ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	7.68288953
2	cytidine metabolic process (GO:0046087)	7.68288953
3	cytidine catabolic process (GO:0006216)	7.68288953
4	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.44723349
5	DNA deamination (GO:0045006)	6.83486751
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.54728365
7	cellular response to interleukin-15 (GO:0071350)	5.40741974
8	negative regulation by host of viral transcription (GO:0043922)	5.20700773
9	mannosylation (GO:0097502)	5.18476416
10	axoneme assembly (GO:0035082)	4.97918950
11	positive regulation of interleukin-8 secretion (GO:2000484)	4.97688845
12	regulation of lymphocyte chemotaxis (GO:1901623)	4.73905206
13	water-soluble vitamin biosynthetic process (GO:0042364)	4.48573162
14	behavioral response to nicotine (GO:0035095)	4.34982774
15	positive regulation of defense response to virus by host (GO:0002230)	4.31590636
16	sequestering of actin monomers (GO:0042989)	4.13805241
17	eosinophil chemotaxis (GO:0048245)	4.08280815
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.94941071
19	negative regulation of mast cell activation (GO:0033004)	3.89656147
20	protein complex biogenesis (GO:0070271)	3.86709702
21	nucleoside diphosphate catabolic process (GO:0009134)	3.85644696
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.78777588
23	NADH dehydrogenase complex assembly (GO:0010257)	3.78777588
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.78777588
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.77173172
26	response to interleukin-15 (GO:0070672)	3.75879235
27	axonemal dynein complex assembly (GO:0070286)	3.72813991
28	regulation of interleukin-8 secretion (GO:2000482)	3.68920467
29	eosinophil migration (GO:0072677)	3.67411396
30	regulation of T cell chemotaxis (GO:0010819)	3.61441288
31	positive regulation of T cell chemotaxis (GO:0010820)	3.61441288
32	motile cilium assembly (GO:0044458)	3.60757972
33	L-fucose catabolic process (GO:0042355)	3.58006802
34	fucose catabolic process (GO:0019317)	3.58006802
35	L-fucose metabolic process (GO:0042354)	3.58006802
36	GPI anchor biosynthetic process (GO:0006506)	3.56885655
37	N-glycan processing (GO:0006491)	3.52771744
38	positive regulation of lymphocyte migration (GO:2000403)	3.50323466
39	pyrimidine nucleoside catabolic process (GO:0046135)	3.46800195
40	cilium movement (GO:0003341)	3.41900221
41	positive regulation of calcium-mediated signaling (GO:0050850)	3.37415099
42	protein deneddylation (GO:0000338)	3.35769953
43	GPI anchor metabolic process (GO:0006505)	3.34894612
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34819660
45	synaptic transmission, cholinergic (GO:0007271)	3.34655287
46	regulation of cilium movement (GO:0003352)	3.32977932
47	positive regulation of protein sumoylation (GO:0033235)	3.29705836
48	arginine catabolic process (GO:0006527)	3.25920325
49	cellular response to nicotine (GO:0071316)	3.23453733
50	epithelial cilium movement (GO:0003351)	3.14607305
51	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.14106275
52	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.13687524
53	DNA demethylation (GO:0080111)	3.03647357
54	retinal cone cell development (GO:0046549)	3.00857103
55	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.96205834
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.95010411
57	ovulation cycle (GO:0042698)	2.93422396
58	regulation of B cell receptor signaling pathway (GO:0050855)	2.91749650
59	proteasome assembly (GO:0043248)	2.90079970
60	rRNA catabolic process (GO:0016075)	2.89537890
61	maturation of SSU-rRNA (GO:0030490)	2.89045656
62	adaptation of signaling pathway (GO:0023058)	2.87062493
63	ubiquinone biosynthetic process (GO:0006744)	2.86868004
64	fucose metabolic process (GO:0006004)	2.85097389
65	modulation by host of viral transcription (GO:0043921)	2.82759173
66	modulation by host of symbiont transcription (GO:0052472)	2.82759173
67	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.80857425
68	positive thymic T cell selection (GO:0045059)	2.79568600
69	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.79341634
70	negative regulation of viral transcription (GO:0032897)	2.77283560
71	female mating behavior (GO:0060180)	2.76350391
72	regulation of T cell receptor signaling pathway (GO:0050856)	2.75556542
