ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.73208219
2	monoubiquitinated protein deubiquitination (GO:0035520)	6.58321097
3	behavioral response to nicotine (GO:0035095)	6.56453179
4	protein complex biogenesis (GO:0070271)	5.97287523
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.41299777
6	NADH dehydrogenase complex assembly (GO:0010257)	5.41299777
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.41299777
8	mitochondrial respiratory chain complex assembly (GO:0033108)	5.23152105
9	water-soluble vitamin biosynthetic process (GO:0042364)	5.13028417
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.99548836
11	ATP synthesis coupled proton transport (GO:0015986)	4.74770537
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.74770537
13	serotonin metabolic process (GO:0042428)	4.44481207
14	primary amino compound metabolic process (GO:1901160)	4.36334975
15	chaperone-mediated protein transport (GO:0072321)	4.31598797
16	protein neddylation (GO:0045116)	4.28906816
17	negative regulation of membrane potential (GO:0045837)	4.20541401
18	viral transcription (GO:0019083)	4.13157027
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.10538091
20	sequestering of actin monomers (GO:0042989)	4.08482321
21	indolalkylamine metabolic process (GO:0006586)	4.07644589
22	neuron fate determination (GO:0048664)	3.99358018
23	regulation of male gonad development (GO:2000018)	3.98539134
24	translational termination (GO:0006415)	3.98249357
25	DNA deamination (GO:0045006)	3.89502706
26	inner mitochondrial membrane organization (GO:0007007)	3.87740716
27	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.80447555
28	glyoxylate metabolic process (GO:0046487)	3.79949018
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.78716669
30	electron transport chain (GO:0022900)	3.78278287
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.76137768
32	respiratory electron transport chain (GO:0022904)	3.75784276
33	intracellular protein transmembrane import (GO:0044743)	3.71826052
34	base-excision repair, AP site formation (GO:0006285)	3.70657461
35	cotranslational protein targeting to membrane (GO:0006613)	3.69227155
36	protein targeting to ER (GO:0045047)	3.69204735
37	response to auditory stimulus (GO:0010996)	3.61188151
38	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.61013618
39	regulation of cardioblast proliferation (GO:0003264)	3.61013618
40	protein localization to endoplasmic reticulum (GO:0070972)	3.60665150
41	presynaptic membrane assembly (GO:0097105)	3.55319824
42	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.53708303
43	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.51280558
44	replication fork processing (GO:0031297)	3.46798147
45	regulation of mitochondrial translation (GO:0070129)	3.44239857
46	adenosine metabolic process (GO:0046085)	3.35946163
47	indole-containing compound metabolic process (GO:0042430)	3.25885768
48	transmission of nerve impulse (GO:0019226)	3.24588444
49	protein localization to microtubule (GO:0035372)	3.24071789
50	midbrain development (GO:0030901)	3.23361138
51	GTP biosynthetic process (GO:0006183)	3.22455627
52	dopaminergic neuron differentiation (GO:0071542)	3.21155274
53	resolution of meiotic recombination intermediates (GO:0000712)	3.19953110
54	translational elongation (GO:0006414)	3.19497567
55	proteasome assembly (GO:0043248)	3.18567629
56	cellular biogenic amine biosynthetic process (GO:0042401)	3.13319556
57	auditory behavior (GO:0031223)	3.10696319
58	ribosomal small subunit assembly (GO:0000028)	3.04910706
59	regulation of timing of cell differentiation (GO:0048505)	3.03951690
60	pseudouridine synthesis (GO:0001522)	3.02139258
61	cellular protein complex disassembly (GO:0043624)	3.01769611
62	organelle disassembly (GO:1903008)	2.98430659
63	regulation of meiosis I (GO:0060631)	2.97847071
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.95599309
65	intracellular protein transmembrane transport (GO:0065002)	2.94264189
66	amine biosynthetic process (GO:0009309)	2.92943067
67	positive regulation of fatty acid oxidation (GO:0046321)	2.92595850
68	viral life cycle (GO:0019058)	2.89629679
69	positive regulation by host of viral transcription (GO:0043923)	2.86931898
70	otic vesicle formation (GO:0030916)	2.83926651
71	cytochrome complex assembly (GO:0017004)	2.83581020
72	ribosomal small subunit biogenesis (GO:0042274)	2.82887324
