CGRRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.43834483
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53598853
3L-phenylalanine catabolic process (GO:0006559)5.53598853
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.19810784
5L-phenylalanine metabolic process (GO:0006558)5.19810784
6aromatic amino acid family catabolic process (GO:0009074)4.80628237
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.62180254
8bile acid biosynthetic process (GO:0006699)4.53182817
9platelet dense granule organization (GO:0060155)4.50012721
10response to pheromone (GO:0019236)4.26157231
11respiratory chain complex IV assembly (GO:0008535)4.24856394
12glyoxylate metabolic process (GO:0046487)4.23928548
13peptidyl-glutamic acid carboxylation (GO:0017187)4.22119795
14protein carboxylation (GO:0018214)4.22119795
15protein localization to cilium (GO:0061512)4.18085166
16tryptophan catabolic process (GO:0006569)4.16223207
17indole-containing compound catabolic process (GO:0042436)4.16223207
18indolalkylamine catabolic process (GO:0046218)4.16223207
19water-soluble vitamin biosynthetic process (GO:0042364)4.12891956
20protein complex biogenesis (GO:0070271)4.11713394
21tryptophan metabolic process (GO:0006568)4.03308517
22low-density lipoprotein particle remodeling (GO:0034374)4.00209704
23lysine metabolic process (GO:0006553)3.99043258
24lysine catabolic process (GO:0006554)3.99043258
25regulation of cholesterol esterification (GO:0010872)3.95423230
26cysteine metabolic process (GO:0006534)3.95197852
27alpha-linolenic acid metabolic process (GO:0036109)3.90409611
28negative regulation of fibrinolysis (GO:0051918)3.89476169
29high-density lipoprotein particle remodeling (GO:0034375)3.85233037
30kynurenine metabolic process (GO:0070189)3.85063163
31proteasome assembly (GO:0043248)3.85000420
32coenzyme catabolic process (GO:0009109)3.83876972
33cofactor catabolic process (GO:0051187)3.82653558
34mitochondrial respiratory chain complex assembly (GO:0033108)3.81893366
35urea metabolic process (GO:0019627)3.81794806
36urea cycle (GO:0000050)3.81794806
37homocysteine metabolic process (GO:0050667)3.81518608
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79348824
39aldehyde catabolic process (GO:0046185)3.78337287
40sulfur amino acid catabolic process (GO:0000098)3.77900156
41cytochrome complex assembly (GO:0017004)3.73525747
42amino-acid betaine metabolic process (GO:0006577)3.73494432
43regulation of triglyceride catabolic process (GO:0010896)3.73417645
44plasma lipoprotein particle remodeling (GO:0034369)3.70520435
45protein-lipid complex remodeling (GO:0034368)3.70520435
46macromolecular complex remodeling (GO:0034367)3.70520435
47complement activation, alternative pathway (GO:0006957)3.68904626
48regulation of protein activation cascade (GO:2000257)3.66470494
49bile acid metabolic process (GO:0008206)3.66222186
50reverse cholesterol transport (GO:0043691)3.64102907
51regulation of fibrinolysis (GO:0051917)3.61962254
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58349915
53DNA double-strand break processing (GO:0000729)3.56908325
54nitrogen cycle metabolic process (GO:0071941)3.55285143
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53998221
56regulation of hexokinase activity (GO:1903299)3.53947847
57regulation of glucokinase activity (GO:0033131)3.53947847
58lactate metabolic process (GO:0006089)3.51975606
59phospholipid efflux (GO:0033700)3.51620502
60positive regulation of mitochondrial fission (GO:0090141)3.51606192
61regulation of complement activation (GO:0030449)3.48324413
62acylglycerol homeostasis (GO:0055090)3.43217014
63triglyceride homeostasis (GO:0070328)3.43217014
64tyrosine metabolic process (GO:0006570)3.43198472
65cullin deneddylation (GO:0010388)3.42057669
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.41929650
67NADH dehydrogenase complex assembly (GO:0010257)3.41929650
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41929650
69alpha-amino acid catabolic process (GO:1901606)3.41546994
70negative regulation of heart rate (GO:0010459)3.39614144
71aromatic amino acid family metabolic process (GO:0009072)3.38511869
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34280901
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34280901
74drug transmembrane transport (GO:0006855)3.31501786
75carnitine metabolic process (GO:0009437)3.22500974
76arginine metabolic process (GO:0006525)3.19049678
77fatty acid beta-oxidation (GO:0006635)3.19005294
78cellular amino acid catabolic process (GO:0009063)3.18428623
79cellular glucuronidation (GO:0052695)3.17746328
80regulation of cilium movement (GO:0003352)3.17532728
81oxaloacetate metabolic process (GO:0006107)3.16962589
82plasma lipoprotein particle clearance (GO:0034381)3.16959579
83protein deneddylation (GO:0000338)3.13631431
84valine metabolic process (GO:0006573)3.12135953
85aspartate family amino acid catabolic process (GO:0009068)3.11392124
86regulation of plasminogen activation (GO:0010755)3.11348841
87intraciliary transport (GO:0042073)3.10961076
88cellular modified amino acid catabolic process (GO:0042219)3.08413254
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.04694147
90lipid oxidation (GO:0034440)3.04629748
91drug catabolic process (GO:0042737)3.04586556
92short-chain fatty acid metabolic process (GO:0046459)3.04073475
93succinate metabolic process (GO:0006105)3.03831356
94complement activation, classical pathway (GO:0006958)3.02999187
95fatty acid oxidation (GO:0019395)3.02792576
96serine family amino acid catabolic process (GO:0009071)3.02111653
97ATP synthesis coupled proton transport (GO:0015986)3.02081947
98energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02081947
99indolalkylamine metabolic process (GO:0006586)3.01519822
100cellular ketone body metabolic process (GO:0046950)3.01502104
1012-oxoglutarate metabolic process (GO:0006103)3.01321339
102fatty acid catabolic process (GO:0009062)3.00191518
103uronic acid metabolic process (GO:0006063)3.00130272
104glucuronate metabolic process (GO:0019585)3.00130272
105glutamate metabolic process (GO:0006536)2.99940905
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.99931916
107termination of RNA polymerase III transcription (GO:0006386)2.99931916
108monocarboxylic acid catabolic process (GO:0072329)2.99637246
109positive regulation of triglyceride lipase activity (GO:0061365)2.99173757
