.68811290
89TESK20.68436060
90VRK10.67903380
91CDK30.64723414
92DAPK30.64570778
93PDK10.64194926
94MAP3K40.63849948
95TAOK20.63047017
96PRKD20.62550505
97ALK0.59262075
98PKN10.58858757
99AURKA0.58148370
100MINK10.57863557
101CAMK2D0.57171101
102TNIK0.56922622
103ABL20.56840104
104BRAF0.56123482
105CAMK2B0.55721402
106PLK10.55671345
107ILK0.54948727
108SGK2230.54844800
109SGK4940.54844800
110MAPKAPK30.53833410
111DYRK20.53770178
112PDGFRA0.53495327
113ERBB30.52921129
114MAP2K20.52345345
115STK380.51098197
116CAMK2G0.50907964
117PRKCE0.50889335
118BMPR20.50777000
119PRKCG0.50302157
120ACVR1B0.50288547
121RET0.48762397
122TLK10.47707129
123MAPK100.47480249
124BMPR1B0.46790646
125LIMK10.46768855
126TESK10.46696559
127ARAF0.44843610
128MTOR0.44720507
129FGFR40.43731667
130MUSK0.43082470
131DYRK1A0.42890877
132MAPK120.42658004
133CAMKK20.42451098
134MAPKAPK50.42386228
135CHEK20.41845327
136MAP3K10.40879547
137CSNK1E0.40324366
138RPS6KA20.40030035
139MET0.39798193
140FER0.39556180
141PAK40.39412393
142GRK50.38993728
143BRD40.37159425
144CDK80.37147432
145AKT20.36823291
146MAP3K110.36613407
147MAPK130.35803594
148LMTK20.35166141
149ROCK10.35099573
150RPS6KA30.35064734
151MYLK0.34942674
152PDK40.33517043
153PDK30.33517043
154TAOK10.30910679
155PBK0.29450888
156CAMK2A0.28899709
157INSRR0.28744985
158GRK10.28088551
159GRK70.26276743
160PRKCZ0.25313787
161SGK20.25290668
162CSNK2A10.24395481
163MAP2K60.23961860
164PRKCD0.23386628
165PRKCA0.22948397

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.42517369
2Vitamin digestion and absorption_Homo sapiens_hsa049773.33292484
3Collecting duct acid secretion_Homo sapiens_hsa049663.06696078
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.04348916
5Mineral absorption_Homo sapiens_hsa049782.69871792
6Vitamin B6 metabolism_Homo sapiens_hsa007502.67480968
7Parkinsons disease_Homo sapiens_hsa050122.66660955
8Protein digestion and absorption_Homo sapiens_hsa049742.63031131
9Renin-angiotensin system_Homo sapiens_hsa046142.61809200
10Long-term potentiation_Homo sapiens_hsa047202.39689822
11Proteasome_Homo sapiens_hsa030502.36538527
12RNA polymerase_Homo sapiens_hsa030202.33103229
13Glutathione metabolism_Homo sapiens_hsa004802.17960305
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05476208
15Huntingtons disease_Homo sapiens_hsa050162.01790950
16GABAergic synapse_Homo sapiens_hsa047271.98343615
17Glutamatergic synapse_Homo sapiens_hsa047241.90548178
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90131910
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89276616
20Sulfur metabolism_Homo sapiens_hsa009201.89030919
21Folate biosynthesis_Homo sapiens_hsa007901.87013326
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86034886
23Sphingolipid metabolism_Homo sapiens_hsa006001.83389576
24Circadian entrainment_Homo sapiens_hsa047131.82563585
25Fat digestion and absorption_Homo sapiens_hsa049751.81170404
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75893674
27Morphine addiction_Homo sapiens_hsa050321.73291376
28Dopaminergic synapse_Homo sapiens_hsa047281.69499054
29Alzheimers disease_Homo sapiens_hsa050101.69027184
30Insulin secretion_Homo sapiens_hsa049111.68886087
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68719582
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65446459
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63053117
34Vibrio cholerae infection_Homo sapiens_hsa051101.59537597
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58767857
36Butanoate metabolism_Homo sapiens_hsa006501.56104650
37Arginine and proline metabolism_Homo sapiens_hsa003301.53422039
38Galactose metabolism_Homo sapiens_hsa000521.52793032
39Pyrimidine metabolism_Homo sapiens_hsa002401.52251402
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49241213
41Cocaine addiction_Homo sapiens_hsa050301.48751720
42Starch and sucrose metabolism_Homo sapiens_hsa005001.47678403
43Fructose and mannose metabolism_Homo sapiens_hsa000511.46300276
44Arginine biosynthesis_Homo sapiens_hsa002201.42062651
45Synaptic vesicle cycle_Homo sapiens_hsa047211.41982453
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39841492
47Cholinergic synapse_Homo sapiens_hsa047251.39319709
48Fatty acid biosynthesis_Homo sapiens_hsa000611.35456025
49Arachidonic acid metabolism_Homo sapiens_hsa005901.35086673
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.32295851
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31987246
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30406383
53Glioma_Homo sapiens_hsa052141.27909809
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25832455
55Other glycan degradation_Homo sapiens_hsa005111.24412741
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24294116
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23133523
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19564373
59Salivary secretion_Homo sapiens_hsa049701.18779987
60Ribosome_Homo sapiens_hsa030101.12498244
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11784074
62Biosynthesis of amino acids_Homo sapiens_hsa012301.11049417
63Purine metabolism_Homo sapiens_hsa002301.10667280
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09558108
65Calcium signaling pathway_Homo sapiens_hsa040201.09127535
66Oxytocin signaling pathway_Homo sapiens_hsa049211.05310513
67Fanconi anemia pathway_Homo sapiens_hsa034601.04897559
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04584585
69Oocyte meiosis_Homo sapiens_hsa041141.03813712
70beta-Alanine metabolism_Homo sapiens_hsa004101.03368377
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01397684
72Estrogen signaling pathway_Homo sapiens_hsa049151.00476023
