CHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.24054751
2nuclear pore organization (GO:0006999)5.92501836
3pore complex assembly (GO:0046931)4.82857915
4mitotic sister chromatid cohesion (GO:0007064)4.61530414
5protein localization to kinetochore (GO:0034501)4.22407541
6DNA unwinding involved in DNA replication (GO:0006268)4.22126923
7regulation of RNA export from nucleus (GO:0046831)4.15077059
8mitotic nuclear envelope disassembly (GO:0007077)3.99523584
9histone H3-K4 trimethylation (GO:0080182)3.85619198
10mitotic metaphase plate congression (GO:0007080)3.75331661
11pre-miRNA processing (GO:0031054)3.75272196
12nuclear envelope disassembly (GO:0051081)3.70728389
13membrane disassembly (GO:0030397)3.70728389
14regulation of histone H3-K9 methylation (GO:0051570)3.68542789
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.65683558
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.65683558
17regulation of translation, ncRNA-mediated (GO:0045974)3.65683558
18peptidyl-lysine trimethylation (GO:0018023)3.62505370
19regulation of spindle organization (GO:0090224)3.59136693
20mitotic chromosome condensation (GO:0007076)3.58404762
21kinetochore organization (GO:0051383)3.54021166
22protein localization to chromosome, centromeric region (GO:0071459)3.52985035
23positive regulation of chromosome segregation (GO:0051984)3.48036739
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45562077
25protein K11-linked deubiquitination (GO:0035871)3.42530481
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41152300
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41152300
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.41152300
29regulation of mitotic spindle organization (GO:0060236)3.40645963
30histone H3-K9 methylation (GO:0051567)3.40604220
31negative regulation of histone methylation (GO:0031061)3.40141345
32metaphase plate congression (GO:0051310)3.36982115
33sister chromatid segregation (GO:0000819)3.34511509
34ribosome assembly (GO:0042255)3.34400433
35* DNA duplex unwinding (GO:0032508)3.34113853
36* DNA geometric change (GO:0032392)3.33746324
37centriole replication (GO:0007099)3.30828820
38DNA replication-dependent nucleosome organization (GO:0034723)3.29490748
39DNA replication-dependent nucleosome assembly (GO:0006335)3.29490748
40histone H3-K9 modification (GO:0061647)3.26481575
41regulation of centrosome duplication (GO:0010824)3.25579057
42IMP biosynthetic process (GO:0006188)3.25381228
43phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.24378049
44regulation of sister chromatid cohesion (GO:0007063)3.24162969
45cytoplasmic mRNA processing body assembly (GO:0033962)3.20412130
46replication fork processing (GO:0031297)3.20294945
47folic acid-containing compound biosynthetic process (GO:0009396)3.19887023
48neural tube formation (GO:0001841)3.19679028
49hepatocyte apoptotic process (GO:0097284)3.19172140
50regulation of nucleobase-containing compound transport (GO:0032239)3.16813345
51nucleobase biosynthetic process (GO:0046112)3.14868070
52DNA replication initiation (GO:0006270)3.14585829
53mitotic sister chromatid segregation (GO:0000070)3.14246484
54non-recombinational repair (GO:0000726)3.09503667
55double-strand break repair via nonhomologous end joining (GO:0006303)3.09503667
56chromatin assembly (GO:0031497)3.06734020
57regulation of helicase activity (GO:0051095)3.06522081
58regulation of posttranscriptional gene silencing (GO:0060147)3.04806289
59regulation of gene silencing by miRNA (GO:0060964)3.04806289
60regulation of gene silencing by RNA (GO:0060966)3.04806289
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03623722
62mitotic G2/M transition checkpoint (GO:0044818)3.02475851
63N-terminal protein amino acid acetylation (GO:0006474)3.02111137
64V(D)J recombination (GO:0033151)3.02055364
65monoubiquitinated protein deubiquitination (GO:0035520)3.01477177
66histone H3-K4 methylation (GO:0051568)2.98631233
67chromatin remodeling at centromere (GO:0031055)2.97790526
68dosage compensation (GO:0007549)2.97657621
69DNA replication-independent nucleosome organization (GO:0034724)2.96988522
70DNA replication-independent nucleosome assembly (GO:0006336)2.96988522
71purine nucleobase biosynthetic process (GO:0009113)2.96494418
72DNA replication checkpoint (GO:0000076)2.95039709
73CENP-A containing nucleosome assembly (GO:0034080)2.94862381
74meiotic chromosome segregation (GO:0045132)2.94371308
75peptidyl-lysine methylation (GO:0018022)2.92354868
76histone H2A monoubiquitination (GO:0035518)2.92062852
77heterochromatin organization (GO:0070828)2.92058468
78establishment of chromosome localization (GO:0051303)2.91535050
79chromatin assembly or disassembly (GO:0006333)2.90565963
80regulation of DNA endoreduplication (GO:0032875)2.89224187
81alternative mRNA splicing, via spliceosome (GO:0000380)2.89189564
82IMP metabolic process (GO:0046040)2.89105113
83nuclear envelope organization (GO:0006998)2.87863283
84ncRNA catabolic process (GO:0034661)2.87003652
85kinetochore assembly (GO:0051382)2.85578931
86rRNA catabolic process (GO:0016075)2.85376237
87maturation of SSU-rRNA (GO:0030490)2.85223142
