CHAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with autosomal dominant mental retardation-40. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.81414583
2DNA topological change (GO:0006265)4.64664734
3* protein localization to kinetochore (GO:0034501)4.43203916
4nuclear pore organization (GO:0006999)4.33181513
5regulation of RNA export from nucleus (GO:0046831)4.22461776
6mitotic nuclear envelope disassembly (GO:0007077)4.21797863
7nuclear pore complex assembly (GO:0051292)4.21072583
8DNA replication initiation (GO:0006270)4.14742459
9mitotic metaphase plate congression (GO:0007080)4.05086748
10nucleosome disassembly (GO:0006337)4.02179824
11protein-DNA complex disassembly (GO:0032986)4.02179824
12IMP biosynthetic process (GO:0006188)4.01751248
13membrane disassembly (GO:0030397)3.97815829
14nuclear envelope disassembly (GO:0051081)3.97815829
15nucleobase biosynthetic process (GO:0046112)3.92171764
16glucocorticoid receptor signaling pathway (GO:0042921)3.85265003
17DNA strand elongation involved in DNA replication (GO:0006271)3.83622967
18IMP metabolic process (GO:0046040)3.82618960
19DNA strand elongation (GO:0022616)3.76210912
20DNA replication checkpoint (GO:0000076)3.75664446
21DNA replication-dependent nucleosome assembly (GO:0006335)3.68666860
22DNA replication-dependent nucleosome organization (GO:0034723)3.68666860
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68236969
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68236969
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.68236969
26negative regulation of microtubule polymerization (GO:0031115)3.66010897
27formation of translation preinitiation complex (GO:0001731)3.64761037
28microtubule depolymerization (GO:0007019)3.63081422
29regulation of DNA methylation (GO:0044030)3.53336826
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51955217
31ribosome assembly (GO:0042255)3.51933055
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50306573
33mitotic sister chromatid segregation (GO:0000070)3.50036690
34metaphase plate congression (GO:0051310)3.49895828
35positive regulation of gene expression, epigenetic (GO:0045815)3.48945474
36purine nucleobase biosynthetic process (GO:0009113)3.48339351
37* protein localization to chromosome, centromeric region (GO:0071459)3.48199488
38folic acid-containing compound biosynthetic process (GO:0009396)3.48005899
39pre-miRNA processing (GO:0031054)3.47418696
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47415043
41DNA synthesis involved in DNA repair (GO:0000731)3.47196528
42mitotic chromosome condensation (GO:0007076)3.43946298
43histone H2A monoubiquitination (GO:0035518)3.42188617
44negative regulation of histone methylation (GO:0031061)3.40704821
45DNA duplex unwinding (GO:0032508)3.40362177
46ribosome biogenesis (GO:0042254)3.40003592
47regulation of spindle organization (GO:0090224)3.39262201
48DNA geometric change (GO:0032392)3.38840642
49mRNA stabilization (GO:0048255)3.38782538
50RNA stabilization (GO:0043489)3.38782538
51response to histamine (GO:0034776)3.37760036
52peptidyl-arginine omega-N-methylation (GO:0035247)3.37175157
53sister chromatid segregation (GO:0000819)3.35754674
54regulation of chromatin binding (GO:0035561)3.35332012
55mitotic sister chromatid cohesion (GO:0007064)3.33265865
56DNA replication-independent nucleosome organization (GO:0034724)3.31048409
57DNA replication-independent nucleosome assembly (GO:0006336)3.31048409
58regulation of NFAT protein import into nucleus (GO:0051532)3.28616890
59maturation of SSU-rRNA (GO:0030490)3.23203128
60mRNA splice site selection (GO:0006376)3.23074612
61CENP-A containing nucleosome assembly (GO:0034080)3.21658736
62kinetochore organization (GO:0051383)3.20922675
63positive regulation of RNA splicing (GO:0033120)3.20650810
64chromatin remodeling at centromere (GO:0031055)3.20411690
65regulation of sister chromatid cohesion (GO:0007063)3.19408545
66negative regulation of RNA splicing (GO:0033119)3.19373392
67* attachment of spindle microtubules to kinetochore (GO:0008608)3.17938892
68chromosome condensation (GO:0030261)3.17547261
69maturation of 5.8S rRNA (GO:0000460)3.16923447
70negative regulation of chromosome segregation (GO:0051985)3.16770798
71positive regulation of chromosome segregation (GO:0051984)3.16751379
72telomere maintenance via semi-conservative replication (GO:0032201)3.16191984
73regulation of nucleobase-containing compound transport (GO:0032239)3.14973430
74mitotic spindle assembly checkpoint (GO:0007094)3.12987026
75nuclear envelope organization (GO:0006998)3.12468631
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.12326182
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12326182
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12326182
79negative regulation of sister chromatid segregation (GO:0033046)3.12326182
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11773675
81histone H2A acetylation (GO:0043968)3.11575430
82spindle assembly checkpoint (GO:0071173)3.11345065
83* protein localization to chromosome (GO:0034502)3.10878404
84peptidyl-arginine methylation (GO:0018216)3.10801892
