ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of oxidative phosphorylation (GO:0002082)	6.50525997
2	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.91644495
3	positive regulation of prostaglandin secretion (GO:0032308)	5.61825994
4	ATP synthesis coupled proton transport (GO:0015986)	5.57274248
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.57274248
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.20741562
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.66541012
8	urate metabolic process (GO:0046415)	4.64633423
9	respiratory electron transport chain (GO:0022904)	4.62722392
10	electron transport chain (GO:0022900)	4.58251366
11	regulation of prostaglandin secretion (GO:0032306)	4.50364547
12	regulation of hexokinase activity (GO:1903299)	4.39197383
13	regulation of glucokinase activity (GO:0033131)	4.39197383
14	oxidative phosphorylation (GO:0006119)	4.36142666
15	protein-cofactor linkage (GO:0018065)	4.21754166
16	maturation of SSU-rRNA (GO:0030490)	4.21685890
17	positive regulation of protein homodimerization activity (GO:0090073)	4.00692179
18	vagina development (GO:0060068)	3.89394560
19	regulation of cilium movement (GO:0003352)	3.78296104
20	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	3.70811670
21	female genitalia development (GO:0030540)	3.66886771
22	cerebellar Purkinje cell differentiation (GO:0021702)	3.63761531
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.61680057
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.61680057
25	aldehyde catabolic process (GO:0046185)	3.60034388
26	positive regulation of icosanoid secretion (GO:0032305)	3.59152424
27	ribosomal small subunit assembly (GO:0000028)	3.57024337
28	intra-S DNA damage checkpoint (GO:0031573)	3.51264854
29	positive regulation of fatty acid transport (GO:2000193)	3.50749737
30	endoderm formation (GO:0001706)	3.48385394
31	removal of superoxide radicals (GO:0019430)	3.48059492
32	cellular response to superoxide (GO:0071451)	3.48059492
33	cellular response to oxygen radical (GO:0071450)	3.48059492
34	inner ear receptor cell differentiation (GO:0060113)	3.47635066
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.46053347
36	regulation of cellular respiration (GO:0043457)	3.45142810
37	male meiosis I (GO:0007141)	3.40721018
38	tyrosine metabolic process (GO:0006570)	3.36471943
39	negative regulation of sterol transport (GO:0032372)	3.34925244
40	negative regulation of cholesterol transport (GO:0032375)	3.34925244
41	DNA double-strand break processing (GO:0000729)	3.33320127
42	cellular respiration (GO:0045333)	3.29290869
43	somite rostral/caudal axis specification (GO:0032525)	3.21150432
44	glyoxylate metabolic process (GO:0046487)	3.17597586
45	ribosomal large subunit biogenesis (GO:0042273)	3.15969754
46	chaperone-mediated protein transport (GO:0072321)	3.15546672
47	phospholipid efflux (GO:0033700)	3.14852415
48	regulation of cholesterol esterification (GO:0010872)	3.14262057
49	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.14128370
50	hydrogen ion transmembrane transport (GO:1902600)	3.13966265
51	protein complex biogenesis (GO:0070271)	3.09340427
52	prenylation (GO:0097354)	3.05435658
53	protein prenylation (GO:0018342)	3.05435658
54	head development (GO:0060322)	3.05084164
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04734926
56	NADH dehydrogenase complex assembly (GO:0010257)	3.04734926
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04734926
58	hyperosmotic salinity response (GO:0042538)	3.04678554
59	aerobic respiration (GO:0009060)	3.04244223
60	cellular response to zinc ion (GO:0071294)	3.03655056
61	4-hydroxyproline metabolic process (GO:0019471)	3.02528254
62	myoblast migration (GO:0051451)	3.01015342
63	response to pheromone (GO:0019236)	2.98893819
64	proteasome assembly (GO:0043248)	2.96432939
65	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.95884126
66	ATP biosynthetic process (GO:0006754)	2.93444098
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.92985351
68	termination of RNA polymerase III transcription (GO:0006386)	2.92985351
69	proton transport (GO:0015992)	2.90593375
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89704997
71	pyrimidine nucleobase catabolic process (GO:0006208)	2.86937079
72	defense response to fungus (GO:0050832)	2.85085736