88DNA topological change (GO:0006265)2.84838695
89histone H3-K36 demethylation (GO:0070544)2.83665768
90microtubule anchoring (GO:0034453)2.83162007
91negative regulation of DNA recombination (GO:0045910)2.82653399
92protein localization to chromosome (GO:0034502)2.81027090
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80610610
94regulation of fibroblast apoptotic process (GO:2000269)2.78419417
95regulation of centrosome cycle (GO:0046605)2.77717594
96formation of translation preinitiation complex (GO:0001731)2.77526071
97DNA strand elongation involved in DNA replication (GO:0006271)2.76822154
98attachment of spindle microtubules to kinetochore (GO:0008608)2.76355465
99* DNA conformation change (GO:0071103)2.76303332
100telomere maintenance via recombination (GO:0000722)2.76114235
101positive regulation of DNA-templated transcription, initiation (GO:2000144)2.75678302
102double-strand break repair via homologous recombination (GO:0000724)2.74718723
103regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73699963
104positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73699963
105mRNA splice site selection (GO:0006376)2.73401420
106interkinetic nuclear migration (GO:0022027)2.73332330
107mRNA transport (GO:0051028)2.73293356
108establishment of protein localization to Golgi (GO:0072600)2.72984858
109recombinational repair (GO:0000725)2.72002599
110regulation of chromosome segregation (GO:0051983)2.71376077
111protein K48-linked deubiquitination (GO:0071108)2.71163272
112spindle checkpoint (GO:0031577)2.71009492
113positive regulation of mRNA catabolic process (GO:0061014)2.70807266
114histone lysine methylation (GO:0034968)2.70789390
115negative regulation of DNA repair (GO:0045738)2.70259185
116ATP-dependent chromatin remodeling (GO:0043044)2.69122732
117histone mRNA catabolic process (GO:0071044)2.68775448
118RNA stabilization (GO:0043489)2.68406608
119mRNA stabilization (GO:0048255)2.68406608
120mitotic recombination (GO:0006312)2.67573623
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67494592
122sister chromatid cohesion (GO:0007062)2.67216788
123regulation of mitotic sister chromatid separation (GO:0010965)2.67026445
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66315674
125DNA strand elongation (GO:0022616)2.64415431
126positive regulation of histone H3-K4 methylation (GO:0051571)2.64103032
127regulation of centriole replication (GO:0046599)2.63992265
128positive regulation of mRNA metabolic process (GO:1903313)2.62847692
129positive regulation of mRNA processing (GO:0050685)2.62846846
130regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62163759
131regulation of mitotic spindle checkpoint (GO:1903504)2.62163759
132histone exchange (GO:0043486)2.61924854
133positive regulation of histone methylation (GO:0031062)2.61540069
134nucleus organization (GO:0006997)2.61220882
135regulation of chromatin silencing (GO:0031935)2.61012136
136regulation of telomere maintenance via telomerase (GO:0032210)2.60758804
137negative regulation of mRNA metabolic process (GO:1903312)2.60509064
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60191568
139negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60057221
140protein K63-linked deubiquitination (GO:0070536)2.59977752
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.57269553
142NLS-bearing protein import into nucleus (GO:0006607)2.54353652
143mitotic spindle checkpoint (GO:0071174)2.52863069
144ribosome biogenesis (GO:0042254)2.51787525
145RNA transport (GO:0050658)2.51719173
146establishment of RNA localization (GO:0051236)2.51719173
147nucleic acid transport (GO:0050657)2.51719173
148negative regulation of RNA splicing (GO:0033119)2.50947408
149chromosome segregation (GO:0007059)2.50597251
150spindle assembly checkpoint (GO:0071173)2.50436310
151regulation of mitotic sister chromatid segregation (GO:0033047)2.50285412
152regulation of sister chromatid segregation (GO:0033045)2.50285412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.94175741
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.96107695
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12910209
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.68799602
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.36348039
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19929905
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79580243
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.74992480
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48741886
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42276798
11AR_21909140_ChIP-Seq_LNCAP_Human2.37581848
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25439341
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.19435270
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15959248
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15283840
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11850158
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.11614215
18MYC_22102868_ChIP-Seq_BL_Human2.11346366
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10949970
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00425380
