CHAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)9.37086415
2cell migration in hindbrain (GO:0021535)7.40563989
3sympathetic nervous system development (GO:0048485)7.29016145
4ganglion development (GO:0061548)6.16084663
5microtubule severing (GO:0051013)5.71010562
6vocalization behavior (GO:0071625)5.61795512
7synaptic transmission, cholinergic (GO:0007271)5.26076510
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25031033
9pyrimidine nucleobase catabolic process (GO:0006208)5.11020056
10neurotransmitter-gated ion channel clustering (GO:0072578)5.03446035
11dopaminergic neuron differentiation (GO:0071542)5.02138521
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00924898
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.93625788
14regulation of synapse structural plasticity (GO:0051823)4.89288795
15peristalsis (GO:0030432)4.77437067
16negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.75835998
17* neurotransmitter secretion (GO:0007269)4.74334523
18regulation of cardioblast proliferation (GO:0003264)4.58218587
19regulation of secondary heart field cardioblast proliferation (GO:0003266)4.58218587
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.58175672
21striatum development (GO:0021756)4.55638294
22regulation of glutamate receptor signaling pathway (GO:1900449)4.55562270
23adaptation of signaling pathway (GO:0023058)4.46686168
24synaptic vesicle maturation (GO:0016188)4.42178250
25nerve growth factor signaling pathway (GO:0038180)4.35031809
26locomotory exploration behavior (GO:0035641)4.31507369
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.31245259
28positive regulation of transcription regulatory region DNA binding (GO:2000679)4.30691120
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.29530463
30positive regulation of synaptic transmission, GABAergic (GO:0032230)4.29153420
31cAMP catabolic process (GO:0006198)4.26728687
32protein localization to synapse (GO:0035418)4.24061555
33neuron cell-cell adhesion (GO:0007158)4.22517307
34synaptic vesicle exocytosis (GO:0016079)4.19769188
35startle response (GO:0001964)4.17876911
36neuron-neuron synaptic transmission (GO:0007270)4.16622843
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14137184
38regulation of glycogen (starch) synthase activity (GO:2000465)4.11774951
39auditory behavior (GO:0031223)4.09417798
40regulation of synaptic transmission, glutamatergic (GO:0051966)4.06519683
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.99220949
42transmission of nerve impulse (GO:0019226)3.98245517
43response to auditory stimulus (GO:0010996)3.96092975
44neuronal action potential propagation (GO:0019227)3.95330419
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94906732
46behavioral response to ethanol (GO:0048149)3.94787459
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91941356
48glycine transport (GO:0015816)3.90448727
49regulation of neuronal synaptic plasticity (GO:0048168)3.90228382
50positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.89930684
51positive regulation of cell cycle G2/M phase transition (GO:1902751)3.89930684
52* neurotransmitter transport (GO:0006836)3.89639649
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.88110424
54activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.88017689
55regulation of glutamate secretion (GO:0014048)3.87045370
56peripheral nervous system neuron development (GO:0048935)3.85434986
57cyclic nucleotide catabolic process (GO:0009214)3.85195643
58nucleobase catabolic process (GO:0046113)3.84789446
59prepulse inhibition (GO:0060134)3.82066561
60synaptic transmission, dopaminergic (GO:0001963)3.81446603
61regulation of respiratory system process (GO:0044065)3.77752752
62glutamate receptor signaling pathway (GO:0007215)3.76999083
63regulation of synaptic vesicle exocytosis (GO:2000300)3.75843851
64regulation of NFAT protein import into nucleus (GO:0051532)3.74914460
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.73915144
66synaptic transmission, glutamatergic (GO:0035249)3.73051640
67cell migration involved in heart development (GO:0060973)3.70510036
68neuronal ion channel clustering (GO:0045161)3.66258304
69microtubule depolymerization (GO:0007019)3.62993478
70response to amphetamine (GO:0001975)3.62990031
71central nervous system neuron axonogenesis (GO:0021955)3.57252050
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.54942042
73regulation of synaptic vesicle transport (GO:1902803)3.53333648
74* regulation of neurotransmitter levels (GO:0001505)3.53085244
75regulation of mRNA catabolic process (GO:0061013)3.52911283
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50351763
77regulation of female receptivity (GO:0045924)3.47798002
78regulation of synaptic transmission, GABAergic (GO:0032228)3.47611682
79postsynaptic membrane organization (GO:0001941)3.47597479
80regulation of heart morphogenesis (GO:2000826)3.47266986
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.47010358
82regulation of respiratory gaseous exchange (GO:0043576)3.46819391
83behavioral response to cocaine (GO:0048148)3.44259669
84exploration behavior (GO:0035640)3.40641277
85positive regulation of neurotransmitter transport (GO:0051590)3.39415864
86membrane hyperpolarization (GO:0060081)3.39113458
87regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38940719
88regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.38623732
89long-term memory (GO:0007616)3.38468738
90* neuromuscular synaptic transmission (GO:0007274)3.35458861
91regulation of circadian sleep/wake cycle (GO:0042749)3.33977764
92regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.33977764
93glutamate secretion (GO:0014047)3.30024876
94long-term synaptic potentiation (GO:0060291)3.28281491
95serotonin metabolic process (GO:0042428)3.28209612
96neurofilament cytoskeleton organization (GO:0060052)3.27889301
97gamma-aminobutyric acid transport (GO:0015812)3.27601235
98regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26810000
99regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26810000
100positive regulation of fibroblast migration (GO:0010763)3.26368345
101negative regulation of dendrite development (GO:2000171)3.25854511
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25711084
103cAMP metabolic process (GO:0046058)3.25212732
104regulation of postsynaptic membrane potential (GO:0060078)3.23947436
105regulation of synaptic transmission, dopaminergic (GO:0032225)3.23778644
106synaptic vesicle endocytosis (GO:0048488)3.22627739
107presynaptic membrane assembly (GO:0097105)3.22581505
108neuromuscular process controlling balance (GO:0050885)3.21973328
109negative regulation of amino acid transport (GO:0051956)3.21786310
110adenosine receptor signaling pathway (GO:0001973)3.21669629
111regulation of dendrite morphogenesis (GO:0048814)3.21473208
112dopamine receptor signaling pathway (GO:0007212)3.21333039
113behavioral fear response (GO:0001662)3.20945361
114behavioral defense response (GO:0002209)3.20945361
115visual learning (GO:0008542)3.20235945
116mechanosensory behavior (GO:0007638)3.20203951
117presynaptic membrane organization (GO:0097090)3.20168999
118female mating behavior (GO:0060180)3.19987561
119definitive hemopoiesis (GO:0060216)3.19846230
120synapse assembly (GO:0007416)3.19787163
121negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.19467987
122regulation of dendritic spine morphogenesis (GO:0061001)3.18358272
123response to nicotine (GO:0035094)3.18223818
124urinary tract smooth muscle contraction (GO:0014848)3.17524258
125positive regulation of membrane potential (GO:0045838)3.17500901
126negative regulation of dendrite morphogenesis (GO:0050774)3.16365505
127response to histamine (GO:0034776)3.13802478
128membrane depolarization during action potential (GO:0086010)3.13247908
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11785606
130* adult walking behavior (GO:0007628)3.10330927
131negative regulation of cell cycle arrest (GO:0071157)3.10173356
132type B pancreatic cell development (GO:0003323)3.10161137
133nuclear pore complex assembly (GO:0051292)3.09122967
134activation of adenylate cyclase activity (GO:0007190)3.08863567
135positive regulation of synaptic transmission (GO:0050806)3.08773306
136cardiac ventricle formation (GO:0003211)3.08424689
137lens morphogenesis in camera-type eye (GO:0002089)3.08345483
138regulation of voltage-gated calcium channel activity (GO:1901385)3.04028755
139visual behavior (GO:0007632)3.03977097
140neuromuscular process (GO:0050905)3.03939146
141coronary vasculature morphogenesis (GO:0060977)3.03793023
142learning (GO:0007612)3.02812785
143dorsal/ventral neural tube patterning (GO:0021904)3.02742499
144peptidyl-lysine dimethylation (GO:0018027)2.99357932
145cranial nerve development (GO:0021545)2.98927332
146response to nerve growth factor (GO:1990089)2.90668745
147cellular response to nerve growth factor stimulus (GO:1990090)2.90668745
148pancreas development (GO:0031016)2.87613502
149outer ear morphogenesis (GO:0042473)2.86965201
150cardiac chamber formation (GO:0003207)2.85506585
151nuclear pore organization (GO:0006999)2.83102181
152cartilage morphogenesis (GO:0060536)2.82332539
153establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.82298645
154mitochondrion transport along microtubule (GO:0047497)2.82298645
155positive regulation of adenylate cyclase activity (GO:0045762)2.81192820
156negative regulation of DNA repair (GO:0045738)2.80833016
157neuron migration (GO:0001764)2.79694302
158spermatid nucleus differentiation (GO:0007289)2.79284508
159negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78521848
160negative regulation of mRNA metabolic process (GO:1903312)2.78358777
161regulation of retinoic acid receptor signaling pathway (GO:0048385)2.76212982
162central nervous system projection neuron axonogenesis (GO:0021952)2.76005843
163histone H3-K9 modification (GO:0061647)2.75445400
164detection of temperature stimulus (GO:0016048)2.73611349
165spinal cord motor neuron differentiation (GO:0021522)2.69904187
166regulation of histone H3-K9 methylation (GO:0051570)2.69000987
167substrate-independent telencephalic tangential migration (GO:0021826)2.67732851
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67732851
169lung epithelium development (GO:0060428)2.66951718
170positive regulation of oligodendrocyte differentiation (GO:0048714)2.66156245
171establishment of mitochondrion localization (GO:0051654)2.63009091
172tongue development (GO:0043586)2.62602370
173axonogenesis (GO:0007409)2.58964271
174mesenchymal cell proliferation (GO:0010463)2.58580328
175acrosome reaction (GO:0007340)2.58298750
176phasic smooth muscle contraction (GO:0014821)2.58183212
177cranial nerve morphogenesis (GO:0021602)2.57231471
178viral mRNA export from host cell nucleus (GO:0046784)2.56148871
179negative regulation of astrocyte differentiation (GO:0048712)2.54310497
180microtubule polymerization or depolymerization (GO:0031109)2.53244281
181protein polyglutamylation (GO:0018095)2.52682368
182negative regulation of glycogen biosynthetic process (GO:0045719)2.51988428
183forebrain development (GO:0030900)2.50676149
184rRNA modification (GO:0000154)2.49353946
185neural crest cell migration (GO:0001755)2.47046751
186negative regulation of catecholamine secretion (GO:0033604)2.45079011
187centrosome duplication (GO:0051298)2.43488038
188rRNA methylation (GO:0031167)2.42480099
189intestinal epithelial cell development (GO:0060576)2.41451386
190negative regulation of glial cell differentiation (GO:0045686)2.39807660
191regulation of centriole replication (GO:0046599)2.39646995
192cell differentiation in hindbrain (GO:0021533)2.39641333
193mechanoreceptor differentiation (GO:0042490)2.39538632
194behavioral response to nicotine (GO:0035095)10.1254691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.62677429
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.32732479
