ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.01109034
2	ATP synthesis coupled proton transport (GO:0015986)	7.51719373
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.51719373
4	ribosomal small subunit biogenesis (GO:0042274)	6.79290888
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.72407184
6	viral transcription (GO:0019083)	6.57518533
7	ribosomal small subunit assembly (GO:0000028)	6.41742425
8	translational termination (GO:0006415)	6.37090131
9	respiratory electron transport chain (GO:0022904)	6.03021160
10	electron transport chain (GO:0022900)	5.87933274
11	cotranslational protein targeting to membrane (GO:0006613)	5.77522325
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.75613331
13	protein targeting to ER (GO:0045047)	5.69430825
14	maturation of SSU-rRNA (GO:0030490)	5.44352126
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.43656006
16	protein localization to endoplasmic reticulum (GO:0070972)	5.43211797
17	translational elongation (GO:0006414)	5.37518131
18	protein neddylation (GO:0045116)	5.11809214
19	cellular protein complex disassembly (GO:0043624)	5.02163586
20	viral life cycle (GO:0019058)	5.00926592
21	proteasome assembly (GO:0043248)	4.97352546
22	ribosomal large subunit biogenesis (GO:0042273)	4.89619889
23	chaperone-mediated protein transport (GO:0072321)	4.88550454
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.80372678
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.80372678
26	NADH dehydrogenase complex assembly (GO:0010257)	4.80372678
27	protein complex biogenesis (GO:0070271)	4.78950116
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.69324745
29	translational initiation (GO:0006413)	4.66160943
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.50732105
31	translation (GO:0006412)	4.50105656
32	GTP biosynthetic process (GO:0006183)	4.49911238
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.44416016
34	establishment of integrated proviral latency (GO:0075713)	4.28536608
35	termination of RNA polymerase III transcription (GO:0006386)	4.22351042
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.22351042
37	protein complex disassembly (GO:0043241)	4.19956618
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.04688387
39	macromolecular complex disassembly (GO:0032984)	4.02697743
40	regulation of mitochondrial translation (GO:0070129)	4.00301496
41	chromatin remodeling at centromere (GO:0031055)	3.98379085
42	CENP-A containing nucleosome assembly (GO:0034080)	3.92103150
43	UTP biosynthetic process (GO:0006228)	3.91478566
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.84858165
45	regulation of cellular amino acid metabolic process (GO:0006521)	3.81355178
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.78990138
47	negative regulation of ligase activity (GO:0051352)	3.77743510
48	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.77743510
49	establishment of viral latency (GO:0019043)	3.73001264
50	rRNA modification (GO:0000154)	3.72418980
51	protein targeting to membrane (GO:0006612)	3.71516938
52	cellular component biogenesis (GO:0044085)	3.69801271
53	DNA deamination (GO:0045006)	3.69366938
54	oxidative phosphorylation (GO:0006119)	3.69278465
55	respiratory chain complex IV assembly (GO:0008535)	3.68953784
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.68953374
57	cullin deneddylation (GO:0010388)	3.68701822
58	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.67890000
59	ATP biosynthetic process (GO:0006754)	3.66271573
60	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.65299138
61	protein targeting to mitochondrion (GO:0006626)	3.63810585
62	7-methylguanosine mRNA capping (GO:0006370)	3.63286837
63	guanosine-containing compound biosynthetic process (GO:1901070)	3.62681105
64	RNA capping (GO:0036260)	3.61962506
65	7-methylguanosine RNA capping (GO:0009452)	3.61962506
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.61366509
67	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.57662477
68	establishment of protein localization to mitochondrion (GO:0072655)	3.57287095
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.56698173
70	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.56342670
71	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.56342670
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.53507276
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.51251805
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.51178648
75	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.51178648
76	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.51178648
77	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.49349259
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.49349259
79	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.45480213
80	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.42518308
81	UTP metabolic process (GO:0046051)	3.41548945
