CHD1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.56665465
2proline biosynthetic process (GO:0006561)4.47315827
3DNA unwinding involved in DNA replication (GO:0006268)4.35163560
4DNA strand elongation involved in DNA replication (GO:0006271)4.34795125
5nuclear pore complex assembly (GO:0051292)4.30292659
6nuclear pore organization (GO:0006999)4.15792451
7DNA strand elongation (GO:0022616)4.13209138
8telomere maintenance via semi-conservative replication (GO:0032201)4.08203475
9DNA replication initiation (GO:0006270)3.98205700
10protein localization to kinetochore (GO:0034501)3.90427651
11DNA topological change (GO:0006265)3.80770079
12mitotic chromosome condensation (GO:0007076)3.79623133
13protein localization to chromosome, centromeric region (GO:0071459)3.72270315
14maturation of SSU-rRNA (GO:0030490)3.69066190
15viral transcription (GO:0019083)3.66412798
16DNA ligation (GO:0006266)3.64222382
17ribosome assembly (GO:0042255)3.64207465
18IMP biosynthetic process (GO:0006188)3.63404619
19DNA replication-dependent nucleosome assembly (GO:0006335)3.62930811
20DNA replication-dependent nucleosome organization (GO:0034723)3.62930811
21telomere maintenance via recombination (GO:0000722)3.62643368
22mitotic nuclear envelope disassembly (GO:0007077)3.62487503
23translational termination (GO:0006415)3.60180113
24folic acid-containing compound biosynthetic process (GO:0009396)3.51761120
25mitotic recombination (GO:0006312)3.47519214
26formation of translation preinitiation complex (GO:0001731)3.46843378
27meiotic chromosome segregation (GO:0045132)3.40174967
28IMP metabolic process (GO:0046040)3.36909393
29membrane disassembly (GO:0030397)3.35062359
30nuclear envelope disassembly (GO:0051081)3.35062359
31ribosomal small subunit biogenesis (GO:0042274)3.32962884
32non-recombinational repair (GO:0000726)3.31671288
33double-strand break repair via nonhomologous end joining (GO:0006303)3.31671288
34translational elongation (GO:0006414)3.31518940
35proline metabolic process (GO:0006560)3.27523548
36regulation of RNA export from nucleus (GO:0046831)3.25690602
37* DNA duplex unwinding (GO:0032508)3.24938498
38regulation of histone H3-K9 methylation (GO:0051570)3.24256778
39pore complex assembly (GO:0046931)3.23625376
40* DNA geometric change (GO:0032392)3.23048551
41DNA replication checkpoint (GO:0000076)3.21761303
42piRNA metabolic process (GO:0034587)3.20412480
43kinetochore organization (GO:0051383)3.16956838
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14972135
45chromatin remodeling at centromere (GO:0031055)3.14806314
46chromosome condensation (GO:0030261)3.13679026
47mitotic sister chromatid segregation (GO:0000070)3.13512925
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12749423
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.12425735
50telomere maintenance via telomere lengthening (GO:0010833)3.10162174
51regulation of centriole replication (GO:0046599)3.07562414
52nucleobase biosynthetic process (GO:0046112)3.06545670
53translational initiation (GO:0006413)3.05553766
54mitotic sister chromatid cohesion (GO:0007064)3.04305599
55* DNA conformation change (GO:0071103)3.03027833
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01881878
57regulation of mitotic spindle organization (GO:0060236)3.00374074
58CENP-A containing nucleosome assembly (GO:0034080)2.99932206
59regulation of sister chromatid cohesion (GO:0007063)2.98942385
60binding of sperm to zona pellucida (GO:0007339)2.98739986
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97589305
62somatic hypermutation of immunoglobulin genes (GO:0016446)2.96232342
63somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96232342
64negative regulation of mRNA processing (GO:0050686)2.95687157
65attachment of spindle microtubules to kinetochore (GO:0008608)2.95291637
66mitotic metaphase plate congression (GO:0007080)2.95096283
67DNA packaging (GO:0006323)2.94130250
68DNA deamination (GO:0045006)2.94093521
69ribosomal large subunit biogenesis (GO:0042273)2.92855300
70chromosome segregation (GO:0007059)2.92825939
71translesion synthesis (GO:0019985)2.92261440
72negative regulation of mRNA metabolic process (GO:1903312)2.91938908
73protein targeting to ER (GO:0045047)2.91773325
74heterochromatin organization (GO:0070828)2.91668051
75cotranslational protein targeting to membrane (GO:0006613)2.91621551
76nucleobase-containing small molecule interconversion (GO:0015949)2.90903090
