CHCHD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.43445044
2ATP synthesis coupled proton transport (GO:0015986)5.11656191
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.11656191
4melanin biosynthetic process (GO:0042438)4.79573438
5chaperone-mediated protein transport (GO:0072321)4.49407178
6secondary metabolite biosynthetic process (GO:0044550)4.42675077
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42301119
8GTP biosynthetic process (GO:0006183)4.22659209
9melanin metabolic process (GO:0006582)4.20080612
10guanosine-containing compound biosynthetic process (GO:1901070)4.12491781
11protein localization to cilium (GO:0061512)4.03104102
12pyrimidine nucleobase catabolic process (GO:0006208)4.00767754
13respiratory electron transport chain (GO:0022904)3.98687828
14electron transport chain (GO:0022900)3.95952505
15regulation of cilium movement (GO:0003352)3.88177654
16protein complex biogenesis (GO:0070271)3.85294883
17synaptic vesicle exocytosis (GO:0016079)3.81086365
18neuron cell-cell adhesion (GO:0007158)3.77741174
19cilium movement (GO:0003341)3.68133687
20UTP biosynthetic process (GO:0006228)3.67761490
21axonemal dynein complex assembly (GO:0070286)3.67637497
22behavioral response to nicotine (GO:0035095)3.66234493
23mitochondrial respiratory chain complex assembly (GO:0033108)3.65171324
24epithelial cilium movement (GO:0003351)3.62754072
25vocalization behavior (GO:0071625)3.56533178
26protein localization to synapse (GO:0035418)3.56362414
27cullin deneddylation (GO:0010388)3.55128602
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.54685025
29NADH dehydrogenase complex assembly (GO:0010257)3.54685025
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54685025
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51606357
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.47450470
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38384515
34energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.35011663
35ATP hydrolysis coupled proton transport (GO:0015991)3.35011663
36cilium or flagellum-dependent cell motility (GO:0001539)3.33710467
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.29637543
38protein deneddylation (GO:0000338)3.27756043
39nucleoside diphosphate phosphorylation (GO:0006165)3.26378839
40negative regulation of microtubule polymerization (GO:0031115)3.21165407
41establishment of integrated proviral latency (GO:0075713)3.20958630
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18713634
43regulation of protein kinase A signaling (GO:0010738)3.18446494
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16382739
45ATP biosynthetic process (GO:0006754)3.14306031
46UTP metabolic process (GO:0046051)3.12388950
47establishment of mitochondrion localization (GO:0051654)3.10505120
48regulation of glutamate receptor signaling pathway (GO:1900449)3.09905052
49nucleobase catabolic process (GO:0046113)3.09709487
50glutamate secretion (GO:0014047)3.06449167
51regulation of synaptic vesicle exocytosis (GO:2000300)3.06094017
52hydrogen ion transmembrane transport (GO:1902600)3.04560706
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03720884
54intraciliary transport (GO:0042073)3.03671386
55CTP biosynthetic process (GO:0006241)3.03193201
56CTP metabolic process (GO:0046036)3.03193201
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01284004
58neuronal action potential propagation (GO:0019227)2.98387499
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.96856533
60deoxyribose phosphate biosynthetic process (GO:0046385)2.93956453
612-deoxyribonucleotide biosynthetic process (GO:0009265)2.93956453
62motile cilium assembly (GO:0044458)2.92606555
63acrosome reaction (GO:0007340)2.90304506
64calcium ion-dependent exocytosis (GO:0017156)2.89626928
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88862508
66postsynaptic membrane organization (GO:0001941)2.88706905
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87776195
68deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84424254
69DNA deamination (GO:0045006)2.81531961
70nucleoside triphosphate biosynthetic process (GO:0009142)2.81485848
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80735167
72nonmotile primary cilium assembly (GO:0035058)2.80208552
73GMP metabolic process (GO:0046037)2.79756735
74negative regulation of telomere maintenance (GO:0032205)2.78861062
75oxidative phosphorylation (GO:0006119)2.78556011
76positive regulation of synapse assembly (GO:0051965)2.78230460
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75370854
78protein targeting to mitochondrion (GO:0006626)2.74671744
79regulation of mitochondrial translation (GO:0070129)2.73920769
80proteasome assembly (GO:0043248)2.73666797
81regulation of synaptic vesicle transport (GO:1902803)2.73335604
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72928307
83cell proliferation in forebrain (GO:0021846)2.72484270
84retinal rod cell development (GO:0046548)2.71868161
85dopamine transport (GO:0015872)2.71550944
86synaptic vesicle maturation (GO:0016188)2.71478253
