CHCHD2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.71063521
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.01616617
3DNA deamination (GO:0045006)5.89885858
4sequestering of actin monomers (GO:0042989)5.42137156
5valine metabolic process (GO:0006573)5.28825170
6protein prenylation (GO:0018342)5.27963961
7prenylation (GO:0097354)5.27963961
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23041568
9ATP synthesis coupled proton transport (GO:0015986)5.23041568
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.95397546
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.95397546
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94404183
13cytidine metabolic process (GO:0046087)4.80463517
14cytidine catabolic process (GO:0006216)4.80463517
15cytidine deamination (GO:0009972)4.80463517
16macroautophagy (GO:0016236)4.72316171
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57737486
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.36094542
19viral transcription (GO:0019083)4.26663562
20respiratory electron transport chain (GO:0022904)4.25405265
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.21133854
22protein complex biogenesis (GO:0070271)4.16578252
23electron transport chain (GO:0022900)4.15768142
24translational termination (GO:0006415)4.15107946
25positive regulation of interleukin-8 secretion (GO:2000484)4.11348694
26regulation of translation in response to stress (GO:0043555)4.00854488
27protein targeting to ER (GO:0045047)3.99158154
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.99063294
29mitochondrion transport along microtubule (GO:0047497)3.99063294
30branched-chain amino acid catabolic process (GO:0009083)3.97162327
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96496523
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.96028466
33sulfur amino acid catabolic process (GO:0000098)3.95821119
34cotranslational protein targeting to membrane (GO:0006613)3.95337331
35behavioral response to nicotine (GO:0035095)3.92847520
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80681291
37establishment of mitochondrion localization (GO:0051654)3.80348866
38protein localization to endoplasmic reticulum (GO:0070972)3.78800108
39mitochondrial respiratory chain complex assembly (GO:0033108)3.77799085
40translational elongation (GO:0006414)3.69194522
41L-methionine salvage (GO:0071267)3.69135622
42L-methionine biosynthetic process (GO:0071265)3.69135622
43amino acid salvage (GO:0043102)3.69135622
44mannosylation (GO:0097502)3.66848841
45protein neddylation (GO:0045116)3.61486160
46ribosomal large subunit biogenesis (GO:0042273)3.43689797
47ribosomal small subunit biogenesis (GO:0042274)3.43071554
48rRNA methylation (GO:0031167)3.40706054
49cardiovascular system development (GO:0072358)3.36084398
50rRNA modification (GO:0000154)3.34997134
51seminiferous tubule development (GO:0072520)3.33911379
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.28527349
53NADH dehydrogenase complex assembly (GO:0010257)3.28527349
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28527349
55L-fucose catabolic process (GO:0042355)3.26909610
56fucose catabolic process (GO:0019317)3.26909610
57L-fucose metabolic process (GO:0042354)3.26909610
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23269636
59oxidative phosphorylation (GO:0006119)3.19037304
60cellular protein complex disassembly (GO:0043624)3.18070315
61chaperone-mediated protein transport (GO:0072321)3.18022911
62viral life cycle (GO:0019058)3.17219662
63regulation of regulatory T cell differentiation (GO:0045589)3.16210229
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14997352
65RNA destabilization (GO:0050779)3.14705465
66GTP biosynthetic process (GO:0006183)3.12753313
67branched-chain amino acid metabolic process (GO:0009081)3.07464787
68cytochrome complex assembly (GO:0017004)3.06332836
69base-excision repair, AP site formation (GO:0006285)3.05866918
70ribosomal small subunit assembly (GO:0000028)3.03612099
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03290770
72cellular response to interferon-beta (GO:0035458)3.01298452
