CHAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cell aggregation (GO:0098743)9.56883015
2* cartilage condensation (GO:0001502)9.56883015
3positive regulation of extracellular matrix organization (GO:1903055)8.18624198
4notochord development (GO:0030903)7.85934804
5collagen fibril organization (GO:0030199)7.47220167
6limb bud formation (GO:0060174)7.41886492
7trivalent inorganic anion homeostasis (GO:0072506)7.25585857
8phosphate ion homeostasis (GO:0055062)7.25585857
9negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.93327634
10sphingomyelin metabolic process (GO:0006684)6.80855124
11replacement ossification (GO:0036075)6.56548993
12endochondral ossification (GO:0001958)6.56548993
13cartilage development (GO:0051216)6.47815613
14keratan sulfate biosynthetic process (GO:0018146)6.20203331
15positive regulation of chondrocyte differentiation (GO:0032332)5.94814476
16embryonic skeletal joint morphogenesis (GO:0060272)5.84370465
17regulation of extracellular matrix disassembly (GO:0010715)5.82558597
18proteoglycan metabolic process (GO:0006029)5.80263742
19chondroitin sulfate biosynthetic process (GO:0030206)5.71145860
20hypotonic response (GO:0006971)5.63661905
21negative regulation of bone mineralization (GO:0030502)5.61958118
22biomineral tissue development (GO:0031214)5.53709299
23chondrocyte differentiation (GO:0002062)5.45030463
24regulation of plasminogen activation (GO:0010755)5.39561173
25collagen catabolic process (GO:0030574)5.31761443
26nucleotide-sugar biosynthetic process (GO:0009226)5.21509448
27negative regulation of biomineral tissue development (GO:0070168)5.19666576
28positive regulation of cartilage development (GO:0061036)5.11645238
29collagen metabolic process (GO:0032963)5.09795323
30keratan sulfate metabolic process (GO:0042339)5.06151742
31skeletal system development (GO:0001501)5.01058680
32multicellular organismal catabolic process (GO:0044243)4.91750463
33regulation of extracellular matrix organization (GO:1903053)4.90098001
34multicellular organismal macromolecule metabolic process (GO:0044259)4.78118209
35iron ion import (GO:0097286)4.74196375
36epoxygenase P450 pathway (GO:0019373)4.73056529
37protein retention in ER lumen (GO:0006621)4.68919300
38multicellular organismal metabolic process (GO:0044236)4.58669564
39cellular glucuronidation (GO:0052695)4.55433552
40phosphate ion transmembrane transport (GO:0035435)4.52679406
41UDP-N-acetylglucosamine metabolic process (GO:0006047)4.50948825
42regulation of protein activation cascade (GO:2000257)4.49765738
43regulation of complement activation (GO:0030449)4.46624024
44exogenous drug catabolic process (GO:0042738)4.45495531
45cellular response to BMP stimulus (GO:0071773)4.41632524
46response to BMP (GO:0071772)4.41632524
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.39871288
48drug catabolic process (GO:0042737)4.36040932
49endothelial cell morphogenesis (GO:0001886)4.35941723
50lipopolysaccharide biosynthetic process (GO:0009103)4.33016174
51positive regulation of hormone biosynthetic process (GO:0046886)4.27995881
52ethanol oxidation (GO:0006069)4.25423959
53connective tissue development (GO:0061448)4.17105137
54complement activation, alternative pathway (GO:0006957)4.16559397
55regulation of chondrocyte differentiation (GO:0032330)4.13969958
56protein carboxylation (GO:0018214)4.12019154
57peptidyl-glutamic acid carboxylation (GO:0017187)4.12019154
58glycosaminoglycan biosynthetic process (GO:0006024)4.03359517
59glucuronate metabolic process (GO:0019585)4.01297868
60uronic acid metabolic process (GO:0006063)4.01297868
61chondrocyte proliferation (GO:0035988)4.01194025
62response to gravity (GO:0009629)4.00373786
63extracellular matrix disassembly (GO:0022617)3.98513414
64aminoglycan biosynthetic process (GO:0006023)3.97846879
65sulfur compound catabolic process (GO:0044273)3.97320386
66regulation of fibrinolysis (GO:0051917)3.96364791
67positive regulation of epidermal cell differentiation (GO:0045606)3.94633802
68regulation of cartilage development (GO:0061035)3.90032738
69ethanol metabolic process (GO:0006067)3.82247616
70response to magnesium ion (GO:0032026)3.80735766
71ossification (GO:0001503)3.80735005
72regulation of steroid hormone biosynthetic process (GO:0090030)3.77858996
73regulation of apoptotic cell clearance (GO:2000425)3.77108169
74glycoprotein metabolic process (GO:0009100)3.74536414
75peptidyl-proline hydroxylation (GO:0019511)3.74350762
76omega-hydroxylase P450 pathway (GO:0097267)3.71992121
77negative regulation of fibrinolysis (GO:0051918)3.70153539
78triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.70149508
79phosphate ion transport (GO:0006817)3.67401620
80myelin assembly (GO:0032288)3.64885461
81lipopolysaccharide metabolic process (GO:0008653)3.59580189
82regulation of triglyceride catabolic process (GO:0010896)3.59212566
83glycosaminoglycan catabolic process (GO:0006027)3.58025564
84thrombin receptor signaling pathway (GO:0070493)3.53570730
85complement activation, classical pathway (GO:0006958)3.51375850
86phospholipid efflux (GO:0033700)3.49832876
87negative regulation of ossification (GO:0030279)3.46903996
88urea metabolic process (GO:0019627)3.46312533
89regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.39569777
90decidualization (GO:0046697)3.39204652
91positive regulation of endothelial cell differentiation (GO:0045603)3.36249282
92aminoglycan catabolic process (GO:0006026)3.35681489
93endocardial cushion morphogenesis (GO:0003203)3.34029341
94regulation of bone mineralization (GO:0030500)3.33709301
95extracellular matrix organization (GO:0030198)3.29896730
96regulation of alkaline phosphatase activity (GO:0010692)3.29090848
97extracellular structure organization (GO:0043062)3.28687924
98L-phenylalanine catabolic process (GO:0006559)3.27676652
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27676652
100urea cycle (GO:0000050)3.27098289
101negative regulation of protein activation cascade (GO:2000258)3.26653121
102positive regulation of triglyceride lipase activity (GO:0061365)3.26387033
103positive regulation of lipoprotein lipase activity (GO:0051006)3.26387033