85peptidyl-arginine N-methylation (GO:0035246)3.10801892
86chromatin assembly (GO:0031497)3.10579206
87alternative mRNA splicing, via spliceosome (GO:0000380)3.10476415
88histone arginine methylation (GO:0034969)3.09429535
89RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.09424539
90mRNA splicing, via spliceosome (GO:0000398)3.09424539
91RNA splicing, via transesterification reactions (GO:0000375)3.08557191
92regulation of chromosome segregation (GO:0051983)3.08508518
93pore complex assembly (GO:0046931)3.08481702
94heterochromatin organization (GO:0070828)3.08453104
95spindle checkpoint (GO:0031577)3.08114816
96telomere maintenance via telomerase (GO:0007004)3.08058231
97establishment of chromosome localization (GO:0051303)3.06857334
98telomere maintenance via telomere lengthening (GO:0010833)3.03927913
99mitotic spindle checkpoint (GO:0071174)3.03710862
100spliceosomal tri-snRNP complex assembly (GO:0000244)3.02895189
101ectodermal placode formation (GO:0060788)3.00562023
102negative regulation of fibroblast apoptotic process (GO:2000270)3.00340354
103chromatin assembly or disassembly (GO:0006333)2.99455061
104regulation of translational termination (GO:0006449)2.98546857
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98061338
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97958602
107striatum development (GO:0021756)2.95021252
108histone exchange (GO:0043486)2.94900935
109dosage compensation (GO:0007549)2.94510079
110spliceosomal snRNP assembly (GO:0000387)2.94049286
111negative regulation of mRNA processing (GO:0050686)2.93515242
112kinetochore assembly (GO:0051382)2.93472437
113regulation of histone H3-K9 methylation (GO:0051570)2.93185772
114regulation of synapse structural plasticity (GO:0051823)2.92635490
115ATP-dependent chromatin remodeling (GO:0043044)2.92592763
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92494885
117regulation of sister chromatid segregation (GO:0033045)2.91182648
118regulation of mitotic sister chromatid separation (GO:0010965)2.91182648
119regulation of mitotic sister chromatid segregation (GO:0033047)2.91182648
120mitotic recombination (GO:0006312)2.91130081
121telomere maintenance via recombination (GO:0000722)2.91101565
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.89497364
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89497364
124ribonucleoprotein complex biogenesis (GO:0022613)2.88953366
125regulation of histone H3-K4 methylation (GO:0051569)2.88689049
126regulation of chromatin silencing (GO:0031935)2.88556769
127pyrimidine nucleobase catabolic process (GO:0006208)2.87658551
128regulation of mitotic spindle organization (GO:0060236)2.87644448
129DNA conformation change (GO:0071103)2.85951332
130prepulse inhibition (GO:0060134)2.85405818
131mRNA transport (GO:0051028)2.84605038
132negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83626451
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83626451
134regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82441861
135cell migration in hindbrain (GO:0021535)2.80466783
136pyrimidine dimer repair (GO:0006290)2.80297415
137regulation of histone methylation (GO:0031060)2.75562802
138corticosteroid receptor signaling pathway (GO:0031958)2.74705937
139regulation of translational fidelity (GO:0006450)2.74429975
140regulation of growth hormone secretion (GO:0060123)2.71363577
141negative regulation of mRNA metabolic process (GO:1903312)2.70803572
142histone H3-K9 methylation (GO:0051567)2.70631475
143positive regulation by host of viral transcription (GO:0043923)2.65800751
144positive regulation of DNA-dependent DNA replication (GO:2000105)2.63338657
145intracellular estrogen receptor signaling pathway (GO:0030520)2.61854276
146negative regulation of circadian rhythm (GO:0042754)2.61777393
147convergent extension (GO:0060026)2.61429677
148DNA packaging (GO:0006323)2.58521687
149regulation of mRNA stability (GO:0043488)2.57768226
150chromosome segregation (GO:0007059)2.55710757
151negative regulation of osteoblast proliferation (GO:0033689)2.54358348
152dopamine biosynthetic process (GO:0042416)2.53425583
153meiotic chromosome segregation (GO:0045132)2.51676625
154planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51598433
155tetrahydrofolate metabolic process (GO:0046653)2.51151355
156establishment of mitotic spindle localization (GO:0040001)2.50701093
157regulation of RNA stability (GO:0043487)2.50090142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.50135555
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51380626
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.41256214
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80308034
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26073613
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24450264
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08530002
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80073602
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67681004
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.62461827
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54937883
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52753240