73	signal transduction involved in regulation of gene expression (GO:0023019)	2.84471931
74	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84169799
75	respiratory chain complex IV assembly (GO:0008535)	2.81762951
76	piRNA metabolic process (GO:0034587)	2.80980178
77	hydrogen transport (GO:0006818)	2.80930780
78	regulation of penile erection (GO:0060405)	2.80174392
79	regulation of cardioblast differentiation (GO:0051890)	2.78884712
80	DNA methylation involved in gamete generation (GO:0043046)	2.78781628
81	signal peptide processing (GO:0006465)	2.78626819
82	drinking behavior (GO:0042756)	2.74577459
83	glycerophospholipid catabolic process (GO:0046475)	2.73819797
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.72052073
85	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.69921041
86	negative regulation of response to reactive oxygen species (GO:1901032)	2.69535864
87	high-density lipoprotein particle remodeling (GO:0034375)	2.67559035
88	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66471540
89	meiosis I (GO:0007127)	2.66463286
90	very-low-density lipoprotein particle assembly (GO:0034379)	2.65614236
91	glycerol ether metabolic process (GO:0006662)	2.65273365
92	otic vesicle formation (GO:0030916)	2.65167178
93	dopamine transport (GO:0015872)	2.64213827
94	L-serine metabolic process (GO:0006563)	2.63238907
95	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62642918
96	L-fucose catabolic process (GO:0042355)	2.62152645
97	fucose catabolic process (GO:0019317)	2.62152645
98	L-fucose metabolic process (GO:0042354)	2.62152645
99	nucleobase catabolic process (GO:0046113)	2.61708448
100	protein neddylation (GO:0045116)	2.61377963

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.84817856
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.39280884
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.69354123
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59895154
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.40240073
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.24895060
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09407766
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.91047611
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.80827852
10	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.78562324
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.74155739
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72693788
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72164496
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68631034
15	VDR_22108803_ChIP-Seq_LS180_Human	2.51641731
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.35767941
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.32386601
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29813451
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.21353737
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.14966877
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.90036371
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84011120
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.76592120
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.75554843
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73326536
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70778337
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.67009212
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66876871
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66296987
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59473871
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.58455818
32	EWS_26573619_Chip-Seq_HEK293_Human	1.54370434
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48738103
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47318363
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46503222
36	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.45407995
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.45302442
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41575489
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40319472
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.35801563
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34799710
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34647824
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34071900
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.30511269
