CHCHD2P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.10862504
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.65869556
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.52268708
4ATP synthesis coupled proton transport (GO:0015986)6.52268708
5chaperone-mediated protein transport (GO:0072321)6.17692776
6ribosomal small subunit biogenesis (GO:0042274)6.00275586
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.63093970
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.57532325
9ribosomal small subunit assembly (GO:0000028)5.48858775
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.45051435
11respiratory electron transport chain (GO:0022904)5.41231672
12maturation of SSU-rRNA (GO:0030490)5.37320366
13electron transport chain (GO:0022900)5.28596849
14cytidine deamination (GO:0009972)5.27961040
15cytidine metabolic process (GO:0046087)5.27961040
16cytidine catabolic process (GO:0006216)5.27961040
17viral transcription (GO:0019083)4.77716323
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.76529783
19translational termination (GO:0006415)4.57653270
20protein complex biogenesis (GO:0070271)4.52094177
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37145857
22mitochondrial respiratory chain complex assembly (GO:0033108)4.35616404
23protein targeting to ER (GO:0045047)4.33431074
24cotranslational protein targeting to membrane (GO:0006613)4.30403790
25translational elongation (GO:0006414)4.30397435
26proteasome assembly (GO:0043248)4.29706747
27respiratory chain complex IV assembly (GO:0008535)4.18381784
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.17129408
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13172586
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.13172586
31NADH dehydrogenase complex assembly (GO:0010257)4.13172586
32protein localization to endoplasmic reticulum (GO:0070972)4.10598797
33protein targeting to mitochondrion (GO:0006626)4.04967135
34ATP biosynthetic process (GO:0006754)3.99566857
35translation (GO:0006412)3.98462006
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98406632
37establishment of protein localization to mitochondrion (GO:0072655)3.94764053
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.92388566
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.87285908
40cytochrome complex assembly (GO:0017004)3.85345250
41viral life cycle (GO:0019058)3.79719027
42hydrogen ion transmembrane transport (GO:1902600)3.78575896
43pseudouridine synthesis (GO:0001522)3.78370435
44cellular component biogenesis (GO:0044085)3.74401937
45GTP biosynthetic process (GO:0006183)3.69657312
46ubiquinone biosynthetic process (GO:0006744)3.69508526
47sequestering of actin monomers (GO:0042989)3.68720358
48ribonucleoprotein complex biogenesis (GO:0022613)3.68310194
49regulation of cellular amino acid metabolic process (GO:0006521)3.67857399
50protein localization to mitochondrion (GO:0070585)3.65728696
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64376490
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58749978
53translational initiation (GO:0006413)3.52286132
54regulation of mitochondrial translation (GO:0070129)3.51194512
55cellular protein complex disassembly (GO:0043624)3.49581571
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46754039
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46754039
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46754039
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.46119346
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.46119346
612-deoxyribonucleotide biosynthetic process (GO:0009265)3.45744742
62deoxyribose phosphate biosynthetic process (GO:0046385)3.45744742
63deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.42628513
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.42514702
65proton transport (GO:0015992)3.42474256
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37463004
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37463004
68negative regulation of ligase activity (GO:0051352)3.36492786
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36492786
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.34410236
