CHCHD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle cell fate commitment (GO:0042693)6.72045679
2creatine metabolic process (GO:0006600)6.40457231
3lysine metabolic process (GO:0006553)5.70686424
4lysine catabolic process (GO:0006554)5.70686424
5muscle organ morphogenesis (GO:0048644)5.70251243
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.69348925
7L-phenylalanine metabolic process (GO:0006558)5.69348925
8L-phenylalanine catabolic process (GO:0006559)5.53133601
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53133601
10glyoxylate metabolic process (GO:0046487)5.39817522
11ribosomal small subunit biogenesis (GO:0042274)5.34013180
12cellular ketone body metabolic process (GO:0046950)5.18936905
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.16897916
14muscle filament sliding (GO:0030049)5.16496207
15actin-myosin filament sliding (GO:0033275)5.16496207
16sulfur amino acid catabolic process (GO:0000098)5.05936200
17cysteine metabolic process (GO:0006534)4.99564117
18aromatic amino acid family catabolic process (GO:0009074)4.89033909
19kynurenine metabolic process (GO:0070189)4.84906239
20aspartate family amino acid catabolic process (GO:0009068)4.81350320
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.75112652
22serine family amino acid catabolic process (GO:0009071)4.74637881
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.74577514
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73952605
25short-chain fatty acid metabolic process (GO:0046459)4.72312281
262-oxoglutarate metabolic process (GO:0006103)4.66409971
27tricarboxylic acid cycle (GO:0006099)4.65080335
28ketone body metabolic process (GO:1902224)4.61320997
29fatty acid beta-oxidation (GO:0006635)4.55850051
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.52571643
31amino-acid betaine metabolic process (GO:0006577)4.46097441
32tooth mineralization (GO:0034505)4.39073019
33tryptophan catabolic process (GO:0006569)4.37660999
34indole-containing compound catabolic process (GO:0042436)4.37660999
35indolalkylamine catabolic process (GO:0046218)4.37660999
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.33928344
37carnitine shuttle (GO:0006853)4.33553516
38fatty acid transmembrane transport (GO:1902001)4.27937780
39viral transcription (GO:0019083)4.21997179
40acetyl-CoA metabolic process (GO:0006084)4.21976534
41alpha-linolenic acid metabolic process (GO:0036109)4.21926084
42homocysteine metabolic process (GO:0050667)4.21325628
43bile acid biosynthetic process (GO:0006699)4.20468251
44ethanol oxidation (GO:0006069)4.17929656
45fatty acid oxidation (GO:0019395)4.17913143
46branched-chain amino acid catabolic process (GO:0009083)4.17671093
47alpha-amino acid catabolic process (GO:1901606)4.17456379
48lymph vessel development (GO:0001945)4.13756410
49fatty acid catabolic process (GO:0009062)4.10821876
50lipid oxidation (GO:0034440)4.10105052
51regulation of triglyceride catabolic process (GO:0010896)4.07927478
52skeletal muscle contraction (GO:0003009)4.07440259
53cellular amino acid catabolic process (GO:0009063)4.07406987
54tryptophan metabolic process (GO:0006568)4.07217325
55glycine metabolic process (GO:0006544)4.03288704
56cellular modified amino acid catabolic process (GO:0042219)4.00582196
57gluconeogenesis (GO:0006094)4.00033630
58cardiac muscle contraction (GO:0060048)3.99881165
59glutamate metabolic process (GO:0006536)3.97331291
60monocarboxylic acid catabolic process (GO:0072329)3.95151129
61amyloid precursor protein catabolic process (GO:0042987)3.93821746
62serine family amino acid metabolic process (GO:0009069)3.92245108
63dicarboxylic acid biosynthetic process (GO:0043650)3.90976683
64carnitine metabolic process (GO:0009437)3.90018616
65actin-mediated cell contraction (GO:0070252)3.86936441
66striated muscle contraction (GO:0006941)3.86301991
67urea cycle (GO:0000050)3.86226528
68urea metabolic process (GO:0019627)3.86226528
69NADH metabolic process (GO:0006734)3.85932270
70branched-chain amino acid metabolic process (GO:0009081)3.81835906
71sarcomere organization (GO:0045214)3.81687407
72translational termination (GO:0006415)3.81528779
73organic acid catabolic process (GO:0016054)3.80376750
74carboxylic acid catabolic process (GO:0046395)3.80376750
75myofibril assembly (GO:0030239)3.78984641
76aromatic amino acid family metabolic process (GO:0009072)3.76915517
77high-density lipoprotein particle remodeling (GO:0034375)3.76527743
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74675686
79complement activation, alternative pathway (GO:0006957)3.74377188
80negative regulation of fatty acid biosynthetic process (GO:0045717)3.71943001
81hexose biosynthetic process (GO:0019319)3.68544082
82nitrogen cycle metabolic process (GO:0071941)3.68340647
83outer ear morphogenesis (GO:0042473)3.68099199
84regulation of protein activation cascade (GO:2000257)3.66773315
85oxaloacetate metabolic process (GO:0006107)3.66484714
86succinate metabolic process (GO:0006105)3.65719383
87negative regulation of fibrinolysis (GO:0051918)3.63629771
88valine metabolic process (GO:0006573)3.61879614
89tricarboxylic acid metabolic process (GO:0072350)3.60792557
90acylglycerol homeostasis (GO:0055090)3.60682946
91triglyceride homeostasis (GO:0070328)3.60682946
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.60223529
93bile acid metabolic process (GO:0008206)3.57979359
94cardiac myofibril assembly (GO:0055003)3.57486855
95serine family amino acid biosynthetic process (GO:0009070)3.55164904
96outflow tract septum morphogenesis (GO:0003148)3.54314540
97biotin metabolic process (GO:0006768)3.52389040