82	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.41516219
83	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.41064261
84	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.41064261
85	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.40967757
86	protein deneddylation (GO:0000338)	3.40491258
87	mitochondrial transport (GO:0006839)	3.39344818
88	hydrogen ion transmembrane transport (GO:1902600)	3.38816380
89	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.38144340
90	DNA damage response, detection of DNA damage (GO:0042769)	3.36790789
91	spliceosomal complex assembly (GO:0000245)	3.35275429
92	protein localization to mitochondrion (GO:0070585)	3.32084005
93	CTP metabolic process (GO:0046036)	3.31953840
94	CTP biosynthetic process (GO:0006241)	3.31953840
95	rRNA processing (GO:0006364)	3.30982680
96	spliceosomal snRNP assembly (GO:0000387)	3.30860256
97	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.30446208
98	cytochrome complex assembly (GO:0017004)	3.29648898
99	inner mitochondrial membrane organization (GO:0007007)	3.25590655
100	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.24936459
101	intracellular protein transmembrane import (GO:0044743)	3.24722519
102	nucleoside triphosphate biosynthetic process (GO:0009142)	3.23351165
103	mRNA catabolic process (GO:0006402)	3.21995111
104	formation of translation preinitiation complex (GO:0001731)	3.17936056
105	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.17221099
106	rRNA metabolic process (GO:0016072)	3.17012489
107	DNA replication checkpoint (GO:0000076)	3.15096371
108	aerobic respiration (GO:0009060)	3.14481011
109	RNA catabolic process (GO:0006401)	3.14167067
110	pseudouridine synthesis (GO:0001522)	3.13161772
111	peptidyl-histidine modification (GO:0018202)	3.12434466
112	water-soluble vitamin biosynthetic process (GO:0042364)	3.12405898
113	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.11092460
114	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.10863181
115	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.10746902
116	histone exchange (GO:0043486)	3.10709513
117	kinetochore assembly (GO:0051382)	3.09348680
118	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.08367903
119	proton transport (GO:0015992)	3.03547509

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.83825662
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.16920761
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.61868003
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.43998102
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.11782404
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.91275737
7	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.83927772
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.62473370
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.57588684
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.49884106
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.36377848
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.29967680
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.29094364
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.25849503
15	* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.03939396
16	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.87632214
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.60165978
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53934135
19	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.52504712
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.51037698
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37896464
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.33653351
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.32015272
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27607726
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27149045
26	XRN2_22483619_ChIP-Seq_HELA_Human	2.22494297
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.17429679
28	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.15663140
29	TTF2_22483619_ChIP-Seq_HELA_Human	2.14706562
30	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07671309
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.06789513
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.01534618
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.97391401
34	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.93791214
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79241202
36	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.73627554
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.72730052
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.65531866
39	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.63956600
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62689709
41	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.61728616
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.58181301
