CHADL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.65866403
2axon ensheathment in central nervous system (GO:0032291)6.65866403
3axon ensheathment (GO:0008366)4.90365681
4ensheathment of neurons (GO:0007272)4.90365681
5myelination (GO:0042552)4.87475097
6locomotory exploration behavior (GO:0035641)4.77364699
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.60152850
8glutamate secretion (GO:0014047)4.46897822
9astrocyte differentiation (GO:0048708)4.40023626
10transmission of nerve impulse (GO:0019226)4.39231723
11cellular potassium ion homeostasis (GO:0030007)4.39115496
12neuron cell-cell adhesion (GO:0007158)4.36807627
13synaptic vesicle maturation (GO:0016188)4.22153504
14oligodendrocyte differentiation (GO:0048709)4.17427746
15sodium ion export (GO:0071436)4.03990776
16regulation of somitogenesis (GO:0014807)4.01229223
17peripheral nervous system axon ensheathment (GO:0032292)3.90093359
18myelination in peripheral nervous system (GO:0022011)3.90093359
19potassium ion import (GO:0010107)3.89803923
20L-amino acid import (GO:0043092)3.89604842
21potassium ion homeostasis (GO:0055075)3.87508745
22fatty acid elongation (GO:0030497)3.85661694
23regulation of neuronal synaptic plasticity (GO:0048168)3.83726052
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81951699
25cell aggregation (GO:0098743)3.80027127
26cartilage condensation (GO:0001502)3.80027127
27photoreceptor cell differentiation (GO:0046530)3.76429955
28eye photoreceptor cell differentiation (GO:0001754)3.76429955
29negative regulation of neurotransmitter secretion (GO:0046929)3.75664343
30presynaptic membrane assembly (GO:0097105)3.72063499
31neurotransmitter uptake (GO:0001504)3.70177158
32adenosine receptor signaling pathway (GO:0001973)3.61332253
33auditory receptor cell differentiation (GO:0042491)3.59526664
34axon development (GO:0061564)3.50671608
35negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.49848644
36acidic amino acid transport (GO:0015800)3.46991402
37glycerophospholipid catabolic process (GO:0046475)3.42038591
38negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.41859192
39amino acid import (GO:0043090)3.41439871
40positive regulation of neurological system process (GO:0031646)3.35048398
41cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34717742
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29386546
43cerebellar granule cell differentiation (GO:0021707)3.29230895
44negative regulation of neurotransmitter transport (GO:0051589)3.26858921
45presynaptic membrane organization (GO:0097090)3.26054408
46substantia nigra development (GO:0021762)3.24067326
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23593410
48asymmetric protein localization (GO:0008105)3.23411463
49regulation of hydrogen peroxide-induced cell death (GO:1903205)3.22989782
50regulation of synaptic vesicle transport (GO:1902803)3.22455671
51negative regulation of inclusion body assembly (GO:0090084)3.16889806
52neuronal ion channel clustering (GO:0045161)3.16825874
53dendritic spine morphogenesis (GO:0060997)3.14958847
54long-term synaptic potentiation (GO:0060291)3.13406218
55regulation of synapse structural plasticity (GO:0051823)3.12771063
56L-glutamate transport (GO:0015813)3.12387770
57exploration behavior (GO:0035640)3.12069779
58negative regulation of response to reactive oxygen species (GO:1901032)3.11745910
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10954465
60long-chain fatty acid biosynthetic process (GO:0042759)3.09343898
61limb bud formation (GO:0060174)3.09158247
62neurotransmitter secretion (GO:0007269)3.08706770
63apical protein localization (GO:0045176)3.08321340
64lateral sprouting from an epithelium (GO:0060601)3.04869313
65dermatan sulfate biosynthetic process (GO:0030208)3.01821149
66glial cell development (GO:0021782)2.99470252
67protein localization to synapse (GO:0035418)2.98647034
68neurotransmitter-gated ion channel clustering (GO:0072578)2.98589652
69neuronal action potential propagation (GO:0019227)2.97858191
70regulation of synaptic plasticity (GO:0048167)2.97469430
71extracellular matrix assembly (GO:0085029)2.96384564
72protein polyglutamylation (GO:0018095)2.96151379
73peripheral nervous system development (GO:0007422)2.92342895
74negative regulation of axon extension (GO:0030517)2.90648965
75dermatan sulfate metabolic process (GO:0030205)2.89019387
76L-serine transport (GO:0015825)2.88101365
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87335827
78regulation of catecholamine metabolic process (GO:0042069)2.86166914
79regulation of dopamine metabolic process (GO:0042053)2.86166914
80regulation of cholesterol biosynthetic process (GO:0045540)2.86038263
81neuron recognition (GO:0008038)2.84069795
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84059831
83neuromuscular process controlling balance (GO:0050885)2.82963274
84regulation of sensory perception of pain (GO:0051930)2.81898811
85regulation of sensory perception (GO:0051931)2.81898811
86cholesterol biosynthetic process (GO:0006695)2.81566603
87negative regulation of axonogenesis (GO:0050771)2.80802018
88positive regulation of dendritic spine development (GO:0060999)2.80674623
89synaptic vesicle exocytosis (GO:0016079)2.80673168
90positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80606903
91positive regulation of action potential (GO:0045760)2.79281732