21EWS_26573619_Chip-Seq_HEK293_Human1.98924089
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98191546
23* FUS_26573619_Chip-Seq_HEK293_Human1.88066518
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85926489
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.81000704
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.78185415
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74566512
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.69931950
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65868379
30XRN2_22483619_ChIP-Seq_HELA_Human1.65686526
31VDR_23849224_ChIP-Seq_CD4+_Human1.62607938
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61950531
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61274954
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60213511
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58287994
36* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57669564
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56375625
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49551846
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47836478
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44927115
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44717284
42FOXP3_21729870_ChIP-Seq_TREG_Human1.42035942
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41696159
44* KDM5A_27292631_Chip-Seq_BREAST_Human1.38734582
45ZNF274_21170338_ChIP-Seq_K562_Hela1.34907084
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.34837685
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33435317
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32297527
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32296773
50RUNX_20019798_ChIP-Seq_JUKART_Human1.32051087
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32032256
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.31429770
53CIITA_25753668_ChIP-Seq_RAJI_Human1.28941475
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26217470
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26030382
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26030382
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26030382
58ER_23166858_ChIP-Seq_MCF-7_Human1.26010436
59TTF2_22483619_ChIP-Seq_HELA_Human1.24667160
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24564521
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22970509
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21230720
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19600658
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19467811
65* TAF15_26573619_Chip-Seq_HEK293_Human1.18607661
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.17943865
67VDR_22108803_ChIP-Seq_LS180_Human1.17221072
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16500770
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15873398
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14544522
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14462158
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14318108
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14318108
74* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14028244
75IRF1_19129219_ChIP-ChIP_H3396_Human1.13764551
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.13580929
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13494317
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.13432498
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12372138
80IGF1R_20145208_ChIP-Seq_DFB_Human1.12223259
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12051415
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10187640
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09710164
84* MYB_26560356_Chip-Seq_TH1_Human1.09477354
85TFEB_21752829_ChIP-Seq_HELA_Human1.09399950
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09217321
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07949837
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07913756
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07747435
90* P300_19829295_ChIP-Seq_ESCs_Human1.06684071
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05856795
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05075080
93DCP1A_22483619_ChIP-Seq_HELA_Human1.04177050
94MYB_26560356_Chip-Seq_TH2_Human1.04144435
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04143806
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02522285
97MYC_18940864_ChIP-ChIP_HL60_Human1.02469262
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01581145
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99970992
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99735757
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99537862
102ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99402257
103STAT3_23295773_ChIP-Seq_U87_Human0.99267639
104GATA3_26560356_Chip-Seq_TH2_Human0.99040017
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98665672
106STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98530217
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97805743
108CBP_20019798_ChIP-Seq_JUKART_Human0.97805743