73regulation of chronic inflammatory response (GO:0002676)3.00466517
74regulation of interleukin-8 secretion (GO:2000482)2.97658889
75intracellular protein transmembrane import (GO:0044743)2.96873231
76maturation of 5.8S rRNA (GO:0000460)2.94605502
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92404953
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92404953
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91149621
80positive regulation of monocyte chemotaxis (GO:0090026)2.91078634
81actin nucleation (GO:0045010)2.91038961
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90750296
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90750296
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90750296
85maturation of SSU-rRNA (GO:0030490)2.88470796
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88284801
87positive regulation of defense response to virus by host (GO:0002230)2.87910162
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87718530
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86323512
90cytokinetic process (GO:0032506)2.84453702
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83539509
92hydrogen ion transmembrane transport (GO:1902600)2.82230781
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82084883
94translational initiation (GO:0006413)2.81742345
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.78556007
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78556007
97ATP biosynthetic process (GO:0006754)2.77977259
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.77334911
99interferon-gamma production (GO:0032609)2.75737563
100auditory behavior (GO:0031223)2.73085386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.58280429
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.23616811
3EZH2_22144423_ChIP-Seq_EOC_Human3.63667833
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.53241660
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.47766170
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.45796892
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27563469
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26578860
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13939089
10VDR_22108803_ChIP-Seq_LS180_Human2.91977695
11ZNF274_21170338_ChIP-Seq_K562_Hela2.79988783
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71651957
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32854648
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.31313413
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26224745
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22720070
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.19153834
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11140292
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.02034089
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99715021
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.96940148
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87291374
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83464068
24VDR_23849224_ChIP-Seq_CD4+_Human1.81264599
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72259291
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.68994286
27GBX2_23144817_ChIP-Seq_PC3_Human1.61461698
28AR_21572438_ChIP-Seq_LNCaP_Human1.59028300
29PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.49846781
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49845842
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48801867
32FOXP3_21729870_ChIP-Seq_TREG_Human1.48331638
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45414426
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.44880277
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43813648
36TP53_22573176_ChIP-Seq_HFKS_Human1.43118631
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40044967
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.38108551
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37820461
40MYC_18940864_ChIP-ChIP_HL60_Human1.36652472
41HTT_18923047_ChIP-ChIP_STHdh_Human1.33442483
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30356022