104hyperosmotic salinity response (GO:0042538)3.26195752
105negative regulation of cartilage development (GO:0061037)3.25022126
106positive regulation of p38MAPK cascade (GO:1900745)3.23681574
107nitrogen cycle metabolic process (GO:0071941)3.22293700
108complement activation (GO:0006956)3.22202278
109regulation of response to osmotic stress (GO:0047484)3.22012751
110negative regulation of humoral immune response (GO:0002921)3.21343272
111type B pancreatic cell development (GO:0003323)3.19058625
112short-term memory (GO:0007614)3.18876937
113positive regulation of hormone metabolic process (GO:0032352)3.18266593
114positive regulation of hemostasis (GO:1900048)3.17422889
115positive regulation of blood coagulation (GO:0030194)3.17422889
116drug metabolic process (GO:0017144)3.17366460
117negative regulation of smooth muscle cell differentiation (GO:0051151)3.17120108
118negative regulation of complement activation (GO:0045916)3.16855604
119negative regulation of sterol transport (GO:0032372)3.16640226
120negative regulation of cholesterol transport (GO:0032375)3.16640226
121COPII vesicle coating (GO:0048208)3.15632513
122protein activation cascade (GO:0072376)3.15479246
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15128706
124L-phenylalanine metabolic process (GO:0006558)3.15128706
125fibrinolysis (GO:0042730)3.14801547
126chondroitin sulfate metabolic process (GO:0030204)3.14422453
127endodermal cell differentiation (GO:0035987)3.12988988
128nucleotide-sugar metabolic process (GO:0009225)3.10573768
129proteoglycan biosynthetic process (GO:0030166)3.07984092
130negative regulation of gluconeogenesis (GO:0045721)3.06917462
131regulation of bone remodeling (GO:0046850)3.06861529
132mucopolysaccharide metabolic process (GO:1903510)3.06315612
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03796505
134negative regulation of chondrocyte differentiation (GO:0032331)3.00312924
135regulation of biomineral tissue development (GO:0070167)2.99350929
136protein hydroxylation (GO:0018126)2.98437966
137COPI coating of Golgi vesicle (GO:0048205)2.98107173
138Golgi transport vesicle coating (GO:0048200)2.98107173
139adhesion of symbiont to host cell (GO:0044650)2.97401204
140virion attachment to host cell (GO:0019062)2.97401204
141skin morphogenesis (GO:0043589)2.96768676
142negative regulation of blood coagulation (GO:0030195)2.95543392
143negative regulation of hemostasis (GO:1900047)2.95543392
144regulation of hormone biosynthetic process (GO:0046885)2.94327097
145mesenchyme morphogenesis (GO:0072132)2.93847362
146regulation of transforming growth factor beta2 production (GO:0032909)2.93493823
147positive regulation of coagulation (GO:0050820)2.93351473
148negative regulation of glycogen biosynthetic process (GO:0045719)2.92494516
149regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90853175
150regulation of humoral immune response (GO:0002920)2.90774214
151very-low-density lipoprotein particle assembly (GO:0034379)2.89241295
152embryonic viscerocranium morphogenesis (GO:0048703)2.89106354
153blood coagulation, intrinsic pathway (GO:0007597)2.87547277
154anion homeostasis (GO:0055081)2.86114766
155reverse cholesterol transport (GO:0043691)2.85785068
156hormone catabolic process (GO:0042447)2.82700028
157positive regulation of collagen biosynthetic process (GO:0032967)2.82574010
158plasma lipoprotein particle remodeling (GO:0034369)2.80985320
159protein-lipid complex remodeling (GO:0034368)2.80985320
160macromolecular complex remodeling (GO:0034367)2.80985320
161primary alcohol catabolic process (GO:0034310)2.80114540
162adhesion of symbiont to host (GO:0044406)2.79881487
163bone resorption (GO:0045453)2.79476681
164renal system process involved in regulation of blood volume (GO:0001977)2.78673998
165plasma lipoprotein particle assembly (GO:0034377)2.78123854
166negative regulation of glycogen metabolic process (GO:0070874)2.77997259
167regulation of cholesterol esterification (GO:0010872)2.77922295
168bone mineralization (GO:0030282)2.77539631
169negative regulation of wound healing (GO:0061045)2.77055397
170negative regulation of bone resorption (GO:0045779)2.76875649
171peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76179421
172cholesterol efflux (GO:0033344)2.75881661
173positive regulation of collagen metabolic process (GO:0010714)2.75841589
174protein-lipid complex assembly (GO:0065005)2.71107268
175glyoxylate metabolic process (GO:0046487)2.70137766
176renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.69847948
177negative regulation of coagulation (GO:0050819)2.67197536
178negative regulation of lipid transport (GO:0032369)2.64262948
179regulation of G0 to G1 transition (GO:0070316)2.63795018
180positive regulation of receptor internalization (GO:0002092)2.62400197
181positive regulation of lipid catabolic process (GO:0050996)2.61417324
182regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61290440
183regulation of collagen biosynthetic process (GO:0032965)2.59620223
184cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.6461402
185keratan sulfate catabolic process (GO:0042340)12.5998646
186response to parathyroid hormone (GO:0071107)11.1535129
187chondrocyte development (GO:0002063)10.0486803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.41433211
2GATA1_22025678_ChIP-Seq_K562_Human5.19823464
3AR_21572438_ChIP-Seq_LNCaP_Human4.58219470
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.83802575
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.83304758
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.82903043
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02898803
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.74053254
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.46402780
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.44673537
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40506272
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.28842262
13CJUN_26792858_Chip-Seq_BT549_Human2.26670829
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22445935
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17524225
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11211115