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.45140760
14XRN2_22483619_ChIP-Seq_HELA_Human2.40217582
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36724491
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35055594
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.32359156
18AR_21909140_ChIP-Seq_LNCAP_Human2.30856353
19EZH2_22144423_ChIP-Seq_EOC_Human2.29280157
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.28951608
21MYC_22102868_ChIP-Seq_BL_Human2.27451892
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25878616
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.14231164
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09913505
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09309792
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.07717623
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.05771817
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05760315
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02900278
30CIITA_25753668_ChIP-Seq_RAJI_Human1.97737861
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95416236
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94666711
33TTF2_22483619_ChIP-Seq_HELA_Human1.94013140
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91082402
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90601056
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.88243291
37VDR_23849224_ChIP-Seq_CD4+_Human1.82201844
38GABP_19822575_ChIP-Seq_HepG2_Human1.77605787
39FOXP3_21729870_ChIP-Seq_TREG_Human1.77460336
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72972778
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71646647
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68421695
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68149340
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64869886
45DCP1A_22483619_ChIP-Seq_HELA_Human1.60510065
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54874961
47KDM5A_27292631_Chip-Seq_BREAST_Human1.54693769
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53279548
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53123790
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52572340
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52437830
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48903283
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44095716
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39205414
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37351209
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36161496
57ELK1_19687146_ChIP-ChIP_HELA_Human1.34823753
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34370446
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33872605
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32987758
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30949580
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30621238
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30190691
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29287987
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27775175
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27066450
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25856161
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25558779
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.25025661
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24772078
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24275356
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24219484
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23646781
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22861089
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22585239
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22097976
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21169649
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.20828969
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20537133
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18093360
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13659324
82REST_19997604_ChIP-ChIP_NEURONS_Mouse1.13319394
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11838894
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10988905
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10641798
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09694596
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09563894
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08748431
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08717367
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07344223
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06780672
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04617702
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03554108
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.03471974
95TFEB_21752829_ChIP-Seq_HELA_Human1.02475544
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01680935
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01617242
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00663059