109* GABP_19822575_ChIP-Seq_HepG2_Human0.97215462
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95162613
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95139903
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94515546
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94317521
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94249211
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.94205847
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94171270
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93188711
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92667725
119GATA3_27048872_Chip-Seq_THYMUS_Human0.91781177
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91709823
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91547425
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91228215
123* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90993384
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.90105593
125* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89883517
126VDR_21846776_ChIP-Seq_THP-1_Human0.89851949
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89786478
128* CHD1_26751641_Chip-Seq_LNCaP_Human0.89140647
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87860124
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87788767
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87749913
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87601944
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87554217
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87185831
135* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86903110
136SCL_19346495_ChIP-Seq_HPC-7_Human0.86864275
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86733126
138SPI1_23547873_ChIP-Seq_NB4_Human0.86691456
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.86592885
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85967791
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85871252
142MAF_26560356_Chip-Seq_TH1_Human0.84901377
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84800237
144SALL4_22934838_ChIP-ChIP_CD34+_Human0.84642767
145* UTX_26944678_Chip-Seq_JUKART_Human0.84350875
146GATA1_22025678_ChIP-Seq_K562_Human0.84099985
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83613816
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.83138406
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.83012463
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82980999
151TCF7_22412390_ChIP-Seq_EML_Mouse0.82635920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.92683627
2MP0010094_abnormal_chromosome_stability3.43808729
3MP0003693_abnormal_embryo_hatching3.36816734
4MP0004957_abnormal_blastocyst_morpholog3.16317732
5MP0003077_abnormal_cell_cycle3.14420774
6MP0003111_abnormal_nucleus_morphology3.05291181
7MP0010352_gastrointestinal_tract_polyps2.99151138
8MP0003787_abnormal_imprinting2.66453401
9MP0010307_abnormal_tumor_latency2.35556471
10MP0008007_abnormal_cellular_replicative2.30494812
11MP0002396_abnormal_hematopoietic_system2.21761128
12MP0008058_abnormal_DNA_repair2.12759468
13MP0001730_embryonic_growth_arrest2.06856207
14MP0000350_abnormal_cell_proliferation2.06575965
15MP0005076_abnormal_cell_differentiation2.00848525
16MP0005380_embryogenesis_phenotype1.81048762
17MP0001672_abnormal_embryogenesis/_devel1.81048762
18MP0004808_abnormal_hematopoietic_stem1.79197846
19MP0009697_abnormal_copulation1.76158344
20MP0006292_abnormal_olfactory_placode1.74845692
21MP0003890_abnormal_embryonic-extraembry1.71564724
22MP0003984_embryonic_growth_retardation1.71383239
23MP0008932_abnormal_embryonic_tissue1.69871679
24MP0002088_abnormal_embryonic_growth/wei1.69691920
25MP0004197_abnormal_fetal_growth/weight/1.68504003
26MP0003705_abnormal_hypodermis_morpholog1.65896936
27MP0003123_paternal_imprinting1.65521924
28MP0002086_abnormal_extraembryonic_tissu1.63954678
29MP0002084_abnormal_developmental_patter1.60513636
30MP0001697_abnormal_embryo_size1.59527138
31MP0001293_anophthalmia1.50371499
32MP0003763_abnormal_thymus_physiology1.49320236
33MP0002085_abnormal_embryonic_tissue1.48196072
34MP0003121_genomic_imprinting1.45967392
35MP0008877_abnormal_DNA_methylation1.45537753
36MP0008995_early_reproductive_senescence1.45320792
37MP0009053_abnormal_anal_canal1.44029867
38MP0003567_abnormal_fetal_cardiomyocyte1.32805547
39MP0002166_altered_tumor_susceptibility1.31407768
40MP0002080_prenatal_lethality1.30360560
41MP0000537_abnormal_urethra_morphology1.30310419
42MP0000703_abnormal_thymus_morphology1.29010764
43MP0003221_abnormal_cardiomyocyte_apopto1.25811254
44MP0002006_tumorigenesis1.25622178
45MP0000490_abnormal_crypts_of1.24827805
46MP0003786_premature_aging1.24504574
47MP0003566_abnormal_cell_adhesion1.23056892
48MP0003656_abnormal_erythrocyte_physiolo1.22940637
49MP0001545_abnormal_hematopoietic_system1.20847521
50MP0005397_hematopoietic_system_phenotyp1.20847521
51MP0002398_abnormal_bone_marrow1.19117398
52MP0003937_abnormal_limbs/digits/tail_de1.18057330
53MP0002019_abnormal_tumor_incidence1.15959884
54MP0001929_abnormal_gametogenesis1.14582150
