CH25H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact8.15764421
2modulation by symbiont of host immune response (GO:0052553)8.15764421
3positive regulation by symbiont of host defense response (GO:0052509)8.15764421
4modulation by symbiont of host defense response (GO:0052031)8.15764421
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:008.15764421
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:08.15764421
7response to peptidoglycan (GO:0032494)5.91022668
8macrophage activation involved in immune response (GO:0002281)5.69159519
9response to host immune response (GO:0052572)5.45419110
10response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.45419110
11microglial cell activation (GO:0001774)5.34112218
12cellular response to interferon-alpha (GO:0035457)5.23036976
13positive regulation of interferon-alpha production (GO:0032727)5.12569083
14neutrophil activation involved in immune response (GO:0002283)5.00215184
15adhesion of symbiont to host cell (GO:0044650)4.90041045
16virion attachment to host cell (GO:0019062)4.90041045
17response to host (GO:0075136)4.86023960
18response to host defenses (GO:0052200)4.86023960
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.86023960
20regulation of interferon-alpha production (GO:0032647)4.84970617
21positive regulation of chemokine biosynthetic process (GO:0045080)4.82721607
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.72527894
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.63340788
24regulation of interferon-beta biosynthetic process (GO:0045357)4.47791072
25response to interferon-alpha (GO:0035455)4.43460505
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39904047
27cellular response to type I interferon (GO:0071357)4.30594614
28type I interferon signaling pathway (GO:0060337)4.30594614
29response to type I interferon (GO:0034340)4.29976762
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27634300
31positive regulation of interferon-beta production (GO:0032728)4.12101887
32regulation of mononuclear cell migration (GO:0071675)4.10037062
33positive regulation of toll-like receptor signaling pathway (GO:0034123)4.09984099
34eosinophil chemotaxis (GO:0048245)4.08801102
35positive regulation of heat generation (GO:0031652)4.06124013
36adhesion of symbiont to host (GO:0044406)4.05416919
37lymphocyte chemotaxis (GO:0048247)4.04205852
38immunoglobulin mediated immune response (GO:0016064)4.01487094
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.01029926
40macrophage activation (GO:0042116)3.96858526
41regulation of fever generation (GO:0031620)3.95832589
42regulation of chemokine biosynthetic process (GO:0045073)3.84530402
43response to muramyl dipeptide (GO:0032495)3.80660068
44detection of molecule of bacterial origin (GO:0032490)3.80526936
45positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.79023002
46monocyte chemotaxis (GO:0002548)3.78309210
47myeloid cell activation involved in immune response (GO:0002275)3.75350953
48negative regulation of viral genome replication (GO:0045071)3.69447662
49granulocyte activation (GO:0036230)3.69137330
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67208831
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67208831
52regulation of T-helper 2 cell differentiation (GO:0045628)3.66628440
53positive regulation of macrophage cytokine production (GO:0060907)3.63859926
54regulation of vitamin D biosynthetic process (GO:0060556)3.60204731
55hydrogen peroxide biosynthetic process (GO:0050665)3.58742478
56cellular extravasation (GO:0045123)3.58544641
57eosinophil migration (GO:0072677)3.55198710
58positive regulation of cellular amide metabolic process (GO:0034250)3.53880949
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.53796268
60I-kappaB phosphorylation (GO:0007252)3.50631322
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.49603700
62regulation of T-helper 1 cell differentiation (GO:0045625)3.48926386
63antigen processing and presentation of endogenous antigen (GO:0019883)3.43350868
64positive regulation of natural killer cell differentiation (GO:0032825)3.42261278
65negative regulation of interleukin-17 production (GO:0032700)3.41310925
66regulation of hypersensitivity (GO:0002883)3.39819782
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.38564515
68cellular response to exogenous dsRNA (GO:0071360)3.37005892
69positive regulation of antigen processing and presentation (GO:0002579)3.33813666
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.30833712
71regulation of interleukin-8 biosynthetic process (GO:0045414)3.30328465
72respiratory burst (GO:0045730)3.30028288
73regulation of podosome assembly (GO:0071801)3.29841234
74T cell migration (GO:0072678)3.29723970
75positive regulation of lymphocyte migration (GO:2000403)3.28153997
76interferon-gamma-mediated signaling pathway (GO:0060333)3.24749928
77amino sugar catabolic process (GO:0046348)3.24415905
78decidualization (GO:0046697)3.21862261
79positive regulation of type 2 immune response (GO:0002830)3.20888534