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.07510892
18CLOCK_20551151_ChIP-Seq_293T_Human2.07456164
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00113150
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96827936
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94934744
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91685029
23EGR1_19032775_ChIP-ChIP_M12_Human1.86278824
24* LXR_22292898_ChIP-Seq_THP-1_Human1.82809644
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77311322
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77202955
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75815261
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74081370
29JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66869540
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63179236
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62757188
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.59976371
33DROSHA_22980978_ChIP-Seq_HELA_Human1.59899905
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57236374
35VDR_24787735_ChIP-Seq_THP-1_Human1.54831402
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.53364755
37SOX2_20726797_ChIP-Seq_SW620_Human1.52053769
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50698158
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50535991
40RXR_22108803_ChIP-Seq_LS180_Human1.49557183
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48514260
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.47500194
43ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45033747
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.43961514
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43132282
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41625011
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41212474
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39903170
49BRD4_25478319_ChIP-Seq_HGPS_Human1.35460889
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.31074222
51TP53_18474530_ChIP-ChIP_U2OS_Human1.30760909
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29330748
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29330748
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27877986
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27717404
56RACK7_27058665_Chip-Seq_MCF-7_Human1.25664865
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22097654
58TCF7_22412390_ChIP-Seq_EML_Mouse1.21440996
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.20091913
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19040759
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.18643845
62GATA1_19941826_ChIP-Seq_K562_Human1.18419440
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18246296
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15585120
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15398740
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.15164335
67* SMC4_20622854_ChIP-Seq_HELA_Human1.14911406
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13808589
69SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13618841
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13530691
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13530691
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.12042324
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11621489
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10463726
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10282634
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10026030
77CTCF_21964334_Chip-Seq_Bcells_Human1.09555043
78SCL_19346495_ChIP-Seq_HPC-7_Human1.08713098
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08371311
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.08185489
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.08185489
82SA1_22415368_ChIP-Seq_MEFs_Mouse1.07706055
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05191466
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.04492690
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03490414
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.03145582
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02959911
88ELF5_23300383_ChIP-Seq_T47D_Human1.01714768
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.01688921
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01495714
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01413356
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.01061030
93* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99532634
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99353955
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.99192008
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98885955
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98602405
98RXR_22158963_ChIP-Seq_LIVER_Mouse0.98446995
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98309970
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97641726
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96884005
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96617412
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96404774
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.96217495
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95849655
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95820108
107RUNX_20019798_ChIP-Seq_JUKART_Human0.95495052
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95207944
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95150685
110MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94976795
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.94971633
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94971496
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.94607156
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94443812
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94313105
116HNF4A_19822575_ChIP-Seq_HepG2_Human0.93983080
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92961768
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92961768
119KDM2B_26808549_Chip-Seq_DND41_Human0.92731930