43SOX2_19829295_ChIP-Seq_ESCs_Human1.30332090
44NANOG_19829295_ChIP-Seq_ESCs_Human1.30332090
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26813383
46FUS_26573619_Chip-Seq_HEK293_Human1.26576156
47IRF1_19129219_ChIP-ChIP_H3396_Human1.24624613
48IGF1R_20145208_ChIP-Seq_DFB_Human1.24373090
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20791955
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.20403822
51RNF2_27304074_Chip-Seq_NSC_Mouse1.19373899
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17321286
53REST_21632747_ChIP-Seq_MESCs_Mouse1.15927060
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15816346
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15773951
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15650822
57ER_23166858_ChIP-Seq_MCF-7_Human1.15417358
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13497590
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13299395
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12922301
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.12922301
62EWS_26573619_Chip-Seq_HEK293_Human1.11159687
63AR_20517297_ChIP-Seq_VCAP_Human1.09316232
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.07892340
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06633759
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06089270
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.06060296
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05575347
69XRN2_22483619_ChIP-Seq_HELA_Human1.03232884
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02723169
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02253190
72NANOG_20526341_ChIP-Seq_ESCs_Human1.01335428
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00633797
74TAF2_19829295_ChIP-Seq_ESCs_Human1.00497650
75TAF15_26573619_Chip-Seq_HEK293_Human1.00114093
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99570566
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97597241
78JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96661570
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95900566
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95635327
81ERA_21632823_ChIP-Seq_H3396_Human0.95273696
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94872273
83P300_19829295_ChIP-Seq_ESCs_Human0.94714558
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94273219
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.94200214
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93684744
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92962874
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91896045
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91374297
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.90359576
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90224898
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89619289
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.88369955
94CBP_20019798_ChIP-Seq_JUKART_Human0.87384735
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87384735
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85424416
97TTF2_22483619_ChIP-Seq_HELA_Human0.84862405
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82670160
99NCOR_22424771_ChIP-Seq_293T_Human0.82260637
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81598188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.24805024
2MP0003646_muscle_fatigue4.57076686
3MP0002822_catalepsy3.15121631
4MP0002638_abnormal_pupillary_reflex3.01553238
5MP0005671_abnormal_response_to2.63268005
6MP0005423_abnormal_somatic_nervous2.40339313
7MP0004145_abnormal_muscle_electrophysio2.32870701
8MP0000569_abnormal_digit_pigmentation2.27005163
9MP0001529_abnormal_vocalization2.24089313
10MP0008058_abnormal_DNA_repair2.21123533
11MP0003880_abnormal_central_pattern2.14062137
12MP0005645_abnormal_hypothalamus_physiol2.01198512
13MP0001905_abnormal_dopamine_level1.96509750
14MP0002277_abnormal_respiratory_mucosa1.81391321
15MP0005551_abnormal_eye_electrophysiolog1.76549677
16MP0002234_abnormal_pharynx_morphology1.76090550