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.00417959
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98533070
101GATA1_26923725_Chip-Seq_HPCs_Mouse0.97988818
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97978230
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97978230
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97978230
105TCF7_22412390_ChIP-Seq_EML_Mouse0.97977031
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97282571
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96824180
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96441172
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96083550
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95405067
111VDR_21846776_ChIP-Seq_THP-1_Human0.95146306
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94201205
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.92849785
114MYC_18940864_ChIP-ChIP_HL60_Human0.92564613
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.92416485
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91893688
117KDM2B_26808549_Chip-Seq_DND41_Human0.90506015
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.89375886
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89119922
120ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88749486
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88144408
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87338594
123E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86845042
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86747722
125TP53_22127205_ChIP-Seq_IMR90_Human0.84188688
126CHD1_26751641_Chip-Seq_LNCaP_Human0.83147626
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82736384
128POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81716314
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80614373
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.80110040
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79717540
132POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79062835
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78977044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.12081019
2MP0003111_abnormal_nucleus_morphology4.05784314
3MP0003693_abnormal_embryo_hatching4.04963783
4MP0004957_abnormal_blastocyst_morpholog3.78180205
5MP0003123_paternal_imprinting3.62727701
6MP0003077_abnormal_cell_cycle3.46901448
7MP0008057_abnormal_DNA_replication3.07186400
8MP0002822_catalepsy2.84511622
9MP0001529_abnormal_vocalization2.71769892
10MP0003121_genomic_imprinting2.69557828
11MP0008058_abnormal_DNA_repair2.66031647
12MP0005409_darkened_coat_color2.53726027
13MP0008877_abnormal_DNA_methylation2.52480979
14MP0008007_abnormal_cellular_replicative2.40139356
15MP0008932_abnormal_embryonic_tissue2.38738944
16MP0001730_embryonic_growth_arrest2.29626603
17MP0000350_abnormal_cell_proliferation2.29364697
18MP0001188_hyperpigmentation2.26023457
19MP0010352_gastrointestinal_tract_polyps2.25537863
20MP0010030_abnormal_orbit_morphology2.01417984
21MP0002396_abnormal_hematopoietic_system2.00594664
22MP0002084_abnormal_developmental_patter1.87366391
23MP0003890_abnormal_embryonic-extraembry1.84903048
24MP0002085_abnormal_embryonic_tissue1.84120026
25MP0001697_abnormal_embryo_size1.81651920
26MP0005380_embryogenesis_phenotype1.80111447
27MP0001672_abnormal_embryogenesis/_devel1.80111447
28MP0005076_abnormal_cell_differentiation1.77125876
29MP0004233_abnormal_muscle_weight1.75772626
30MP0000537_abnormal_urethra_morphology1.74893186
31MP0010307_abnormal_tumor_latency1.71467214
32MP0004197_abnormal_fetal_growth/weight/1.63832072
33MP0004859_abnormal_synaptic_plasticity1.61851632
34MP0003984_embryonic_growth_retardation1.59109762
35MP0000778_abnormal_nervous_system1.59046579
36MP0002080_prenatal_lethality1.57266950
37MP0003119_abnormal_digestive_system1.56954803
38MP0004808_abnormal_hematopoietic_stem1.56625597
39MP0002088_abnormal_embryonic_growth/wei1.54965479
40MP0006292_abnormal_olfactory_placode1.53719378
41MP0002697_abnormal_eye_size1.52812829
42MP0005257_abnormal_intraocular_pressure1.52034884
43MP0000490_abnormal_crypts_of1.50196064
44MP0002009_preneoplasia1.44953983
45MP0008789_abnormal_olfactory_epithelium1.42809535
46MP0003786_premature_aging1.42320986
47MP0002086_abnormal_extraembryonic_tissu1.41245595
48MP0002163_abnormal_gland_morphology1.34876838
49MP0003567_abnormal_fetal_cardiomyocyte1.34707094
50MP0003315_abnormal_perineum_morphology1.33057389
51MP0003122_maternal_imprinting1.30567886
52MP0002653_abnormal_ependyma_morphology1.30220621
53MP0005499_abnormal_olfactory_system1.27896406
54MP0005394_taste/olfaction_phenotype1.27896406
55MP0003787_abnormal_imprinting1.25490994
56MP0003718_maternal_effect1.25459709
57MP0002210_abnormal_sex_determination1.23557342
58MP0000313_abnormal_cell_death1.23128535
59MP0001293_anophthalmia1.22833603
60MP0005423_abnormal_somatic_nervous1.20635909
61MP0003937_abnormal_limbs/digits/tail_de1.17381985
62MP0001849_ear_inflammation1.16211876
63MP0003861_abnormal_nervous_system1.15161185
64MP0001346_abnormal_lacrimal_gland1.10923179
65MP0009672_abnormal_birth_weight1.05737513