87establishment of protein localization to mitochondrion (GO:0072655)2.71190446
88neuron recognition (GO:0008038)2.71119103
89pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.70899274
90axoneme assembly (GO:0035082)2.70120237
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70031718
92regulation of microtubule-based movement (GO:0060632)2.69862629
93transferrin transport (GO:0033572)2.67550813
94positive regulation of synapse maturation (GO:0090129)2.67135339
95positive regulation of neurotransmitter secretion (GO:0001956)2.66988074
96L-serine metabolic process (GO:0006563)2.66352867
97regulation of oxidative phosphorylation (GO:0002082)2.66275639
98neuron-neuron synaptic transmission (GO:0007270)2.63771733
99regulation of glutamate secretion (GO:0014048)2.63544661
100establishment of melanosome localization (GO:0032401)2.62992459
101neurotransmitter secretion (GO:0007269)2.61919552
102pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60922259
103synaptic transmission, glutamatergic (GO:0035249)2.60130095
104proton transport (GO:0015992)2.60049718
105DNA damage response, detection of DNA damage (GO:0042769)2.59314900
106protein localization to mitochondrion (GO:0070585)2.58846160
107aldehyde catabolic process (GO:0046185)2.58470974
108protein insertion into membrane (GO:0051205)2.56430530
109histone arginine methylation (GO:0034969)2.56415712
110presynaptic membrane assembly (GO:0097105)2.56151765
111termination of RNA polymerase III transcription (GO:0006386)2.54999217
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.54999217
113axonal fasciculation (GO:0007413)2.54814829
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.54811744
115positive regulation of mitochondrial fission (GO:0090141)2.54472741
116resolution of meiotic recombination intermediates (GO:0000712)2.54315682
117ribosomal small subunit assembly (GO:0000028)2.54206287
118hydrogen transport (GO:0006818)2.53504768
119detection of calcium ion (GO:0005513)2.52506289
120substrate-independent telencephalic tangential migration (GO:0021826)2.52482006
121substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52482006
122respiratory chain complex IV assembly (GO:0008535)2.51926141
123protein neddylation (GO:0045116)2.51428665
124negative regulation of oligodendrocyte differentiation (GO:0048715)2.51267404
125peptidyl-arginine omega-N-methylation (GO:0035247)2.50398441
126melanosome transport (GO:0032402)2.48680570
127establishment of pigment granule localization (GO:0051905)2.48128659
128positive regulation of neurotransmitter transport (GO:0051590)2.47909636
129microtubule severing (GO:0051013)2.47620086
130short-term memory (GO:0007614)2.46337873
131protein-cofactor linkage (GO:0018065)2.46271776
132anterograde axon cargo transport (GO:0008089)2.45578964
133transmission of nerve impulse (GO:0019226)2.42235649
134melanosome organization (GO:0032438)2.41820222
135retinal ganglion cell axon guidance (GO:0031290)2.41727320
136peptidyl-histidine modification (GO:0018202)2.41520292
137tyrosine metabolic process (GO:0006570)2.40731667
138maturation of SSU-rRNA (GO:0030490)2.40512355
139growth hormone secretion (GO:0030252)2.39008146
140anterograde synaptic vesicle transport (GO:0048490)2.38853628
141dendritic spine morphogenesis (GO:0060997)2.38050579
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37042666
143ribonucleoprotein complex disassembly (GO:0032988)2.34326968
144pigment granule transport (GO:0051904)2.33791683
145intracellular protein transmembrane import (GO:0044743)2.33384192
146regulation of cellular respiration (GO:0043457)2.32817570
147somite development (GO:0061053)2.32595430
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.29498734
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.29498734
150melanosome localization (GO:0032400)2.29436672
151establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.28243991
152mitochondrion transport along microtubule (GO:0047497)2.28243991
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.28043420
154ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.27897655
155viral transcription (GO:0019083)2.27753343
156base-excision repair, AP site formation (GO:0006285)2.27624331
157mannosylation (GO:0097502)2.26146970
158sequestering of actin monomers (GO:0042989)2.25260061
159hippocampus development (GO:0021766)2.24725379
160protein polyglutamylation (GO:0018095)2.21402512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01722783
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02596150
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71125550
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60519636
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56912532
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49503143
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44560743
8GBX2_23144817_ChIP-Seq_PC3_Human2.41030945
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40131499
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39471439
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.38894982