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92195517
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91894837
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91599489
123KDM2B_26808549_Chip-Seq_K562_Human0.90264786
124SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89785684
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89001341
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88819669
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88686530
128TP63_22573176_ChIP-Seq_HFKS_Human0.88663962
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.88380597
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87068642
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86977819
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86768189
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86421999
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.86300332
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85840921
136SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85832753
137SMRT_27268052_Chip-Seq_Bcells_Human0.85813210
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85621721
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85415638
140CTCF_27219007_Chip-Seq_Bcells_Human0.85388961
141KLF5_25053715_ChIP-Seq_YYC3_Human0.85355962
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84817895
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84432893
144ATF3_27146783_Chip-Seq_COLON_Human0.84325000
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83919224
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83895017
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83895017
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83784092
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83130576
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82404046
151AHR_22903824_ChIP-Seq_MCF-7_Human0.82169952
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82120865
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81758038
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81300703
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.81020162
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80744959
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80494742
158TP63_23658742_ChIP-Seq_EP156T_Human0.79786640
159SA1_27219007_Chip-Seq_ERYTHROID_Human0.79771576
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78560699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation5.90882291
2MP0004134_abnormal_chest_morphology5.90741223
3MP0005503_abnormal_tendon_morphology5.67442637
4MP0003646_muscle_fatigue4.85631546
5MP0002282_abnormal_trachea_morphology4.60784209
6MP0005083_abnormal_biliary_tract4.55823398
7MP0000163_abnormal_cartilage_morphology4.13273743
8MP0005365_abnormal_bile_salt4.08599917
9MP0009250_abnormal_appendicular_skeleto3.94681154
10MP0005085_abnormal_gallbladder_physiolo3.83628156
11MP0003283_abnormal_digestive_organ3.81636679
12MP0005360_urolithiasis3.80403590
13MP0002115_abnormal_skeleton_extremities3.35916152
14MP0009780_abnormal_chondrocyte_physiolo2.90722085
15MP0002113_abnormal_skeleton_development2.86889783
16MP0002089_abnormal_postnatal_growth/wei2.85328761
17MP0001666_abnormal_nutrient_absorption2.84673457
18MP0001542_abnormal_bone_strength2.83207184
19MP0002896_abnormal_bone_mineralization2.67832655
20MP0004019_abnormal_vitamin_homeostasis2.63269732
21MP0005508_abnormal_skeleton_morphology2.56268712
22MP0001533_abnormal_skeleton_physiology2.46381385
23MP0005390_skeleton_phenotype2.44726258
24MP0008875_abnormal_xenobiotic_pharmacok2.41574550
25MP0002909_abnormal_adrenal_gland2.34034319
26MP0001299_abnormal_eye_distance/2.22052680
27MP0000751_myopathy2.21595941
28MP0002109_abnormal_limb_morphology2.17161235
29MP0003183_abnormal_peptide_metabolism2.11745689
30MP0000762_abnormal_tongue_morphology2.11258213
31MP0003795_abnormal_bone_structure2.00129353
32MP0002108_abnormal_muscle_morphology1.92707627
33MP0001270_distended_abdomen1.86096936
34MP0008438_abnormal_cutaneous_collagen1.85925686
35MP0003123_paternal_imprinting1.82502166
36MP0005275_abnormal_skin_tensile1.78951614
37MP0009384_cardiac_valve_regurgitation1.76601240
38MP0005451_abnormal_body_composition1.72100828
39MP0003656_abnormal_erythrocyte_physiolo1.69807702
40MP0003868_abnormal_feces_composition1.65938340
41MP0000049_abnormal_middle_ear1.55939092
42MP0002116_abnormal_craniofacial_bone1.50836202
43MP0002998_abnormal_bone_remodeling1.45257049
44MP0010329_abnormal_lipoprotein_level1.35608252
45MP0005409_darkened_coat_color1.31987844
46MP0003436_decreased_susceptibility_to1.28997471
47MP0008004_abnormal_stomach_pH1.27886261
48MP0003755_abnormal_palate_morphology1.23482158
49MP0009840_abnormal_foam_cell1.23322828
50MP0000343_altered_response_to1.23024113
51MP0001765_abnormal_ion_homeostasis1.22275717
52MP0003279_aneurysm1.21915327
53MP0000432_abnormal_head_morphology1.20381510
54MP0002139_abnormal_hepatobiliary_system1.19841152
55MP0005381_digestive/alimentary_phenotyp1.19805755
56MP0003252_abnormal_bile_duct1.18974448
57MP0003191_abnormal_cellular_cholesterol1.18013948
58MP0000604_amyloidosis1.15628518
59MP0001663_abnormal_digestive_system1.14983754
60MP0001873_stomach_inflammation1.12076961
61MP0003195_calcinosis1.11143281
62MP0005058_abnormal_lysosome_morphology1.10494937
63MP0002249_abnormal_larynx_morphology1.10220009
64MP0002114_abnormal_axial_skeleton1.07477137
65MP0005023_abnormal_wound_healing1.06613709
66MP0002233_abnormal_nose_morphology1.06556118
67MP0004272_abnormal_basement_membrane1.06286852
68MP0002111_abnormal_tail_morphology1.04795618
69MP0003566_abnormal_cell_adhesion1.04111136
70MP0005636_abnormal_mineral_homeostasis1.03854618
71MP0003705_abnormal_hypodermis_morpholog1.00968482
72MP0000462_abnormal_digestive_system0.98092966
73MP0003787_abnormal_imprinting0.94814812
74MP0000465_gastrointestinal_hemorrhage0.94512464
75MP0002118_abnormal_lipid_homeostasis0.91281880
76MP0005395_other_phenotype0.91200264
77MP0002168_other_aberrant_phenotype0.91193289
78MP0000767_abnormal_smooth_muscle0.91001660
79MP0001958_emphysema0.90599739
80MP0002163_abnormal_gland_morphology0.88401133