80positive regulation of NF-kappaB import into nucleus (GO:0042346)3.20052739
81neutrophil activation (GO:0042119)3.19810995
82positive regulation of chemokine production (GO:0032722)3.17341233
83keratan sulfate catabolic process (GO:0042340)3.14285698
84cellular response to interferon-beta (GO:0035458)3.12719064
85apoptotic cell clearance (GO:0043277)3.12451234
86reactive oxygen species biosynthetic process (GO:1903409)3.11747032
87regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10438638
88regulation of apoptotic cell clearance (GO:2000425)3.08932382
89negative regulation of growth of symbiont in host (GO:0044130)3.07006842
90negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07006842
91modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07006842
92regulation of growth of symbiont in host (GO:0044126)3.07006842
93superoxide anion generation (GO:0042554)3.05795586
94regulation of heat generation (GO:0031650)3.04537109
95negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02134778
96oligosaccharide catabolic process (GO:0009313)3.02026986
97glycosphingolipid catabolic process (GO:0046479)3.01465287
98negative regulation of interleukin-12 production (GO:0032695)2.98748931
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98389880
100B cell mediated immunity (GO:0019724)2.95151850
101myeloid dendritic cell differentiation (GO:0043011)2.94175712
102positive regulation of interleukin-12 production (GO:0032735)2.93497399
103barbed-end actin filament capping (GO:0051016)2.93430521
104regulation of interleukin-17 production (GO:0032660)2.92362257
105regulation of vitamin metabolic process (GO:0030656)2.92323329
106regulation of interferon-beta production (GO:0032648)2.89748367
107positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.89643490
108negative regulation of lipid storage (GO:0010888)2.89508257
109positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89147090
110regulation of interferon-gamma biosynthetic process (GO:0045072)2.88014332
111regulation of macrophage cytokine production (GO:0010935)2.87552535
112interleukin-6-mediated signaling pathway (GO:0070102)2.87033916
113cellular response to virus (GO:0098586)2.87024449
114regulation of type 2 immune response (GO:0002828)2.87008195
115regulation of antigen processing and presentation (GO:0002577)2.86684548
116positive regulation of nitric oxide biosynthetic process (GO:0045429)2.85974599
117regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.85531651
118cellular response to lipopolysaccharide (GO:0071222)2.84598426
119response to interferon-beta (GO:0035456)2.81929686
120positive regulation of interleukin-6 production (GO:0032755)2.81884662
121positive regulation of monocyte chemotaxis (GO:0090026)2.81388838
122cellular response to molecule of bacterial origin (GO:0071219)2.80316094
123positive regulation of cAMP-mediated signaling (GO:0043950)2.79997878
124cellular response to thyroid hormone stimulus (GO:0097067)2.77855294
125glucosamine-containing compound catabolic process (GO:1901072)2.75881680
126positive regulation of acute inflammatory response (GO:0002675)2.75217620
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72777708
128glycolipid catabolic process (GO:0019377)2.68609011
129regulation of chemokine-mediated signaling pathway (GO:0070099)2.67195190
130cellular response to ethanol (GO:0071361)2.66930342
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61380945
132negative regulation of type 2 immune response (GO:0002829)2.60259658
133regulation of chronic inflammatory response (GO:0002676)2.59619364
134positive regulation of gamma-delta T cell activation (GO:0046645)2.59463800
135regulation of immunoglobulin secretion (GO:0051023)2.58283255
136positive regulation of cholesterol efflux (GO:0010875)2.56112767
137adenosine receptor signaling pathway (GO:0001973)2.55660844
138branching involved in labyrinthine layer morphogenesis (GO:0060670)2.54774032
139mature B cell differentiation involved in immune response (GO:0002313)2.54222011
140regulation of monocyte differentiation (GO:0045655)2.53951511
141regulation of macrophage chemotaxis (GO:0010758)2.51825161
142positive regulation of phagocytosis (GO:0050766)2.50546191
143regulation of vascular endothelial growth factor production (GO:0010574)2.49464267
144regulation of cholesterol storage (GO:0010885)2.47305662
145pinocytosis (GO:0006907)2.46840783
146positive regulation of bone remodeling (GO:0046852)2.46751348
147positive regulation of bone resorption (GO:0045780)2.46751348
148myeloid dendritic cell activation (GO:0001773)2.45585896
149osteoclast differentiation (GO:0030316)2.44831638
150regulation of germinal center formation (GO:0002634)2.44766084
151positive regulation of T-helper cell differentiation (GO:0045624)2.44169149
152regulation of nitric oxide biosynthetic process (GO:0045428)2.42918539
153positive regulation of extracellular matrix organization (GO:1903055)2.42685167
154regulation of inflammatory response to antigenic stimulus (GO:0002861)2.41409336
155regulation of axon regeneration (GO:0048679)2.38275608