77mitotic G2/M transition checkpoint (GO:0044818)2.90141512
78sister chromatid segregation (GO:0000819)2.89835816
79histone exchange (GO:0043486)2.88699942
80regulation of chromosome segregation (GO:0051983)2.88131614
81DNA replication-independent nucleosome organization (GO:0034724)2.87554278
82DNA replication-independent nucleosome assembly (GO:0006336)2.87554278
83sperm-egg recognition (GO:0035036)2.86326273
84metaphase plate congression (GO:0051310)2.85737280
85ribonucleoprotein complex biogenesis (GO:0022613)2.85692261
86tRNA aminoacylation for protein translation (GO:0006418)2.84276689
87tetrahydrofolate metabolic process (GO:0046653)2.80702559
88positive regulation of histone H3-K4 methylation (GO:0051571)2.79326313
89plasma lipoprotein particle assembly (GO:0034377)2.79265927
90viral life cycle (GO:0019058)2.79117916
91negative regulation of chromosome segregation (GO:0051985)2.78877400
92protein K6-linked ubiquitination (GO:0085020)2.78444511
93DNA strand renaturation (GO:0000733)2.77972823
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77384608
95cellular protein complex disassembly (GO:0043624)2.76669433
96very-low-density lipoprotein particle assembly (GO:0034379)2.75236536
97synaptonemal complex assembly (GO:0007130)2.74594016
98tRNA aminoacylation (GO:0043039)2.74527560
99amino acid activation (GO:0043038)2.74527560
100ribosome biogenesis (GO:0042254)2.72792747
101mitotic spindle checkpoint (GO:0071174)2.72744336
102protein localization to endoplasmic reticulum (GO:0070972)2.71678111
103spindle checkpoint (GO:0031577)2.71634994
104establishment of chromosome localization (GO:0051303)2.70971124
105chromosome organization involved in meiosis (GO:0070192)2.68988020
106negative regulation of sister chromatid segregation (GO:0033046)2.68854387
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68854387
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68854387
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68854387
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.68854387
111viral mRNA export from host cell nucleus (GO:0046784)2.68728699
112negative regulation of RNA splicing (GO:0033119)2.68512132
113chromatin assembly or disassembly (GO:0006333)2.68108635
114telomere maintenance (GO:0000723)2.68042795
115cell-cell recognition (GO:0009988)2.68040213
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66892732
117telomere organization (GO:0032200)2.66287829
118mitotic spindle assembly checkpoint (GO:0007094)2.65758182
119nuclear-transcribed mRNA catabolic process (GO:0000956)2.64920996
120regulation of translational fidelity (GO:0006450)2.63136197
121establishment of viral latency (GO:0019043)2.62976792
122purine nucleobase biosynthetic process (GO:0009113)2.62922720
123rRNA processing (GO:0006364)2.62469088
124protein complex disassembly (GO:0043241)2.62113816
125spindle assembly checkpoint (GO:0071173)2.62095780
126dosage compensation (GO:0007549)2.61512396
127regulation of response to tumor cell (GO:0002834)2.60936160
128positive regulation of response to tumor cell (GO:0002836)2.60936160
129positive regulation of immune response to tumor cell (GO:0002839)2.60936160
130regulation of immune response to tumor cell (GO:0002837)2.60936160
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60924003
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60924003
133rRNA metabolic process (GO:0016072)2.58267485
134chromatin assembly (GO:0031497)2.57969265
135gene silencing by RNA (GO:0031047)2.57947814
136RNA catabolic process (GO:0006401)2.57875275
137positive regulation of chromosome segregation (GO:0051984)2.57424221
138kinetochore assembly (GO:0051382)2.56335907
139male meiosis (GO:0007140)2.56155413
140regulation of centrosome cycle (GO:0046605)2.56083781
141meiotic nuclear division (GO:0007126)2.55919503
142nuclear envelope organization (GO:0006998)2.55812411
143synaptonemal complex organization (GO:0070193)2.55783565
144establishment of integrated proviral latency (GO:0075713)2.55003825
145fusion of sperm to egg plasma membrane (GO:0007342)2.54999584
146regulation of spindle organization (GO:0090224)2.54341607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.64480760
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.99465353
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.47188201
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38588175
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28101509