110positive regulation of lipoprotein lipase activity (GO:0051006)2.99173757
111cholesterol efflux (GO:0033344)2.98956559
112organic acid catabolic process (GO:0016054)2.98584227
113carboxylic acid catabolic process (GO:0046395)2.98584227
114plasma lipoprotein particle organization (GO:0071827)2.97540581
115plasma lipoprotein particle assembly (GO:0034377)2.97436803
116complement activation (GO:0006956)2.93779118
117benzene-containing compound metabolic process (GO:0042537)2.93343248
118cellular biogenic amine catabolic process (GO:0042402)2.91520454
119amine catabolic process (GO:0009310)2.91520454
120bile acid and bile salt transport (GO:0015721)2.89439251
121opsonization (GO:0008228)2.88885392
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.87920856
123L-ascorbic acid metabolic process (GO:0019852)2.87350662
124fructose metabolic process (GO:0006000)2.86660774
125sequestering of actin monomers (GO:0042989)2.85537386
126lipoprotein metabolic process (GO:0042157)2.84881138
127branched-chain amino acid catabolic process (GO:0009083)2.84236022
128xenobiotic catabolic process (GO:0042178)2.82316186
129electron transport chain (GO:0022900)2.81637636
130regulation of cholesterol homeostasis (GO:2000188)2.81559559
131signal peptide processing (GO:0006465)2.81338106
132protein activation cascade (GO:0072376)2.81248837
133peroxisome fission (GO:0016559)2.80756477
134DNA damage response, detection of DNA damage (GO:0042769)2.80615290
135fibrinolysis (GO:0042730)2.80362897
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80047560
137cilium morphogenesis (GO:0060271)2.79755923
138negative regulation of lipase activity (GO:0060192)2.79553783
139respiratory electron transport chain (GO:0022904)2.79246894
140dopamine transport (GO:0015872)2.79192403
141cilium organization (GO:0044782)2.78699000
142negative regulation of membrane potential (GO:0045837)2.75385044
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74433030
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72079071
145cilium assembly (GO:0042384)2.71924760
146epithelial cilium movement (GO:0003351)2.66825855
147mannosylation (GO:0097502)2.66660149
148neural tube formation (GO:0001841)2.62115333
149establishment of melanosome localization (GO:0032401)2.60771413
150DNA deamination (GO:0045006)2.59898265
151inositol phosphate catabolic process (GO:0071545)2.59389192
152CENP-A containing nucleosome assembly (GO:0034080)2.58873874
153anterograde synaptic vesicle transport (GO:0048490)2.56811369
154ketone body metabolic process (GO:1902224)2.56762928
155melanosome transport (GO:0032402)2.56494157
156chromatin remodeling at centromere (GO:0031055)2.54901881
157ubiquinone metabolic process (GO:0006743)2.52673464
158axoneme assembly (GO:0035082)2.52311671
159replication fork processing (GO:0031297)2.50389614
160polyol catabolic process (GO:0046174)2.50165593
161protein-cofactor linkage (GO:0018065)2.48865819
162establishment of pigment granule localization (GO:0051905)2.48718084
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48304197
164presynaptic membrane assembly (GO:0097105)2.47544349
165negative regulation of cation channel activity (GO:2001258)2.47327115
166negative regulation of appetite (GO:0032099)2.46280880
167negative regulation of response to food (GO:0032096)2.46280880
168positive regulation of glycolytic process (GO:0045821)2.46076389
169regulation of mitochondrial fission (GO:0090140)2.45815686
170resolution of meiotic recombination intermediates (GO:0000712)2.45290667
171adenosine metabolic process (GO:0046085)2.44507863
172pigment granule transport (GO:0051904)2.44087370
173ubiquinone biosynthetic process (GO:0006744)2.43352835
174somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43098106
175isotype switching (GO:0045190)2.43098106
176somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43098106
177histone H2A ubiquitination (GO:0033522)2.42711810
178prenylation (GO:0097354)2.42532494
179protein prenylation (GO:0018342)2.42532494
180male meiosis (GO:0007140)2.42206850
181DNA catabolic process, exonucleolytic (GO:0000738)2.41600569
182keratinocyte development (GO:0003334)2.41259990
183phosphorylated carbohydrate dephosphorylation (GO:0046838)2.40857979
184inositol phosphate dephosphorylation (GO:0046855)2.40857979
185C-terminal protein lipidation (GO:0006501)2.40664177
186amino acid salvage (GO:0043102)2.39773677
187L-methionine salvage (GO:0071267)2.39773677
188L-methionine biosynthetic process (GO:0071265)2.39773677
189nucleotide transmembrane transport (GO:1901679)2.38603554
190positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38057995
191positive regulation of protein autophosphorylation (GO:0031954)2.37799759
192histone exchange (GO:0043486)2.36021034
193preassembly of GPI anchor in ER membrane (GO:0016254)2.35013288
194C-terminal protein amino acid modification (GO:0018410)2.34804614
195positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.33753588
196epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32582474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.52812234
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.99528361
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.14651428
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.95857248
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83879741
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.64790167
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.27440359
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.03766085
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37554986
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.26576307
11GATA1_22025678_ChIP-Seq_K562_Human3.15235676
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.89902421
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86758413
14GBX2_23144817_ChIP-Seq_PC3_Human2.74926414
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.72376441
16ZNF274_21170338_ChIP-Seq_K562_Hela2.69750865
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.69085104
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58012796
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55935701
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.44937945
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40657728
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34155430
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33995769