92dendrite morphogenesis (GO:0048813)2.78885965
93regulation of inclusion body assembly (GO:0090083)2.78875719
94lens fiber cell development (GO:0070307)2.77884068
95glycosphingolipid biosynthetic process (GO:0006688)2.76323391
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75726045
97regulation of collateral sprouting (GO:0048670)2.74612299
98chondroitin sulfate catabolic process (GO:0030207)2.72552441
99astrocyte development (GO:0014002)2.72144524
100cGMP-mediated signaling (GO:0019934)2.72123005
101sensory perception of mechanical stimulus (GO:0050954)2.71768798
102regulation of female receptivity (GO:0045924)2.71227426
103sensory perception of sound (GO:0007605)2.71134945
104regulation of glutamate receptor signaling pathway (GO:1900449)2.70676208
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70119545
106cell communication by electrical coupling (GO:0010644)2.69564694
107negative regulation of astrocyte differentiation (GO:0048712)2.69172041
108neuron projection regeneration (GO:0031102)2.68847802
109relaxation of smooth muscle (GO:0044557)2.67718672
110response to redox state (GO:0051775)2.67444119
111righting reflex (GO:0060013)2.67343955
112neurotransmitter transport (GO:0006836)2.67212851
113oligodendrocyte development (GO:0014003)2.66295782
114cellular sodium ion homeostasis (GO:0006883)2.66126797
115response to lead ion (GO:0010288)2.66122652
116peptidyl-tyrosine autophosphorylation (GO:0038083)2.65604274
117regulation of voltage-gated calcium channel activity (GO:1901385)2.64856202
118regulation of neurotransmitter levels (GO:0001505)2.64831720
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63975152
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63796521
121inner ear receptor cell differentiation (GO:0060113)2.63236186
122cellular response to monoamine stimulus (GO:0071868)2.62214229
123cellular response to catecholamine stimulus (GO:0071870)2.62214229
124myelin maintenance (GO:0043217)2.61903283
125positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60452496
126bone trabecula formation (GO:0060346)2.59842899
127vocalization behavior (GO:0071625)2.59839465
128positive regulation of synapse assembly (GO:0051965)2.58990502
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58716945
130L-phenylalanine catabolic process (GO:0006559)2.58716945
131cell migration in hindbrain (GO:0021535)2.58386331
132regulation of ARF protein signal transduction (GO:0032012)2.58085689
133endocardial cushion morphogenesis (GO:0003203)2.57485806
134neurotransmitter catabolic process (GO:0042135)2.57366528
135axonal fasciculation (GO:0007413)2.56092897
136mechanoreceptor differentiation (GO:0042490)2.55540423
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55304907
138adult walking behavior (GO:0007628)2.55181596
139layer formation in cerebral cortex (GO:0021819)2.53734812
140cell-cell junction maintenance (GO:0045217)2.51067249
141ionotropic glutamate receptor signaling pathway (GO:0035235)2.50212867
142postsynaptic membrane organization (GO:0001941)2.50176386
143regulation of synaptic vesicle exocytosis (GO:2000300)2.49426525
144synapse organization (GO:0050808)2.48416333
145establishment of mitochondrion localization (GO:0051654)2.46610998
146glial cell differentiation (GO:0010001)2.46068979
147cerebral cortex radially oriented cell migration (GO:0021799)2.45695173
148positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.44900216
149C4-dicarboxylate transport (GO:0015740)2.44270647
150negative regulation of protein localization to cell surface (GO:2000009)2.44190258
151chondrocyte development (GO:0002063)2.44080647
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42546334
153neuroblast proliferation (GO:0007405)2.42163604
154synaptic transmission, glutamatergic (GO:0035249)2.41362873
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.40776565
156neural nucleus development (GO:0048857)2.38167847
157response to methylmercury (GO:0051597)2.37968792
158activated T cell proliferation (GO:0050798)2.37499899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.33929964
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.97216709
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89049014
4EZH2_22144423_ChIP-Seq_EOC_Human2.86084242
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82950372
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76896499
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71438284
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71438284
9AR_21572438_ChIP-Seq_LNCaP_Human2.67379778
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.59468079
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55621857
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52671026
13GBX2_23144817_ChIP-Seq_PC3_Human2.47842769
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46513185
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46423430
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46306713
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35311876
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33443867
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.31792741
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31439195
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31363486
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27337790
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98564554