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13010581
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98445135
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39220527
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.31279456
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29080500
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27469642
12MYC_22102868_ChIP-Seq_BL_Human2.13068553
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.10067235
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95494317
15AR_21909140_ChIP-Seq_LNCAP_Human1.91732218
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91446937
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90294694
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.89051964
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88411992
20XRN2_22483619_ChIP-Seq_HELA_Human1.87788558
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87623253
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.87407241
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.82030002
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81114769
25GATA1_22025678_ChIP-Seq_K562_Human1.80450247
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79236095
27* VDR_23849224_ChIP-Seq_CD4+_Human1.77609332
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76935818
29* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71536423
30FOXP3_21729870_ChIP-Seq_TREG_Human1.71032900
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70972159
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68916282
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64042814
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61288411
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58124490
36DCP1A_22483619_ChIP-Seq_HELA_Human1.50208625
37VDR_21846776_ChIP-Seq_THP-1_Human1.49761550
38ZNF263_19887448_ChIP-Seq_K562_Human1.49052469
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47432578
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47000889
41GABP_19822575_ChIP-Seq_HepG2_Human1.46783583
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44626929
43CIITA_25753668_ChIP-Seq_RAJI_Human1.44117839
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42690372
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40033468
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37396177
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37332516
48KDM5A_27292631_Chip-Seq_BREAST_Human1.34786467
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33789861
50TTF2_22483619_ChIP-Seq_HELA_Human1.32971823
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32259418
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29797720
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29729887
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29416095
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26782967
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26741758
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25759126
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25274423
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24650661
60MYB_26560356_Chip-Seq_TH1_Human1.21505178
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19367426
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18790666
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18618132
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.18593667
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18186246
66* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17280936
67MYB_26560356_Chip-Seq_TH2_Human1.16691623
68SCL_19346495_ChIP-Seq_HPC-7_Human1.16664302
69ELK1_19687146_ChIP-ChIP_HELA_Human1.15857706
70MAF_26560356_Chip-Seq_TH1_Human1.14914443
71SPI1_23547873_ChIP-Seq_NB4_Human1.14761516
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.14445182
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12692374
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12281223
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11752022
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11387993
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11133831
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09943772
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.09224946
80UTX_26944678_Chip-Seq_JUKART_Human1.09211711
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08532242