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.51684636
99translational elongation (GO:0006414)3.50686436
100respiratory electron transport chain (GO:0022904)3.49856549
101regulation of secondary heart field cardioblast proliferation (GO:0003266)3.49647375
102regulation of cardioblast proliferation (GO:0003264)3.49647375
103flavonoid metabolic process (GO:0009812)3.49644678
104regulation of skeletal muscle contraction (GO:0014819)3.49170710
105pyrimidine nucleoside catabolic process (GO:0046135)3.49138914
106coenzyme catabolic process (GO:0009109)3.48675372
107regulation of complement activation (GO:0030449)3.46652138
108monosaccharide biosynthetic process (GO:0046364)3.46185053
109tyrosine metabolic process (GO:0006570)3.45445258
110carnitine transport (GO:0015879)3.41238096
111amino-acid betaine transport (GO:0015838)3.41238096
112regulation of cholesterol esterification (GO:0010872)3.40893052
113positive regulation of myotube differentiation (GO:0010831)3.40702142
114skeletal muscle fiber development (GO:0048741)3.40587307
115electron transport chain (GO:0022900)3.40494523
116regulation of fatty acid oxidation (GO:0046320)3.38141391
117regulation of fibrinolysis (GO:0051917)3.36655079
118energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36171353
119ATP synthesis coupled proton transport (GO:0015986)3.36171353
120dicarboxylic acid metabolic process (GO:0043648)3.35627016
121carnitine transmembrane transport (GO:1902603)3.35206112
122* oxidative phosphorylation (GO:0006119)3.34474109
123thyroid gland development (GO:0030878)3.33346583
124fatty acid homeostasis (GO:0055089)3.32518491
125regulation of sequestering of triglyceride (GO:0010889)3.31804293
126negative regulation of sterol transport (GO:0032372)3.31595275
127negative regulation of cholesterol transport (GO:0032375)3.31595275
128regulation of cholesterol homeostasis (GO:2000188)3.31056691
129cellular glucuronidation (GO:0052695)3.29759397
130peptidyl-glutamic acid carboxylation (GO:0017187)3.28664050
131protein carboxylation (GO:0018214)3.28664050
132benzene-containing compound metabolic process (GO:0042537)3.28357596
133response to mercury ion (GO:0046689)3.27756274
134plasma lipoprotein particle remodeling (GO:0034369)3.27679863
135protein-lipid complex remodeling (GO:0034368)3.27679863
136macromolecular complex remodeling (GO:0034367)3.27679863
137embryonic viscerocranium morphogenesis (GO:0048703)3.26592253
138* ATP biosynthetic process (GO:0006754)3.21548745
139regulation of relaxation of muscle (GO:1901077)3.20235151
140fructose metabolic process (GO:0006000)3.19548924
141protein complex biogenesis (GO:0070271)3.17092393
142regulation of skeletal muscle cell differentiation (GO:2001014)3.15227562
143peptidyl-arginine omega-N-methylation (GO:0035247)3.10834943
144coronary vasculature morphogenesis (GO:0060977)3.04903301
145pentose metabolic process (GO:0019321)3.00880472
146positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.99996540
147viral life cycle (GO:0019058)2.99607577
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98710785
149amyloid precursor protein metabolic process (GO:0042982)2.98030863
150muscle tissue morphogenesis (GO:0060415)2.98010263
151histone arginine methylation (GO:0034969)2.97195771
152regulation of oxidative phosphorylation (GO:0002082)2.96200919
153* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94975738
154protein targeting to ER (GO:0045047)2.94783239
155nucleotide salvage (GO:0043173)2.90631828
156response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.90480495
157negative regulation of myotube differentiation (GO:0010832)2.88696588
158cotranslational protein targeting to membrane (GO:0006613)2.88320563
159* purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87987128
160regulation of cellular respiration (GO:0043457)2.87831324
161response to muscle activity (GO:0014850)2.87596414
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87373116
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.87373116
164NADH dehydrogenase complex assembly (GO:0010257)2.87373116
165regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86457181
166myotube cell development (GO:0014904)2.85611695
167cellular protein complex disassembly (GO:0043624)2.84614843
168mitochondrial respiratory chain complex assembly (GO:0033108)2.84195600
169establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82160683
170protein localization to endoplasmic reticulum (GO:0070972)2.81327574
171mitochondrial transport (GO:0006839)2.81238930
172galactose catabolic process (GO:0019388)2.80885104
173nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79971395
174regulation of cardioblast differentiation (GO:0051890)2.79779166
175heart trabecula formation (GO:0060347)2.77635457
176proline biosynthetic process (GO:0006561)2.77321495
177* ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76475412
178pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75285987
179ubiquinone biosynthetic process (GO:0006744)2.74601646
180maturation of SSU-rRNA (GO:0030490)2.73928894
181pharyngeal system development (GO:0060037)2.73384260
182cranial nerve morphogenesis (GO:0021602)2.71679788
183peptidyl-histidine modification (GO:0018202)2.71307694
184regulation of actin filament-based movement (GO:1903115)2.70113921
185protein targeting to mitochondrion (GO:0006626)2.69981934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.05810464
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.86569191
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.10743511
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.58228976