12REST_21632747_ChIP-Seq_MESCs_Mouse2.27331682
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.24730134
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15153910
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.12607038
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10223897
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04736366
18TAF15_26573619_Chip-Seq_HEK293_Human2.01122157
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95253957
20* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92957469
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.92847297
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.89944213
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.89249427
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84721188
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78964011
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74382729
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73845833
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71490284
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70800821
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69123166
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66626293
32SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.65638802
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.64710099
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63107615
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62887733
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62401850
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58809267
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58380509
39ZNF274_21170338_ChIP-Seq_K562_Hela1.58162178
40VDR_22108803_ChIP-Seq_LS180_Human1.54924775
41IGF1R_20145208_ChIP-Seq_DFB_Human1.50524590
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48950692
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48227348
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41748716
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41567272
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41398061
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41397414
48ELK1_19687146_ChIP-ChIP_HELA_Human1.40608372
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36952367
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34703469
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34461567
52RNF2_27304074_Chip-Seq_NSC_Mouse1.33124331
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.31943397
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.31626664
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31306766
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.31049157
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.30880213
58FUS_26573619_Chip-Seq_HEK293_Human1.29894511
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29380003
60* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28916694
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28527743
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.27769950
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27681526
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27502777
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26480444
66TTF2_22483619_ChIP-Seq_HELA_Human1.26352837
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25944762
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.23584588
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23524525
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23251712
71VDR_23849224_ChIP-Seq_CD4+_Human1.23231594
72IRF1_19129219_ChIP-ChIP_H3396_Human1.22397664
73GABP_19822575_ChIP-Seq_HepG2_Human1.21514246
74XRN2_22483619_ChIP-Seq_HELA_Human1.20491799
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20323180
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18509021
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16960535
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16232656
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16107527
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16107527
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15290777
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14872064
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13063332
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13005485
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12054148
86DCP1A_22483619_ChIP-Seq_HELA_Human1.11535011
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08178647
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07137460
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06309672
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05036615
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03948058
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02504008
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02158157
94* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01876107
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.01849938
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01219577
97P300_19829295_ChIP-Seq_ESCs_Human1.00515870
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00322146
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99725754
100FOXP3_21729870_ChIP-Seq_TREG_Human0.98789025
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98309093
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97653839
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95660348
104FOXP1_21924763_ChIP-Seq_HESCs_Human0.94448308
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.94265010
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94057265
107EWS_26573619_Chip-Seq_HEK293_Human0.93358219
108JUN_21703547_ChIP-Seq_K562_Human0.90944622
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.89745192
110MYC_18940864_ChIP-ChIP_HL60_Human0.87674346
111SOX9_26525672_Chip-Seq_HEART_Mouse0.87627143
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.87607568
113NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87153118
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87026286
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86164337
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85681859
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85404820
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84531354
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84327418
120* SMAD4_21799915_ChIP-Seq_A2780_Human0.83894205
121KDM5A_27292631_Chip-Seq_BREAST_Human0.82323810
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82055941
123REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80890939
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79704686
125TP53_22573176_ChIP-Seq_HFKS_Human0.79132139
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76316208
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76316208
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.75857017
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75211901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.14883220
2MP0004859_abnormal_synaptic_plasticity3.82129284
3MP0000372_irregular_coat_pigmentation3.75044651
4MP0003136_yellow_coat_color3.19521149
5MP0006276_abnormal_autonomic_nervous3.01159567
6MP0003635_abnormal_synaptic_transmissio2.94672930
7MP0001968_abnormal_touch/_nociception2.91877282
8MP0005171_absent_coat_pigmentation2.80371482
9MP0002736_abnormal_nociception_after2.67455406
10MP0001529_abnormal_vocalization2.66528781
11MP0009745_abnormal_behavioral_response2.58579035
12MP0004270_analgesia2.56055462
13MP0002063_abnormal_learning/memory/cond2.48251594
14MP0005423_abnormal_somatic_nervous2.46710623
15MP0002064_seizures2.29885395
16MP0005410_abnormal_fertilization2.28116995
17MP0002734_abnormal_mechanical_nocicepti2.28000840
18MP0002572_abnormal_emotion/affect_behav2.26801891
19MP0009046_muscle_twitch2.25684752
20MP0001188_hyperpigmentation2.24575726
21MP0009379_abnormal_foot_pigmentation2.16643363
22MP0002735_abnormal_chemical_nociception2.12977572
23MP0003122_maternal_imprinting2.11441513
24MP0002272_abnormal_nervous_system2.07545858
25MP0001984_abnormal_olfaction2.03671861
26MP0008877_abnormal_DNA_methylation1.98209234
27MP0005645_abnormal_hypothalamus_physiol1.96360889
28MP0005408_hypopigmentation1.96274070
29MP0005075_abnormal_melanosome_morpholog1.93462124
30MP0002095_abnormal_skin_pigmentation1.89873122
31MP0002938_white_spotting1.88549571
32MP0002733_abnormal_thermal_nociception1.80049770
33MP0001501_abnormal_sleep_pattern1.77990990
34MP0001905_abnormal_dopamine_level1.77749595
35MP0002184_abnormal_innervation1.76193529
36MP0005646_abnormal_pituitary_gland1.76052458
37MP0001440_abnormal_grooming_behavior1.75634569
38MP0001970_abnormal_pain_threshold1.69880344
39MP0002067_abnormal_sensory_capabilities1.68285319
40MP0001486_abnormal_startle_reflex1.64414237
41MP0002557_abnormal_social/conspecific_i1.62923791
42MP0002638_abnormal_pupillary_reflex1.58934276
43MP0010030_abnormal_orbit_morphology1.57395346
44MP0001293_anophthalmia1.55008133
45MP0000778_abnormal_nervous_system1.54275346
46MP0002837_dystrophic_cardiac_calcinosis1.52816024
47MP0005394_taste/olfaction_phenotype1.50236523
48MP0005499_abnormal_olfactory_system1.50236523
49MP0001324_abnormal_eye_pigmentation1.47721647
50MP0004142_abnormal_muscle_tone1.46013152
51MP0004811_abnormal_neuron_physiology1.43784555
52MP0004924_abnormal_behavior1.43334630
53MP0005386_behavior/neurological_phenoty1.43334630
54MP0002876_abnormal_thyroid_physiology1.41075490
55MP0003787_abnormal_imprinting1.38940644
56MP0006292_abnormal_olfactory_placode1.37905938
57MP0002102_abnormal_ear_morphology1.34272806
58MP0003698_abnormal_male_reproductive1.33321815
59MP0008789_abnormal_olfactory_epithelium1.32013136
60MP0000631_abnormal_neuroendocrine_gland1.29580484
61MP0001986_abnormal_taste_sensitivity1.28828988
62MP0003879_abnormal_hair_cell1.26692600
63MP0005253_abnormal_eye_physiology1.24799394
64MP0002822_catalepsy1.22549519
65MP0000955_abnormal_spinal_cord1.22101667
66MP0003693_abnormal_embryo_hatching1.20785581
67MP0004133_heterotaxia1.19785406
68MP0005377_hearing/vestibular/ear_phenot1.19514040
69MP0003878_abnormal_ear_physiology1.19514040
70MP0006035_abnormal_mitochondrial_morpho1.17901164
71MP0002882_abnormal_neuron_morphology1.17201874
72MP0003121_genomic_imprinting1.13313240
73MP0002160_abnormal_reproductive_system1.11866123
74MP0002066_abnormal_motor_capabilities/c1.10140644
75MP0002090_abnormal_vision1.09698674
76MP0002653_abnormal_ependyma_morphology1.08602825
77MP0003186_abnormal_redox_activity1.08373172
78MP0001502_abnormal_circadian_rhythm1.07839229
79MP0000015_abnormal_ear_pigmentation1.06876099
80MP0002751_abnormal_autonomic_nervous1.06609506
81MP0006036_abnormal_mitochondrial_physio1.05955901
82MP0009780_abnormal_chondrocyte_physiolo1.04988210
83MP0001929_abnormal_gametogenesis1.04807839
84MP0002909_abnormal_adrenal_gland1.04198117
85MP0005195_abnormal_posterior_eye1.03710078
86MP0004742_abnormal_vestibular_system1.01775580
87MP0008569_lethality_at_weaning1.01060584
88MP0002152_abnormal_brain_morphology0.99706533
89MP0000751_myopathy0.98745883
90MP0003718_maternal_effect0.96593056
91MP0000371_diluted_coat_color0.95129291
92MP0004858_abnormal_nervous_system0.94952183
93MP0005391_vision/eye_phenotype0.94204822
94MP0008872_abnormal_physiological_respon0.94171113
95MP0000049_abnormal_middle_ear0.93255557
96MP0003123_paternal_imprinting0.93154752
97MP0004885_abnormal_endolymph0.89417000
98MP0002075_abnormal_coat/hair_pigmentati0.89406099
99MP0002752_abnormal_somatic_nervous0.89405857
100MP0003567_abnormal_fetal_cardiomyocyte0.89200575
101MP0001963_abnormal_hearing_physiology0.88788823
102MP0001186_pigmentation_phenotype0.88152867
103MP0008058_abnormal_DNA_repair0.85279109
104MP0000026_abnormal_inner_ear0.85220261
105MP0002229_neurodegeneration0.83973477
106MP0005174_abnormal_tail_pigmentation0.82868759
107MP0006072_abnormal_retinal_apoptosis0.82761024
108MP0010386_abnormal_urinary_bladder0.82055498
109MP0004147_increased_porphyrin_level0.81882813
110MP0000566_synostosis0.81293647
111MP0002210_abnormal_sex_determination0.81123162
112MP0002069_abnormal_eating/drinking_beha0.80607468
113MP0001664_abnormal_digestion0.80455675
114MP0002234_abnormal_pharynx_morphology0.80105330
115MP0000013_abnormal_adipose_tissue0.79734245
116MP0005409_darkened_coat_color0.78941214
117MP0003937_abnormal_limbs/digits/tail_de0.78270376
118MP0008995_early_reproductive_senescence0.78034398
119MP0003938_abnormal_ear_development0.77441430
120MP0003329_amyloid_beta_deposits0.75680048
121MP0005379_endocrine/exocrine_gland_phen0.74582769
122MP0000678_abnormal_parathyroid_gland0.74452850
123MP0002161_abnormal_fertility/fecundity0.74433247
124MP0003646_muscle_fatigue0.72465230
125MP0001485_abnormal_pinna_reflex0.72341816
126MP0004233_abnormal_muscle_weight0.71853706
127MP0004215_abnormal_myocardial_fiber0.71796665
128MP0003861_abnormal_nervous_system0.70851096
129MP0005551_abnormal_eye_electrophysiolog0.69578020
130MP0003315_abnormal_perineum_morphology0.69554371
131MP0008932_abnormal_embryonic_tissue0.69425220
132MP0002163_abnormal_gland_morphology0.69418686
133MP0005389_reproductive_system_phenotype0.65571020

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.92662360
2Abnormal mitochondria in muscle tissue (HP:0008316)4.63607566
3Focal motor seizures (HP:0011153)4.54478192
4Mitochondrial inheritance (HP:0001427)4.25531084
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.18444527
6Abnormal respiratory motile cilium physiology (HP:0012261)4.13788933
7Progressive macrocephaly (HP:0004481)4.12210982
8Abnormal respiratory motile cilium morphology (HP:0005938)4.09105775
9Abnormal respiratory epithelium morphology (HP:0012253)4.09105775
10Abnormal ciliary motility (HP:0012262)4.06187846
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.95413058
12Absent/shortened dynein arms (HP:0200106)3.95413058
13Myokymia (HP:0002411)3.84319268
14Acute encephalopathy (HP:0006846)3.75410706
15Hepatocellular necrosis (HP:0001404)3.71629389
16Increased CSF lactate (HP:0002490)3.61560861
17Medial flaring of the eyebrow (HP:0010747)3.54577037
18Rhinitis (HP:0012384)3.51711937
19Gait imbalance (HP:0002141)3.49037456
20Abnormality of the labia minora (HP:0012880)3.34570212
21Reticulocytopenia (HP:0001896)3.28113622
22Congenital primary aphakia (HP:0007707)3.25950111
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21407430
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21407430
25Epileptic encephalopathy (HP:0200134)3.20855196
26Nephrogenic diabetes insipidus (HP:0009806)3.15228724
27Visual hallucinations (HP:0002367)3.03535267
28Atonic seizures (HP:0010819)2.90257584
29Increased hepatocellular lipid droplets (HP:0006565)2.86553970
30Pancreatic fibrosis (HP:0100732)2.83974912
31Hepatic necrosis (HP:0002605)2.83943592
32Focal seizures (HP:0007359)2.73990024
33Poor suck (HP:0002033)2.71929723
34True hermaphroditism (HP:0010459)2.71777721
35Exercise intolerance (HP:0003546)2.70585075
36Colon cancer (HP:0003003)2.70498467
37Optic disc pallor (HP:0000543)2.67793911
38Lactic acidosis (HP:0003128)2.58892152
39Abnormality of midbrain morphology (HP:0002418)2.57931355
40Molar tooth sign on MRI (HP:0002419)2.57931355
41Limb dystonia (HP:0002451)2.55652518
42Iris hypopigmentation (HP:0007730)2.54928586
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.53888730
44Hypoplasia of the fovea (HP:0007750)2.53888730
45Febrile seizures (HP:0002373)2.47901100
46Increased intramyocellular lipid droplets (HP:0012240)2.47343974
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46422435
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41655289
49Increased serum lactate (HP:0002151)2.40895702
50Hyperventilation (HP:0002883)2.40588234
51Absence seizures (HP:0002121)2.40128245
52Lipid accumulation in hepatocytes (HP:0006561)2.38540249
53Abnormal hair whorl (HP:0010721)2.38241449
54Delusions (HP:0000746)2.37034404
55Abnormality of glycolysis (HP:0004366)2.36556055
56Increased serum pyruvate (HP:0003542)2.36556055
57Vaginal atresia (HP:0000148)2.35069472
58Type II lissencephaly (HP:0007260)2.34825709
59Aplasia/Hypoplasia of the macula (HP:0008059)2.32924834
60Genital tract atresia (HP:0001827)2.32837539
61Leukodystrophy (HP:0002415)2.32619389
62Respiratory failure (HP:0002878)2.31686834
63Abnormality of the fovea (HP:0000493)2.29526830
64Anophthalmia (HP:0000528)2.29431063
65Polyphagia (HP:0002591)2.29200711
66Chronic bronchitis (HP:0004469)2.27051623
67Pheochromocytoma (HP:0002666)2.26493174
68Renal Fanconi syndrome (HP:0001994)2.26054474
69Neuroendocrine neoplasm (HP:0100634)2.24402401
70Unsteady gait (HP:0002317)2.24254425
71Nephronophthisis (HP:0000090)2.24175736
72Pancreatic cysts (HP:0001737)2.23507626
73Infertility (HP:0000789)2.21015032
74Emotional lability (HP:0000712)2.19495299
75Poor coordination (HP:0002370)2.19478583
76Generalized hypopigmentation (HP:0007513)2.17509567
77Aplasia/Hypoplasia affecting the retina (HP:0008061)2.16615964
78Hyperglycinemia (HP:0002154)2.15470795
79Amblyopia (HP:0000646)2.15377419
80Hypothermia (HP:0002045)2.13320093
81Retinal dysplasia (HP:0007973)2.13193688
823-Methylglutaconic aciduria (HP:0003535)2.10322609
83Dialeptic seizures (HP:0011146)2.09982830
84Cerebral edema (HP:0002181)2.08929728
85Inability to walk (HP:0002540)2.08086006
86Specific learning disability (HP:0001328)2.07408376
87Lissencephaly (HP:0001339)2.05624656
88Adrenal hypoplasia (HP:0000835)2.03045837
89Anxiety (HP:0000739)2.00955167
90Abnormality of the corticospinal tract (HP:0002492)1.99536241
91Ocular albinism (HP:0001107)1.99310339
92Anencephaly (HP:0002323)1.98989280
93Increased muscle lipid content (HP:0009058)1.98333322
94Abnormality of the anterior horn cell (HP:0006802)1.97700755
95Degeneration of anterior horn cells (HP:0002398)1.97700755
96Congenital stationary night blindness (HP:0007642)1.94840147
97Pendular nystagmus (HP:0012043)1.94113900
98Cerebellar dysplasia (HP:0007033)1.93360675
99Septo-optic dysplasia (HP:0100842)1.92586245
100Oligodactyly (hands) (HP:0001180)1.91967880
101Progressive cerebellar ataxia (HP:0002073)1.91422098
102Intestinal atresia (HP:0011100)1.90951813
103Abnormal eating behavior (HP:0100738)1.90596635
104Hepatoblastoma (HP:0002884)1.90559340
105Broad-based gait (HP:0002136)1.89045662
106Rib fusion (HP:0000902)1.89010602
107Optic nerve hypoplasia (HP:0000609)1.88140745
108Aplasia/Hypoplasia of the lens (HP:0008063)1.87543085
109Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87486968
110Abnormality of cells of the erythroid lineage (HP:0012130)1.87210156
111Progressive inability to walk (HP:0002505)1.87175848
112Failure to thrive in infancy (HP:0001531)1.86235320
113Generalized tonic-clonic seizures (HP:0002069)1.84023937
114Exertional dyspnea (HP:0002875)1.83170682
115Aganglionic megacolon (HP:0002251)1.81914304
116Respiratory difficulties (HP:0002880)1.81371382
117Hypoplasia of the brainstem (HP:0002365)1.81213788
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81213788
119Sclerocornea (HP:0000647)1.80998872
120Oligomenorrhea (HP:0000876)1.78569819
121Abnormal number of erythroid precursors (HP:0012131)1.77759569
122Patchy hypopigmentation of hair (HP:0011365)1.74893303
123CNS hypomyelination (HP:0003429)1.74523121
124White forelock (HP:0002211)1.74324039
125Growth hormone deficiency (HP:0000824)1.73802757
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.73337950
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73337950
128Astigmatism (HP:0000483)1.73193892
129Protruding tongue (HP:0010808)1.72704040
130Abnormality of alanine metabolism (HP:0010916)1.72292921
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72292921
132Postaxial hand polydactyly (HP:0001162)1.71699990
133Esotropia (HP:0000565)1.70843976
134Occipital encephalocele (HP:0002085)1.70826820
135Cortical dysplasia (HP:0002539)1.70769518
136Sleep apnea (HP:0010535)1.70696397
137Spastic tetraplegia (HP:0002510)1.70638204
138Abnormal number of incisors (HP:0011064)1.70458164
139Bronchiectasis (HP:0002110)1.70243062
140Neoplasm of the adrenal cortex (HP:0100641)1.69889404
141Narrow forehead (HP:0000341)1.69229606
142Cerebral hypomyelination (HP:0006808)1.68763521
143Preaxial hand polydactyly (HP:0001177)1.68308450
144Broad foot (HP:0001769)1.65067610
145Hyperalaninemia (HP:0003348)1.64628898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.83254651
2CASK3.60088882
3STK162.93520160
4MAP4K22.86860957
5MAP2K72.83781444
6NTRK32.77286520
7TRIM282.54524331
8PNCK2.46392859
9MARK12.44261749
10MINK12.39537481
11MAP3K42.34244058
12ARAF2.34203004
13NME12.26089557
14CDK192.25875132
15CCNB12.21619792
16BUB12.11986987
17DAPK12.10972605
18EPHA42.10067857
19VRK22.01965452
20BCKDK1.94588617
21MAP3K91.94383957
22EPHB21.93351650
23SIK31.91037484
24VRK11.85929913
25PINK11.80372295
26CSNK1A1L1.79820304
27PDK41.79535987
28PDK31.79535987
29CSNK1G11.77358488
30BRAF1.73533360
31GRK51.71079529
32PLK21.66446152
33MAPK131.63909114
34WEE11.47874878
35NTRK21.47660564
36DAPK21.44883834
37UHMK11.29838812
38DYRK31.29685482
39MAP2K41.28577075
40ZAK1.24580268
41TNIK1.23775251
42TESK11.22490707
43TSSK61.19346662
44MUSK1.15927839
45KSR11.10992563
46DYRK21.08654236
47PRKCG1.07376580
48SRPK11.06270225
49PTK2B1.03813793
50NUAK11.00756588
51PRKD30.96621291
52BRSK10.96224440
53AKT30.96073724
54CDC70.95354255
55CDK180.94719052
56CDK80.92117257
57BCR0.90892924
58GRK70.90106641
59CDK50.85326287
60CDK140.85272239
61RIPK40.84853310
62TTK0.83670243
63ADRBK20.83420951
64CDK150.83347063
65WNK30.83258587
66SIK20.82531114
67MYLK0.81203524
68EIF2AK10.79556088
69ATR0.78927186
70PLK40.77801733
71BMPR1B0.77044060
72CDK11A0.76904209
73PLK30.75997914
74PBK0.75982443
75AURKA0.73532425
76MARK30.72305740
77PRPF4B0.72128278
78NEK20.71505847
79BMPR20.71333292
80CAMKK20.69167623
81CAMK2A0.67360481
82RAF10.66143941
83ADRBK10.65766531
84MAPK150.63885759
85PAK30.63622021
86TYRO30.62734221
87TNK20.60617547
88PDK20.60463392
89RPS6KA40.59043592
90PIM20.57311494
91GRK10.56064804
92OXSR10.55833413
93ABL20.55713496
94CAMK2B0.55163090
95DYRK1A0.54882263
96MAPKAPK50.54737114
97EIF2AK30.53256132
98CSNK1A10.53115186
99TLK10.52854666
100CSNK1E0.52315735
101AURKB0.48856356
102PRKACA0.48249425
103DAPK30.47670817
104MAP3K110.46617220
105CSNK2A10.46467921
106CAMK10.46019238
107RPS6KA50.45756300
108ERBB30.45511803
109PRKCE0.44376380
110PRKCZ0.43980778
111ATM0.43883172
112PKN10.43461172
113MKNK10.42760060
114PLK10.42495826
115PAK60.42372754
116DYRK1B0.42231056
117NEK10.39239115
118PHKG20.38810820
119PHKG10.38810820
120CSNK1G20.37286040
121CAMKK10.37275905
122BRSK20.36889938
123WNK40.36823207
124KSR20.36228187
125NME20.35360496
126CSNK1G30.35094801
127LIMK10.34968267
128ILK0.34887382
129PRKCI0.33838954
130CHEK20.33776782
131MAP3K60.33438633
132NTRK10.33410911
133FES0.30645171
134CSNK2A20.30554265
135TESK20.30350168

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.42045837
2Parkinsons disease_Homo sapiens_hsa050123.90083494
3Huntingtons disease_Homo sapiens_hsa050163.14588903
4Synaptic vesicle cycle_Homo sapiens_hsa047213.09835672
5Nicotine addiction_Homo sapiens_hsa050333.03688121
6Alzheimers disease_Homo sapiens_hsa050102.92862723
7Proteasome_Homo sapiens_hsa030502.79251269
8Collecting duct acid secretion_Homo sapiens_hsa049662.69496960
9Ribosome_Homo sapiens_hsa030102.26732908
10Cardiac muscle contraction_Homo sapiens_hsa042602.11645541
11RNA polymerase_Homo sapiens_hsa030202.00838057
12Olfactory transduction_Homo sapiens_hsa047401.97551654
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95256218
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88870146
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86660925
16Amphetamine addiction_Homo sapiens_hsa050311.85462538
17Circadian entrainment_Homo sapiens_hsa047131.74720137
18Vibrio cholerae infection_Homo sapiens_hsa051101.73168498
19Long-term potentiation_Homo sapiens_hsa047201.64261903
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64121433
21GABAergic synapse_Homo sapiens_hsa047271.63035761
22Dopaminergic synapse_Homo sapiens_hsa047281.61023643
23Morphine addiction_Homo sapiens_hsa050321.60087293
24DNA replication_Homo sapiens_hsa030301.59029406
25Steroid biosynthesis_Homo sapiens_hsa001001.57637365
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54428319
27Taste transduction_Homo sapiens_hsa047421.49985076
28Pyrimidine metabolism_Homo sapiens_hsa002401.49333398
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47531893
30Protein export_Homo sapiens_hsa030601.47036591
31Glutamatergic synapse_Homo sapiens_hsa047241.38551080
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35674199
33Serotonergic synapse_Homo sapiens_hsa047261.32314158
34Spliceosome_Homo sapiens_hsa030401.28874211
35Insulin secretion_Homo sapiens_hsa049111.28521062
36Mismatch repair_Homo sapiens_hsa034301.26455927
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25917634
38Fatty acid elongation_Homo sapiens_hsa000621.24567815
39Purine metabolism_Homo sapiens_hsa002301.20316281
40Oocyte meiosis_Homo sapiens_hsa041141.15784672
41Biosynthesis of amino acids_Homo sapiens_hsa012301.14862821
42Tyrosine metabolism_Homo sapiens_hsa003501.12069742
43Calcium signaling pathway_Homo sapiens_hsa040201.10342475
44Nucleotide excision repair_Homo sapiens_hsa034201.10177575
45Butanoate metabolism_Homo sapiens_hsa006501.08541936
46Phototransduction_Homo sapiens_hsa047441.08520003