24IGF1R_20145208_ChIP-Seq_DFB_Human2.33845491
25EWS_26573619_Chip-Seq_HEK293_Human2.29575301
26ELK1_19687146_ChIP-ChIP_HELA_Human2.25241984
27TAF15_26573619_Chip-Seq_HEK293_Human2.20749172
28FUS_26573619_Chip-Seq_HEK293_Human2.14979271
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08816818
30P300_19829295_ChIP-Seq_ESCs_Human2.04994744
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02076965
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99238906
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96172009
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.87190143
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86056381
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85639252
37CLOCK_20551151_ChIP-Seq_293T_Human1.79443062
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.73954291
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70704992
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67971389
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67175833
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67012252
43VDR_23849224_ChIP-Seq_CD4+_Human1.64653115
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62085712
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61571966
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59893319
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58014404
48IRF1_19129219_ChIP-ChIP_H3396_Human1.57928747
49ER_23166858_ChIP-Seq_MCF-7_Human1.55153151
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.54837270
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50700220
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47955561
53SMAD4_21799915_ChIP-Seq_A2780_Human1.46994077
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46813986
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46668264
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46509396
57* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45423452
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.45117165
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44955551
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44213794
61BCAT_22108803_ChIP-Seq_LS180_Human1.43737117
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42919719
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.41709869
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39685370
65AR_25329375_ChIP-Seq_VCAP_Human1.37710806
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35995810
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.35844347
68TP53_22573176_ChIP-Seq_HFKS_Human1.33336856
69MYC_18940864_ChIP-ChIP_HL60_Human1.33279060
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.32923689
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31177412
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.30309921
73* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28305420
74* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28305420
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28102412
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.26765342
77TCF4_22108803_ChIP-Seq_LS180_Human1.25728380
78* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25028924
79* CBP_20019798_ChIP-Seq_JUKART_Human1.25028924
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.24978205
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24316879
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24304839
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.23178234
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22259947
85* FOXP3_21729870_ChIP-Seq_TREG_Human1.21622954
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21422010
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21080160
88P53_22387025_ChIP-Seq_ESCs_Mouse1.20291806
89STAT3_23295773_ChIP-Seq_U87_Human1.19665934
90AR_20517297_ChIP-Seq_VCAP_Human1.19278614
91* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19146294
92* FOXA1_25329375_ChIP-Seq_VCAP_Human1.19146294
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18809447
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18482315
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17903559
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17056506
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17051976
98* CDX2_22108803_ChIP-Seq_LS180_Human1.16986217
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16247207
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16119890
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15836965
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15575774
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15126200
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14535782
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.14479732
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.13901933
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11649453
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11446882
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11321548
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10886453
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.10039619
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09962861
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09610792
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09566836
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.09486605
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08332202
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06627913
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06627913
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05469401
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04520402
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03966080
122TCF4_23295773_ChIP-Seq_U87_Human1.03582507
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03303183
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.02264842
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.02143412
126CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01817479
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.00240619
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00111638
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99834589
130HTT_18923047_ChIP-ChIP_STHdh_Human0.99665152
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99361357
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.98786910
