CHCHD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.46872684
2ATP synthesis coupled proton transport (GO:0015986)7.04174351
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.04174351
4respiratory electron transport chain (GO:0022904)5.98725697
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.98568329
6electron transport chain (GO:0022900)5.84295926
7DNA deamination (GO:0045006)5.80175872
8oxidative phosphorylation (GO:0006119)5.48250864
9viral transcription (GO:0019083)4.73056297
10ribosomal small subunit assembly (GO:0000028)4.62555245
11translational termination (GO:0006415)4.62252105
12proteasome assembly (GO:0043248)4.43568067
13ribosomal small subunit biogenesis (GO:0042274)4.40922680
14regulation of mitochondrial translation (GO:0070129)4.31738607
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.27530786
16protein maturation by protein folding (GO:0022417)4.23421604
17translational elongation (GO:0006414)4.23300228
18cotranslational protein targeting to membrane (GO:0006613)4.18790301
19protein targeting to ER (GO:0045047)4.17723596
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.08312280
21protein localization to endoplasmic reticulum (GO:0070972)4.02628131
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.01498529
23ATP biosynthetic process (GO:0006754)3.97548442
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95127360
25pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.93500461
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.93330118
27ribosomal large subunit biogenesis (GO:0042273)3.80066504
28purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79345815
29purine nucleoside triphosphate biosynthetic process (GO:0009145)3.78127066
30maturation of SSU-rRNA (GO:0030490)3.77812366
31translational initiation (GO:0006413)3.77521678
32telomere maintenance via semi-conservative replication (GO:0032201)3.77478264
33DNA strand elongation involved in DNA replication (GO:0006271)3.73438724
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72699445
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.72699445
36NADH dehydrogenase complex assembly (GO:0010257)3.72699445
37translation (GO:0006412)3.69559653
38viral life cycle (GO:0019058)3.68616522
39chaperone-mediated protein transport (GO:0072321)3.66324298
40DNA strand elongation (GO:0022616)3.63329358
41protein complex biogenesis (GO:0070271)3.62003088
42protein targeting to membrane (GO:0006612)3.61803104
43cellular protein complex disassembly (GO:0043624)3.59824048
44inner mitochondrial membrane organization (GO:0007007)3.57368788
45regulation of cellular amino acid metabolic process (GO:0006521)3.57241469
46mitochondrial respiratory chain complex assembly (GO:0033108)3.57000884
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.56938534
48deoxyribonucleotide biosynthetic process (GO:0009263)3.55833169
49ribonucleoside triphosphate biosynthetic process (GO:0009201)3.53235447
50pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.51711415
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51334991
52establishment of protein localization to mitochondrion (GO:0072655)3.50572516
53tricarboxylic acid cycle (GO:0006099)3.49811195
54protein targeting to mitochondrion (GO:0006626)3.49025226
55GDP-mannose metabolic process (GO:0019673)3.45605825
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42068585
57signal transduction involved in DNA damage checkpoint (GO:0072422)3.38967260
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.37621945
59protein localization to mitochondrion (GO:0070585)3.35659996
60pyrimidine nucleotide catabolic process (GO:0006244)3.33174133
61signal transduction involved in cell cycle checkpoint (GO:0072395)3.32378682
62formation of translation preinitiation complex (GO:0001731)3.32053518
63termination of RNA polymerase III transcription (GO:0006386)3.31717180
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.31717180
65ribosome biogenesis (GO:0042254)3.27910625
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26987236
67quinone biosynthetic process (GO:1901663)3.25802806
68ubiquinone biosynthetic process (GO:0006744)3.25802806
69mitochondrial transport (GO:0006839)3.25372068
70ribonucleoprotein complex biogenesis (GO:0022613)3.23465282
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.22939182
72folic acid metabolic process (GO:0046655)3.22137210
73hydrogen ion transmembrane transport (GO:1902600)3.21851745
74positive regulation of ligase activity (GO:0051351)3.21793087
75guanosine-containing compound biosynthetic process (GO:1901070)3.20866705
76cellular component biogenesis (GO:0044085)3.19044761
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16680385