17MP0002938_white_spotting1.69313460
18MP0005623_abnormal_meninges_morphology1.59217601
19MP0002102_abnormal_ear_morphology1.56133860
20MP0006072_abnormal_retinal_apoptosis1.55443980
21MP0002837_dystrophic_cardiac_calcinosis1.54829139
22MP0002736_abnormal_nociception_after1.50222235
23MP0001919_abnormal_reproductive_system1.45342568
24MP0003136_yellow_coat_color1.45129734
25MP0006276_abnormal_autonomic_nervous1.37789955
26MP0003693_abnormal_embryo_hatching1.37636311
27MP0002095_abnormal_skin_pigmentation1.35738320
28MP0000750_abnormal_muscle_regeneration1.32028519
29MP0009785_altered_susceptibility_to1.29521440
30MP0000372_irregular_coat_pigmentation1.29145886
31MP0004742_abnormal_vestibular_system1.28801289
32MP0008872_abnormal_physiological_respon1.28236737
33MP0004142_abnormal_muscle_tone1.26705680
34MP0005397_hematopoietic_system_phenotyp1.24086612
35MP0001545_abnormal_hematopoietic_system1.24086612
36MP0009046_muscle_twitch1.20193302
37MP0009745_abnormal_behavioral_response1.19055425
38MP0001873_stomach_inflammation1.15674980
39MP0003011_delayed_dark_adaptation1.11912296
40MP0003137_abnormal_impulse_conducting1.10875679
41MP0004924_abnormal_behavior1.08503856
42MP0005386_behavior/neurological_phenoty1.08503856
43MP0003866_abnormal_defecation1.06514728
44MP0008789_abnormal_olfactory_epithelium1.05349048
45MP0008877_abnormal_DNA_methylation1.04842319
46MP0001485_abnormal_pinna_reflex1.01754186
47MP0005389_reproductive_system_phenotype1.01516991
48MP0000631_abnormal_neuroendocrine_gland1.00773748
49MP0002572_abnormal_emotion/affect_behav0.95607916
50MP0005636_abnormal_mineral_homeostasis0.95488239
51MP0004858_abnormal_nervous_system0.95314717
52MP0003718_maternal_effect0.95302482
53MP0006292_abnormal_olfactory_placode0.94830967
54MP0003195_calcinosis0.94826031
55MP0005646_abnormal_pituitary_gland0.93117732
56MP0004043_abnormal_pH_regulation0.93091540
57MP0001968_abnormal_touch/_nociception0.92756534
58MP0002272_abnormal_nervous_system0.92699757
59MP0003878_abnormal_ear_physiology0.92359094
60MP0005377_hearing/vestibular/ear_phenot0.92359094
61MP0004133_heterotaxia0.92066963
62MP0005195_abnormal_posterior_eye0.89438435
63MP0009250_abnormal_appendicular_skeleto0.88750750
64MP0009764_decreased_sensitivity_to0.87983989
65MP0002928_abnormal_bile_duct0.87329153
66MP0001790_abnormal_immune_system0.87171528
67MP0005387_immune_system_phenotype0.87171528
68MP0000566_synostosis0.86942329
69MP0008995_early_reproductive_senescence0.86657487
70MP0002163_abnormal_gland_morphology0.85231252
71MP0002067_abnormal_sensory_capabilities0.84175054
72MP0001501_abnormal_sleep_pattern0.82587112
73MP0001486_abnormal_startle_reflex0.82447359
74MP0008875_abnormal_xenobiotic_pharmacok0.81897439
75MP0005394_taste/olfaction_phenotype0.81168917
76MP0005499_abnormal_olfactory_system0.81168917
77MP0001188_hyperpigmentation0.80279316
78MP0002557_abnormal_social/conspecific_i0.77145396
79MP0003315_abnormal_perineum_morphology0.75802476
80MP0003786_premature_aging0.74192530
81MP0005253_abnormal_eye_physiology0.73725077
82MP0002909_abnormal_adrenal_gland0.73361228
83MP0002064_seizures0.72324422
84MP0005410_abnormal_fertilization0.71945346
85MP0009765_abnormal_xenobiotic_induced0.69925024
86MP0003698_abnormal_male_reproductive0.69579715
87MP0002210_abnormal_sex_determination0.69076150
88MP0002752_abnormal_somatic_nervous0.68879188
89MP0000026_abnormal_inner_ear0.68639857
90MP0002148_abnormal_hypersensitivity_rea0.67076696
91MP0003186_abnormal_redox_activity0.65100020
92MP0005379_endocrine/exocrine_gland_phen0.64660268
93MP0004147_increased_porphyrin_level0.64080232
94MP0002751_abnormal_autonomic_nervous0.61685436
95MP0006036_abnormal_mitochondrial_physio0.61435887
96MP0009053_abnormal_anal_canal0.61016841
97MP0002735_abnormal_chemical_nociception0.60710511
98MP0009333_abnormal_splenocyte_physiolog0.60565006
99MP0001119_abnormal_female_reproductive0.60401554
100MP0000534_abnormal_ureter_morphology0.60096612

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.81376325
2Pendular nystagmus (HP:0012043)4.79148373
3Decreased central vision (HP:0007663)4.69832213