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94633304
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89554802
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89375840
27DROSHA_22980978_ChIP-Seq_HELA_Human1.88482034
28* LXR_22292898_ChIP-Seq_THP-1_Human1.72369282
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71922401
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70836020
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70122611
32REST_21632747_ChIP-Seq_MESCs_Mouse1.68092995
33* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63162626
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.54530327
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54423077
36TAF15_26573619_Chip-Seq_HEK293_Human1.51561931
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48089997
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47020371
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46593576
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.45044121
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44965480
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.44099493
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43154330
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42992542
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40112093
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39364660
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36757681
48CTCF_27219007_Chip-Seq_Bcells_Human1.35817445
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.35745865
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35562912
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35038821
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34986049
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.34697770
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.32422456
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30805338
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30144789
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29719984
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28285015
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28161729
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26095723
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24739095
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24078207
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21737647
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21223418
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20844584
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20483781
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20088185
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19981002
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18779056
70SMC4_20622854_ChIP-Seq_HELA_Human1.17890886
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.15997406
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14126473
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.14062732
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12842513
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12300456
76AHR_22903824_ChIP-Seq_MCF-7_Human1.11117942
77OCT4_19829295_ChIP-Seq_ESCs_Human1.11112411
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08218710
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08109146
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07912523
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07912523
82MITF_21258399_ChIP-Seq_MELANOMA_Human1.07579812
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06726587
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.06366277
85SMAD4_21799915_ChIP-Seq_A2780_Human1.06230971
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06206085
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05387260
88STAT3_23295773_ChIP-Seq_U87_Human1.05307667
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04528045
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02261273
91ER_23166858_ChIP-Seq_MCF-7_Human1.02071136
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01369740
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.00840438
94P300_19829295_ChIP-Seq_ESCs_Human1.00581169
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.00544248
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00424600
97KDM2B_26808549_Chip-Seq_DND41_Human0.99141881
98TP53_23651856_ChIP-Seq_MEFs_Mouse0.98971056
99VDR_22108803_ChIP-Seq_LS180_Human0.98750019
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97442101
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97247361
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96862325
103DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96296849
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95666679
105P68_20966046_ChIP-Seq_HELA_Human0.95058381
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94987890
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94628511
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94476508
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94214607
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93213999
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92950432
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.92146522
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.91949184