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25616336
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.25517842
47	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.23492157
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23202270
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.22511642
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22118992
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.20978374
52	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.19628416
53	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.19473230
54	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.16405317
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16103750
56	ELF5_23300383_ChIP-Seq_T47D_Human	1.15850388
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13621058
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.13545461
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11656066
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.09763558
61	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.07358319
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06515614
63	NCOR_22424771_ChIP-Seq_293T_Human	1.05576935
64	AR_21909140_ChIP-Seq_LNCAP_Human	1.05096414
65	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.04496881
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04426834
67	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.03827905
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01796219
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01796219
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00678592
71	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99644814
72	MYC_19829295_ChIP-Seq_ESCs_Human	0.98607184
73	P300_19829295_ChIP-Seq_ESCs_Human	0.98215751
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98147403
75	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.97883320
76	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96678652
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96590254
78	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96217791
79	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94930790
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94742061
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94353145
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94014432
83	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93842439
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92511121
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.92225512
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92200905
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91704436
88	ERA_21632823_ChIP-Seq_H3396_Human	0.90391479
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.90306336
90	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.89637483
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89390367
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89390367
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89019206
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88837971
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.86698389
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86541719
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86311861
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85055258
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83859429
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.82697638

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.92664861
2	MP0001485_abnormal_pinna_reflex	3.69474101
3	MP0004742_abnormal_vestibular_system	3.53114278
4	MP0008872_abnormal_physiological_respon	3.35111469
5	MP0002254_reproductive_system_inflammat	3.25213808
6	MP0002909_abnormal_adrenal_gland	2.95809482
7	MP0003890_abnormal_embryonic-extraembry	2.88870218
8	MP0003195_calcinosis	2.88015524
9	MP0005171_absent_coat_pigmentation	2.74917567
10	MP0008877_abnormal_DNA_methylation	2.70545333
11	MP0003806_abnormal_nucleotide_metabolis	2.50409063
12	MP0001968_abnormal_touch/_nociception	2.48623799
13	MP0000372_irregular_coat_pigmentation	2.42290457
14	MP0002736_abnormal_nociception_after	2.28414247
15	MP0005360_urolithiasis	2.28369519
16	MP0002138_abnormal_hepatobiliary_system	2.24708497
17	MP0001529_abnormal_vocalization	2.22871883
18	MP0006292_abnormal_olfactory_placode	2.22213814