156regulation of neuron projection regeneration (GO:0070570)2.38275608
157iron ion import (GO:0097286)2.37419747
158ceramide catabolic process (GO:0046514)2.37057418
159regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.36435802
160regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.35536219
161positive regulation of tissue remodeling (GO:0034105)2.35313810
162negative regulation of granulocyte differentiation (GO:0030853)2.34848546
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34668478
164granulocyte chemotaxis (GO:0071621)2.31151201
165negative regulation of leukocyte chemotaxis (GO:0002689)2.31039956
166regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.29304120
167dendritic cell differentiation (GO:0097028)2.28922810
168positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.28543729
169cellular response to interferon-gamma (GO:0071346)2.26571229
170regulation of T cell tolerance induction (GO:0002664)2.24987984
171regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23235175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.40302060
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.67579133
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.76104313
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.06360856
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.25734568
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82785299
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71802414
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56298394
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47974289
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.41595786
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.29846643
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.27779164
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14347153
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71348091
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.58146127
16GATA1_22025678_ChIP-Seq_K562_Human2.39536697
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37217009
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36415494
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35723072
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30251404
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26447227
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98284453
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96212817
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94923259
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88506780
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.71143020
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69808708
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69161192
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67547040
30VDR_24787735_ChIP-Seq_THP-1_Human1.64794763
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59330167
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.56632724
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55564514
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50415656
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48582238
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46763052
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43347934
38* PU_27001747_Chip-Seq_BMDM_Mouse1.41343663
39VDR_24763502_ChIP-Seq_THP-1_Human1.40844389
40SPI1_23547873_ChIP-Seq_NB4_Human1.39894083
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38610866
42SOX2_20726797_ChIP-Seq_SW620_Human1.35422756
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33395151
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30186273
45SPI1_23127762_ChIP-Seq_K562_Human1.29596868
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28736989
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28486491
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28077685
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25503504
50CJUN_26792858_Chip-Seq_BT549_Human1.25409763
51RUNX_20019798_ChIP-Seq_JUKART_Human1.20214236
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18875823
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18875823
54* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18839675
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14809268
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12036299
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10303230
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06935914
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06059984
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05766770
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05381413
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.04793254
63MYB_26560356_Chip-Seq_TH2_Human1.02648606
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.01544603
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00973666
66MAF_26560356_Chip-Seq_TH1_Human1.00430901
67ELK3_25401928_ChIP-Seq_HUVEC_Human0.97760991
68ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97739145