73	positive regulation of meiosis (GO:0045836)	2.82827094
74	presynaptic membrane organization (GO:0097090)	2.82527655
75	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.82226533
76	regulation of fatty acid beta-oxidation (GO:0031998)	2.80131335
77	translational initiation (GO:0006413)	2.78524867
78	maternal behavior (GO:0042711)	2.78524130
79	epithelial cilium movement (GO:0003351)	2.77330811
80	limb bud formation (GO:0060174)	2.75898579
81	dopamine biosynthetic process (GO:0042416)	2.75475152
82	ribosomal large subunit biogenesis (GO:0042273)	2.74669317
83	rRNA modification (GO:0000154)	2.71801038
84	regulation of development, heterochronic (GO:0040034)	2.71689355
85	positive regulation of meiotic cell cycle (GO:0051446)	2.70214415
86	primitive streak formation (GO:0090009)	2.70026416
87	aldehyde catabolic process (GO:0046185)	2.68654164
88	neurofilament cytoskeleton organization (GO:0060052)	2.67912575
89	nephron epithelium morphogenesis (GO:0072088)	2.67426431
90	nephron tubule morphogenesis (GO:0072078)	2.67426431
91	translation (GO:0006412)	2.64750123
92	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.63481250
93	cytoplasmic mRNA processing body assembly (GO:0033962)	2.62210025
94	hydrogen ion transmembrane transport (GO:1902600)	2.62106164
95	positive regulation of astrocyte differentiation (GO:0048711)	2.61386974
96	negative regulation of glycogen biosynthetic process (GO:0045719)	2.61159352
97	UTP biosynthetic process (GO:0006228)	2.60948856
98	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.59826249
99	positive regulation of gastrulation (GO:2000543)	2.59738640
100	proton transport (GO:0015992)	2.58029420

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.95101314
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.57317825
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.77938260
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.47533796
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84552615
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84416612
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.80571190
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.59517977
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33528957
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31158491
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.29747287
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.28398285
13	FUS_26573619_Chip-Seq_HEK293_Human	2.20349250
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.18694821
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14046929
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13431174
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10204019
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.07174514
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05722057
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.04670631
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.01093658
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00027794
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.99636881
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97357679
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.79922060
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.79382437
27	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.77668008
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.74358855
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74056967
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.70765579
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69953364
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68404522
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65886958
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62927754
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60980213
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.57418518
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.55207542
38	HTT_18923047_ChIP-ChIP_STHdh_Human	1.51186531
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.47507636
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.47314267
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.40534335
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.39449176
43	P300_19829295_ChIP-Seq_ESCs_Human	1.39317437
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37357586