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08220429
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07694436
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05416316
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03066381
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03011392
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01570499
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00727695
89TFEB_21752829_ChIP-Seq_HELA_Human0.99646144
90RUNX1_22412390_ChIP-Seq_EML_Mouse0.99134243
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97818055
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97801698
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96448258
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96336463
95BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95455608
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95301910
97* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95099946
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.94623547
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.94344219
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94160487
101TCF7_22412390_ChIP-Seq_EML_Mouse0.92908251
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92270253
103MAF_26560356_Chip-Seq_TH2_Human0.92159204
104* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90377038
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90048699
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89958703
107GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89666263
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.89665351
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89106178
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87454687
111NCOR1_26117541_ChIP-Seq_K562_Human0.86579999
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85319943
113CHD1_26751641_Chip-Seq_LNCaP_Human0.85233816
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83930260
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82694731
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82439161
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82373160
118MYC_18940864_ChIP-ChIP_HL60_Human0.81896351
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81277566
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80218345
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80218345
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80218345
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.80122372
124CLOCK_20551151_ChIP-Seq_293T_Human0.79847973
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79447463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.90852144
2MP0010094_abnormal_chromosome_stability3.90387630
3MP0003693_abnormal_embryo_hatching3.82128482
4MP0004957_abnormal_blastocyst_morpholog3.24333658
5MP0003111_abnormal_nucleus_morphology3.24178581
6MP0003077_abnormal_cell_cycle3.00244267
7MP0002396_abnormal_hematopoietic_system2.80366759
8MP0008058_abnormal_DNA_repair2.58084157
9MP0008877_abnormal_DNA_methylation2.42789285
10MP0009697_abnormal_copulation2.34204664
11MP0003763_abnormal_thymus_physiology2.28772704
12MP0008007_abnormal_cellular_replicative2.28693809
13MP0005410_abnormal_fertilization2.23142915
14MP0010352_gastrointestinal_tract_polyps1.99672492
15MP0001730_embryonic_growth_arrest1.82757420
16MP0000490_abnormal_crypts_of1.81727387
17MP0000685_abnormal_immune_system1.79782350
18MP0010307_abnormal_tumor_latency1.78415733
19MP0004808_abnormal_hematopoietic_stem1.77618796
20MP0003786_premature_aging1.74627996
21MP0005397_hematopoietic_system_phenotyp1.66742628
22MP0001545_abnormal_hematopoietic_system1.66742628
23MP0000350_abnormal_cell_proliferation1.64686572
24MP0001929_abnormal_gametogenesis1.63635776
25MP0002398_abnormal_bone_marrow1.60213040
26MP0001661_extended_life_span1.59820879
27MP0005408_hypopigmentation1.57824961
28MP0004147_increased_porphyrin_level1.57332060
29MP0009672_abnormal_birth_weight1.52951276
30MP0002139_abnormal_hepatobiliary_system1.52942330
31MP0003718_maternal_effect1.52412672
32MP0002877_abnormal_melanocyte_morpholog1.52238828
33MP0002166_altered_tumor_susceptibility1.51408504
34MP0003806_abnormal_nucleotide_metabolis1.49146728
35MP0002019_abnormal_tumor_incidence1.48322249
36MP0008932_abnormal_embryonic_tissue1.47460647
37MP0002210_abnormal_sex_determination1.46931569
38MP0000703_abnormal_thymus_morphology1.46810946