69EGR1_19032775_ChIP-ChIP_M12_Human0.96420679
70* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95916070
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95847789
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95847789
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.94972103
74* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94727583
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94350941
76SCL_19346495_ChIP-Seq_HPC-7_Human0.94180815
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92947759
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92538834
79STAT1_20625510_ChIP-Seq_HELA_Human0.92500665
80* GATA3_26560356_Chip-Seq_TH2_Human0.92407065
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91449511
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91292658
83* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90638742
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90392287
85* TBX20_22328084_ChIP-Seq_HEART_Mouse0.89747956
86* TBX20_22080862_ChIP-Seq_HEART_Mouse0.89747956
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88981505
88MYB_26560356_Chip-Seq_TH1_Human0.88898121
89TP53_16413492_ChIP-PET_HCT116_Human0.87938802
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87266559
91* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86605110
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86065259
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85577539
94* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84772445
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83472970
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.82267890
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.81434113
98* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79504695
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.78546575
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78352145
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76605071
102TP53_18474530_ChIP-ChIP_U2OS_Human0.76317633
103LXR_22292898_ChIP-Seq_THP-1_Human0.76125850
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76011601
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75622628
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75405082
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74922563
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.74843008
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74292007
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74056497
111* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.73958974
112CLOCK_20551151_ChIP-Seq_293T_Human0.73570528
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70759614
114GATA1_19941826_ChIP-Seq_K562_Human0.69792687
115GATA3_27048872_Chip-Seq_THYMUS_Human0.69649671
116GATA2_19941826_ChIP-Seq_K562_Human0.68288579
117VDR_21846776_ChIP-Seq_THP-1_Human0.68156109
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65257723
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.62367949
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62256424
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61090104
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.60362530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.44390734
2MP0003436_decreased_susceptibility_to4.13731211
3MP0009785_altered_susceptibility_to3.92284464
4MP0006082_CNS_inflammation3.79362114
5MP0003724_increased_susceptibility_to3.53462898
6MP0001835_abnormal_antigen_presentation3.40813537
7MP0002148_abnormal_hypersensitivity_rea3.40175161
8MP0004510_myositis3.10293463
9MP0002419_abnormal_innate_immunity2.98623540
10MP0005000_abnormal_immune_tolerance2.96348036
11MP0005058_abnormal_lysosome_morphology2.95466690
12MP0005025_abnormal_response_to2.71045251
13MP0008438_abnormal_cutaneous_collagen2.69051621
14MP0005387_immune_system_phenotype2.61011770
15MP0001790_abnormal_immune_system2.61011770
16MP0001533_abnormal_skeleton_physiology2.49986872
17MP0009764_decreased_sensitivity_to2.35888269
18MP0009840_abnormal_foam_cell2.29185344
19MP0002452_abnormal_antigen_presenting2.28520945
20MP0003172_abnormal_lysosome_physiology2.18453608
21MP0002723_abnormal_immune_serum2.18199674
22MP0003075_altered_response_to2.09442882
23MP0001542_abnormal_bone_strength2.07319380
24MP0001800_abnormal_humoral_immune2.06279557
25MP0009278_abnormal_bone_marrow2.04680379
26MP0000685_abnormal_immune_system2.01555377
27MP0005503_abnormal_tendon_morphology2.01302917
28MP0004947_skin_inflammation2.00739310
29MP0003329_amyloid_beta_deposits1.99913165
30MP0000343_altered_response_to1.94919360
31MP0003448_altered_tumor_morphology1.87614048
32MP0001853_heart_inflammation1.79514713
33MP0001819_abnormal_immune_cell1.75800679
34MP0000604_amyloidosis1.72124303
35MP0008469_abnormal_protein_level1.71769001
36MP0002420_abnormal_adaptive_immunity1.71533164
37MP0003690_abnormal_glial_cell1.62666120
38MP0001845_abnormal_inflammatory_respons1.61960645
39MP0002998_abnormal_bone_remodeling1.59785421
40MP0005671_abnormal_response_to1.58484199
41MP0002405_respiratory_system_inflammati1.55630823