71ubiquinone metabolic process (GO:0006743)3.34407827
72hydrogen transport (GO:0006818)3.34087399
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33969577
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.33969577
75ribosomal large subunit biogenesis (GO:0042273)3.32835566
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30156438
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.29678880
78rRNA modification (GO:0000154)3.28250069
79transcription elongation from RNA polymerase III promoter (GO:0006385)3.25974478
80termination of RNA polymerase III transcription (GO:0006386)3.25974478
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25292151
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25222026
83behavioral response to nicotine (GO:0035095)3.19430667
84protein neddylation (GO:0045116)3.18636158
85cellular response to interferon-beta (GO:0035458)3.17119240
86mitochondrial transport (GO:0006839)3.14547038
87UTP biosynthetic process (GO:0006228)3.13971308
88nucleoside triphosphate biosynthetic process (GO:0009142)3.12383874
89rRNA processing (GO:0006364)3.08410395
90response to interferon-beta (GO:0035456)3.07630761
91ribosome biogenesis (GO:0042254)3.07160434
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03424521
93rRNA metabolic process (GO:0016072)3.01383606
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00191095
95signal peptide processing (GO:0006465)2.97582113
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.97305898
97quinone biosynthetic process (GO:1901663)2.96614691
98GPI anchor biosynthetic process (GO:0006506)2.96115916
99pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95624174
100pyrimidine nucleotide catabolic process (GO:0006244)2.94988886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85291454
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.52547586
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.31450038
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.03399940
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.49453276
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.47874130
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34511255
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19216751
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16935131
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.06156908
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05542615
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89050170
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84883057
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70663495
15VDR_23849224_ChIP-Seq_CD4+_Human2.64512191
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57105070
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.48710365
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45327875
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44146428
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43432171
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33257370
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30685989
23FOXP3_21729870_ChIP-Seq_TREG_Human2.28920224
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.08618067
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96503792
26DCP1A_22483619_ChIP-Seq_HELA_Human1.93895050
27XRN2_22483619_ChIP-Seq_HELA_Human1.89190427
28GABP_19822575_ChIP-Seq_HepG2_Human1.84824190
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79671495
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79494325
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78831429
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72158601
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72080306
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72065712
35TTF2_22483619_ChIP-Seq_HELA_Human1.67001212
36ELK1_19687146_ChIP-ChIP_HELA_Human1.60687550
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46365558
38MYC_18940864_ChIP-ChIP_HL60_Human1.42741789
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40796299
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40739489
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36675620