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98748813
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98747643
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98582643
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96985219
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95669831
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94481361
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94452636
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88163073
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87087328
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86579376
143IRF8_27001747_Chip-Seq_BMDM_Mouse0.86499673
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.86154297
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83980904
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.83922916
147* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83055812
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82654594
149SOX2_20726797_ChIP-Seq_SW620_Human0.81965115
150CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76701224
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76272130
152GATA4_25053715_ChIP-Seq_YYC3_Human0.75685494
153FOXA2_19822575_ChIP-Seq_HepG2_Human0.74971005
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74208693
155* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.72510257
156ERG_20517297_ChIP-Seq_VCAP_Human0.70843419
157ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70536917
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70352541
159PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69792006
160SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68755888
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68720971
162CJUN_26792858_Chip-Seq_BT549_Human0.68340162
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66795521
164* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65588836
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64940863
166CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64705925
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64069939
168CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63741710
169* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.62630111
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62483806
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.62164828
172* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62064656
173SOX2_27498859_Chip-Seq_STOMACH_Mouse0.61983820
174P53_21459846_ChIP-Seq_SAOS-2_Human0.61907995
175* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.61567682
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61547959
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61165988
178CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60678689
179PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60101112
180STAT1_17558387_ChIP-Seq_HELA_Human0.59439912
181* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.58935365
182* SOX2_19829295_ChIP-Seq_ESCs_Human0.58915712
183* NANOG_19829295_ChIP-Seq_ESCs_Human0.58915712
184BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.58496458
185PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57946198
186VDR_22108803_ChIP-Seq_LS180_Human0.57675202
187EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.57377647
188PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.56923864
189* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.55782124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.22289646
2MP0005360_urolithiasis5.26554453
3MP0005365_abnormal_bile_salt4.85336321
4MP0005085_abnormal_gallbladder_physiolo4.56545674
5MP0008875_abnormal_xenobiotic_pharmacok3.82961647
6MP0003806_abnormal_nucleotide_metabolis3.34427541
7MP0003252_abnormal_bile_duct3.16323331
8MP0008877_abnormal_DNA_methylation3.15884065
9MP0003195_calcinosis3.14306928
10MP0010329_abnormal_lipoprotein_level2.91023548
11MP0005332_abnormal_amino_acid2.80845901
12MP0009840_abnormal_foam_cell2.73559376
13MP0005083_abnormal_biliary_tract2.73481126
14MP0001984_abnormal_olfaction2.69940279
15MP0002102_abnormal_ear_morphology2.54806343
16MP0003191_abnormal_cellular_cholesterol2.39983677
17MP0009046_muscle_twitch2.30120838
18MP0003186_abnormal_redox_activity2.25641484
19MP0008058_abnormal_DNA_repair2.23708391
20MP0002638_abnormal_pupillary_reflex2.22455045
21MP0001666_abnormal_nutrient_absorption2.21792965
22MP0003011_delayed_dark_adaptation2.20201982
23MP0003880_abnormal_central_pattern2.18613370
24MP0006072_abnormal_retinal_apoptosis2.07588444
25MP0002736_abnormal_nociception_after2.07497456
26MP0002138_abnormal_hepatobiliary_system2.05257335
27MP0001529_abnormal_vocalization2.00716762
28MP0005319_abnormal_enzyme/_coenzyme1.92132618
29MP0003787_abnormal_imprinting1.90925765
30MP0005551_abnormal_eye_electrophysiolog1.86736889
31MP0005253_abnormal_eye_physiology1.83669805
32MP0001764_abnormal_homeostasis1.82732701
33MP0005084_abnormal_gallbladder_morpholo1.82527975
34MP0004019_abnormal_vitamin_homeostasis1.82348451
35MP0005075_abnormal_melanosome_morpholog1.79008377
36MP0008872_abnormal_physiological_respon1.77992004
37MP0002118_abnormal_lipid_homeostasis1.77669150
38MP0008438_abnormal_cutaneous_collagen1.72793714
39MP0003122_maternal_imprinting1.72673882
40MP0004142_abnormal_muscle_tone1.70447261
41MP0010368_abnormal_lymphatic_system1.69840257
42MP0001968_abnormal_touch/_nociception1.68695958
43MP0000609_abnormal_liver_physiology1.67835398
44MP0005379_endocrine/exocrine_gland_phen1.67031710
45MP0004147_increased_porphyrin_level1.64993114
46MP0005367_renal/urinary_system_phenotyp1.63768463
47MP0000516_abnormal_urinary_system1.63768463
48MP0006054_spinal_hemorrhage1.61192309
49MP0004215_abnormal_myocardial_fiber1.60932874
50MP0009764_decreased_sensitivity_to1.60707086
51MP0006036_abnormal_mitochondrial_physio1.60343452
52MP0003656_abnormal_erythrocyte_physiolo1.58117990
53MP0000372_irregular_coat_pigmentation1.56700900
54MP0002653_abnormal_ependyma_morphology1.55540034
55MP0005584_abnormal_enzyme/coenzyme_acti1.55399783
56MP0009643_abnormal_urine_homeostasis1.55081066
57MP0006276_abnormal_autonomic_nervous1.54254460
58MP0002938_white_spotting1.52392061
59MP0003718_maternal_effect1.48688789
60MP0005058_abnormal_lysosome_morphology1.48395854
61MP0005410_abnormal_fertilization1.48255838
62MP0005645_abnormal_hypothalamus_physiol1.48033299
63MP0002272_abnormal_nervous_system1.46904543