39MP0002722_abnormal_immune_system1.44879327
40MP0000689_abnormal_spleen_morphology1.44123618
41MP0001666_abnormal_nutrient_absorption1.42028352
42MP0001835_abnormal_antigen_presentation1.41130332
43MP0001800_abnormal_humoral_immune1.40191243
44MP0009333_abnormal_splenocyte_physiolog1.33989270
45MP0005058_abnormal_lysosome_morphology1.29735636
46MP0000313_abnormal_cell_death1.29530142
47MP0001145_abnormal_male_reproductive1.29290841
48MP0005380_embryogenesis_phenotype1.28879976
49MP0001672_abnormal_embryogenesis/_devel1.28879976
50MP0003943_abnormal_hepatobiliary_system1.26156385
51MP0001697_abnormal_embryo_size1.24357279
52MP0002429_abnormal_blood_cell1.23970686
53MP0000716_abnormal_immune_system1.21906969
54MP0002405_respiratory_system_inflammati1.21120079
55MP0000372_irregular_coat_pigmentation1.20646959
56MP0003984_embryonic_growth_retardation1.20247964
57MP0006054_spinal_hemorrhage1.20078782
58MP0002080_prenatal_lethality1.19396808
59MP0001873_stomach_inflammation1.18257175
60MP0001853_heart_inflammation1.17423707
61MP0002088_abnormal_embryonic_growth/wei1.16637396
62MP0004185_abnormal_adipocyte_glucose1.16226643
63MP0010155_abnormal_intestine_physiology1.15771064
64MP0003941_abnormal_skin_development1.15531488
65MP0009278_abnormal_bone_marrow1.14897844
66MP0002420_abnormal_adaptive_immunity1.14322149
67MP0005671_abnormal_response_to1.14252826
68MP0003698_abnormal_male_reproductive1.13860295
69MP0005075_abnormal_melanosome_morpholog1.13668994
70MP0002086_abnormal_extraembryonic_tissu1.12963152
71MP0004197_abnormal_fetal_growth/weight/1.12302063
72MP0005076_abnormal_cell_differentiation1.11941569
73MP0001819_abnormal_immune_cell1.11685855
74MP0003656_abnormal_erythrocyte_physiolo1.11669718
75MP0002452_abnormal_antigen_presenting1.10456680
76MP0002006_tumorigenesis1.09243909
77MP0002723_abnormal_immune_serum1.08718584
78MP0006035_abnormal_mitochondrial_morpho1.08668469
79MP0000653_abnormal_sex_gland1.06804128
80MP0005384_cellular_phenotype1.04744232
81MP0004264_abnormal_extraembryonic_tissu1.04212820
82MP0008260_abnormal_autophagy1.01913868
83MP0005621_abnormal_cell_physiology0.99709254
84MP0005025_abnormal_response_to0.98126928
85MP0003186_abnormal_redox_activity0.98111489
86MP0002085_abnormal_embryonic_tissue0.97572220
87MP0000609_abnormal_liver_physiology0.97542635
88MP0005464_abnormal_platelet_physiology0.93394855
89MP0002084_abnormal_developmental_patter0.93272709
90MP0005387_immune_system_phenotype0.92224220
91MP0001790_abnormal_immune_system0.92224220
92MP0004272_abnormal_basement_membrane0.91141173
93MP0005365_abnormal_bile_salt0.90038031
94MP0003436_decreased_susceptibility_to0.89476457
95MP0002009_preneoplasia0.88926115
96MP0003566_abnormal_cell_adhesion0.88335761
97MP0004947_skin_inflammation0.88329419
98MP0009785_altered_susceptibility_to0.88293170
99MP0005023_abnormal_wound_healing0.88228167
100MP0003315_abnormal_perineum_morphology0.86813305
101MP0005360_urolithiasis0.86409894
102MP0001849_ear_inflammation0.85462303
103MP0003950_abnormal_plasma_membrane0.84908599
104MP0002132_abnormal_respiratory_system0.84866058
105MP0005000_abnormal_immune_tolerance0.84294860
106MP0005220_abnormal_exocrine_pancreas0.83756127
107MP0001764_abnormal_homeostasis0.83633214
108MP0003300_gastrointestinal_ulcer0.82787739
109MP0001881_abnormal_mammary_gland0.81550753
110MP0000858_altered_metastatic_potential0.81032577
111MP0000477_abnormal_intestine_morphology0.80054035
112MP0003866_abnormal_defecation0.78539121
113MP0008995_early_reproductive_senescence0.78115090
114MP0000465_gastrointestinal_hemorrhage0.77179830
115MP0006036_abnormal_mitochondrial_physio0.76970783
116MP0009703_decreased_birth_body0.76940666
117MP0005501_abnormal_skin_physiology0.76670358
118MP0005174_abnormal_tail_pigmentation0.75541493
119MP0010329_abnormal_lipoprotein_level0.75532449
120MP0002160_abnormal_reproductive_system0.74831767
121MP0003453_abnormal_keratinocyte_physiol0.73338752
122MP0002161_abnormal_fertility/fecundity0.71539153
123MP0001293_anophthalmia0.71489009
124MP0001845_abnormal_inflammatory_respons0.71151703
125MP0004233_abnormal_muscle_weight0.70775535
126MP0006292_abnormal_olfactory_placode0.70708684
127MP0000358_abnormal_cell_content/0.70493459
128MP0002938_white_spotting0.69405834
129MP0003567_abnormal_fetal_cardiomyocyte0.67425590
130MP0001915_intracranial_hemorrhage0.66832850
131MP0003890_abnormal_embryonic-extraembry0.66602139