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.51750906
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.00975149
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92377095
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.60730443
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43839797
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.41721313
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.17793290
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.00768835
13NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.53766434
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48245899
15VDR_21846776_ChIP-Seq_THP-1_Human2.43651032
16ZNF263_19887448_ChIP-Seq_K562_Human2.37519364
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36592331
18STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15580946
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07391527
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00861276
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00017669
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93625199
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89835015
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85766146
25XRN2_22483619_ChIP-Seq_HELA_Human1.79138748
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.77332599
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.65286944
28MYC_22102868_ChIP-Seq_BL_Human1.64601185
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59129305
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57317848
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53667679
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53610778
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53075569
34CTCF_18555785_ChIP-Seq_MESCs_Mouse1.52622042
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52522954
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52461686
37CTCF_26484167_Chip-Seq_Bcells_Mouse1.50427624
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50045015
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48566514
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45669324
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45555248
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45518741
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43772767
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42540147
45KDM2B_26808549_Chip-Seq_DND41_Human1.40447598
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38811085
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.37892972
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37071811
49CLOCK_20551151_ChIP-Seq_293T_Human1.36412460
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36407925
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35278126
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.33418774
53LXR_22292898_ChIP-Seq_THP-1_Human1.28947422
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28332151
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26537157
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26372694
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25499962
58SMC4_20622854_ChIP-Seq_HELA_Human1.24290728
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23500047
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22971630
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22769966
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21758424
63KDM2B_26808549_Chip-Seq_K562_Human1.21531040
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20800065
65SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18738332
66SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16360542
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14814917
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14472644
69MAF_26560356_Chip-Seq_TH2_Human1.14132194
70* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13780229
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13750319
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11445891
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10114379
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09454410
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08522908
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07335738
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06682389
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05977736
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05925650
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05820610
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05770792
82ETS1_21867929_ChIP-Seq_TH2_Mouse1.05457503
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05352862
84CTCF_20526341_ChIP-Seq_ESCs_Human1.05342412
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.04699528
86* TET1_21451524_ChIP-Seq_MESCs_Mouse1.04512472
87P68_20966046_ChIP-Seq_HELA_Human1.04193733
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03948808
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03394681
90RACK7_27058665_Chip-Seq_MCF-7_Human1.03365142
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03026033
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01489528
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01489528
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01489528
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.00201416
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.00201416
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00084340
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99312315