55MP0010234_abnormal_vibrissa_follicle1.14141764
56MP0009333_abnormal_splenocyte_physiolog1.11419871
57MP0001915_intracranial_hemorrhage1.11391696
58MP0002092_abnormal_eye_morphology1.09100714
59MP0010030_abnormal_orbit_morphology1.07869357
60MP0000313_abnormal_cell_death1.07693932
61MP0000733_abnormal_muscle_development1.07606582
62MP0005310_abnormal_salivary_gland1.07600303
63MP0005023_abnormal_wound_healing1.07508246
64MP0008961_abnormal_basal_metabolism1.07213657
65MP0001800_abnormal_humoral_immune1.06770912
66MP0002722_abnormal_immune_system1.05424568
67MP0003941_abnormal_skin_development1.04903306
68MP0009278_abnormal_bone_marrow1.03845860
69MP0005174_abnormal_tail_pigmentation1.03170348
70MP0001835_abnormal_antigen_presentation1.01086654
71MP0000689_abnormal_spleen_morphology1.00395042
72MP0003950_abnormal_plasma_membrane0.96807656
73MP0003943_abnormal_hepatobiliary_system0.95914637
74MP0009703_decreased_birth_body0.95669933
75MP0002210_abnormal_sex_determination0.95336654
76MP0003724_increased_susceptibility_to0.94173251
77MP0000015_abnormal_ear_pigmentation0.93995657
78MP0000383_abnormal_hair_follicle0.93443792
79MP0000432_abnormal_head_morphology0.93158873
80MP0004381_abnormal_hair_follicle0.92649949
81MP0010678_abnormal_skin_adnexa0.91946622
82MP0002697_abnormal_eye_size0.90118159
83MP0004264_abnormal_extraembryonic_tissu0.89089644
84MP0001145_abnormal_male_reproductive0.88349327
85MP0000428_abnormal_craniofacial_morphol0.87712776
86MP0009672_abnormal_birth_weight0.87520657
87MP0001286_abnormal_eye_development0.87381348
88MP0005075_abnormal_melanosome_morpholog0.87371883
89MP0001119_abnormal_female_reproductive0.86918147
90MP0000569_abnormal_digit_pigmentation0.86758085
91MP0002009_preneoplasia0.86630678
92MP0000716_abnormal_immune_system0.85928142
93MP0002925_abnormal_cardiovascular_devel0.85912361
94MP0002452_abnormal_antigen_presenting0.85858053
95MP0003448_altered_tumor_morphology0.85798895
96MP0000427_abnormal_hair_cycle0.85587585
97MP0003828_pulmonary_edema0.85454810
98MP0002405_respiratory_system_inflammati0.85292254
99MP0000653_abnormal_sex_gland0.84912248
100MP0002429_abnormal_blood_cell0.83838256
101MP0003453_abnormal_keratinocyte_physiol0.83255676
102MP0002111_abnormal_tail_morphology0.81066631
103MP0003935_abnormal_craniofacial_develop0.80688277
104MP0001873_stomach_inflammation0.80580439
105MP0005671_abnormal_response_to0.80577907
106MP0001849_ear_inflammation0.78678276
107MP0000685_abnormal_immune_system0.77743015
108MP0006072_abnormal_retinal_apoptosis0.77095745
109MP0003300_gastrointestinal_ulcer0.76726867
110MP0002420_abnormal_adaptive_immunity0.76593355
111MP0005621_abnormal_cell_physiology0.76575380
112MP0000627_abnormal_mammary_gland0.75953864
113MP0001819_abnormal_immune_cell0.75685744
114MP0003091_abnormal_cell_migration0.75553848
115MP0001853_heart_inflammation0.74539704
116MP0004947_skin_inflammation0.73741272
117MP0006054_spinal_hemorrhage0.72180459
118MP0002723_abnormal_immune_serum0.72154004
119MP0003303_peritoneal_inflammation0.72026737
120MP0010155_abnormal_intestine_physiology0.70708968
121MP0001919_abnormal_reproductive_system0.70146485
122MP0002928_abnormal_bile_duct0.70033767
123MP0002095_abnormal_skin_pigmentation0.69191756
124MP0003698_abnormal_male_reproductive0.68309553
125MP0009115_abnormal_fat_cell0.67667509
126MP0005384_cellular_phenotype0.66627032
127MP0003755_abnormal_palate_morphology0.66109188
128MP0003718_maternal_effect0.65964833
129MP0001188_hyperpigmentation0.65059889
130MP0001243_abnormal_dermal_layer0.65045208
131MP0005647_abnormal_sex_gland0.64631794
132MP0005408_hypopigmentation0.63875657
133MP0005266_abnormal_metabolism0.63162639

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.43978198
2Chromsome breakage (HP:0040012)3.26056250
3Nephroblastoma (Wilms tumor) (HP:0002667)3.08893800
4Abnormality of the fingertips (HP:0001211)2.97748979
5Birth length less than 3rd percentile (HP:0003561)2.91495000
6Embryonal renal neoplasm (HP:0011794)2.91406156
7Ectopic kidney (HP:0000086)2.82993263
8Deviation of the thumb (HP:0009603)2.80732433
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77604640
10Proximal placement of thumb (HP:0009623)2.75759130
11Abnormality of chromosome stability (HP:0003220)2.68638531
12Colon cancer (HP:0003003)2.66357549
13Ependymoma (HP:0002888)2.66261995
14Medulloblastoma (HP:0002885)2.65940261
15Clubbing of toes (HP:0100760)2.53625783
16Short 4th metacarpal (HP:0010044)2.53482953
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53482953
18Long eyelashes (HP:0000527)2.45326106
19Sloping forehead (HP:0000340)2.44699633
20Impulsivity (HP:0100710)2.42239855
21Papillary thyroid carcinoma (HP:0002895)2.40580975
22Selective tooth agenesis (HP:0001592)2.40347392
23Rhabdomyosarcoma (HP:0002859)2.38905707
24T lymphocytopenia (HP:0005403)2.35382534
25Abnormality of the labia minora (HP:0012880)2.29066653
26Myelodysplasia (HP:0002863)2.26931756
27Panhypogammaglobulinemia (HP:0003139)2.26766365
28Reticulocytopenia (HP:0001896)2.25144778
29Subacute progressive viral hepatitis (HP:0006572)2.25141924
30Biliary tract neoplasm (HP:0100574)2.23651186
31Abnormality of T cell number (HP:0011839)2.22615775