81MP0005332_abnormal_amino_acid0.87959680
82MP0004883_abnormal_blood_vessel0.87009075
83MP0002932_abnormal_joint_morphology0.85750888
84MP0004197_abnormal_fetal_growth/weight/0.85726267
85MP0009115_abnormal_fat_cell0.85210363
86MP0003172_abnormal_lysosome_physiology0.84606346
87MP0003935_abnormal_craniofacial_develop0.84255929
88MP0005076_abnormal_cell_differentiation0.83615358
89MP0003879_abnormal_hair_cell0.81377431
90MP0005319_abnormal_enzyme/_coenzyme0.80728985
91MP0002138_abnormal_hepatobiliary_system0.80378059
92MP0002876_abnormal_thyroid_physiology0.79680950
93MP0005164_abnormal_response_to0.78137132
94MP0000609_abnormal_liver_physiology0.78008569
95MP0003091_abnormal_cell_migration0.77667000
96MP0002419_abnormal_innate_immunity0.77636776
97MP0002234_abnormal_pharynx_morphology0.76727182
98MP0002971_abnormal_brown_adipose0.75799303
99MP0005257_abnormal_intraocular_pressure0.72953033
100MP0004084_abnormal_cardiac_muscle0.71430418
101MP0001849_ear_inflammation0.70894098
102MP0003718_maternal_effect0.70183416
103MP0001243_abnormal_dermal_layer0.69517389
104MP0004264_abnormal_extraembryonic_tissu0.69067501
105MP0003937_abnormal_limbs/digits/tail_de0.68993722
106MP0004484_altered_response_of0.68966164
107MP0006054_spinal_hemorrhage0.68859197
108MP0010155_abnormal_intestine_physiology0.67001386
109MP0009643_abnormal_urine_homeostasis0.66781147
110MP0001963_abnormal_hearing_physiology0.66124149
111MP0005670_abnormal_white_adipose0.65347961
112MP0001790_abnormal_immune_system0.65028698
113MP0005387_immune_system_phenotype0.65028698
114MP0000249_abnormal_blood_vessel0.63746988
115MP0001879_abnormal_lymphatic_vessel0.63555526
116MP0002132_abnormal_respiratory_system0.61833228
117MP0004147_increased_porphyrin_level0.59861037
118MP0000003_abnormal_adipose_tissue0.59623326
119MP0005084_abnormal_gallbladder_morpholo0.56618315
120MP0000685_abnormal_immune_system0.56057834
121MP0004185_abnormal_adipocyte_glucose0.55901125
122MP0010234_abnormal_vibrissa_follicle0.55116577
123MP0009697_abnormal_copulation0.55048182
124MP0005375_adipose_tissue_phenotype0.54292934
125MP0003329_amyloid_beta_deposits0.53826887
126MP0005535_abnormal_body_temperature0.52287633
127MP0002136_abnormal_kidney_physiology0.51591370
128MP0005369_muscle_phenotype0.51330268
129MP0003122_maternal_imprinting0.51134871
130MP0001943_abnormal_respiration0.48750354
131MP0005666_abnormal_adipose_tissue0.48425047
132MP0004036_abnormal_muscle_relaxation0.47195077
133MP0003121_genomic_imprinting0.45042742
134MP0000749_muscle_degeneration0.44313347
135MP0002060_abnormal_skin_morphology0.43423257
136MP0010368_abnormal_lymphatic_system0.41497118
137MP0001851_eye_inflammation0.40761539
138MP0003942_abnormal_urinary_system0.40161374
139MP0003806_abnormal_nucleotide_metabolis0.40039552
140MP0005166_decreased_susceptibility_to0.38659603
141MP0003075_altered_response_to0.37953282
142MP0001286_abnormal_eye_development0.36088635
143MP0003385_abnormal_body_wall0.35306854
144MP0002128_abnormal_blood_circulation0.35018937
145MP0010030_abnormal_orbit_morphology0.33853602
146MP0001175_abnormal_lung_morphology0.33753765
147MP0003119_abnormal_digestive_system0.32397642
148MP0000566_synostosis0.32066679
149MP0000428_abnormal_craniofacial_morphol0.29540371
150MP0001664_abnormal_digestion0.29444593
151MP0002106_abnormal_muscle_physiology0.27969220
152MP0003448_altered_tumor_morphology0.27251466
153MP0008775_abnormal_heart_ventricle0.26770941

Predicted human phenotypes

RankGene SetZ-score
1Hypophosphatemic rickets (HP:0004912)9.82480135
2Epiphyseal dysplasia (HP:0002656)9.54348821
3Irregular epiphyses (HP:0010582)9.04576774
4Vitreoretinal degeneration (HP:0000655)7.21209914
5Increased density of long bones (HP:0006392)7.18152059
6Small epiphyses (HP:0010585)6.70528231
7Hypoplastic ischia (HP:0003175)6.33924918
8Abnormal tarsal ossification (HP:0008369)6.21508166
9Abnormality of calcium-phosphate metabolism (HP:0100530)6.07004302
10Cupped ribs (HP:0000887)5.92137308
11Delayed epiphyseal ossification (HP:0002663)5.70570157
12Metaphyseal cupping (HP:0003021)5.65740064
13Flat capital femoral epiphysis (HP:0003370)5.62916821
14Abnormality of the ischium (HP:0003174)5.59786572
15Genu varum (HP:0002970)5.46738664
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.43072623
17Facial diplegia (HP:0001349)5.40159011
18Flat acetabular roof (HP:0003180)5.15814696
19Broad ribs (HP:0000885)5.12268641
20Rickets (HP:0002748)5.07000907
21Overgrowth (HP:0001548)4.81858401
22Metaphyseal dysplasia (HP:0100255)4.69945845
23Abnormality of femoral epiphyses (HP:0006499)4.69260339
24Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.69260339
25Osteomalacia (HP:0002749)4.65436017
26Mild short stature (HP:0003502)4.63712084
27Abnormal foot bone ossification (HP:0010675)4.58588648
28Abnormality of the vertebral endplates (HP:0005106)4.51358524
29Craniofacial hyperostosis (HP:0004493)4.50118724
30Tibial bowing (HP:0002982)4.44700210
31Abnormality of the epiphysis of the femoral head (HP:0010574)4.33546587
32Irregular vertebral endplates (HP:0003301)4.17868328
33Femoral bowing (HP:0002980)4.15914704
34Neonatal short-limb short stature (HP:0008921)4.15065036
35Short femoral neck (HP:0100864)4.07432466
36Hypophosphatemia (HP:0002148)4.06982614
37Arthropathy (HP:0003040)4.04721900
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.04558705
39Absent epiphyses (HP:0010577)4.04558705
40Flattened epiphyses (HP:0003071)4.02890672
41Abnormality of the femoral head (HP:0003368)3.99722490
42Sudden death (HP:0001699)3.96669792
43Cranial hyperostosis (HP:0004437)3.93822600
44Choanal stenosis (HP:0000452)3.87418586
45Osteoarthritis (HP:0002758)3.86578204
46Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.73430068
47Metaphyseal irregularity (HP:0003025)3.60843743
48Abnormal vertebral ossification (HP:0100569)3.40129767
49Beaking of vertebral bodies (HP:0004568)3.38933383
50Coxa vara (HP:0002812)3.38711824
51Enlarged epiphyses (HP:0010580)3.37660251
52Elevated alkaline phosphatase (HP:0003155)3.34990500
53Abnormality of carpal bone ossification (HP:0006257)3.31548662
54Abnormality of the proximal phalanges of the hand (HP:0009834)3.22655096