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57877918
44	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.52747904
45	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.49503531
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.48856144
47	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.42008564
48	VDR_22108803_ChIP-Seq_LS180_Human	1.41282690
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36511107
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36074239
51	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.35784527
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.28418299
53	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.28352953
54	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.26227281
55	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.24949059
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22790701
57	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21337655
58	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18129530
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16104220
60	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.15828537
61	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15653391
62	ZNF263_19887448_ChIP-Seq_K562_Human	1.15557923
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14088874
64	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.13592953
65	FUS_26573619_Chip-Seq_HEK293_Human	1.12451519
66	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.07878061
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.07537154
68	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.07347100
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.03663826
70	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.01556139
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.99723284
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98854140
73	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98442479
74	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.95898926
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95055686
76	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.92088511
77	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.91320037
78	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.91246537
79	EWS_26573619_Chip-Seq_HEK293_Human	0.90034631
80	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89039183
81	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.85315301
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.82953191
83	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.82088270
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.81571080
85	* FOXP1_21924763_ChIP-Seq_HESCs_Human	0.81183081
86	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.80807772
87	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.79483802
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.78237595
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.77994103
90	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.77889255
91	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.77261420
92	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.75714973
93	AR_21909140_ChIP-Seq_LNCAP_Human	0.75016830
94	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.74392042
95	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.73206400
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.73142412
97	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.72811110
98	EZH2_22144423_ChIP-Seq_EOC_Human	0.72155891
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.72072360
100	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.71516901
101	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.70819585
102	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.70144482
103	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.69042466
104	* NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.68843924
105	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.68312290
106	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.67897004
107	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.67737116
108	* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.67334282
109	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.67195064
110	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.67152524
111	ELF5_23300383_ChIP-Seq_T47D_Human	0.66919243
112	CIITA_25753668_ChIP-Seq_RAJI_Human	0.65717861
113	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.65604030
114	* SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.64608797
115	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.62338461
116	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.62042303
117	STAT1_20625510_ChIP-Seq_HELA_Human	0.61174286
118	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.61020888

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.19405922
2	MP0001529_abnormal_vocalization	3.87716603