19	MP0003186_abnormal_redox_activity	1.93086876
20	MP0000569_abnormal_digit_pigmentation	1.93058253
21	MP0005084_abnormal_gallbladder_morpholo	1.91420794
22	MP0002277_abnormal_respiratory_mucosa	1.82667873
23	MP0002837_dystrophic_cardiac_calcinosis	1.81875172
24	MP0003880_abnormal_central_pattern	1.76442971
25	MP0010386_abnormal_urinary_bladder	1.75884071
26	MP0003693_abnormal_embryo_hatching	1.66693958
27	MP0008875_abnormal_xenobiotic_pharmacok	1.64579095
28	MP0005503_abnormal_tendon_morphology	1.59459059
29	MP0006276_abnormal_autonomic_nervous	1.52061587
30	MP0001919_abnormal_reproductive_system	1.48325101
31	MP0005499_abnormal_olfactory_system	1.43350114
32	MP0005394_taste/olfaction_phenotype	1.43350114
33	MP0008789_abnormal_olfactory_epithelium	1.41423952
34	MP0001963_abnormal_hearing_physiology	1.37871655
35	MP0004133_heterotaxia	1.37179422
36	MP0005645_abnormal_hypothalamus_physiol	1.35017391
37	MP0001986_abnormal_taste_sensitivity	1.32591444
38	MP0003718_maternal_effect	1.29508670
39	MP0005410_abnormal_fertilization	1.28867219
40	MP0003763_abnormal_thymus_physiology	1.25537271
41	MP0009333_abnormal_splenocyte_physiolog	1.24636376
42	MP0005551_abnormal_eye_electrophysiolog	1.20712206
43	MP0000639_abnormal_adrenal_gland	1.19248264
44	MP0005389_reproductive_system_phenotype	1.17651801
45	MP0005670_abnormal_white_adipose	1.16653847
46	MP0001905_abnormal_dopamine_level	1.14496410
47	MP0000230_abnormal_systemic_arterial	1.13736988
48	MP0009697_abnormal_copulation	1.13537945
49	MP0005636_abnormal_mineral_homeostasis	1.12178063
50	MP0002163_abnormal_gland_morphology	1.11914533
51	MP0005085_abnormal_gallbladder_physiolo	1.09374159
52	MP0003123_paternal_imprinting	1.08034274
53	MP0009745_abnormal_behavioral_response	1.07798239
54	MP0003567_abnormal_fetal_cardiomyocyte	1.03296161
55	MP0003938_abnormal_ear_development	1.03184564
56	MP0005167_abnormal_blood-brain_barrier	1.02526261
57	MP0003119_abnormal_digestive_system	1.02000996
58	MP0003786_premature_aging	1.01037689
59	MP0004147_increased_porphyrin_level	0.97843772
60	MP0006072_abnormal_retinal_apoptosis	0.95873292
61	MP0000015_abnormal_ear_pigmentation	0.95051342
62	MP0001984_abnormal_olfaction	0.94374147
63	MP0000371_diluted_coat_color	0.93429287
64	MP0008438_abnormal_cutaneous_collagen	0.92699363
65	MP0001188_hyperpigmentation	0.92558584
66	MP0001440_abnormal_grooming_behavior	0.92520050
67	MP0002751_abnormal_autonomic_nervous	0.92014116
68	MP0004957_abnormal_blastocyst_morpholog	0.91719163
69	MP0005377_hearing/vestibular/ear_phenot	0.91115503
70	MP0003878_abnormal_ear_physiology	0.91115503
71	MP0003941_abnormal_skin_development	0.88630360
72	MP0000538_abnormal_urinary_bladder	0.87117833
73	MP0001929_abnormal_gametogenesis	0.85009059
74	MP0005584_abnormal_enzyme/coenzyme_acti	0.84010769
75	MP0000427_abnormal_hair_cycle	0.82474434
76	MP0002272_abnormal_nervous_system	0.81590061
77	MP0003936_abnormal_reproductive_system	0.78695860
78	MP0001502_abnormal_circadian_rhythm	0.78199627
79	MP0010094_abnormal_chromosome_stability	0.78052128
80	MP0009780_abnormal_chondrocyte_physiolo	0.77513722
81	MP0005174_abnormal_tail_pigmentation	0.77034069
82	MP0001873_stomach_inflammation	0.76168479
83	MP0006036_abnormal_mitochondrial_physio	0.74083861
84	MP0003638_abnormal_response/metabolism_	0.72921367
85	MP0003385_abnormal_body_wall	0.72830047
86	MP0005379_endocrine/exocrine_gland_phen	0.72465968
87	MP0002210_abnormal_sex_determination	0.72345345
88	MP0009384_cardiac_valve_regurgitation	0.71097606
89	MP0008058_abnormal_DNA_repair	0.69960088
90	MP0001881_abnormal_mammary_gland	0.68760449
91	MP0001765_abnormal_ion_homeostasis	0.68529834
92	MP0002067_abnormal_sensory_capabilities	0.67810687
93	MP0003866_abnormal_defecation	0.66906550
94	MP0002064_seizures	0.65507546
95	MP0004215_abnormal_myocardial_fiber	0.65210042
96	MP0005266_abnormal_metabolism	0.64124288
97	MP0001970_abnormal_pain_threshold	0.64005994
98	MP0001145_abnormal_male_reproductive	0.62910893
99	MP0002160_abnormal_reproductive_system	0.62790992
100	MP0003698_abnormal_male_reproductive	0.62169676

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.18897240
2	Mitochondrial inheritance (HP:0001427)	4.57759518
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.42774049
4	Acute encephalopathy (HP:0006846)	4.27724846
5	Increased CSF lactate (HP:0002490)	4.26821242