55Deep venous thrombosis (HP:0002625)3.20757776
56Platyspondyly (HP:0000926)3.16543858
57Abnormality of the phalanges of the 2nd finger (HP:0009541)3.15622135
58Waddling gait (HP:0002515)3.13165992
59Abnormality of the pubic bones (HP:0003172)3.12584071
60Protuberant abdomen (HP:0001538)3.11750378
61Complement deficiency (HP:0004431)3.10225608
62Abnormality of alkaline phosphatase activity (HP:0004379)3.07370490
63Carpal bone hypoplasia (HP:0001498)3.05707036
64Abnormal enzyme/coenzyme activity (HP:0012379)3.02571175
65Barrel-shaped chest (HP:0001552)3.00561601
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99359758
67Cervical subluxation (HP:0003308)2.94626661
68Ovoid vertebral bodies (HP:0003300)2.91117300
69Aplasia/hypoplasia of the femur (HP:0005613)2.91007307
70Limited hip movement (HP:0008800)2.86202249
71Limited elbow extension (HP:0001377)2.82436285
72Spondylolisthesis (HP:0003302)2.82183146
73Vertebral clefting (HP:0008428)2.80588307
74Persistence of primary teeth (HP:0006335)2.79423099
75Systemic lupus erythematosus (HP:0002725)2.75719187
76Thoracolumbar scoliosis (HP:0002944)2.72751608
77Abnormality of Sharpey fibers (HP:0100685)2.71879064
78Lumbar hyperlordosis (HP:0002938)2.65082322
79Abnormal hand bone ossification (HP:0010660)2.64279234
80Spinal cord compression (HP:0002176)2.64266939
81Hip contracture (HP:0003273)2.62734834
82Stillbirth (HP:0003826)2.59309304
83Abnormal ossification of hand bones (HP:0005921)2.55659419
84Hypoplasia of the odontoid process (HP:0003311)2.55321799
85Exostoses (HP:0100777)2.53074827
86Abnormality of complement system (HP:0005339)2.51287750
87Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.51210437
88Absent frontal sinuses (HP:0002688)2.42669633
89Vascular calcification (HP:0004934)2.35992260
90Short middle phalanx of finger (HP:0005819)2.35170406
91Abnormality of the lumbar spine (HP:0100712)2.34207153
92Disproportionate short-trunk short stature (HP:0003521)2.32007151
93Abnormality of the 2nd finger (HP:0004100)2.31390325
94Thin ribs (HP:0000883)2.29244655
95Cardiovascular calcification (HP:0011915)2.28724108
96Glossoptosis (HP:0000162)2.26272636
97Abnormality of the vitreous humor (HP:0004327)2.26122083
98Mesomelia (HP:0003027)2.23751307
99Abnormality of incisor morphology (HP:0011063)2.20674959
100Glomerulonephritis (HP:0000099)2.18171273
101Long clavicles (HP:0000890)2.15933513
102Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.15608028
103Prolonged partial thromboplastin time (HP:0003645)2.15193745
104Abnormality of the acetabulum (HP:0003170)2.15035925
105Micromelia (HP:0002983)2.12717603
106Abnormality of the odontoid process (HP:0003310)2.08954189
107Joint hemorrhage (HP:0005261)2.06023257
108Hypoplastic ilia (HP:0000946)2.05996598
109Broad phalanx (HP:0006009)2.05759658
110Hypoplastic pelvis (HP:0008839)2.05338318
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03674398
112Constricted visual fields (HP:0001133)2.02505459
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01501340
114Relative macrocephaly (HP:0004482)2.01221621
115Papilledema (HP:0001085)13.8623150
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)11.0867035
117Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98957201
118Fibular hypoplasia (HP:0003038)1.98943825
119Flared metaphyses (HP:0003015)1.97697766
120Abnormal cortical bone morphology (HP:0003103)1.96500703
121Vertebral hypoplasia (HP:0008417)1.95882077
122Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.95882077
123Progressive visual loss (HP:0000529)1.94567736
124Spinal canal stenosis (HP:0003416)1.94341476
125Broad long bones (HP:0005622)1.93971221
126Arterial tortuosity (HP:0005116)1.93237458
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93063233
128Abnormality of the phalanges of the 5th finger (HP:0004213)1.92324958
129Ulnar deviation of the wrist (HP:0003049)1.92224825
130Bone pain (HP:0002653)1.90731452
131Abnormality of the middle phalanges of the toes (HP:0010183)1.88070538
132Short ribs (HP:0000773)1.84984467
133Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.84130566
134Radial bowing (HP:0002986)1.84128231
135Mixed hearing impairment (HP:0000410)1.82318984
136Vascular tortuosity (HP:0004948)1.82144734
137Joint stiffness (HP:0001387)1.81774842
138Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.80672662
139Wormian bones (HP:0002645)1.79826967
140Flared iliac wings (HP:0002869)1.79075610
141Abnormality of the middle phalanges of the hand (HP:0009833)1.76963078
142Genu valgum (HP:0002857)1.74591514
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74023353
144Mitral stenosis (HP:0001718)1.72596064
145Hypobetalipoproteinemia (HP:0003563)1.71344849
146Abnormal cartilage morphology (HP:0002763)1.67164478
147Hydroxyprolinuria (HP:0003080)1.66605723
148Abnormality of proline metabolism (HP:0010907)1.66605723
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66438688
150Chondrocalcinosis (HP:0000934)1.59432626
151Abnormality of the frontal sinuses (HP:0002687)1.57540927
152Abnormal urine phosphate concentration (HP:0012599)1.56126040
153Xanthomatosis (HP:0000991)1.55846644
154Recurrent gram-negative bacterial infections (HP:0005420)1.50676479
155Protrusio acetabuli (HP:0003179)1.50306666
156Exercise-induced myalgia (HP:0003738)1.48923260
157Hemorrhage of the eye (HP:0011885)1.48361082
158Mucopolysacchariduria (HP:0008155)1.47487505
159Urinary glycosaminoglycan excretion (HP:0003541)1.47487505
160Nephritis (HP:0000123)1.46364847
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.44473576
162Osteolytic defects of the hand bones (HP:0009699)1.44473576
163Obstructive sleep apnea (HP:0002870)1.43782640
164J-shaped sella turcica (HP:0002680)1.42148295
165Aortic dissection (HP:0002647)1.41506694
166Increased intracranial pressure (HP:0002516)1.40024731
167Abnormality of intracranial pressure (HP:0012640)1.40024731
168Hyperlipoproteinemia (HP:0010980)1.39708705
169Hypercalcemia (HP:0003072)1.37908149
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.35858074
171Abnormality of polysaccharide metabolism (HP:0011012)1.35858074
172Abnormality of glycosaminoglycan metabolism (HP:0004371)1.35858074