64MP0009697_abnormal_copulation1.46430941
65MP0005670_abnormal_white_adipose1.46205685
66MP0002909_abnormal_adrenal_gland1.41577429
67MP0006292_abnormal_olfactory_placode1.41327386
68MP0003724_increased_susceptibility_to1.41111443
69MP0005174_abnormal_tail_pigmentation1.40915832
70MP0009745_abnormal_behavioral_response1.39008598
71MP0001485_abnormal_pinna_reflex1.37466889
72MP0002876_abnormal_thyroid_physiology1.37006383
73MP0000749_muscle_degeneration1.34565393
74MP0005636_abnormal_mineral_homeostasis1.33985878
75MP0001542_abnormal_bone_strength1.33117944
76MP0000631_abnormal_neuroendocrine_gland1.33102899
77MP0003121_genomic_imprinting1.32990078
78MP0002163_abnormal_gland_morphology1.31210439
79MP0002090_abnormal_vision1.23571093
80MP0005503_abnormal_tendon_morphology1.23417527
81MP0004043_abnormal_pH_regulation1.23059879
82MP0003136_yellow_coat_color1.22489263
83MP0003786_premature_aging1.21504686
84MP0002837_dystrophic_cardiac_calcinosis1.19512891
85MP0008469_abnormal_protein_level1.19385625
86MP0000015_abnormal_ear_pigmentation1.18478929
87MP0003279_aneurysm1.17233468
88MP0004133_heterotaxia1.16787054
89MP0000569_abnormal_digit_pigmentation1.16480819
90MP0002254_reproductive_system_inflammat1.16378405
91MP0003868_abnormal_feces_composition1.15099520
92MP0001905_abnormal_dopamine_level1.12819775
93MP0008789_abnormal_olfactory_epithelium1.12457065
94MP0008995_early_reproductive_senescence1.11227640
95MP0000647_abnormal_sebaceous_gland1.07831435
96MP0001879_abnormal_lymphatic_vessel1.06473106
97MP0000230_abnormal_systemic_arterial1.06259308
98MP0002095_abnormal_skin_pigmentation1.05454887
99MP0001486_abnormal_startle_reflex1.02661847
100MP0001756_abnormal_urination1.00595922
101MP0000604_amyloidosis1.00126692
102MP0001958_emphysema0.99651606
103MP0002734_abnormal_mechanical_nocicepti0.97903163
104MP0005394_taste/olfaction_phenotype0.97825404
105MP0005499_abnormal_olfactory_system0.97825404
106MP0005187_abnormal_penis_morphology0.97039954
107MP0003436_decreased_susceptibility_to0.96863204
108MP0001970_abnormal_pain_threshold0.96802213
109MP0000598_abnormal_liver_morphology0.96377483
110MP0005376_homeostasis/metabolism_phenot0.96304607
111MP0002064_seizures0.94925691
112MP0001533_abnormal_skeleton_physiology0.94694492
113MP0009763_increased_sensitivity_to0.94530065
114MP0002078_abnormal_glucose_homeostasis0.94474127
115MP0005220_abnormal_exocrine_pancreas0.94332654
116MP0003075_altered_response_to0.93926686
117MP0009780_abnormal_chondrocyte_physiolo0.93488832
118MP0002557_abnormal_social/conspecific_i0.93095940
119MP0009642_abnormal_blood_homeostasis0.90618826
120MP0005164_abnormal_response_to0.89992461
121MP0004885_abnormal_endolymph0.89952371
122MP0000427_abnormal_hair_cycle0.89718263
123MP0010386_abnormal_urinary_bladder0.89541552
124MP0002067_abnormal_sensory_capabilities0.88262707
125MP0004130_abnormal_muscle_cell0.87583519
126MP0001929_abnormal_gametogenesis0.87482217
127MP0006035_abnormal_mitochondrial_morpho0.86537154
128MP0002572_abnormal_emotion/affect_behav0.85354788
129MP0001501_abnormal_sleep_pattern0.85113058
130MP0006082_CNS_inflammation0.83869992
131MP0003890_abnormal_embryonic-extraembry0.83041282
132MP0001853_heart_inflammation0.82987194
133MP0004782_abnormal_surfactant_physiolog0.82925353
134MP0001188_hyperpigmentation0.81797134
135MP0003698_abnormal_male_reproductive0.81214456
136MP0001324_abnormal_eye_pigmentation0.81008554
137MP0002751_abnormal_autonomic_nervous0.80771947
138MP0002210_abnormal_sex_determination0.80422315
139MP0000639_abnormal_adrenal_gland0.80395573
140MP0000653_abnormal_sex_gland0.80080690
141MP0005451_abnormal_body_composition0.80031112
142MP0005334_abnormal_fat_pad0.79555246
143MP0005165_increased_susceptibility_to0.78926243
144MP0005535_abnormal_body_temperature0.78744255
145MP0000358_abnormal_cell_content/0.76700385
146MP0005275_abnormal_skin_tensile0.76549800
147MP0000343_altered_response_to0.76190024
148MP0005595_abnormal_vascular_smooth0.75275779
149MP0000383_abnormal_hair_follicle0.74989225
150MP0005167_abnormal_blood-brain_barrier0.74012333
151MP0003690_abnormal_glial_cell0.73555120
152MP0005166_decreased_susceptibility_to0.72241262
153MP0002332_abnormal_exercise_endurance0.71155970
154MP0000013_abnormal_adipose_tissue0.69681067
155MP0002419_abnormal_innate_immunity0.69331562
156MP0005266_abnormal_metabolism0.67544489
157MP0002136_abnormal_kidney_physiology0.66770330
158MP0009785_altered_susceptibility_to0.64398590
159MP0001845_abnormal_inflammatory_respons0.63804096
160MP0002693_abnormal_pancreas_physiology0.62752318
161MP0004883_abnormal_blood_vessel0.62237815
162MP0002295_abnormal_pulmonary_circulatio0.60592365
163MP0003705_abnormal_hypodermis_morpholog0.59721256
164MP0005647_abnormal_sex_gland0.58615869
165MP0000249_abnormal_blood_vessel0.57835528
166MP0005408_hypopigmentation0.57771442
167MP0005448_abnormal_energy_balance0.56977654
168MP0005646_abnormal_pituitary_gland0.56420634
169MP0005464_abnormal_platelet_physiology0.56115593
170MP0003646_muscle_fatigue0.55330481
171MP0002933_joint_inflammation0.54415897
172MP0001944_abnormal_pancreas_morphology0.54097401
173MP0009384_cardiac_valve_regurgitation0.53685800
174MP0009765_abnormal_xenobiotic_induced0.52327392
175MP0002971_abnormal_brown_adipose0.51768472

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.23814121
2Intrahepatic cholestasis (HP:0001406)4.57726692
3Xanthomatosis (HP:0000991)4.38405378
4Hypoglycemic coma (HP:0001325)4.23712860
5Prolonged partial thromboplastin time (HP:0003645)4.21421228
6Deep venous thrombosis (HP:0002625)4.09584009
7Hypobetalipoproteinemia (HP:0003563)3.86846313
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.84935131
9Ketosis (HP:0001946)3.72844173
10Ketoacidosis (HP:0001993)3.62072299
11Complement deficiency (HP:0004431)3.58374078
12Hyperlipoproteinemia (HP:0010980)3.51459836
13Pancreatic cysts (HP:0001737)3.47594582
14Hypoalphalipoproteinemia (HP:0003233)3.47409907
15Hypolipoproteinemia (HP:0010981)3.46962660
163-Methylglutaconic aciduria (HP:0003535)3.39761558
17Pancreatic fibrosis (HP:0100732)3.39069353
18Hyperammonemia (HP:0001987)3.35071927
19True hermaphroditism (HP:0010459)3.34686814
20Abnormality of the common coagulation pathway (HP:0010990)3.33234575
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.30350490
22Abnormality of the intrinsic pathway (HP:0010989)3.28968915
23Joint hemorrhage (HP:0005261)3.24868489