73	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.74839067
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.74839067
75	regulation of calcium-mediated signaling (GO:0050848)	2.73311166
76	fucosylation (GO:0036065)	2.73298105
77	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.70929277
78	regulation of lymphocyte migration (GO:2000401)	2.70512040
79	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.67042874
80	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.65152410
81	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.64076460
82	retinal rod cell development (GO:0046548)	2.62620944
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61409722
84	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.61250595
85	macrophage chemotaxis (GO:0048246)	2.61106120
86	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.60444039
87	regulation of defense response to virus by host (GO:0050691)	2.59059957
88	DNA integration (GO:0015074)	2.56315150
89	regulation of T cell mediated cytotoxicity (GO:0001914)	2.55978525
90	tongue development (GO:0043586)	2.55160368
91	iron-sulfur cluster assembly (GO:0016226)	2.51405988
92	metallo-sulfur cluster assembly (GO:0031163)	2.51405988
93	cardiovascular system development (GO:0072358)	2.49887933
94	protein polyglutamylation (GO:0018095)	2.49281520
95	regulation of activation of Janus kinase activity (GO:0010533)	2.48837955
96	lymphocyte chemotaxis (GO:0048247)	2.47491289
97	C-terminal protein lipidation (GO:0006501)	2.46522632
98	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.46075790
99	hypothalamus development (GO:0021854)	2.45645221
100	positive regulation of cell killing (GO:0031343)	2.45388137

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	8.70759985
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.87135613
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.83025268
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.54610639
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.15846902
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.02124178
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.90074972
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.85175990
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.82286620
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63709950
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.57032648
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53207356
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.38043350
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.27693722
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.16810130
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.08844091
17	VDR_22108803_ChIP-Seq_LS180_Human	1.98186551
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97910752
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90429596
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.88984099
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81537762
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77697892
23	MYB_26560356_Chip-Seq_TH2_Human	1.74279682
24	RUNX_20019798_ChIP-Seq_JUKART_Human	1.74081579
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60916563
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.60138078
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55137959
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.54506402
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.54427675
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52148862
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.50460463
32	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.49958225
33	GATA3_26560356_Chip-Seq_TH2_Human	1.44964913
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39674291
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38670885
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33419470
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33042408
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.32195659
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30787895
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30787895
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30755815
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29225842
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.25116013
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21829256