3	MP0003136_yellow_coat_color	3.14033426
4	MP0001905_abnormal_dopamine_level	2.69870073
5	MP0006036_abnormal_mitochondrial_physio	2.46754820
6	MP0003693_abnormal_embryo_hatching	2.39677322
7	MP0003880_abnormal_central_pattern	2.38826813
8	MP0004957_abnormal_blastocyst_morpholog	2.37488205
9	MP0002638_abnormal_pupillary_reflex	2.26817925
10	MP0003941_abnormal_skin_development	2.22481594
11	MP0006276_abnormal_autonomic_nervous	2.19632210
12	MP0006292_abnormal_olfactory_placode	2.16924076
13	MP0010030_abnormal_orbit_morphology	2.12143512
14	MP0003186_abnormal_redox_activity	2.09999469
15	MP0003806_abnormal_nucleotide_metabolis	2.05628302
16	MP0006035_abnormal_mitochondrial_morpho	1.99065577
17	MP0008932_abnormal_embryonic_tissue	1.97122270
18	MP0004142_abnormal_muscle_tone	1.88839350
19	MP0003718_maternal_effect	1.87795029
20	MP0002938_white_spotting	1.81947426
21	MP0000372_irregular_coat_pigmentation	1.79520055
22	MP0001293_anophthalmia	1.79142035
23	MP0001188_hyperpigmentation	1.75437937
24	MP0005084_abnormal_gallbladder_morpholo	1.75351165
25	MP0001986_abnormal_taste_sensitivity	1.74629444
26	MP0002102_abnormal_ear_morphology	1.70643151
27	MP0004147_increased_porphyrin_level	1.63352414
28	MP0000566_synostosis	1.63148981
29	MP0008057_abnormal_DNA_replication	1.62291497
30	MP0008007_abnormal_cellular_replicative	1.61595977
31	MP0001485_abnormal_pinna_reflex	1.58127452
32	MP0008058_abnormal_DNA_repair	1.57329549
33	MP0005409_darkened_coat_color	1.57289703
34	MP0002163_abnormal_gland_morphology	1.53944537
35	MP0001727_abnormal_embryo_implantation	1.52638106
36	MP0002160_abnormal_reproductive_system	1.45556301
37	MP0010094_abnormal_chromosome_stability	1.45418743
38	MP0004381_abnormal_hair_follicle	1.44271649
39	MP0009697_abnormal_copulation	1.39950001
40	MP0002653_abnormal_ependyma_morphology	1.39519992
41	MP0003077_abnormal_cell_cycle	1.37679868
42	MP0002837_dystrophic_cardiac_calcinosis	1.36797909
43	MP0008789_abnormal_olfactory_epithelium	1.35248513
44	MP0003315_abnormal_perineum_morphology	1.31994078
45	MP0005408_hypopigmentation	1.31437559
46	MP0004145_abnormal_muscle_electrophysio	1.31215752
47	MP0003786_premature_aging	1.30883589
48	MP0002277_abnormal_respiratory_mucosa	1.29745435
49	MP0003950_abnormal_plasma_membrane	1.29648110
50	MP0000749_muscle_degeneration	1.23312468
51	MP0002736_abnormal_nociception_after	1.23114775
52	MP0002132_abnormal_respiratory_system	1.19859196
53	MP0005171_absent_coat_pigmentation	1.16494356
54	MP0002210_abnormal_sex_determination	1.15864837
55	MP0006072_abnormal_retinal_apoptosis	1.15074415
56	MP0002751_abnormal_autonomic_nervous	1.14964353
57	MP0005423_abnormal_somatic_nervous	1.14500945
58	MP0003937_abnormal_limbs/digits/tail_de	1.10628535
59	MP0001968_abnormal_touch/_nociception	1.09304370
60	MP0000920_abnormal_myelination	1.08627691
61	MP0005389_reproductive_system_phenotype	1.08472659
62	MP0005174_abnormal_tail_pigmentation	1.07788461
63	MP0002272_abnormal_nervous_system	1.05901181
64	MP0004133_heterotaxia	1.05094196
65	MP0003011_delayed_dark_adaptation	1.04783724
66	MP0000350_abnormal_cell_proliferation	1.01750039
67	MP0000026_abnormal_inner_ear	1.00587312
68	MP0003121_genomic_imprinting	0.98323474
69	MP0003938_abnormal_ear_development	0.97780009
70	MP0005379_endocrine/exocrine_gland_phen	0.96969445
71	MP0005451_abnormal_body_composition	0.96637390
72	MP0003646_muscle_fatigue	0.96504200
73	MP0004742_abnormal_vestibular_system	0.96431835
74	MP0008875_abnormal_xenobiotic_pharmacok	0.95276897
75	MP0005075_abnormal_melanosome_morpholog	0.94127329
76	MP0003137_abnormal_impulse_conducting	0.93228226
77	MP0001286_abnormal_eye_development	0.92829012
78	MP0000049_abnormal_middle_ear	0.92788735
79	MP0001145_abnormal_male_reproductive	0.92765995
80	MP0000358_abnormal_cell_content/	0.92544477
81	MP0002735_abnormal_chemical_nociception	0.90156758
82	MP0004215_abnormal_myocardial_fiber	0.89886895
83	MP0002697_abnormal_eye_size	0.89312088
84	MP0002734_abnormal_mechanical_nocicepti	0.88670147
85	MP0002233_abnormal_nose_morphology	0.88291827
86	MP0001764_abnormal_homeostasis	0.88287191
87	MP0001919_abnormal_reproductive_system	0.87852839
88	MP0001963_abnormal_hearing_physiology	0.87521218
89	MP0001697_abnormal_embryo_size	0.86779049
90	MP0000653_abnormal_sex_gland	0.86128052
91	MP0009046_muscle_twitch	0.85062119
92	MP0000313_abnormal_cell_death	0.84070332
93	MP0005253_abnormal_eye_physiology	0.83480209
94	MP0001440_abnormal_grooming_behavior	0.83089840
95	MP0002148_abnormal_hypersensitivity_rea	0.83079738
96	MP0002090_abnormal_vision	0.82909420
97	MP0001929_abnormal_gametogenesis	0.82652473
98	MP0000750_abnormal_muscle_regeneration	0.82651528
99	MP0003111_abnormal_nucleus_morphology	0.82384913
100	MP0005646_abnormal_pituitary_gland	0.81973828
101	MP0002752_abnormal_somatic_nervous	0.80931185
102	MP0002234_abnormal_pharynx_morphology	0.80496284
103	MP0005266_abnormal_metabolism	0.79942433