78negative regulation of ligase activity (GO:0051352)3.16680385
79purine nucleobase biosynthetic process (GO:0009113)3.16475435
80purine nucleoside monophosphate biosynthetic process (GO:0009127)3.15786706
81purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.15786706
82GTP biosynthetic process (GO:0006183)3.15636619
83nucleoside triphosphate biosynthetic process (GO:0009142)3.15461982
84metallo-sulfur cluster assembly (GO:0031163)3.14576358
85iron-sulfur cluster assembly (GO:0016226)3.14576358
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13617181
87nucleobase-containing small molecule interconversion (GO:0015949)3.13583690
88rRNA processing (GO:0006364)3.10579538
89respiratory chain complex IV assembly (GO:0008535)3.09308883
90regulation of cellular respiration (GO:0043457)3.08035818
91NADH metabolic process (GO:0006734)3.07839074
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07119873
93nuclear-transcribed mRNA catabolic process (GO:0000956)3.06944429
94aerobic respiration (GO:0009060)3.05653931
95deoxyribose phosphate biosynthetic process (GO:0046385)3.05127725
962-deoxyribonucleotide biosynthetic process (GO:0009265)3.05127725
97proline biosynthetic process (GO:0006561)3.04948036
98base-excision repair, AP site formation (GO:0006285)3.04078963
99UTP metabolic process (GO:0046051)3.03779121
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03568429
101pseudouridine synthesis (GO:0001522)3.03215107
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03171899
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.03043138
104protein complex disassembly (GO:0043241)3.02964105
105CTP biosynthetic process (GO:0006241)3.02279726
106CTP metabolic process (GO:0046036)3.02279726
107regulation of ubiquitin-protein transferase activity (GO:0051438)3.00007647
108pteridine-containing compound biosynthetic process (GO:0042559)2.99725449
109establishment of integrated proviral latency (GO:0075713)2.97745154
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97485292
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97485292
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97176830
113regulation of oxidative phosphorylation (GO:0002082)2.96550638
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95384280
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95384280
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95384280
117rRNA metabolic process (GO:0016072)2.94412518
118macromolecular complex disassembly (GO:0032984)2.94385290
119nucleoside monophosphate biosynthetic process (GO:0009124)2.94323591
120nucleobase biosynthetic process (GO:0046112)2.94139765
121nucleoside diphosphate biosynthetic process (GO:0009133)2.93846967
122COPI coating of Golgi vesicle (GO:0048205)2.93828624
123protein deneddylation (GO:0000338)2.93224430
124L-methionine salvage (GO:0071267)2.92916494
125L-methionine biosynthetic process (GO:0071265)2.92916494
126amino acid salvage (GO:0043102)2.92916494
127cullin deneddylation (GO:0010388)2.92796252
128ribonucleoside monophosphate biosynthetic process (GO:0009156)2.92534668
129UTP biosynthetic process (GO:0006228)2.90796417
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88238810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.35828227
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20477650
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92002456
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66564298
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.63495815
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63093094
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.30083849
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24789306
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14753369
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08643819
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06463715
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76256820
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73359139
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66922546
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61420025
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58007560
17* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.46288868
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42759689
19E2F7_22180533_ChIP-Seq_HELA_Human2.41149138
20* XRN2_22483619_ChIP-Seq_HELA_Human2.40609018
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34424279
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32848578
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27243716
24DCP1A_22483619_ChIP-Seq_HELA_Human2.24898841
25VDR_23849224_ChIP-Seq_CD4+_Human2.19183450