173Aortic aneurysm (HP:0004942)1.35050775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.07302331
2MAP3K36.66760633
3STK245.03642333
4STK38L4.61213125
5PRKG24.60744353
6NME13.47625302
7RIPK13.45013573
8PRPF4B2.07811345
9FGFR42.07534777
10ERBB32.00693720
11SIK11.98568507
12MAP3K131.97815244
13MST41.72457692
14PDGFRA1.70968966
15PIM21.70608809
16MAPK151.68721129
17TAOK11.64486573
18MAP2K31.64003903
19TRPM71.58538269
20STK31.48177409
21MAP3K71.41979964
22MARK21.37644195
23LATS11.36848524
24ICK1.34940776
25RIPK41.34389909
26EEF2K1.32540533
27TYK21.30966369
28PDPK11.30381373
29NUAK11.29755745
30MAP3K21.23711951
31MKNK21.09570371
32KSR21.08949299
33TRIB31.08787328
34DYRK1A1.04792653
35CDC42BPA1.04017088
36MAPK121.03292761
37MAP3K11.01337473
38PRKAA21.00935071
39EIF2AK31.00134806
40SMG10.99729275
41SGK30.99385169
42DYRK1B0.99126889
43PHKG10.95279658
44CAMKK20.95245875
45WNK40.95146607
46TGFBR10.93843930
47PLK20.91564030
48NTRK20.90711286
49TGFBR20.90216715
50MAPKAPK30.89810631
51PDK10.89637837
52PIK3CA0.89551322
53ZAP700.88122948
54TIE10.87948954
55MAP3K100.87254635
56NME20.87068108
57MAP3K60.86657198
58TNK20.85426167
59SGK20.83498859
60CDK120.81131157
61GSK3A0.80131935
62MAPK70.79630641
63CSF1R0.78675685
64NLK0.76872072
65MET0.74574967
66TEC0.74428396
67GRK60.73926426
68MAPK40.73383215
69EIF2AK10.72599303
70NEK90.72486686
71TESK10.72334346
72HIPK20.70637419
73JAK10.70113529
74EPHA20.69979594
75RPS6KA20.69889343
76ARAF0.69339804
77SGK4940.68644982
78SGK2230.68644982
79FGFR30.67750881
80ERBB20.65914539
81ROCK10.65008522
82EPHB10.64205693
83MAP3K90.63529681
84MKNK10.63481387
85MAP2K60.63237776
86TAOK30.63030913
87TBK10.62532868
88PTK2B0.62295558
89MAPK110.61223748
90STK380.60383663
91PTK60.59284761
92PDK20.59010224
93NEK60.58828678
94IKBKB0.56999091
95MTOR0.55393537
96TAOK20.54329363
97MAP3K110.53755914
98PRKAA10.52746235
99CSK0.52705172
100TXK0.52311913
101PRKD20.51718802
102BLK0.51142687
103BMPR1B0.50189668
104MAP2K40.49435258
105PIM10.49292548
106PBK0.48488201
107SIK20.48345270
108CAMK1G0.47450445
109PDGFRB0.47135794
110MUSK0.46695399
111LRRK20.43941095
112PRKG10.42027182
113MAP2K10.41213367
114NTRK30.40181418
115MELK0.38942703
116FGFR10.38630224
117CHUK0.36633644
118EIF2AK20.36592624
119CDK80.36074286
120MAP4K10.33922727
121ERN10.32932933
122STK390.32114884
123IGF1R0.31292774
124OBSCN0.30906434
125MAPK30.29450388
126BMX0.27498058
127TTN0.26546085
128EPHA30.26358977
129PRKACG0.25669711
130PRKCD0.25399370
131PINK10.24376475
132CAMKK10.23629687
133ABL10.23474777
134MAPK100.23114437
135MAP3K140.22686514
136RPS6KA40.21987750
137SIK30.21753425
138RPS6KB10.21431616
139MAPK10.20676660
140DAPK20.18886216
141WNK10.18391335
142CDK90.18286326
143PIK3CG0.16925334
144INSR0.16350261
145MST1R0.16253384
146CSNK1A1L0.16081137
147PKN20.14911142
148MAP3K50.14143361
149BTK0.13492249
150SGK10.13267026
151ERBB40.12774266
152RET0.12662904
153PTK20.12595069
154KSR10.12395921
155ILK0.12028080
156PHKG20.11629540

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.52399311
2Protein digestion and absorption_Homo sapiens_hsa049746.19803040
3* ECM-receptor interaction_Homo sapiens_hsa045125.97426007
4Phenylalanine metabolism_Homo sapiens_hsa003602.97854322
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92747358
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.59325457
7Histidine metabolism_Homo sapiens_hsa003402.50907212
8Sphingolipid metabolism_Homo sapiens_hsa006002.48456735
9Malaria_Homo sapiens_hsa051442.46439961
10Caffeine metabolism_Homo sapiens_hsa002322.43427297
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42301261
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.40015267
13* Focal adhesion_Homo sapiens_hsa045102.30331515
14Steroid biosynthesis_Homo sapiens_hsa001002.13759289
15Tyrosine metabolism_Homo sapiens_hsa003502.11526180
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.98697956
17Starch and sucrose metabolism_Homo sapiens_hsa005001.95392019
18Sulfur metabolism_Homo sapiens_hsa009201.84500761
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82872669
20Fatty acid degradation_Homo sapiens_hsa000711.81455048
21Olfactory transduction_Homo sapiens_hsa047401.76412604
22TGF-beta signaling pathway_Homo sapiens_hsa043501.76222340
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65635630
24* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64938319
25Staphylococcus aureus infection_Homo sapiens_hsa051501.59304331
26Protein export_Homo sapiens_hsa030601.57072721
27Folate biosynthesis_Homo sapiens_hsa007901.54278409
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49384359
29PPAR signaling pathway_Homo sapiens_hsa033201.48180045
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.43881282
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36451640
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34059146
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.31329609
34Other glycan degradation_Homo sapiens_hsa005111.30806282
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27977933
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.20186483
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17246300
38Linoleic acid metabolism_Homo sapiens_hsa005911.15535604
39Prion diseases_Homo sapiens_hsa050201.14748264
40Ovarian steroidogenesis_Homo sapiens_hsa049131.14516531
41Fat digestion and absorption_Homo sapiens_hsa049751.05762755
42Arginine and proline metabolism_Homo sapiens_hsa003301.03833251
43Selenocompound metabolism_Homo sapiens_hsa004501.03093325
44beta-Alanine metabolism_Homo sapiens_hsa004100.94925522
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93631593
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93555793
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92973900
48Proteoglycans in cancer_Homo sapiens_hsa052050.92127568
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90792554
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89755649
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88438110
52Circadian rhythm_Homo sapiens_hsa047100.87508076
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86758114
54Hippo signaling pathway_Homo sapiens_hsa043900.85798000