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98771755
100ATF3_27146783_Chip-Seq_COLON_Human0.97131877
101* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96703200
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96331435
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95207773
104MYC_18555785_ChIP-Seq_MESCs_Mouse0.94321468
105BCOR_27268052_Chip-Seq_Bcells_Human0.93976215
106NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92852517
107NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92693801
108MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91958634
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91876873
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91815630
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.90535401
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89395445
113E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89276450
114POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88689745
115BCL6_27268052_Chip-Seq_Bcells_Human0.88569187
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88154836
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83989084
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83969634
119CTCF_27219007_Chip-Seq_Bcells_Human0.82779212
120E2F1_20622854_ChIP-Seq_HELA_Human0.82022119
121SA1_27219007_Chip-Seq_Bcells_Human0.80067167
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.78949038
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.78562894
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.78271194
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77863956
126CREB1_26743006_Chip-Seq_LNCaP_Human0.77403319
127PHF8_20622854_ChIP-Seq_HELA_Human0.77350974
128SOX2_18692474_ChIP-Seq_MESCs_Mouse0.77327826
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76343039
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73406722
131CTCF_21964334_Chip-Seq_Bcells_Human0.73129598
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.73056008
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.73007096
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72657396
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.72326827
136GATA1_22025678_ChIP-Seq_K562_Human0.71318006
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70401674
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69801935
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.68963200
140YY1_21170310_ChIP-Seq_MESCs_Mouse0.68752126
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.68588564
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.68492838
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.68362204
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.67783995
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66016362
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.65435561
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65262567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.02212805
2MP0005360_urolithiasis5.70033782
3MP0005085_abnormal_gallbladder_physiolo4.97286531
4MP0003806_abnormal_nucleotide_metabolis4.60104654
5MP0005365_abnormal_bile_salt4.49884907
6MP0008875_abnormal_xenobiotic_pharmacok3.67492790
7MP0003646_muscle_fatigue3.62482650
8MP0002837_dystrophic_cardiac_calcinosis3.55338956
9MP0002234_abnormal_pharynx_morphology3.35541068
10MP0000678_abnormal_parathyroid_gland3.11071333
11MP0003252_abnormal_bile_duct2.99355218
12MP0009840_abnormal_foam_cell2.84262924
13MP0005332_abnormal_amino_acid2.78848748
14MP0002249_abnormal_larynx_morphology2.75723698
15MP0010329_abnormal_lipoprotein_level2.60148257
16MP0005083_abnormal_biliary_tract2.52352243
17MP0003195_calcinosis2.50085220
18MP0006036_abnormal_mitochondrial_physio2.47087379
19MP0004084_abnormal_cardiac_muscle2.34276973
20MP0000733_abnormal_muscle_development2.16201515
21MP0005330_cardiomyopathy2.14795448
22MP0004510_myositis2.13543231
23MP0000751_myopathy2.08126666
24MP0004036_abnormal_muscle_relaxation2.02530608
25MP0010030_abnormal_orbit_morphology2.01333564
26MP0004215_abnormal_myocardial_fiber1.98151762
27MP0004858_abnormal_nervous_system1.96197153
28MP0002163_abnormal_gland_morphology1.94958101
29MP0004130_abnormal_muscle_cell1.94222730
30MP0001666_abnormal_nutrient_absorption1.91425636
31MP0005319_abnormal_enzyme/_coenzyme1.87597339
32MP0003191_abnormal_cellular_cholesterol1.83510452
33MP0004019_abnormal_vitamin_homeostasis1.80727084
34MP0002118_abnormal_lipid_homeostasis1.77653392
35MP0005670_abnormal_white_adipose1.77489523
36MP0002269_muscular_atrophy1.70272089
37MP0000749_muscle_degeneration1.69251358
38MP0000609_abnormal_liver_physiology1.67385856
39MP0003879_abnormal_hair_cell1.65868085
40MP0005623_abnormal_meninges_morphology1.64191666
41MP0006035_abnormal_mitochondrial_morpho1.62961606
42MP0004043_abnormal_pH_regulation1.56603320
43MP0005584_abnormal_enzyme/coenzyme_acti1.56524742
44MP0003186_abnormal_redox_activity1.55490090
45MP0009643_abnormal_urine_homeostasis1.52503954
46MP0004087_abnormal_muscle_fiber1.52491069
47MP0005666_abnormal_adipose_tissue1.51761884
48MP0005266_abnormal_metabolism1.47432308
49MP0005058_abnormal_lysosome_morphology1.44242847
50MP0001346_abnormal_lacrimal_gland1.37244493
51MP0009333_abnormal_splenocyte_physiolog1.36962699
52MP0001764_abnormal_homeostasis1.35957092
53MP0002138_abnormal_hepatobiliary_system1.35849821
54MP0000049_abnormal_middle_ear1.35049381
55MP0003137_abnormal_impulse_conducting1.32397229
56MP0000750_abnormal_muscle_regeneration1.31607462
57MP0000681_abnormal_thyroid_gland1.27246619
58MP0008775_abnormal_heart_ventricle1.26554593
59MP0004233_abnormal_muscle_weight1.24799068