132MP0003705_abnormal_hypodermis_morpholog0.66380090
133MP0003123_paternal_imprinting0.66363795
134MP0002796_impaired_skin_barrier0.66309282
135MP0000598_abnormal_liver_morphology0.65030257
136MP0003699_abnormal_female_reproductive0.64890591
137MP0002697_abnormal_eye_size0.64349197
138MP0005666_abnormal_adipose_tissue0.59947181

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.47180701
2Abnormality of cells of the erythroid lineage (HP:0012130)4.03466265
3Abnormal number of erythroid precursors (HP:0012131)3.93812903
4Nasal polyposis (HP:0100582)3.68308200
5Thrombocytosis (HP:0001894)3.67408704
6Hypobetalipoproteinemia (HP:0003563)3.43890781
7Chromsome breakage (HP:0040012)3.35462451
8Deep venous thrombosis (HP:0002625)3.28963090
911 pairs of ribs (HP:0000878)3.24989323
10Selective tooth agenesis (HP:0001592)3.19723584
11Nephroblastoma (Wilms tumor) (HP:0002667)3.15248699
12IgM deficiency (HP:0002850)3.14938844
13Abnormality of the nasal mucosa (HP:0000433)3.14306339
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09576493
15Increased mean platelet volume (HP:0011877)3.04233172
16Abnormality of the common coagulation pathway (HP:0010990)3.00843837
17Acute lymphatic leukemia (HP:0006721)3.00035835
18Recurrent bronchitis (HP:0002837)2.94815519
19Ependymoma (HP:0002888)2.94587601
20Abnormality of chromosome stability (HP:0003220)2.93900158
21Abnormality of methionine metabolism (HP:0010901)2.92201949
22Embryonal renal neoplasm (HP:0011794)2.91269078
23Abnormality of the preputium (HP:0100587)2.85783018
24Myelodysplasia (HP:0002863)2.83101578
25Abnormal gallbladder physiology (HP:0012438)2.81485412
26Cholecystitis (HP:0001082)2.81485412
27Abnormality of the anterior horn cell (HP:0006802)2.79864133
28Degeneration of anterior horn cells (HP:0002398)2.79864133
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79639840
30Absent thumb (HP:0009777)2.78964944
31Basal cell carcinoma (HP:0002671)2.74144711
32Colon cancer (HP:0003003)2.70826250
33Prolonged partial thromboplastin time (HP:0003645)2.70140898
34Acanthocytosis (HP:0001927)2.69141388
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.68751920
36Medulloblastoma (HP:0002885)2.68287565
37Menorrhagia (HP:0000132)2.65546460
38Abnormal platelet volume (HP:0011876)2.64987613
39Aplastic anemia (HP:0001915)2.62379976
40Bronchitis (HP:0012387)2.58823173
41Microvesicular hepatic steatosis (HP:0001414)2.52395085
42Impulsivity (HP:0100710)2.52337485
43Abnormality of the fingertips (HP:0001211)2.52003685
44Pallor (HP:0000980)2.51700240
45Birth length less than 3rd percentile (HP:0003561)2.48475190
46Increased nuchal translucency (HP:0010880)2.48238802
47Pancreatic islet-cell hyperplasia (HP:0004510)2.46526033
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.39551234
49Meckel diverticulum (HP:0002245)2.38211349
50Prolonged bleeding time (HP:0003010)2.36605393
51T lymphocytopenia (HP:0005403)2.36597088
52Oral leukoplakia (HP:0002745)2.34202091
53Macrocytic anemia (HP:0001972)2.33291889
54Abnormality of the ileum (HP:0001549)2.33222604
55Abnormality of T cells (HP:0002843)2.32059225
56Amaurosis fugax (HP:0100576)2.31404528
57Abnormality of DNA repair (HP:0003254)2.30538876
58Short middle phalanx of the 5th finger (HP:0004220)2.29752249
59Abnormality of glycolysis (HP:0004366)2.29714769
60Prominent nose (HP:0000448)2.29690233
61Spontaneous abortion (HP:0005268)2.29348750
62Squamous cell carcinoma (HP:0002860)2.26558331
63Recurrent sinusitis (HP:0011108)2.26182546
64Progressive external ophthalmoplegia (HP:0000590)2.25861447
65Poikiloderma (HP:0001029)2.24976136
66Abnormality of oral frenula (HP:0000190)2.23120652
67Abnormality of T cell number (HP:0011839)2.21348115
68Abnormality of pyrimidine metabolism (HP:0004353)2.21190198
69Sloping forehead (HP:0000340)2.21098074
70Abnormality of reticulocytes (HP:0004312)2.20431991
71Abnormal spermatogenesis (HP:0008669)2.20327291
72Agnosia (HP:0010524)2.19551012
73Ectopic kidney (HP:0000086)2.18720212
74Asplenia (HP:0001746)2.18591740
75Rhabdomyosarcoma (HP:0002859)2.18336000
76Irregular epiphyses (HP:0010582)2.17070605
77Absent/shortened dynein arms (HP:0200106)2.16994536
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.16994536
79Abnormality of T cell physiology (HP:0011840)2.15862177
80Lymphoma (HP:0002665)2.15609835
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15420897
82Absent epiphyses (HP:0010577)2.15420897
83Bronchiectasis (HP:0002110)2.12704331