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.24720994
4EZH2_22144423_ChIP-Seq_EOC_Human5.04149704
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.83359347
6GBX2_23144817_ChIP-Seq_PC3_Human3.70633743
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17460639
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05776157
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86276219
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74845875
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74845875
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74028135
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.71455295
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.67932646
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67522979
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60878034
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53102953
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50999771
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.42605838
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.42552200
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.41977461
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40205798
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39147801
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38184829
25REST_21632747_ChIP-Seq_MESCs_Mouse2.36543960
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33193134
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.21384024
28TAF15_26573619_Chip-Seq_HEK293_Human2.15796075
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.13484094
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11408872
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09153457
32FUS_26573619_Chip-Seq_HEK293_Human2.08192040
33DROSHA_22980978_ChIP-Seq_HELA_Human2.07931976
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06128101
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87475573
36AR_21572438_ChIP-Seq_LNCaP_Human1.86222940
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84100741
38* REST_18959480_ChIP-ChIP_MESCs_Mouse1.81329555
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.78968278
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76132440
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76028383
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74283117
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.67916869
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.67703999
45SMAD4_21799915_ChIP-Seq_A2780_Human1.65970235
46RNF2_27304074_Chip-Seq_NSC_Mouse1.64821705
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61930052
48SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.60211435
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56748161
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51742418
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50307816
52P300_19829295_ChIP-Seq_ESCs_Human1.50247667
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.42661258
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41472160
55IGF1R_20145208_ChIP-Seq_DFB_Human1.39406104
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39183686
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38973236
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.37943117
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37523271
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.37084278
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.35973727
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35786203
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34783216
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31453080
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26315820
66AR_25329375_ChIP-Seq_VCAP_Human1.25476199
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24754245
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24754245
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24696099
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24484397
71IRF1_19129219_ChIP-ChIP_H3396_Human1.24392254
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22072286
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.21429860
74EWS_26573619_Chip-Seq_HEK293_Human1.20683033
75STAT3_23295773_ChIP-Seq_U87_Human1.19373519
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.18896783
77RUNX2_22187159_ChIP-Seq_PCA_Human1.16298647
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13908658
79* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13044897
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11571922
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10716925
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09761251
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09213932
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.07955925
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07170759
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.07022776
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.06327278
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05870725
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04423617
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03998501
91TCF4_23295773_ChIP-Seq_U87_Human1.02554136
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00935180
93* AR_19668381_ChIP-Seq_PC3_Human1.00843967
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00729619
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.00522577
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.00291910
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99974632
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99317077
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98741832
100E2F7_22180533_ChIP-Seq_HELA_Human0.97775547
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97610605
102AHR_22903824_ChIP-Seq_MCF-7_Human0.97353715