45	VDR_22108803_ChIP-Seq_LS180_Human	1.32723616
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32465988
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31071378
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30014184
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29928609
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29458433
51	ZNF274_21170338_ChIP-Seq_K562_Hela	1.28287007
52	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.28247108
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.26116680
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.23260115
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.22554238
56	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.21532150
57	EWS_26573619_Chip-Seq_HEK293_Human	1.16017178
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15784679
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15604744
60	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14983710
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14493621
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13028791
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12829278
64	NCOR_22424771_ChIP-Seq_293T_Human	1.12816511
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09666022
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09329744
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09048490
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08290232
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06648769
70	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06318001
71	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04164573
72	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03230655
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03230655
74	JUN_21703547_ChIP-Seq_K562_Human	1.01382219
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98828243
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97343841
77	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.95236425
78	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.95216933
79	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95194324
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94583448
81	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94447662
82	GABP_19822575_ChIP-Seq_HepG2_Human	0.90316850
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89530069
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88271578
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87565504
86	SOX2_21211035_ChIP-Seq_LN229_Human	0.86426333
87	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.86178856
88	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.86072459
89	ERA_21632823_ChIP-Seq_H3396_Human	0.86071541
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85850774
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84946883
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84946883
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84683779
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84683779
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.84636372
96	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.84595375
97	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.84161747
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.83208084
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.82749069
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.82737305

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.80420013
2	MP0002837_dystrophic_cardiac_calcinosis	3.96120951
3	MP0003122_maternal_imprinting	3.84682322
4	MP0000566_synostosis	3.75372088
5	MP0003011_delayed_dark_adaptation	3.52260808
6	MP0005084_abnormal_gallbladder_morpholo	3.17668255
7	MP0001529_abnormal_vocalization	3.12998063
8	MP0009379_abnormal_foot_pigmentation	2.62809360
9	MP0004145_abnormal_muscle_electrophysio	2.48515346
10	MP0002938_white_spotting	2.41906361
11	MP0002928_abnormal_bile_duct	2.30395334
12	MP0001905_abnormal_dopamine_level	2.26582687
13	MP0010030_abnormal_orbit_morphology	2.26371536
14	MP0003890_abnormal_embryonic-extraembry	2.14954691
15	MP0002277_abnormal_respiratory_mucosa	2.14202107
16	MP0002102_abnormal_ear_morphology	2.10679244
17	MP0000569_abnormal_digit_pigmentation	2.03096042
18	MP0002736_abnormal_nociception_after	2.00214549
19	MP0004133_heterotaxia	1.91582272
20	MP0003121_genomic_imprinting	1.82215752