55ABC transporters_Homo sapiens_hsa020100.85167367
56Renin-angiotensin system_Homo sapiens_hsa046140.83017378
57Galactose metabolism_Homo sapiens_hsa000520.80095306
58Fructose and mannose metabolism_Homo sapiens_hsa000510.77747755
59Hedgehog signaling pathway_Homo sapiens_hsa043400.76248113
60Complement and coagulation cascades_Homo sapiens_hsa046100.75821317
61Osteoclast differentiation_Homo sapiens_hsa043800.75737257
62Lysine degradation_Homo sapiens_hsa003100.74513045
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73016325
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70580506
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70394976
66Tryptophan metabolism_Homo sapiens_hsa003800.69655775
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68833404
68N-Glycan biosynthesis_Homo sapiens_hsa005100.67692604
69Platelet activation_Homo sapiens_hsa046110.65007064
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62842366
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62330118
72Vitamin digestion and absorption_Homo sapiens_hsa049770.61950191
73Insulin signaling pathway_Homo sapiens_hsa049100.61722159
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61692747
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61567824
76Basal cell carcinoma_Homo sapiens_hsa052170.59375743
77Chronic myeloid leukemia_Homo sapiens_hsa052200.58557768
78Mineral absorption_Homo sapiens_hsa049780.58319436
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58294664
80Phagosome_Homo sapiens_hsa041450.58215473
81Long-term depression_Homo sapiens_hsa047300.57693736
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56399449
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55323888
84B cell receptor signaling pathway_Homo sapiens_hsa046620.55157792
85Hepatitis B_Homo sapiens_hsa051610.53502660
86Insulin resistance_Homo sapiens_hsa049310.49944061
87Lysosome_Homo sapiens_hsa041420.49526692
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.48654195
89Hematopoietic cell lineage_Homo sapiens_hsa046400.47476838
90Pertussis_Homo sapiens_hsa051330.47338866
91Thyroid hormone synthesis_Homo sapiens_hsa049180.46835157
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46226912
93Collecting duct acid secretion_Homo sapiens_hsa049660.45429542
94AMPK signaling pathway_Homo sapiens_hsa041520.45218386
95Salivary secretion_Homo sapiens_hsa049700.44957068
96Bladder cancer_Homo sapiens_hsa052190.44817783
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.44774498
98Choline metabolism in cancer_Homo sapiens_hsa052310.44349152
99Pancreatic secretion_Homo sapiens_hsa049720.42812702
100Arachidonic acid metabolism_Homo sapiens_hsa005900.42634925
101Dilated cardiomyopathy_Homo sapiens_hsa054140.42448292
102Peroxisome_Homo sapiens_hsa041460.42296953
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41715024
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41383057
105Butanoate metabolism_Homo sapiens_hsa006500.41292009
106Biosynthesis of amino acids_Homo sapiens_hsa012300.40472219
107Glycerolipid metabolism_Homo sapiens_hsa005610.39278310
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.37519834
109Estrogen signaling pathway_Homo sapiens_hsa049150.36895496
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.36232921
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34926096
112Notch signaling pathway_Homo sapiens_hsa043300.34554984
113Gap junction_Homo sapiens_hsa045400.34397160
114HIF-1 signaling pathway_Homo sapiens_hsa040660.33157786
115Prolactin signaling pathway_Homo sapiens_hsa049170.33021502
116GnRH signaling pathway_Homo sapiens_hsa049120.31262436
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30789797
118TNF signaling pathway_Homo sapiens_hsa046680.30499917
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30235101
120Wnt signaling pathway_Homo sapiens_hsa043100.29510150
121Oxytocin signaling pathway_Homo sapiens_hsa049210.29384834
122T cell receptor signaling pathway_Homo sapiens_hsa046600.28913301
123Legionellosis_Homo sapiens_hsa051340.28285928
124HTLV-I infection_Homo sapiens_hsa051660.28252509
125Glioma_Homo sapiens_hsa052140.28245519
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27571000
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27481913
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.26337225
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25985809
130Long-term potentiation_Homo sapiens_hsa047200.25409019
131Acute myeloid leukemia_Homo sapiens_hsa052210.25308553
132Non-small cell lung cancer_Homo sapiens_hsa052230.25042619
133Bile secretion_Homo sapiens_hsa049760.25021823
134Arginine biosynthesis_Homo sapiens_hsa002200.24983873
135Circadian entrainment_Homo sapiens_hsa047130.24806271
136Renin secretion_Homo sapiens_hsa049240.23987613
137Melanogenesis_Homo sapiens_hsa049160.21225243
138Adherens junction_Homo sapiens_hsa045200.19697924
139Amoebiasis_Homo sapiens_hsa051460.19609886
140Vibrio cholerae infection_Homo sapiens_hsa051100.19093860
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.18966743
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.18258914
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17800043
144Glucagon signaling pathway_Homo sapiens_hsa049220.17322245
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.17056731
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.16742432
147Cocaine addiction_Homo sapiens_hsa050300.16738579
148Retinol metabolism_Homo sapiens_hsa008300.16034711
149Prostate cancer_Homo sapiens_hsa052150.15947598
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15649631
151Apoptosis_Homo sapiens_hsa042100.14648683
152cAMP signaling pathway_Homo sapiens_hsa040240.11377055
153VEGF signaling pathway_Homo sapiens_hsa043700.11361385
154Chemical carcinogenesis_Homo sapiens_hsa052040.11191075
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10328841
156Thyroid cancer_Homo sapiens_hsa052160.10327395
157Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10057446
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.09681638
159Pathways in cancer_Homo sapiens_hsa052000.07791000

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