6	Progressive macrocephaly (HP:0004481)	4.25110589
7	Hepatocellular necrosis (HP:0001404)	4.18437430
8	Abnormal pancreas size (HP:0012094)	4.09044988
9	Congenital, generalized hypertrichosis (HP:0004540)	3.91303178
10	Hypomagnesemia (HP:0002917)	3.81671955
11	Hypothermia (HP:0002045)	3.65608134
12	Multiple enchondromatosis (HP:0005701)	3.50257986
13	Increased hepatocellular lipid droplets (HP:0006565)	3.49454941
14	3-Methylglutaconic aciduria (HP:0003535)	3.43197872
15	Cerebral edema (HP:0002181)	3.37575632
16	Hepatic necrosis (HP:0002605)	3.36005740
17	Lipid accumulation in hepatocytes (HP:0006561)	3.33743394
18	Abnormality of magnesium homeostasis (HP:0004921)	3.24332487
19	Renal cortical cysts (HP:0000803)	2.96346561
20	Hyperglycinemia (HP:0002154)	2.92647654
21	Conjunctival telangiectasia (HP:0000524)	2.91309955
22	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.84097299
23	Renal Fanconi syndrome (HP:0001994)	2.79621290
24	Leukodystrophy (HP:0002415)	2.79194340
25	Aplasia/hypoplasia of the humerus (HP:0006507)	2.73734444
26	Anomalous pulmonary venous return (HP:0010772)	2.71928013
27	Optic disc pallor (HP:0000543)	2.63056347
28	Respiratory failure (HP:0002878)	2.60431041
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.57096113
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.56420203
31	Colon cancer (HP:0003003)	2.54611261
32	Paralysis (HP:0003470)	2.50755840
33	Increased serum lactate (HP:0002151)	2.50727011
34	Abnormality of B cell number (HP:0010975)	2.47374845
35	Pendular nystagmus (HP:0012043)	2.46350017
36	Microvesicular hepatic steatosis (HP:0001414)	2.40953525
37	Hypokalemic alkalosis (HP:0001949)	2.39348938
38	Double outlet right ventricle (HP:0001719)	2.37798161
39	Congenital malformation of the right heart (HP:0011723)	2.37798161
40	Abnormality of urine glucose concentration (HP:0011016)	2.37375705
41	Glycosuria (HP:0003076)	2.37375705
42	Cerebral palsy (HP:0100021)	2.35422490
43	Abnormality of the pulmonary veins (HP:0011718)	2.35343401
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31796833
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.31796833
46	Tetany (HP:0001281)	2.30340221
47	Abnormality of the renal cortex (HP:0011035)	2.28561360
48	Abnormality of serine family amino acid metabolism (HP:0010894)	2.26641365
49	Abnormality of glycine metabolism (HP:0010895)	2.26641365
50	Polyuria (HP:0000103)	2.26550742
51	Woolly hair (HP:0002224)	2.25515811
52	Alkalosis (HP:0001948)	2.22979140
53	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.21668910
54	Cleft eyelid (HP:0000625)	2.19329361
55	Aplasia of the musculature (HP:0100854)	2.16602245
56	Abnormality of the ileum (HP:0001549)	2.16374332
57	Hypoplasia of the radius (HP:0002984)	2.15102039
58	Respiratory difficulties (HP:0002880)	2.13290301
59	Carpal bone hypoplasia (HP:0001498)	2.11734667
60	Type 2 muscle fiber atrophy (HP:0003554)	2.10230350
61	Delayed CNS myelination (HP:0002188)	2.10029336
62	Pancreatic cysts (HP:0001737)	2.09371791
63	Disproportionate short-trunk short stature (HP:0003521)	2.08164637
64	CNS demyelination (HP:0007305)	2.07541836
65	Abnormality of the labia minora (HP:0012880)	2.07011492
66	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06668622
67	B lymphocytopenia (HP:0010976)	2.01937751
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.01892491
69	Abnormality of the aortic arch (HP:0012303)	2.01638234
70	Increased intramyocellular lipid droplets (HP:0012240)	2.00281751
71	Conical tooth (HP:0000698)	1.96795215
72	Meckel diverticulum (HP:0002245)	1.93391523
73	Hyperglycinuria (HP:0003108)	1.91916081
74	Polydipsia (HP:0001959)	1.91561320
75	Abnormal drinking behavior (HP:0030082)	1.91561320
76	Abnormality of the parathyroid morphology (HP:0011766)	1.90779840
77	Hypophosphatemic rickets (HP:0004912)	1.90685099
78	Short humerus (HP:0005792)	1.90097958
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88143854
80	Keratoconus (HP:0000563)	1.87486337
81	Increased corneal curvature (HP:0100692)	1.87486337
82	Hypoplastic left heart (HP:0004383)	1.87258825
83	Lactic acidosis (HP:0003128)	1.86859120
84	Abnormality of renin-angiotensin system (HP:0000847)	1.86066015
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84942334
86	Abnormality of alanine metabolism (HP:0010916)	1.84942334
87	Hyperalaninemia (HP:0003348)	1.84942334
88	Bell-shaped thorax (HP:0001591)	1.84653203
89	Methylmalonic aciduria (HP:0012120)	1.84381690
90	Methylmalonic acidemia (HP:0002912)	1.84349785
91	Lethargy (HP:0001254)	1.83374074
92	Renal salt wasting (HP:0000127)	1.82999190
93	Exercise intolerance (HP:0003546)	1.82168492
94	Abnormal urine output (HP:0012590)	1.81373447
95	Stomatitis (HP:0010280)	1.80957897
96	Cerebellar dysplasia (HP:0007033)	1.80826925
97	Increased circulating renin level (HP:0000848)	1.80550075
98	Hyperventilation (HP:0002883)	1.79491712
99	Spontaneous hematomas (HP:0007420)	1.79210448
100	Chronic bronchitis (HP:0004469)	1.77424561

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.79972526
2	NEK2	3.63507299
3	SCYL2	3.60802218
4	SRPK1	3.42746490
5	TXK	3.32260972
6	SIK2	3.16224278
7	MST4	3.06872584
8	WNK3	3.04035236
9	STK39	3.03561258
10	VRK2	3.02491460
11	PDK2	2.99761339
12	PBK	2.99692605
13	TLK1	2.71593402
14	TSSK6	2.43059828
15	STK16	2.40881105
16	OXSR1	2.40431807
17	MAP4K1	2.36608287
18	NEK1	2.17826359
19	BUB1	1.82501020
20	ZAK	1.61318754
21	LIMK1	1.53964545
22	STK3	1.43702756
23	TNIK	1.43372405
24	FRK	1.35517832
25	TESK1	1.31509020
26	NME2	1.27236316
27	CAMKK2	1.23764271
28	BMX	1.21304783
29	WEE1	1.15821516
30	MKNK2	1.12843582
31	TNK2	1.08098882
32	MAP3K9	1.07768229
33	TAF1	1.06199166
34	STK4	1.06137056
35	NUAK1	1.05873583
36	MAP2K7	0.98533073
37	DYRK2	0.98499906
38	GRK1	0.95409361
39	PAK3	0.92282008
40	NLK	0.90957953
41	BMPR2	0.87805677
42	ADRBK2	0.87458481
43	MAP4K2	0.86348690
44	STK10	0.85999815
45	VRK1	0.84888576
46	MKNK1	0.84184646
47	CDK8	0.69581434
48	MAP3K4	0.68057546
49	BRSK2	0.66037560
50	MAP3K12	0.62982001
51	NME1	0.59917242
52	PKN1	0.59359530
53	PLK3	0.55387434
54	INSRR	0.53569876
55	BTK	0.53026277
56	MAPK15	0.48234172
57	CAMKK1	0.46669002
58	TEC	0.46636103
59	ALK	0.44860483
60	CSNK2A2	0.41913077
61	PLK4	0.40149465
62	TIE1	0.39583585
63	ADRBK1	0.39062717
64	NEK9	0.39025578
65	IKBKB	0.38385699
66	CSNK2A1	0.36325170
67	BCKDK	0.36249504
68	LYN	0.35616767
69	ABL2	0.33271331
70	CHEK2	0.31399299
71	PLK1	0.30783508
72	PLK2	0.29091790
73	LATS1	0.28901613
74	SIK3	0.28009362
75	PRKCG	0.26035362
76	AURKB	0.24459171
77	FGFR2	0.23979353
78	PAK6	0.23625520
79	MAP3K8	0.23529254
80	OBSCN	0.23437083
81	CAMK1	0.23120786
82	PRKACA	0.22796098
83	PRKD3	0.21511773
84	LRRK2	0.21074529
85	PRKCA	0.20669950
86	DMPK	0.19849280
87	TTK	0.19422626
88	CSNK1G2	0.18913324
89	SYK	0.18656768
90	FGFR1	0.18550893
91	ABL1	0.18472536
92	EPHA4	0.18367735
93	RPS6KA5	0.18293745
94	CDK3	0.18105415
95	PRKCD	0.15077105
96	FLT3	0.14923656
97	PRKCQ	0.14368747
98	PHKG1	0.13728551
99	PHKG2	0.13728551
100	CAMK2A	0.13118490

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.66600370
2	Proteasome_Homo sapiens_hsa03050	4.12075538
3	Parkinsons disease_Homo sapiens_hsa05012	4.05048992
4	Huntingtons disease_Homo sapiens_hsa05016	3.05730750
5	Ribosome_Homo sapiens_hsa03010	3.00586893
6	Alzheimers disease_Homo sapiens_hsa05010	2.64817458
7	Homologous recombination_Homo sapiens_hsa03440	2.49790647
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.49262864
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44527225
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43159197
11	Protein export_Homo sapiens_hsa03060	2.26662417
12	RNA polymerase_Homo sapiens_hsa03020	2.26271868
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.13784364
14	DNA replication_Homo sapiens_hsa03030	1.97463185
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.85852207
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.80724634
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77610014
18	Caffeine metabolism_Homo sapiens_hsa00232	1.70931593
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65442326
20	Base excision repair_Homo sapiens_hsa03410	1.59125773
21	Sulfur metabolism_Homo sapiens_hsa00920	1.56752623
22	Phototransduction_Homo sapiens_hsa04744	1.56127633
23	Mismatch repair_Homo sapiens_hsa03430	1.51230154
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.39031258
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.34496250
26	Propanoate metabolism_Homo sapiens_hsa00640	1.30863747
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.30723418
28	RNA degradation_Homo sapiens_hsa03018	1.29291163
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23132534
30	One carbon pool by folate_Homo sapiens_hsa00670	1.18532916