21	MP0002735_abnormal_chemical_nociception	1.80139617
22	MP0001986_abnormal_taste_sensitivity	1.79251640
23	MP0006292_abnormal_olfactory_placode	1.78692120
24	MP0000537_abnormal_urethra_morphology	1.78508930
25	MP0001984_abnormal_olfaction	1.75122598
26	MP0004142_abnormal_muscle_tone	1.62553328
27	MP0008775_abnormal_heart_ventricle	1.60810093
28	MP0005408_hypopigmentation	1.57210021
29	MP0000778_abnormal_nervous_system	1.52512024
30	MP0002653_abnormal_ependyma_morphology	1.52085628
31	MP0008789_abnormal_olfactory_epithelium	1.52048818
32	MP0001968_abnormal_touch/_nociception	1.46101956
33	MP0004742_abnormal_vestibular_system	1.44123574
34	MP0008872_abnormal_physiological_respon	1.43089059
35	MP0004924_abnormal_behavior	1.38212787
36	MP0005386_behavior/neurological_phenoty	1.38212787
37	MP0000049_abnormal_middle_ear	1.37543695
38	MP0009250_abnormal_appendicular_skeleto	1.32782234
39	MP0000026_abnormal_inner_ear	1.30084240
40	MP0001853_heart_inflammation	1.29631565
41	MP0001486_abnormal_startle_reflex	1.27650890
42	MP0000372_irregular_coat_pigmentation	1.23701451
43	MP0002282_abnormal_trachea_morphology	1.19569415
44	MP0001286_abnormal_eye_development	1.19486325
45	MP0003937_abnormal_limbs/digits/tail_de	1.19336304
46	MP0004147_increased_porphyrin_level	1.17364271
47	MP0003938_abnormal_ear_development	1.14774758
48	MP0001293_anophthalmia	1.14668430
49	MP0002067_abnormal_sensory_capabilities	1.11208458
50	MP0002638_abnormal_pupillary_reflex	1.10691580
51	MP0002272_abnormal_nervous_system	1.10309904
52	MP0002572_abnormal_emotion/affect_behav	1.08839624
53	MP0002932_abnormal_joint_morphology	1.07042772
54	MP0002233_abnormal_nose_morphology	1.05004180
55	MP0003755_abnormal_palate_morphology	1.04653160
56	MP0001324_abnormal_eye_pigmentation	1.03626481
57	MP0009745_abnormal_behavioral_response	1.02942184
58	MP0008875_abnormal_xenobiotic_pharmacok	1.02226097
59	MP0002557_abnormal_social/conspecific_i	0.98972633
60	MP0001485_abnormal_pinna_reflex	0.96770838
61	MP0001440_abnormal_grooming_behavior	0.95575850
62	MP0000631_abnormal_neuroendocrine_gland	0.95223388
63	MP0009046_muscle_twitch	0.94938612
64	MP0005083_abnormal_biliary_tract	0.91520876
65	MP0002095_abnormal_skin_pigmentation	0.91137292
66	MP0002752_abnormal_somatic_nervous	0.90212295
67	MP0000749_muscle_degeneration	0.88975928
68	MP0002064_seizures	0.88892224
69	MP0000579_abnormal_nail_morphology	0.88766827
70	MP0005551_abnormal_eye_electrophysiolog	0.87539028
71	MP0002697_abnormal_eye_size	0.86617357
72	MP0001963_abnormal_hearing_physiology	0.85239705
73	MP0005670_abnormal_white_adipose	0.83547570
74	MP0000955_abnormal_spinal_cord	0.80017457
75	MP0002234_abnormal_pharynx_morphology	0.78757414
76	MP0005075_abnormal_melanosome_morpholog	0.77535140
77	MP0005389_reproductive_system_phenotype	0.77139249
78	MP0001270_distended_abdomen	0.76669935
79	MP0006072_abnormal_retinal_apoptosis	0.75981847
80	MP0005253_abnormal_eye_physiology	0.74880116
81	MP0002876_abnormal_thyroid_physiology	0.73748634
82	MP0003880_abnormal_central_pattern	0.72734694
83	MP0001188_hyperpigmentation	0.72131007
84	MP0001727_abnormal_embryo_implantation	0.71960538
85	MP0005195_abnormal_posterior_eye	0.71144685
86	MP0000538_abnormal_urinary_bladder	0.70818015
87	MP0005394_taste/olfaction_phenotype	0.66945046
88	MP0005499_abnormal_olfactory_system	0.66945046
89	MP0000015_abnormal_ear_pigmentation	0.66417228
90	MP0002160_abnormal_reproductive_system	0.66103152
91	MP0002063_abnormal_learning/memory/cond	0.65818611
92	MP0002138_abnormal_hepatobiliary_system	0.65409181
93	MP0005332_abnormal_amino_acid	0.63849459
94	MP0005645_abnormal_hypothalamus_physiol	0.62818801
95	MP0002184_abnormal_innervation	0.62599770
96	MP0003567_abnormal_fetal_cardiomyocyte	0.62509386
97	MP0005423_abnormal_somatic_nervous	0.62082648
98	MP0001346_abnormal_lacrimal_gland	0.62026204
99	MP0003252_abnormal_bile_duct	0.60553060
100	MP0001919_abnormal_reproductive_system	0.58729904

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cutaneous melanoma (HP:0012056)	7.05201068
2	Type II lissencephaly (HP:0007260)	5.19911577
3	Hyperglycinemia (HP:0002154)	4.81097858
4	Cerebellar dysplasia (HP:0007033)	4.54972319
5	Calf muscle hypertrophy (HP:0008981)	4.31743095
6	Acute necrotizing encephalopathy (HP:0006965)	4.09432889
7	Acute encephalopathy (HP:0006846)	4.04483295
8	Meningioma (HP:0002858)	3.87698094