104	MP0005645_abnormal_hypothalamus_physiol	0.79493309
105	MP0002095_abnormal_skin_pigmentation	0.78601504
106	MP0002085_abnormal_embryonic_tissue	0.77460108
107	MP0009333_abnormal_splenocyte_physiolog	0.77441686
108	MP0002876_abnormal_thyroid_physiology	0.77312074
109	MP0002332_abnormal_exercise_endurance	0.76517981
110	MP0001730_embryonic_growth_arrest	0.76046963
111	MP0002111_abnormal_tail_morphology	0.75984832
112	MP0005394_taste/olfaction_phenotype	0.73320286
113	MP0005499_abnormal_olfactory_system	0.73320286
114	MP0000631_abnormal_neuroendocrine_gland	0.72856908
115	MP0004019_abnormal_vitamin_homeostasis	0.72835388
116	MP0003123_paternal_imprinting	0.72499841
117	MP0008995_early_reproductive_senescence	0.72054248
118	MP0001970_abnormal_pain_threshold	0.71541085
119	MP0005410_abnormal_fertilization	0.71217193
120	MP0005332_abnormal_amino_acid	0.70920442
121	MP0003119_abnormal_digestive_system	0.70066862
122	MP0005551_abnormal_eye_electrophysiolog	0.69861156
123	MP0001881_abnormal_mammary_gland	0.69768820
124	MP0008877_abnormal_DNA_methylation	0.68597250
125	MP0001984_abnormal_olfaction	0.68583867
126	MP0000778_abnormal_nervous_system	0.68430438
127	MP0009250_abnormal_appendicular_skeleto	0.67846144
128	MP0009785_altered_susceptibility_to	0.66326496
129	MP0005636_abnormal_mineral_homeostasis	0.65168514
130	MP0000537_abnormal_urethra_morphology	0.65135614
131	MP0000647_abnormal_sebaceous_gland	0.64839546
132	MP0003221_abnormal_cardiomyocyte_apopto	0.64470195
133	MP0002106_abnormal_muscle_physiology	0.64445838
134	MP0003724_increased_susceptibility_to	0.64035699
135	MP0005376_homeostasis/metabolism_phenot	0.63997947
136	MP0005380_embryogenesis_phenotype	0.63345065
137	MP0001672_abnormal_embryogenesis/_devel	0.63345065
138	MP0003567_abnormal_fetal_cardiomyocyte	0.63329928
139	MP0000015_abnormal_ear_pigmentation	0.63288897
140	MP0003890_abnormal_embryonic-extraembry	0.62912684
141	MP0008872_abnormal_physiological_respon	0.62774331
142	MP0002177_abnormal_outer_ear	0.62769312
143	MP0005391_vision/eye_phenotype	0.62194203

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.82758587
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.13738490
3	Mitochondrial inheritance (HP:0001427)	6.07843183
4	Progressive macrocephaly (HP:0004481)	5.61735193
5	Acute encephalopathy (HP:0006846)	5.55825505
6	Increased hepatocellular lipid droplets (HP:0006565)	5.41427893
7	Abnormality of cells of the erythroid lineage (HP:0012130)	5.22736980
8	Increased CSF lactate (HP:0002490)	5.20739040
9	Hepatocellular necrosis (HP:0001404)	5.12080776
10	Lipid accumulation in hepatocytes (HP:0006561)	4.79650652
11	Renal Fanconi syndrome (HP:0001994)	4.72269448
12	Abnormal number of erythroid precursors (HP:0012131)	4.68136544
13	Hepatic necrosis (HP:0002605)	4.48263327
14	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.45360049
15	3-Methylglutaconic aciduria (HP:0003535)	4.33469306
16	Abnormality of glycolysis (HP:0004366)	4.30575852
17	Increased serum pyruvate (HP:0003542)	4.30575852
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	4.21452828
19	Reticulocytopenia (HP:0001896)	4.20538073
20	Increased intramyocellular lipid droplets (HP:0012240)	4.04554762
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.03928469
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.03928469
23	Cerebral edema (HP:0002181)	3.87378656
24	Exercise intolerance (HP:0003546)	3.86452716
25	Exertional dyspnea (HP:0002875)	3.77461193
26	Macrocytic anemia (HP:0001972)	3.71122224
27	Increased serum lactate (HP:0002151)	3.61883269
28	Respiratory failure (HP:0002878)	3.54926753
29	Leukodystrophy (HP:0002415)	3.52401591
30	Optic disc pallor (HP:0000543)	3.50114848
31	Lactic acidosis (HP:0003128)	3.41712657
32	Increased muscle lipid content (HP:0009058)	3.35910649
33	Pallor (HP:0000980)	3.25097591
34	Respiratory difficulties (HP:0002880)	3.24018314
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.14069191
36	Parakeratosis (HP:0001036)	3.13800666
37	Abnormality of renal resorption (HP:0011038)	3.09018146
38	Microvesicular hepatic steatosis (HP:0001414)	2.73337795
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.59311155
40	Cerebral hypomyelination (HP:0006808)	2.47572388
41	Hyperglycinemia (HP:0002154)	2.41553405
42	Glycosuria (HP:0003076)	2.28563750
43	Abnormality of urine glucose concentration (HP:0011016)	2.28563750
44	CNS demyelination (HP:0007305)	2.25654801
45	Congenital ichthyosiform erythroderma (HP:0007431)	2.24111456
46	Hyperphosphaturia (HP:0003109)	2.19325542
47	Degeneration of anterior horn cells (HP:0002398)	2.18995462
48	Abnormality of the anterior horn cell (HP:0006802)	2.18995462
49	X-linked dominant inheritance (HP:0001423)	2.18838757
50	Emotional lability (HP:0000712)	2.16769860
51	Aplastic anemia (HP:0001915)	2.15442007
52	Abnormality of placental membranes (HP:0011409)	2.12470542
53	Amniotic constriction ring (HP:0009775)	2.12470542