84Small intestinal stenosis (HP:0012848)2.11212786
85Duodenal stenosis (HP:0100867)2.11212786
86Bone marrow hypocellularity (HP:0005528)2.07950520
87Abnormality of cochlea (HP:0000375)2.07837549
88Asymmetry of the thorax (HP:0001555)2.07422351
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06943265
90Impaired platelet aggregation (HP:0003540)2.06467492
91Abnormal platelet function (HP:0011869)2.06467492
92High pitched voice (HP:0001620)2.05226716
93Recurrent viral infections (HP:0004429)2.04986147
94Chronic bronchitis (HP:0004469)2.04834655
95Carpal bone hypoplasia (HP:0001498)2.04174437
96Poikilocytosis (HP:0004447)2.04001565
97Missing ribs (HP:0000921)2.03173455
98Premature ovarian failure (HP:0008209)2.01561929
99Elevated erythrocyte sedimentation rate (HP:0003565)1.99446374
100Pancytopenia (HP:0001876)1.99207799
101Ankyloglossia (HP:0010296)1.97797730
102Combined immunodeficiency (HP:0005387)1.97651816
103Embryonal neoplasm (HP:0002898)1.97056894
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.96872837
105Duplicated collecting system (HP:0000081)1.94826641
106Increased serum pyruvate (HP:0003542)1.93430798
107Diastasis recti (HP:0001540)1.93305929
108Orthostatic hypotension (HP:0001278)1.93118163
109Hypercholesterolemia (HP:0003124)1.92631972
110Chronic otitis media (HP:0000389)1.90362128
111Vaginal fistula (HP:0004320)1.90182090
112Volvulus (HP:0002580)1.89712694
113Epistaxis (HP:0000421)1.89670893
114Abnormal foot bone ossification (HP:0010675)1.88405673
115Abnormality of the parathyroid morphology (HP:0011766)1.87981074
116Abnormality of the fetal cardiovascular system (HP:0010948)1.87560639
117Abnormal umbilical cord blood vessels (HP:0011403)1.87560639
118Single umbilical artery (HP:0001195)1.87560639
119Choanal atresia (HP:0000453)1.87462440
120Rectovaginal fistula (HP:0000143)1.87399927
121Rectal fistula (HP:0100590)1.87399927
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87266864
123Hypolipoproteinemia (HP:0010981)1.85893751
124Abnormal lung lobation (HP:0002101)1.85796109
125Acute myeloid leukemia (HP:0004808)1.85263864
126Leukopenia (HP:0001882)1.85060972
127Progressive muscle weakness (HP:0003323)1.84468121
128Pustule (HP:0200039)1.84006591
129Secondary amenorrhea (HP:0000869)1.83653201
130Cafe-au-lait spot (HP:0000957)1.82321476
131Clubbing of toes (HP:0100760)1.82065719
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.81955940
133B lymphocytopenia (HP:0010976)1.81832805
134Abnormality of B cell number (HP:0010975)1.81832805
135Anal stenosis (HP:0002025)1.81686818
136Recurrent otitis media (HP:0000403)1.81243731
137Deep philtrum (HP:0002002)1.81046735
138Horseshoe kidney (HP:0000085)1.80640430
139Reduced antithrombin III activity (HP:0001976)1.80311010
140Reticulocytosis (HP:0001923)1.79473923
141Myositis (HP:0100614)1.79310212
142IgA deficiency (HP:0002720)1.77258633
143Gastrointestinal inflammation (HP:0004386)1.76822564
144Dyschromatopsia (HP:0007641)1.76356338
145Anteriorly placed anus (HP:0001545)1.75401166
146Type I transferrin isoform profile (HP:0003642)1.75348832
147Proximal placement of thumb (HP:0009623)1.75170657
148Cutaneous melanoma (HP:0012056)1.74901087
149Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74348017
150Gingival bleeding (HP:0000225)1.74311976
151Overlapping toe (HP:0001845)1.74080445
152Small epiphyses (HP:0010585)1.73404746
153Purpura (HP:0000979)1.72734155
154Pulmonary fibrosis (HP:0002206)1.72664674
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.72536820
156Breast hypoplasia (HP:0003187)1.72217283
157Abnormality of the umbilical cord (HP:0010881)1.71918127
158Abnormality of the duodenum (HP:0002246)1.71403423
159Enlarged kidneys (HP:0000105)1.71358620
160Deviation of the thumb (HP:0009603)1.70661019
161Neoplasm of the pancreas (HP:0002894)1.70547471
162Multiple enchondromatosis (HP:0005701)1.70343632
163Gonadotropin excess (HP:0000837)1.69468634
164Neoplasm of striated muscle (HP:0009728)1.69203814
165Abnormal respiratory motile cilium morphology (HP:0005938)1.68252789
166Abnormal respiratory epithelium morphology (HP:0012253)1.68252789
167Intestinal fistula (HP:0100819)1.67943740
168Abnormality of the heme biosynthetic pathway (HP:0010472)1.67812649
169Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67364144
170Inflammation of the large intestine (HP:0002037)1.67003059
171Petechiae (HP:0000967)1.66289661
172Biliary tract neoplasm (HP:0100574)1.65744060