66MP0001145_abnormal_male_reproductive1.04459917
67MP0002019_abnormal_tumor_incidence1.04265901
68MP0006072_abnormal_retinal_apoptosis1.02473376
69MP0002152_abnormal_brain_morphology1.01354819
70MP0000428_abnormal_craniofacial_morphol0.99990732
71MP0000653_abnormal_sex_gland0.99541270
72MP0003705_abnormal_hypodermis_morpholog0.99061645
73MP0004133_heterotaxia0.98201263
74MP0002102_abnormal_ear_morphology0.97563996
75MP0003115_abnormal_respiratory_system0.97349731
76MP0000703_abnormal_thymus_morphology0.97079343
77MP0001929_abnormal_gametogenesis0.96868336
78MP0003283_abnormal_digestive_organ0.96499290
79MP0003942_abnormal_urinary_system0.93249817
80MP0000003_abnormal_adipose_tissue0.92681617
81MP0000049_abnormal_middle_ear0.90824539
82MP0000015_abnormal_ear_pigmentation0.90804941
83MP0001119_abnormal_female_reproductive0.90351804
84MP0004185_abnormal_adipocyte_glucose0.90258005
85MP0000631_abnormal_neuroendocrine_gland0.89254712
86MP0009703_decreased_birth_body0.88679347
87MP0000733_abnormal_muscle_development0.88537571
88MP0005384_cellular_phenotype0.88466630
89MP0000569_abnormal_digit_pigmentation0.87032237
90MP0005623_abnormal_meninges_morphology0.86092669
91MP0000955_abnormal_spinal_cord0.85884551
92MP0002177_abnormal_outer_ear0.84971124
93MP0005621_abnormal_cell_physiology0.84417441
94MP0003755_abnormal_palate_morphology0.84041430
95MP0004811_abnormal_neuron_physiology0.84005752
96MP0002877_abnormal_melanocyte_morpholog0.83866512
97MP0002111_abnormal_tail_morphology0.83836086
98MP0003935_abnormal_craniofacial_develop0.83286753
99MP0002932_abnormal_joint_morphology0.83249540
100MP0001286_abnormal_eye_development0.82825759
101MP0004742_abnormal_vestibular_system0.81907224
102MP0008438_abnormal_cutaneous_collagen0.78665920
103MP0003221_abnormal_cardiomyocyte_apopto0.78161840
104MP0009250_abnormal_appendicular_skeleto0.77754016
105MP0002081_perinatal_lethality0.77352987
106MP0002114_abnormal_axial_skeleton0.76970060
107MP0001915_intracranial_hemorrhage0.76926984
108MP0001943_abnormal_respiration0.76774397
109MP0003385_abnormal_body_wall0.76357785
110MP0001348_abnormal_lacrimal_gland0.75882404
111MP0000432_abnormal_head_morphology0.75017792
112MP0005367_renal/urinary_system_phenotyp0.74996449
113MP0000516_abnormal_urinary_system0.74996449
114MP0002092_abnormal_eye_morphology0.74375998
115MP0002089_abnormal_postnatal_growth/wei0.74364444
116MP0002116_abnormal_craniofacial_bone0.74287212
117MP0000534_abnormal_ureter_morphology0.73676382
118MP0002751_abnormal_autonomic_nervous0.70473640
119MP0005187_abnormal_penis_morphology0.70044330
120MP0009053_abnormal_anal_canal0.68514560
121MP0000358_abnormal_cell_content/0.66532692
122MP0002233_abnormal_nose_morphology0.65829132
123MP0003699_abnormal_female_reproductive0.63573973
124MP0009333_abnormal_splenocyte_physiolog0.62513985
125MP0002160_abnormal_reproductive_system0.62178636
126MP0002398_abnormal_bone_marrow0.61780237

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.12188380
2Poikiloderma (HP:0001029)3.82000684
3Ependymoma (HP:0002888)3.81791812
4Colon cancer (HP:0003003)3.72039984
5Abnormality of the labia minora (HP:0012880)3.53672725
6Cortical dysplasia (HP:0002539)3.46966515
7Overriding aorta (HP:0002623)3.45821637
8Medulloblastoma (HP:0002885)3.37978363
9Patellar aplasia (HP:0006443)3.17331045
10Abnormality of the astrocytes (HP:0100707)3.12032822
11Astrocytoma (HP:0009592)3.12032822
12Breast hypoplasia (HP:0003187)3.02393833
13Selective tooth agenesis (HP:0001592)3.01257221
14Aplasia/Hypoplasia of the patella (HP:0006498)2.96943148
15Degeneration of anterior horn cells (HP:0002398)2.81582116
16Abnormality of the anterior horn cell (HP:0006802)2.81582116
17Abnormality of the phalanges of the hallux (HP:0010057)2.67471496
18Entropion (HP:0000621)2.66413785
19Abnormal number of incisors (HP:0011064)2.65019644
20Short 4th metacarpal (HP:0010044)2.63726051
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63726051
22Increased nuchal translucency (HP:0010880)2.63666454
23Heterotopia (HP:0002282)2.61449301
24Glioma (HP:0009733)2.55602248
25Insomnia (HP:0100785)2.55310112
26Proximal placement of thumb (HP:0009623)2.55274596
27Deviation of the thumb (HP:0009603)2.55222819
28Volvulus (HP:0002580)2.52729433
29Partial agenesis of the corpus callosum (HP:0001338)2.51771946
30Shoulder girdle muscle weakness (HP:0003547)2.43782482
31Long palpebral fissure (HP:0000637)2.42893249
32Rough bone trabeculation (HP:0100670)2.40959067
33Rhabdomyosarcoma (HP:0002859)2.40797740
34Pelvic girdle muscle weakness (HP:0003749)2.40316251
35Elfin facies (HP:0004428)2.40126234
36Deep palmar crease (HP:0006191)2.39148280
37Basal cell carcinoma (HP:0002671)2.36389928
38Obsessive-compulsive behavior (HP:0000722)2.34561228
39Cerebral hypomyelination (HP:0006808)2.33922428
40Facial hemangioma (HP:0000329)2.32000227
41Chromsome breakage (HP:0040012)2.31904528
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31392082
43Agnosia (HP:0010524)2.30723360
44Neoplasm of the oral cavity (HP:0100649)2.28895608
45Impulsivity (HP:0100710)2.27117216
46Atrophy/Degeneration involving motor neurons (HP:0007373)2.25287550