42MP0005164_abnormal_response_to1.55517887
43MP0005464_abnormal_platelet_physiology1.55278245
44MP0005166_decreased_susceptibility_to1.55275847
45MP0003705_abnormal_hypodermis_morpholog1.51243219
46MP0003195_calcinosis1.48632811
47MP0005595_abnormal_vascular_smooth1.46450273
48MP0003191_abnormal_cellular_cholesterol1.41182578
49MP0005390_skeleton_phenotype1.40209160
50MP0005167_abnormal_blood-brain_barrier1.37355598
51MP0002254_reproductive_system_inflammat1.36911556
52MP0003300_gastrointestinal_ulcer1.36375669
53MP0003950_abnormal_plasma_membrane1.33105833
54MP0005397_hematopoietic_system_phenotyp1.30387851
55MP0001545_abnormal_hematopoietic_system1.30387851
56MP0010155_abnormal_intestine_physiology1.28952846
57MP0005275_abnormal_skin_tensile1.28549964
58MP0006054_spinal_hemorrhage1.24521227
59MP0003828_pulmonary_edema1.21767222
60MP0009333_abnormal_splenocyte_physiolog1.20724537
61MP0001851_eye_inflammation1.20046998
62MP0004858_abnormal_nervous_system1.19845449
63MP0002006_tumorigenesis1.17242208
64MP0000858_altered_metastatic_potential1.14522359
65MP0000716_abnormal_immune_system1.12636405
66MP0003279_aneurysm1.11396841
67MP0004782_abnormal_surfactant_physiolog1.08674290
68MP0005076_abnormal_cell_differentiation1.06794409
69MP0003656_abnormal_erythrocyte_physiolo1.05287969
70MP0005023_abnormal_wound_healing1.04461758
71MP0003091_abnormal_cell_migration1.03352361
72MP0005310_abnormal_salivary_gland1.00554327
73MP0003566_abnormal_cell_adhesion1.00336941
74MP0009763_increased_sensitivity_to0.99162089
75MP0003453_abnormal_keratinocyte_physiol0.98603853
76MP0002933_joint_inflammation0.96566501
77MP0003634_abnormal_glial_cell0.96566288
78MP0001958_emphysema0.95391667
79MP0002090_abnormal_vision0.91899814
80MP0010368_abnormal_lymphatic_system0.91692876
81MP0005508_abnormal_skeleton_morphology0.91344493
82MP0005647_abnormal_sex_gland0.91243893
83MP0002277_abnormal_respiratory_mucosa0.89948168
84MP0002398_abnormal_bone_marrow0.89690521
85MP0005377_hearing/vestibular/ear_phenot0.87655539
86MP0003878_abnormal_ear_physiology0.87655539
87MP0010307_abnormal_tumor_latency0.87265644
88MP0002971_abnormal_brown_adipose0.86928632
89MP0001243_abnormal_dermal_layer0.86646864
90MP0002295_abnormal_pulmonary_circulatio0.85094247
91MP0008874_decreased_physiological_sensi0.84995341
92MP0000689_abnormal_spleen_morphology0.84688297
93MP0002429_abnormal_blood_cell0.83980949
94MP0000249_abnormal_blood_vessel0.83332481
95MP0002896_abnormal_bone_mineralization0.83323424
96MP0003186_abnormal_redox_activity0.83188074
97MP0001879_abnormal_lymphatic_vessel0.82721157
98MP0005083_abnormal_biliary_tract0.80806044
99MP0005257_abnormal_intraocular_pressure0.80524312
100MP0003879_abnormal_hair_cell0.80486798
101MP0005165_increased_susceptibility_to0.80320319
102MP0000767_abnormal_smooth_muscle0.77317042
103MP0008004_abnormal_stomach_pH0.75801663
104MP0009765_abnormal_xenobiotic_induced0.75205889
105MP0002166_altered_tumor_susceptibility0.74135511
106MP0002332_abnormal_exercise_endurance0.73545577
107MP0004883_abnormal_blood_vessel0.73135471
108MP0003795_abnormal_bone_structure0.72071076
109MP0000465_gastrointestinal_hemorrhage0.68965209
110MP0009115_abnormal_fat_cell0.68854560
111MP0001501_abnormal_sleep_pattern0.67735135
112MP0002722_abnormal_immune_system0.67020501
113MP0005365_abnormal_bile_salt0.66780487
114MP0001756_abnormal_urination0.66470895
115MP0009384_cardiac_valve_regurgitation0.66233185
116MP0003045_fibrosis0.64445471
117MP0010352_gastrointestinal_tract_polyps0.64249913
118MP0002139_abnormal_hepatobiliary_system0.63994237
119MP0000920_abnormal_myelination0.61465367
120MP0002136_abnormal_kidney_physiology0.57591847
121MP0003941_abnormal_skin_development0.57200080
122MP0004272_abnormal_basement_membrane0.57115279
123MP0008873_increased_physiological_sensi0.54862123
124MP0004808_abnormal_hematopoietic_stem0.54398638

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.53571891
2Recurrent abscess formation (HP:0002722)6.52217070
3Recurrent bacterial skin infections (HP:0005406)6.03763727
4Recurrent gram-negative bacterial infections (HP:0005420)5.70327448
5Systemic lupus erythematosus (HP:0002725)5.37802216
6Abnormality of macrophages (HP:0004311)5.21875242
7Autoimmune thrombocytopenia (HP:0001973)5.13347105
8Increased cerebral lipofuscin (HP:0011813)4.79559916
9Mediastinal lymphadenopathy (HP:0100721)4.64704937
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.59672526
11Elevated erythrocyte sedimentation rate (HP:0003565)4.40294780
12Axonal loss (HP:0003447)4.31210165
13Basal ganglia calcification (HP:0002135)3.95890417
14Glomerulonephritis (HP:0000099)3.82732893
15Thick nail (HP:0001805)3.82027136
16Vacuolated lymphocytes (HP:0001922)3.81348551
17Gingivitis (HP:0000230)3.80292933
18Disinhibition (HP:0000734)3.80137431
19Increased IgM level (HP:0003496)3.77346894
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.54960185
21Prostate neoplasm (HP:0100787)3.47865273
22Recurrent skin infections (HP:0001581)3.44395501
23Mutism (HP:0002300)3.35825070
24Stomatitis (HP:0010280)3.34428087