103P53_22387025_ChIP-Seq_ESCs_Mouse0.96940130
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96492133
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96280046
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95644875
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95158942
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94148390
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94008354
110TP53_18474530_ChIP-ChIP_U2OS_Human0.93788040
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93431870
112JUN_21703547_ChIP-Seq_K562_Human0.93330917
113ER_23166858_ChIP-Seq_MCF-7_Human0.92889358
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92838948
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.92492441
116SOX9_26525672_Chip-Seq_HEART_Mouse0.92111502
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91995690
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.91952210
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91181077
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90848434
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.90219139
122* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89884018
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89705349
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.88802012
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.87786881
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.86330923
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85629970
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85615996
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.85525010
130P300_18555785_Chip-Seq_ESCs_Mouse0.84967349
131TAL1_26923725_Chip-Seq_HPCs_Mouse0.84171158
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.83507257
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82636799
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81505983
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80650978
136CBP_20019798_ChIP-Seq_JUKART_Human0.80650978
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79587873
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.78550634
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.78243629
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76963142
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76366714
142ZNF274_21170338_ChIP-Seq_K562_Hela0.75577543
143GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75536471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.61230250
2MP0004859_abnormal_synaptic_plasticity4.70283169
3MP0003880_abnormal_central_pattern3.92817386
4MP0002751_abnormal_autonomic_nervous3.90456172
5* MP0003635_abnormal_synaptic_transmissio3.59922951
6MP0009745_abnormal_behavioral_response3.52784319
7MP0009046_muscle_twitch3.07101670
8MP0002063_abnormal_learning/memory/cond3.05067344
9MP0005083_abnormal_biliary_tract3.03349860
10MP0005646_abnormal_pituitary_gland2.97979010
11MP0002064_seizures2.97258271
12MP0003787_abnormal_imprinting2.96612075
13MP0001188_hyperpigmentation2.96209354
14MP0001486_abnormal_startle_reflex2.81435351
15MP0005423_abnormal_somatic_nervous2.70981439
16MP0002572_abnormal_emotion/affect_behav2.59118026
17MP0002272_abnormal_nervous_system2.57839962
18MP0005377_hearing/vestibular/ear_phenot2.56765852
19MP0003878_abnormal_ear_physiology2.56765852
20MP0001501_abnormal_sleep_pattern2.45232698
21MP0005187_abnormal_penis_morphology2.40382397
22MP0001529_abnormal_vocalization2.34742709
23MP0002102_abnormal_ear_morphology2.26532178
24MP0001968_abnormal_touch/_nociception2.22440948
25MP0002734_abnormal_mechanical_nocicepti2.22009344
26* MP0004142_abnormal_muscle_tone2.11427057
27* MP0002184_abnormal_innervation2.11262960
28MP0004270_analgesia2.02181648
29MP0000538_abnormal_urinary_bladder1.92262740
30MP0002557_abnormal_social/conspecific_i1.85340107
31MP0002067_abnormal_sensory_capabilities1.81052708
32MP0005645_abnormal_hypothalamus_physiol1.77929764
33MP0005386_behavior/neurological_phenoty1.76709812
34MP0004924_abnormal_behavior1.76709812
35MP0002736_abnormal_nociception_after1.70915288
36MP0002638_abnormal_pupillary_reflex1.70518342
37* MP0000955_abnormal_spinal_cord1.69566634
38MP0008569_lethality_at_weaning1.65597354
39MP0001984_abnormal_olfaction1.64044018
40MP0001970_abnormal_pain_threshold1.61731487
41MP0002735_abnormal_chemical_nociception1.58386727
42MP0005197_abnormal_uvea_morphology1.56339132
43MP0006276_abnormal_autonomic_nervous1.55620926
44MP0005394_taste/olfaction_phenotype1.49444085
45MP0005499_abnormal_olfactory_system1.49444085
46MP0005551_abnormal_eye_electrophysiolog1.46557958
47MP0001177_atelectasis1.45202882
48MP0004811_abnormal_neuron_physiology1.43423210
49MP0002909_abnormal_adrenal_gland1.43273131
50MP0002697_abnormal_eye_size1.43017907
51MP0000778_abnormal_nervous_system1.40832690
52MP0001440_abnormal_grooming_behavior1.39468463
53MP0001270_distended_abdomen1.38548578
54MP0002733_abnormal_thermal_nociception1.35115327
55* MP0002882_abnormal_neuron_morphology1.34444327
56MP0005084_abnormal_gallbladder_morpholo1.32828308
57MP0000372_irregular_coat_pigmentation1.30973552
58MP0000383_abnormal_hair_follicle1.29457221
59MP0002653_abnormal_ependyma_morphology1.28547635
60MP0000678_abnormal_parathyroid_gland1.27984312
61MP0003119_abnormal_digestive_system1.25260112
62MP0001502_abnormal_circadian_rhythm1.21623929
63* MP0002066_abnormal_motor_capabilities/c1.19460921
64MP0003879_abnormal_hair_cell1.19442703
65MP0002332_abnormal_exercise_endurance1.18757537
66MP0004885_abnormal_endolymph1.10909627
67* MP0002752_abnormal_somatic_nervous1.10302711
68MP0009780_abnormal_chondrocyte_physiolo1.08872532
69MP0005409_darkened_coat_color1.08075713
70MP0002876_abnormal_thyroid_physiology1.08063268
71MP0006292_abnormal_olfactory_placode1.06583305
72MP0003567_abnormal_fetal_cardiomyocyte1.03293225
73MP0003633_abnormal_nervous_system1.02693295
74MP0006072_abnormal_retinal_apoptosis1.01652231
75MP0005085_abnormal_gallbladder_physiolo1.01223162