47Renovascular hypertension (HP:0100817)2.24877633
48Atresia of the external auditory canal (HP:0000413)2.24189103
49Neoplasm of striated muscle (HP:0009728)2.22534837
50Embryonal renal neoplasm (HP:0011794)2.21907768
51Carpal bone hypoplasia (HP:0001498)2.18458469
52Overlapping toe (HP:0001845)2.15665946
53Hepatoblastoma (HP:0002884)2.14267108
54Spina bifida occulta (HP:0003298)2.13742517
55Abnormality of the septum pellucidum (HP:0007375)2.09292697
56Freckling (HP:0001480)2.09248026
57Pseudobulbar signs (HP:0002200)2.05603099
58Renal duplication (HP:0000075)2.05151069
59Disproportionate tall stature (HP:0001519)2.04771982
60Diastasis recti (HP:0001540)2.03876280
61Myelodysplasia (HP:0002863)2.02221924
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.01979691
63Cutaneous melanoma (HP:0012056)2.01308810
64Abnormality of chromosome segregation (HP:0002916)2.01308609
65Shawl scrotum (HP:0000049)2.01262882
66Abnormality of DNA repair (HP:0003254)2.01088323
67Arnold-Chiari malformation (HP:0002308)2.00892203
68Meckel diverticulum (HP:0002245)2.00714094
69Morphological abnormality of the middle ear (HP:0008609)1.98501135
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.97208746
71Abnormality of the musculature of the pelvis (HP:0001469)1.97167585
72Abnormality of the hip-girdle musculature (HP:0001445)1.97167585
73Abnormality of chromosome stability (HP:0003220)1.96978746
74Abnormality of the ileum (HP:0001549)1.94883395
75Neoplasm of the pancreas (HP:0002894)1.94700629
76Hypoplasia of the brainstem (HP:0002365)1.94177069
77Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94177069
78Supernumerary spleens (HP:0009799)1.93915827
79Bifid tongue (HP:0010297)1.93735850
80Oral leukoplakia (HP:0002745)1.92710736
81Abnormality of the fingertips (HP:0001211)1.91913442
82Flat cornea (HP:0007720)1.91736039
83Aplastic anemia (HP:0001915)1.91634390
84Abnormality of the lower motor neuron (HP:0002366)1.91495970
85Spinal muscular atrophy (HP:0007269)1.91475694
86Acute lymphatic leukemia (HP:0006721)1.89976842
87Abnormality of the preputium (HP:0100587)1.89697929
88High anterior hairline (HP:0009890)1.89361047
89Absent radius (HP:0003974)1.88776516
90Broad thumb (HP:0011304)1.87668122
91Papillary thyroid carcinoma (HP:0002895)1.86946087
92Missing ribs (HP:0000921)1.85670144
93Sacral dimple (HP:0000960)1.85022443
94Absent septum pellucidum (HP:0001331)1.84617876
95Skull defect (HP:0001362)1.84358184
96Duodenal stenosis (HP:0100867)1.83384603
97Small intestinal stenosis (HP:0012848)1.83384603
98Abnormality of the intervertebral disk (HP:0005108)1.80994658
99Absent forearm bone (HP:0003953)1.80784797
100Aplasia involving forearm bones (HP:0009822)1.80784797
101Squamous cell carcinoma (HP:0002860)1.80511694
102Abnormality of cochlea (HP:0000375)1.80026009
103Abnormality of the 4th metacarpal (HP:0010012)1.79444982
104Preauricular skin tag (HP:0000384)1.78894538
105Glossoptosis (HP:0000162)1.78726982
106Tracheoesophageal fistula (HP:0002575)1.77199200
107Hyperacusis (HP:0010780)1.76985251
108Reticulocytopenia (HP:0001896)1.75936373
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.74211793
110Skin tags (HP:0010609)1.74138635
111Bowel diverticulosis (HP:0005222)1.73749872
112Horseshoe kidney (HP:0000085)1.73180401
113Shallow orbits (HP:0000586)1.72939996
114Spinal cord lesions (HP:0100561)1.72551768
115Syringomyelia (HP:0003396)1.72551768
116Genu recurvatum (HP:0002816)1.71902556
117Septate vagina (HP:0001153)1.71638291
118Midline defect of the nose (HP:0004122)1.71418932
119Abnormality of the carotid arteries (HP:0005344)1.71112058
120Ectopic kidney (HP:0000086)1.71021277
12111 pairs of ribs (HP:0000878)1.70880863
122Abnormality of the calcaneus (HP:0008364)1.70743225
123Limb dystonia (HP:0002451)1.70628867
124Short thumb (HP:0009778)1.68934818
125Embryonal neoplasm (HP:0002898)1.68677306
126Trismus (HP:0000211)1.68649700
127Genetic anticipation (HP:0003743)1.68511001
128Cafe-au-lait spot (HP:0000957)1.68219315
129Congenital diaphragmatic hernia (HP:0000776)1.68044756
130Pointed chin (HP:0000307)1.67888734
131Nephroblastoma (Wilms tumor) (HP:0002667)1.67721949
132Abnormal trabecular bone morphology (HP:0100671)1.67371948
133Abnormal tarsal ossification (HP:0008369)1.67306005
134Slender long bone (HP:0003100)1.67094916
135Premature ovarian failure (HP:0008209)1.66785931
136Patellar dislocation (HP:0002999)1.65960291
137Bladder diverticulum (HP:0000015)1.65744461
138Megalocornea (HP:0000485)1.65666788
139Broad palm (HP:0001169)1.64363901
140Lissencephaly (HP:0001339)1.63993948
141Radioulnar synostosis (HP:0002974)1.63852956
142Long eyelashes (HP:0000527)1.63686077
143Abnormality of abdominal situs (HP:0011620)1.63587309
144Abdominal situs inversus (HP:0003363)1.63587309
145Sloping forehead (HP:0000340)1.63037964
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62635609
147Retinal dysplasia (HP:0007973)1.61813867
148Gastrointestinal carcinoma (HP:0002672)1.61718553
149Malignant gastrointestinal tract tumors (HP:0006749)1.61718553
150Prominent nose (HP:0000448)1.61702292
151Sandal gap (HP:0001852)1.61682804
152Omphalocele (HP:0001539)1.61414946
153Short 1st metacarpal (HP:0010034)1.61234108
154Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61234108
155Broad phalanges of the hand (HP:0009768)1.60996052
156Progressive external ophthalmoplegia (HP:0000590)1.60556783
157Abnormality of the incisor (HP:0000676)1.60235109
158Urethral obstruction (HP:0000796)1.60140914
159Rib fusion (HP:0000902)1.59869634
160Trigonocephaly (HP:0000243)1.59544133
161Calcaneovalgus deformity (HP:0001848)1.58867031
162Absent eyebrow (HP:0002223)1.58701527
163Bicornuate uterus (HP:0000813)1.57741124
164Neoplasm of the adrenal cortex (HP:0100641)1.55283830
165Personality changes (HP:0000751)1.54736293
166Transitional cell carcinoma of the bladder (HP:0006740)1.54519521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.82390400
2WEE13.49637615
3BUB13.25898092
4EEF2K3.21794200
5SIK13.06701370
6TSSK63.00555731
7CDK122.91504069
8ICK2.75318019
9CAMK1D2.71908045
10NEK22.60304324
11TTK2.59347470
12SMG12.53840888
13EIF2AK12.42387619
14NEK12.40988573
15SIK22.40366644
16MKNK12.34017292
17CAMK1G2.15989531
18ACVR1B2.11239720
19TAF12.06865989
20LATS22.04802697
21PASK1.98344864
22SRPK11.96513573
23PLK11.92150666
24RPS6KB21.87857612
25PLK31.80474948
26MKNK21.74106656
27ATR1.61500596
28EIF2AK21.59362864
29CDK71.56473303
30PLK41.53414578
31BRSK21.53245949
32CHEK11.52160191
33DYRK31.47111103
34CHEK21.45013100
35ALK1.44256331
36AURKB1.39028768
37PKN21.37334356
38STK101.34255491
39TYRO31.32655382
40MAP3K101.32623429
41TGFBR11.31475201
42SIK31.30439896
43CDK41.27508401
44BRSK11.25856760
45MAP3K81.22162983
46TESK21.17662891
47PRKD31.15374676
48PAK41.14579089
49MAP3K121.14472931
50PRPF4B1.13822405
51CDK21.13421499
52WNK31.09001745
53MELK1.08484585
54AURKA1.06694107
55EIF2AK31.06530082
56ATM1.01114608
57PDGFRA0.98105753
58UHMK10.97673010
59PNCK0.96101203
60DYRK20.94202005
61BRD40.92400402
62FGFR40.88271808
63CDK10.87028608
64CDK80.86961826
65WNK10.86865270
66SCYL20.85733903
67MTOR0.83982390
68MARK10.82614063
69RPS6KA40.80635632
70DYRK1A0.79285208
71VRK10.74455221
72KSR10.73658158
73DAPK10.73518085
74CSNK1E0.68574145
75MAP3K90.66870524
76PRKCI0.66129120
77EPHA20.65226748
78MAP3K40.64725057
79STK30.62324704
80CDK90.61884507
81CSNK2A20.60750180
82PAK20.60608987
83ERBB30.59686141
84RPS6KB10.58210262
85ERBB40.58041997
86LATS10.56475734
87YES10.54891523
88MAP3K60.54691363
89CAMK40.54522317
90CDK60.54247153
91CCNB10.54140207
92PRKDC0.53870986
93MARK20.53771701
94NEK90.53377188
95MOS0.51971689
96CSF1R0.51577262
97TRIM280.50649349
98CLK10.50439364
99NTRK20.49372850
100PAK10.48177924
101SGK30.47989743
102CSNK1D0.47937695
103CSNK1A1L0.47606568
104MAPK140.47353701
105FGFR10.47342573
106PIM10.47228453
107MAPK130.45289453
108TNIK0.45102231
109CDK180.43783069
110CHUK0.43416809
111CDK50.43281519
112CDK30.42939131
113STK240.42908355
114CDK190.42894936
115LIMK10.42637602
116BCR0.42354238
117BRAF0.42178975
118CDK150.41558953
119GSK3B0.40723148
120AKT20.40397764
121CDK11A0.40379230
122CDK140.40311572
123MAP3K110.39792525
124CSNK1G30.39380533
125MINK10.39299765
126BCKDK0.38474535
127CSNK2A10.38471339
128AKT10.37613529
129MAP2K40.37334053
130TRIB30.36451042
131MAPK90.36229227
132EPHB20.36160023
133MAPKAPK30.35813502
134TAOK10.35764766
135RPS6KA10.35376789
136LRRK20.34102472
137CDC42BPA0.33548249
138MAPK100.33059854
139DYRK1B0.31590545

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.02488342
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65500766
3Mismatch repair_Homo sapiens_hsa034303.59298560
4RNA transport_Homo sapiens_hsa030133.38774607
5Spliceosome_Homo sapiens_hsa030403.22121161
6Cell cycle_Homo sapiens_hsa041102.99812408
7RNA polymerase_Homo sapiens_hsa030202.59063467
8Base excision repair_Homo sapiens_hsa034102.49116291
9Nucleotide excision repair_Homo sapiens_hsa034202.35956335
10mRNA surveillance pathway_Homo sapiens_hsa030152.34396058
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33252222
12RNA degradation_Homo sapiens_hsa030182.08199491
13Homologous recombination_Homo sapiens_hsa034402.07435151
14One carbon pool by folate_Homo sapiens_hsa006701.95108473
15Fanconi anemia pathway_Homo sapiens_hsa034601.85022057
16Ribosome_Homo sapiens_hsa030101.80755660
17Basal transcription factors_Homo sapiens_hsa030221.75428189
18Selenocompound metabolism_Homo sapiens_hsa004501.68159510
19Pyrimidine metabolism_Homo sapiens_hsa002401.65018525
20Lysine degradation_Homo sapiens_hsa003101.64460185
21Oocyte meiosis_Homo sapiens_hsa041141.62634667
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.56621350
23Proteasome_Homo sapiens_hsa030501.52964544
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49613345
25p53 signaling pathway_Homo sapiens_hsa041151.42901172
26Non-homologous end-joining_Homo sapiens_hsa034501.37738937
27Colorectal cancer_Homo sapiens_hsa052101.34242357
28Epstein-Barr virus infection_Homo sapiens_hsa051691.26812795
29Nicotine addiction_Homo sapiens_hsa050331.26706661
30Cocaine addiction_Homo sapiens_hsa050301.21957805
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15674163
32MicroRNAs in cancer_Homo sapiens_hsa052061.12305340
33mTOR signaling pathway_Homo sapiens_hsa041501.11424250
34HTLV-I infection_Homo sapiens_hsa051661.07764022