25Orchitis (HP:0100796)3.29283593
26Vasculitis (HP:0002633)3.21468446
27Dysostosis multiplex (HP:0000943)3.19875479
28Spondylolisthesis (HP:0003302)3.13074270
29Myocardial infarction (HP:0001658)3.09605067
30Myositis (HP:0100614)3.09135701
31Tetraparesis (HP:0002273)3.06017864
32Nephritis (HP:0000123)2.95407489
33Obstructive lung disease (HP:0006536)2.92063781
34Chronic obstructive pulmonary disease (HP:0006510)2.92063781
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90885207
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.88396615
37Osteolytic defects of the hand bones (HP:0009699)2.88396615
38Interstitial pulmonary disease (HP:0006530)2.86358890
39Chronic otitis media (HP:0000389)2.86291361
40Agnosia (HP:0010524)2.85961535
41Hematochezia (HP:0002573)2.73955250
42Recurrent fungal infections (HP:0002841)2.73212216
43Optic neuritis (HP:0100653)2.70591058
44Retrobulbar optic neuritis (HP:0100654)2.70591058
45Esophageal neoplasm (HP:0100751)2.70580276
46Neoplasm of head and neck (HP:0012288)2.70580276
47Cellulitis (HP:0100658)2.68528483
48Periodontitis (HP:0000704)2.65289655
49Cerebral inclusion bodies (HP:0100314)2.64114937
50Nausea (HP:0002018)2.58507541
51Urticaria (HP:0001025)2.57885037
52Pulmonary infiltrates (HP:0002113)2.57326148
53Nuclear cataract (HP:0100018)2.57121325
54Mucopolysacchariduria (HP:0008155)2.56699014
55Urinary glycosaminoglycan excretion (HP:0003541)2.56699014
56Hypergammaglobulinemia (HP:0010702)2.56657964
57Protrusio acetabuli (HP:0003179)2.55343656
58Recurrent viral infections (HP:0004429)2.54086069
59Porencephaly (HP:0002132)2.53578593
60Pustule (HP:0200039)2.44125000
61Vertebral compression fractures (HP:0002953)2.41249487
62Loss of speech (HP:0002371)2.39632796
63Hepatosplenomegaly (HP:0001433)2.39584395
64Thin bony cortex (HP:0002753)2.39089680
65Abnormality of liposaccharide metabolism (HP:0010968)2.36904275
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.36904275
67Abnormality of glycolipid metabolism (HP:0010969)2.36904275
68Joint stiffness (HP:0001387)2.35936906
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35310401
70Abnormality of polysaccharide metabolism (HP:0011012)2.35310401
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35310401
72Aortic aneurysm (HP:0004942)2.35155763
73Cervical subluxation (HP:0003308)2.34142972
74Abnormality of complement system (HP:0005339)2.32416317
75Progressive visual loss (HP:0000529)2.31516759
76Pathologic fracture (HP:0002756)2.29304185
77J-shaped sella turcica (HP:0002680)2.24961529
78Complement deficiency (HP:0004431)2.23624743
79Bone pain (HP:0002653)2.23403266
80Peritonitis (HP:0002586)2.23175529
81Osteomyelitis (HP:0002754)2.22963477
82Steatorrhea (HP:0002570)2.22935142
83Protuberant abdomen (HP:0001538)2.18722427
84Increased CSF protein (HP:0002922)2.17454911
85Asymmetric septal hypertrophy (HP:0001670)2.16626184
86Abnormality of the nasal mucosa (HP:0000433)2.16167258
87Nasal polyposis (HP:0100582)2.13713140
88Premature loss of primary teeth (HP:0006323)2.12965998
89Abnormality of the pericardium (HP:0001697)2.11266367
90Abnormality of the periventricular white matter (HP:0002518)2.11004918
91Poor head control (HP:0002421)2.09202924
92Apathy (HP:0000741)2.07710474
93Purpura (HP:0000979)2.04088236
94Distal lower limb muscle weakness (HP:0009053)2.00826949
95Abnormality of the costochondral junction (HP:0000919)2.00777906
96Parakeratosis (HP:0001036)2.00772987
97Diminished motivation (HP:0000745)1.99357945
98Recurrent pneumonia (HP:0006532)1.99129811
99Peripheral demyelination (HP:0011096)1.98404335
100Malnutrition (HP:0004395)1.96387996
101Amyloidosis (HP:0011034)1.96334629
102Neuronal loss in central nervous system (HP:0002529)1.94863042
103Cerebral aneurysm (HP:0004944)1.94628900
104Xanthomatosis (HP:0000991)1.94115697
105Bilateral sensorineural hearing impairment (HP:0008619)1.93972187
106Upper motor neuron abnormality (HP:0002127)1.93781833
107Neurofibrillary tangles (HP:0002185)1.93345871
108Ovoid vertebral bodies (HP:0003300)1.93212749
109Inappropriate behavior (HP:0000719)1.90806727
110Progressive neurologic deterioration (HP:0002344)1.90390170
111Global brain atrophy (HP:0002283)1.89561273
112Autoimmune hemolytic anemia (HP:0001890)1.89347438
113Leukocytosis (HP:0001974)1.88312723
114Petechiae (HP:0000967)1.87414524
115Emphysema (HP:0002097)1.86782362
116Arterial thrombosis (HP:0004420)1.86636272
117Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83327355
118Increased serum ferritin (HP:0003281)1.82099081
119Bone cyst (HP:0012062)1.79837688
120Premature rupture of membranes (HP:0001788)1.79079418
121Skin ulcer (HP:0200042)1.78998657
122Supranuclear gaze palsy (HP:0000605)1.78654274
123Vascular tortuosity (HP:0004948)1.78650208
124Recurrent lower respiratory tract infections (HP:0002783)1.78205208
125Chronic mucocutaneous candidiasis (HP:0002728)1.76917095
126Recurrent cutaneous fungal infections (HP:0011370)1.76917095
127Dilatation of the ascending aorta (HP:0005111)1.75983129
128Hemoptysis (HP:0002105)1.74621769
129T lymphocytopenia (HP:0005403)1.73274718