54	Abnormality of serum amino acid levels (HP:0003112)	2.07324101
55	Microretrognathia (HP:0000308)	2.06781362
56	Colon cancer (HP:0003003)	2.06444715
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06045820
58	Abnormality of alanine metabolism (HP:0010916)	2.06045820
59	Type I transferrin isoform profile (HP:0003642)	2.05756277
60	Reduced antithrombin III activity (HP:0001976)	2.05385891
61	Cleft eyelid (HP:0000625)	2.01318130
62	Abnormality of methionine metabolism (HP:0010901)	2.00998229
63	Absent thumb (HP:0009777)	2.00586241
64	Testicular atrophy (HP:0000029)	1.97692771
65	Lethargy (HP:0001254)	1.97023249
66	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95259997
67	Oral leukoplakia (HP:0002745)	1.94161730
68	Abnormal protein glycosylation (HP:0012346)	1.93732284
69	Abnormal glycosylation (HP:0012345)	1.93732284
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93732284
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.93732284
72	Meckel diverticulum (HP:0002245)	1.92857667
73	Birth length less than 3rd percentile (HP:0003561)	1.92582057
74	Abnormality of the axillary hair (HP:0100134)	1.91289111
75	Abnormality of secondary sexual hair (HP:0009888)	1.91289111
76	Generalized aminoaciduria (HP:0002909)	1.89951910
77	Abnormal urine phosphate concentration (HP:0012599)	1.88796214
78	Megaloblastic anemia (HP:0001889)	1.86934788
79	Renal tubular dysfunction (HP:0000124)	1.86862355
80	Hypothermia (HP:0002045)	1.86505759
81	Abnormal hemoglobin (HP:0011902)	1.85267472
82	Stenosis of the external auditory canal (HP:0000402)	1.82983742
83	Abnormality of the ileum (HP:0001549)	1.82239935
84	Sclerocornea (HP:0000647)	1.81165482
85	Congenital, generalized hypertrichosis (HP:0004540)	1.81037812
86	Sparse eyelashes (HP:0000653)	1.79056932
87	Abnormal number of incisors (HP:0011064)	1.77944757
88	Partial duplication of thumb phalanx (HP:0009944)	1.77635567
89	Sensory axonal neuropathy (HP:0003390)	1.76074983
90	Pancreatic fibrosis (HP:0100732)	1.75349540
91	Muscle hypertrophy of the lower extremities (HP:0008968)	1.73991001
92	Blindness (HP:0000618)	1.73425306
93	Gout (HP:0001997)	1.72392481
94	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.70781741
95	Abnormality of midbrain morphology (HP:0002418)	1.69803372
96	Molar tooth sign on MRI (HP:0002419)	1.69803372
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69718036
98	Myokymia (HP:0002411)	1.68055273
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.67590752
100	Abnormality of the preputium (HP:0100587)	1.66920948
101	Breast hypoplasia (HP:0003187)	1.66567521
102	Horseshoe kidney (HP:0000085)	1.66553155
103	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.65967888
104	Dicarboxylic aciduria (HP:0003215)	1.65967888
105	Abnormality of the septum pellucidum (HP:0007375)	1.64810730
106	Hypoplastic pelvis (HP:0008839)	1.63859698
107	Abnormal pupillary function (HP:0007686)	1.61399915
108	Medial flaring of the eyebrow (HP:0010747)	1.60945137
109	Rough bone trabeculation (HP:0100670)	1.60025960
110	Pancytopenia (HP:0001876)	1.59175582
111	Progressive external ophthalmoplegia (HP:0000590)	1.57758868
112	Duplicated collecting system (HP:0000081)	1.56235789
113	Gliosis (HP:0002171)	1.53392687
114	Neuroendocrine neoplasm (HP:0100634)	1.53127061
115	Hypoplasia of the uterus (HP:0000013)	1.52965231
116	Absent septum pellucidum (HP:0001331)	1.52945276
117	Septo-optic dysplasia (HP:0100842)	1.52616519
118	Poor head control (HP:0002421)	1.51854801
119	Hypoplastic left heart (HP:0004383)	1.49783023
120	Partial duplication of the phalanx of hand (HP:0009999)	1.49741530
121	Nasolacrimal duct obstruction (HP:0000579)	1.48405038
122	Methylmalonic acidemia (HP:0002912)	1.46726808
123	Multiple enchondromatosis (HP:0005701)	1.46611228
124	CNS hypomyelination (HP:0003429)	1.46050981
125	Pancreatic cysts (HP:0001737)	1.45731507
126	Triphalangeal thumb (HP:0001199)	1.45054355
127	Methylmalonic aciduria (HP:0012120)	1.44096288
128	Duplication of thumb phalanx (HP:0009942)	1.43052546
129	Abnormal respiratory epithelium morphology (HP:0012253)	1.42939793
130	Abnormal respiratory motile cilium morphology (HP:0005938)	1.42939793
131	Calf muscle hypertrophy (HP:0008981)	1.42757643
132	Type 2 muscle fiber atrophy (HP:0003554)	1.39647783
133	11 pairs of ribs (HP:0000878)	1.38092128
134	Glossoptosis (HP:0000162)	1.37533051
135	Abnormality of the renal collecting system (HP:0004742)	1.37269447
136	Hyperalaninemia (HP:0003348)	1.35860734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.53442095
2	NME2	3.89131053
3	STK16	3.77539075
4	BUB1	3.24396290
5	PBK	2.96262781
6	EIF2AK1	2.88737590
7	VRK1	2.85268457
8	NME1	2.80169538
9	STK39	2.46151786
10	SRPK1	2.44652942
11	MST4	2.31520599
12	WEE1	2.29701947
13	NEK1	2.24781421
14	TLK1	2.03337293
15	EIF2AK3	1.99887778
16	MKNK1	1.83583354
17	CASK	1.82006742
18	MAP3K12	1.66007872
19	OXSR1	1.61470353
20	BMPR1B	1.57070941
21	BCR	1.56193955