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33727194
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.33059737
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29850667
45CIITA_25753668_ChIP-Seq_RAJI_Human1.29448519
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29432533
47TP53_22573176_ChIP-Seq_HFKS_Human1.26149983
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24191998
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23668108
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22833229
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22087703
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21796454
53ZNF274_21170338_ChIP-Seq_K562_Hela1.21198488
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.20277444
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.16888717
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16862334
57TAF2_19829295_ChIP-Seq_ESCs_Human1.13856723
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13458519
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13123207
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10517495
61CTCF_20526341_ChIP-Seq_ESCs_Human1.08783627
62HTT_18923047_ChIP-ChIP_STHdh_Human1.08662267
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07240284
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05708410
65BCL6_27268052_Chip-Seq_Bcells_Human1.05426275
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05015289
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03261449
68NANOG_20526341_ChIP-Seq_ESCs_Human1.01568214
69KDM5A_27292631_Chip-Seq_BREAST_Human1.01491649
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01192914
71BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99695006
72NCOR_22424771_ChIP-Seq_293T_Human0.99327643
73ZNF263_19887448_ChIP-Seq_K562_Human0.98995647
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98612103
75IRF8_22096565_ChIP-ChIP_GC-B_Human0.98248076
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95692969
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95315059
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93948550
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93286077
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.93286077
81VDR_22108803_ChIP-Seq_LS180_Human0.92650213
82MYC_19829295_ChIP-Seq_ESCs_Human0.91682833
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91591182
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90917272
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90580477
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89523271
87SA1_27219007_Chip-Seq_Bcells_Human0.88382338
88STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88017362
89NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87924890
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87882152
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.87674840
92ERA_21632823_ChIP-Seq_H3396_Human0.86439754
93AR_20517297_ChIP-Seq_VCAP_Human0.86384100
94E2F1_20622854_ChIP-Seq_HELA_Human0.86136483
95ERG_20517297_ChIP-Seq_VCAP_Human0.84443204
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.83467922
97E2F7_22180533_ChIP-Seq_HELA_Human0.83029669
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82342752
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81544929
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80921398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.34643667
2MP0009379_abnormal_foot_pigmentation3.59708876
3MP0006292_abnormal_olfactory_placode3.45555079
4MP0002837_dystrophic_cardiac_calcinosis2.94364271
5MP0004147_increased_porphyrin_level2.87587238
6MP0005379_endocrine/exocrine_gland_phen2.87090682
7MP0005671_abnormal_response_to2.82456080
8MP0003786_premature_aging2.57913576
9MP0000372_irregular_coat_pigmentation2.51580752
10MP0003123_paternal_imprinting2.30453439
11MP0004145_abnormal_muscle_electrophysio2.19014809
12MP0001835_abnormal_antigen_presentation2.04134927
13MP0002166_altered_tumor_susceptibility1.97764919
14MP0002277_abnormal_respiratory_mucosa1.96073482
15MP0002736_abnormal_nociception_after1.84991833
16MP0005646_abnormal_pituitary_gland1.78306935