45	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21653463
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.20751309
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.20287902
48	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12043823
49	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11252339
50	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.10857132
51	GATA3_27048872_Chip-Seq_THYMUS_Human	1.10775464
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09929326
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.09363123
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08087813
55	AR_20517297_ChIP-Seq_VCAP_Human	1.07677885
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07129250
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.07104540
58	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06284579
59	FUS_26573619_Chip-Seq_HEK293_Human	1.04805759
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03998116
61	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.03828813
62	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02995272
63	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01756823
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.00901681
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.00870004
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00063900
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98764026
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98546358
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96943788
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96926860
71	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96687350
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95398783
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95282936
74	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94807176
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93592524
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93105813
77	ERA_21632823_ChIP-Seq_H3396_Human	0.91010314
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90399031
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89938275
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88582873
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88199423
82	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.88024742
83	NCOR_22424771_ChIP-Seq_293T_Human	0.87625527
84	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87013584
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86742037
86	MYB_26560356_Chip-Seq_TH1_Human	0.86068448
87	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85881963
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.85767826
89	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85110293
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.84594827
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.83136778
92	UTX_26944678_Chip-Seq_JUKART_Human	0.80913545
93	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.80881649
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80466163
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80466163
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.80453969
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.79176271
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77665126
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.77665126
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77608477

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.84468054
2	MP0004147_increased_porphyrin_level	3.68525391
3	MP0003646_muscle_fatigue	3.09674043
4	MP0002653_abnormal_ependyma_morphology	2.78345358
5	MP0002638_abnormal_pupillary_reflex	2.65350017
6	MP0002277_abnormal_respiratory_mucosa	2.62887191
7	MP0006082_CNS_inflammation	2.62329399
8	MP0010386_abnormal_urinary_bladder	2.62047939
9	MP0006276_abnormal_autonomic_nervous	2.58705657
10	MP0003950_abnormal_plasma_membrane	2.56102601
11	MP0004381_abnormal_hair_follicle	2.52518604
12	MP0006072_abnormal_retinal_apoptosis	2.50452540
13	MP0003880_abnormal_central_pattern	2.31945745
14	MP0005075_abnormal_melanosome_morpholog	2.31850949
15	MP0005451_abnormal_body_composition	2.24685784
16	MP0005671_abnormal_response_to	2.24079105
17	MP0006292_abnormal_olfactory_placode	2.20135808
18	MP0003763_abnormal_thymus_physiology	2.11877325
19	MP0005387_immune_system_phenotype	1.99942842
20	MP0001790_abnormal_immune_system	1.99942842
21	MP0003011_delayed_dark_adaptation	1.93035129
22	MP0000538_abnormal_urinary_bladder	1.86983961
23	MP0002148_abnormal_hypersensitivity_rea	1.82804266
24	MP0002234_abnormal_pharynx_morphology	1.79395996
25	MP0003136_yellow_coat_color	1.77741968
26	MP0005551_abnormal_eye_electrophysiolog	1.76966732
27	MP0005253_abnormal_eye_physiology	1.72318015
28	MP0001800_abnormal_humoral_immune	1.71072828
29	MP0009333_abnormal_splenocyte_physiolog	1.63518201
30	MP0009379_abnormal_foot_pigmentation	1.60656590
31	MP0003866_abnormal_defecation	1.51656131
32	MP0005000_abnormal_immune_tolerance	1.48218467
33	MP0002837_dystrophic_cardiac_calcinosis	1.46766949
34	MP0002723_abnormal_immune_serum	1.46586644
35	MP0001968_abnormal_touch/_nociception	1.44514447
36	MP0004043_abnormal_pH_regulation	1.41701464
37	MP0008877_abnormal_DNA_methylation	1.41674858
38	MP0002736_abnormal_nociception_after	1.39943336
39	MP0008872_abnormal_physiological_respon	1.32494055
40	MP0001905_abnormal_dopamine_level	1.30593090
41	MP0002420_abnormal_adaptive_immunity	1.30045106
42	MP0002876_abnormal_thyroid_physiology	1.27926222
43	MP0002405_respiratory_system_inflammati	1.27349915
44	MP0001873_stomach_inflammation	1.27166186
45	MP0008789_abnormal_olfactory_epithelium	1.27081488
46	MP0001819_abnormal_immune_cell	1.23103349
47	MP0000569_abnormal_digit_pigmentation	1.21878836
48	MP0005332_abnormal_amino_acid	1.15826999
49	MP0004133_heterotaxia	1.15268567
50	MP0003656_abnormal_erythrocyte_physiolo	1.15249313
51	MP0003724_increased_susceptibility_to	1.15116804
52	MP0004145_abnormal_muscle_electrophysio	1.14509790
53	MP0001958_emphysema	1.14238793
54	MP0010368_abnormal_lymphatic_system	1.12216623
55	MP0002877_abnormal_melanocyte_morpholog	1.07752188
56	MP0004142_abnormal_muscle_tone	1.04427139
57	MP0000685_abnormal_immune_system	1.03408060
58	MP0009780_abnormal_chondrocyte_physiolo	1.03296828
59	MP0009785_altered_susceptibility_to	1.00207395
60	MP0003879_abnormal_hair_cell	0.99443387
61	MP0000566_synostosis	0.97969404
62	MP0002282_abnormal_trachea_morphology	0.97703715
63	MP0002452_abnormal_antigen_presenting	0.97506283
64	MP0005025_abnormal_response_to	0.97254319
65	MP0008875_abnormal_xenobiotic_pharmacok	0.94912398
66	MP0009053_abnormal_anal_canal	0.94295937
67	MP0009745_abnormal_behavioral_response	0.93538099
68	MP0001835_abnormal_antigen_presentation	0.90241841
69	MP0001970_abnormal_pain_threshold	0.89960307
70	MP0002733_abnormal_thermal_nociception	0.89656798
71	MP0001293_anophthalmia	0.88968257
72	MP0005195_abnormal_posterior_eye	0.87740694
73	MP0002398_abnormal_bone_marrow	0.87692220
74	MP0000716_abnormal_immune_system	0.87491654
75	MP0005391_vision/eye_phenotype	0.86733653
76	MP0000689_abnormal_spleen_morphology	0.83826546
77	MP0001845_abnormal_inflammatory_respons	0.81538335
78	MP0009643_abnormal_urine_homeostasis	0.81452548
79	MP0005645_abnormal_hypothalamus_physiol	0.80371428
80	MP0002938_white_spotting	0.78446134
81	MP0001666_abnormal_nutrient_absorption	0.78054637
82	MP0002132_abnormal_respiratory_system	0.76954224
83	MP0003045_fibrosis	0.76883809
84	MP0002933_joint_inflammation	0.75372432
85	MP0002163_abnormal_gland_morphology	0.75127528
86	MP0005174_abnormal_tail_pigmentation	0.72784472
87	MP0001756_abnormal_urination	0.72560775
88	MP0002693_abnormal_pancreas_physiology	0.71080337
89	MP0005165_increased_susceptibility_to	0.69122795
90	MP0001963_abnormal_hearing_physiology	0.66345595
91	MP0009840_abnormal_foam_cell	0.65614823
92	MP0002429_abnormal_blood_cell	0.64688498
93	MP0004924_abnormal_behavior	0.63428559
94	MP0005386_behavior/neurological_phenoty	0.63428559
95	MP0002735_abnormal_chemical_nociception	0.63377608
96	MP0008469_abnormal_protein_level	0.63282643
97	MP0001533_abnormal_skeleton_physiology	0.62107993
98	MP0005499_abnormal_olfactory_system	0.61026922
99	MP0005394_taste/olfaction_phenotype	0.61026922
100	MP0002751_abnormal_autonomic_nervous	0.59734538

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.19817914
2	Absent/shortened dynein arms (HP:0200106)	6.19817914
3	T lymphocytopenia (HP:0005403)	4.70315881
4	Abnormal respiratory motile cilium morphology (HP:0005938)	4.53868908
5	Abnormal respiratory epithelium morphology (HP:0012253)	4.53868908
6	Abnormality of T cell number (HP:0011839)	4.41337253
7	Concave nail (HP:0001598)	4.37645220
8	Abnormal ciliary motility (HP:0012262)	4.33017118
9	Chronic hepatic failure (HP:0100626)	3.86925805
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.62635631
11	Abnormal respiratory motile cilium physiology (HP:0012261)	3.44843899
12	Abnormality of midbrain morphology (HP:0002418)	3.35795323
13	Molar tooth sign on MRI (HP:0002419)	3.35795323
14	Type II lissencephaly (HP:0007260)	3.25829820
15	Abnormality of the pons (HP:0007361)	3.18549370
16	Mitochondrial inheritance (HP:0001427)	3.07912683
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.98683562
18	Abnormality of T cells (HP:0002843)	2.97564956
19	Renal cortical cysts (HP:0000803)	2.96507996
20	Aplastic anemia (HP:0001915)	2.92647318
21	IgG deficiency (HP:0004315)	2.89743272
22	Acute encephalopathy (HP:0006846)	2.87050151
23	Congenital, generalized hypertrichosis (HP:0004540)	2.85357417
24	Severe combined immunodeficiency (HP:0004430)	2.79709223
25	Acute necrotizing encephalopathy (HP:0006965)	2.79103000
26	Increased intramyocellular lipid droplets (HP:0012240)	2.73354684
27	Renal Fanconi syndrome (HP:0001994)	2.73313350
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.70428326
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.70254270
30	Type I transferrin isoform profile (HP:0003642)	2.67223958
31	Cerebellar dysplasia (HP:0007033)	2.64161418
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.61027562
33	Recurrent bronchitis (HP:0002837)	2.60985041
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59879838
35	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.58812068
36	Thyroiditis (HP:0100646)	2.57341199
37	Hypoplasia of the pons (HP:0012110)	2.52190304
38	Joint swelling (HP:0001386)	2.50851065
39	Increased hepatocellular lipid droplets (HP:0006565)	2.42014603
40	Recurrent sinusitis (HP:0011108)	2.40612822
41	Nephronophthisis (HP:0000090)	2.39569247
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36875185
43	Porencephaly (HP:0002132)	2.36123096
44	Increased CSF lactate (HP:0002490)	2.33891694
45	Abnormality of eosinophils (HP:0001879)	2.31205618
46	Recurrent corneal erosions (HP:0000495)	2.30994967
47	Progressive macrocephaly (HP:0004481)	2.30084027
48	Anhidrosis (HP:0000970)	2.28505161
49	Abnormality of the renal cortex (HP:0011035)	2.28164722
50	Autoimmune hemolytic anemia (HP:0001890)	2.23191686
51	Methylmalonic aciduria (HP:0012120)	2.20604150
52	Increased muscle lipid content (HP:0009058)	2.20444555
53	Bronchiectasis (HP:0002110)	2.19891085
54	Large for gestational age (HP:0001520)	2.19765920
55	Abnormality of dental color (HP:0011073)	2.11251794
56	IgM deficiency (HP:0002850)	2.10365499
57	Bronchitis (HP:0012387)	2.09343030
58	Optic disc pallor (HP:0000543)	2.08564945
59	Abnormality of the renal medulla (HP:0100957)	2.07360615
60	Hepatocellular necrosis (HP:0001404)	2.06616341
61	Palpitations (HP:0001962)	2.03880291
62	Abnormality of the renal collecting system (HP:0004742)	2.01809394
63	Duplicated collecting system (HP:0000081)	1.98457146
64	Lipid accumulation in hepatocytes (HP:0006561)	1.97569510
65	Combined immunodeficiency (HP:0005387)	1.96435539
66	Recurrent viral infections (HP:0004429)	1.95676542
67	Autoamputation (HP:0001218)	1.95208720
68	Severe muscular hypotonia (HP:0006829)	1.93501247
69	Brushfield spots (HP:0001088)	1.93493589
70	IgA deficiency (HP:0002720)	1.93484681
71	Cortical visual impairment (HP:0100704)	1.93282897
72	Lissencephaly (HP:0001339)	1.93243275
73	Methylmalonic acidemia (HP:0002912)	1.92081865
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.89439528
75	Abnormal protein glycosylation (HP:0012346)	1.89439528
76	Abnormal glycosylation (HP:0012345)	1.89439528
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89439528
78	Abnormality of abdominal situs (HP:0011620)	1.89417966
79	Abdominal situs inversus (HP:0003363)	1.89417966
80	Vacuolated lymphocytes (HP:0001922)	1.89224522
81	Congenital stationary night blindness (HP:0007642)	1.88950716
82	Pancreatic cysts (HP:0001737)	1.88384774
83	Constricted visual fields (HP:0001133)	1.87136977
84	Hepatic necrosis (HP:0002605)	1.84486927
85	Hyperglycinemia (HP:0002154)	1.84352786
86	Sensory axonal neuropathy (HP:0003390)	1.84276784
87	Hypoproteinemia (HP:0003075)	1.82724151
88	Oral leukoplakia (HP:0002745)	1.82088218
89	Hyperglycinuria (HP:0003108)	1.76803660
90	Severe visual impairment (HP:0001141)	1.76624586
91	Bifid tongue (HP:0010297)	1.75698024
92	Rhinitis (HP:0012384)	1.75163397
93	Hypophosphatemic rickets (HP:0004912)	1.75110594
94	Abnormality of T cell physiology (HP:0011840)	1.74626690
95	Exercise intolerance (HP:0003546)	1.74495741
96	Conical tooth (HP:0000698)	1.74463559
97	Chronic diarrhea (HP:0002028)	1.74323812
98	Infantile muscular hypotonia (HP:0008947)	1.73955730
99	Cerebral edema (HP:0002181)	1.71626287
100	Recurrent cutaneous fungal infections (HP:0011370)	1.71560868

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.29292962
2	TXK	5.03015903
3	BCKDK	3.56530692
4	MAP4K2	3.12733758
5	MAPKAPK3	3.05904904
6	KDR	2.65759780
7	FRK	2.43737741
8	MATK	2.41336737
9	NTRK1	2.15816724
10	FES	2.11379269
11	LIMK1	2.04982555
12	EIF2AK1	2.04481506
13	TLK1	2.01235078
14	ZAK	1.82099039
15	PIK3CA	1.74262987
16	MAP3K11	1.70108314
17	MAP4K1	1.61327821
18	CDK8	1.59846660
19	TESK1	1.59256613
20	ADRBK2	1.44833355
21	BUB1	1.40786936
22	WNK3	1.40563782
23	ITK	1.34639376
24	KIT	1.34482509
25	MARK3	1.33559963
26	MAPK13	1.32393467
27	PRKCQ	1.31876019
28	MAP3K7	1.31073108
29	EIF2AK3	1.29271135
30	GRK1	1.22825282
31	STK16	1.22643875
32	FER	1.18500337
33	SYK	1.13841527
34	NUAK1	1.13720476
35	PAK3	1.09741067
36	MAP3K4	1.08690418
37	TEC	1.07918595
38	TAOK1	1.05278096
39	MAP2K6	1.01322153
40	CAMKK2	1.00250636
41	LCK	0.95917625
42	PDK2	0.95706014
43	WNK4	0.92286332
44	TESK2	0.92122749
45	STK38L	0.89228281
46	WNK1	0.86849979
47	GRK6	0.86181074
48	NLK	0.76404191
49	INSRR	0.72077265
50	ADRBK1	0.71419754
51	PKN1	0.70410955
52	MAPK15	0.70381817
53	TIE1	0.69939104
54	SCYL2	0.69424377
55	LYN	0.67167022
56	IKBKB	0.66499365
57	BMPR1B	0.64465798
58	PHKG1	0.61899507
59	PHKG2	0.61899507
60	BTK	0.56084476
61	LRRK2	0.55028529
62	INSR	0.54410466
63	BMPR2	0.54099409
64	CAMK1	0.53114065
65	ERBB3	0.52682286
66	PINK1	0.51072916
67	FYN	0.49893996
68	STK10	0.49530493
69	GRK7	0.48249737
70	MAP2K2	0.47684206
71	MAP3K14	0.45479730
72	IGF1R	0.45398256
73	CSK	0.45209602
74	DYRK2	0.45160919
75	OBSCN	0.45074723
76	PRKCA	0.45029112
77	PRKCE	0.44153052
78	ERBB2	0.43441935
79	SRPK1	0.43366019
80	DAPK1	0.39713662
81	VRK1	0.38932797
82	MAPKAPK2	0.37619150
83	MYLK	0.37396764
84	CSF1R	0.37141328
85	PRKACA	0.36219953
86	DAPK2	0.34821436
87	BCR	0.32666573
88	PRKD2	0.32389832
89	MAPK11	0.32292192
90	ILK	0.30154265
91	STK11	0.30097051
92	CAMK2D	0.29724361
93	NME1	0.28104444
94	MUSK	0.27874275
95	PRKCD	0.27172974
96	TNIK	0.26781386
97	CASK	0.26711311
98	CAMK2A	0.26317210
99	ABL1	0.25362359
100	ACVR1B	0.23885920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.90336535
2	Protein export_Homo sapiens_hsa03060	3.31213538
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.00413953
4	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.93553973
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.85948196
6	Proteasome_Homo sapiens_hsa03050	2.84526630
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.71589413
8	Ribosome_Homo sapiens_hsa03010	2.53355964
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.41637956
10	Parkinsons disease_Homo sapiens_hsa05012	2.18776371
11	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.16680383
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.05139329
13	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.03614088
14	Phototransduction_Homo sapiens_hsa04744	2.02652764
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.97853026
16	Allograft rejection_Homo sapiens_hsa05330	1.92835580
17	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.83500910
18	RNA polymerase_Homo sapiens_hsa03020	1.83369355
19	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.76262102
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.70055964
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.66007766
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.62909207
23	Regulation of autophagy_Homo sapiens_hsa04140	1.58561432
24	Alzheimers disease_Homo sapiens_hsa05010	1.54037202
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.53211806
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.49827195
27	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.44425731
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43955771
29	Huntingtons disease_Homo sapiens_hsa05016	1.35092037
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33868976
31	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.32906918
32	Sulfur metabolism_Homo sapiens_hsa00920	1.29678792
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28970543
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28354661
35	Propanoate metabolism_Homo sapiens_hsa00640	1.21709808
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18727408
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17935201
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.16939912
39	Peroxisome_Homo sapiens_hsa04146	1.12224979
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11035703
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10793380
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09304559
43	Salmonella infection_Homo sapiens_hsa05132	1.08444350
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08366741
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08305736
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06020559
47	Caffeine metabolism_Homo sapiens_hsa00232	1.04380816
48	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.04105862
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96093673
50	Circadian rhythm_Homo sapiens_hsa04710	0.90863417
51	Homologous recombination_Homo sapiens_hsa03440	0.90099209
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88300152
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.83873680
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.81868111
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81107107
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72390357
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71469017
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.70116699
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.69277040
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68803468
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68641971
62	Metabolic pathways_Homo sapiens_hsa01100	0.66616001
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66063536
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65849317
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63445704
66	Asthma_Homo sapiens_hsa05310	0.62823057
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.59894298
68	Purine metabolism_Homo sapiens_hsa00230	0.58663410
69	Fatty acid degradation_Homo sapiens_hsa00071	0.57213446
70	RNA degradation_Homo sapiens_hsa03018	0.56126648
71	Retinol metabolism_Homo sapiens_hsa00830	0.55731048
72	One carbon pool by folate_Homo sapiens_hsa00670	0.53959954
73	Nicotine addiction_Homo sapiens_hsa05033	0.50844552
74	Measles_Homo sapiens_hsa05162	0.48931177
75	Salivary secretion_Homo sapiens_hsa04970	0.46988785
76	Olfactory transduction_Homo sapiens_hsa04740	0.46946020
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45046047
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.41104899
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40768912
80	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.40100537
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.40099986
82	Basal transcription factors_Homo sapiens_hsa03022	0.39629897
83	Butanoate metabolism_Homo sapiens_hsa00650	0.39493414
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39145241
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35431367
86	Chemokine signaling pathway_Homo sapiens_hsa04062	0.33458669
87	Mineral absorption_Homo sapiens_hsa04978	0.32818944
88	Mismatch repair_Homo sapiens_hsa03430	0.32411596
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30871000
90	African trypanosomiasis_Homo sapiens_hsa05143	0.29813608
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26440987
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.24235684
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23615115
94	Thyroid cancer_Homo sapiens_hsa05216	0.23030530
95	Viral myocarditis_Homo sapiens_hsa05416	0.23030108
96	Morphine addiction_Homo sapiens_hsa05032	0.22502959
97	DNA replication_Homo sapiens_hsa03030	0.19360375
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.16128222
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.16110746
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.15980313

CHCHD2P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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