130Aortic dissection (HP:0002647)1.72902752
131Arthralgia (HP:0002829)1.72215883
132Abnormality of T cell number (HP:0011839)1.72169113
133Joint hemorrhage (HP:0005261)1.72119358
134Pulmonary hypertension (HP:0002092)1.70379527
135Metaphyseal irregularity (HP:0003025)1.67308778
136Prolonged neonatal jaundice (HP:0006579)1.66820376
137Recurrent bronchitis (HP:0002837)1.65365034
138Dementia (HP:0000726)1.62693501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.00112493
2MAP3K143.85659765
3RIPK43.74621254
4ERN13.64790519
5TYK23.61605713
6BLK3.10177234
7IKBKE3.00372387
8IRAK42.87223786
9PIM22.72951536
10MAP4K12.50198418
11IRAK32.37376281
12IKBKB2.30906243
13JAK12.28040884
14KIT2.18234923
15JAK32.01731336
16PBK1.98462082
17TXK1.83787758
18CSK1.77816535
19FGR1.77527334
20LIMK11.77252452
21MATK1.76596494
22TGFBR21.67660951
23RPS6KA41.67148681
24STK161.57455978
25MAPK71.55856626
26FES1.52454897
27CDC42BPA1.51689804
28PDK21.45924011
29MAP3K31.41647580
30CHUK1.41449601
31ABL21.34529895
32MAP3K51.32864527
33EPHB11.31435634
34MAP3K101.31381376
35BMX1.29591512
36GRK51.20987091
37TAOK21.20563007
38HCK1.18861946
39MAP3K131.15856351
40MAPK151.10874075
41RIPK11.10735213
42BMPR1B1.07343252
43SYK1.05388105
44NEK91.04803764
45IRAK11.04368140
46BMPR21.03766544
47SCYL21.01057807
48IRAK20.99530841
49ZAP700.99526453
50NEK60.99235286
51FGFR40.97268006
52LYN0.96032823
53STK100.93096225
54CSF1R0.92963493
55ITK0.92528716
56MARK30.92029985
57DDR20.91904367
58JAK20.91677294
59LCK0.91586697
60MAP2K30.91343197
61EIF2AK20.86809241
62MYLK0.83041071
63LATS20.82726054
64DAPK30.82328537
65MAP2K20.81973120
66NME20.81651849
67MST1R0.81196570
68TTN0.80791266
69PIM10.80271719
70MST40.80211057
71PRPF4B0.79926634
72MAP3K110.76745208
73EGFR0.74923135
74PKN10.74028058
75MOS0.72451462
76EPHA30.72347776
77ARAF0.69317953
78RPS6KA20.68648123
79PRKCD0.66235452
80TEC0.65650149
81MAP3K60.65590448
82CAMK1D0.65090137
83PDPK10.64701790
84NLK0.64633402
85ABL10.63821947
86CDK60.63096066
87SIK20.62835642
88HIPK20.61367280
89LRRK20.60507236
90MAPKAPK30.58611073
91PLK20.58433802
92YES10.58106763
93SGK30.58077016
94MAPKAPK50.57200315
95GRK70.56459515
96PDK10.55948047
97ROCK20.55171142
98IGF1R0.55065489
99CAMK2G0.54168189
100FGFR30.52577783
101TGFBR10.52490950
102MAP3K10.52100516
103TRPM70.51118653
104TAOK30.51071358
105PAK60.49663341
106CAMKK20.48878510
107EPHB20.47468835
108ERBB30.46957964
109BTK0.46859348
110PDGFRA0.46279440
111ERBB40.45955609
112PDGFRB0.43721796
113MAPK40.43359250
114PIK3CG0.42308151
115MAPK120.42157831
116KSR20.41939423
117SGK20.41854086
118PRKG10.41379188
119MAPKAPK20.41187844
120DYRK1B0.40988689
121RPS6KA60.39978833
122DAPK20.39867845
123TESK10.38261615
124STK30.37677534
125DMPK0.37020967
126ADRBK20.36327592
127INSR0.35760577
128GSK3A0.35505853
129PAK40.32600100
130FYN0.31525732
131PRKG20.30225252
132PTK2B0.26217156
133RPS6KC10.25312046
134RPS6KL10.25312046
135PTK60.24498713
136MAP3K20.24475075

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.40279895
2Staphylococcus aureus infection_Homo sapiens_hsa051503.14594964
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.09109368
4Graft-versus-host disease_Homo sapiens_hsa053323.06362216
5Malaria_Homo sapiens_hsa051442.90799431
6Legionellosis_Homo sapiens_hsa051342.74541539
7Rheumatoid arthritis_Homo sapiens_hsa053232.62186684
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51388375
9Allograft rejection_Homo sapiens_hsa053302.46560801
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.40977531
11Pertussis_Homo sapiens_hsa051332.33661831
12Asthma_Homo sapiens_hsa053102.31200163
13Osteoclast differentiation_Homo sapiens_hsa043802.29186080
14TNF signaling pathway_Homo sapiens_hsa046682.26476332
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25160334
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25096618
17Tuberculosis_Homo sapiens_hsa051522.13324433
18African trypanosomiasis_Homo sapiens_hsa051432.04995970
19Influenza A_Homo sapiens_hsa051642.02033259
20Lysosome_Homo sapiens_hsa041421.93655128
21Measles_Homo sapiens_hsa051621.90572355
22Phagosome_Homo sapiens_hsa041451.90006503
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88974934
24Salmonella infection_Homo sapiens_hsa051321.80776313
25Type I diabetes mellitus_Homo sapiens_hsa049401.68054671
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.67915352
27Toxoplasmosis_Homo sapiens_hsa051451.62957050
28Herpes simplex infection_Homo sapiens_hsa051681.48106041
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47899135
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.38924052
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.37205185
32Chemokine signaling pathway_Homo sapiens_hsa040621.32943767
33B cell receptor signaling pathway_Homo sapiens_hsa046621.32870973
34Amoebiasis_Homo sapiens_hsa051461.31505474
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27182239
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24070719
37Antigen processing and presentation_Homo sapiens_hsa046121.23995513
38Shigellosis_Homo sapiens_hsa051311.21456221