17MP0001188_hyperpigmentation1.75735150
18MP0001968_abnormal_touch/_nociception1.73878404
19MP0009333_abnormal_splenocyte_physiolog1.72876396
20MP0003878_abnormal_ear_physiology1.69978395
21MP0005377_hearing/vestibular/ear_phenot1.69978395
22MP0002160_abnormal_reproductive_system1.68726454
23MP0005389_reproductive_system_phenotype1.68656021
24MP0009785_altered_susceptibility_to1.68479595
25MP0001919_abnormal_reproductive_system1.66009937
26MP0003693_abnormal_embryo_hatching1.63508776
27MP0003646_muscle_fatigue1.60659418
28MP0008875_abnormal_xenobiotic_pharmacok1.55845860
29MP0009046_muscle_twitch1.52181557
30MP0003195_calcinosis1.51076666
31MP0004142_abnormal_muscle_tone1.41922088
32MP0002006_tumorigenesis1.41590278
33MP0008877_abnormal_DNA_methylation1.36197311
34MP0001905_abnormal_dopamine_level1.33961765
35MP0001986_abnormal_taste_sensitivity1.33527305
36MP0001542_abnormal_bone_strength1.32998464
37MP0008872_abnormal_physiological_respon1.31728957
38MP0005551_abnormal_eye_electrophysiolog1.29496050
39MP0002102_abnormal_ear_morphology1.29452747
40MP0006072_abnormal_retinal_apoptosis1.28560728
41MP0009745_abnormal_behavioral_response1.27891981
42MP0001853_heart_inflammation1.26890646
43MP0006276_abnormal_autonomic_nervous1.22015230
44MP0002938_white_spotting1.20911737
45MP0005645_abnormal_hypothalamus_physiol1.20369406
46MP0006036_abnormal_mitochondrial_physio1.19126562
47MP0000049_abnormal_middle_ear1.15883787
48MP0003866_abnormal_defecation1.15105678
49MP0005636_abnormal_mineral_homeostasis1.14563091
50MP0000631_abnormal_neuroendocrine_gland1.14525629
51MP0002095_abnormal_skin_pigmentation1.12161860
52MP0003763_abnormal_thymus_physiology1.11675117
53MP0005423_abnormal_somatic_nervous1.10616203
54MP0005084_abnormal_gallbladder_morpholo1.10342467
55MP0001661_extended_life_span1.08909276
56MP0002638_abnormal_pupillary_reflex1.08026789
57MP0005187_abnormal_penis_morphology1.07448447
58MP0002148_abnormal_hypersensitivity_rea1.07445467
59MP0003186_abnormal_redox_activity1.04979098
60MP0000685_abnormal_immune_system1.04918726
61MP0003787_abnormal_imprinting1.01933120
62MP0008995_early_reproductive_senescence0.97908802
63MP0008007_abnormal_cellular_replicative0.95409472
64MP0001800_abnormal_humoral_immune0.94242708
65MP0002234_abnormal_pharynx_morphology0.93266499
66MP0005410_abnormal_fertilization0.91821300
67MP0002876_abnormal_thyroid_physiology0.90766973
68MP0005584_abnormal_enzyme/coenzyme_acti0.87440711
69MP0006035_abnormal_mitochondrial_morpho0.86847045
70MP0008789_abnormal_olfactory_epithelium0.86786903
71MP0002272_abnormal_nervous_system0.86331841
72MP0001485_abnormal_pinna_reflex0.85472294
73MP0001765_abnormal_ion_homeostasis0.84609272
74MP0005025_abnormal_response_to0.84206139
75MP0002420_abnormal_adaptive_immunity0.82722344
76MP0003011_delayed_dark_adaptation0.81805382
77MP0000678_abnormal_parathyroid_gland0.81519652
78MP0005332_abnormal_amino_acid0.81127321
79MP0002751_abnormal_autonomic_nervous0.80784821
80MP0003137_abnormal_impulse_conducting0.80709278
81MP0004957_abnormal_blastocyst_morpholog0.80603677
82MP0002723_abnormal_immune_serum0.80421654
83MP0003567_abnormal_fetal_cardiomyocyte0.78242482
84MP0000639_abnormal_adrenal_gland0.77641327
85MP0002210_abnormal_sex_determination0.77591827
86MP0001819_abnormal_immune_cell0.76436123
87MP0002733_abnormal_thermal_nociception0.75143509
88MP0001881_abnormal_mammary_gland0.74207057
89MP0001790_abnormal_immune_system0.72363752
90MP0005387_immune_system_phenotype0.72363752
91MP0000604_amyloidosis0.71424537
92MP0003806_abnormal_nucleotide_metabolis0.69823395
93MP0004885_abnormal_endolymph0.69327766
94MP0001764_abnormal_homeostasis0.69135298
95MP0002933_joint_inflammation0.68943916
96MP0002064_seizures0.67534252
97MP0009643_abnormal_urine_homeostasis0.66499508
98MP0006082_CNS_inflammation0.66470757
99MP0003136_yellow_coat_color0.66378830
100MP0001119_abnormal_female_reproductive0.65960064

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.59663252
2Increased hepatocellular lipid droplets (HP:0006565)5.34691857
3Renal Fanconi syndrome (HP:0001994)5.02515218
4Mitochondrial inheritance (HP:0001427)4.89119114