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90808451
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90703684
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90488868
117* RNF2_27304074_Chip-Seq_NSC_Mouse0.90392095
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90310943
119AR_19668381_ChIP-Seq_PC3_Human0.90023681
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90001384
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89817565
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89086234
123* CTCF_20526341_ChIP-Seq_ESCs_Human0.88154197
124FUS_26573619_Chip-Seq_HEK293_Human0.87778731
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87242604
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.87178376
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86279346
128TP53_18474530_ChIP-ChIP_U2OS_Human0.84647388
129KDM2B_26808549_Chip-Seq_K562_Human0.84633090
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84497784
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.83670914
132TCF4_23295773_ChIP-Seq_U87_Human0.83396883
133EOMES_21245162_ChIP-Seq_HESCs_Human0.82848690
134MYC_19915707_ChIP-ChIP_AK7_Human0.82037039
135DPY_21335234_ChIP-Seq_ESCs_Mouse0.80945736
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.78798426
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78003541
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77632802
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.77261016
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.77261016
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76975572
142KLF4_19829295_ChIP-Seq_ESCs_Human0.75839550
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75482846
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.73879488
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73427195
146HTT_18923047_ChIP-ChIP_STHdh_Human0.73413839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell3.69603954
2MP0001485_abnormal_pinna_reflex3.68292198
3MP0003880_abnormal_central_pattern3.03187954
4MP0004859_abnormal_synaptic_plasticity2.82691729
5MP0001963_abnormal_hearing_physiology2.82140650
6MP0004885_abnormal_endolymph2.82046320
7MP0001486_abnormal_startle_reflex2.78788507
8MP0005377_hearing/vestibular/ear_phenot2.78384860
9MP0003878_abnormal_ear_physiology2.78384860
10MP0000920_abnormal_myelination2.73069345
11MP0004270_analgesia2.57427708
12MP0000026_abnormal_inner_ear2.53753505
13MP0003329_amyloid_beta_deposits2.29147516
14MP0004134_abnormal_chest_morphology2.27869474
15MP0002272_abnormal_nervous_system2.26864168
16MP0004742_abnormal_vestibular_system2.21361577
17MP0003633_abnormal_nervous_system2.16756574
18MP0003635_abnormal_synaptic_transmissio2.08936371
19MP0003631_nervous_system_phenotype2.06385960
20MP0002064_seizures2.00146235
21MP0000778_abnormal_nervous_system1.89925393
22MP0003136_yellow_coat_color1.88976613
23MP0003690_abnormal_glial_cell1.85341029
24MP0009046_muscle_twitch1.79964267
25MP0009780_abnormal_chondrocyte_physiolo1.79682002
26MP0003634_abnormal_glial_cell1.78560678
27MP0002734_abnormal_mechanical_nocicepti1.77953505
28MP0005171_absent_coat_pigmentation1.77184273
29MP0001299_abnormal_eye_distance/1.76778522
30MP0005167_abnormal_blood-brain_barrier1.76276458
31MP0009745_abnormal_behavioral_response1.67879371
32MP0000462_abnormal_digestive_system1.64204352
33MP0005058_abnormal_lysosome_morphology1.60999153
34MP0002063_abnormal_learning/memory/cond1.55975144
35MP0002572_abnormal_emotion/affect_behav1.55288620
36MP0001529_abnormal_vocalization1.54717281
37MP0005623_abnormal_meninges_morphology1.49558613
38MP0009384_cardiac_valve_regurgitation1.49450381
39MP0009250_abnormal_appendicular_skeleto1.47368865
40MP0000955_abnormal_spinal_cord1.45872422
41MP0002229_neurodegeneration1.45419783
42MP0002882_abnormal_neuron_morphology1.45382710
43MP0004142_abnormal_muscle_tone1.44959922
44MP0004858_abnormal_nervous_system1.42605472
45MP0005503_abnormal_tendon_morphology1.42496617
46MP0002752_abnormal_somatic_nervous1.41124105
47MP0002067_abnormal_sensory_capabilities1.41021377
48MP0002184_abnormal_innervation1.40359097
49MP0002282_abnormal_trachea_morphology1.38957067
50MP0003075_altered_response_to1.35524711
51MP0001440_abnormal_grooming_behavior1.34832228
52MP0002089_abnormal_postnatal_growth/wei1.32447670
53MP0003938_abnormal_ear_development1.30096014
54MP0001905_abnormal_dopamine_level1.30080617
55MP0001501_abnormal_sleep_pattern1.29624115
56MP0002733_abnormal_thermal_nociception1.28940467
57MP0008569_lethality_at_weaning1.28555037
58MP0005423_abnormal_somatic_nervous1.27800798
59MP0001968_abnormal_touch/_nociception1.27365066
60MP0000747_muscle_weakness1.26720001
61MP0004811_abnormal_neuron_physiology1.24372968
62MP0003172_abnormal_lysosome_physiology1.22526055
63MP0002653_abnormal_ependyma_morphology1.22446499
64MP0000762_abnormal_tongue_morphology1.18943287
65MP0005551_abnormal_eye_electrophysiolog1.18542760
66MP0001970_abnormal_pain_threshold1.17347767
67MP0003632_abnormal_nervous_system1.16693927
68MP0000534_abnormal_ureter_morphology1.15673645
69MP0004272_abnormal_basement_membrane1.12369595
70MP0000049_abnormal_middle_ear1.11837729
71MP0005646_abnormal_pituitary_gland1.11400093
72MP0006072_abnormal_retinal_apoptosis1.10225835
73MP0002066_abnormal_motor_capabilities/c1.09947904
74MP0008438_abnormal_cutaneous_collagen1.08600992