24Abnormality of fatty-acid metabolism (HP:0004359)3.24109319
25Generalized aminoaciduria (HP:0002909)3.21784552
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19567380
27Molar tooth sign on MRI (HP:0002419)3.18593745
28Abnormality of midbrain morphology (HP:0002418)3.18593745
29Nephronophthisis (HP:0000090)3.14173434
30Medial flaring of the eyebrow (HP:0010747)3.12082216
31Abnormality of methionine metabolism (HP:0010901)3.09787275
32Hypoglycemic seizures (HP:0002173)3.08211263
33Fat malabsorption (HP:0002630)3.05756694
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04764056
35Dicarboxylic aciduria (HP:0003215)3.01363599
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01363599
37Hepatic necrosis (HP:0002605)3.00834873
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.00317558
39Systemic lupus erythematosus (HP:0002725)2.98826890
40Cerebral edema (HP:0002181)2.98097475
41Hyperbilirubinemia (HP:0002904)2.97017884
42Abnormality of complement system (HP:0005339)2.96127222
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.84616436
44Abnormality of the renal cortex (HP:0011035)2.83644033
45Increased hepatocellular lipid droplets (HP:0006565)2.80374946
46Metabolic acidosis (HP:0001942)2.75900423
47Hypercholesterolemia (HP:0003124)2.75861428
48Acute encephalopathy (HP:0006846)2.71857144
49Renal Fanconi syndrome (HP:0001994)2.71088265
50Hyperglycinuria (HP:0003108)2.65324455
51Abnormality of the renal medulla (HP:0100957)2.61434596
52Methylmalonic acidemia (HP:0002912)2.61060907
53Conjugated hyperbilirubinemia (HP:0002908)2.60607791
54Gout (HP:0001997)2.60173594
55Lethargy (HP:0001254)2.59181124
56Hyperglycinemia (HP:0002154)2.58409235
57Hyperinsulinemic hypoglycemia (HP:0000825)2.58145222
58Steatorrhea (HP:0002570)2.57318644
59Abnormality of serine family amino acid metabolism (HP:0010894)2.55439988
60Abnormality of glycine metabolism (HP:0010895)2.55439988
61Myoglobinuria (HP:0002913)2.53430195
62Congenital, generalized hypertrichosis (HP:0004540)2.51926211
63Nephrogenic diabetes insipidus (HP:0009806)2.51237424
64Lipid accumulation in hepatocytes (HP:0006561)2.50785178
65Hepatocellular necrosis (HP:0001404)2.50447005
66Abnormality of the labia minora (HP:0012880)2.50216043
67Abnormality of purine metabolism (HP:0004352)2.48276700
68Abolished electroretinogram (ERG) (HP:0000550)2.47164704
69Intestinal atresia (HP:0011100)2.46361504
70Hypothermia (HP:0002045)2.46332955
71Abnormal mitochondria in muscle tissue (HP:0008316)2.44879898
72Congenital primary aphakia (HP:0007707)2.44666215
73Acute necrotizing encephalopathy (HP:0006965)2.43646806
74Gait imbalance (HP:0002141)2.39101383
75Tubular atrophy (HP:0000092)2.33794690
76Vascular calcification (HP:0004934)2.32913759
77Symptomatic seizures (HP:0011145)2.30085126
78Vomiting (HP:0002013)2.29008659
79Abnormality of proline metabolism (HP:0010907)2.27791071
80Hydroxyprolinuria (HP:0003080)2.27791071
81Abnormal gallbladder morphology (HP:0012437)2.27671918
82Glycosuria (HP:0003076)2.27231978
83Abnormality of urine glucose concentration (HP:0011016)2.27231978
84Median cleft lip (HP:0000161)2.27173524
85Hepatocellular carcinoma (HP:0001402)2.25944718
86Recurrent gram-negative bacterial infections (HP:0005420)2.25105306
87Abnormality of nucleobase metabolism (HP:0010932)2.24962710
88Vacuolated lymphocytes (HP:0001922)2.24952625
89Polyphagia (HP:0002591)2.24027432
90Cholecystitis (HP:0001082)2.20444068
91Abnormal gallbladder physiology (HP:0012438)2.20444068
92Male pseudohermaphroditism (HP:0000037)2.19420676
93Rhabdomyolysis (HP:0003201)2.18937949
94Microvesicular hepatic steatosis (HP:0001414)2.18634045
95Proximal tubulopathy (HP:0000114)2.18202978
96Redundant skin (HP:0001582)2.18092009
97Abnormality of serum amino acid levels (HP:0003112)2.16591014
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16275922
99Abnormality of alanine metabolism (HP:0010916)2.16275922
100Hyperalaninemia (HP:0003348)2.16275922
101Exertional dyspnea (HP:0002875)2.15981705
102Type I transferrin isoform profile (HP:0003642)2.15859009
103Cholelithiasis (HP:0001081)2.15301298
104Mitochondrial inheritance (HP:0001427)2.15241409
105Epidermoid cyst (HP:0200040)2.15225615
106Cardiovascular calcification (HP:0011915)2.14851272
107Brushfield spots (HP:0001088)2.14806245
108Methylmalonic aciduria (HP:0012120)2.12420780
109Oligomenorrhea (HP:0000876)2.10597431
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.09800408
111Opisthotonus (HP:0002179)2.09512386
112Congenital hepatic fibrosis (HP:0002612)2.08894308
113Attenuation of retinal blood vessels (HP:0007843)2.08837545
114Bile duct proliferation (HP:0001408)2.08159672
115Abnormal biliary tract physiology (HP:0012439)2.08159672
116Large for gestational age (HP:0001520)2.08001896
117Abnormality of vitamin B metabolism (HP:0004340)2.07466995
118Reduced antithrombin III activity (HP:0001976)2.07451342
119Genital tract atresia (HP:0001827)2.07001428
120Exercise-induced muscle cramps (HP:0003710)2.06526593
121Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04908769
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04908769
123Mitral stenosis (HP:0001718)2.04246486
124Myocardial infarction (HP:0001658)2.04212651
125Sex reversal (HP:0012245)2.02689412
126Abnormal sex determination (HP:0012244)2.02689412
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02675773
128Abnormal protein N-linked glycosylation (HP:0012347)2.02675773
129Abnormal protein glycosylation (HP:0012346)2.02675773
130Abnormal glycosylation (HP:0012345)2.02675773
131Glomerulonephritis (HP:0000099)2.00866332
132Postaxial foot polydactyly (HP:0001830)1.99461703
133Skin nodule (HP:0200036)1.99324828
134Abnormal drinking behavior (HP:0030082)1.99311793
135Polydipsia (HP:0001959)1.99311793
136Late onset (HP:0003584)1.99218363
137Congenital stationary night blindness (HP:0007642)1.98339976
138Lactic acidosis (HP:0003128)1.97647628
139Increased CSF lactate (HP:0002490)1.97467099
140Optic disc pallor (HP:0000543)1.96751177
141Abnormality of renal resorption (HP:0011038)1.96691723
142Pancreatitis (HP:0001733)1.94960949
143Sensorimotor neuropathy (HP:0007141)1.93494251
144Progressive macrocephaly (HP:0004481)1.92858956
145Vaginal atresia (HP:0000148)1.92538269
146Hemiparesis (HP:0001269)1.92247540
147Atonic seizures (HP:0010819)1.91600348
148Neuroendocrine neoplasm (HP:0100634)1.90729199
149Epiphyseal stippling (HP:0010655)1.89981223