5Lipid accumulation in hepatocytes (HP:0006561)4.76836568
6Acute necrotizing encephalopathy (HP:0006965)4.69669457
7Increased intramyocellular lipid droplets (HP:0012240)4.68742186
8Increased CSF lactate (HP:0002490)4.43433620
9Abnormal mitochondria in muscle tissue (HP:0008316)4.32684413
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.17255035
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.17255035
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.99992348
13Acute encephalopathy (HP:0006846)3.96451323
14Increased muscle lipid content (HP:0009058)3.88560550
15Progressive macrocephaly (HP:0004481)3.84298923
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.79385225
17Aplastic anemia (HP:0001915)3.78573705
18Exertional dyspnea (HP:0002875)3.53451058
19Hepatic necrosis (HP:0002605)3.43425325
20Hepatocellular necrosis (HP:0001404)3.36789270
21Lactic acidosis (HP:0003128)3.35925812
22Increased serum lactate (HP:0002151)3.26807746
23Cerebral edema (HP:0002181)3.24916188
24Generalized aminoaciduria (HP:0002909)3.23923975
25Abnormality of renal resorption (HP:0011038)3.12692377
26Congenital stationary night blindness (HP:0007642)3.05523450
27IgG deficiency (HP:0004315)3.05264620
28Elevated erythrocyte sedimentation rate (HP:0003565)3.03865497
29Respiratory difficulties (HP:0002880)3.03361781
30Hyperphosphaturia (HP:0003109)3.00052667
31Abnormality of urine glucose concentration (HP:0011016)2.89212322
32Glycosuria (HP:0003076)2.89212322
33Macrocytic anemia (HP:0001972)2.80341036
34Exercise intolerance (HP:0003546)2.78697615
35Abnormal number of erythroid precursors (HP:0012131)2.73722632
36Abnormality of cells of the erythroid lineage (HP:0012130)2.73239516
37Stomatitis (HP:0010280)2.56062447
38Optic disc pallor (HP:0000543)2.54796974
39Respiratory failure (HP:0002878)2.54272538
40Reticulocytopenia (HP:0001896)2.49767423
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46236271
42Abnormality of alanine metabolism (HP:0010916)2.46236271
43Hyperalaninemia (HP:0003348)2.46236271
44Severe combined immunodeficiency (HP:0004430)2.45391073
45Progressive microcephaly (HP:0000253)2.42852694
46Pancytopenia (HP:0001876)2.38277152
47Oral leukoplakia (HP:0002745)2.35241960
48Type II lissencephaly (HP:0007260)2.35210852
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31905517
50Metaphyseal dysplasia (HP:0100255)2.30040028
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28975555
52Abnormal urine phosphate concentration (HP:0012599)2.27106349
53T lymphocytopenia (HP:0005403)2.26059596
54Congenital, generalized hypertrichosis (HP:0004540)2.25425015
55Increased IgM level (HP:0003496)2.22004176
56Lethargy (HP:0001254)2.19479257
57Cerebral hypomyelination (HP:0006808)2.15659368
58Abnormality of T cell number (HP:0011839)2.12804253
59Abnormal rod and cone electroretinograms (HP:0008323)2.11997173
60Renal cortical cysts (HP:0000803)2.11215419
61Pancreatic cysts (HP:0001737)2.11129995
62Abnormality of midbrain morphology (HP:0002418)2.07033655
63Molar tooth sign on MRI (HP:0002419)2.07033655
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00790317
65Abnormality of T cells (HP:0002843)1.98469279
66Pancreatic fibrosis (HP:0100732)1.94467750
67Leukodystrophy (HP:0002415)1.93144286
68Abnormality of magnesium homeostasis (HP:0004921)1.92697951
69Abnormality of placental membranes (HP:0011409)1.92445512
70Amniotic constriction ring (HP:0009775)1.92445512
71Cellular immunodeficiency (HP:0005374)1.92411924
72Testicular atrophy (HP:0000029)1.90565083
73True hermaphroditism (HP:0010459)1.85112247
74Dicarboxylic aciduria (HP:0003215)1.84569888
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84569888
76Abnormality of the renal cortex (HP:0011035)1.84546536
77Dynein arm defect of respiratory motile cilia (HP:0012255)1.84423084
78Absent/shortened dynein arms (HP:0200106)1.84423084
79Renal tubular dysfunction (HP:0000124)1.83081677
80Myokymia (HP:0002411)1.82949148
81Pallor (HP:0000980)1.80625533
82Constricted visual fields (HP:0001133)1.79926946
83Symphalangism affecting the phalanges of the hand (HP:0009773)1.79085975
84Concave nail (HP:0001598)1.72342621
85Hypoproteinemia (HP:0003075)1.70975216