32Sparse lateral eyebrow (HP:0005338)2.22479771
33Acute myeloid leukemia (HP:0004808)2.19767051
34Meckel diverticulum (HP:0002245)2.18351569
35Neoplasm of the oral cavity (HP:0100649)2.16791686
36Oligodactyly (hands) (HP:0001180)2.16750774
37Fair hair (HP:0002286)2.15944326
38Neoplasm of the adrenal cortex (HP:0100641)2.15753169
39Acute lymphatic leukemia (HP:0006721)2.15452039
40Absent radius (HP:0003974)2.13816281
41Patellar aplasia (HP:0006443)2.13661227
42Agnosia (HP:0010524)2.11628606
43Submucous cleft hard palate (HP:0000176)2.08963514
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.07950258
45Cystic hygroma (HP:0000476)2.07045138
46Breast hypoplasia (HP:0003187)2.06715617
47Increased nuchal translucency (HP:0010880)2.06385674
48Prominent nose (HP:0000448)2.05610336
49Abnormal number of incisors (HP:0011064)2.05461057
50Basal cell carcinoma (HP:0002671)2.05356634
51Supernumerary ribs (HP:0005815)2.04030126
52Abnormality of the ileum (HP:0001549)2.03770134
53Curly hair (HP:0002212)2.03084946
54Aplasia/Hypoplasia of the patella (HP:0006498)2.02555871
55Lip pit (HP:0100267)2.01883953
56Facial hemangioma (HP:0000329)2.01351796
57Abnormality of the preputium (HP:0100587)2.01162402
58Aplasia/hypoplasia of the humerus (HP:0006507)2.01041749
59Abnormality of the astrocytes (HP:0100707)2.00947359
60Astrocytoma (HP:0009592)2.00947359
61Chronic hepatic failure (HP:0100626)2.00822599
62Deep philtrum (HP:0002002)2.00237959
63Truncal obesity (HP:0001956)1.97791990
64Amaurosis fugax (HP:0100576)1.97637254
6511 pairs of ribs (HP:0000878)1.96682785
66IgM deficiency (HP:0002850)1.96217219
67Abnormality of the duodenum (HP:0002246)1.95982180
68Gastrointestinal carcinoma (HP:0002672)1.95180684
69Malignant gastrointestinal tract tumors (HP:0006749)1.95180684
70Stomach cancer (HP:0012126)1.94738505
71Neoplasm of the tracheobronchial system (HP:0100552)1.94655278
72Aplasia involving forearm bones (HP:0009822)1.94417955
73Absent forearm bone (HP:0003953)1.94417955
74Short humerus (HP:0005792)1.94207093
75Atresia of the external auditory canal (HP:0000413)1.94117814
76Neoplasm of striated muscle (HP:0009728)1.94004850
77Autoimmune hemolytic anemia (HP:0001890)1.91556648
78Supernumerary bones of the axial skeleton (HP:0009144)1.91055949
79Abnormality of the nasal septum (HP:0000419)1.89969638
80Hypoplastic iliac wings (HP:0002866)1.89753079
81Rib fusion (HP:0000902)1.89314103
82Abnormality of the carotid arteries (HP:0005344)1.88966104
83Dyschromatopsia (HP:0007641)1.88783279
84Low anterior hairline (HP:0000294)1.88630129
85Spinal cord lesions (HP:0100561)1.87757262
86Syringomyelia (HP:0003396)1.87757262
87Abnormality of DNA repair (HP:0003254)1.85943435
88Sandal gap (HP:0001852)1.85733630
89Duodenal stenosis (HP:0100867)1.85479473
90Small intestinal stenosis (HP:0012848)1.85479473
91Hip dysplasia (HP:0001385)1.85146281
92Large earlobe (HP:0009748)1.83248420
93Cutis marmorata (HP:0000965)1.83080774
94Glioma (HP:0009733)1.82498396
95Pancreatic cysts (HP:0001737)1.82239098
96Abnormal hair whorl (HP:0010721)1.81493205
97Combined immunodeficiency (HP:0005387)1.80830713
98Lymphoma (HP:0002665)1.80738706
99Abnormality of chromosome segregation (HP:0002916)1.78867059
100Increased density of long bones (HP:0006392)1.78861006
101Viral hepatitis (HP:0006562)1.77837004
102Squamous cell carcinoma (HP:0002860)1.75984135
103Skull defect (HP:0001362)1.75504756
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.75391307
105Limited elbow extension (HP:0001377)1.74846136
106Broad thumb (HP:0011304)1.74693729
107Pancreatic islet-cell hyperplasia (HP:0004510)1.74507580
108Anal stenosis (HP:0002025)1.74353841
109Absent thumb (HP:0009777)1.73818210
110Skin tags (HP:0010609)1.73774828
111Abnormality of T cells (HP:0002843)1.73588057
112Pancreatic fibrosis (HP:0100732)1.73387920
113Blepharitis (HP:0000498)1.73327813
114Supernumerary spleens (HP:0009799)1.72499041
115Cafe-au-lait spot (HP:0000957)1.72312531
116Osteolytic defects of the hand bones (HP:0009699)1.71058261
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.71058261
118Severe combined immunodeficiency (HP:0004430)1.70360530
119Abnormal lung lobation (HP:0002101)1.70282985
120Abnormality of the 4th metacarpal (HP:0010012)1.67889398
121Duplicated collecting system (HP:0000081)1.67616499
122Hypoplasia of the thymus (HP:0000778)1.67600916
123Neoplasm of the pancreas (HP:0002894)1.67316425
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67292540
125Cutaneous melanoma (HP:0012056)1.66855029
126Urethral obstruction (HP:0000796)1.66606547
127Recurrent viral infections (HP:0004429)1.66377767
128Thyroiditis (HP:0100646)1.66337002
129Arteriovenous malformation (HP:0100026)1.66185034
130Depressed nasal tip (HP:0000437)1.66097027
131Hematochezia (HP:0002573)1.65918839
132Embryonal neoplasm (HP:0002898)1.65758986
133Thyroid carcinoma (HP:0002890)1.65293111
134Overlapping toe (HP:0001845)1.65092803
135Intestinal atresia (HP:0011100)1.64866709
136B lymphocytopenia (HP:0010976)1.64835741
137Abnormality of B cell number (HP:0010975)1.64835741
138Transitional cell carcinoma of the bladder (HP:0006740)1.64815060
