CHAF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.24414395
2doxorubicin metabolic process (GO:0044598)8.24414395
3daunorubicin metabolic process (GO:0044597)8.24414395
4protein localization to kinetochore (GO:0034501)6.34400430
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.80174831
6aminoglycoside antibiotic metabolic process (GO:0030647)5.22295597
7DNA replication checkpoint (GO:0000076)5.19380194
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.16528885
9regulation of telomere maintenance via telomerase (GO:0032210)5.05090404
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.05036112
11mitotic sister chromatid segregation (GO:0000070)5.02626422
12protein localization to chromosome, centromeric region (GO:0071459)4.90772608
13negative regulation of cell cycle G2/M phase transition (GO:1902750)4.86703909
14maintenance of protein location in nucleus (GO:0051457)4.79319704
15negative regulation of epidermis development (GO:0045683)4.78267866
16negative regulation of telomerase activity (GO:0051974)4.61995457
17rRNA transcription (GO:0009303)4.54543907
18DNA unwinding involved in DNA replication (GO:0006268)4.54243270
19histone H4-K12 acetylation (GO:0043983)4.48119204
20DNA replication initiation (GO:0006270)4.45427160
21positive regulation of DNA-dependent DNA replication (GO:2000105)4.44930360
22somite rostral/caudal axis specification (GO:0032525)4.41762412
23rRNA methylation (GO:0031167)4.40970354
24rRNA modification (GO:0000154)4.39752686
25nuclear pore complex assembly (GO:0051292)4.37284549
26negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.32027740
27histone H4-K8 acetylation (GO:0043982)4.31012276
28histone H4-K5 acetylation (GO:0043981)4.31012276
29sister chromatid segregation (GO:0000819)4.29171040
30heterochromatin organization (GO:0070828)4.28973674
31nuclear pore organization (GO:0006999)4.17851970
32regulation of response to osmotic stress (GO:0047484)4.11272122
33ribosome biogenesis (GO:0042254)4.03514307
34formation of translation preinitiation complex (GO:0001731)4.03276575
35regulation of translation in response to stress (GO:0043555)3.99865898
36negative regulation of telomere maintenance (GO:0032205)3.97924072
37negative regulation of epidermal cell differentiation (GO:0045605)3.91315713
38DNA duplex unwinding (GO:0032508)3.80720872
39DNA geometric change (GO:0032392)3.77548682
40muscle organ morphogenesis (GO:0048644)3.75321848
41replication fork processing (GO:0031297)3.75232710
42mitotic chromosome condensation (GO:0007076)3.73631460
43chromatin remodeling at centromere (GO:0031055)3.72901326
44DNA strand elongation involved in DNA replication (GO:0006271)3.70380233
45cullin deneddylation (GO:0010388)3.70159682
46regulation of MHC class I biosynthetic process (GO:0045343)3.67022987
47pseudouridine synthesis (GO:0001522)3.66750728
48notochord development (GO:0030903)3.61709402
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.60375681
50maturation of 5.8S rRNA (GO:0000460)3.57494789
51CENP-A containing nucleosome assembly (GO:0034080)3.54701633
52DNA strand elongation (GO:0022616)3.51869876
53regulation of apoptotic process involved in morphogenesis (GO:1902337)3.44868485
54telomere maintenance via semi-conservative replication (GO:0032201)3.42097930
55meiotic chromosome segregation (GO:0045132)3.39770023
56ribosomal small subunit biogenesis (GO:0042274)3.39315207
57mitochondrial respiratory chain complex assembly (GO:0033108)3.39261756
58protein deneddylation (GO:0000338)3.38093679
59mitochondrial RNA metabolic process (GO:0000959)3.38041734
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37110561
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.37110561
62NADH dehydrogenase complex assembly (GO:0010257)3.37110561
63ribonucleoprotein complex biogenesis (GO:0022613)3.36941711
64protein K6-linked ubiquitination (GO:0085020)3.36733593
65pore complex assembly (GO:0046931)3.35493533
66interferon-gamma production (GO:0032609)3.33914638
67protein complex biogenesis (GO:0070271)3.31593118
68translesion synthesis (GO:0019985)3.31172850
69regulation of cilium movement (GO:0003352)3.30032226
70DNA damage response, detection of DNA damage (GO:0042769)3.27770268
71recombinational repair (GO:0000725)3.27084186
72double-strand break repair via homologous recombination (GO:0000724)3.25538999
73regulation of mitochondrial translation (GO:0070129)3.25518177
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24944626
75behavioral response to nicotine (GO:0035095)3.24772813
76regulation of double-strand break repair (GO:2000779)3.21622975
77respiratory chain complex IV assembly (GO:0008535)3.21139076
78cytidine metabolic process (GO:0046087)3.19677151
79cytidine catabolic process (GO:0006216)3.19677151
80cytidine deamination (GO:0009972)3.19677151
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.19196564
82regulation of DNA-dependent DNA replication (GO:0090329)3.17788244
83mitotic nuclear envelope disassembly (GO:0007077)3.17746889
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.15755076
85histone H4-K16 acetylation (GO:0043984)3.15421851
86postreplication repair (GO:0006301)3.15276133
87histone exchange (GO:0043486)3.13691488
88quinone metabolic process (GO:1901661)3.13623471
89DNA deamination (GO:0045006)3.11879999
90telomere maintenance via telomere lengthening (GO:0010833)3.10503903
91transcription from mitochondrial promoter (GO:0006390)3.10311909
92regulation of telomere maintenance (GO:0032204)3.10134319
93regulation of DNA endoreduplication (GO:0032875)3.09490303
94mitotic recombination (GO:0006312)3.07455767
95DNA conformation change (GO:0071103)3.06917520
96DNA double-strand break processing (GO:0000729)3.06498548
97regulation of telomerase activity (GO:0051972)3.06058426
98nucleoside transmembrane transport (GO:1901642)3.05613795
99primitive streak formation (GO:0090009)3.04287490
100response to pheromone (GO:0019236)3.04194530