86Muscle fiber atrophy (HP:0100295)1.68787413
87Type 2 muscle fiber atrophy (HP:0003554)1.65975256
88Rib fusion (HP:0000902)1.65955934
89Combined immunodeficiency (HP:0005387)1.65439250
90Opisthotonus (HP:0002179)1.64857528
91Retinal dysplasia (HP:0007973)1.64036203
92Tetany (HP:0001281)1.62696400
93Nausea (HP:0002018)1.62694717
94Sparse eyelashes (HP:0000653)1.60988489
95Neuroendocrine neoplasm (HP:0100634)1.58653778
96Emotional lability (HP:0000712)1.58466187
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.55203635
98CNS demyelination (HP:0007305)1.54610985
99Thyroiditis (HP:0100646)1.53539291
100Absent thumb (HP:0009777)1.53171953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.73070229
2KDR3.68747282
3MAP4K23.44624549
4BCKDK3.11097941
5NUAK13.01210507
6TXK2.93553325
7NME22.92956970
8VRK22.57160415
9WNK42.40981259
10STK162.29720842
11ZAK2.26537061
12MAP3K122.02984449
13LIMK12.00279392
14TLK12.00103504
15BUB11.97387028
16TESK11.86678522
17NME11.85542586
18PDK21.78798591
19GRK11.76317787
20MAP3K111.64020932
21ADRBK21.60396182
22MAP4K11.53456866
23EIF2AK11.45252085
24DYRK21.41960774
25ITK1.39449784
26PIK3CA1.37639204
27TIE11.36484327
28VRK11.25602633
29DAPK21.13915240
30NEK11.13694157
31BMPR1B1.10085289
32PLK41.09995543
33DAPK11.07878161
34PIM21.06468787
35STK391.06282792
36CSNK1G31.05725411
37MATK0.99715932
38NTRK30.98465924
39FES0.94695855
40TEC0.94416848
41RPS6KA50.93028332
42TRIM280.92267954
43MAPKAPK30.91712731
44PRKCQ0.86319350
45AURKA0.86087982
46TAOK30.85160029
47INSRR0.84324416
48MYLK0.78666129
49SYK0.74475218
50CSNK1A1L0.72811702
51CDC70.72386241
52PINK10.69757668
53CSNK1G10.69345040
54CSNK2A20.69236580
55CSNK1G20.68184358
56ILK0.67191118
57DAPK30.66416210
58CSNK2A10.65234954
59CAMKK20.62864501
60CSK0.62697142
61MAPK110.62140559
62GRK60.59829099
63AURKB0.58774145
64WNK30.58162740
65LCK0.57546347
66ADRBK10.56362225
67LRRK20.53740776
68FRK0.53695657
69PIM10.53099371
70PHKG20.52860452
71PHKG10.52860452
72NTRK10.52339204
73PASK0.52157832
74GRK70.51727128
75EIF2AK30.51443084
76GRK50.50789212
77KIT0.50530917
78LYN0.49778855
79ABL20.48379889
80ATR0.45832863
81MUSK0.45367050
82RIPK40.45297657
83ZAP700.44341007
84OBSCN0.43586304
85OXSR10.42979091
86PRKCG0.42781335
87AKT20.42486873
88MAPK130.41829651
89PRKACA0.41031274
90CSNK1A10.41017863
91IKBKB0.40706191
92ERBB20.40205572
93PRKCA0.39410006
94MAPKAPK50.38693839
95RPS6KA40.38195524
96INSR0.38103226
97CDK80.37592272
98SRPK10.36946735
99BCR0.35717906
100PLK20.32983602

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.00900742
2Ribosome_Homo sapiens_hsa030104.88011448
3Proteasome_Homo sapiens_hsa030504.71329623
4Parkinsons disease_Homo sapiens_hsa050124.33538613
5Huntingtons disease_Homo sapiens_hsa050162.93221445
6Alzheimers disease_Homo sapiens_hsa050102.88965420
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.54957451
8Primary immunodeficiency_Homo sapiens_hsa053402.50482285
9RNA polymerase_Homo sapiens_hsa030202.46969480
10Protein export_Homo sapiens_hsa030602.42366408
11Cardiac muscle contraction_Homo sapiens_hsa042602.34426926
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25121851
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06603271
14DNA replication_Homo sapiens_hsa030301.77009164
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63554723
16Pyrimidine metabolism_Homo sapiens_hsa002401.62797673
17Homologous recombination_Homo sapiens_hsa034401.52361020
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49676163
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41126101
20Antigen processing and presentation_Homo sapiens_hsa046121.40131175
21Sulfur metabolism_Homo sapiens_hsa009201.39305596
22Spliceosome_Homo sapiens_hsa030401.38212775
23Autoimmune thyroid disease_Homo sapiens_hsa053201.30146463
24Allograft rejection_Homo sapiens_hsa053301.29458488
25One carbon pool by folate_Homo sapiens_hsa006701.29377875
26Phototransduction_Homo sapiens_hsa047441.19724094
27Graft-versus-host disease_Homo sapiens_hsa053321.17096529
28Collecting duct acid secretion_Homo sapiens_hsa049661.17030530
29Nitrogen metabolism_Homo sapiens_hsa009101.16700935
30Mismatch repair_Homo sapiens_hsa034301.14640346