9	Muscle hypertrophy of the lower extremities (HP:0008968)	3.81174038
10	Progressive macrocephaly (HP:0004481)	3.75508279
11	Methylmalonic acidemia (HP:0002912)	3.64584961
12	Mitochondrial inheritance (HP:0001427)	3.63855791
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.58501976
14	Congenital, generalized hypertrichosis (HP:0004540)	3.39841971
15	Methylmalonic aciduria (HP:0012120)	3.30315306
16	Abnormal pupillary function (HP:0007686)	3.21496211
17	Hypothermia (HP:0002045)	3.06305777
18	Increased hepatocellular lipid droplets (HP:0006565)	3.05757727
19	3-Methylglutaconic aciduria (HP:0003535)	3.01767497
20	Increased CSF lactate (HP:0002490)	2.92325346
21	Fibular aplasia (HP:0002990)	2.85747783
22	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.77986640
23	Hepatocellular necrosis (HP:0001404)	2.77210490
24	Lipid accumulation in hepatocytes (HP:0006561)	2.74591406
25	Hypoplasia of the pons (HP:0012110)	2.70434734
26	Concave nail (HP:0001598)	2.66879994
27	Abnormality of the labia minora (HP:0012880)	2.65714257
28	Delayed gross motor development (HP:0002194)	2.62957097
29	Increased intramyocellular lipid droplets (HP:0012240)	2.59584042
30	Lissencephaly (HP:0001339)	2.57507282
31	Limb hypertonia (HP:0002509)	2.57344606
32	Limb dystonia (HP:0002451)	2.57086643
33	Abnormality of the pons (HP:0007361)	2.55867559
34	Synostosis involving the elbow (HP:0003938)	2.52672972
35	Humeroradial synostosis (HP:0003041)	2.52672972
36	Cerebral edema (HP:0002181)	2.51249575
37	Shoulder girdle muscle weakness (HP:0003547)	2.45214404
38	Hepatic necrosis (HP:0002605)	2.44601722
39	Renal Fanconi syndrome (HP:0001994)	2.38409521
40	Achilles tendon contracture (HP:0001771)	2.37442629
41	Congenital stationary night blindness (HP:0007642)	2.34342324
42	Myoglobinuria (HP:0002913)	2.34267998
43	Limb-girdle muscle atrophy (HP:0003797)	2.31287730
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29629690
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.29142038
46	Dicarboxylic aciduria (HP:0003215)	2.29142038
47	Abnormal number of erythroid precursors (HP:0012131)	2.27704324
48	Pelvic girdle muscle weakness (HP:0003749)	2.25668065
49	Reticulocytopenia (HP:0001896)	2.23672570
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20500477
51	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.18154218
52	Abnormality of glycine metabolism (HP:0010895)	2.15028454
53	Abnormality of serine family amino acid metabolism (HP:0010894)	2.15028454
54	Retinal dysplasia (HP:0007973)	2.14152175
55	Macrocytic anemia (HP:0001972)	2.14147591
56	Aqueductal stenosis (HP:0002410)	2.13574580
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10918077
58	Abnormality of the Achilles tendon (HP:0005109)	2.08776692
59	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.07385139
60	Lethargy (HP:0001254)	2.07340991
61	Polyphagia (HP:0002591)	2.06409966
62	Increased muscle lipid content (HP:0009058)	2.06379671
63	Pachygyria (HP:0001302)	2.06288788
64	Optic disc pallor (HP:0000543)	2.05674656
65	Abnormality of the musculature of the pelvis (HP:0001469)	2.02129311
66	Abnormality of the hip-girdle musculature (HP:0001445)	2.02129311
67	Pancytopenia (HP:0001876)	2.01182582
68	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.98196328
69	Exertional dyspnea (HP:0002875)	1.93529966
70	Amyotrophic lateral sclerosis (HP:0007354)	1.93203014
71	Adactyly (HP:0009776)	1.92546163
72	Partial duplication of the phalanx of hand (HP:0009999)	1.92199309
73	Testicular atrophy (HP:0000029)	1.91797665
74	Abnormality of vitamin B metabolism (HP:0004340)	1.90347826
75	Aplasia of the phalanges of the hand (HP:0009802)	1.88799028
76	Aplasia involving bones of the extremities (HP:0009825)	1.88799028
77	Aplasia involving bones of the upper limbs (HP:0009823)	1.88799028
78	Abnormality of the middle phalanges of the toes (HP:0010183)	1.86750196
79	Oral leukoplakia (HP:0002745)	1.86510705
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86299036
81	Respiratory distress (HP:0002098)	1.84845965
82	Frequent falls (HP:0002359)	1.83156727
83	Abnormality of the corticospinal tract (HP:0002492)	1.82031988
84	Abnormality of serum amino acid levels (HP:0003112)	1.81704192
85	Focal motor seizures (HP:0011153)	1.80927741
86	Leukodystrophy (HP:0002415)	1.80673777
87	Absent thumb (HP:0009777)	1.79406157
88	Mesomelia (HP:0003027)	1.78601212
89	Exercise intolerance (HP:0003546)	1.78429133