22	MUSK	1.52213669
23	PLK4	1.47895638
24	LIMK1	1.47283851
25	MYLK	1.46180783
26	ARAF	1.44122822
27	OBSCN	1.43751349
28	CDK19	1.43298759
29	PNCK	1.41517857
30	PDK2	1.41406478
31	PIM2	1.40731606
32	DYRK2	1.39311191
33	BLK	1.31748982
34	TAF1	1.30311127
35	NUAK1	1.29112158
36	ADRBK2	1.28443227
37	GRK7	1.26628443
38	WNK4	1.14596598
39	EIF2AK2	1.10880436
40	MAPKAPK5	1.09805994
41	TRIM28	1.05663528
42	CSNK1G3	1.04474743
43	CHEK2	1.03749144
44	ABL2	0.99753834
45	AURKA	0.98903038
46	MKNK2	0.96505591
47	CDC7	0.94136115
48	YES1	0.89534896
49	TNIK	0.88847309
50	STK4	0.86709878
51	BMPR2	0.85038196
52	IRAK4	0.84942837
53	BRSK1	0.84145070
54	BRAF	0.83146764
55	BRSK2	0.82390954
56	TESK2	0.82374281
57	UHMK1	0.81761160
58	ACVR1B	0.81114636
59	TSSK6	0.80174280
60	CDK8	0.79820017
61	BCKDK	0.78464954
62	ATR	0.78353816
63	MAPK13	0.78315241
64	CSNK2A1	0.76735272
65	AURKB	0.76330302
66	CSNK2A2	0.75451539
67	RPS6KA5	0.75357386
68	ILK	0.75223956
69	MAP4K2	0.74521666
70	ZAK	0.74365617
71	RPS6KA4	0.73362805
72	PAK4	0.72625493
73	KDR	0.72476063
74	PKN1	0.71247151
75	PLK3	0.71113862
76	DYRK3	0.70659346
77	PLK1	0.70291100
78	LRRK2	0.69637061
79	MAP3K4	0.68210874
80	CAMK2B	0.68012990
81	MAP2K7	0.66314795
82	TESK1	0.66302022
83	CLK1	0.65491199
84	EPHB2	0.64241860
85	RPS6KB2	0.62532790
86	GRK5	0.61054397
87	CCNB1	0.57580530
88	PASK	0.55847363
89	DAPK1	0.51944734
90	CSNK1G1	0.51840505
91	PAK1	0.50595605
92	CHEK1	0.49860394
93	ADRBK1	0.49609373
94	CSNK1E	0.49359453
95	PRKCG	0.49322503
96	ROCK2	0.46527615
97	MARK1	0.45933308
98	CAMK2D	0.45820320
99	NEK2	0.44547662
100	PRKCI	0.44241253
101	CAMK2G	0.42487389
102	PLK2	0.41469274
103	TTK	0.41024981
104	INSRR	0.40952234
105	MINK1	0.40862820
106	FGR	0.40766933
107	ATM	0.40685455
108	CDK7	0.40124419
109	CAMK2A	0.39187322
110	DMPK	0.39123343
111	PIK3CG	0.37850057
112	CSNK1A1L	0.37836494
113	CSNK1A1	0.37411489
114	NEK6	0.37262349
115	PRKACA	0.37099711
116	LYN	0.37000096
117	GRK1	0.36689569
118	MAP2K6	0.35436786
119	TEC	0.33739938
120	CDK14	0.33539140
121	DAPK3	0.33162061
122	CSNK1G2	0.31076299
123	WNK3	0.30391951
124	IRAK2	0.29665932
125	TXK	0.29561896
126	IRAK3	0.28982698
127	PRKCE	0.28852448
128	CDK11A	0.28446426
129	EPHA2	0.27842579
130	MAP3K8	0.27322008
131	PIM1	0.26041923
132	CDK3	0.25319525

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.59832905
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.10725053
3	Parkinsons disease_Homo sapiens_hsa05012	4.43441194
4	Proteasome_Homo sapiens_hsa03050	4.38289844
5	RNA polymerase_Homo sapiens_hsa03020	3.43062111
6	Huntingtons disease_Homo sapiens_hsa05016	3.27306350
7	Alzheimers disease_Homo sapiens_hsa05010	3.24757481
8	Protein export_Homo sapiens_hsa03060	3.04919909
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.78534797
10	DNA replication_Homo sapiens_hsa03030	2.38210207
11	Mismatch repair_Homo sapiens_hsa03430	2.30455196
12	Spliceosome_Homo sapiens_hsa03040	2.22974395
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.18008730
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.09355151
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.91945071
16	Homologous recombination_Homo sapiens_hsa03440	1.85103237
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84977242
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.80942673
19	Fatty acid elongation_Homo sapiens_hsa00062	1.59842745
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46412066
21	Basal transcription factors_Homo sapiens_hsa03022	1.39893519
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37950817
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34658028
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.28258839
25	Purine metabolism_Homo sapiens_hsa00230	1.26078077
26	Base excision repair_Homo sapiens_hsa03410	1.25038753
27	RNA transport_Homo sapiens_hsa03013	1.25020843
28	RNA degradation_Homo sapiens_hsa03018	1.20938340
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.20213649
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.08084494
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01431154
32	Glutathione metabolism_Homo sapiens_hsa00480	0.96534756
33	Folate biosynthesis_Homo sapiens_hsa00790	0.93234606
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91418893
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90765751
36	Metabolic pathways_Homo sapiens_hsa01100	0.85211804
37	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80287867
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78299493
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78071322
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.71503195
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70917292
42	One carbon pool by folate_Homo sapiens_hsa00670	0.69021493
43	Sulfur metabolism_Homo sapiens_hsa00920	0.68521304
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66992143
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.65729658