76MP0002009_preneoplasia1.01121043
77MP0002090_abnormal_vision0.99682314
78MP0008874_decreased_physiological_sensi0.99437325
79MP0003195_calcinosis0.98961105
80MP0000537_abnormal_urethra_morphology0.98195364
81MP0003315_abnormal_perineum_morphology0.97914866
82MP0005171_absent_coat_pigmentation0.96397501
83MP0000049_abnormal_middle_ear0.95489899
84MP0002234_abnormal_pharynx_morphology0.94068568
85MP0005410_abnormal_fertilization0.93371190
86MP0003122_maternal_imprinting0.93218506
87MP0001905_abnormal_dopamine_level0.92367281
88MP0003937_abnormal_limbs/digits/tail_de0.92354093
89MP0010678_abnormal_skin_adnexa0.91764829
90MP0002163_abnormal_gland_morphology0.90656865
91MP0004742_abnormal_vestibular_system0.90510893
92MP0008877_abnormal_DNA_methylation0.89513831
93MP0002932_abnormal_joint_morphology0.89208633
94MP0008260_abnormal_autophagy0.88667207
95MP0002229_neurodegeneration0.88369846
96MP0003861_abnormal_nervous_system0.87854446
97MP0008789_abnormal_olfactory_epithelium0.87475581
98MP0002127_abnormal_cardiovascular_syste0.85993283
99MP0000631_abnormal_neuroendocrine_gland0.85793725
100MP0003283_abnormal_digestive_organ0.85394535
101MP0003698_abnormal_male_reproductive0.85140573
102MP0003631_nervous_system_phenotype0.84085831
103MP0004134_abnormal_chest_morphology0.82614719
104MP0005253_abnormal_eye_physiology0.82272049
105MP0010386_abnormal_urinary_bladder0.81761813
106MP0002069_abnormal_eating/drinking_beha0.80223605
107MP0002938_white_spotting0.78874785
108MP0001963_abnormal_hearing_physiology0.78715994
109MP0002152_abnormal_brain_morphology0.78059547
110MP0008995_early_reproductive_senescence0.77575783
111MP0003890_abnormal_embryonic-extraembry0.77379997
112MP0008961_abnormal_basal_metabolism0.75795237
113MP0005391_vision/eye_phenotype0.75525747
114MP0000566_synostosis0.75018498
115MP0005623_abnormal_meninges_morphology0.73644894
116MP0004133_heterotaxia0.71817102
117* MP0002081_perinatal_lethality0.71354852
118MP0003121_genomic_imprinting0.70690652
119MP0001929_abnormal_gametogenesis0.70141715
120MP0001299_abnormal_eye_distance/0.70058619
121MP0001340_abnormal_eyelid_morphology0.69485944
122MP0004858_abnormal_nervous_system0.68933436
123MP0003136_yellow_coat_color0.68791290
124MP0002277_abnormal_respiratory_mucosa0.68067397
125MP0000026_abnormal_inner_ear0.67851985
126MP0005535_abnormal_body_temperature0.67441311
127MP0001485_abnormal_pinna_reflex0.67364985
128MP0000462_abnormal_digestive_system0.66565972
129MP0003935_abnormal_craniofacial_develop0.66444551
130MP0008872_abnormal_physiological_respon0.66134552
131MP0009765_abnormal_xenobiotic_induced0.66073397
132MP0003938_abnormal_ear_development0.65915890
133MP0003075_altered_response_to0.65647841
134MP0003183_abnormal_peptide_metabolism0.65021776
135MP0003077_abnormal_cell_cycle0.64991226
136MP0001944_abnormal_pancreas_morphology0.63622401
137MP0003690_abnormal_glial_cell0.63387980
138MP0009250_abnormal_appendicular_skeleto0.62618483
139MP0004085_abnormal_heartbeat0.62245565
140MP0001664_abnormal_digestion0.62160147
141MP0003632_abnormal_nervous_system0.60961262
142MP0002249_abnormal_larynx_morphology0.60731490
143MP0001943_abnormal_respiration0.59983807
144MP0003011_delayed_dark_adaptation0.59805945

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)7.94598642
2Focal motor seizures (HP:0011153)6.99309162
3Myokymia (HP:0002411)6.81014670
4Febrile seizures (HP:0002373)5.99010284
5Focal seizures (HP:0007359)5.01950119
6Tubulointerstitial fibrosis (HP:0005576)4.50229505
7Abnormality of the phalanges of the 2nd finger (HP:0009541)4.38338524
8Breast hypoplasia (HP:0003187)4.22893590
9Atonic seizures (HP:0010819)4.22341295
10Tubulointerstitial abnormality (HP:0001969)4.21256010
11Epileptic encephalopathy (HP:0200134)4.19694742
12Abnormality of the corticospinal tract (HP:0002492)3.99324870
13Hyperventilation (HP:0002883)3.97659235
14Keratoconus (HP:0000563)3.58988048
15Increased corneal curvature (HP:0100692)3.58988048
16Generalized tonic-clonic seizures (HP:0002069)3.52538085
17Torticollis (HP:0000473)3.42268987
18Broad-based gait (HP:0002136)3.38248479
19Absence seizures (HP:0002121)3.35239848
20Congenital stationary night blindness (HP:0007642)3.34350175
21Abnormality of the vocal cords (HP:0008777)3.32365401
22Tubulointerstitial nephritis (HP:0001970)3.18665479
23Intestinal atresia (HP:0011100)3.15780708
24Ankle clonus (HP:0011448)3.12072919
25Dialeptic seizures (HP:0011146)3.10698780
26Cortical dysplasia (HP:0002539)3.09542377
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07984255
28Degeneration of the lateral corticospinal tracts (HP:0002314)3.07984255
29Hypoplastic nipples (HP:0002557)3.07969423
30Hypotrichosis (HP:0001006)3.04647895
31Abnormality of the phalanges of the hallux (HP:0010057)3.03144206
32Esophageal atresia (HP:0002032)3.03069783
33Anxiety (HP:0000739)3.01120178
34Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00031878
35Gaze-evoked nystagmus (HP:0000640)2.95293415
36Termporal pattern (HP:0011008)2.94453725
37Insidious onset (HP:0003587)2.94453725
38Supranuclear gaze palsy (HP:0000605)2.91599380
39Depression (HP:0000716)2.89370768
40Progressive cerebellar ataxia (HP:0002073)2.89307008
41Postural instability (HP:0002172)2.86569662
42Hypoventilation (HP:0002791)2.86388567
43Lower limb amyotrophy (HP:0007210)2.86318074
44Partial duplication of the phalanx of hand (HP:0009999)2.82818405
45Wide anterior fontanel (HP:0000260)2.79262668
46Abnormal eating behavior (HP:0100738)2.75885737
47Craniofacial dystonia (HP:0012179)2.74996393
48Focal dystonia (HP:0004373)2.71168780
49Resting tremor (HP:0002322)2.70406137
50Upper limb muscle weakness (HP:0003484)2.68908107
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.64245030
52Self-mutilation (HP:0000742)2.63771586
53Fetal akinesia sequence (HP:0001989)2.62134031
54Fragile nails (HP:0001808)2.60475888
55Poor eye contact (HP:0000817)2.59457188
56Chromsome breakage (HP:0040012)2.57838365