39Hematopoietic cell lineage_Homo sapiens_hsa046401.21156867
40Hepatitis C_Homo sapiens_hsa051601.20688204
41Apoptosis_Homo sapiens_hsa042101.19511007
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15570559
43Hepatitis B_Homo sapiens_hsa051611.14609610
44Prion diseases_Homo sapiens_hsa050201.14037904
45Viral myocarditis_Homo sapiens_hsa054161.07534832
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.05581502
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96090436
48Other glycan degradation_Homo sapiens_hsa005110.90484708
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88700750
50Complement and coagulation cascades_Homo sapiens_hsa046100.83704372
51Autoimmune thyroid disease_Homo sapiens_hsa053200.81775272
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81714487
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.80682266
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.80292628
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75409040
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73258594
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68899537
58Renin secretion_Homo sapiens_hsa049240.67574380
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66500353
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62829337
61Galactose metabolism_Homo sapiens_hsa000520.62224355
62PPAR signaling pathway_Homo sapiens_hsa033200.62087163
63Type II diabetes mellitus_Homo sapiens_hsa049300.61922553
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60260309
65Proteoglycans in cancer_Homo sapiens_hsa052050.59478051
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58485261
67Collecting duct acid secretion_Homo sapiens_hsa049660.57734950
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56064997
69Sulfur metabolism_Homo sapiens_hsa009200.55474857
70* Primary bile acid biosynthesis_Homo sapiens_hsa001200.53507874
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.52501503
72T cell receptor signaling pathway_Homo sapiens_hsa046600.51995414
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51599909
74Prolactin signaling pathway_Homo sapiens_hsa049170.51059958
75Platelet activation_Homo sapiens_hsa046110.48451287
76Chronic myeloid leukemia_Homo sapiens_hsa052200.47820164
77HIF-1 signaling pathway_Homo sapiens_hsa040660.45572419
78Mineral absorption_Homo sapiens_hsa049780.44138280
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.40237834
80Ovarian steroidogenesis_Homo sapiens_hsa049130.38631677
81Histidine metabolism_Homo sapiens_hsa003400.37569206
82Arachidonic acid metabolism_Homo sapiens_hsa005900.37533287
83Acute myeloid leukemia_Homo sapiens_hsa052210.36585613
84Pancreatic cancer_Homo sapiens_hsa052120.36002232
85GnRH signaling pathway_Homo sapiens_hsa049120.35888351
86Small cell lung cancer_Homo sapiens_hsa052220.35807268
87Tryptophan metabolism_Homo sapiens_hsa003800.35466213
88Dorso-ventral axis formation_Homo sapiens_hsa043200.35382579
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34613568
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33311082
91HTLV-I infection_Homo sapiens_hsa051660.33240394
92Systemic lupus erythematosus_Homo sapiens_hsa053220.32842969
93ECM-receptor interaction_Homo sapiens_hsa045120.32556921
94Estrogen signaling pathway_Homo sapiens_hsa049150.32454114
95Focal adhesion_Homo sapiens_hsa045100.32295065
96Epstein-Barr virus infection_Homo sapiens_hsa051690.31337894
97Fructose and mannose metabolism_Homo sapiens_hsa000510.31142616
98VEGF signaling pathway_Homo sapiens_hsa043700.31065754
99Insulin resistance_Homo sapiens_hsa049310.31062759
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30828184
101Caffeine metabolism_Homo sapiens_hsa002320.30180114
102Gastric acid secretion_Homo sapiens_hsa049710.29347328
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28937803
104Salivary secretion_Homo sapiens_hsa049700.27087131
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26522374
106Bladder cancer_Homo sapiens_hsa052190.26094648
107Viral carcinogenesis_Homo sapiens_hsa052030.25434226
108Rap1 signaling pathway_Homo sapiens_hsa040150.25185608
109Synaptic vesicle cycle_Homo sapiens_hsa047210.24586567
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24164466
111Primary immunodeficiency_Homo sapiens_hsa053400.23870755
112Sphingolipid metabolism_Homo sapiens_hsa006000.23424172
113Adherens junction_Homo sapiens_hsa045200.23283458
114Endocytosis_Homo sapiens_hsa041440.22855305
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22802529
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22071116
117TGF-beta signaling pathway_Homo sapiens_hsa043500.20945246
118Vibrio cholerae infection_Homo sapiens_hsa051100.18924006
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18007550
120Renal cell carcinoma_Homo sapiens_hsa052110.17156806
121MAPK signaling pathway_Homo sapiens_hsa040100.15817582
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15087435
123Notch signaling pathway_Homo sapiens_hsa043300.13646391

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