4Type II lissencephaly (HP:0007260)4.48439258
5Increased hepatocellular lipid droplets (HP:0006565)4.42073896
6Acute necrotizing encephalopathy (HP:0006965)4.27670933
7Retinal dysplasia (HP:0007973)4.23787759
8Lipid accumulation in hepatocytes (HP:0006561)4.08810794
9Acanthocytosis (HP:0001927)4.01549613
10Abnormal rod and cone electroretinograms (HP:0008323)3.94667275
11Mitochondrial inheritance (HP:0001427)3.92797933
12Acute encephalopathy (HP:0006846)3.81199698
13Cerebral hypomyelination (HP:0006808)3.68173188
14Abnormal mitochondria in muscle tissue (HP:0008316)3.67621385
15Progressive macrocephaly (HP:0004481)3.60794983
16Renal Fanconi syndrome (HP:0001994)3.47399146
17Cerebellar dysplasia (HP:0007033)3.42422560
18Attenuation of retinal blood vessels (HP:0007843)3.38069097
19Increased CSF lactate (HP:0002490)3.36206615
20Personality changes (HP:0000751)3.29562218
21Disinhibition (HP:0000734)3.29225732
22Keratoconus (HP:0000563)3.24569128
23Increased corneal curvature (HP:0100692)3.24569128
24Increased intramyocellular lipid droplets (HP:0012240)3.19771032
25Hepatocellular necrosis (HP:0001404)3.09997177
26Acute hepatic failure (HP:0006554)2.98619271
27Renal cortical cysts (HP:0000803)2.97934917
28Retinal atrophy (HP:0001105)2.91866222
29Self-mutilation (HP:0000742)2.89363573
30Optic disc pallor (HP:0000543)2.87426659
31Hepatic necrosis (HP:0002605)2.86938463
32Abnormality of fatty-acid metabolism (HP:0004359)2.84634533
33Lissencephaly (HP:0001339)2.81469962
34Agitation (HP:0000713)2.72119648
35True hermaphroditism (HP:0010459)2.72006540
36Delayed CNS myelination (HP:0002188)2.68933646
37CNS hypomyelination (HP:0003429)2.68549181
38Hypoplasia of the pons (HP:0012110)2.67329512
39Increased muscle lipid content (HP:0009058)2.67009639
40Abolished electroretinogram (ERG) (HP:0000550)2.64591929
41Abnormality of the pons (HP:0007361)2.64325215
42Exertional dyspnea (HP:0002875)2.63082145
43Cerebral edema (HP:0002181)2.62225469
44Nephronophthisis (HP:0000090)2.57133028
45Pancreatic cysts (HP:0001737)2.56776211
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55032064
47Carpal bone hypoplasia (HP:0001498)2.52605235
48IgG deficiency (HP:0004315)2.45277337
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45198096
50Dyskinesia (HP:0100660)2.42388133
51Pancreatic fibrosis (HP:0100732)2.38731978
52Abnormal drinking behavior (HP:0030082)2.38473426
53Polydipsia (HP:0001959)2.38473426
54Pallor (HP:0000980)2.38358348
55Anencephaly (HP:0002323)2.36875990
56Medial flaring of the eyebrow (HP:0010747)2.28833553
57Hyperphosphaturia (HP:0003109)2.28762071
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27072049
59CNS demyelination (HP:0007305)2.25712301
60Abnormality of renal resorption (HP:0011038)2.23704763
61Abnormality of the renal cortex (HP:0011035)2.22210586
62Generalized aminoaciduria (HP:0002909)2.21082406
63Abnormality of midbrain morphology (HP:0002418)2.19812903
64Molar tooth sign on MRI (HP:0002419)2.19812903
65Choreoathetosis (HP:0001266)2.19564830
66Hyperglycinemia (HP:0002154)2.19484261
67Congenital, generalized hypertrichosis (HP:0004540)2.16138185
68Emotional lability (HP:0000712)2.10999486
69Severe muscular hypotonia (HP:0006829)2.10223518
70Aplastic anemia (HP:0001915)2.09787517
71Exercise intolerance (HP:0003546)2.08073590
72Respiratory failure (HP:0002878)2.05222111
73Abnormality of urine glucose concentration (HP:0011016)2.04814023
74Glycosuria (HP:0003076)2.04814023
75Hypoplasia of the brainstem (HP:0002365)2.03641328
76Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03641328
77Intellectual disability, profound (HP:0002187)2.03088129
78Pachygyria (HP:0001302)2.00643697
79Macular degeneration (HP:0000608)2.00488315
80Lethargy (HP:0001254)2.00212196
81Leukodystrophy (HP:0002415)1.95123768
82Increased serum lactate (HP:0002151)1.94033614
83Premature ovarian failure (HP:0008209)1.93091630
84Inappropriate behavior (HP:0000719)1.91732988
85Lactic acidosis (HP:0003128)1.91291769
86Unsteady gait (HP:0002317)1.88521460
87Brushfield spots (HP:0001088)1.88302293
88Hypothermia (HP:0002045)1.88251507
89Delusions (HP:0000746)1.87294980
90Abnormal albumin level (HP:0012116)1.85435312
91Hypoalbuminemia (HP:0003073)1.85435312
92Abnormality of the renal medulla (HP:0100957)1.84206470
93T lymphocytopenia (HP:0005403)1.83536390
94Decreased circulating renin level (HP:0003351)1.82219382
95Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81721556
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81604503
97Infantile muscular hypotonia (HP:0008947)1.80678069
98Limb hypertonia (HP:0002509)1.78517946
99Elevated erythrocyte sedimentation rate (HP:0003565)1.77324448
100Irregular epiphyses (HP:0010582)1.73185290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.54796360
2TXK3.36839049
3WNK33.23676761
4MAP4K12.97654322
5KDR2.71085585
6VRK22.68661446
7MAPK152.12740140
8BCKDK2.11561273
9PNCK2.01359052
10TAF11.95168804
11MARK31.93551428
12WNK41.88352508
13VRK11.79167085
14MAP4K21.77132607
15STK101.72770226
16SRPK11.68514259
17TSSK61.63630980
18GRK11.54696244
19MAP3K111.54675477
20ZAK1.52163003
21RIPK41.52161187
22ADRBK21.49181401
23GRK61.47952432
24EPHA31.43813946
25TLK11.43145031
26NTRK21.42670601
27TNIK1.42483868
28WEE11.41635832
29BUB11.29733710
30MAPK131.24011555
31DYRK21.22699208
32BMPR21.17974731
33FRK1.16123512
34NME11.14382984
35INSRR1.13391056
36PASK1.09170898
37MAP3K121.07978968
38OBSCN1.03993289
39ITK1.01135114
40PIM10.99378299
41LRRK20.99134045
42MUSK0.98997888
43NUAK10.97782647
44TAOK30.96005554
45RPS6KA50.94013561
46PKN10.93014330
47SYK0.90668554
48MARK10.88204939
49MST40.88014590
50TESK20.86411515
51BMPR1B0.85596985
52GRK70.83740317
53STK160.83203615
54PINK10.82213921
55OXSR10.79211412
56GRK50.77448691
57CAMK2A0.75682432
58STK110.75431230
59STK390.74764935
60PRKCG0.72885205
61CSNK1G30.72470283
62PRKACA0.71911554
63TRIM280.69426419
64PIK3CA0.64789693
65TEC0.63140734
66MAP3K40.61740311
67PRKCQ0.61695338
68KIT0.61658228
69BCR0.60858987
70PLK30.58035547
71LCK0.57144973
72ACVR1B0.55434879
73PLK20.54217413
74CCNB10.53226648
75CSNK2A10.53177169
76MAPKAPK50.51484253
77CSNK1A1L0.50417563
78CSNK1G20.50210180
79CSNK1G10.50136549
80CSK0.49315931
81CAMK10.48752546
82ADRBK10.48635790
83PRKCE0.48268463
84BLK0.47578880
85TESK10.47357450
86TGFBR10.46186433
87CSNK2A20.45752195
88CSNK1A10.44109698
89MINK10.42943827
90PRKCA0.42124180
91PIM20.41962465
92PHKG10.41937974
93PHKG20.41937974
94DAPK20.40366448
95TIE10.39357898
96LIMK10.38986823
97NTRK30.38385450
98ABL20.38323248
99ERBB30.37604976
100AURKA0.37342349

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.70624927
2Ribosome_Homo sapiens_hsa030104.10948219
3Parkinsons disease_Homo sapiens_hsa050123.91757613
4Proteasome_Homo sapiens_hsa030503.70760910
5Protein export_Homo sapiens_hsa030603.05350538
6Alzheimers disease_Homo sapiens_hsa050102.63987365
7Huntingtons disease_Homo sapiens_hsa050162.48683931
8Primary immunodeficiency_Homo sapiens_hsa053402.43374218
9Cardiac muscle contraction_Homo sapiens_hsa042602.38373458
10RNA polymerase_Homo sapiens_hsa030202.28034896
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26674437
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25760064
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25555355
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03501533
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83190344
16Graft-versus-host disease_Homo sapiens_hsa053321.81074358
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.57783000
18Sulfur relay system_Homo sapiens_hsa041221.45108562
19RNA degradation_Homo sapiens_hsa030181.39035727
20Autoimmune thyroid disease_Homo sapiens_hsa053201.33414616
21Antigen processing and presentation_Homo sapiens_hsa046121.29795149
22Type I diabetes mellitus_Homo sapiens_hsa049401.28511335
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26164339
24Allograft rejection_Homo sapiens_hsa053301.24086596
25Peroxisome_Homo sapiens_hsa041461.21722891
26Phototransduction_Homo sapiens_hsa047441.15619089
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14738548
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13565833
29Sulfur metabolism_Homo sapiens_hsa009201.10797397
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09125666
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07331080
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05774362
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05730351
34Butanoate metabolism_Homo sapiens_hsa006501.02304343
35Collecting duct acid secretion_Homo sapiens_hsa049661.01262236
36Nicotine addiction_Homo sapiens_hsa050331.01046719
37Fatty acid elongation_Homo sapiens_hsa000621.00602162
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93139597
39Hematopoietic cell lineage_Homo sapiens_hsa046400.90663649
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.90335463
41Olfactory transduction_Homo sapiens_hsa047400.88520352
42Rheumatoid arthritis_Homo sapiens_hsa053230.85670925
43Pyrimidine metabolism_Homo sapiens_hsa002400.84937406
44Retinol metabolism_Homo sapiens_hsa008300.83726680
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83266195
46Purine metabolism_Homo sapiens_hsa002300.83262278
47Tryptophan metabolism_Homo sapiens_hsa003800.78171720
48Basal transcription factors_Homo sapiens_hsa030220.77263183
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74749540
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74010391
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72856047
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70439938
53Asthma_Homo sapiens_hsa053100.68619492
54Metabolic pathways_Homo sapiens_hsa011000.68317297
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68260921
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.66144128
57Linoleic acid metabolism_Homo sapiens_hsa005910.64519080
58Selenocompound metabolism_Homo sapiens_hsa004500.63258714
59Folate biosynthesis_Homo sapiens_hsa007900.63120195
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.62744272
61Chemical carcinogenesis_Homo sapiens_hsa052040.60550589
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59969792
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59441449
64Tyrosine metabolism_Homo sapiens_hsa003500.57414359
65Caffeine metabolism_Homo sapiens_hsa002320.56019684
66Morphine addiction_Homo sapiens_hsa050320.55959965
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55821710
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55818453
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55052188
70Nitrogen metabolism_Homo sapiens_hsa009100.54952065
71Insulin secretion_Homo sapiens_hsa049110.52576054
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52389014
73Taste transduction_Homo sapiens_hsa047420.51248337
74Mineral absorption_Homo sapiens_hsa049780.50473599
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47877471
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47400055
77T cell receptor signaling pathway_Homo sapiens_hsa046600.45630012
78Base excision repair_Homo sapiens_hsa034100.45173274
79Fanconi anemia pathway_Homo sapiens_hsa034600.44289682
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43924280
81GABAergic synapse_Homo sapiens_hsa047270.43445165
82Cocaine addiction_Homo sapiens_hsa050300.43273081
83Propanoate metabolism_Homo sapiens_hsa006400.43193278
84ABC transporters_Homo sapiens_hsa020100.42816764
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.41818834
86Phagosome_Homo sapiens_hsa041450.41596556
87Mismatch repair_Homo sapiens_hsa034300.39105030
88beta-Alanine metabolism_Homo sapiens_hsa004100.38480715
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.37982157
90Histidine metabolism_Homo sapiens_hsa003400.34739221
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33222057
92DNA replication_Homo sapiens_hsa030300.33168574
93RNA transport_Homo sapiens_hsa030130.31157456
94Fatty acid degradation_Homo sapiens_hsa000710.30849733
95Nucleotide excision repair_Homo sapiens_hsa034200.30746441
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29730045
97Spliceosome_Homo sapiens_hsa030400.28560527
98One carbon pool by folate_Homo sapiens_hsa006700.28558529
99Homologous recombination_Homo sapiens_hsa034400.27491311
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27421899

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