57Dysdiadochokinesis (HP:0002075)2.54135956
58Supernumerary spleens (HP:0009799)2.52612638
59Arthropathy (HP:0003040)2.51499096
60Abnormal social behavior (HP:0012433)2.51415732
61Impaired social interactions (HP:0000735)2.51415732
62Incomplete penetrance (HP:0003829)2.51100579
63Impaired vibration sensation in the lower limbs (HP:0002166)2.51002358
64Polyphagia (HP:0002591)2.50864783
65Abnormality of the 2nd finger (HP:0004100)2.50828468
66Recurrent corneal erosions (HP:0000495)2.45471537
67Visual hallucinations (HP:0002367)2.45047735
68Limb dystonia (HP:0002451)2.45029859
69Failure to thrive in infancy (HP:0001531)2.44130142
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.40680427
71Hypoplasia of the brainstem (HP:0002365)2.40132897
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40132897
73Sleep apnea (HP:0010535)2.40050896
74Action tremor (HP:0002345)2.39938966
75Neuroblastoma (HP:0003006)2.37908993
76Primitive neuroectodermal tumor (HP:0030065)2.37908993
77Neuroblastic tumors (HP:0004376)2.37908993
78Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.37908993
79Facial asymmetry (HP:0000324)2.37360966
80Palpebral edema (HP:0100540)2.35840618
81Partial agenesis of the corpus callosum (HP:0001338)2.35709144
82Sandal gap (HP:0001852)2.31460975
83Attenuation of retinal blood vessels (HP:0007843)2.31436245
84Bony spicule pigmentary retinopathy (HP:0007737)2.31003562
85Midline defect of the nose (HP:0004122)2.30989004
86Abnormal hair whorl (HP:0010721)2.30610267
87Distal lower limb amyotrophy (HP:0008944)2.29072918
88Annular pancreas (HP:0001734)2.26926182
89Abnormality of the labia minora (HP:0012880)2.26775563
90Blue irides (HP:0000635)2.26762154
91Progressive inability to walk (HP:0002505)2.25088368
92Lower limb asymmetry (HP:0100559)2.19970861
93Amblyopia (HP:0000646)2.18958136
94Genetic anticipation (HP:0003743)2.17235373
95Bradycardia (HP:0001662)2.17127027
96Abnormality of the pubic bones (HP:0003172)2.15138425
97Abnormality of the lower motor neuron (HP:0002366)2.11330880
98Depressed nasal tip (HP:0000437)2.10597741
99Lissencephaly (HP:0001339)2.09745557
100Septo-optic dysplasia (HP:0100842)2.09443227
101Nephronophthisis (HP:0000090)2.07519202
102Stereotypic behavior (HP:0000733)2.05750149
103Disproportionate short-trunk short stature (HP:0003521)2.03492137
104Abnormality of chromosome stability (HP:0003220)2.02730803
105Dysmetria (HP:0001310)2.02656164
106Protruding ear (HP:0000411)2.02620106
107Split foot (HP:0001839)2.01798643
108Abnormal EKG (HP:0003115)2.01615445
109Peripheral hypomyelination (HP:0007182)2.01205108
110Abnormality of the duodenum (HP:0002246)1.99513964
111Morphological abnormality of the pyramidal tract (HP:0002062)1.97525914
112Bilateral microphthalmos (HP:0007633)1.96534278
113Urinary bladder sphincter dysfunction (HP:0002839)1.96300576
114Thyroid carcinoma (HP:0002890)1.96062188
115Protruding tongue (HP:0010808)1.95519451
116Orthostatic hypotension (HP:0001278)1.94124500
117Anosmia (HP:0000458)1.93987233
118Urinary urgency (HP:0000012)1.93413328
119Abnormality of intracranial pressure (HP:0012640)1.92878753
120Increased intracranial pressure (HP:0002516)1.92878753
121Obstructive sleep apnea (HP:0002870)1.92670947
122Abnormality of calcium-phosphate metabolism (HP:0100530)1.92356811
123Bradykinesia (HP:0002067)1.92109078
124Abnormality of dental color (HP:0011073)1.91613073
125Long nose (HP:0003189)1.91273354
126Spinal canal stenosis (HP:0003416)1.90303934
127Back pain (HP:0003418)1.90275708
128Overlapping toe (HP:0001845)1.89978079
129Hip dysplasia (HP:0001385)1.89963852
130Abnormality of the parietal bone (HP:0002696)1.89931300
131High anterior hairline (HP:0009890)1.89695133
132Hypothermia (HP:0002045)1.88678616
133Short 4th metacarpal (HP:0010044)1.87477809
134Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87477809
135Abnormality of the carotid arteries (HP:0005344)1.86553594
136Malignant neoplasm of the central nervous system (HP:0100836)1.86526076
137Medulloblastoma (HP:0002885)1.85875187
138Gastrointestinal atresia (HP:0002589)1.85237821
139Abnormality of macular pigmentation (HP:0008002)1.84902674
140Epileptiform EEG discharges (HP:0011182)1.84646101
141Drooling (HP:0002307)1.83182136
142Excessive salivation (HP:0003781)1.83182136
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82225137
144Severe Myopia (HP:0011003)1.81740111
145Septate vagina (HP:0001153)1.81048990
146Severe visual impairment (HP:0001141)1.81020096
147Colon cancer (HP:0003003)1.80915200
148Spastic gait (HP:0002064)1.79118753
149Impaired vibratory sensation (HP:0002495)1.78146235
150Cutaneous finger syndactyly (HP:0010554)1.77331148
151Meckel diverticulum (HP:0002245)1.76569194
152Secondary amenorrhea (HP:0000869)1.75699649
153EEG with generalized epileptiform discharges (HP:0011198)1.75313331
154Status epilepticus (HP:0002133)1.74698540
155Optic nerve hypoplasia (HP:0000609)1.74528410
156Lower limb muscle weakness (HP:0007340)1.73949586
157Specific learning disability (HP:0001328)1.73678675
158Gait imbalance (HP:0002141)1.73038766
159Rhabdomyosarcoma (HP:0002859)1.72892627
160Ankyloglossia (HP:0010296)1.71609849
161* Poor suck (HP:0002033)1.71048252
162Abnormality of the ileum (HP:0001549)1.70932705
163Papilledema (HP:0001085)1.70909056
164Pointed chin (HP:0000307)1.70355943
165Narrow forehead (HP:0000341)1.69229883
166Absent speech (HP:0001344)1.68948277
167Abnormality of saccadic eye movements (HP:0000570)1.68628572
168Onion bulb formation (HP:0003383)1.68169496
169Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.68022871
170Aplasia involving bones of the extremities (HP:0009825)1.67243847
171Aplasia involving bones of the upper limbs (HP:0009823)1.67243847
172Aplasia of the phalanges of the hand (HP:0009802)1.67243847
173Central scotoma (HP:0000603)1.66192809
174Asplenia (HP:0001746)1.66095973
175Gait ataxia (HP:0002066)1.65962312
176Hypermetropia (HP:0000540)1.65918475