31Purine metabolism_Homo sapiens_hsa002301.08116497
32Basal transcription factors_Homo sapiens_hsa030221.03825208
33Sulfur relay system_Homo sapiens_hsa041221.03075863
34Asthma_Homo sapiens_hsa053101.02696817
35Type I diabetes mellitus_Homo sapiens_hsa049401.01538700
36RNA transport_Homo sapiens_hsa030131.00889992
37Folate biosynthesis_Homo sapiens_hsa007900.98895860
38Nucleotide excision repair_Homo sapiens_hsa034200.98341182
39Fatty acid elongation_Homo sapiens_hsa000620.96051472
40Fanconi anemia pathway_Homo sapiens_hsa034600.95440256
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94449945
42Caffeine metabolism_Homo sapiens_hsa002320.93367419
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93254219
44Vitamin B6 metabolism_Homo sapiens_hsa007500.90176569
45Rheumatoid arthritis_Homo sapiens_hsa053230.88842635
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83767428
47RNA degradation_Homo sapiens_hsa030180.82199343
48Hematopoietic cell lineage_Homo sapiens_hsa046400.77890356
49Butanoate metabolism_Homo sapiens_hsa006500.76530768
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.76170310
51Metabolic pathways_Homo sapiens_hsa011000.75063494
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74191784
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.73877796
54Linoleic acid metabolism_Homo sapiens_hsa005910.73302880
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72906212
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71935397
57Base excision repair_Homo sapiens_hsa034100.68607989
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68487078
59Tryptophan metabolism_Homo sapiens_hsa003800.65915864
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54316965
61Systemic lupus erythematosus_Homo sapiens_hsa053220.54075913
62Chemical carcinogenesis_Homo sapiens_hsa052040.53650688
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.53085586
64Peroxisome_Homo sapiens_hsa041460.50612507
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50459286
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50063163
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48073718
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47016366
69Pyruvate metabolism_Homo sapiens_hsa006200.46586807
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45952475
71Propanoate metabolism_Homo sapiens_hsa006400.43395139
72T cell receptor signaling pathway_Homo sapiens_hsa046600.41356595
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.38665105
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38360452
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37582121
76Steroid biosynthesis_Homo sapiens_hsa001000.37532339
77Glutathione metabolism_Homo sapiens_hsa004800.34573273
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34429290
79Synaptic vesicle cycle_Homo sapiens_hsa047210.33987007
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32834980
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28856083
82Olfactory transduction_Homo sapiens_hsa047400.27650534
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27485074
84Retinol metabolism_Homo sapiens_hsa008300.24708225
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24046910
86Fatty acid degradation_Homo sapiens_hsa000710.22924681
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.22887157
88Fat digestion and absorption_Homo sapiens_hsa049750.22855789
89Tyrosine metabolism_Homo sapiens_hsa003500.19883366
90beta-Alanine metabolism_Homo sapiens_hsa004100.18990073
91Morphine addiction_Homo sapiens_hsa050320.18843722
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18465787
93Nicotine addiction_Homo sapiens_hsa050330.18407464
94Regulation of autophagy_Homo sapiens_hsa041400.17760700
95Arachidonic acid metabolism_Homo sapiens_hsa005900.17095456
96Selenocompound metabolism_Homo sapiens_hsa004500.16988970
97Measles_Homo sapiens_hsa051620.16507270
98Mineral absorption_Homo sapiens_hsa049780.16373211
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.15938540
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15261414

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »