

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.30616831 |
| 2 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.81114387 |
| 3 | protein complex biogenesis (GO:0070271) | 5.52002431 |
| 4 | viral transcription (GO:0019083) | 5.45298499 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 5.42546666 |
| 6 | respiratory electron transport chain (GO:0022904) | 5.41578362 |
| 7 | electron transport chain (GO:0022900) | 5.35901080 |
| 8 | translational termination (GO:0006415) | 5.31556348 |
| 9 | maturation of SSU-rRNA (GO:0030490) | 5.28665828 |
| 10 | proteasome assembly (GO:0043248) | 5.17070818 |
| 11 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.14147258 |
| 12 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.98749584 |
| 13 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.98749584 |
| 14 | NADH dehydrogenase complex assembly (GO:0010257) | 4.98749584 |
| 15 | ribosomal large subunit biogenesis (GO:0042273) | 4.93959547 |
| 16 | chaperone-mediated protein transport (GO:0072321) | 4.84566079 |
| 17 | respiratory chain complex IV assembly (GO:0008535) | 4.73391777 |
| 18 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.73185646 |
| 19 | translational elongation (GO:0006414) | 4.68951284 |
| 20 | cotranslational protein targeting to membrane (GO:0006613) | 4.67882953 |
| 21 | protein targeting to ER (GO:0045047) | 4.62240208 |
| 22 | DNA deamination (GO:0045006) | 4.59884886 |
| 23 | cytochrome complex assembly (GO:0017004) | 4.55488401 |
| 24 | translational initiation (GO:0006413) | 4.47298345 |
| 25 | protein localization to endoplasmic reticulum (GO:0070972) | 4.40837247 |
| 26 | protein neddylation (GO:0045116) | 4.40828333 |
| 27 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.36371925 |
| 28 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.32457444 |
| 29 | formation of translation preinitiation complex (GO:0001731) | 4.30181640 |
| 30 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.24375444 |
| 31 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.16306262 |
| 32 | viral life cycle (GO:0019058) | 4.16131084 |
| 33 | cellular protein complex disassembly (GO:0043624) | 4.16003052 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.15361135 |
| 35 | termination of RNA polymerase III transcription (GO:0006386) | 4.15361135 |
| 36 | translation (GO:0006412) | 4.14760410 |
| 37 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.10955274 |
| 38 | purine nucleobase biosynthetic process (GO:0009113) | 4.06234492 |
| 39 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.05889994 |
| 40 | termination of RNA polymerase I transcription (GO:0006363) | 4.05130524 |
| 41 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 4.05116351 |
| 42 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.02645114 |
| 43 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.01552221 |
| 44 | cullin deneddylation (GO:0010388) | 3.99331542 |
| 45 | negative regulation of ligase activity (GO:0051352) | 3.97044661 |
| 46 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.97044661 |
| 47 | nucleobase biosynthetic process (GO:0046112) | 3.97024927 |
| 48 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.94692479 |
| 49 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.88351893 |
| 50 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.86568934 |
| 51 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.86568934 |
| 52 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.86109150 |
| 53 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.86109150 |
| 54 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.86109150 |
| 55 | rRNA processing (GO:0006364) | 3.82741084 |
| 56 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.81856299 |
| 57 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.81856299 |
| 58 | 7-methylguanosine mRNA capping (GO:0006370) | 3.81671977 |
| 59 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.81240073 |
| 60 | rRNA modification (GO:0000154) | 3.80629902 |
| 61 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.80103412 |
| 62 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.80103412 |
| 63 | RNA capping (GO:0036260) | 3.76310782 |
| 64 | 7-methylguanosine RNA capping (GO:0009452) | 3.76310782 |
| 65 | transcription from RNA polymerase I promoter (GO:0006360) | 3.75279366 |
| 66 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.75224654 |
| 67 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.72600044 |
| 68 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.72526400 |
| 69 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.71393625 |
| 70 | hydrogen ion transmembrane transport (GO:1902600) | 3.70392657 |
| 71 | rRNA metabolic process (GO:0016072) | 3.68213388 |
| 72 | spliceosomal snRNP assembly (GO:0000387) | 3.66458490 |
| 73 | protein deneddylation (GO:0000338) | 3.66232846 |
| 74 | ATP biosynthetic process (GO:0006754) | 3.65966106 |
| 75 | cellular component biogenesis (GO:0044085) | 3.64012866 |
| 76 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.61210287 |
| 77 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.60386197 |
| 78 | protein complex disassembly (GO:0043241) | 3.60296147 |
| 79 | inner mitochondrial membrane organization (GO:0007007) | 3.59864093 |
| 80 | ATP synthesis coupled proton transport (GO:0015986) | 3.58238651 |
| 81 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.58238651 |
| 82 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.57599005 |
| 83 | ribosome assembly (GO:0042255) | 3.57153338 |
| 84 | ribosome biogenesis (GO:0042254) | 3.56741544 |
| 85 | pseudouridine synthesis (GO:0001522) | 3.56491464 |
| 86 | mannosylation (GO:0097502) | 3.55595095 |
| 87 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.54466351 |
| 88 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.54154917 |
| 89 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.51448246 |
| 90 | platelet dense granule organization (GO:0060155) | 3.50771537 |
| 91 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.47758367 |
| 92 | telomere maintenance via recombination (GO:0000722) | 3.45786210 |
| 93 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.44204556 |
| 94 | positive regulation of ligase activity (GO:0051351) | 3.44138953 |
| 95 | macromolecular complex disassembly (GO:0032984) | 3.43794714 |
| 96 | mitotic metaphase plate congression (GO:0007080) | 3.42521850 |
| 97 | DNA strand elongation (GO:0022616) | 3.42480671 |
| 98 | regulation of mitochondrial translation (GO:0070129) | 3.42327533 |
| 99 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.40633277 |
| 100 | proton transport (GO:0015992) | 3.38219457 |
| 101 | spliceosomal complex assembly (GO:0000245) | 3.33310607 |
| 102 | DNA replication checkpoint (GO:0000076) | 3.32767685 |
| 103 | hydrogen transport (GO:0006818) | 3.32064590 |
| 104 | protein-cofactor linkage (GO:0018065) | 3.31592832 |
| 105 | maturation of 5.8S rRNA (GO:0000460) | 3.28373808 |
| 106 | amino acid salvage (GO:0043102) | 3.20857843 |
| 107 | L-methionine salvage (GO:0071267) | 3.20857843 |
| 108 | L-methionine biosynthetic process (GO:0071265) | 3.20857843 |
| 109 | positive regulation of cell cycle arrest (GO:0071158) | 3.19467416 |
| 110 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.18730717 |
| 111 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.15924154 |
| 112 | DNA replication initiation (GO:0006270) | 3.14572483 |
| 113 | base-excision repair, AP site formation (GO:0006285) | 3.13476943 |
| 114 | aldehyde catabolic process (GO:0046185) | 3.12960139 |
| 115 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.11629518 |
| 116 | mitotic recombination (GO:0006312) | 3.10919798 |
| 117 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.10788246 |
| 118 | oxidative phosphorylation (GO:0006119) | 3.10730132 |
| 119 | intracellular protein transmembrane import (GO:0044743) | 3.09098619 |
| 120 | protein localization to mitochondrion (GO:0070585) | 3.08541133 |
| 121 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.07901867 |
| 122 | CENP-A containing nucleosome assembly (GO:0034080) | 3.05355189 |
| 123 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.04617935 |
| 124 | regulation of ligase activity (GO:0051340) | 3.04226591 |
| 125 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.02972532 |
| 126 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01477251 |
| 127 | GTP biosynthetic process (GO:0006183) | 3.00945123 |
| 128 | protein targeting to mitochondrion (GO:0006626) | 3.00935142 |
| 129 | protein targeting to membrane (GO:0006612) | 2.99116311 |
| 130 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.98496003 |
| 131 | cell cycle G1/S phase transition (GO:0044843) | 2.98496003 |
| 132 | viral mRNA export from host cell nucleus (GO:0046784) | 2.97933445 |
| 133 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.96127475 |
| 134 | peptidyl-histidine modification (GO:0018202) | 2.92575772 |
| 135 | ubiquinone biosynthetic process (GO:0006744) | 2.90427071 |
| 136 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.90386270 |
| 137 | sequestering of actin monomers (GO:0042989) | 2.88649689 |
| 138 | rRNA methylation (GO:0031167) | 2.87308202 |
| 139 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.85402704 |
| 140 | epithelial cilium movement (GO:0003351) | 2.83833550 |
| 141 | DNA damage response, detection of DNA damage (GO:0042769) | 2.82894936 |
| 142 | mitochondrial transport (GO:0006839) | 2.81039962 |
| 143 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.80779814 |
| 144 | tRNA processing (GO:0008033) | 2.79292677 |
| 145 | C-terminal protein lipidation (GO:0006501) | 2.75838739 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.44175991 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.40708321 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.11433594 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.92294808 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.84472541 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.81831629 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.56487654 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50299158 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.34328519 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.25499460 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.22694686 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.14986136 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.92823848 |
| 14 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.89335407 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.87629501 |
| 16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.83403363 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.82087524 |
| 18 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.68119091 |
| 19 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.53617580 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.51979836 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.48977950 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.46073239 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.44847220 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.40086552 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.39465352 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30064103 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.25758160 |
| 28 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.23454028 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.18932683 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12697969 |
| 31 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.11460755 |
| 32 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.10245443 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.09053346 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.00036863 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.99085341 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.98527081 |
| 37 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.93369875 |
| 38 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.92597184 |
| 39 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.92507350 |
| 40 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.89201816 |
| 41 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.87129673 |
| 42 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.86487502 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84112319 |
| 44 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.84058004 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.82777064 |
| 46 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70383016 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.67534223 |
| 48 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.65779252 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.60024998 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58327365 |
| 51 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56560908 |
| 52 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.52342096 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51050017 |
| 54 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48548618 |
| 55 | EWS_26573619_Chip-Seq_HEK293_Human | 1.47587363 |
| 56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47512985 |
| 57 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.46441199 |
| 58 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.45491688 |
| 59 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.41802643 |
| 60 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.38565028 |
| 61 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.37231220 |
| 62 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.34612754 |
| 63 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.33754729 |
| 64 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33606968 |
| 65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.32044045 |
| 66 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.31576500 |
| 67 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.31032765 |
| 68 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30706595 |
| 69 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.30168415 |
| 70 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.30035278 |
| 71 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.29262441 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.27228089 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22386412 |
| 74 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.21375537 |
| 75 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.19226391 |
| 76 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18453081 |
| 77 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.16623014 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16239734 |
| 79 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.15922274 |
| 80 | AR_20517297_ChIP-Seq_VCAP_Human | 1.15222646 |
| 81 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14442769 |
| 82 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12762964 |
| 83 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.10479516 |
| 84 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.09888288 |
| 85 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.09790784 |
| 86 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.08682003 |
| 87 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.07519415 |
| 88 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.07519415 |
| 89 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.07433164 |
| 90 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.05938059 |
| 91 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.05432181 |
| 92 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.03811460 |
| 93 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03429220 |
| 94 | * PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.03217384 |
| 95 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.02607959 |
| 96 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.02441170 |
| 97 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.01406667 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.00238417 |
| 99 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.98752452 |
| 100 | * SOX2_19829295_ChIP-Seq_ESCs_Human | 0.98745668 |
| 101 | * NANOG_19829295_ChIP-Seq_ESCs_Human | 0.98745668 |
| 102 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.98155150 |
| 103 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.97956848 |
| 104 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97241897 |
| 105 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97179545 |
| 106 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.96804546 |
| 107 | * MYC_18940864_ChIP-ChIP_HL60_Human | 0.96722041 |
| 108 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.95993876 |
| 109 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.95409560 |
| 110 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.94596409 |
| 111 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.94580329 |
| 112 | * GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.94343156 |
| 113 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.93985313 |
| 114 | NCOR_22424771_ChIP-Seq_293T_Human | 0.93238101 |
| 115 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93031214 |
| 116 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92585420 |
| 117 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.92228069 |
| 118 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.90656041 |
| 119 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.89902603 |
| 120 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.89882347 |
| 121 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89258976 |
| 122 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.88258127 |
| 123 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88172855 |
| 124 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.87826698 |
| 125 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87691569 |
| 126 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.87416910 |
| 127 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85982283 |
| 128 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85227710 |
| 129 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.84842609 |
| 130 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.84765247 |
| 131 | ERA_21632823_ChIP-Seq_H3396_Human | 0.84356925 |
| 132 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.84084941 |
| 133 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.83931837 |
| 134 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.83471680 |
| 135 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.83305221 |
| 136 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.83253018 |
| 137 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.82162414 |
| 138 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.80004634 |
| 139 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.79660332 |
| 140 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.79462196 |
| 141 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.77291597 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.40372396 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.25745620 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.48863412 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.34976319 |
| 5 | MP0003077_abnormal_cell_cycle | 3.29871095 |
| 6 | MP0000372_irregular_coat_pigmentation | 3.26053666 |
| 7 | MP0010094_abnormal_chromosome_stability | 3.23215525 |
| 8 | MP0008058_abnormal_DNA_repair | 3.11272433 |
| 9 | MP0008057_abnormal_DNA_replication | 2.80991889 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.76909847 |
| 11 | MP0003786_premature_aging | 2.74386573 |
| 12 | MP0009379_abnormal_foot_pigmentation | 2.66446181 |
| 13 | MP0003718_maternal_effect | 2.65463239 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.63402270 |
| 15 | MP0002837_dystrophic_cardiac_calcinosis | 2.57629219 |
| 16 | MP0003186_abnormal_redox_activity | 2.46332775 |
| 17 | MP0008007_abnormal_cellular_replicative | 2.36874306 |
| 18 | MP0003195_calcinosis | 2.34142264 |
| 19 | MP0001529_abnormal_vocalization | 2.23806419 |
| 20 | MP0006292_abnormal_olfactory_placode | 2.10949555 |
| 21 | MP0002938_white_spotting | 2.10190373 |
| 22 | MP0002102_abnormal_ear_morphology | 2.07224732 |
| 23 | MP0005084_abnormal_gallbladder_morpholo | 1.98654928 |
| 24 | MP0003011_delayed_dark_adaptation | 1.90863535 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.88679870 |
| 26 | MP0008995_early_reproductive_senescence | 1.83396409 |
| 27 | MP0003123_paternal_imprinting | 1.80538849 |
| 28 | MP0008260_abnormal_autophagy | 1.80163168 |
| 29 | MP0005551_abnormal_eye_electrophysiolog | 1.77215641 |
| 30 | MP0002736_abnormal_nociception_after | 1.75961205 |
| 31 | MP0004142_abnormal_muscle_tone | 1.71354407 |
| 32 | MP0005253_abnormal_eye_physiology | 1.69623199 |
| 33 | MP0001968_abnormal_touch/_nociception | 1.67656644 |
| 34 | MP0002653_abnormal_ependyma_morphology | 1.66874054 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.64462873 |
| 36 | MP0008872_abnormal_physiological_respon | 1.63048708 |
| 37 | MP0005379_endocrine/exocrine_gland_phen | 1.61694880 |
| 38 | MP0008875_abnormal_xenobiotic_pharmacok | 1.60782136 |
| 39 | MP0005646_abnormal_pituitary_gland | 1.60612487 |
| 40 | MP0003315_abnormal_perineum_morphology | 1.56636390 |
| 41 | MP0005075_abnormal_melanosome_morpholog | 1.56112824 |
| 42 | MP0001730_embryonic_growth_arrest | 1.53585027 |
| 43 | MP0001905_abnormal_dopamine_level | 1.52940110 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.52103577 |
| 45 | MP0002638_abnormal_pupillary_reflex | 1.51002400 |
| 46 | MP0003941_abnormal_skin_development | 1.50808630 |
| 47 | MP0004133_heterotaxia | 1.50696721 |
| 48 | MP0009333_abnormal_splenocyte_physiolog | 1.50229947 |
| 49 | MP0003950_abnormal_plasma_membrane | 1.48959456 |
| 50 | MP0003136_yellow_coat_color | 1.48798975 |
| 51 | MP0000566_synostosis | 1.47450613 |
| 52 | MP0001764_abnormal_homeostasis | 1.47243578 |
| 53 | MP0001853_heart_inflammation | 1.46350156 |
| 54 | MP0010386_abnormal_urinary_bladder | 1.43054096 |
| 55 | MP0001984_abnormal_olfaction | 1.42042061 |
| 56 | MP0000490_abnormal_crypts_of | 1.40237933 |
| 57 | MP0000350_abnormal_cell_proliferation | 1.37518803 |
| 58 | MP0001542_abnormal_bone_strength | 1.33977198 |
| 59 | MP0003880_abnormal_central_pattern | 1.31799095 |
| 60 | MP0009697_abnormal_copulation | 1.31467570 |
| 61 | MP0001293_anophthalmia | 1.29034578 |
| 62 | MP0002160_abnormal_reproductive_system | 1.29031100 |
| 63 | MP0002132_abnormal_respiratory_system | 1.25349115 |
| 64 | MP0006276_abnormal_autonomic_nervous | 1.22605184 |
| 65 | MP0009046_muscle_twitch | 1.22340767 |
| 66 | MP0000631_abnormal_neuroendocrine_gland | 1.21591290 |
| 67 | MP0002396_abnormal_hematopoietic_system | 1.21555927 |
| 68 | MP0006035_abnormal_mitochondrial_morpho | 1.20855961 |
| 69 | MP0003646_muscle_fatigue | 1.20279053 |
| 70 | MP0000313_abnormal_cell_death | 1.19600564 |
| 71 | MP0002148_abnormal_hypersensitivity_rea | 1.17732104 |
| 72 | MP0002876_abnormal_thyroid_physiology | 1.16918807 |
| 73 | MP0005389_reproductive_system_phenotype | 1.14687063 |
| 74 | MP0003787_abnormal_imprinting | 1.14684313 |
| 75 | MP0005174_abnormal_tail_pigmentation | 1.13658673 |
| 76 | MP0002234_abnormal_pharynx_morphology | 1.11238098 |
| 77 | MP0002080_prenatal_lethality | 1.10426794 |
| 78 | MP0009745_abnormal_behavioral_response | 1.09878467 |
| 79 | MP0000358_abnormal_cell_content/ | 1.09185539 |
| 80 | MP0005380_embryogenesis_phenotype | 1.09041738 |
| 81 | MP0001672_abnormal_embryogenesis/_devel | 1.09041738 |
| 82 | MP0010030_abnormal_orbit_morphology | 1.06937402 |
| 83 | MP0001485_abnormal_pinna_reflex | 1.06926714 |
| 84 | MP0005410_abnormal_fertilization | 1.05931725 |
| 85 | MP0001697_abnormal_embryo_size | 1.05857431 |
| 86 | MP0003121_genomic_imprinting | 1.02916504 |
| 87 | MP0005266_abnormal_metabolism | 1.02820209 |
| 88 | MP0003122_maternal_imprinting | 1.01827082 |
| 89 | MP0002822_catalepsy | 1.01787425 |
| 90 | MP0002095_abnormal_skin_pigmentation | 0.96827410 |
| 91 | MP0009840_abnormal_foam_cell | 0.96685465 |
| 92 | MP0002090_abnormal_vision | 0.94787241 |
| 93 | MP0009785_altered_susceptibility_to | 0.94300524 |
| 94 | MP0002019_abnormal_tumor_incidence | 0.92974303 |
| 95 | MP0001835_abnormal_antigen_presentation | 0.92808868 |
| 96 | MP0001919_abnormal_reproductive_system | 0.92105095 |
| 97 | MP0003984_embryonic_growth_retardation | 0.91569040 |
| 98 | MP0002088_abnormal_embryonic_growth/wei | 0.89808276 |
| 99 | MP0005395_other_phenotype | 0.89718947 |
| 100 | MP0002272_abnormal_nervous_system | 0.89511326 |
| 101 | MP0001727_abnormal_embryo_implantation | 0.89461236 |
| 102 | MP0005499_abnormal_olfactory_system | 0.89454626 |
| 103 | MP0005394_taste/olfaction_phenotype | 0.89454626 |
| 104 | MP0009053_abnormal_anal_canal | 0.89331206 |
| 105 | MP0004742_abnormal_vestibular_system | 0.89183414 |
| 106 | MP0000689_abnormal_spleen_morphology | 0.88944211 |
| 107 | MP0005636_abnormal_mineral_homeostasis | 0.87861604 |
| 108 | MP0001986_abnormal_taste_sensitivity | 0.86074747 |
| 109 | MP0001324_abnormal_eye_pigmentation | 0.85760274 |
| 110 | MP0002085_abnormal_embryonic_tissue | 0.85502165 |
| 111 | MP0001929_abnormal_gametogenesis | 0.84870804 |
| 112 | MP0002210_abnormal_sex_determination | 0.84280791 |
| 113 | MP0004043_abnormal_pH_regulation | 0.84019394 |
| 114 | MP0002277_abnormal_respiratory_mucosa | 0.83231482 |
| 115 | MP0002722_abnormal_immune_system | 0.82316324 |
| 116 | MP0002693_abnormal_pancreas_physiology | 0.80481595 |
| 117 | MP0005195_abnormal_posterior_eye | 0.79213380 |
| 118 | MP0008789_abnormal_olfactory_epithelium | 0.79150686 |
| 119 | MP0000026_abnormal_inner_ear | 0.77850383 |
| 120 | MP0005408_hypopigmentation | 0.77535104 |
| 121 | MP0004782_abnormal_surfactant_physiolog | 0.76880644 |
| 122 | MP0003283_abnormal_digestive_organ | 0.76808988 |
| 123 | MP0002557_abnormal_social/conspecific_i | 0.75593515 |
| 124 | MP0005397_hematopoietic_system_phenotyp | 0.75290355 |
| 125 | MP0001545_abnormal_hematopoietic_system | 0.75290355 |
| 126 | MP0000653_abnormal_sex_gland | 0.74481291 |
| 127 | MP0004147_increased_porphyrin_level | 0.74259452 |
| 128 | MP0001119_abnormal_female_reproductive | 0.73720117 |
| 129 | MP0005376_homeostasis/metabolism_phenot | 0.73625307 |
| 130 | MP0002735_abnormal_chemical_nociception | 0.73263018 |
| 131 | MP0001756_abnormal_urination | 0.72522104 |
| 132 | MP0002282_abnormal_trachea_morphology | 0.72179720 |
| 133 | MP0000750_abnormal_muscle_regeneration | 0.71783889 |
| 134 | MP0003119_abnormal_digestive_system | 0.71781307 |
| 135 | MP0003137_abnormal_impulse_conducting | 0.71577451 |
| 136 | MP0001145_abnormal_male_reproductive | 0.71572861 |
| 137 | MP0004885_abnormal_endolymph | 0.71160182 |
| 138 | MP0005377_hearing/vestibular/ear_phenot | 0.71153572 |
| 139 | MP0003878_abnormal_ear_physiology | 0.71153572 |
| 140 | MP0002139_abnormal_hepatobiliary_system | 0.71055999 |
| 141 | MP0002751_abnormal_autonomic_nervous | 0.70894256 |
| 142 | MP0004145_abnormal_muscle_electrophysio | 0.70328030 |
| 143 | MP0005671_abnormal_response_to | 0.70157159 |
| 144 | MP0005391_vision/eye_phenotype | 0.69390726 |
| 145 | MP0005332_abnormal_amino_acid | 0.68411347 |
| 146 | MP0002332_abnormal_exercise_endurance | 0.67957341 |
| 147 | MP0002086_abnormal_extraembryonic_tissu | 0.67275518 |
| 148 | MP0001286_abnormal_eye_development | 0.66036171 |
| 149 | MP0003936_abnormal_reproductive_system | 0.65919020 |
| 150 | MP0008877_abnormal_DNA_methylation | 0.65085212 |
| 151 | MP0002084_abnormal_developmental_patter | 0.64844269 |
| 152 | MP0002111_abnormal_tail_morphology | 0.64589857 |
| 153 | MP0002163_abnormal_gland_morphology | 0.63403105 |
| 154 | MP0002429_abnormal_blood_cell | 0.62057475 |
| 155 | MP0004019_abnormal_vitamin_homeostasis | 0.59170988 |
| 156 | MP0002398_abnormal_bone_marrow | 0.58241840 |
| 157 | MP0005501_abnormal_skin_physiology | 0.57215998 |
| 158 | MP0005025_abnormal_response_to | 0.55951962 |
| 159 | MP0004381_abnormal_hair_follicle | 0.54311579 |
| 160 | MP0004084_abnormal_cardiac_muscle | 0.54113864 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.94421103 |
| 2 | Reticulocytopenia (HP:0001896) | 4.81501984 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 4.31245262 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.30786098 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.90796317 |
| 6 | 3-Methylglutaconic aciduria (HP:0003535) | 3.85637417 |
| 7 | Macrocytic anemia (HP:0001972) | 3.80246138 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.78219596 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.74886186 |
| 10 | Cerebral hypomyelination (HP:0006808) | 3.56395267 |
| 11 | Acute encephalopathy (HP:0006846) | 3.54313809 |
| 12 | Hepatic necrosis (HP:0002605) | 3.48876274 |
| 13 | Increased CSF lactate (HP:0002490) | 3.47708891 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.43115376 |
| 15 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.31936490 |
| 16 | Progressive macrocephaly (HP:0004481) | 3.31197166 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.29637741 |
| 18 | Birth length less than 3rd percentile (HP:0003561) | 3.26615946 |
| 19 | Oral leukoplakia (HP:0002745) | 3.26427024 |
| 20 | Breast hypoplasia (HP:0003187) | 3.23570237 |
| 21 | Pancreatic fibrosis (HP:0100732) | 3.18921161 |
| 22 | Abnormality of midbrain morphology (HP:0002418) | 3.18141710 |
| 23 | Molar tooth sign on MRI (HP:0002419) | 3.18141710 |
| 24 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15582046 |
| 25 | Pallor (HP:0000980) | 3.09582143 |
| 26 | Renal Fanconi syndrome (HP:0001994) | 3.08054417 |
| 27 | Lipid accumulation in hepatocytes (HP:0006561) | 3.05492849 |
| 28 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.99277376 |
| 29 | Increased serum lactate (HP:0002151) | 2.95055795 |
| 30 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.90499668 |
| 31 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.90499668 |
| 32 | Rough bone trabeculation (HP:0100670) | 2.87830710 |
| 33 | True hermaphroditism (HP:0010459) | 2.87530391 |
| 34 | Degeneration of anterior horn cells (HP:0002398) | 2.78649583 |
| 35 | Abnormality of the anterior horn cell (HP:0006802) | 2.78649583 |
| 36 | Cerebral edema (HP:0002181) | 2.75263835 |
| 37 | Aplastic anemia (HP:0001915) | 2.68003053 |
| 38 | Exertional dyspnea (HP:0002875) | 2.67190970 |
| 39 | Multiple enchondromatosis (HP:0005701) | 2.66667693 |
| 40 | Nephronophthisis (HP:0000090) | 2.63563556 |
| 41 | Medial flaring of the eyebrow (HP:0010747) | 2.63031715 |
| 42 | Exercise intolerance (HP:0003546) | 2.60833847 |
| 43 | Methylmalonic acidemia (HP:0002912) | 2.53089512 |
| 44 | Methylmalonic aciduria (HP:0012120) | 2.51052016 |
| 45 | Type I transferrin isoform profile (HP:0003642) | 2.46911938 |
| 46 | Lactic acidosis (HP:0003128) | 2.46466470 |
| 47 | Absent thumb (HP:0009777) | 2.45298286 |
| 48 | Carpal bone hypoplasia (HP:0001498) | 2.44534119 |
| 49 | Hyperglycinemia (HP:0002154) | 2.42369821 |
| 50 | Glycosuria (HP:0003076) | 2.41678850 |
| 51 | Abnormality of urine glucose concentration (HP:0011016) | 2.41678850 |
| 52 | Cleft eyelid (HP:0000625) | 2.41444862 |
| 53 | Respiratory failure (HP:0002878) | 2.40840730 |
| 54 | Patellar aplasia (HP:0006443) | 2.36091381 |
| 55 | Abnormality of glycolysis (HP:0004366) | 2.34524041 |
| 56 | Increased serum pyruvate (HP:0003542) | 2.34524041 |
| 57 | Meckel diverticulum (HP:0002245) | 2.33878272 |
| 58 | Abnormality of the preputium (HP:0100587) | 2.32728510 |
| 59 | Respiratory difficulties (HP:0002880) | 2.32372458 |
| 60 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.30638333 |
| 61 | Abnormal protein glycosylation (HP:0012346) | 2.29532284 |
| 62 | Abnormal glycosylation (HP:0012345) | 2.29532284 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.29532284 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.29532284 |
| 65 | CNS demyelination (HP:0007305) | 2.29025502 |
| 66 | Generalized aminoaciduria (HP:0002909) | 2.23174580 |
| 67 | Increased intramyocellular lipid droplets (HP:0012240) | 2.22623022 |
| 68 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.22254614 |
| 69 | Congenital stationary night blindness (HP:0007642) | 2.21310756 |
| 70 | Microvesicular hepatic steatosis (HP:0001414) | 2.20632107 |
| 71 | Sparse eyelashes (HP:0000653) | 2.19677963 |
| 72 | Premature ovarian failure (HP:0008209) | 2.19651532 |
| 73 | Colon cancer (HP:0003003) | 2.19119437 |
| 74 | Secondary amenorrhea (HP:0000869) | 2.17385467 |
| 75 | Abnormality of the ileum (HP:0001549) | 2.16845240 |
| 76 | Triphalangeal thumb (HP:0001199) | 2.16072657 |
| 77 | Abnormality of the renal medulla (HP:0100957) | 2.15120768 |
| 78 | Cellular immunodeficiency (HP:0005374) | 2.14821133 |
| 79 | Absent radius (HP:0003974) | 2.14760057 |
| 80 | Poor head control (HP:0002421) | 2.14410486 |
| 81 | Microretrognathia (HP:0000308) | 2.13778202 |
| 82 | Abnormality of the renal cortex (HP:0011035) | 2.13434478 |
| 83 | Abnormal trabecular bone morphology (HP:0100671) | 2.12862647 |
| 84 | Abnormality of the labia minora (HP:0012880) | 2.11406984 |
| 85 | Leukodystrophy (HP:0002415) | 2.10563068 |
| 86 | Lethargy (HP:0001254) | 2.05590565 |
| 87 | Premature graying of hair (HP:0002216) | 2.05336830 |
| 88 | Pancytopenia (HP:0001876) | 2.04716500 |
| 89 | Sclerocornea (HP:0000647) | 2.03947311 |
| 90 | CNS hypomyelination (HP:0003429) | 2.02654531 |
| 91 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.02254014 |
| 92 | Dicarboxylic aciduria (HP:0003215) | 2.02254014 |
| 93 | Bone marrow hypocellularity (HP:0005528) | 2.02027282 |
| 94 | Congenital primary aphakia (HP:0007707) | 2.01274543 |
| 95 | Hypoplasia of the radius (HP:0002984) | 2.00249968 |
| 96 | Pancreatic cysts (HP:0001737) | 1.98902945 |
| 97 | Trismus (HP:0000211) | 1.98870640 |
| 98 | Aplasia involving forearm bones (HP:0009822) | 1.98240599 |
| 99 | Absent forearm bone (HP:0003953) | 1.98240599 |
| 100 | Optic disc pallor (HP:0000543) | 1.97878508 |
| 101 | Hypothermia (HP:0002045) | 1.97269130 |
| 102 | Large for gestational age (HP:0001520) | 1.97056812 |
| 103 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.96769913 |
| 104 | Selective tooth agenesis (HP:0001592) | 1.96612919 |
| 105 | Gait imbalance (HP:0002141) | 1.95343103 |
| 106 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.94753742 |
| 107 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.94753742 |
| 108 | Pendular nystagmus (HP:0012043) | 1.93976670 |
| 109 | Prolonged neonatal jaundice (HP:0006579) | 1.93893512 |
| 110 | Renal cortical cysts (HP:0000803) | 1.93497121 |
| 111 | Nausea (HP:0002018) | 1.93421873 |
| 112 | Stenosis of the external auditory canal (HP:0000402) | 1.92953552 |
| 113 | Abnormality of the umbilical cord (HP:0010881) | 1.92533337 |
| 114 | Cystic liver disease (HP:0006706) | 1.92281178 |
| 115 | Nephrogenic diabetes insipidus (HP:0009806) | 1.92088893 |
| 116 | Hyperphosphaturia (HP:0003109) | 1.90963890 |
| 117 | Abnormality of renal resorption (HP:0011038) | 1.89665737 |
| 118 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89320795 |
| 119 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.88289591 |
| 120 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.87398749 |
| 121 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.87195707 |
| 122 | Thrombocytosis (HP:0001894) | 1.86071827 |
| 123 | Impulsivity (HP:0100710) | 1.86008308 |
| 124 | Emotional lability (HP:0000712) | 1.85655698 |
| 125 | Horseshoe kidney (HP:0000085) | 1.85103999 |
| 126 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.83556546 |
| 127 | Abnormality of the pons (HP:0007361) | 1.83369754 |
| 128 | Increased muscle lipid content (HP:0009058) | 1.81833494 |
| 129 | Type II lissencephaly (HP:0007260) | 1.81551765 |
| 130 | Abnormal biliary tract physiology (HP:0012439) | 1.80702583 |
| 131 | Bile duct proliferation (HP:0001408) | 1.80702583 |
| 132 | Spastic paraparesis (HP:0002313) | 1.80437704 |
| 133 | X-linked dominant inheritance (HP:0001423) | 1.78523739 |
| 134 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.78480196 |
| 135 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.78480196 |
| 136 | Single umbilical artery (HP:0001195) | 1.78480196 |
| 137 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.78408322 |
| 138 | Anencephaly (HP:0002323) | 1.78349422 |
| 139 | Entropion (HP:0000621) | 1.77916672 |
| 140 | Intestinal atresia (HP:0011100) | 1.77457655 |
| 141 | Severe visual impairment (HP:0001141) | 1.76948654 |
| 142 | 11 pairs of ribs (HP:0000878) | 1.76364331 |
| 143 | Abnormal ciliary motility (HP:0012262) | 1.75622860 |
| 144 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.75165165 |
| 145 | Death in infancy (HP:0001522) | 1.75086054 |
| 146 | Reduced antithrombin III activity (HP:0001976) | 1.74719740 |
| 147 | Hypoplasia of the pons (HP:0012110) | 1.74264050 |
| 148 | Chromsome breakage (HP:0040012) | 1.72326643 |
| 149 | Male pseudohermaphroditism (HP:0000037) | 1.70595896 |
| 150 | Ketosis (HP:0001946) | 1.69896330 |
| 151 | Ketoacidosis (HP:0001993) | 1.67087764 |
| 152 | Abolished electroretinogram (ERG) (HP:0000550) | 1.66822954 |
| 153 | Abnormality of methionine metabolism (HP:0010901) | 1.66333349 |
| 154 | Hyperglycinuria (HP:0003108) | 1.66073321 |
| 155 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.65888492 |
| 156 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.64447146 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.24595736 |
| 2 | BUB1 | 4.98850755 |
| 3 | NME2 | 4.03658198 |
| 4 | WEE1 | 3.73913347 |
| 5 | EIF2AK1 | 3.49010467 |
| 6 | MAP4K2 | 3.19627747 |
| 7 | STK16 | 3.07084748 |
| 8 | PLK4 | 2.53031918 |
| 9 | TLK1 | 2.46021496 |
| 10 | WNK3 | 2.44455596 |
| 11 | EPHA2 | 2.42072850 |
| 12 | NUAK1 | 2.36067925 |
| 13 | FRK | 2.32862763 |
| 14 | TAOK3 | 2.32372298 |
| 15 | EIF2AK3 | 2.23977156 |
| 16 | SRPK1 | 2.17861511 |
| 17 | VRK1 | 2.14936188 |
| 18 | TSSK6 | 2.04792817 |
| 19 | BCKDK | 1.99807293 |
| 20 | PIM2 | 1.93360996 |
| 21 | ZAK | 1.83900432 |
| 22 | TRIM28 | 1.82517034 |
| 23 | GRK1 | 1.76685554 |
| 24 | BRAF | 1.69636511 |
| 25 | BRSK2 | 1.66219779 |
| 26 | PBK | 1.62127572 |
| 27 | CDC7 | 1.52991524 |
| 28 | NME1 | 1.51963205 |
| 29 | ACVR1B | 1.49925550 |
| 30 | IRAK3 | 1.49890124 |
| 31 | NEK2 | 1.48739690 |
| 32 | TTK | 1.47280093 |
| 33 | PLK1 | 1.47044598 |
| 34 | RPS6KB2 | 1.37818144 |
| 35 | AURKB | 1.35840873 |
| 36 | NEK1 | 1.32924237 |
| 37 | MKNK1 | 1.26513545 |
| 38 | TAF1 | 1.25346227 |
| 39 | AURKA | 1.21838361 |
| 40 | INSRR | 1.15926242 |
| 41 | CDK7 | 1.15296157 |
| 42 | BRSK1 | 1.13414130 |
| 43 | AKT3 | 1.11652114 |
| 44 | EIF2AK2 | 1.11077733 |
| 45 | CSNK1G3 | 1.10359521 |
| 46 | MKNK2 | 1.10022517 |
| 47 | PLK3 | 1.06258335 |
| 48 | TESK2 | 1.05277676 |
| 49 | WNK4 | 1.04532620 |
| 50 | DYRK3 | 1.04425396 |
| 51 | MYLK | 1.03909499 |
| 52 | TNIK | 1.00289622 |
| 53 | MST4 | 0.98466583 |
| 54 | CSNK1G1 | 0.95992203 |
| 55 | CSNK1G2 | 0.94068198 |
| 56 | ARAF | 0.93947549 |
| 57 | RPS6KA5 | 0.92654758 |
| 58 | TGFBR1 | 0.91797541 |
| 59 | MAPKAPK3 | 0.91712492 |
| 60 | CASK | 0.90852261 |
| 61 | MAP3K12 | 0.90847242 |
| 62 | MAP2K7 | 0.90574390 |
| 63 | MAP3K8 | 0.90422004 |
| 64 | RPS6KA4 | 0.87763272 |
| 65 | DYRK2 | 0.87507194 |
| 66 | MAPK13 | 0.87118842 |
| 67 | MAP3K4 | 0.86127617 |
| 68 | ATR | 0.85402110 |
| 69 | STK24 | 0.83871460 |
| 70 | TESK1 | 0.83338425 |
| 71 | BLK | 0.81758438 |
| 72 | CSNK2A1 | 0.81652945 |
| 73 | MAP3K11 | 0.80579311 |
| 74 | LIMK1 | 0.78284331 |
| 75 | PHKG1 | 0.77744661 |
| 76 | PHKG2 | 0.77744661 |
| 77 | STK4 | 0.76335866 |
| 78 | MAP2K6 | 0.76134605 |
| 79 | PASK | 0.75978674 |
| 80 | PINK1 | 0.75631429 |
| 81 | PIM1 | 0.75561150 |
| 82 | MUSK | 0.75471751 |
| 83 | PDK2 | 0.74429097 |
| 84 | STK38L | 0.74198828 |
| 85 | CSNK1A1L | 0.73957119 |
| 86 | IRAK4 | 0.73852427 |
| 87 | NEK9 | 0.72967232 |
| 88 | OXSR1 | 0.71572565 |
| 89 | KDR | 0.71301412 |
| 90 | IKBKB | 0.71213124 |
| 91 | CSNK2A2 | 0.69908875 |
| 92 | TAOK2 | 0.69642911 |
| 93 | PAK1 | 0.69327276 |
| 94 | PRKCI | 0.69238818 |
| 95 | KIT | 0.66371950 |
| 96 | OBSCN | 0.65905044 |
| 97 | PRKCG | 0.65733730 |
| 98 | TIE1 | 0.64695732 |
| 99 | ILK | 0.63352387 |
| 100 | CHEK2 | 0.63271211 |
| 101 | CDK19 | 0.62684250 |
| 102 | ADRBK1 | 0.61822138 |
| 103 | PAK4 | 0.60080477 |
| 104 | MAP2K2 | 0.59516102 |
| 105 | ABL2 | 0.59443575 |
| 106 | IRAK2 | 0.57812239 |
| 107 | CDK8 | 0.57100591 |
| 108 | PLK2 | 0.55002450 |
| 109 | PRKCE | 0.54984046 |
| 110 | DAPK1 | 0.49293375 |
| 111 | CHEK1 | 0.49137906 |
| 112 | TXK | 0.46991665 |
| 113 | STK10 | 0.46002259 |
| 114 | CCNB1 | 0.45087266 |
| 115 | BMPR1B | 0.44755471 |
| 116 | FGFR2 | 0.44140725 |
| 117 | PAK3 | 0.43348989 |
| 118 | CSNK1A1 | 0.43225974 |
| 119 | ADRBK2 | 0.42504448 |
| 120 | MAP3K3 | 0.41530351 |
| 121 | BCR | 0.41201761 |
| 122 | DAPK3 | 0.40592461 |
| 123 | EPHB2 | 0.39953523 |
| 124 | STK39 | 0.39863722 |
| 125 | DAPK2 | 0.38860351 |
| 126 | FLT3 | 0.38806580 |
| 127 | MAPKAPK5 | 0.37621108 |
| 128 | PRKCQ | 0.37470852 |
| 129 | LRRK2 | 0.37400408 |
| 130 | YES1 | 0.37166063 |
| 131 | TNK2 | 0.36838755 |
| 132 | PNCK | 0.35999696 |
| 133 | GRK7 | 0.35553682 |
| 134 | PRKACA | 0.35443608 |
| 135 | MAP4K1 | 0.34268152 |
| 136 | MATK | 0.34227378 |
| 137 | MAPKAPK2 | 0.32835459 |
| 138 | MARK3 | 0.32615040 |
| 139 | CDK2 | 0.32578672 |
| 140 | GRK5 | 0.32555497 |
| 141 | CLK1 | 0.29633075 |
| 142 | CHUK | 0.28307930 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.01038817 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.69673423 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.07949953 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.47587619 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.15996369 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.92470772 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.65986998 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.60299377 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.51421605 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.46841357 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.44613397 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.30460990 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 2.25042387 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.08472770 |
| 15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.95496355 |
| 16 | Protein export_Homo sapiens_hsa03060 | 1.91549311 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.89508250 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.84426114 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.78506677 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.70895153 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.70029789 |
| 22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.67135674 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.45405158 |
| 24 | Cell cycle_Homo sapiens_hsa04110 | 1.45270006 |
| 25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.42457919 |
| 26 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.41733972 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.41339691 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.39180418 |
| 29 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.38252427 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.36882791 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.31697205 |
| 32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.28237814 |
| 33 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.13233927 |
| 34 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.10014173 |
| 35 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.07206290 |
| 36 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.01017395 |
| 37 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.99945189 |
| 38 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.98679635 |
| 39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98667021 |
| 40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.97181365 |
| 41 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.95914254 |
| 42 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.94395439 |
| 43 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.94067110 |
| 44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.92535494 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92225262 |
| 46 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.91571928 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.89533610 |
| 48 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.88648929 |
| 49 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.86127003 |
| 50 | Sulfur relay system_Homo sapiens_hsa04122 | 0.83611762 |
| 51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.83372744 |
| 52 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83299371 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.81838327 |
| 54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.80254627 |
| 55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.79796975 |
| 56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.77947518 |
| 57 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.73787369 |
| 58 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.69888909 |
| 59 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.69322807 |
| 60 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.68988497 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68693691 |
| 62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67864170 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.66861278 |
| 64 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.66849010 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.66668719 |
| 66 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.66128044 |
| 67 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.66049101 |
| 68 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.64461543 |
| 69 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.62893742 |
| 70 | Asthma_Homo sapiens_hsa05310 | 0.60473968 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.59811973 |
| 72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.59744679 |
| 73 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.59391863 |
| 74 | Allograft rejection_Homo sapiens_hsa05330 | 0.53467223 |
| 75 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.51509880 |
| 76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.51298304 |
| 77 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.51036063 |
| 78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49320998 |
| 79 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49222197 |
| 80 | Legionellosis_Homo sapiens_hsa05134 | 0.48995203 |
| 81 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.48651685 |
| 82 | Phototransduction_Homo sapiens_hsa04744 | 0.44350129 |
| 83 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43830675 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43783968 |
| 85 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42394356 |
| 86 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.41310579 |
| 87 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.41208667 |
| 88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.41175495 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.40864954 |
| 90 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.38319187 |
| 91 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38203605 |
| 92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.36870784 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36646473 |
| 94 | Other glycan degradation_Homo sapiens_hsa00511 | 0.36327574 |
| 95 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.35718001 |
| 96 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.34658654 |
| 97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.34012859 |
| 98 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.33654107 |
| 99 | Olfactory transduction_Homo sapiens_hsa04740 | 0.33364730 |
| 100 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.31802899 |
| 101 | Peroxisome_Homo sapiens_hsa04146 | 0.31657832 |
| 102 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.29431142 |
| 103 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.27287710 |
| 104 | Mineral absorption_Homo sapiens_hsa04978 | 0.26967539 |
| 105 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.26907175 |
| 106 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.26902837 |
| 107 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.26174191 |
| 108 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.25849626 |
| 109 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.25383640 |
| 110 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.25377634 |
| 111 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24910963 |
| 112 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.24147962 |
| 113 | Nicotine addiction_Homo sapiens_hsa05033 | 0.23342312 |
| 114 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22792462 |
| 115 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.22264117 |
| 116 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.20022016 |
| 117 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.19861944 |
| 118 | Thyroid cancer_Homo sapiens_hsa05216 | 0.19302605 |
| 119 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.18592671 |
| 120 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.18157297 |
| 121 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17082566 |
| 122 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.16933163 |
| 123 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.16128415 |
| 124 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.15911120 |
| 125 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.15628627 |
| 126 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.14096097 |
| 127 | HTLV-I infection_Homo sapiens_hsa05166 | 0.12924169 |
| 128 | Apoptosis_Homo sapiens_hsa04210 | 0.12345027 |