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13790647
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09382924
28GABP_19822575_ChIP-Seq_HepG2_Human2.04413937
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04327412
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.03930705
31* SRF_21415370_ChIP-Seq_HL-1_Mouse2.01751343
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95195805
33* YY1_21170310_ChIP-Seq_MESCs_Mouse1.93115997
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88537799
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88399010
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83272541
37* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82878822
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77147237
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76730173
40TTF2_22483619_ChIP-Seq_HELA_Human1.76328771
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72521834
42FOXP3_21729870_ChIP-Seq_TREG_Human1.71436261
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.69111651
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65498118
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63563194
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54933867
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53475895
48* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52414230
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51598166
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50496740
51ZNF263_19887448_ChIP-Seq_K562_Human1.48856880
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47835552
53* RXR_22158963_ChIP-Seq_LIVER_Mouse1.45203024
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43617806
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43396030
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41585521
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36503854
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36344436
59* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36157086
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36112337
61* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34813782
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.34479386
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32610268
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28553718
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27222984
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24210076
67VDR_21846776_ChIP-Seq_THP-1_Human1.23519497
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23339759
69AR_21909140_ChIP-Seq_LNCAP_Human1.22702835
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22649367
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21961814
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21278937
73* ELK1_19687146_ChIP-ChIP_HELA_Human1.21192533
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18622595
75* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12917711
76* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12239598
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12078378
78KDM5A_27292631_Chip-Seq_BREAST_Human1.10184815
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09476204
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08429181
81LXR_22292898_ChIP-Seq_THP-1_Human1.07779464
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07149880
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06991216
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06873397
85CIITA_25753668_ChIP-Seq_RAJI_Human1.06806900
86* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06416661
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04129740
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.02158991
89P68_20966046_ChIP-Seq_HELA_Human1.01173130
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00778961
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.98459018
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98365704
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97590861
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.96796870
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96552503
96* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96313713
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.96105558
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96075673
99* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95862647
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95032405
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94404548
102MYC_22102868_ChIP-Seq_BL_Human0.92895796
103MYC_18940864_ChIP-ChIP_HL60_Human0.92289635
104BCL6_27268052_Chip-Seq_Bcells_Human0.91988883
105TFEB_21752829_ChIP-Seq_HELA_Human0.88617402