90	Abnormality of the calf musculature (HP:0001430)	1.78350768
91	Short femoral neck (HP:0100864)	1.78186017
92	Emotional lability (HP:0000712)	1.76046978
93	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.75730241
94	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.75730241
95	Meningocele (HP:0002435)	1.74718794
96	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.73498559
97	True hermaphroditism (HP:0010459)	1.72963724
98	Lactic acidosis (HP:0003128)	1.72132105
99	Abnormality of the vitreous humor (HP:0004327)	1.69361482
100	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.67743094

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.93795571
2	MAPK15	6.42277147
3	MAP3K10	4.03727424
4	VRK1	2.91722969
5	FRK	2.89746009
6	TSSK6	2.84161559
7	FGFR2	2.41806628
8	BCKDK	2.22091676
9	TIE1	2.19185607
10	MARK1	2.16262432
11	DYRK2	1.88803923
12	MAP3K12	1.73076989
13	ADRBK2	1.68124073
14	TLK1	1.61471546
15	TAF1	1.60306334
16	GRK1	1.39298394
17	MINK1	1.34060948
18	PLK3	1.32025540
19	NUAK1	1.32025397
20	EPHB2	1.31984596
21	SGK223	1.25416647
22	SGK494	1.25416647
23	SGK2	1.21654419
24	TXK	1.17597634
25	MAP2K7	1.16841681
26	CAMK1G	1.14421949
27	MAP3K11	1.07002846
28	WEE1	0.97595443
29	MAPK13	0.96481860
30	STK16	0.96241476
31	PRKCG	0.94687284
32	ZAK	0.94147162
33	CDK3	0.93831026
34	ERBB3	0.89803760
35	CDC7	0.89518604
36	MKNK2	0.89439952
37	EIF2AK1	0.86896591
38	CSNK1G1	0.86384952
39	NEK1	0.86237122
40	MAP3K13	0.85451731
41	NME1	0.84937200
42	KDR	0.83855170
43	LIMK1	0.82477649
44	PLK4	0.79744719
45	EIF2AK3	0.78393401
46	NTRK2	0.76290819
47	PKN1	0.75528935
48	CSNK1G2	0.75238660
49	AURKA	0.74225521
50	CSNK1G3	0.73321743
51	TGFBR1	0.72929522
52	ADRBK1	0.72735288
53	ROCK1	0.67914570
54	BUB1	0.67306094
55	CSNK1A1L	0.67220391
56	BMPR1B	0.66810228
57	OBSCN	0.65621968
58	RPS6KA2	0.64545158
59	ILK	0.64267142
60	RPS6KA6	0.62903689
61	MAP3K4	0.62362669
62	PINK1	0.60115840
63	PRKCH	0.59147202
64	INSRR	0.58404299
65	TAOK3	0.58075414
66	PHKG2	0.57460841
67	PHKG1	0.57460841
68	PASK	0.55980623
69	SGK1	0.54701615
70	RPS6KC1	0.54017593
71	RPS6KL1	0.54017593
72	MKNK1	0.53883501
73	WNK3	0.50648838
74	MAP4K2	0.47838274
75	PRKCZ	0.47557886
76	IKBKB	0.46009800
77	DYRK3	0.44612121
78	DAPK2	0.42563775
79	ATR	0.42417376
80	PIM2	0.40736925
81	GSK3A	0.39673112
82	ABL2	0.38544030
83	PLK2	0.38537809
84	CSNK1A1	0.38455444
85	SRPK1	0.37949687
86	CDK8	0.37369213
87	CSNK2A2	0.37135001
88	PRKG1	0.36801276
89	LRRK2	0.36678734
90	ROCK2	0.35964514
91	DAPK3	0.34701617
92	VRK2	0.34548342
93	NEK2	0.31916523
94	PRKCE	0.31490019
95	CSNK2A1	0.31107163
96	CHUK	0.31051540
97	DMPK	0.30867553
98	FGFR3	0.30361639
99	PRKACA	0.29867704
100	ARAF	0.29506334

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.60710527
2	Ribosome_Homo sapiens_hsa03010	4.32762846
3	Parkinsons disease_Homo sapiens_hsa05012	3.96688025
4	Protein export_Homo sapiens_hsa03060	3.25303673
5	Proteasome_Homo sapiens_hsa03050	3.21565141
6	Sulfur metabolism_Homo sapiens_hsa00920	3.08986142
7	Alzheimers disease_Homo sapiens_hsa05010	2.79527561
8	Huntingtons disease_Homo sapiens_hsa05016	2.62329771
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.57922737
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30467407
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.25346756
12	RNA polymerase_Homo sapiens_hsa03020	1.98712534
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95604884
14	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.75424297
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70167885
16	RNA degradation_Homo sapiens_hsa03018	1.69966315
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.66409906
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63077030
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59627182
20	Peroxisome_Homo sapiens_hsa04146	1.47745501
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44341576
22	Basal transcription factors_Homo sapiens_hsa03022	1.41978858
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.41812237
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.31911689
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.28188773
26	Phototransduction_Homo sapiens_hsa04744	1.28083009
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.23203855
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.15362423
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.12668168
30	Retinol metabolism_Homo sapiens_hsa00830	1.11375354
31	Spliceosome_Homo sapiens_hsa03040	0.93591270
32	Purine metabolism_Homo sapiens_hsa00230	0.92991380
33	DNA replication_Homo sapiens_hsa03030	0.92111385
34	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91995583
35	Cocaine addiction_Homo sapiens_hsa05030	0.91902538
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91901132
37	Phenylalanine metabolism_Homo sapiens_hsa00360	0.88687419
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88310029
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83158299
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82959943
41	Propanoate metabolism_Homo sapiens_hsa00640	0.81583145
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80584900
43	Morphine addiction_Homo sapiens_hsa05032	0.79233827
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.78807982
45	GABAergic synapse_Homo sapiens_hsa04727	0.78258541
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77880007
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77874690
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77696109
49	Base excision repair_Homo sapiens_hsa03410	0.74137602
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73875007
51	Fatty acid elongation_Homo sapiens_hsa00062	0.73045516
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72734715
53	Folate biosynthesis_Homo sapiens_hsa00790	0.72228661
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71512720
55	Metabolic pathways_Homo sapiens_hsa01100	0.71149662
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70790553
57	Butanoate metabolism_Homo sapiens_hsa00650	0.69991534
58	Nicotine addiction_Homo sapiens_hsa05033	0.69955604
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68148098
60	Homologous recombination_Homo sapiens_hsa03440	0.66531234
61	Taste transduction_Homo sapiens_hsa04742	0.66238719
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65983531
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.64897657
64	Glutathione metabolism_Homo sapiens_hsa00480	0.62706878
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60752506
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.59827415
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57189340
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.56551635
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53331013
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51991285
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51752669
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51275888
73	Serotonergic synapse_Homo sapiens_hsa04726	0.50598137
74	Sulfur relay system_Homo sapiens_hsa04122	0.49433247
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49349297
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47564730
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46895233
78	Regulation of autophagy_Homo sapiens_hsa04140	0.45682881
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.45380072
80	Olfactory transduction_Homo sapiens_hsa04740	0.44032233
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42953864
82	Axon guidance_Homo sapiens_hsa04360	0.40708617
83	Insulin secretion_Homo sapiens_hsa04911	0.40594779
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40221831
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37366438
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35583850
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.35180943
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.35123128
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.33941432
90	One carbon pool by folate_Homo sapiens_hsa00670	0.31268682
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.29940736
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.29546049
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29239552
94	Fatty acid degradation_Homo sapiens_hsa00071	0.26568227
95	Selenocompound metabolism_Homo sapiens_hsa00450	0.26354363
96	Amphetamine addiction_Homo sapiens_hsa05031	0.25293977
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24779258
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24343187
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.23710811
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23641631

CHCHD2P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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