101pre-miRNA processing (GO:0031054)3.03375635
102mRNA stabilization (GO:0048255)3.00176778
103RNA stabilization (GO:0043489)3.00176778
104mitochondrial DNA replication (GO:0006264)2.99794541
105regulation of gene silencing by RNA (GO:0060966)2.99112737
106regulation of posttranscriptional gene silencing (GO:0060147)2.99112737
107regulation of gene silencing by miRNA (GO:0060964)2.99112737
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97347239
109cytochrome complex assembly (GO:0017004)2.94754643
110pteridine-containing compound biosynthetic process (GO:0042559)2.94531317
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93908274
112telomere maintenance via recombination (GO:0000722)2.93895031
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93508038
114mitotic G2/M transition checkpoint (GO:0044818)2.92146751
115nuclear envelope disassembly (GO:0051081)2.90747262
116membrane disassembly (GO:0030397)2.90747262
117intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.89989119
118reciprocal meiotic recombination (GO:0007131)2.87560606
119reciprocal DNA recombination (GO:0035825)2.87560606
120purine nucleobase biosynthetic process (GO:0009113)2.87388278
121mitotic metaphase plate congression (GO:0007080)2.87086460
122spindle assembly (GO:0051225)2.87053175
123attachment of spindle microtubules to kinetochore (GO:0008608)2.86753579
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85442535
125regulation of mitotic spindle checkpoint (GO:1903504)2.85442535
126IMP biosynthetic process (GO:0006188)2.84672757
127GDP-mannose metabolic process (GO:0019673)2.84281806
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84006624
129* DNA replication-dependent nucleosome assembly (GO:0006335)2.83982139
130* DNA replication-dependent nucleosome organization (GO:0034723)2.83982139
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.83714848
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83714848
133branching involved in mammary gland duct morphogenesis (GO:0060444)2.83638945
134folic acid-containing compound biosynthetic process (GO:0009396)2.83354170
135nucleobase biosynthetic process (GO:0046112)2.83069568
136proteasome assembly (GO:0043248)2.82044047
137DNA replication-independent nucleosome organization (GO:0034724)2.80745555
138DNA replication-independent nucleosome assembly (GO:0006336)2.80745555
139transcription-coupled nucleotide-excision repair (GO:0006283)2.79972826
140protein localization to chromosome (GO:0034502)2.79099309
141DNA strand renaturation (GO:0000733)2.76496226
142apoptotic DNA fragmentation (GO:0006309)2.76321870
143synapsis (GO:0007129)2.76053858
144ubiquinone biosynthetic process (GO:0006744)2.76043572
145rRNA processing (GO:0006364)2.75284648
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74228702
147cell fate commitment involved in formation of primary germ layer (GO:0060795)2.73747661
148DNA recombination (GO:0006310)2.72954295
149rRNA catabolic process (GO:0016075)2.72749282
150rRNA metabolic process (GO:0016072)2.72379063
151regulation of centriole replication (GO:0046599)2.71875260
152tRNA processing (GO:0008033)2.71829759
153regulation of centrosome cycle (GO:0046605)2.70595289
154somatic diversification of immunoglobulins (GO:0016445)2.70552712
155DNA catabolic process, exonucleolytic (GO:0000738)2.70420812
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70204974
157protein-cofactor linkage (GO:0018065)2.69459376
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69450186
159ATP synthesis coupled proton transport (GO:0015986)2.69450186
160maturation of SSU-rRNA (GO:0030490)2.69030623
161L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68634387
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66219455
163somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66219455
164isotype switching (GO:0045190)2.66219455
165centriole replication (GO:0007099)2.64350012
166spliceosomal snRNP assembly (GO:0000387)2.63512372
167fucose catabolic process (GO:0019317)2.63232963
168L-fucose metabolic process (GO:0042354)2.63232963
169L-fucose catabolic process (GO:0042355)2.63232963
170* DNA replication (GO:0006260)2.62396123
171kinetochore organization (GO:0051383)2.62235412
172transcription elongation from RNA polymerase III promoter (GO:0006385)2.61647356
173termination of RNA polymerase III transcription (GO:0006386)2.61647356
174water-soluble vitamin biosynthetic process (GO:0042364)2.58189396
175tRNA metabolic process (GO:0006399)2.58051832
176double-strand break repair (GO:0006302)2.57566970
177base-excision repair (GO:0006284)2.57408654
178cellular component biogenesis (GO:0044085)2.57295051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18515730
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.19560133
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.19560133
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.19560133
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.18941972
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.83221424
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57465299
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.25014413
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.15772047
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75818224
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73385409
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.71775186
13ZNF274_21170338_ChIP-Seq_K562_Hela2.68103207
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44029616
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34691310
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34575609
17MYC_18940864_ChIP-ChIP_HL60_Human2.31019227
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30847930
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.26720474
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26240330
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22582775
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03586219
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.02382187
24VDR_22108803_ChIP-Seq_LS180_Human2.00839961
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99455318
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99056830
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.89882575
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87705954
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87062655
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.85970032
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85109389
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.84973258
33EWS_26573619_Chip-Seq_HEK293_Human1.78546263
34TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77264986
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76265893
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75557281
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.74809967
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72423428
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69253806
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68127637
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67458196
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65215730
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.64394741
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.63261105
45NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61879859
46MYC_22102868_ChIP-Seq_BL_Human1.61177602
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.58159554
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57646590
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56823762
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54767143
51XRN2_22483619_ChIP-Seq_HELA_Human1.54269818
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52505091
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51960786
54FUS_26573619_Chip-Seq_HEK293_Human1.51888379
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50855932
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46393534
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46246468
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.45700327
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45532192
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.45528680
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42549361
62AR_21909140_ChIP-Seq_LNCAP_Human1.40632734
63IGF1R_20145208_ChIP-Seq_DFB_Human1.38755604
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38596589
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36777899
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33478751
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33458845
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.30833733
69* VDR_23849224_ChIP-Seq_CD4+_Human1.30445511
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29534472
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.27527408
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25146406
73* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24670093
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24632982
75GABP_19822575_ChIP-Seq_HepG2_Human1.24231939
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23229969
77TTF2_22483619_ChIP-Seq_HELA_Human1.23033144
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21380901
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18704848
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16383684
81POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14508848
82CIITA_25753668_ChIP-Seq_RAJI_Human1.14282378
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13851465
84TP53_22573176_ChIP-Seq_HFKS_Human1.13377744
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13195814
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13068230
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11872721
88DCP1A_22483619_ChIP-Seq_HELA_Human1.11732480
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10546489
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09183044
91KDM5A_27292631_Chip-Seq_BREAST_Human1.08723543
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08662991
93NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08482726
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07198641
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06790042
96* IRF1_19129219_ChIP-ChIP_H3396_Human1.06630882
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05770413
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05071753
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04447337
100SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01227496
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.01120884
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00254828
103NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99047538
104SCL_19346495_ChIP-Seq_HPC-7_Human0.98790690
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98614672
106TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98520980
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97424102
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.96813018
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94851511
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94843703
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93621129
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.93551602
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93297560
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93061149
115E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92223777
116ELK1_19687146_ChIP-ChIP_HELA_Human0.91263600
117CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91187840
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91181835
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90556044
120SOX2_16153702_ChIP-ChIP_HESCs_Human0.88506285
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86461462
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84827855
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83868848
124TFEB_21752829_ChIP-Seq_HELA_Human0.83368472
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81903663
126HOXB7_26014856_ChIP-Seq_BT474_Human0.80857853
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80187553
128NCOR1_26117541_ChIP-Seq_K562_Human0.79969924
129* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78301107
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78267370
131PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77958616
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77881885
133* FOXA1_25329375_ChIP-Seq_VCAP_Human0.77828463
134* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77828463
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77095173
136ER_23166858_ChIP-Seq_MCF-7_Human0.76895599
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75319229
138ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73579529
139* AR_20517297_ChIP-Seq_VCAP_Human0.73508766
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72995284
141NCOR_22424771_ChIP-Seq_293T_Human0.70372275
142ERA_21632823_ChIP-Seq_H3396_Human0.69801938
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69668694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.29856242
2MP0004957_abnormal_blastocyst_morpholog3.80869609
3MP0006292_abnormal_olfactory_placode3.77087560
4MP0003011_delayed_dark_adaptation3.44352479
5MP0004264_abnormal_extraembryonic_tissu3.36109518
6MP0003890_abnormal_embryonic-extraembry3.09938630
7MP0002254_reproductive_system_inflammat3.01143103
8MP0010094_abnormal_chromosome_stability2.98701638
9MP0005075_abnormal_melanosome_morpholog2.97543666
10MP0008877_abnormal_DNA_methylation2.82777676
11MP0003077_abnormal_cell_cycle2.81530337
12MP0003111_abnormal_nucleus_morphology2.78387094
13MP0003693_abnormal_embryo_hatching2.68212728
14MP0010352_gastrointestinal_tract_polyps2.45956924
15MP0005499_abnormal_olfactory_system2.41509480
16MP0005394_taste/olfaction_phenotype2.41509480
17MP0002396_abnormal_hematopoietic_system2.23110544
18MP0003121_genomic_imprinting2.22869777
19MP0003718_maternal_effect2.10575663
20MP0003123_paternal_imprinting2.10253341
21MP0002938_white_spotting2.04788250
22MP0001672_abnormal_embryogenesis/_devel2.00875630
23MP0005380_embryogenesis_phenotype2.00875630
24MP0000350_abnormal_cell_proliferation1.99232056
25MP0003122_maternal_imprinting1.98209211
26MP0003646_muscle_fatigue1.96544820
27MP0008007_abnormal_cellular_replicative1.92561451
28MP0008058_abnormal_DNA_repair1.90484838
29MP0004147_increased_porphyrin_level1.87955790
30MP0003984_embryonic_growth_retardation1.83672882
31MP0002102_abnormal_ear_morphology1.83344485
32MP0002088_abnormal_embryonic_growth/wei1.83077950
33MP0006035_abnormal_mitochondrial_morpho1.81998815
34MP0006072_abnormal_retinal_apoptosis1.80689271
35MP0002160_abnormal_reproductive_system1.79927097
36MP0010030_abnormal_orbit_morphology1.77429667
37MP0008932_abnormal_embryonic_tissue1.75092011
38MP0002332_abnormal_exercise_endurance1.74799984
39MP0001293_anophthalmia1.70947035
40MP0000678_abnormal_parathyroid_gland1.70934809
41MP0002234_abnormal_pharynx_morphology1.70337353
42MP0000490_abnormal_crypts_of1.69320334
43MP0002638_abnormal_pupillary_reflex1.68955455
44MP0005257_abnormal_intraocular_pressure1.67442328
45MP0000372_irregular_coat_pigmentation1.66885882
46MP0004858_abnormal_nervous_system1.66343658
47MP0003136_yellow_coat_color1.65624768
48MP0003705_abnormal_hypodermis_morpholog1.65456803
49MP0002653_abnormal_ependyma_morphology1.63065119
50MP0002163_abnormal_gland_morphology1.57122983
51MP0001730_embryonic_growth_arrest1.54137101
52MP0002086_abnormal_extraembryonic_tissu1.47224256
53MP0002085_abnormal_embryonic_tissue1.47182987
54MP0009697_abnormal_copulation1.44690982
55MP0003938_abnormal_ear_development1.43483605
56MP0005551_abnormal_eye_electrophysiolog1.39557764
57MP0002210_abnormal_sex_determination1.36095951
58MP0002277_abnormal_respiratory_mucosa1.35690844
59MP0000313_abnormal_cell_death1.35446263
60MP0005389_reproductive_system_phenotype1.34281009
61MP0002084_abnormal_developmental_patter1.29670672
62MP0008872_abnormal_physiological_respon1.28043224
63MP0001697_abnormal_embryo_size1.27989974
64MP0005253_abnormal_eye_physiology1.27590194
65MP0002092_abnormal_eye_morphology1.25490714
66MP0008995_early_reproductive_senescence1.25386464
67MP0000049_abnormal_middle_ear1.24922543
68MP0001849_ear_inflammation1.24895283
69MP0005645_abnormal_hypothalamus_physiol1.24096412
70MP0003786_premature_aging1.23830318
71MP0004145_abnormal_muscle_electrophysio1.23577732
72MP0001929_abnormal_gametogenesis1.23514564
73MP0003315_abnormal_perineum_morphology1.23167412
74MP0000631_abnormal_neuroendocrine_gland1.22317740
75MP0004197_abnormal_fetal_growth/weight/1.21122851
76MP0001529_abnormal_vocalization1.20938861
77MP0002932_abnormal_joint_morphology1.20722651
78MP0002080_prenatal_lethality1.20658239
79MP0002127_abnormal_cardiovascular_syste1.20138519
80MP0002132_abnormal_respiratory_system1.19242091
81MP0005646_abnormal_pituitary_gland1.19025482
82MP0005083_abnormal_biliary_tract1.17729534
83MP0002837_dystrophic_cardiac_calcinosis1.16197007
84MP0008789_abnormal_olfactory_epithelium1.14931466
85MP0005266_abnormal_metabolism1.11889889
86MP0004133_heterotaxia1.11648615
87MP0006036_abnormal_mitochondrial_physio1.10408066
88MP0003195_calcinosis1.09499318
89MP0005379_endocrine/exocrine_gland_phen1.08896113
90MP0001919_abnormal_reproductive_system1.08634103
91MP0002736_abnormal_nociception_after1.07256543
92MP0000427_abnormal_hair_cycle1.05994495
93MP0003806_abnormal_nucleotide_metabolis1.05582877
94MP0004043_abnormal_pH_regulation1.04778641
95MP0000653_abnormal_sex_gland1.04777569
96MP0001968_abnormal_touch/_nociception1.04512571
97MP0002019_abnormal_tumor_incidence1.03758141
98MP0003119_abnormal_digestive_system1.02273476
99MP0003698_abnormal_male_reproductive1.02107752
100MP0002114_abnormal_axial_skeleton0.95013798
101MP0009046_muscle_twitch0.94697648
102MP0006082_CNS_inflammation0.93766915
103MP0005084_abnormal_gallbladder_morpholo0.91669095
104MP0002095_abnormal_skin_pigmentation0.90864008
105MP0000432_abnormal_head_morphology0.90749274
106MP0004142_abnormal_muscle_tone0.90393988
107MP0002233_abnormal_nose_morphology0.89766982
108MP0003183_abnormal_peptide_metabolism0.89174976
109MP0005174_abnormal_tail_pigmentation0.88987013
110MP0000762_abnormal_tongue_morphology0.88888998
111MP0000428_abnormal_craniofacial_morphol0.88678880
112MP0001764_abnormal_homeostasis0.87590581
113MP0001346_abnormal_lacrimal_gland0.84563564
114MP0005187_abnormal_penis_morphology0.84043503
115MP0001986_abnormal_taste_sensitivity0.82995332
116MP0008770_decreased_survivor_rate0.82462813
117MP0005171_absent_coat_pigmentation0.82408416
118MP0001119_abnormal_female_reproductive0.81997573
119MP0003935_abnormal_craniofacial_develop0.81951017
120MP0002722_abnormal_immune_system0.81652313
121MP0001661_extended_life_span0.80725571
122MP0008961_abnormal_basal_metabolism0.80246991
123MP0000358_abnormal_cell_content/0.79478028
124MP0000689_abnormal_spleen_morphology0.78875650
125MP0002970_abnormal_white_adipose0.78595333
126MP0004808_abnormal_hematopoietic_stem0.78317570
127MP0005023_abnormal_wound_healing0.78176877
128MP0003943_abnormal_hepatobiliary_system0.78014205
129MP0001348_abnormal_lacrimal_gland0.76924555
130MP0002876_abnormal_thyroid_physiology0.76392265
131MP0004381_abnormal_hair_follicle0.76350390
132MP0005410_abnormal_fertilization0.75815881
133MP0000858_altered_metastatic_potential0.74765576
134MP0005195_abnormal_posterior_eye0.74359781
135MP0003787_abnormal_imprinting0.73810335
136MP0001286_abnormal_eye_development0.73528706
137MP0003755_abnormal_palate_morphology0.73340664
138MP0002249_abnormal_larynx_morphology0.73088782
139MP0000566_synostosis0.72755439
140MP0008875_abnormal_xenobiotic_pharmacok0.72280396
141MP0002925_abnormal_cardiovascular_devel0.72078166
142MP0005384_cellular_phenotype0.71224975
143MP0001145_abnormal_male_reproductive0.70997053
144MP0005391_vision/eye_phenotype0.70795240
145MP0000703_abnormal_thymus_morphology0.70313784
146MP0003567_abnormal_fetal_cardiomyocyte0.70099134
147MP0002928_abnormal_bile_duct0.69226579
148MP0000647_abnormal_sebaceous_gland0.69138681
149MP0010307_abnormal_tumor_latency0.69067543
150MP0002751_abnormal_autonomic_nervous0.68595492
151MP0003186_abnormal_redox_activity0.67915053
152MP0002111_abnormal_tail_morphology0.67835415
153MP0002398_abnormal_bone_marrow0.67701566
154MP0009703_decreased_birth_body0.67543205
155MP0009333_abnormal_splenocyte_physiolog0.66624142
156MP0002429_abnormal_blood_cell0.64017688
157MP0003937_abnormal_limbs/digits/tail_de0.63104646
158MP0002075_abnormal_coat/hair_pigmentati0.62991012
159MP0003448_altered_tumor_morphology0.61124302
160MP0002116_abnormal_craniofacial_bone0.60965817

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.18175775
2Hypochromic microcytic anemia (HP:0004840)5.10158672
3Multiple enchondromatosis (HP:0005701)4.90387297
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.75274680
5Ependymoma (HP:0002888)4.47661000
6Chromsome breakage (HP:0040012)4.34216417
7Hepatoblastoma (HP:0002884)4.27806781
8Rib fusion (HP:0000902)4.18350232
9Rhabdomyosarcoma (HP:0002859)3.81230337
10Nephroblastoma (Wilms tumor) (HP:0002667)3.79110493
11Abnormality of the lower motor neuron (HP:0002366)3.68854645
12Neoplasm of striated muscle (HP:0009728)3.64668044
13Embryonal renal neoplasm (HP:0011794)3.51141910
14Meckel diverticulum (HP:0002245)3.35478413
15Abnormal lung lobation (HP:0002101)3.29238483
16Abnormality of the ileum (HP:0001549)3.20405477
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.14624245
18Pancreatic cysts (HP:0001737)3.09921401
19Rectal fistula (HP:0100590)3.07770649
20Rectovaginal fistula (HP:0000143)3.07770649
21Trismus (HP:0000211)3.04542523
22Reduced antithrombin III activity (HP:0001976)3.04405437
23Astrocytoma (HP:0009592)3.04198426
24Abnormality of the astrocytes (HP:0100707)3.04198426
25Patellar aplasia (HP:0006443)2.98447446
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93676463
27Abnormality of alanine metabolism (HP:0010916)2.93676463
28Hyperalaninemia (HP:0003348)2.93676463
29Abnormality of midbrain morphology (HP:0002418)2.92411493
30Molar tooth sign on MRI (HP:0002419)2.92411493
31Aplasia/Hypoplasia of the patella (HP:0006498)2.89450445
32Hypoplasia of the fovea (HP:0007750)2.88300142
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.88300142
34Type II lissencephaly (HP:0007260)2.83400385
35Pancreatic fibrosis (HP:0100732)2.81772367
36Fused cervical vertebrae (HP:0002949)2.80872423
37Impulsivity (HP:0100710)2.78099069
38Intestinal fistula (HP:0100819)2.76833000
39Testicular atrophy (HP:0000029)2.75986191
40Partial duplication of thumb phalanx (HP:0009944)2.75958705
41Supernumerary spleens (HP:0009799)2.74693855
42Aplasia/hypoplasia of the humerus (HP:0006507)2.71564995
43Acute necrotizing encephalopathy (HP:0006965)2.70778645
44Reticulocytopenia (HP:0001896)2.68251064
45Medulloblastoma (HP:0002885)2.67980657
46Aplastic anemia (HP:0001915)2.67442831
47Ragged-red muscle fibers (HP:0003200)2.67221518
48Small intestinal stenosis (HP:0012848)2.65385635
49Duodenal stenosis (HP:0100867)2.65385635
50Increased CSF lactate (HP:0002490)2.64909166
51Abnormality of the salivary glands (HP:0010286)2.63400024
52Absent thumb (HP:0009777)2.63319559
53Microretrognathia (HP:0000308)2.62162244
54Vaginal fistula (HP:0004320)2.62034957
55Abnormality of the preputium (HP:0100587)2.57186585
56Bifid tongue (HP:0010297)2.56462135
57Preauricular skin tag (HP:0000384)2.55897780
58Hypoplasia of the pons (HP:0012110)2.54356271
59Short humerus (HP:0005792)2.53482774
60Hypochromic anemia (HP:0001931)2.52912218
61Acute encephalopathy (HP:0006846)2.52904233
62Abnormal mitochondria in muscle tissue (HP:0008316)2.51752867
63Colon cancer (HP:0003003)2.48160649
64Congenital stationary night blindness (HP:0007642)2.47092022
65Glioma (HP:0009733)2.46674787
66Selective tooth agenesis (HP:0001592)2.45714558
67Abnormality of the pons (HP:0007361)2.44588358
68True hermaphroditism (HP:0010459)2.44393121
69Mitochondrial inheritance (HP:0001427)2.43769637
70Abnormality of the carotid arteries (HP:0005344)2.43740845
71Partial duplication of the phalanx of hand (HP:0009999)2.43626708
72Abnormal number of erythroid precursors (HP:0012131)2.43539528
73Type I transferrin isoform profile (HP:0003642)2.42908027
74Nephronophthisis (HP:0000090)2.41601490
75Myelodysplasia (HP:0002863)2.40201568
76Ectopic kidney (HP:0000086)2.39342756
77Amyotrophic lateral sclerosis (HP:0007354)2.39284643
78Pendular nystagmus (HP:0012043)2.34635578
79Abnormality of chromosome stability (HP:0003220)2.33324287
80Progressive muscle weakness (HP:0003323)2.30615797
81Glossoptosis (HP:0000162)2.29675253
82Microvesicular hepatic steatosis (HP:0001414)2.27368844
83Duplicated collecting system (HP:0000081)2.27161173
84Increased serum lactate (HP:0002151)2.27092426
85Skin tags (HP:0010609)2.26727951
86Aplasia/Hypoplasia of the sternum (HP:0006714)2.26706518
87Abnormality of the renal cortex (HP:0011035)2.25521383
88Abnormality of cells of the erythroid lineage (HP:0012130)2.23482302
89Abnormal cartilage morphology (HP:0002763)2.23172706
90Clubbing of toes (HP:0100760)2.22363793
91Abnormality of the renal collecting system (HP:0004742)2.22086663
92Anomalous pulmonary venous return (HP:0010772)2.21753612
93Sclerocornea (HP:0000647)2.21306039
94Atresia of the external auditory canal (HP:0000413)2.20882905
95Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20680922
96Shawl scrotum (HP:0000049)2.20259790
97Short thumb (HP:0009778)2.19019795
98Horizontal nystagmus (HP:0000666)2.18858858
99Abnormality of the duodenum (HP:0002246)2.18327810
100Short 5th finger (HP:0009237)2.16719033
101Birth length less than 3rd percentile (HP:0003561)2.16545940
102Renal duplication (HP:0000075)2.15357019
1033-Methylglutaconic aciduria (HP:0003535)2.14721811
104Tongue fasciculations (HP:0001308)2.14584064
105Premature ovarian failure (HP:0008209)2.14551176
106Abnormality of DNA repair (HP:0003254)2.14414738
107Progressive macrocephaly (HP:0004481)2.14088304
108Lipid accumulation in hepatocytes (HP:0006561)2.13733134
109Sloping forehead (HP:0000340)2.13687567
110Hepatocellular necrosis (HP:0001404)2.13041025
111Hepatic necrosis (HP:0002605)2.12548312
112Abnormality of the labia minora (HP:0012880)2.12140914
113Facial cleft (HP:0002006)2.09984636
114Bone marrow hypocellularity (HP:0005528)2.09652600
115Atrophy/Degeneration involving motor neurons (HP:0007373)2.09353668
116Abnormality of chromosome segregation (HP:0002916)2.08852537
117Absent radius (HP:0003974)2.08749807
118Abnormality of the phalanges of the hallux (HP:0010057)2.08003636
119Abnormality of the fovea (HP:0000493)2.07406183
120Cerebellar dysplasia (HP:0007033)2.07312300
121Large earlobe (HP:0009748)2.06002249
122Lissencephaly (HP:0001339)2.05825224
123Concave nail (HP:0001598)2.03947688
124Absent forearm bone (HP:0003953)2.03626963
125Aplasia involving forearm bones (HP:0009822)2.03626963
126Missing ribs (HP:0000921)2.00826485
127Increased hepatocellular lipid droplets (HP:0006565)2.00341368
128Renal cortical cysts (HP:0000803)1.99590771
129Attenuation of retinal blood vessels (HP:0007843)1.98023111
130Combined immunodeficiency (HP:0005387)1.97230003
131Duplication of thumb phalanx (HP:0009942)1.95918514
132Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94363754
133Abnormality of the renal medulla (HP:0100957)1.93327260
134Nasolacrimal duct obstruction (HP:0000579)1.92817693
135Tracheoesophageal fistula (HP:0002575)1.92308017
136Periauricular skin pits (HP:0100277)1.91952801
137Preauricular pit (HP:0004467)1.91952801
138Malignant neoplasm of the central nervous system (HP:0100836)1.91488863
139Horseshoe kidney (HP:0000085)1.90786106
140Breast hypoplasia (HP:0003187)1.90319196
141Cleft eyelid (HP:0000625)1.89923723
142Embryonal neoplasm (HP:0002898)1.89413983
143Abnormality of the pulmonary veins (HP:0011718)1.88791387
144Triphalangeal thumb (HP:0001199)1.88713112
145Lactic acidosis (HP:0003128)1.88379083
146Sparse eyelashes (HP:0000653)1.88358605
147Hyperinsulinemic hypoglycemia (HP:0000825)1.86455694
148Methylmalonic acidemia (HP:0002912)1.86223210
149Muscle fibrillation (HP:0010546)1.85824300
150Retinal dysplasia (HP:0007973)1.85689087
151Anencephaly (HP:0002323)1.85323790
152Abnormal number of incisors (HP:0011064)1.83487877
153Aplasia/Hypoplasia of the macula (HP:0008059)1.82993381
154Abnormality of cochlea (HP:0000375)1.82968890
155Preaxial hand polydactyly (HP:0001177)1.82109033
156Cerebral edema (HP:0002181)1.81668041
157Partial agenesis of the corpus callosum (HP:0001338)1.81654605
158Small hand (HP:0200055)1.81022754
159Abnormal protein N-linked glycosylation (HP:0012347)1.80390821
160Abnormal protein glycosylation (HP:0012346)1.80390821
161Abnormal glycosylation (HP:0012345)1.80390821
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80390821
163Neoplasm of the oral cavity (HP:0100649)1.80023344
164Methylmalonic aciduria (HP:0012120)1.79902494
165Upper motor neuron abnormality (HP:0002127)1.79715504
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.79619409
167Abnormality of small intestinal villus morphology (HP:0011472)1.79284562
168Volvulus (HP:0002580)1.77735840
169Neoplasm of the adrenal cortex (HP:0100641)1.76885834
170Hyperglycinemia (HP:0002154)1.73501419
171Optic disc pallor (HP:0000543)1.72651326
172Congenital, generalized hypertrichosis (HP:0004540)1.72194880
173Tubular atrophy (HP:0000092)1.71941840
174Squamous cell carcinoma (HP:0002860)1.70660720
175Dandy-Walker malformation (HP:0001305)1.70177790
176Chronic hepatic failure (HP:0100626)1.69431101
177Homocystinuria (HP:0002156)1.69030514
178Abnormality of homocysteine metabolism (HP:0010919)1.69030514
179Pancytopenia (HP:0001876)1.67364849
180Inability to walk (HP:0002540)1.65891983
181Severe muscular hypotonia (HP:0006829)1.63460668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.67747066
2GRK53.91086750
3ERN13.70321297
4GRK63.52998188
5FRK3.33002383
6VRK23.18043027
7TTK3.14653191
8CDC72.68062262
9CSF1R2.67152347
10BMPR1B2.62691416
11ADRBK22.56270291
12GRK12.54236590
13NUAK12.40254777
14WEE12.39891415
15STK102.39161340
16CDK72.24546331
17TGFBR22.21869435
18MATK2.12887996
19BUB12.01805243
20WNK42.01479243
21MAPK71.85880518
22PLK11.81942197
23GRK71.81898312
24TYRO31.79700058
25NME11.75496506
26CHEK21.68696571
27MAP4K21.65922166
28NEK21.62728410
29PAK41.62101351
30MOS1.56611068
31TAF11.45835074
32EPHA21.43340914
33WNK31.37616625
34BCKDK1.35376478
35SRPK11.31264116
36INSRR1.28114975
37PRKG21.24832451
38MAP3K101.16807524
39CHEK11.16109460
40WNK11.14453517
41RPS6KB21.13525234
42NEK11.09475328
43CAMK41.09077358
44AURKB1.06120356
45PNCK1.05522607
46EIF2AK11.05221904
47PINK11.03071851
48EIF2AK21.01886856
49MAPK131.00562993
50BRSK20.99079032
51DYRK30.96833680
52STK390.96314337
53TRIM280.95670477
54ACVR1B0.94158519
55ATR0.92768354
56PBK0.91592656
57MAPKAPK50.91252180
58OXSR10.91166877
59HIPK20.88457848
60CSNK1G30.88351228
61CDK40.87752960
62AURKA0.86787274
63RPS6KA50.86684898
64MAP3K40.84660314
65NME20.82871318
66TGFBR10.82509392
67AKT30.80984163
68VRK10.79929132
69CSNK1G10.79558515
70TESK20.78206146
71AKT20.76705315
72CSNK1A1L0.76044902
73MAP2K60.75806210
74CDK20.74270755
75ADRBK10.72991180
76ALK0.69935878
77MARK20.69809228
78MST40.69586565
79ATM0.67693291
80CAMK1D0.66250295
81PHKG10.64760168
82PHKG20.64760168
83STK30.63923222
84FGFR30.62767672
85BRSK10.62052281
86CDK80.60532754
87PLK40.60145403
88MKNK10.59991931
89PASK0.59914592
90CSNK1G20.59746828
91MAP3K80.57057141
92TLK10.55848984
93STK40.55296105
94PRKCI0.54585305
95PAK10.51519705
96EIF2AK30.49936338
97PLK20.49604757
98CSK0.48614614
99TAOK30.47641273
100CAMK1G0.46668185
101PIM10.46399347
102MUSK0.45212853
103MAPKAPK30.44981495
104IKBKB0.44743521
105NTRK10.44705119
106MTOR0.44185427
107MELK0.43284732
108FLT30.43246028
109CDK30.42718844
110PRKCG0.42069036
111KDR0.41272745
112* CDK10.40892100
113TIE10.40054471
114TSSK60.39466435
115MAP2K70.39355606
116DAPK10.37216871
117LATS20.37028189
118CAMKK20.37023785
119TAOK20.36293126
120BRD40.36067921
121PRKDC0.35816073
122CLK10.34555933
123STK38L0.34334742
124CSNK1D0.34327046
125CCNB10.33876833
126PIM20.33631266
127TXK0.33498234
128KIT0.33216175
129ZAK0.32770197
130MAP2K40.32680539
131DYRK20.31214897
132YES10.30463361
133CSNK2A10.29722710
134SCYL20.29372886
135EEF2K0.29343360
136RPS6KA40.28854885
137CSNK1E0.28617523
138PLK30.28540724
139ITK0.27219275
140MAPK120.26195851
141PRKCD0.26131029
142MKNK20.23312135
143CSNK2A20.23197682
144ERBB20.21621200
145BLK0.21372828
146MAPK10.20465307
147STK160.19799433
148MAP4K10.19388010

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63420897
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.41119681
3Mismatch repair_Homo sapiens_hsa034303.77948733
4Vitamin B6 metabolism_Homo sapiens_hsa007503.60951221
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.16866113
6Ribosome_Homo sapiens_hsa030102.82966550
7Homologous recombination_Homo sapiens_hsa034402.78232050
8RNA transport_Homo sapiens_hsa030132.77777301
9Base excision repair_Homo sapiens_hsa034102.66110873
10Spliceosome_Homo sapiens_hsa030402.53555425
11Fanconi anemia pathway_Homo sapiens_hsa034602.49712843
12Cell cycle_Homo sapiens_hsa041102.47807879
13One carbon pool by folate_Homo sapiens_hsa006702.44516682
14Fructose and mannose metabolism_Homo sapiens_hsa000512.27180670
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21813666
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18796388
17RNA polymerase_Homo sapiens_hsa030202.17194892
18Nucleotide excision repair_Homo sapiens_hsa034202.09709444
19Oxidative phosphorylation_Homo sapiens_hsa001902.06918356
20Pyrimidine metabolism_Homo sapiens_hsa002401.83366813
21Parkinsons disease_Homo sapiens_hsa050121.82803566
22RNA degradation_Homo sapiens_hsa030181.78102094
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73390527
24mRNA surveillance pathway_Homo sapiens_hsa030151.73389015
25Galactose metabolism_Homo sapiens_hsa000521.67818523
26Protein export_Homo sapiens_hsa030601.64566188
27Arachidonic acid metabolism_Homo sapiens_hsa005901.60372667
28Non-homologous end-joining_Homo sapiens_hsa034501.58305248
29Proteasome_Homo sapiens_hsa030501.55527228
30p53 signaling pathway_Homo sapiens_hsa041151.53023967
31Huntingtons disease_Homo sapiens_hsa050161.43243728
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43002386
33Basal transcription factors_Homo sapiens_hsa030221.38154162
34Phototransduction_Homo sapiens_hsa047441.37934063
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32045887
36Thyroid cancer_Homo sapiens_hsa052161.30319568
37Nitrogen metabolism_Homo sapiens_hsa009101.17100499
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.16510546
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12233633
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11248301
41Butanoate metabolism_Homo sapiens_hsa006501.09373347
42Linoleic acid metabolism_Homo sapiens_hsa005911.08300457
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06257819
44Herpes simplex infection_Homo sapiens_hsa051681.03404846
45Propanoate metabolism_Homo sapiens_hsa006401.01961071
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00942759
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99431973
48Alzheimers disease_Homo sapiens_hsa050100.98229671
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96674532
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95832470
51Folate biosynthesis_Homo sapiens_hsa007900.95224486
52Pentose phosphate pathway_Homo sapiens_hsa000300.92880549
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91575240
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89120362
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88168259
56Tryptophan metabolism_Homo sapiens_hsa003800.85263918
57Pyruvate metabolism_Homo sapiens_hsa006200.84145596
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83235134
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80025800
60Cardiac muscle contraction_Homo sapiens_hsa042600.78954912
61Purine metabolism_Homo sapiens_hsa002300.78133543
62Caffeine metabolism_Homo sapiens_hsa002320.77418574
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76183220
64Lysine degradation_Homo sapiens_hsa003100.75351159
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74951269
66MicroRNAs in cancer_Homo sapiens_hsa052060.72020916
67mTOR signaling pathway_Homo sapiens_hsa041500.71586817
68Sulfur relay system_Homo sapiens_hsa041220.71368479
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71360719
70Viral carcinogenesis_Homo sapiens_hsa052030.69917278
71Other glycan degradation_Homo sapiens_hsa005110.69659211
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68123081
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66880460
74Basal cell carcinoma_Homo sapiens_hsa052170.65050280
75Peroxisome_Homo sapiens_hsa041460.64422273
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63991555
77HTLV-I infection_Homo sapiens_hsa051660.62722733
78Biosynthesis of amino acids_Homo sapiens_hsa012300.61129143
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60300701
80Primary immunodeficiency_Homo sapiens_hsa053400.58863400
81Systemic lupus erythematosus_Homo sapiens_hsa053220.56286823
82Acute myeloid leukemia_Homo sapiens_hsa052210.55984376
83Epstein-Barr virus infection_Homo sapiens_hsa051690.54588155
84Olfactory transduction_Homo sapiens_hsa047400.54504839
85Apoptosis_Homo sapiens_hsa042100.54244798
86Pathways in cancer_Homo sapiens_hsa052000.53527033
87Selenocompound metabolism_Homo sapiens_hsa004500.53221402
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50637271
89Steroid biosynthesis_Homo sapiens_hsa001000.50210685
90Antigen processing and presentation_Homo sapiens_hsa046120.49823807
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.48050737
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.48009047
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.46899496
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.46759554
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46664239
96Fatty acid elongation_Homo sapiens_hsa000620.46654241
97Small cell lung cancer_Homo sapiens_hsa052220.45536144
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.44409476
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44189955
100Bladder cancer_Homo sapiens_hsa052190.43332176
101Notch signaling pathway_Homo sapiens_hsa043300.41295348
102Nicotine addiction_Homo sapiens_hsa050330.40355510
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39376121
104Legionellosis_Homo sapiens_hsa051340.39354947
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38724740
106Arginine and proline metabolism_Homo sapiens_hsa003300.38202498
107Carbon metabolism_Homo sapiens_hsa012000.38198301
108Oocyte meiosis_Homo sapiens_hsa041140.38145495
109Hedgehog signaling pathway_Homo sapiens_hsa043400.37923502
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.37712152
111Hippo signaling pathway_Homo sapiens_hsa043900.37699140
112Taste transduction_Homo sapiens_hsa047420.36928198
113Sulfur metabolism_Homo sapiens_hsa009200.33876162
114Fatty acid metabolism_Homo sapiens_hsa012120.33697230
115N-Glycan biosynthesis_Homo sapiens_hsa005100.33666711
116Alcoholism_Homo sapiens_hsa050340.33664676
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33512009
118Non-small cell lung cancer_Homo sapiens_hsa052230.33433950
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31984926
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.30691061
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28830776
122Colorectal cancer_Homo sapiens_hsa052100.27878425
123Influenza A_Homo sapiens_hsa051640.27106374
124Vitamin digestion and absorption_Homo sapiens_hsa049770.26541514
125Inositol phosphate metabolism_Homo sapiens_hsa005620.26459880
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.25850569
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25488295
128Regulation of autophagy_Homo sapiens_hsa041400.25294809
129Hematopoietic cell lineage_Homo sapiens_hsa046400.25238089
130Glutathione metabolism_Homo sapiens_hsa004800.24732157
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24241987
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24184580
133Chemical carcinogenesis_Homo sapiens_hsa052040.24166161
134ABC transporters_Homo sapiens_hsa020100.20641169
135Metabolic pathways_Homo sapiens_hsa011000.19876345
136beta-Alanine metabolism_Homo sapiens_hsa004100.19846587
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19434138
138Measles_Homo sapiens_hsa051620.18355424
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.18056908
140Wnt signaling pathway_Homo sapiens_hsa043100.17880225
141Retinol metabolism_Homo sapiens_hsa008300.17428167
142Ether lipid metabolism_Homo sapiens_hsa005650.16445393
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15308431
144Renin-angiotensin system_Homo sapiens_hsa046140.15167764
145Ovarian steroidogenesis_Homo sapiens_hsa049130.14459165
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.14203839
147Pancreatic cancer_Homo sapiens_hsa052120.14197975
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14003703
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13912077
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13642879

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