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.17420975
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16736355
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14050270
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13960810
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13723621
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13367433
37	Basal transcription factors_Homo sapiens_hsa03022	1.13137862
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.13073919
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08668569
40	Spliceosome_Homo sapiens_hsa03040	1.03614026
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.00929403
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00417798
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99368275
44	Glutathione metabolism_Homo sapiens_hsa00480	0.99308419
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97283158
46	Mineral absorption_Homo sapiens_hsa04978	0.97091810
47	Peroxisome_Homo sapiens_hsa04146	0.96727371
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95769771
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92028934
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.90335530
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86713075
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85419347
53	Asthma_Homo sapiens_hsa05310	0.81928426
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80180145
55	Purine metabolism_Homo sapiens_hsa00230	0.80093774
56	Metabolic pathways_Homo sapiens_hsa01100	0.77990540
57	Fatty acid degradation_Homo sapiens_hsa00071	0.77973176
58	RNA transport_Homo sapiens_hsa03013	0.76326803
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75054932
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.73555240
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69375405
62	Retinol metabolism_Homo sapiens_hsa00830	0.68669228
63	Nicotine addiction_Homo sapiens_hsa05033	0.68268753
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66258629
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.65225374
66	Histidine metabolism_Homo sapiens_hsa00340	0.63815374
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62232644
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58916031
69	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.55739036
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.53280452
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50383186
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48114806
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45983085
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45374028
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44551165
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41490330
77	Butanoate metabolism_Homo sapiens_hsa00650	0.38538510
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34306526
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33863428
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31741132
81	Sulfur relay system_Homo sapiens_hsa04122	0.31510841
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.30891604
83	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.27707459
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27580083
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.26958805
86	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26804006
87	Morphine addiction_Homo sapiens_hsa05032	0.25978128
88	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.25263774
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.25244689
90	Olfactory transduction_Homo sapiens_hsa04740	0.25055609
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24577998
92	Serotonergic synapse_Homo sapiens_hsa04726	0.24409038
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.23509670
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.22654091
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.22191059
96	GABAergic synapse_Homo sapiens_hsa04727	0.20918096
97	Taste transduction_Homo sapiens_hsa04742	0.19856704
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.18535567
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.17575840
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17574748

CHCHD2P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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