150Esophageal neoplasm (HP:0100751)1.89293417
151Neoplasm of head and neck (HP:0012288)1.89293417
152Hyperglycemia (HP:0003074)1.89189286
153Elevated hepatic transaminases (HP:0002910)1.88562105
154Furrowed tongue (HP:0000221)1.87617956
155Cystic liver disease (HP:0006706)1.87425057
156Abnormal ciliary motility (HP:0012262)1.86933617
157Exercise-induced myalgia (HP:0003738)1.86491640
158Decreased central vision (HP:0007663)1.85878001
159Postaxial hand polydactyly (HP:0001162)1.85524960
160Amyloidosis (HP:0011034)1.85236541
161Short tibia (HP:0005736)1.84572403
162Spontaneous abortion (HP:0005268)1.84174171
163Sclerocornea (HP:0000647)1.83994877
164Renal cortical cysts (HP:0000803)1.82120639
165Respiratory failure (HP:0002878)1.81839477
166Hypomagnesemia (HP:0002917)1.81724947
167Abnormal rod and cone electroretinograms (HP:0008323)1.79397579
168Pancreatic islet-cell hyperplasia (HP:0004510)1.78448309
169Poor suck (HP:0002033)1.76730657
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.76415260
171Occipital encephalocele (HP:0002085)1.75610619
172Lissencephaly (HP:0001339)1.72872917
173Anencephaly (HP:0002323)1.72519039
174Aplasia/Hypoplasia of the fovea (HP:0008060)1.72402492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.11031539
2INSRR4.91329610
3ERN13.81346235
4TNIK2.80706321
5TGFBR22.55112039
6MAP4K22.47672561
7TRIM282.44832778
8PINK12.28657964
9IRAK32.11928941
10EIF2AK11.96596277
11TIE11.96036363
12PDK31.89834589
13PDK41.89834589
14OBSCN1.89401050
15MAP3K141.81239263
16PIK3CG1.81146737
17FLT31.77082882
18MYLK1.70955517
19PLK21.69208914
20TAOK31.66241386
21MAP2K31.61332581
22ERBB31.57842809
23MAP3K31.56651086
24PLK31.55870684
25TYK21.55353150
26FGFR41.54140155
27MAP3K121.51756174
28NME11.51408556
29TBK11.51337282
30FER1.50457118
31SIK11.48123563
32WNK31.45798436
33MUSK1.41161304
34KDR1.40352801
35MKNK21.38373270
36BCR1.35432983
37KIT1.32506767
38VRK11.31112378
39BRSK21.30317532
40PDK21.23620723
41PNCK1.20182536
42NME21.19607644
43PBK1.17962469
44MAP3K41.17445134
45MAP3K21.15375098
46PIM21.13715880
47MST1R1.11689340
48FGFR21.11615608
49MAPK121.10982959
50OXSR11.09826201
51CAMKK21.09711974
52MAPK151.08698330
53STK31.07798789
54WEE11.07608385
55MAP2K41.07049857
56STK161.06718561
57NEK91.06701212
58MAPK131.06421503
59NEK11.06322138
60BUB11.04855333
61ABL21.04779502
62CSNK1G11.02929959
63MKNK11.02574930
64EPHA31.01114268
65EPHB20.95980019
66CSNK1G20.95591764
67MAP2K60.94826589
68BMPR1B0.94805937
69NLK0.94247919
70PAK30.93536569
71VRK20.91267519
72TXK0.90327453
73TSSK60.90050190
74CSNK1G30.89080439
75JAK30.88325379
76WNK40.83760940
77FES0.83649661
78TEC0.83648907
79CAMK1D0.83008436
80ERBB40.82330682
81ZAK0.80092762
82IKBKE0.79003889
83TAOK20.76992133
84ACVR1B0.76724247
85CASK0.76311501
86MET0.73113659
87ADRBK10.72481366
88DYRK20.72371576
89IRAK10.71586951
90MINK10.70199878
91STK390.69752969
92JAK10.69154667
93TGFBR10.68522906
94BRAF0.68263704
95STK38L0.68006187
96ARAF0.67111467
97SIK30.67037717
98ADRBK20.66735623
99MAPKAPK30.66436022
100BMX0.66247663
101PLK40.64889021
102EIF2AK30.64791036
103MST40.64725566
104DYRK1B0.63536122
105TTN0.62306367
106GRK70.61423332
107TRPM70.60900388
108MAPK110.60596704
109BMPR20.59973914
110PRKG20.59818129
111BLK0.59255414
112FRK0.57629356
113TESK10.56861869
114MAP3K50.56758309
115DYRK30.56318349
116MAPK40.55523155
117MAP3K70.55035660
118PLK10.54865038
119MAPK70.53933993
120GRK50.52869779
121PIK3CA0.52868505
122MAP2K20.52511294
123JAK20.52428808
124GRK10.51671712
125DAPK20.50506608
126CAMK2A0.50029468
127ILK0.49339986
128IKBKB0.49333319
129MAP3K110.49233885
130IRAK40.49205358
131IGF1R0.48292060
132MAP2K10.47871875
133PRKCD0.47848495
134STK40.47782519
135MAP2K70.47519787
136SRPK10.47147702
137ZAP700.46834134
138CSNK1A1L0.46567121
139MAP3K10.45938562
140CDK190.44038740
141YES10.43841871
142CSF1R0.43786073
143PRKG10.43353922
144TLK10.41526593
145PTK2B0.41302474
146CCNB10.40464085
147EIF2AK20.40344878
148NUAK10.40167751
149PHKG20.40130950
150PHKG10.40130950
151PRKACG0.38394025
152PRKACA0.38158199
153PRKCE0.38136500
154SGK20.37798990
155PASK0.37455167
156PRKCG0.37272148
157PRKCI0.36302364
158CSNK1A10.35448089
159NTRK30.34152359
160PRKCQ0.32513150
161PRKACB0.32484288
162RPS6KA50.30572915
163CAMK2D0.29676951

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84509427
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56170866
3Fatty acid degradation_Homo sapiens_hsa000712.53951177
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52178434
5Complement and coagulation cascades_Homo sapiens_hsa046102.48823847
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30844307
7Arginine biosynthesis_Homo sapiens_hsa002202.29325026
8Peroxisome_Homo sapiens_hsa041462.23010349
9Tryptophan metabolism_Homo sapiens_hsa003802.22017442
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20262869
11RNA polymerase_Homo sapiens_hsa030202.19968128
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19643252
13Propanoate metabolism_Homo sapiens_hsa006402.19337654
14Nitrogen metabolism_Homo sapiens_hsa009102.13574846
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12607263
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11347686
17Basal transcription factors_Homo sapiens_hsa030222.11004540
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10923977
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01614113
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90089009
21Sulfur metabolism_Homo sapiens_hsa009201.88650938
22Chemical carcinogenesis_Homo sapiens_hsa052041.87556457
23Fatty acid metabolism_Homo sapiens_hsa012121.85833906
24Phototransduction_Homo sapiens_hsa047441.85574225
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85302373
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82253166
27Butanoate metabolism_Homo sapiens_hsa006501.78858108
28PPAR signaling pathway_Homo sapiens_hsa033201.78630485
29Pyruvate metabolism_Homo sapiens_hsa006201.74071511
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.72968576
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71393800
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70618964
33Protein export_Homo sapiens_hsa030601.69144255
34Staphylococcus aureus infection_Homo sapiens_hsa051501.57900464
35Starch and sucrose metabolism_Homo sapiens_hsa005001.56179421
36Selenocompound metabolism_Homo sapiens_hsa004501.55866775
37Non-homologous end-joining_Homo sapiens_hsa034501.54114257