139Narrow palate (HP:0000189)1.64693013
140Missing ribs (HP:0000921)1.64563663
141Short middle phalanx of the 5th finger (HP:0004220)1.63998601
142Intestinal fistula (HP:0100819)1.63210006
143Abnormality of the pons (HP:0007361)1.62250847
144Abnormality of the septum pellucidum (HP:0007375)1.62064737
145Abnormal delayed hypersensitivity skin test (HP:0002963)1.61965526
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61940238
147Neonatal hypoglycemia (HP:0001998)1.61733866
148Clitoromegaly (HP:0000057)1.60793507
149Preauricular skin tag (HP:0000384)1.60564662
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.60423882
151Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60272346
152Bladder neoplasm (HP:0009725)1.59619687
153Bladder carcinoma (HP:0002862)1.59619687
154Abnormal biliary tract morphology (HP:0012440)1.59463977
155Cupped ear (HP:0000378)1.57668407
156Breast carcinoma (HP:0003002)1.57119597
157Aqueductal stenosis (HP:0002410)1.56748398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.09079129
2CDC73.80767628
3WEE12.56838968
4NEK22.42417536
5SRPK12.37069677
6MKNK12.17408371
7LATS12.16769659
8TSSK62.04042970
9STK102.00192440
10BUB11.98358178
11TTK1.87245552
12MAP3K101.87160797
13BRD41.86021309
14PLK41.74078796
15RPS6KA41.73710747
16ACVR1B1.72754005
17STK31.70284430
18RPS6KB21.66691227
19MKNK21.65226776
20EPHA21.60476330
21AKT31.59805595
22BRSK21.57987936
23ATR1.57971039
24EEF2K1.55431152
25CDK41.52050957
26EIF2AK11.51130310
27MAP4K11.50965896
28CDK61.44169747
29CAMK1G1.43410516
30CHEK11.41852194
31CDK71.41393568
32AURKB1.41350314
33STK41.39243502
34PIM11.39219370
35PLK11.38056821
36INSRR1.37204443
37PLK31.36625591
38TAOK31.34142692
39MELK1.33575644
40TRIM281.32179238
41MAP3K81.23903079
42CHEK21.23668897
43TGFBR11.23289217
44TNIK1.22146770
45PASK1.22088355
46IRAK11.18879097
47ATM1.18633997
48ALK1.17861723
49BMPR1B1.16053020
50BMPR21.15971240
51DYRK31.15165445
52TXK1.06859049
53MST41.04594577
54JAK31.04235431
55ERBB31.00179866
56SGK20.97462535
57TAF10.95499680
58CHUK0.95019845
59SIK30.94384346
60MTOR0.94083928
61CDK20.93786466
62WNK30.93515821
63TLK10.93323936
64EIF2AK30.92823906
65FGFR30.87295050
66PBK0.85140579
67MAP3K140.85033042
68WNK10.84034180
69ZAK0.83211713
70STK390.82220802
71RPS6KA50.81172952
72MAP3K40.81025501
73CDK90.80986003
74NUAK10.80020552
75NEK60.79123946
76IRAK40.78835595
77IKBKE0.77798572
78PLK20.75957785
79BTK0.75880496
80STK240.75749194
81PIK3CG0.74445143
82LRRK20.74349191
83BCR0.72052643
84FGFR10.71237981
85FLT30.70690554
86CDK10.70606508
87MARK30.69933012
88VRK10.69350912
89PDGFRB0.69223533
90NLK0.68988819
91ITK0.68087844
92PNCK0.66309789
93TRPM70.64933138
94TYK20.64038720
95TTN0.63774639
96PAK40.63759602
97IRAK20.63022150
98PIK3CA0.62575384
99EIF2AK20.62180477
100IKBKB0.60738237
101FGFR20.59997571
102CSF1R0.59643360
103NEK90.59219185
104GRK60.58631619
105CAMK1D0.58618908
106MAP3K20.58557665
107NEK10.57667015
108PAK20.57462609
109SGK30.57370967
110PKN20.56919826
111JAK10.56812805
112CDK30.56159335
113CSNK1D0.55555502
114OXSR10.54094679
115* CSNK2A20.51992903
116FGFR40.51869856
117CAMKK20.50380238
118PTK60.50353518
119STK38L0.50077105
120CSK0.47389574
121CLK10.47266689
122FRK0.46262194
123YES10.45925162
124MAPK140.45623946
125PRKDC0.45274795
126TEC0.44310680
127CSNK1E0.44241317
128MAP2K30.43536239
129HCK0.43039674
130CDK80.42596876
131MAP3K30.42208119
132LCK0.41912361
133MAPK10.41020136
134BMX0.40061265

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45328148
2DNA replication_Homo sapiens_hsa030303.09417652
3Mismatch repair_Homo sapiens_hsa034302.99094421
4RNA transport_Homo sapiens_hsa030132.91143498
5Spliceosome_Homo sapiens_hsa030402.87460118
6One carbon pool by folate_Homo sapiens_hsa006702.67549674
7Cell cycle_Homo sapiens_hsa041102.64534340
8Non-homologous end-joining_Homo sapiens_hsa034502.39987465
9Homologous recombination_Homo sapiens_hsa034402.07155131
10Nucleotide excision repair_Homo sapiens_hsa034202.01481762
11mRNA surveillance pathway_Homo sapiens_hsa030152.00697380
12Fanconi anemia pathway_Homo sapiens_hsa034601.97048389
13Base excision repair_Homo sapiens_hsa034101.86733313
14RNA polymerase_Homo sapiens_hsa030201.80999774
15RNA degradation_Homo sapiens_hsa030181.79327422
16Systemic lupus erythematosus_Homo sapiens_hsa053221.79142839
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75534347
18p53 signaling pathway_Homo sapiens_hsa041151.74328104
19Ribosome_Homo sapiens_hsa030101.58283595
20Basal transcription factors_Homo sapiens_hsa030221.56483244
21Viral carcinogenesis_Homo sapiens_hsa052031.54923805
22Herpes simplex infection_Homo sapiens_hsa051681.52496252
23MicroRNAs in cancer_Homo sapiens_hsa052061.51745393
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.49999059
25Dorso-ventral axis formation_Homo sapiens_hsa043201.44647223
26Primary immunodeficiency_Homo sapiens_hsa053401.43494390
27Antigen processing and presentation_Homo sapiens_hsa046121.42024161
28Small cell lung cancer_Homo sapiens_hsa052221.37113755
29Epstein-Barr virus infection_Homo sapiens_hsa051691.29678485
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29018964