177Bundle branch block (HP:0011710)1.64986532
178Truncal ataxia (HP:0002078)1.64605693
179Oligohydramnios (HP:0001562)1.63913678
180Decreased skull ossification (HP:0004331)1.63800911
181Pachygyria (HP:0001302)1.63766583
182Atrial fibrillation (HP:0005110)1.63202690
183Hypsarrhythmia (HP:0002521)1.62931950
184Abnormality of the epiphyses of the hand (HP:0005924)1.62775948
185Exotropia (HP:0000577)1.60389717
186Primary atrial arrhythmia (HP:0001692)1.60142771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.55284662
2EPHA45.31956666
3TLK15.17208796
4NTRK34.74811705
5CASK4.56654172
6INSRR3.73298173
7MARK12.95055647
8SIK12.92111209
9DAPK22.77179104
10MINK12.65608737
11MAP3K102.52776649
12MAP2K72.47740714
13MATK2.31698343
14MAP3K42.25419699
15PRPF4B2.17924756
16NTRK22.13068315
17MAP3K92.11246697
18SRPK12.10035196
19EPHA32.05032044
20VRK12.02258402
21TNIK1.99238623
22PLK41.82981458
23RIPK41.64049244
24DDR21.54512998
25PAK61.51556831
26PINK11.49850007
27PBK1.48570204
28SIK31.48383901
29MAPK131.48242168
30ICK1.48114508
31MAP4K21.41605388
32PLK21.40877166
33SIK21.39225889
34BMPR21.38505081
35CAMKK11.36722025
36FES1.36104984
37TNK21.35829912
38SGK21.35279747
39SGK2231.30896462
40SGK4941.30896462
41MAP3K61.28470721
42GRK11.26716469
43PRKD31.25226617
44NME21.23158777
45AKT31.22126787
46TYRO31.21356465
47CDK51.20914513
48FRK1.20427614
49DAPK11.20346543
50MAP3K121.18123486
51MUSK1.16793150
52DYRK1B1.14444066
53DYRK21.13988879
54CDK31.08679988
55* PRKCG1.08209875
56RPS6KA21.05357994
57BRD41.04422867
58* CAMK2A0.97911444
59ADRBK20.96725047
60EPHB20.96713956
61GRK50.95138265
62PRKCH0.93249688
63RPS6KA50.92894237
64CDK190.92647096
65MAP2K40.92635694
66MKNK10.92197269
67STK380.90597735
68IRAK20.89080556
69PHKG10.87981433
70PHKG20.87981433
71MKNK20.87724617
72MARK30.87694890
73WNK30.86785266
74TAF10.86666565
75DYRK1A0.83301019
76* PRKCE0.82857468
77SGK30.82210251
78CAMKK20.81232206
79BMPR1B0.79681764
80NEK60.78619702
81ERBB20.77761462
82CAMK2B0.76929156
83LATS10.76536891
84ERBB30.76051157
85NTRK10.74800308
86LIMK10.73420703
87TAOK10.73344964
88KSR10.73335482
89MAPK150.72828863
90MAP2K20.72629197
91NME10.72034759
92TRIM280.71559125
93AURKA0.68716557
94LMTK20.66830825
95STK110.66344169
96IRAK10.66328174
97KSR20.63799827
98SGK10.63672926
99ALK0.63061731
100WNK10.63001935
101BCR0.62601614
102PRKAA10.60649357
103CHEK20.59982399
104UHMK10.58992785
105YES10.58932645
106PRKD20.58834396
107RPS6KL10.58280471
108RPS6KC10.58280471
109CDK180.57505309
110CDC42BPA0.56604430
111MAP3K70.56573138
112ADRBK10.54957576
113DAPK30.54738941
114STK160.53607985
115GRK70.52816988
116CDK150.52216921
117MAP3K130.52111259
118PRKACA0.51727257
119CAMK10.51615602
120CSNK1A1L0.51449672
121MAP3K20.51171052
122RPS6KA60.50270405
123CSNK1G30.49916341
124PASK0.48583615
125IRAK30.48529443
126BCKDK0.47180284
127CDK140.46696693
128PKN10.46656191
129* PRKCB0.45929594
130CAMK2D0.45849804
131RPS6KA30.45210975
132BMX0.45204687
133CSNK1G10.45168350
134CSNK1A10.44170786
135CDK11A0.44160071
136TAOK30.44052526
137CAMK1D0.43346504
138OXSR10.43197393
139* CAMK2G0.42792415
140FYN0.42652787
141CSNK1G20.42635504
142MAP2K10.42501364
143CAMK40.40276132
144CDK60.37307875
145* PRKCA0.36676831
146MAPK100.34642468
147ROCK20.34402672
148PRKACG0.34363786
149ATR0.33799221
150CDK80.32419107
151MARK20.32177543
152FGFR30.30786002
153PIM10.30476298
154CDK20.29492944
155PKN20.25934187
156AURKB0.24744284
157RET0.23067874
158FER0.22205072
159MTOR0.22147386
160CSNK1D0.21159758
161MAPK110.19911950
162CDK40.19893321

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.68950477
2Synaptic vesicle cycle_Homo sapiens_hsa047213.96246472
3Nicotine addiction_Homo sapiens_hsa050333.80027397
4Olfactory transduction_Homo sapiens_hsa047403.61771776
5Morphine addiction_Homo sapiens_hsa050323.15545258
6GABAergic synapse_Homo sapiens_hsa047272.94954284
7Circadian entrainment_Homo sapiens_hsa047132.65728230
8Phototransduction_Homo sapiens_hsa047442.59769162
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58674956
10Glutamatergic synapse_Homo sapiens_hsa047242.45397259
11Fanconi anemia pathway_Homo sapiens_hsa034602.39301295
12* Cholinergic synapse_Homo sapiens_hsa047252.31929771
13Amphetamine addiction_Homo sapiens_hsa050312.30270982
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14175103
15Cocaine addiction_Homo sapiens_hsa050302.13592327
16Taste transduction_Homo sapiens_hsa047422.10886967
17Dopaminergic synapse_Homo sapiens_hsa047282.10312516
18Serotonergic synapse_Homo sapiens_hsa047262.09301666
19Collecting duct acid secretion_Homo sapiens_hsa049662.03462736
20Long-term potentiation_Homo sapiens_hsa047201.95813011
21Salivary secretion_Homo sapiens_hsa049701.84248964
22Hedgehog signaling pathway_Homo sapiens_hsa043401.81177373
23Calcium signaling pathway_Homo sapiens_hsa040201.74956893
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.74875562
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74574593
26Insulin secretion_Homo sapiens_hsa049111.70941656
27Renin secretion_Homo sapiens_hsa049241.69553795
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59246342
29Gastric acid secretion_Homo sapiens_hsa049711.55362300
30Selenocompound metabolism_Homo sapiens_hsa004501.52311287
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51989642
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51752317
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41524522
34Oxytocin signaling pathway_Homo sapiens_hsa049211.38940417
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33043302
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32719441
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30561100
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30170938
39cAMP signaling pathway_Homo sapiens_hsa040241.27296962
40Long-term depression_Homo sapiens_hsa047301.25401787
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22868277
42Viral carcinogenesis_Homo sapiens_hsa052031.21155021
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19946919
44Colorectal cancer_Homo sapiens_hsa052101.19064199
45Cell cycle_Homo sapiens_hsa041101.17655887
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13475962
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.11266750
48mRNA surveillance pathway_Homo sapiens_hsa030151.11084735
49Prolactin signaling pathway_Homo sapiens_hsa049171.10780690
50Gap junction_Homo sapiens_hsa045401.09702749
51Basal cell carcinoma_Homo sapiens_hsa052171.09673283
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06523102
53Linoleic acid metabolism_Homo sapiens_hsa005911.03450577
54Type I diabetes mellitus_Homo sapiens_hsa049401.03131134
55Axon guidance_Homo sapiens_hsa043601.03100907
56GnRH signaling pathway_Homo sapiens_hsa049121.01835248
57Hippo signaling pathway_Homo sapiens_hsa043901.00655754
58Endometrial cancer_Homo sapiens_hsa052130.97635982
59Notch signaling pathway_Homo sapiens_hsa043300.97151531
60Non-homologous end-joining_Homo sapiens_hsa034500.97090671
61Cardiac muscle contraction_Homo sapiens_hsa042600.96325402
62Spliceosome_Homo sapiens_hsa030400.91288350
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90501246
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.89272928
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88839331
66Vibrio cholerae infection_Homo sapiens_hsa051100.88044455
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87787880
68RNA transport_Homo sapiens_hsa030130.86775141
69Ribosome_Homo sapiens_hsa030100.81775042
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81337027
71Glioma_Homo sapiens_hsa052140.80463502
72Type II diabetes mellitus_Homo sapiens_hsa049300.79550859
73Dilated cardiomyopathy_Homo sapiens_hsa054140.76638195
74Basal transcription factors_Homo sapiens_hsa030220.76624814
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76209822
76Parkinsons disease_Homo sapiens_hsa050120.76200123
77ErbB signaling pathway_Homo sapiens_hsa040120.76139282
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75726951
79TGF-beta signaling pathway_Homo sapiens_hsa043500.74831061
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74191965
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73295401
82Thyroid cancer_Homo sapiens_hsa052160.73117087
83Melanogenesis_Homo sapiens_hsa049160.71799537
84Alcoholism_Homo sapiens_hsa050340.70327451
85Oxidative phosphorylation_Homo sapiens_hsa001900.68700540
86Ras signaling pathway_Homo sapiens_hsa040140.68505282
87Choline metabolism in cancer_Homo sapiens_hsa052310.67495361
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67421609
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.66869352
90* Glycerophospholipid metabolism_Homo sapiens_hsa005640.66468082
91Ovarian steroidogenesis_Homo sapiens_hsa049130.65259833
92Rheumatoid arthritis_Homo sapiens_hsa053230.64273213
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63733908
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63511173
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63322121
96MicroRNAs in cancer_Homo sapiens_hsa052060.63287935
97Alzheimers disease_Homo sapiens_hsa050100.63092050
98Arachidonic acid metabolism_Homo sapiens_hsa005900.61393807
99Rap1 signaling pathway_Homo sapiens_hsa040150.60453075
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58825035
101Chemokine signaling pathway_Homo sapiens_hsa040620.58130531
102VEGF signaling pathway_Homo sapiens_hsa043700.57964180
103Inositol phosphate metabolism_Homo sapiens_hsa005620.54037147
104Renin-angiotensin system_Homo sapiens_hsa046140.52722523
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52179632
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51217507
107Circadian rhythm_Homo sapiens_hsa047100.50506414
108Estrogen signaling pathway_Homo sapiens_hsa049150.48865976
109MAPK signaling pathway_Homo sapiens_hsa040100.48831951
110Butanoate metabolism_Homo sapiens_hsa006500.46580632
111Tight junction_Homo sapiens_hsa045300.45841596
112Fat digestion and absorption_Homo sapiens_hsa049750.44414845
113Regulation of autophagy_Homo sapiens_hsa041400.43181612
114Lysine degradation_Homo sapiens_hsa003100.43119153
115Melanoma_Homo sapiens_hsa052180.42635512
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42621975
117Sphingolipid metabolism_Homo sapiens_hsa006000.41752164
118Phagosome_Homo sapiens_hsa041450.39402839
119Pancreatic secretion_Homo sapiens_hsa049720.39132466
120Prostate cancer_Homo sapiens_hsa052150.37638320
121DNA replication_Homo sapiens_hsa030300.36378673
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36370991
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35545634
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.34649718
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31451992
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29977717
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29099956
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28886974
129beta-Alanine metabolism_Homo sapiens_hsa004100.28728452
130Ether lipid metabolism_Homo sapiens_hsa005650.28444764
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27127696
132Oocyte meiosis_Homo sapiens_hsa041140.26512951
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26346712
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26250215
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25064249
136Wnt signaling pathway_Homo sapiens_hsa043100.24884978
137Endocytosis_Homo sapiens_hsa041440.24540290
138Thyroid hormone synthesis_Homo sapiens_hsa049180.21412989
139Insulin signaling pathway_Homo sapiens_hsa049100.21154337
140Non-small cell lung cancer_Homo sapiens_hsa052230.20939575
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19900150
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.19175100
143Huntingtons disease_Homo sapiens_hsa050160.17085404
144African trypanosomiasis_Homo sapiens_hsa051430.16228387

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