47Cocaine addiction_Homo sapiens_hsa050301.07402931
48Pyruvate metabolism_Homo sapiens_hsa006201.07027979
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06635230
50Propanoate metabolism_Homo sapiens_hsa006401.06428466
51Salivary secretion_Homo sapiens_hsa049701.05999984
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05245666
53Base excision repair_Homo sapiens_hsa034101.03834797
54Renin secretion_Homo sapiens_hsa049240.99142008
55Homologous recombination_Homo sapiens_hsa034400.98055250
56Cholinergic synapse_Homo sapiens_hsa047250.97008193
57Long-term depression_Homo sapiens_hsa047300.94902766
58Basal transcription factors_Homo sapiens_hsa030220.93790918
59Basal cell carcinoma_Homo sapiens_hsa052170.92487584
60Peroxisome_Homo sapiens_hsa041460.91033297
61RNA transport_Homo sapiens_hsa030130.90911887
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90214821
63Alcoholism_Homo sapiens_hsa050340.90046117
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89324313
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87238819
66Vitamin B6 metabolism_Homo sapiens_hsa007500.84564106
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84284641
68Arginine and proline metabolism_Homo sapiens_hsa003300.83799161
69Gap junction_Homo sapiens_hsa045400.83395454
70Glutathione metabolism_Homo sapiens_hsa004800.81387360
71Gastric acid secretion_Homo sapiens_hsa049710.81312628
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79834741
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77110570
74Oxytocin signaling pathway_Homo sapiens_hsa049210.76987132
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73534562
76RNA degradation_Homo sapiens_hsa030180.73347232
77Folate biosynthesis_Homo sapiens_hsa007900.70801521
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70489835
79N-Glycan biosynthesis_Homo sapiens_hsa005100.67173831
80One carbon pool by folate_Homo sapiens_hsa006700.61762625
81Fanconi anemia pathway_Homo sapiens_hsa034600.60810596
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60713409
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60515904
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56885398
85Hippo signaling pathway_Homo sapiens_hsa043900.56686839
86Sulfur metabolism_Homo sapiens_hsa009200.55929738
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55889878
88beta-Alanine metabolism_Homo sapiens_hsa004100.55471240
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54733788
90Selenocompound metabolism_Homo sapiens_hsa004500.54688888
91Melanogenesis_Homo sapiens_hsa049160.52889497
92Linoleic acid metabolism_Homo sapiens_hsa005910.51798319
93GnRH signaling pathway_Homo sapiens_hsa049120.50822978
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.49547543
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49398910
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48897103
97Glucagon signaling pathway_Homo sapiens_hsa049220.48788412
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.47352082
99mRNA surveillance pathway_Homo sapiens_hsa030150.45909447
100Ether lipid metabolism_Homo sapiens_hsa005650.45656413
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43648727
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41996664
103Metabolic pathways_Homo sapiens_hsa011000.41746925
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.41587119
105cAMP signaling pathway_Homo sapiens_hsa040240.41570044
106Phagosome_Homo sapiens_hsa041450.41371593
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40811641
108Fructose and mannose metabolism_Homo sapiens_hsa000510.39352454
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38174726
110Estrogen signaling pathway_Homo sapiens_hsa049150.38163229
111Rheumatoid arthritis_Homo sapiens_hsa053230.38137151
112Cell cycle_Homo sapiens_hsa041100.36961866
113Type I diabetes mellitus_Homo sapiens_hsa049400.35950904
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35795938
115Axon guidance_Homo sapiens_hsa043600.35612266
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34992658
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34671740
118Non-homologous end-joining_Homo sapiens_hsa034500.34464671
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33836225
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.33577353
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33065122
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27679225
123Carbon metabolism_Homo sapiens_hsa012000.26585437
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25465260
125Epstein-Barr virus infection_Homo sapiens_hsa051690.24468898
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22761324
127Glioma_Homo sapiens_hsa052140.22370141
128Regulation of autophagy_Homo sapiens_hsa041400.22082681
129Wnt signaling pathway_Homo sapiens_hsa043100.21457754
130Hedgehog signaling pathway_Homo sapiens_hsa043400.20070956
131Sulfur relay system_Homo sapiens_hsa041220.16203958
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16108549

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