75MP0000569_abnormal_digit_pigmentation1.06481135
76MP0000751_myopathy1.05634295
77MP0004924_abnormal_behavior1.04619390
78MP0005386_behavior/neurological_phenoty1.04619390
79MP0002557_abnormal_social/conspecific_i1.04371401
80MP0000566_synostosis1.04090728
81MP0002735_abnormal_chemical_nociception1.03456317
82MP0000383_abnormal_hair_follicle1.03291290
83MP0005508_abnormal_skeleton_morphology1.03143358
84MP0000631_abnormal_neuroendocrine_gland1.02565368
85MP0000163_abnormal_cartilage_morphology1.02056393
86MP0006276_abnormal_autonomic_nervous1.01343457
87MP0001984_abnormal_olfaction0.98781843
88MP0009840_abnormal_foam_cell0.97063184
89MP0001986_abnormal_taste_sensitivity0.96688581
90MP0002736_abnormal_nociception_after0.96638518
91MP0000579_abnormal_nail_morphology0.96109703
92MP0002152_abnormal_brain_morphology0.95822690
93MP0001502_abnormal_circadian_rhythm0.94756780
94MP0002933_joint_inflammation0.94271587
95MP0010678_abnormal_skin_adnexa0.93369364
96MP0002822_catalepsy0.93312419
97MP0002249_abnormal_larynx_morphology0.93178591
98MP0000604_amyloidosis0.92818743
99MP0006082_CNS_inflammation0.90541302
100MP0003122_maternal_imprinting0.87815186
101MP0002108_abnormal_muscle_morphology0.87787747
102MP0005195_abnormal_posterior_eye0.86918259
103MP0003283_abnormal_digestive_organ0.86477507
104MP0005645_abnormal_hypothalamus_physiol0.86437009
105MP0008260_abnormal_autophagy0.85654034
106MP0004381_abnormal_hair_follicle0.84611619
107MP0003937_abnormal_limbs/digits/tail_de0.83733333
108MP0002116_abnormal_craniofacial_bone0.83449431
109MP0008874_decreased_physiological_sensi0.83072280
110MP0002115_abnormal_skeleton_extremities0.82268507
111MP0003950_abnormal_plasma_membrane0.80796600
112MP0000428_abnormal_craniofacial_morphol0.80641272
113MP0002233_abnormal_nose_morphology0.80528135
114MP0000015_abnormal_ear_pigmentation0.80000906
115MP0000749_muscle_degeneration0.79694576
116MP0003942_abnormal_urinary_system0.79308209
117MP0001177_atelectasis0.77603240
118MP0002909_abnormal_adrenal_gland0.75620600
119MP0004130_abnormal_muscle_cell0.75215398
120MP0005253_abnormal_eye_physiology0.75165837
121MP0002102_abnormal_ear_morphology0.75118277
122MP0003755_abnormal_palate_morphology0.75074120
123MP0003861_abnormal_nervous_system0.74945708
124MP0005535_abnormal_body_temperature0.69079104
125MP0003787_abnormal_imprinting0.66425835
126MP0005409_darkened_coat_color0.66349260
127MP0005174_abnormal_tail_pigmentation0.65933461
128MP0005464_abnormal_platelet_physiology0.63860318
129MP0000639_abnormal_adrenal_gland0.63129305
130MP0001958_emphysema0.62647926
131MP0002295_abnormal_pulmonary_circulatio0.61750461
132MP0003183_abnormal_peptide_metabolism0.58619913
133MP0003638_abnormal_response/metabolism_0.54985403
134MP0003191_abnormal_cellular_cholesterol0.53888543
135MP0004510_myositis0.53345020
136MP0005670_abnormal_white_adipose0.52821514
137MP0001346_abnormal_lacrimal_gland0.51773503
138MP0002638_abnormal_pupillary_reflex0.49650161
139MP0002069_abnormal_eating/drinking_beha0.48523181

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.76643110
2Irregular epiphyses (HP:0010582)6.33103289
3Scanning speech (HP:0002168)5.43045857
4Small epiphyses (HP:0010585)5.29404327
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.27910152
6Hypoplastic ischia (HP:0003175)5.14333432
7Vitreoretinal degeneration (HP:0000655)4.92797253
8Mixed hearing impairment (HP:0000410)4.58291837
9Abnormality of the ischium (HP:0003174)4.49734596
10Delayed epiphyseal ossification (HP:0002663)4.05471492
11Mild short stature (HP:0003502)4.02525480
12Abnormality of binocular vision (HP:0011514)3.95138296
13Diplopia (HP:0000651)3.95138296
14Focal motor seizures (HP:0011153)3.84090928
15Absent epiphyses (HP:0010577)3.64683627
16Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.64683627
17Stridor (HP:0010307)3.55664611
18Neurofibrillary tangles (HP:0002185)3.45268370
19Genu varum (HP:0002970)3.40944782
20Peripheral hypomyelination (HP:0007182)3.33345893
21Severe Myopia (HP:0011003)3.28787083
22Bell-shaped thorax (HP:0001591)3.24849377
23Enlarged epiphyses (HP:0010580)3.21761106
24Focal seizures (HP:0007359)3.20817070
25Spastic tetraparesis (HP:0001285)3.17003310
26Abnormal eating behavior (HP:0100738)3.12910896
27Increased circulating renin level (HP:0000848)3.08058021
28Abnormality of the pubic bones (HP:0003172)3.07012489
29Flattened epiphyses (HP:0003071)3.06559557
30Osteoarthritis (HP:0002758)3.06378217
31Abnormality of the periventricular white matter (HP:0002518)3.04348000
32Synostosis involving the elbow (HP:0003938)2.90999324
33Humeroradial synostosis (HP:0003041)2.90999324
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89917297
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.89917297
36Vertebral clefting (HP:0008428)2.87000322
37Epileptic encephalopathy (HP:0200134)2.84166456
38Hypoplastic pelvis (HP:0008839)2.83632895
39Barrel-shaped chest (HP:0001552)2.79638978
40Abnormality of the vitreous humor (HP:0004327)2.79363237
41Protuberant abdomen (HP:0001538)2.77095405
42Urinary urgency (HP:0000012)2.76923620
43Abnormal vertebral ossification (HP:0100569)2.74471892
44Lower limb muscle weakness (HP:0007340)2.73096800
45Bowel incontinence (HP:0002607)2.72775416
46Anomalous pulmonary venous return (HP:0010772)2.71655561
47Choreoathetosis (HP:0001266)2.71557642
48Alacrima (HP:0000522)2.71159820
49Leukodystrophy (HP:0002415)2.70448775
50White forelock (HP:0002211)2.67947196
51Decreased motor nerve conduction velocity (HP:0003431)2.67921996
52Aplasia involving bones of the upper limbs (HP:0009823)2.67252512
53Aplasia of the phalanges of the hand (HP:0009802)2.67252512
54Aplasia involving bones of the extremities (HP:0009825)2.67252512
55Myokymia (HP:0002411)2.63936601
56Abnormal large intestine physiology (HP:0012700)2.63491094
57Febrile seizures (HP:0002373)2.61881265
58Obstructive sleep apnea (HP:0002870)2.58294939
59Sensory axonal neuropathy (HP:0003390)2.56573266
60Abnormality of the vertebral endplates (HP:0005106)2.54294864
61Neuronal loss in central nervous system (HP:0002529)2.51129289
62Abnormality of the corticospinal tract (HP:0002492)2.50521530
63Cerebral inclusion bodies (HP:0100314)2.50248747
64Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.49078646
65Split foot (HP:0001839)2.46531817
66Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.43175792
67Abnormality of femoral epiphyses (HP:0006499)2.43175792
68Rigidity (HP:0002063)2.40923516
69Abnormal tarsal ossification (HP:0008369)2.40491957
70Generalized tonic-clonic seizures (HP:0002069)2.39583422
71Dysdiadochokinesis (HP:0002075)2.37874111
72Rapidly progressive (HP:0003678)2.36744268
73Termporal pattern (HP:0011008)2.36592272
74Insidious onset (HP:0003587)2.36592272
75Akinesia (HP:0002304)2.35600503
76Paraparesis (HP:0002385)2.34324610
77Patchy hypopigmentation of hair (HP:0011365)2.33824159
78Abnormality of the femoral head (HP:0003368)2.33434831
79Delusions (HP:0000746)2.33226199
80Postural instability (HP:0002172)2.33128008
81Abnormality of the epiphysis of the femoral head (HP:0010574)2.32983979
82Supranuclear gaze palsy (HP:0000605)2.32322275
83CNS hypomyelination (HP:0003429)2.31693050
84Limb dystonia (HP:0002451)2.30536372
85Short femoral neck (HP:0100864)2.29981019
86Abnormality of the middle phalanges of the toes (HP:0010183)2.29293688
87Relative macrocephaly (HP:0004482)2.27788061
88Abnormality of the pulmonary veins (HP:0011718)2.27065543
89Visual hallucinations (HP:0002367)2.26989015
90Torticollis (HP:0000473)2.26675232
91Flat capital femoral epiphysis (HP:0003370)2.26102278
92Cupped ribs (HP:0000887)2.24240785
93Morphological abnormality of the inner ear (HP:0011390)2.21997426
94Action tremor (HP:0002345)2.20417262
95Muscle fiber splitting (HP:0003555)2.20162092
96Truncal ataxia (HP:0002078)2.19828499
97Cerebral hypomyelination (HP:0006808)2.19657920
98Bundle branch block (HP:0011710)2.16662722
99Clonus (HP:0002169)2.16287798
100Neonatal short-limb short stature (HP:0008921)2.16281627
101Apathy (HP:0000741)2.15844496
102Hyporeflexia of lower limbs (HP:0002600)2.15419744
103Foot dorsiflexor weakness (HP:0009027)2.15244746
104Abnormal auditory evoked potentials (HP:0006958)2.14694588
105Turricephaly (HP:0000262)2.14685180
106Megalencephaly (HP:0001355)2.14340348
107Platyspondyly (HP:0000926)2.12799268
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.10712003
109Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10435165
110Achilles tendon contracture (HP:0001771)2.10137313
111Lower limb hyperreflexia (HP:0002395)2.09734475
112Morphological abnormality of the pyramidal tract (HP:0002062)2.09257738
113Hypoplasia of the iris (HP:0007676)2.07574825
114Polyphagia (HP:0002591)2.06602358
115Limited hip movement (HP:0008800)2.06473428
116Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06072715
117Abnormality of the Achilles tendon (HP:0005109)2.05636073
118Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03851446
119Decreased lacrimation (HP:0000633)2.02020878
120Urinary incontinence (HP:0000020)2.00428839
121Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.99988982
122Insomnia (HP:0100785)1.99725820
123Glossoptosis (HP:0000162)1.99004107
124Abnormality of the foot musculature (HP:0001436)1.98375220
125Abnormality of incisor morphology (HP:0011063)1.97766864
126Diminished motivation (HP:0000745)1.96682740
127Flat acetabular roof (HP:0003180)1.96438533
128Distal sensory impairment (HP:0002936)1.94748360
129Depression (HP:0000716)1.93479895
130Blue irides (HP:0000635)1.92488327
131Spastic gait (HP:0002064)1.92314932
132Difficulty walking (HP:0002355)1.92270710
133Heterochromia iridis (HP:0001100)1.92239788
134Mutism (HP:0002300)1.91721736
135Sleep apnea (HP:0010535)1.90301025
136Memory impairment (HP:0002354)1.89472339
137Papilledema (HP:0001085)1.87876621
138Urinary bladder sphincter dysfunction (HP:0002839)1.86629187
139Onion bulb formation (HP:0003383)1.86623416
140Parakeratosis (HP:0001036)1.86567238
141Irregular vertebral endplates (HP:0003301)1.86034758
142Slow saccadic eye movements (HP:0000514)1.85942081
143Postural tremor (HP:0002174)1.85730540
144Ocular albinism (HP:0001107)1.85324022
145Annular pancreas (HP:0001734)1.85269408
146Hemiparesis (HP:0001269)1.84343616
147Waddling gait (HP:0002515)1.83471447
148Atonic seizures (HP:0010819)1.81547565
149Premature skin wrinkling (HP:0100678)1.80766673
150Aplasia/hypoplasia of the femur (HP:0005613)1.80382773
151Dysmetria (HP:0001310)1.79822618
152Disproportionate short-trunk short stature (HP:0003521)1.79325639
153Congenital sensorineural hearing impairment (HP:0008527)1.74949987
154Hypoplasia of the odontoid process (HP:0003311)1.72682230
155Oligodactyly (hands) (HP:0001180)1.70963198