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.61646070
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.60978948
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56283472
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.56092931
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52397454
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52143418
52	Cell cycle_Homo sapiens_hsa04110	0.51979733
53	Sulfur relay system_Homo sapiens_hsa04122	0.51306677
54	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.51211930
55	Phenylalanine metabolism_Homo sapiens_hsa00360	0.50497139
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.50197192
57	Propanoate metabolism_Homo sapiens_hsa00640	0.49362086
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48240339
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46170627
60	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.45829826
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44510925
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42763861
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42300457
64	Histidine metabolism_Homo sapiens_hsa00340	0.42033300
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41212119
66	Allograft rejection_Homo sapiens_hsa05330	0.41016883
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40859561
68	Asthma_Homo sapiens_hsa05310	0.40261863
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39948702
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.39304334
71	Phototransduction_Homo sapiens_hsa04744	0.39096847
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38803209
73	Carbon metabolism_Homo sapiens_hsa01200	0.37700350
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36814987
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36021407
76	Peroxisome_Homo sapiens_hsa04146	0.35564720
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35420212
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.34664486
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34060327
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33207744
81	Oocyte meiosis_Homo sapiens_hsa04114	0.32617626
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32469261
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.31317848
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30770308
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.30509688
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30170220
87	Alcoholism_Homo sapiens_hsa05034	0.29431503
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28491698
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28325980
90	Pentose phosphate pathway_Homo sapiens_hsa00030	0.27824467
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.27335529
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27092656
93	Phagosome_Homo sapiens_hsa04145	0.26905047
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26499909
95	Fatty acid degradation_Homo sapiens_hsa00071	0.26336770
96	Serotonergic synapse_Homo sapiens_hsa04726	0.25895922
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.25708680
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.25362334
99	Galactose metabolism_Homo sapiens_hsa00052	0.24516737
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.23271575
101	Basal cell carcinoma_Homo sapiens_hsa05217	0.22306497
102	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.20910137
103	Chemical carcinogenesis_Homo sapiens_hsa05204	0.20111589
104	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19446169
105	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.17366454
106	Butanoate metabolism_Homo sapiens_hsa00650	0.17143482
107	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.17077335
108	Type I diabetes mellitus_Homo sapiens_hsa04940	0.15430370
109	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.15065657
110	p53 signaling pathway_Homo sapiens_hsa04115	0.14914288
111	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.14418957
112	Fat digestion and absorption_Homo sapiens_hsa04975	0.14245262
113	Caffeine metabolism_Homo sapiens_hsa00232	0.11337433
114	Retinol metabolism_Homo sapiens_hsa00830	0.10865193
115	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.10609042
116	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.10414856
117	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.10167956
118	Nitrogen metabolism_Homo sapiens_hsa00910	0.10056114
119	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.09306197
120	beta-Alanine metabolism_Homo sapiens_hsa00410	0.09096052
121	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.07953039
122	Nicotine addiction_Homo sapiens_hsa05033	0.07481712
123	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.06880243
124	Regulation of autophagy_Homo sapiens_hsa04140	0.06476440

CHCHD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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