35Thyroid cancer_Homo sapiens_hsa052161.06438342
36Viral carcinogenesis_Homo sapiens_hsa052031.03405831
37Hippo signaling pathway_Homo sapiens_hsa043901.02862629
38Purine metabolism_Homo sapiens_hsa002301.01142091
39B cell receptor signaling pathway_Homo sapiens_hsa046620.99849432
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94941146
41Chronic myeloid leukemia_Homo sapiens_hsa052200.93856462
42TGF-beta signaling pathway_Homo sapiens_hsa043500.93158498
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90205250
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89828753
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88761722
46Axon guidance_Homo sapiens_hsa043600.82391936
47Basal cell carcinoma_Homo sapiens_hsa052170.82312679
48Endometrial cancer_Homo sapiens_hsa052130.80488502
49Protein export_Homo sapiens_hsa030600.79729890
50Herpes simplex infection_Homo sapiens_hsa051680.77769769
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77640990
52Antigen processing and presentation_Homo sapiens_hsa046120.73427509
53Small cell lung cancer_Homo sapiens_hsa052220.72432916
54Hedgehog signaling pathway_Homo sapiens_hsa043400.72134537
55Pancreatic cancer_Homo sapiens_hsa052120.70676217
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.69690539
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.67540355
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66361938
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65629253
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64461712
61Non-small cell lung cancer_Homo sapiens_hsa052230.63810680
62Melanogenesis_Homo sapiens_hsa049160.63624314
63Wnt signaling pathway_Homo sapiens_hsa043100.62734457
64Adherens junction_Homo sapiens_hsa045200.62400719
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60843457
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57635671
67Alcoholism_Homo sapiens_hsa050340.56719183
68Serotonergic synapse_Homo sapiens_hsa047260.56592378
69Glioma_Homo sapiens_hsa052140.55572371
70Dopaminergic synapse_Homo sapiens_hsa047280.54888945
71Inositol phosphate metabolism_Homo sapiens_hsa005620.54510338
72Pathways in cancer_Homo sapiens_hsa052000.54351175
73Viral myocarditis_Homo sapiens_hsa054160.53528292
74Acute myeloid leukemia_Homo sapiens_hsa052210.53286165
75Hepatitis B_Homo sapiens_hsa051610.52693436
76Notch signaling pathway_Homo sapiens_hsa043300.51979075
77Systemic lupus erythematosus_Homo sapiens_hsa053220.51724688
78Type II diabetes mellitus_Homo sapiens_hsa049300.50806215
79Prostate cancer_Homo sapiens_hsa052150.48818278
80Amphetamine addiction_Homo sapiens_hsa050310.48804340
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48118848
82Fatty acid biosynthesis_Homo sapiens_hsa000610.47367703
83Prion diseases_Homo sapiens_hsa050200.46927189
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46623973
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.46464301
86Bladder cancer_Homo sapiens_hsa052190.45525045
87Proteoglycans in cancer_Homo sapiens_hsa052050.45283968
88Biosynthesis of amino acids_Homo sapiens_hsa012300.44929217
89Melanoma_Homo sapiens_hsa052180.44538210
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44370659
91Apoptosis_Homo sapiens_hsa042100.44142260
92HIF-1 signaling pathway_Homo sapiens_hsa040660.43822434
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43616465
94N-Glycan biosynthesis_Homo sapiens_hsa005100.42980899
95Renal cell carcinoma_Homo sapiens_hsa052110.42918242
96ErbB signaling pathway_Homo sapiens_hsa040120.42735333
97Shigellosis_Homo sapiens_hsa051310.41988459
98Gap junction_Homo sapiens_hsa045400.40888848
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40880371
100Estrogen signaling pathway_Homo sapiens_hsa049150.39503289
101Influenza A_Homo sapiens_hsa051640.38807113
102Sulfur relay system_Homo sapiens_hsa041220.38553790
103FoxO signaling pathway_Homo sapiens_hsa040680.38417294
104Circadian rhythm_Homo sapiens_hsa047100.36547965
105MAPK signaling pathway_Homo sapiens_hsa040100.35064640
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34632040
107Legionellosis_Homo sapiens_hsa051340.34254277
108VEGF signaling pathway_Homo sapiens_hsa043700.31755822
109T cell receptor signaling pathway_Homo sapiens_hsa046600.31130795
110Tight junction_Homo sapiens_hsa045300.30961098
111Insulin signaling pathway_Homo sapiens_hsa049100.29840685
112Prolactin signaling pathway_Homo sapiens_hsa049170.28994259
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.28175094
114Long-term potentiation_Homo sapiens_hsa047200.26844046
115Pentose phosphate pathway_Homo sapiens_hsa000300.26700009
116Regulation of autophagy_Homo sapiens_hsa041400.26463569
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25027607
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24864614
119Measles_Homo sapiens_hsa051620.24685255
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24026427
121AMPK signaling pathway_Homo sapiens_hsa041520.22277586
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22156380
123Choline metabolism in cancer_Homo sapiens_hsa052310.21648425

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