156Metaphyseal dysplasia (HP:0100255)1.69324496
157Adrenal hypoplasia (HP:0000835)1.68112118
158Intention tremor (HP:0002080)1.68107959
159Meningocele (HP:0002435)1.67047130
160Micromelia (HP:0002983)1.65426493
161Ankle clonus (HP:0011448)1.65401972
162Exostoses (HP:0100777)1.64644406
163Rhizomelia (HP:0008905)1.63384521
164Synostosis of carpal bones (HP:0005048)1.62541253
165Coronal craniosynostosis (HP:0004440)1.60784210
166Recurrent corneal erosions (HP:0000495)1.60389942
167Arthropathy (HP:0003040)1.60297554
168Spastic paraparesis (HP:0002313)1.58611405
169Metaphyseal irregularity (HP:0003025)1.58227649
170Hammertoe (HP:0001765)1.57496859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.16438617
2STK394.12364113
3TNIK3.30409766
4OXSR12.86615624
5EPHB12.76020398
6EPHA42.46054146
7ICK2.28912072
8PRPF4B2.23665191
9TYRO32.20031850
10WNK42.18945139
11NTRK12.11155156
12PAK61.80009449
13UHMK11.77224095
14DAPK21.76436777
15MARK11.71258818
16BCR1.70726463
17NTRK31.69725491
18PNCK1.68848369
19CDK191.66247366
20PRKD31.65499173
21CASK1.58124268
22DAPK31.56998235
23NTRK21.56362126
24PHKG11.55275424
25PHKG21.55275424
26MAP3K91.51207814
27ILK1.49261704
28PAK31.47001030
29MET1.44990315
30PRKD11.44288052
31PKN11.34394094
32RIPK41.33504627
33KSR21.32607952
34MAPK151.30046820
35RIPK11.29873114
36WNK11.29162065
37CSNK1A1L1.27100446
38PBK1.23834476
39NEK61.22218418
40ROCK21.19931555
41ARAF1.18792294
42CSNK1G31.17912229
43MAPK131.17116438
44GRK51.11451713
45IRAK21.09615920
46CSNK1G21.09473186
47MAPK121.08021237
48CDK51.06766911
49CSNK1G10.98275773
50IRAK10.98186482
51FGR0.96710737
52CAMK10.94135519
53FES0.92631298
54LIMK10.91615484
55MAP3K110.86544813
56MARK20.85618187
57MINK10.85212596
58ERBB40.84629636
59SGK4940.83978757
60SGK2230.83978757
61MAP3K20.82121996
62SIK20.82083432
63CDK140.81848635
64ALK0.81657297
65PINK10.81333760
66FGFR20.80707155
67KSR10.77492800
68SGK20.76930284
69MAPKAPK50.73632874
70CAMK1G0.71661587
71STK380.71212456
72PRKG10.70384118
73PRKCG0.69116854
74CAMK2B0.67529075
75TESK10.67339388
76PDK20.66922441
77DYRK1A0.66270949
78PDK10.65934794
79RAF10.65296900
80SGK10.64973845
81SIK10.64003560
82CAMK2A0.63621498
83SGK30.62482313
84CDK150.61363714
85RPS6KA30.59383533
86MAP3K40.58729252
87ROCK10.57650966
88CDK180.57031933
89PAK10.56368509
90CAMK2D0.55449814
91MAP3K10.55122037
92PRKCE0.54932079
93RET0.54413469
94LMTK20.53721559
95MAP2K70.53589622
96TNK20.53327972
97LATS10.53043514
98CDK11A0.52979798
99NME10.51670522
100FYN0.50622991
101PDGFRB0.50401231
102PLK20.50100486
103TRPM70.49642480
104PRKCH0.48683664
105DYRK20.46748212
106PDGFRA0.45260695
107PDPK10.44566129
108EPHA30.43399615
109PRKCQ0.42778601
110SRC0.42372593
111BMX0.42149470
112MAPK70.42066781
113CAMK2G0.41992478
114CAMKK20.40002513
115PRKD20.39638489
116PRKACG0.39467417
117ERBB20.39349122
118DMPK0.39259583
119PTK20.39256276
120TESK20.39131430
121PRKCA0.38785649
122MAPK100.38296711
123DAPK10.37421406
124CAMKK10.37293754
125TRIB30.36979233
126PRKACA0.36462375
127MYLK0.36306503
128FGFR10.35628728
129LATS20.35584225
130BMPR20.35153065
131PRKCZ0.34892136
132GSK3A0.33744845
133DYRK1B0.32890147
134PTK2B0.32279018
135STK110.31869324
136CSNK1D0.30690319

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.85580726
2Histidine metabolism_Homo sapiens_hsa003403.24887635
3Steroid biosynthesis_Homo sapiens_hsa001002.85527272
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57591213
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40092742
6Axon guidance_Homo sapiens_hsa043602.34690418
7beta-Alanine metabolism_Homo sapiens_hsa004102.14929015
8Fatty acid elongation_Homo sapiens_hsa000622.04370125
9Nicotine addiction_Homo sapiens_hsa050331.95138740
10Protein digestion and absorption_Homo sapiens_hsa049741.89435426
11Glutamatergic synapse_Homo sapiens_hsa047241.89152948
12ECM-receptor interaction_Homo sapiens_hsa045121.87004414
13Ether lipid metabolism_Homo sapiens_hsa005651.82614939
14GABAergic synapse_Homo sapiens_hsa047271.76146225
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.75656342
16Long-term depression_Homo sapiens_hsa047301.64736535
17Dorso-ventral axis formation_Homo sapiens_hsa043201.60840735
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60419493
19Synaptic vesicle cycle_Homo sapiens_hsa047211.57996809
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54394388
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50466973
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45823652
23Sphingolipid metabolism_Homo sapiens_hsa006001.43055241
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42436514
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40696880
26Bile secretion_Homo sapiens_hsa049761.40445436
27Morphine addiction_Homo sapiens_hsa050321.38741814
28Circadian entrainment_Homo sapiens_hsa047131.38455273
29Cocaine addiction_Homo sapiens_hsa050301.38326871
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37296259
31Serotonergic synapse_Homo sapiens_hsa047261.37196556
32Cholinergic synapse_Homo sapiens_hsa047251.35107064
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35103524
34Salivary secretion_Homo sapiens_hsa049701.28540123
35Olfactory transduction_Homo sapiens_hsa047401.28307239
36Renal cell carcinoma_Homo sapiens_hsa052111.25309355
37Hedgehog signaling pathway_Homo sapiens_hsa043401.23242552
38Hippo signaling pathway_Homo sapiens_hsa043901.22947919
39Dopaminergic synapse_Homo sapiens_hsa047281.21631924
40ErbB signaling pathway_Homo sapiens_hsa040121.20697862
41Amphetamine addiction_Homo sapiens_hsa050311.20651161
42Fatty acid biosynthesis_Homo sapiens_hsa000611.20460173
43Basal cell carcinoma_Homo sapiens_hsa052171.18687191
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15754319
45Sulfur metabolism_Homo sapiens_hsa009201.14224187
46Long-term potentiation_Homo sapiens_hsa047201.12135324
47Gap junction_Homo sapiens_hsa045401.12117946
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09130270
49Vibrio cholerae infection_Homo sapiens_hsa051101.05624070
50Collecting duct acid secretion_Homo sapiens_hsa049661.04302263
51Insulin secretion_Homo sapiens_hsa049111.03905776
52Melanogenesis_Homo sapiens_hsa049161.03880897
53Wnt signaling pathway_Homo sapiens_hsa043101.01344678
54Butanoate metabolism_Homo sapiens_hsa006500.98681779
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98171153
56Gastric acid secretion_Homo sapiens_hsa049710.96737990
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.94421811
58Tight junction_Homo sapiens_hsa045300.93839634
59Choline metabolism in cancer_Homo sapiens_hsa052310.92530132
60Taste transduction_Homo sapiens_hsa047420.90918245
61Oxytocin signaling pathway_Homo sapiens_hsa049210.87327863
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86687554
63Focal adhesion_Homo sapiens_hsa045100.86126509
64Arginine biosynthesis_Homo sapiens_hsa002200.85903522
65TGF-beta signaling pathway_Homo sapiens_hsa043500.84837493
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81900394
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81144834
68GnRH signaling pathway_Homo sapiens_hsa049120.78521914
69Ovarian steroidogenesis_Homo sapiens_hsa049130.78249208
70Estrogen signaling pathway_Homo sapiens_hsa049150.75337520
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74718350
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.74119650
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73487929
74Calcium signaling pathway_Homo sapiens_hsa040200.72909048
75Ras signaling pathway_Homo sapiens_hsa040140.72787648
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72624640
77Rap1 signaling pathway_Homo sapiens_hsa040150.70660231
78Endocytosis_Homo sapiens_hsa041440.69635708
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69233654
80Nitrogen metabolism_Homo sapiens_hsa009100.69177660
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.69126683
82cAMP signaling pathway_Homo sapiens_hsa040240.68765251
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68703075
84Renin secretion_Homo sapiens_hsa049240.68519842
85Inositol phosphate metabolism_Homo sapiens_hsa005620.68341645
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68042607
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.66885327
88Fatty acid metabolism_Homo sapiens_hsa012120.66571704
89Pancreatic secretion_Homo sapiens_hsa049720.65717223
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65401491
91ABC transporters_Homo sapiens_hsa020100.65224610
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.65221144
93Folate biosynthesis_Homo sapiens_hsa007900.65211581
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.63773914
95VEGF signaling pathway_Homo sapiens_hsa043700.63597720
96Cardiac muscle contraction_Homo sapiens_hsa042600.63544190
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62784097
98Arginine and proline metabolism_Homo sapiens_hsa003300.61956375
99PPAR signaling pathway_Homo sapiens_hsa033200.61593565
100Dilated cardiomyopathy_Homo sapiens_hsa054140.60275350
101Lysosome_Homo sapiens_hsa041420.60036268
102Notch signaling pathway_Homo sapiens_hsa043300.59963455
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59491188
104Oxidative phosphorylation_Homo sapiens_hsa001900.57589627
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57291340
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55242120
107Glioma_Homo sapiens_hsa052140.54530801
108MAPK signaling pathway_Homo sapiens_hsa040100.54384625
109Prion diseases_Homo sapiens_hsa050200.54099491
110Protein export_Homo sapiens_hsa030600.52980345
111Vitamin B6 metabolism_Homo sapiens_hsa007500.51497421
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51160655
113Alzheimers disease_Homo sapiens_hsa050100.50823039
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49301182
115Proteoglycans in cancer_Homo sapiens_hsa052050.49200915
116Thyroid hormone synthesis_Homo sapiens_hsa049180.47851636
117Platelet activation_Homo sapiens_hsa046110.47685979
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46495967
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46400573
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45985346
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.45205152
122Linoleic acid metabolism_Homo sapiens_hsa005910.45181032
123Phenylalanine metabolism_Homo sapiens_hsa003600.43306612
124Mineral absorption_Homo sapiens_hsa049780.41024114
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40814485
126Tyrosine metabolism_Homo sapiens_hsa003500.40278791
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39407937
128Phototransduction_Homo sapiens_hsa047440.38701690
129Circadian rhythm_Homo sapiens_hsa047100.37783684
130Other glycan degradation_Homo sapiens_hsa005110.37460932

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