60MP0005451_abnormal_body_composition1.24427506
61MP0003705_abnormal_hypodermis_morpholog1.23217925
62MP0000747_muscle_weakness1.23078077
63MP0002972_abnormal_cardiac_muscle1.22809982
64MP0009379_abnormal_foot_pigmentation1.22760215
65MP0005385_cardiovascular_system_phenoty1.22752558
66MP0001544_abnormal_cardiovascular_syste1.22752558
67MP0010630_abnormal_cardiac_muscle1.22017088
68MP0005166_decreased_susceptibility_to1.20093944
69MP0000003_abnormal_adipose_tissue1.19184803
70MP0005620_abnormal_muscle_contractility1.17985604
71MP0002332_abnormal_exercise_endurance1.15708883
72MP0002132_abnormal_respiratory_system1.14946814
73MP0002822_catalepsy1.12917965
74MP0006138_congestive_heart_failure1.09167071
75MP0002877_abnormal_melanocyte_morpholog1.08919337
76MP0002106_abnormal_muscle_physiology1.07376872
77MP0000343_altered_response_to1.05955871
78MP0004185_abnormal_adipocyte_glucose1.00812629
79MP0003221_abnormal_cardiomyocyte_apopto0.99895889
80MP0005636_abnormal_mineral_homeostasis0.99101416
81MP0003283_abnormal_digestive_organ0.98402715
82MP0003075_altered_response_to0.96989089
83MP0002078_abnormal_glucose_homeostasis0.96655458
84MP0005376_homeostasis/metabolism_phenot0.95905421
85MP0003868_abnormal_feces_composition0.95014166
86MP0002971_abnormal_brown_adipose0.92617668
87MP0003656_abnormal_erythrocyte_physiolo0.92585790
88MP0000598_abnormal_liver_morphology0.90737667
89MP0005379_endocrine/exocrine_gland_phen0.89516214
90MP0005535_abnormal_body_temperature0.84722793
91MP0000759_abnormal_skeletal_muscle0.83008318
92MP0004145_abnormal_muscle_electrophysio0.82948319
93MP0004484_altered_response_of0.82703210
94MP0001756_abnormal_urination0.81337060
95MP0005369_muscle_phenotype0.80281458
96MP0008260_abnormal_autophagy0.79153073
97MP0005647_abnormal_sex_gland0.77765982
98MP0005375_adipose_tissue_phenotype0.75846424
99MP0001873_stomach_inflammation0.74924113
100MP0004085_abnormal_heartbeat0.73889489
101MP0000013_abnormal_adipose_tissue0.72194046
102MP0002127_abnormal_cardiovascular_syste0.71382980
103MP0008932_abnormal_embryonic_tissue0.71004653
104MP0009642_abnormal_blood_homeostasis0.70403639
105MP0003011_delayed_dark_adaptation0.66686314
106MP0000230_abnormal_systemic_arterial0.66404789
107MP0005334_abnormal_fat_pad0.64569456
108MP0005165_increased_susceptibility_to0.64406203
109MP0009250_abnormal_appendicular_skeleto0.63753755
110MP0008872_abnormal_physiological_respon0.61544033
111MP0003718_maternal_effect0.58137749
112MP0003303_peritoneal_inflammation0.57518680
113MP0003123_paternal_imprinting0.57397397
114MP0003329_amyloid_beta_deposits0.56537638
115MP0003453_abnormal_keratinocyte_physiol0.56535776
116MP0001765_abnormal_ion_homeostasis0.56359850
117MP0001661_extended_life_span0.55619771
118MP0009763_increased_sensitivity_to0.55417154
119MP0000762_abnormal_tongue_morphology0.55370734
120MP0005377_hearing/vestibular/ear_phenot0.54356199
121MP0003878_abnormal_ear_physiology0.54356199
122MP0001879_abnormal_lymphatic_vessel0.52289503
123MP0000604_amyloidosis0.51661458
124MP0002277_abnormal_respiratory_mucosa0.51658530
125MP0003567_abnormal_fetal_cardiomyocyte0.51644490
126MP0003953_abnormal_hormone_level0.51154951
127MP0002108_abnormal_muscle_morphology0.50514788
128MP0002970_abnormal_white_adipose0.50495915
129MP0004270_analgesia0.50491153
130MP0002796_impaired_skin_barrier0.50338104
131MP0003693_abnormal_embryo_hatching0.49792915
132MP0005501_abnormal_skin_physiology0.49672583
133MP0002136_abnormal_kidney_physiology0.49192419
134MP0005167_abnormal_blood-brain_barrier0.48613365
135MP0001188_hyperpigmentation0.46409881
136MP0001270_distended_abdomen0.46395507
137MP0005448_abnormal_energy_balance0.46254547
138MP0008961_abnormal_basal_metabolism0.44678028
139MP0008874_decreased_physiological_sensi0.44018757
140MP0008469_abnormal_protein_level0.43985444
141MP0001502_abnormal_circadian_rhythm0.42889229

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.49953737
2Congenital malformation of the right heart (HP:0011723)5.48118297
3Double outlet right ventricle (HP:0001719)5.48118297
4Nemaline bodies (HP:0003798)5.22244728
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.17973096
6Hyperglycinuria (HP:0003108)4.98767003
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.69736600
8Hyperammonemia (HP:0001987)4.60195126
9Intrahepatic cholestasis (HP:0001406)4.53511074
10Hypoglycemic coma (HP:0001325)4.46810020
11Abnormality of glycine metabolism (HP:0010895)4.39690292
12Abnormality of serine family amino acid metabolism (HP:0010894)4.39690292
13Ketosis (HP:0001946)4.38979564
14Myopathic facies (HP:0002058)4.29402926
15Abnormality of monocarboxylic acid metabolism (HP:0010996)4.23140368
16Hyperglycinemia (HP:0002154)4.20376459
17Type 1 muscle fiber predominance (HP:0003803)4.13316458
18Myoglobinuria (HP:0002913)4.12978635
19Xanthomatosis (HP:0000991)4.11349832
20Dicarboxylic aciduria (HP:0003215)4.05201977
21Abnormality of dicarboxylic acid metabolism (HP:0010995)4.05201977
22Abnormality of fatty-acid metabolism (HP:0004359)4.03381972
23Deep venous thrombosis (HP:0002625)4.01267412
24Ketoacidosis (HP:0001993)4.00626663
25Cerebral edema (HP:0002181)3.83318801
26Hypobetalipoproteinemia (HP:0003563)3.79925809
27Subaortic stenosis (HP:0001682)3.79514428
28Abnormality of the left ventricular outflow tract (HP:0011103)3.79514428
29Hypoplastic left heart (HP:0004383)3.64773318
30Truncus arteriosus (HP:0001660)3.56155254
31Hyperlipoproteinemia (HP:0010980)3.51203338
32Exercise-induced myalgia (HP:0003738)3.49962489
33Sudden death (HP:0001699)3.49371129
34Hepatic necrosis (HP:0002605)3.40875474
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.40332348
36Acute encephalopathy (HP:0006846)3.39006295
37Lethargy (HP:0001254)3.36931837
38Hypolipoproteinemia (HP:0010981)3.35708403
39Hypoalphalipoproteinemia (HP:0003233)3.35185713
40Rhabdomyolysis (HP:0003201)3.33804913
41Exercise-induced muscle cramps (HP:0003710)3.25219060
42Gout (HP:0001997)3.23302023
43Distal lower limb muscle weakness (HP:0009053)3.23056552
44EMG: myopathic abnormalities (HP:0003458)3.22274666
45Centrally nucleated skeletal muscle fibers (HP:0003687)3.17891677
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17332818
47Hyperthyroidism (HP:0000836)3.15656995
48Distal arthrogryposis (HP:0005684)3.12528971
49Prolonged partial thromboplastin time (HP:0003645)3.10465061
50Metabolic acidosis (HP:0001942)3.10299381
51Hypoplastic heart (HP:0001961)3.07796744
52Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03923370
53Abnormal mitochondria in muscle tissue (HP:0008316)2.99017859
54Exercise intolerance (HP:0003546)2.96405849
55Ventricular tachycardia (HP:0004756)2.95468431
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.94956115
57Progressive muscle weakness (HP:0003323)2.94747431
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93659387
59Periauricular skin pits (HP:0100277)2.91196136
60Preauricular pit (HP:0004467)2.91196136
61Increased muscle lipid content (HP:0009058)2.89616920
62Palpitations (HP:0001962)2.89594201
63Acute necrotizing encephalopathy (HP:0006965)2.88874051
64Generalized aminoaciduria (HP:0002909)2.86876678
65Abnormality of serum amino acid levels (HP:0003112)2.79632137
66Abnormality of skeletal muscle fiber size (HP:0012084)2.77603773
67Round ear (HP:0100830)2.76597826
68Transposition of the great arteries (HP:0001669)2.74045844
69Abnormal connection of the cardiac segments (HP:0011545)2.74045844
70Abnormal ventriculo-arterial connection (HP:0011563)2.74045844
71Delayed CNS myelination (HP:0002188)2.73828014
72Hepatocellular necrosis (HP:0001404)2.72206709
73Abnormality of methionine metabolism (HP:0010901)2.70954261
74Lactic acidosis (HP:0003128)2.69140710
75Vomiting (HP:0002013)2.69057135
76Complement deficiency (HP:0004431)2.68491355
77Abnormality of the aortic arch (HP:0012303)2.67874720
78Unilateral renal agenesis (HP:0000122)2.65161712
79Calf muscle hypertrophy (HP:0008981)2.57291084
80Epidermoid cyst (HP:0200040)2.56317434
81Increased variability in muscle fiber diameter (HP:0003557)2.55705583
82Proximal tubulopathy (HP:0000114)2.54272105
83Abnormality of purine metabolism (HP:0004352)2.50456094
84Right ventricular cardiomyopathy (HP:0011663)2.50158951
85Increased CSF lactate (HP:0002490)2.47863376
86Mitochondrial inheritance (HP:0001427)2.47026899
87Abnormality of nucleobase metabolism (HP:0010932)2.46508916
88Increased intramyocellular lipid droplets (HP:0012240)2.46505126
89Nausea (HP:0002018)2.45372304
90Neck muscle weakness (HP:0000467)2.44536714
91Abnormality of the calf musculature (HP:0001430)2.44349758
92Hyperuricemia (HP:0002149)2.41123538
93Increased purine levels (HP:0004368)2.41123538
94Hyporeflexia of lower limbs (HP:0002600)2.39477309
95Ragged-red muscle fibers (HP:0003200)2.39287789
96Hyperinsulinemic hypoglycemia (HP:0000825)2.39074835
97Abnormality of pyrimidine metabolism (HP:0004353)2.38614561
98Rimmed vacuoles (HP:0003805)2.37139546
99Muscle hypertrophy of the lower extremities (HP:0008968)2.35859812
100Increased connective tissue (HP:0009025)2.35726393
101Late onset (HP:0003584)2.35403157
102Cholelithiasis (HP:0001081)2.34845050
103Progressive macrocephaly (HP:0004481)2.34456674
104Hyperbilirubinemia (HP:0002904)2.33132445
105Bundle branch block (HP:0011710)2.32807290
106Asymmetric septal hypertrophy (HP:0001670)2.31705808
107Muscle fiber splitting (HP:0003555)2.31305187
108Atrioventricular block (HP:0001678)2.30401945
109Heart block (HP:0012722)2.28624519
110Neonatal onset (HP:0003623)2.28198512
111Areflexia of lower limbs (HP:0002522)2.26487192
112Fat malabsorption (HP:0002630)2.25710424
113Stridor (HP:0010307)2.25346585
114Methylmalonic aciduria (HP:0012120)2.22450754
115Abnormality of the tricuspid valve (HP:0001702)2.22304644
116Syncope (HP:0001279)2.20622272
117Abnormal gallbladder morphology (HP:0012437)2.19562905
118Ulnar deviation of the wrist (HP:0003049)2.18755255
119Supraventricular tachycardia (HP:0004755)2.18533037
120Calcaneovalgus deformity (HP:0001848)2.17784428
121Absent phalangeal crease (HP:0006109)2.16660748
122Renal Fanconi syndrome (HP:0001994)2.16227537
123Abnormality of proline metabolism (HP:0010907)2.16203302
124Hydroxyprolinuria (HP:0003080)2.16203302
125Abnormality of urine glucose concentration (HP:0011016)2.15332971
126Glycosuria (HP:0003076)2.15332971
127Joint hemorrhage (HP:0005261)2.14918163
128Muscle stiffness (HP:0003552)2.13771439
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12039046
130Lipoatrophy (HP:0100578)2.10753333
131Abnormal cartilage morphology (HP:0002763)2.10545824
132Respiratory failure (HP:0002878)2.10162199
133Supraventricular arrhythmia (HP:0005115)2.09838678
134Skin nodule (HP:0200036)2.09572172
135Abnormal atrioventricular conduction (HP:0005150)2.08245581
136Hypertensive crisis (HP:0100735)2.06407739
137Difficulty running (HP:0009046)2.03388802
138Dilated cardiomyopathy (HP:0001644)2.02559643
139Hypoglycemic seizures (HP:0002173)2.02448846
140Hypercholesterolemia (HP:0003124)2.01633034
141Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00856727
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00856727
143Abnormality of glycolysis (HP:0004366)2.00663192
144Achilles tendon contracture (HP:0001771)2.00344176
145Abnormality of the common coagulation pathway (HP:0010990)1.99344110
146Ventricular arrhythmia (HP:0004308)1.97860293
147Atrial fibrillation (HP:0005110)1.97590556
148Microretrognathia (HP:0000308)1.96593963
149Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93253802
150Skin pits (HP:0100276)1.92179831
151Rectal prolapse (HP:0002035)1.89884837
152Abnormality of the parathyroid morphology (HP:0011766)1.89623172
153Abnormality of the Achilles tendon (HP:0005109)1.89139296
154Increased serum lactate (HP:0002151)1.89077978
155Increased serum pyruvate (HP:0003542)1.86947482
156Neoplasm of head and neck (HP:0012288)1.86354142
157Esophageal neoplasm (HP:0100751)1.86354142
158Abnormal EKG (HP:0003115)1.85546547
159Lipid accumulation in hepatocytes (HP:0006561)1.83812808
160EMG: neuropathic changes (HP:0003445)1.81799568
161Deformed tarsal bones (HP:0008119)1.80587454
162Delusions (HP:0000746)1.78448557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.70138395
2SMG15.26657683
3VRK24.79885476
4NEK13.63207925
5PKN23.13494052
6TAF13.07132206
7PDK42.98481037
8PDK32.98481037
9PRKD32.79548491
10TTN2.78210980
11TRIB32.70988815
12STK38L2.67315498
13ERN12.61749575
14PHKG12.60626393
15PHKG22.60626393
16LMTK22.50839220
17PINK12.42203392
18IRAK32.36515721
19OBSCN2.36389002
20MAP3K71.98092505
21MYLK1.90175694
22PIK3CA1.85097282
23PRPF4B1.82466548
24PDK21.79702038
25STK161.76701474
26SIK11.75627921
27DMPK1.72038289
28ARAF1.56996712
29TAOK21.55943193
30MAPKAPK31.55020289
31FLT31.46947778
32EEF2K1.38391444
33STK381.35782987
34FGFR41.31610897
35WNK41.28904071
36GRK51.27882908
37MAPKAPK51.27669095
38MAP3K101.22366481
39DAPK11.19928141
40MAPK111.15574268
41CSNK1G31.14142142
42KDR1.07738740
43MAPK121.06223102
44VRK11.06095095
45ICK1.04751218
46TIE11.01221404
47GRK61.00486799
48MAP2K41.00159096
49MAP3K110.99723763
50TAOK30.98906274
51EPHA20.97914571
52MAP3K10.97881442
53CSNK1A1L0.94951195
54PIM20.91469378
55PRKAA10.90859390
56RIPK10.90334477
57MAP2K20.88094633
58MST1R0.83636881
59PRKAA20.82233797
60PDPK10.78185962
61IRAK20.77997922
62MAP2K30.76679090
63DAPK30.76603817
64CDK40.75257646
65AKT20.74165833
66NME20.73683425
67TAOK10.73052380
68LIMK10.72886695
69KSR20.72354873
70TESK10.71542417
71ILK0.71028630
72BUB10.70974658
73AURKA0.70884951
74INSRR0.69977556
75TTK0.69927135
76HIPK20.68048264
77CSNK1G10.65878680
78PDK10.65728267
79TBK10.65054749
80CSNK1G20.64868245
81PRKACG0.62553994
82ERBB40.62462467
83CAMK2G0.62003496
84NME10.60232617
85ABL20.59670019
86RPS6KB20.59134194
87MAP2K10.59098610
88DAPK20.58371988
89CDK90.58227165
90STK110.56967713
91WNK30.56681060
92STK40.56595270
93MAP2K60.55905744
94CAMK2D0.55209243
95PRKD10.53081919
96RPS6KL10.52878649
97RPS6KC10.52878649
98PAK30.52548551
99TLK10.51033546
100ZAK0.50250593
101MUSK0.48807951
102CDC42BPA0.48083493
103RAF10.48070839
104MAP3K50.46993790
105CAMK40.46753351
106IKBKB0.46732655
107RIPK40.46488341
108TYK20.46132431
109BRSK10.45985772
110CHEK20.45501718
111EPHA40.45472168
112AKT30.45182742
113CAMK2B0.45123650
114MELK0.43734205
115MAPK40.43669804
116CCNB10.43171033
117CAMK10.42962916
118PTK60.42598918
119MTOR0.42280955
120PIK3CG0.41658897
121LRRK20.40270633
122DYRK30.39032295
123PRKACB0.38637031
124RPS6KA60.37912460
125PRKACA0.37601506
126CDK70.36100178
127IRAK40.36029078
128MAP3K30.36015260
129CAMK1D0.35903580
130CDK11A0.35692780
131NUAK10.32801160
132WEE10.32323435
133LATS20.32195579
134MAP3K80.31410655
135CDK150.31133227
136PRKG20.29802200
137PAK10.29490369
138GRK70.29028147
139RPS6KA50.28931277
140PRKCZ0.28848274
141JAK20.28767389
142ROCK10.28727075
143MAPK70.24902922
144DYRK1B0.24407371
145STK240.23833854
146MET0.21982046
147RPS6KA10.21497007
148BRAF0.20018988
149SGK30.19925010
150MAP3K90.19860255

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.75528306
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.60920400
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.18353804
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06213744
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.05131508
6Fatty acid degradation_Homo sapiens_hsa000713.04091782
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.01377061
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.95659978
9Propanoate metabolism_Homo sapiens_hsa006402.90978044
10Nitrogen metabolism_Homo sapiens_hsa009102.88607280
11Arginine biosynthesis_Homo sapiens_hsa002202.61527455
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54570416
13Butanoate metabolism_Homo sapiens_hsa006502.47206071
14Tryptophan metabolism_Homo sapiens_hsa003802.27913376
15Carbon metabolism_Homo sapiens_hsa012002.25932070
16Fatty acid metabolism_Homo sapiens_hsa012122.20726925
17Pyruvate metabolism_Homo sapiens_hsa006202.20694702
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08720722
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93248740
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90174940
21Peroxisome_Homo sapiens_hsa041461.83937083
22PPAR signaling pathway_Homo sapiens_hsa033201.81422739
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80635382
24Biosynthesis of amino acids_Homo sapiens_hsa012301.75305276
25Oxidative phosphorylation_Homo sapiens_hsa001901.67165684
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63317495
27beta-Alanine metabolism_Homo sapiens_hsa004101.61173673
28Parkinsons disease_Homo sapiens_hsa050121.57692394
29Sulfur metabolism_Homo sapiens_hsa009201.44838065
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.41583073
31Complement and coagulation cascades_Homo sapiens_hsa046101.41446715
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40698747