38Homologous recombination_Homo sapiens_hsa034401.50223444
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48722852
40Histidine metabolism_Homo sapiens_hsa003401.47935063
41beta-Alanine metabolism_Homo sapiens_hsa004101.45262833
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.43021561
43Caffeine metabolism_Homo sapiens_hsa002321.42901206
44Carbon metabolism_Homo sapiens_hsa012001.40773539
45RNA degradation_Homo sapiens_hsa030181.37369641
46Phenylalanine metabolism_Homo sapiens_hsa003601.35577284
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.35218501
48Regulation of autophagy_Homo sapiens_hsa041401.33915083
49Retinol metabolism_Homo sapiens_hsa008301.32676823
50Fatty acid elongation_Homo sapiens_hsa000621.28694732
51Mismatch repair_Homo sapiens_hsa034301.28535998
52Folate biosynthesis_Homo sapiens_hsa007901.26955563
53Fanconi anemia pathway_Homo sapiens_hsa034601.26821725
54Oxidative phosphorylation_Homo sapiens_hsa001901.26504086
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24860844
56Biosynthesis of amino acids_Homo sapiens_hsa012301.18516865
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18055847
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17620487
59Tyrosine metabolism_Homo sapiens_hsa003501.14897466
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14075286
61Circadian rhythm_Homo sapiens_hsa047101.13912665
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13045293
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.12763889
64One carbon pool by folate_Homo sapiens_hsa006701.11151525
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09405072
66Galactose metabolism_Homo sapiens_hsa000521.08428741
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07903032
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07404740
69Glutathione metabolism_Homo sapiens_hsa004801.07059522
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05914533
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04915860
72Bile secretion_Homo sapiens_hsa049761.03741563
73GABAergic synapse_Homo sapiens_hsa047271.02654524
74Purine metabolism_Homo sapiens_hsa002301.00351247
75Fat digestion and absorption_Homo sapiens_hsa049750.99289543
76ABC transporters_Homo sapiens_hsa020100.96856254
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95301297
78Arginine and proline metabolism_Homo sapiens_hsa003300.95083456
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94204848
80Parkinsons disease_Homo sapiens_hsa050120.93955479
81Fructose and mannose metabolism_Homo sapiens_hsa000510.91648014
82Steroid biosynthesis_Homo sapiens_hsa001000.90590302
83Vitamin digestion and absorption_Homo sapiens_hsa049770.90570270
84Nicotine addiction_Homo sapiens_hsa050330.90013418
85Pentose phosphate pathway_Homo sapiens_hsa000300.85649245
86Sulfur relay system_Homo sapiens_hsa041220.81876293
87Pyrimidine metabolism_Homo sapiens_hsa002400.78208281
88Glycerolipid metabolism_Homo sapiens_hsa005610.76960103
89Insulin secretion_Homo sapiens_hsa049110.76892512
90Nucleotide excision repair_Homo sapiens_hsa034200.75962392
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75398585
92Serotonergic synapse_Homo sapiens_hsa047260.72318420
93Metabolic pathways_Homo sapiens_hsa011000.69833970
94Ether lipid metabolism_Homo sapiens_hsa005650.69450609
95Fatty acid biosynthesis_Homo sapiens_hsa000610.67643344
96Morphine addiction_Homo sapiens_hsa050320.66938422
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61361790
98Circadian entrainment_Homo sapiens_hsa047130.61050517
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60953021
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60899825
101RNA transport_Homo sapiens_hsa030130.60112043
102Alzheimers disease_Homo sapiens_hsa050100.59732980
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59558179
104Oocyte meiosis_Homo sapiens_hsa041140.58029356
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57632996
106Lysosome_Homo sapiens_hsa041420.56052341
107Synaptic vesicle cycle_Homo sapiens_hsa047210.55373150
108Olfactory transduction_Homo sapiens_hsa047400.55355259
109Legionellosis_Homo sapiens_hsa051340.48629356
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.48118214
111Other glycan degradation_Homo sapiens_hsa005110.47305594
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.47218601
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47115308
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46791650
115Dopaminergic synapse_Homo sapiens_hsa047280.46687528
116Taste transduction_Homo sapiens_hsa047420.45189817
117Mineral absorption_Homo sapiens_hsa049780.44364443
118Vitamin B6 metabolism_Homo sapiens_hsa007500.43337142
119Alcoholism_Homo sapiens_hsa050340.42768787
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41837716
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41405843
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40150850
123Vibrio cholerae infection_Homo sapiens_hsa051100.39786268
124Sphingolipid metabolism_Homo sapiens_hsa006000.38320458
125Collecting duct acid secretion_Homo sapiens_hsa049660.38152549
126Ribosome_Homo sapiens_hsa030100.36780999
127Huntingtons disease_Homo sapiens_hsa050160.36649974
128Proteasome_Homo sapiens_hsa030500.36001392
129Type I diabetes mellitus_Homo sapiens_hsa049400.35969746
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35651983
131Prion diseases_Homo sapiens_hsa050200.35116025
132N-Glycan biosynthesis_Homo sapiens_hsa005100.34335002
133Phagosome_Homo sapiens_hsa041450.32771501
134Hedgehog signaling pathway_Homo sapiens_hsa043400.32091805
135Arachidonic acid metabolism_Homo sapiens_hsa005900.31879887
136Lysine degradation_Homo sapiens_hsa003100.30020614
137Rheumatoid arthritis_Homo sapiens_hsa053230.26318839
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.25703648
139Protein digestion and absorption_Homo sapiens_hsa049740.24550532
140Cardiac muscle contraction_Homo sapiens_hsa042600.22517649
141Insulin resistance_Homo sapiens_hsa049310.21902823
142Glucagon signaling pathway_Homo sapiens_hsa049220.18320261
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17053102
144Linoleic acid metabolism_Homo sapiens_hsa005910.16183112
145Malaria_Homo sapiens_hsa051440.12655214
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10409958
147Renin-angiotensin system_Homo sapiens_hsa046140.09408484

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