73Gap junction_Homo sapiens_hsa045400.99814803
74ErbB signaling pathway_Homo sapiens_hsa040120.99458556
75Peroxisome_Homo sapiens_hsa041460.99127475
76Cardiac muscle contraction_Homo sapiens_hsa042600.95824468
77Pyruvate metabolism_Homo sapiens_hsa006200.95053389
78Renin secretion_Homo sapiens_hsa049240.93114368
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93018789
80Metabolic pathways_Homo sapiens_hsa011000.93003088
81Glucagon signaling pathway_Homo sapiens_hsa049220.92422743
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.91360689
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91061759
84VEGF signaling pathway_Homo sapiens_hsa043700.90355921
85Long-term depression_Homo sapiens_hsa047300.89851138
86Bile secretion_Homo sapiens_hsa049760.89020892
87Sulfur relay system_Homo sapiens_hsa041220.88382487
88GnRH signaling pathway_Homo sapiens_hsa049120.86143066
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84570940
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83408116
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83187355
92AMPK signaling pathway_Homo sapiens_hsa041520.81526386
93mTOR signaling pathway_Homo sapiens_hsa041500.79374237
94cAMP signaling pathway_Homo sapiens_hsa040240.78789026
95Glycerolipid metabolism_Homo sapiens_hsa005610.76441563
96Tryptophan metabolism_Homo sapiens_hsa003800.75889261
97Prion diseases_Homo sapiens_hsa050200.74964779
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74843461
99Melanogenesis_Homo sapiens_hsa049160.74711787
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74677895
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74173956
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73530885
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73412767
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71853823
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71661473
106Axon guidance_Homo sapiens_hsa043600.69315031
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.68974288
108Nicotine addiction_Homo sapiens_hsa050330.67528407
109Basal transcription factors_Homo sapiens_hsa030220.67194481
110Protein export_Homo sapiens_hsa030600.66530320
111Insulin signaling pathway_Homo sapiens_hsa049100.66443574
112Fatty acid metabolism_Homo sapiens_hsa012120.63269630
113Pancreatic secretion_Homo sapiens_hsa049720.62776966
114N-Glycan biosynthesis_Homo sapiens_hsa005100.61066071
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61010782
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.59879067
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58607711
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.57612022
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57542232
120Histidine metabolism_Homo sapiens_hsa003400.57392068
121Carbon metabolism_Homo sapiens_hsa012000.57364958
122Phenylalanine metabolism_Homo sapiens_hsa003600.56209697
123Phototransduction_Homo sapiens_hsa047440.54381223
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51596294
125Regulation of autophagy_Homo sapiens_hsa041400.50809866
126Choline metabolism in cancer_Homo sapiens_hsa052310.49701779
127Non-small cell lung cancer_Homo sapiens_hsa052230.48402606
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.48366490
129One carbon pool by folate_Homo sapiens_hsa006700.47822873
130Inositol phosphate metabolism_Homo sapiens_hsa005620.47763659
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47425433
132Fatty acid elongation_Homo sapiens_hsa000620.46561865
133Propanoate metabolism_Homo sapiens_hsa006400.46404383
134Ovarian steroidogenesis_Homo sapiens_hsa049130.46074523
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46005220
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45585857
137Rheumatoid arthritis_Homo sapiens_hsa053230.45235327
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45121403
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.44509465
140Thyroid hormone synthesis_Homo sapiens_hsa049180.44180721
141Endometrial cancer_Homo sapiens_hsa052130.43326409
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41976596
143Graft-versus-host disease_Homo sapiens_hsa053320.41601280
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41351873
145Homologous recombination_Homo sapiens_hsa034400.40759145
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40449774
147Pentose phosphate pathway_Homo sapiens_hsa000300.40307662
148ECM-receptor interaction_Homo sapiens_hsa045120.39320729
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39127518
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.37999035
151Taste transduction_Homo sapiens_hsa047420.37136091
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36020481
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34738130
154Steroid biosynthesis_Homo sapiens_hsa001000.34096708
155Serotonergic synapse_Homo sapiens_hsa047260.33704629
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33321847
157Alcoholism_Homo sapiens_hsa050340.33315689
158p53 signaling pathway_Homo sapiens_hsa041150.31532837
159Endocytosis_Homo sapiens_hsa041440.30508540
160Wnt signaling pathway_Homo sapiens_hsa043100.30367196
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29179888
162Olfactory transduction_Homo sapiens_hsa047400.28288571
163DNA replication_Homo sapiens_hsa030300.28127694
164Gastric acid secretion_Homo sapiens_hsa049710.25998515
165Amphetamine addiction_Homo sapiens_hsa050310.25936794
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.24518394
167Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24407567
168Mismatch repair_Homo sapiens_hsa034300.24217442

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