33Tyrosine metabolism_Homo sapiens_hsa003501.36164396
34Phenylalanine metabolism_Homo sapiens_hsa003601.34094055
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33094723
36Chemical carcinogenesis_Homo sapiens_hsa052041.31652955
37Cardiac muscle contraction_Homo sapiens_hsa042601.30409656
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29445574
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28106597
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27945481
41Bile secretion_Homo sapiens_hsa049761.27939792
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27687393
43Fatty acid elongation_Homo sapiens_hsa000621.27102089
44Selenocompound metabolism_Homo sapiens_hsa004501.27065948
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.26191056
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21175581
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.19833622
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19007982
49Arginine and proline metabolism_Homo sapiens_hsa003301.17010255
50Folate biosynthesis_Homo sapiens_hsa007901.13612867
51Fat digestion and absorption_Homo sapiens_hsa049751.12452536
52Histidine metabolism_Homo sapiens_hsa003401.12003335
53Sulfur relay system_Homo sapiens_hsa041221.09803407
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.07290573
55Alzheimers disease_Homo sapiens_hsa050101.05093724
56Retinol metabolism_Homo sapiens_hsa008300.95992201
57Huntingtons disease_Homo sapiens_hsa050160.91659045
58Fructose and mannose metabolism_Homo sapiens_hsa000510.89433828
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89244948
60Caffeine metabolism_Homo sapiens_hsa002320.87791676
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85940563
62Pentose phosphate pathway_Homo sapiens_hsa000300.82913243
63Glutathione metabolism_Homo sapiens_hsa004800.76214699
64Galactose metabolism_Homo sapiens_hsa000520.72802372
65Lysine degradation_Homo sapiens_hsa003100.72174837
66Glycerolipid metabolism_Homo sapiens_hsa005610.71538608
67Bladder cancer_Homo sapiens_hsa052190.71378404
68Fatty acid biosynthesis_Homo sapiens_hsa000610.65851733
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65554957
70Metabolic pathways_Homo sapiens_hsa011000.65377340
71DNA replication_Homo sapiens_hsa030300.63947143
72ABC transporters_Homo sapiens_hsa020100.62783466
73One carbon pool by folate_Homo sapiens_hsa006700.62021770
74Staphylococcus aureus infection_Homo sapiens_hsa051500.60870471
75Other glycan degradation_Homo sapiens_hsa005110.60452580
76Base excision repair_Homo sapiens_hsa034100.56945497
77Systemic lupus erythematosus_Homo sapiens_hsa053220.53983421
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52796889
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.51692818
80Synaptic vesicle cycle_Homo sapiens_hsa047210.47248501
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44255620
82Notch signaling pathway_Homo sapiens_hsa043300.43878542
83Glucagon signaling pathway_Homo sapiens_hsa049220.42500821
84Vitamin digestion and absorption_Homo sapiens_hsa049770.41721873
85Vitamin B6 metabolism_Homo sapiens_hsa007500.39455841
86Purine metabolism_Homo sapiens_hsa002300.38735158
87Insulin resistance_Homo sapiens_hsa049310.37343468
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.35020528
89Vibrio cholerae infection_Homo sapiens_hsa051100.32780493
90VEGF signaling pathway_Homo sapiens_hsa043700.30165037
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26834651
92Collecting duct acid secretion_Homo sapiens_hsa049660.26061376
93AMPK signaling pathway_Homo sapiens_hsa041520.25719111
94Basal cell carcinoma_Homo sapiens_hsa052170.24562286
95Non-small cell lung cancer_Homo sapiens_hsa052230.24355821
96Dilated cardiomyopathy_Homo sapiens_hsa054140.23897702
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22246066
98Insulin signaling pathway_Homo sapiens_hsa049100.22125994
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21406480
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19645383
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.19285811
102B cell receptor signaling pathway_Homo sapiens_hsa046620.18878026
103Linoleic acid metabolism_Homo sapiens_hsa005910.17255449
104Proteasome_Homo sapiens_hsa030500.14574357
105Glioma_Homo sapiens_hsa052140.13218618
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13173257
107RNA polymerase_Homo sapiens_hsa030200.12490060
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.12405476
109Steroid biosynthesis_Homo sapiens_hsa001000.10480167
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.08480245
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07194114
112Prion diseases_Homo sapiens_hsa050200.05427396
113mTOR signaling pathway_Homo sapiens_hsa041500.05365365
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05183208
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.03912903
116Viral myocarditis_Homo sapiens_hsa054160.03513494
117Calcium signaling pathway_Homo sapiens_hsa040200.02375741
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1360485
119HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1302589
120Circadian rhythm_Homo sapiens_hsa04710-0.1279914
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1082574
122Pyrimidine metabolism_Homo sapiens_hsa00240-0.0858646
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0641112
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0252570
125Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0195178
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0039454

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