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88292326
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86363024
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85914467
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85015813
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84836424
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84337231
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84272847
113E2F1_21310950_ChIP-Seq_MCF-7_Human0.81603175
114CTCF_26484167_Chip-Seq_Bcells_Mouse0.80584521
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79161942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.10311262
2MP0003693_abnormal_embryo_hatching3.95631941
3MP0006036_abnormal_mitochondrial_physio3.75869974
4MP0002139_abnormal_hepatobiliary_system3.72134930
5MP0005360_urolithiasis3.43623730
6MP0003186_abnormal_redox_activity3.28152281
7MP0003195_calcinosis2.99242178
8MP0004957_abnormal_blastocyst_morpholog2.94632734
9MP0003646_muscle_fatigue2.89384947
10MP0006035_abnormal_mitochondrial_morpho2.65588039
11MP0005085_abnormal_gallbladder_physiolo2.60520063
12MP0005365_abnormal_bile_salt2.41280877
13MP0005332_abnormal_amino_acid2.40845096
14MP0009379_abnormal_foot_pigmentation2.33716254
15MP0008007_abnormal_cellular_replicative2.31849677
16MP0008875_abnormal_xenobiotic_pharmacok2.27697422
17MP0002163_abnormal_gland_morphology2.20000632
18MP0002837_dystrophic_cardiac_calcinosis2.15486466
19MP0004043_abnormal_pH_regulation2.15417924
20MP0009840_abnormal_foam_cell2.06275631
21MP0005636_abnormal_mineral_homeostasis1.88776269
22MP0005058_abnormal_lysosome_morphology1.82071779
23MP0009643_abnormal_urine_homeostasis1.81891450
24MP0002877_abnormal_melanocyte_morpholog1.80221927
25MP0005330_cardiomyopathy1.75778320
26MP0004215_abnormal_myocardial_fiber1.71483805
27MP0005266_abnormal_metabolism1.70160994
28MP0004233_abnormal_muscle_weight1.68397210
29MP0003718_maternal_effect1.66339507
30MP0008932_abnormal_embryonic_tissue1.61762200
31MP0001764_abnormal_homeostasis1.61409930
32MP0005501_abnormal_skin_physiology1.59731112
33MP0003315_abnormal_perineum_morphology1.58694731
34MP0009333_abnormal_splenocyte_physiolog1.57292052
35MP0003221_abnormal_cardiomyocyte_apopto1.57227261
36MP0005319_abnormal_enzyme/_coenzyme1.53622159
37MP0000750_abnormal_muscle_regeneration1.51962221
38MP0005083_abnormal_biliary_tract1.51493157
39MP0005670_abnormal_white_adipose1.51109282
40MP0003123_paternal_imprinting1.48279588
41MP0004084_abnormal_cardiac_muscle1.45002451
42MP0000350_abnormal_cell_proliferation1.44439609
43MP0004147_increased_porphyrin_level1.44210837
44MP0005377_hearing/vestibular/ear_phenot1.43859799
45MP0003878_abnormal_ear_physiology1.43859799
46MP0001905_abnormal_dopamine_level1.42498961
47MP0000678_abnormal_parathyroid_gland1.41483905
48MP0001881_abnormal_mammary_gland1.40410392
49MP0004019_abnormal_vitamin_homeostasis1.39345740
50MP0001756_abnormal_urination1.38660580
51MP0002132_abnormal_respiratory_system1.37764241
52MP0000358_abnormal_cell_content/1.36009758
53MP0003077_abnormal_cell_cycle1.34898329
54MP0005379_endocrine/exocrine_gland_phen1.32505228
55MP0005084_abnormal_gallbladder_morpholo1.29660468
56MP0008995_early_reproductive_senescence1.28533655
57MP0006276_abnormal_autonomic_nervous1.26744544
58MP0000313_abnormal_cell_death1.26707694
59MP0010329_abnormal_lipoprotein_level1.26144845
60MP0001666_abnormal_nutrient_absorption1.25717493
61MP0001529_abnormal_vocalization1.24373469
62MP0005584_abnormal_enzyme/coenzyme_acti1.21294211
63MP0000749_muscle_degeneration1.20914040
64MP0003111_abnormal_nucleus_morphology1.17298204
65MP0008789_abnormal_olfactory_epithelium1.16833958
66MP0002822_catalepsy1.16298920
67MP0002653_abnormal_ependyma_morphology1.14104523
68MP0003656_abnormal_erythrocyte_physiolo1.12452961
69MP0010094_abnormal_chromosome_stability1.11776438
70MP0008058_abnormal_DNA_repair1.11106595
71MP0000751_myopathy1.10299107
72MP0001727_abnormal_embryo_implantation1.10027750
73MP0002210_abnormal_sex_determination1.09755647
74MP0002095_abnormal_skin_pigmentation1.05669929
75MP0001730_embryonic_growth_arrest1.05635410
76MP0005376_homeostasis/metabolism_phenot1.05309766
77MP0005451_abnormal_body_composition1.04965172
78MP0002269_muscular_atrophy1.04914124
79MP0000681_abnormal_thyroid_gland1.03357285
80MP0004036_abnormal_muscle_relaxation1.03011747
81MP0002118_abnormal_lipid_homeostasis1.02553473
82MP0002332_abnormal_exercise_endurance1.01612135
83MP0000609_abnormal_liver_physiology1.00835824
84MP0004130_abnormal_muscle_cell1.00605934
85MP0001346_abnormal_lacrimal_gland0.99251597
86MP0004858_abnormal_nervous_system0.97421476
87MP0005408_hypopigmentation0.97134419
88MP0002019_abnormal_tumor_incidence0.96895479
89MP0001661_extended_life_span0.95891745
90MP0000013_abnormal_adipose_tissue0.95327132
91MP0005666_abnormal_adipose_tissue0.92638363
92MP0002796_impaired_skin_barrier0.92453470
93MP0003567_abnormal_fetal_cardiomyocyte0.91611146
94MP0003786_premature_aging0.90766965
95MP0010030_abnormal_orbit_morphology0.88750316
96MP0005394_taste/olfaction_phenotype0.88598101
97MP0005499_abnormal_olfactory_system0.88598101
98MP0005389_reproductive_system_phenotype0.86898775
99MP0002638_abnormal_pupillary_reflex0.86324284
100MP0000747_muscle_weakness0.85804372
101MP0000490_abnormal_crypts_of0.84166103
102MP0001853_heart_inflammation0.83803397
103MP0010234_abnormal_vibrissa_follicle0.83712795
104MP0005385_cardiovascular_system_phenoty0.83149759
105MP0001544_abnormal_cardiovascular_syste0.83149759
106MP0008775_abnormal_heart_ventricle0.81945751
107MP0001697_abnormal_embryo_size0.79835660
108MP0005535_abnormal_body_temperature0.79663843
109MP0002972_abnormal_cardiac_muscle0.77858164
110MP0009697_abnormal_copulation0.77348134
111MP0002078_abnormal_glucose_homeostasis0.76404191
112MP0002160_abnormal_reproductive_system0.75204697
113MP0001929_abnormal_gametogenesis0.72543862
114MP0000230_abnormal_systemic_arterial0.71820861
115MP0000462_abnormal_digestive_system0.71503000
116MP0004133_heterotaxia0.71341492
117MP0002971_abnormal_brown_adipose0.70608277
118MP0005187_abnormal_penis_morphology0.70459815
119MP0000598_abnormal_liver_morphology0.69813922
120MP0000015_abnormal_ear_pigmentation0.68815277
121MP0001145_abnormal_male_reproductive0.68809080
122MP0002234_abnormal_pharynx_morphology0.68620539
123MP0002098_abnormal_vibrissa_morphology0.68195312
124MP0000759_abnormal_skeletal_muscle0.67653108
125MP0000343_altered_response_to0.67520206
126MP0001919_abnormal_reproductive_system0.66996124
127MP0002080_prenatal_lethality0.66551021
128MP0000627_abnormal_mammary_gland0.66378667
129MP0009642_abnormal_blood_homeostasis0.65875905
130MP0003252_abnormal_bile_duct0.65861524
131MP0003137_abnormal_impulse_conducting0.65330844
132MP0002138_abnormal_hepatobiliary_system0.65081700
133MP0002106_abnormal_muscle_physiology0.64464305
134MP0008260_abnormal_autophagy0.64182800
135MP0000372_irregular_coat_pigmentation0.62870743
136MP0005165_increased_susceptibility_to0.61815458
137MP0005220_abnormal_exocrine_pancreas0.61016361
138MP0002909_abnormal_adrenal_gland0.60175024
139MP0005384_cellular_phenotype0.59364525
140MP0000653_abnormal_sex_gland0.57839875
141MP0003191_abnormal_cellular_cholesterol0.55746316
142MP0010771_integument_phenotype0.55723189
143MP0003959_abnormal_lean_body0.53895998
144MP0003011_delayed_dark_adaptation0.53894876
145MP0005380_embryogenesis_phenotype0.53244885
146MP0001672_abnormal_embryogenesis/_devel0.53244885
147MP0002161_abnormal_fertility/fecundity0.52610538
148MP0004185_abnormal_adipocyte_glucose0.52300466
149MP0002970_abnormal_white_adipose0.52260804
150MP0005423_abnormal_somatic_nervous0.51616161

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.13336945
2Abnormal mitochondria in muscle tissue (HP:0008316)5.91564347
3Acute encephalopathy (HP:0006846)5.57386484
4Mitochondrial inheritance (HP:0001427)5.23823986
5Hepatic necrosis (HP:0002605)5.11231213
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.95975017
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.95975017
8Progressive macrocephaly (HP:0004481)4.88771256
9Increased CSF lactate (HP:0002490)4.80835693
10Hepatocellular necrosis (HP:0001404)4.78729770
11Cerebral edema (HP:0002181)4.54804901
12Lactic acidosis (HP:0003128)4.12022054
13Abnormality of cells of the erythroid lineage (HP:0012130)4.08557127
14Lipid accumulation in hepatocytes (HP:0006561)4.05246699
15Increased muscle lipid content (HP:0009058)3.99361407
16Increased intramyocellular lipid droplets (HP:0012240)3.96115462
17Increased hepatocellular lipid droplets (HP:0006565)3.92517855
18Abnormal number of erythroid precursors (HP:0012131)3.89009342
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.82641036
20Increased serum lactate (HP:0002151)3.77060209
21Dicarboxylic aciduria (HP:0003215)3.64695059
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.64695059
23Respiratory failure (HP:0002878)3.57726718
24Exercise intolerance (HP:0003546)3.56142968
25Hypoglycemic coma (HP:0001325)3.41409210
26Increased serum pyruvate (HP:0003542)3.40592594
27Abnormality of glycolysis (HP:0004366)3.40592594
28Lethargy (HP:0001254)3.35618359
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34806459
30Generalized aminoaciduria (HP:0002909)3.32124914
31Abnormality of aromatic amino acid family metabolism (HP:0004338)3.18937961
32Nausea (HP:0002018)3.10265697
33Abnormality of fatty-acid metabolism (HP:0004359)3.09426442
34Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08670703
35Testicular atrophy (HP:0000029)3.02576157
36Hyperglycinuria (HP:0003108)2.96616387
37Renal Fanconi syndrome (HP:0001994)2.90704084
383-Methylglutaconic aciduria (HP:0003535)2.88028769
39Abnormality of urine glucose concentration (HP:0011016)2.87085829
40Glycosuria (HP:0003076)2.87085829
41Palpitations (HP:0001962)2.86100037
42Macrocytic anemia (HP:0001972)2.85964004
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85348718
44Abnormality of alanine metabolism (HP:0010916)2.85348718
45Hyperalaninemia (HP:0003348)2.85348718
46Rhabdomyolysis (HP:0003201)2.84925916
47Cholecystitis (HP:0001082)2.81868772
48Abnormal gallbladder physiology (HP:0012438)2.81868772
49Reticulocytopenia (HP:0001896)2.78895751
50Multiple enchondromatosis (HP:0005701)2.78097588
51Leukodystrophy (HP:0002415)2.73913748
52CNS demyelination (HP:0007305)2.73718279
53Methylmalonic aciduria (HP:0012120)2.70291145
54Hyperammonemia (HP:0001987)2.69898319
55Type I transferrin isoform profile (HP:0003642)2.69121560
56Myoglobinuria (HP:0002913)2.63451342
57Optic disc pallor (HP:0000543)2.62658469
58Abnormality of the anterior horn cell (HP:0006802)2.62230246
59Degeneration of anterior horn cells (HP:0002398)2.62230246
60Hypokinesia (HP:0002375)2.56864463
61Hyperglycinemia (HP:0002154)2.55094671
62Exertional dyspnea (HP:0002875)2.52860961
63Ragged-red muscle fibers (HP:0003200)2.52821693
64Ketoacidosis (HP:0001993)2.52104583
65Vomiting (HP:0002013)2.51899480
66Hyperthyroidism (HP:0000836)2.51863539
67Oral leukoplakia (HP:0002745)2.49843413
68Abnormality of glycine metabolism (HP:0010895)2.48524295
69Abnormality of serine family amino acid metabolism (HP:0010894)2.48524295
70Ketosis (HP:0001946)2.47374042
71Respiratory difficulties (HP:0002880)2.45709825
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42951556
73Hyperphosphaturia (HP:0003109)2.42117996
74Abnormality of reticulocytes (HP:0004312)2.41294697
75Emotional lability (HP:0000712)2.35263966
76Proximal tubulopathy (HP:0000114)2.31632796
77Metabolic acidosis (HP:0001942)2.29787564
78Progressive muscle weakness (HP:0003323)2.29546969
79Abnormality of serum amino acid levels (HP:0003112)2.29106430
80Microvesicular hepatic steatosis (HP:0001414)2.25887273
81Pancytopenia (HP:0001876)2.22085055
82Abnormal protein glycosylation (HP:0012346)2.20484366
83Abnormal glycosylation (HP:0012345)2.20484366
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20484366
85Abnormal protein N-linked glycosylation (HP:0012347)2.20484366
86Gout (HP:0001997)2.19501790
87Truncus arteriosus (HP:0001660)2.19350706
88Opisthotonus (HP:0002179)2.18311520
89Pallor (HP:0000980)2.12448309
90Neuroendocrine neoplasm (HP:0100634)2.11549370
91Delayed CNS myelination (HP:0002188)2.10141785
92Microretrognathia (HP:0000308)2.07435115
93Pheochromocytoma (HP:0002666)2.06603083
94Reduced antithrombin III activity (HP:0001976)2.02804577
95Hypertensive crisis (HP:0100735)1.97364841
96Myopathic facies (HP:0002058)1.97261103
97Hypobetalipoproteinemia (HP:0003563)1.97118648
98Neoplasm of the adrenal gland (HP:0100631)1.96431907
99Late onset (HP:0003584)1.95718793
100Brushfield spots (HP:0001088)1.91657277
101Abnormality of renal resorption (HP:0011038)1.90933385
102Progressive microcephaly (HP:0000253)1.90922934
103Conjunctival hamartoma (HP:0100780)1.89967259
104Spastic paraparesis (HP:0002313)1.88570374
105Abnormal urine phosphate concentration (HP:0012599)1.87626627
106Breast hypoplasia (HP:0003187)1.84499635
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.83183144
108Megaloblastic anemia (HP:0001889)1.83088294
109Gliosis (HP:0002171)1.82445388
110Aplastic anemia (HP:0001915)1.81648931
111Xanthomatosis (HP:0000991)1.81644521
112Abnormal trabecular bone morphology (HP:0100671)1.81137765
113Death in infancy (HP:0001522)1.79012409
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78237135
115Rough bone trabeculation (HP:0100670)1.78232206
116Sparse eyelashes (HP:0000653)1.77340122
117Redundant skin (HP:0001582)1.76018467
118Seborrheic dermatitis (HP:0001051)1.74232115
119Broad distal phalanx of finger (HP:0009836)1.73960338
120CNS hypomyelination (HP:0003429)1.73072745
121Trismus (HP:0000211)1.72199638
122Unsteady gait (HP:0002317)1.71899443
123Cerebral hypomyelination (HP:0006808)1.71344322
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71299089
125Hyperlipoproteinemia (HP:0010980)1.70796512
126Secondary amenorrhea (HP:0000869)1.68639036
127Esophageal neoplasm (HP:0100751)1.66956104
128Neoplasm of head and neck (HP:0012288)1.66956104
129X-linked dominant inheritance (HP:0001423)1.66585168
130Cholelithiasis (HP:0001081)1.63063970
131Fasciculations (HP:0002380)1.63039595
132Muscle stiffness (HP:0003552)1.61321488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.08258270
2BCKDK4.25184902
3STK163.99812816
4BUB13.86167257
5WEE13.35584782
6VRK23.33834366
7NME12.76706968
8EIF2AK12.72184459
9TESK22.71270802
10ARAF2.62476605
11IRAK32.50881079
12KDR2.21968776
13PIM22.07943612
14DYRK32.05941243
15MAPKAPK31.97580350
16NEK11.97359147
17ACVR1B1.82948159
18MAP3K111.78866890
19BRAF1.75660628
20MYLK1.68944054
21VRK11.68497847
22EIF2AK31.63180505
23TESK11.55296608
24LIMK11.46561672
25MST1R1.44462767
26WNK31.35880831
27PLK41.35209740
28MAP2K21.34246569
29MAP3K121.31545660
30SMG11.27266399
31ABL21.26756999
32LMTK21.25004362
33CCNB11.22915338
34SCYL21.22634907
35AURKA1.20898138
36BRSK21.19888681
37PDK31.11106077
38PDK41.11106077
39DYRK21.08355111
40TLK11.07037443
41TTK1.00865331
42OBSCN1.00845009
43PINK11.00688977
44ILK0.99730338
45RPS6KB20.99125758
46AURKB0.96009861
47PLK10.95025164
48SRPK10.94149534
49ERN10.91953198
50DAPK30.87563124
51CDC70.85129518
52WNK40.82854357
53RPS6KA40.82780571
54EPHA20.81033638
55TAOK20.80715131
56MUSK0.76282935
57CDK190.73330855
58ICK0.72099258
59PASK0.71903326
60ZAK0.71057699
61PBK0.70961415
62MAP3K80.70066262
63FLT30.69522969
64LRRK20.68493792
65MAP2K70.67606025
66PRKCI0.67548667
67PAK10.67491856
68TSSK60.66602582
69CDK140.66082811
70PAK40.65028871
71BRSK10.63831190
72MAPKAPK50.63687047
73CSNK2A10.63506743
74CDK11A0.61322210
75CAMK2G0.60696597
76CSNK2A20.59735499
77MAPK150.59037548
78CDK70.58537438
79STK40.58153240
80CSNK1A1L0.57146380
81ERBB40.56543984
82CAMK2D0.55858891
83CDK150.54380784
84KSR20.53558907
85INSRR0.53254950
86GRK60.53227352
87RPS6KA50.50851216
88PDK20.50465791
89CDK180.50310899
90CHEK10.50195948
91MAP3K90.49398730
92STK38L0.49206034
93RAF10.49175936
94MAP3K30.49037607
95PIK3CA0.48327706
96PIK3CG0.48254068
97DAPK10.48226852
98NEK20.48071239
99MAP2K10.44881906
100CSNK1G30.43032734
101CSNK1G20.42089433
102PHKG20.41797131
103PHKG10.41797131
104AKT20.39411735
105IRAK20.37304384
106STK240.37194472
107CAMKK20.37007460
108MST40.36983313
109PRKG20.35938863
110DYRK1B0.35870172
111MINK10.35534918
112CHEK20.35404648
113TRIB30.34075693
114CSNK1G10.31577836
115PLK30.29424435
116CDK80.29288720
117CDK40.28169458
118MAPK110.27493997
119MET0.27231377
120CAMK2B0.26357858
121ATR0.24099083
122MAP3K50.22586320
123MOS0.22473386
124PAK60.21864575
125CDK20.21806244
126CDK10.21433380
127EEF2K0.21337506

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.29185290
2Parkinsons disease_Homo sapiens_hsa050123.96476195
3Ribosome_Homo sapiens_hsa030103.81923892
4Proteasome_Homo sapiens_hsa030503.42068119
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.85119235
6Huntingtons disease_Homo sapiens_hsa050162.83302773
7Alzheimers disease_Homo sapiens_hsa050102.67990798
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.58083194
9RNA polymerase_Homo sapiens_hsa030202.48055332
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18207043
11DNA replication_Homo sapiens_hsa030302.10199659
12Folate biosynthesis_Homo sapiens_hsa007902.00808617
13Pyrimidine metabolism_Homo sapiens_hsa002402.00520280
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98927863
15Propanoate metabolism_Homo sapiens_hsa006401.96000715
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90201185
17Sulfur metabolism_Homo sapiens_hsa009201.85431538
18Cardiac muscle contraction_Homo sapiens_hsa042601.76038579
19Sulfur relay system_Homo sapiens_hsa041221.75306978
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75204583
21Protein export_Homo sapiens_hsa030601.74756310
22Carbon metabolism_Homo sapiens_hsa012001.74603943
23Pyruvate metabolism_Homo sapiens_hsa006201.62596188
24Fatty acid degradation_Homo sapiens_hsa000711.54435454
25Mismatch repair_Homo sapiens_hsa034301.52999530
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42250610
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40965374
28Spliceosome_Homo sapiens_hsa030401.39595502
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.36253207
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35267543
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.33699634
32Butanoate metabolism_Homo sapiens_hsa006501.25636881
33Peroxisome_Homo sapiens_hsa041461.25126478
34Biosynthesis of amino acids_Homo sapiens_hsa012301.21480796
35Glutathione metabolism_Homo sapiens_hsa004801.19373987
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15684518
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15485777
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11942797
39Pentose phosphate pathway_Homo sapiens_hsa000301.10139581
40Nucleotide excision repair_Homo sapiens_hsa034201.09016774
41Base excision repair_Homo sapiens_hsa034101.08457443
42Fanconi anemia pathway_Homo sapiens_hsa034601.07641995
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06886030
44Selenocompound metabolism_Homo sapiens_hsa004501.06340861
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05812820
46RNA transport_Homo sapiens_hsa030131.04538801
47Fatty acid elongation_Homo sapiens_hsa000621.04380530
48Phenylalanine metabolism_Homo sapiens_hsa003601.01796505
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01584239
50Homologous recombination_Homo sapiens_hsa034401.01010195
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00451974
52Purine metabolism_Homo sapiens_hsa002300.99602560
53Metabolic pathways_Homo sapiens_hsa011000.98738630
54One carbon pool by folate_Homo sapiens_hsa006700.97485096
55Tryptophan metabolism_Homo sapiens_hsa003800.97219315
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96283992
57Fatty acid metabolism_Homo sapiens_hsa012120.93530792
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.91999818
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89201361
60beta-Alanine metabolism_Homo sapiens_hsa004100.88338868
61Tyrosine metabolism_Homo sapiens_hsa003500.86861067
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85292597
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.83315963
64Arginine and proline metabolism_Homo sapiens_hsa003300.79266219
65Fat digestion and absorption_Homo sapiens_hsa049750.78585798
66Chemical carcinogenesis_Homo sapiens_hsa052040.78318923
67Fructose and mannose metabolism_Homo sapiens_hsa000510.76321520
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.74012622
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72606803
70Galactose metabolism_Homo sapiens_hsa000520.72271145
71Histidine metabolism_Homo sapiens_hsa003400.69007104
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68943196
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67326124
74PPAR signaling pathway_Homo sapiens_hsa033200.66237533
75Collecting duct acid secretion_Homo sapiens_hsa049660.65523923
76Alcoholism_Homo sapiens_hsa050340.62953906
77Regulation of autophagy_Homo sapiens_hsa041400.60677946
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54464680
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52354102
80Starch and sucrose metabolism_Homo sapiens_hsa005000.51430118
81Linoleic acid metabolism_Homo sapiens_hsa005910.50909158
82Basal transcription factors_Homo sapiens_hsa030220.50108128
83RNA degradation_Homo sapiens_hsa030180.49065222
84Arginine biosynthesis_Homo sapiens_hsa002200.49018831
85Steroid biosynthesis_Homo sapiens_hsa001000.48155528
86Cell cycle_Homo sapiens_hsa041100.43977768
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.43487307
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43328112
89Retinol metabolism_Homo sapiens_hsa008300.43134627
90Synaptic vesicle cycle_Homo sapiens_hsa047210.40284214
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38998252
92Vitamin B6 metabolism_Homo sapiens_hsa007500.37539733
93Arachidonic acid metabolism_Homo sapiens_hsa005900.37366090
94Systemic lupus erythematosus_Homo sapiens_hsa053220.33606468
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33031192
96Caffeine metabolism_Homo sapiens_hsa002320.32435493
97p53 signaling pathway_Homo sapiens_hsa041150.29064179
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28384367
99Bladder cancer_Homo sapiens_hsa052190.27605296
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26767339
101Glycerolipid metabolism_Homo sapiens_hsa005610.25973446
102Shigellosis_Homo sapiens_hsa051310.25367280
103mRNA surveillance pathway_Homo sapiens_hsa030150.22679723
104Viral carcinogenesis_Homo sapiens_hsa052030.21878882
105Non-homologous end-joining_Homo sapiens_hsa034500.21664574
106Vibrio cholerae infection_Homo sapiens_hsa051100.20811910
107Vitamin digestion and absorption_Homo sapiens_hsa049770.20484500
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19135448
109Oocyte meiosis_Homo sapiens_hsa041140.17953491
110Thyroid cancer_Homo sapiens_hsa052160.17304135
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16709797
112Epstein-Barr virus infection_Homo sapiens_hsa051690.16181738
113N-Glycan biosynthesis_Homo sapiens_hsa005100.16115860
114Other glycan degradation_Homo sapiens_hsa005110.13819517
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11614313
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.10399333
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10146339
118Prion diseases_Homo sapiens_hsa050200.10102166
119Apoptosis_Homo sapiens_hsa042100.03486733
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.00713137

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