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23238906
32HTLV-I infection_Homo sapiens_hsa051661.18324489
33Measles_Homo sapiens_hsa051621.16150414
34Pyrimidine metabolism_Homo sapiens_hsa002401.16107810
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11526126
36Chronic myeloid leukemia_Homo sapiens_hsa052201.07842718
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05996764
38Adherens junction_Homo sapiens_hsa045201.05750113
39TGF-beta signaling pathway_Homo sapiens_hsa043501.05062618
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04837388
41Inositol phosphate metabolism_Homo sapiens_hsa005621.00293336
42Viral myocarditis_Homo sapiens_hsa054160.97320578
43Proteasome_Homo sapiens_hsa030500.95472076
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93511074
45Circadian rhythm_Homo sapiens_hsa047100.92920550
46Lysine degradation_Homo sapiens_hsa003100.92587682
47Hepatitis B_Homo sapiens_hsa051610.91977084
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.91165487
49Legionellosis_Homo sapiens_hsa051340.90076094
50T cell receptor signaling pathway_Homo sapiens_hsa046600.89965149
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87303565
52Prostate cancer_Homo sapiens_hsa052150.87085092
53Allograft rejection_Homo sapiens_hsa053300.85540492
54Selenocompound metabolism_Homo sapiens_hsa004500.83959591
55Basal cell carcinoma_Homo sapiens_hsa052170.81806395
56Apoptosis_Homo sapiens_hsa042100.81178320
57Colorectal cancer_Homo sapiens_hsa052100.81173677
58Prolactin signaling pathway_Homo sapiens_hsa049170.80672332
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80397800
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78731765
61Hematopoietic cell lineage_Homo sapiens_hsa046400.78530179
62Hippo signaling pathway_Homo sapiens_hsa043900.78500311
63Thyroid cancer_Homo sapiens_hsa052160.78166543
64Notch signaling pathway_Homo sapiens_hsa043300.77431350
65Influenza A_Homo sapiens_hsa051640.76786473
66B cell receptor signaling pathway_Homo sapiens_hsa046620.76566055
67Leishmaniasis_Homo sapiens_hsa051400.75855193
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72691338
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71517849
70Graft-versus-host disease_Homo sapiens_hsa053320.71120909
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.70932295
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.70626414
73Toxoplasmosis_Homo sapiens_hsa051450.70306033
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70250342
75Pancreatic cancer_Homo sapiens_hsa052120.70021417
76Acute myeloid leukemia_Homo sapiens_hsa052210.67639227
77Proteoglycans in cancer_Homo sapiens_hsa052050.66356506
78Caffeine metabolism_Homo sapiens_hsa002320.66282650
79Pathways in cancer_Homo sapiens_hsa052000.66209522
80TNF signaling pathway_Homo sapiens_hsa046680.64533043
81FoxO signaling pathway_Homo sapiens_hsa040680.60625442
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60384609
83mTOR signaling pathway_Homo sapiens_hsa041500.58796150
84Autoimmune thyroid disease_Homo sapiens_hsa053200.58477046
85Osteoclast differentiation_Homo sapiens_hsa043800.57214295
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56463625
87Regulation of autophagy_Homo sapiens_hsa041400.55838754
88Protein export_Homo sapiens_hsa030600.54476524
89Shigellosis_Homo sapiens_hsa051310.54272636
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50900822
91Choline metabolism in cancer_Homo sapiens_hsa052310.50310430
92ErbB signaling pathway_Homo sapiens_hsa040120.49936829
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49778667
94Oocyte meiosis_Homo sapiens_hsa041140.48708996
95Melanoma_Homo sapiens_hsa052180.48327568
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47782662
97Glioma_Homo sapiens_hsa052140.47697388
98Asthma_Homo sapiens_hsa053100.46700494
99Chemokine signaling pathway_Homo sapiens_hsa040620.43906690
100Purine metabolism_Homo sapiens_hsa002300.43514061
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43021251
102HIF-1 signaling pathway_Homo sapiens_hsa040660.42890721
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41310099
104Fatty acid biosynthesis_Homo sapiens_hsa000610.41265638
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41233367
106Alcoholism_Homo sapiens_hsa050340.40536631
107Wnt signaling pathway_Homo sapiens_hsa043100.40151570
108Type II diabetes mellitus_Homo sapiens_hsa049300.39779897
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39400991
110Non-small cell lung cancer_Homo sapiens_hsa052230.39150310
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39015717
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38701232
113Focal adhesion_Homo sapiens_hsa045100.38503422
114Hepatitis C_Homo sapiens_hsa051600.38115312
115Bladder cancer_Homo sapiens_hsa052190.36954690
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.36376048
117Hedgehog signaling pathway_Homo sapiens_hsa043400.35471416
118Renal cell carcinoma_Homo sapiens_hsa052110.34525619
119ECM-receptor interaction_Homo sapiens_hsa045120.34365799
120Endometrial cancer_Homo sapiens_hsa052130.34155003

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