173Ovarian neoplasm (HP:0100615)1.65551394
174Abnormality of the calcaneus (HP:0008364)1.65454900
175Abnormality of the intrinsic pathway (HP:0010989)1.65352359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.75661985
2PBK3.59958684
3WEE12.96165573
4NEK22.69746026
5CDK122.57708109
6MAP4K12.53458455
7EEF2K2.50384530
8STK102.38099825
9PDK42.27709940
10PDK32.27709940
11BUB12.27174621
12FLT32.03517173
13SMG11.91289915
14TTK1.86078809
15RPS6KB21.84071554
16PASK1.83371285
17VRK21.77339190
18MAP3K101.74868186
19BRSK21.70558295
20EIF2AK11.69154855
21PKN21.67432302
22ATR1.58212011
23TESK21.56663428
24CDK41.53220460
25ACVR1B1.52614048
26TAF11.50657599
27CDK71.46335242
28PLK11.46019298
29SRPK11.44067671
30RPS6KA41.40743672
31STK41.37349117
32ERBB41.37341982
33NME21.36689002
34AURKB1.32802357
35MAP2K31.32026426
36MAP3K81.31782880
37TESK11.30930674
38ZAP701.20361115
39TLK11.20360209
40BTK1.18997450
41PLK41.17119524
42NEK11.17115265
43PDK21.16770143
44LRRK21.15866968
45JAK31.14940442
46MAPKAPK31.14932561
47CHEK11.14133544
48PIM11.08805228
49MAP3K31.06860033
50TYK21.05998008
51DYRK31.01855422
52CLK11.00252384
53IRAK30.99873000
54CHEK20.99804464
55BCKDK0.99266795
56TGFBR10.98654390
57TEC0.98171446
58GRK60.95520847
59SCYL20.94704152
60MKNK10.94104208
61ERN10.92941430
62KIT0.92090222
63CSF1R0.91724218
64MST40.91092672
65CDK60.90437823
66EIF2AK30.89781999
67ICK0.89184900
68ITK0.87404463
69TSSK60.87105682
70TXK0.86925301
71ATM0.86609573
72PAK40.85230092
73NME10.83476055
74TRIB30.82062105
75EIF2AK20.79109142
76VRK10.78931519
77BMX0.78908531
78CCNB10.78890424
79PNCK0.77701358
80NUAK10.76994432
81FGFR10.73877277
82AURKA0.72292793
83CDK80.72022736
84MAP3K110.67070834
85BRSK10.66027115
86CDK20.65836725
87STK30.64836082
88IKBKB0.64517731
89ILK0.64343265
90KDR0.63789821
91IKBKE0.60454531
92FGFR30.57223295
93LCK0.57129020
94MTOR0.56718232
95CSNK2A20.55975192
96CSK0.55940289
97TTN0.54676076
98ALK0.54243578
99TBK10.54171643
100BRD40.53608387
101PTK60.50242538
102NEK90.50220481
103SIK30.48491030
104MAPK110.48463052
105MELK0.48379456
106SYK0.46653560
107CHUK0.46081660
108MKNK20.45386147
109CSNK2A10.44504680
110PLK30.44282671
111MST1R0.43597757
112CSNK1E0.43569425
113FGFR40.43292190
114MARK30.42974971
115MATK0.42938557
116DAPK10.42279101
117MAP3K140.41865771
118WNK40.41655217
119CDK10.41042624
120ZAK0.40261384
121TRPM70.39863954
122MAPKAPK50.38934685
123PAK20.38439170
124PRKDC0.36053289
125LYN0.35980231
126PAK10.35275131
127STK160.34583613
128CDK90.33685539
129PDGFRA0.28731879
130TRIM280.28208453
131RPS6KB10.26758454
132MAPK140.26750910

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79940457
2Mismatch repair_Homo sapiens_hsa034303.99542163
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04359919
4Ribosome_Homo sapiens_hsa030102.99304445
5Base excision repair_Homo sapiens_hsa034102.96486802
6Homologous recombination_Homo sapiens_hsa034402.74993146
7Spliceosome_Homo sapiens_hsa030402.70900744
8One carbon pool by folate_Homo sapiens_hsa006702.60787100
9RNA transport_Homo sapiens_hsa030132.57083066
10Nucleotide excision repair_Homo sapiens_hsa034202.52190842
11Non-homologous end-joining_Homo sapiens_hsa034502.25432548
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22148690
13Cell cycle_Homo sapiens_hsa041102.19949215
14Fanconi anemia pathway_Homo sapiens_hsa034602.12007475
15Pyrimidine metabolism_Homo sapiens_hsa002401.84710629
16RNA degradation_Homo sapiens_hsa030181.82799422
17Proteasome_Homo sapiens_hsa030501.76833379
18RNA polymerase_Homo sapiens_hsa030201.68239061
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59278904
20Primary immunodeficiency_Homo sapiens_hsa053401.55353991
21mRNA surveillance pathway_Homo sapiens_hsa030151.54893777
22Basal transcription factors_Homo sapiens_hsa030221.50464204
23Selenocompound metabolism_Homo sapiens_hsa004501.46549245
24Fatty acid elongation_Homo sapiens_hsa000621.43940913
25Antigen processing and presentation_Homo sapiens_hsa046121.42482449
26p53 signaling pathway_Homo sapiens_hsa041151.37448006
27Pentose phosphate pathway_Homo sapiens_hsa000301.25899738
28Systemic lupus erythematosus_Homo sapiens_hsa053221.23975301
29Herpes simplex infection_Homo sapiens_hsa051681.22581767
30Steroid biosynthesis_Homo sapiens_hsa001001.14604112
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14255433
32Fatty acid metabolism_Homo sapiens_hsa012121.07727122
33Biosynthesis of amino acids_Homo sapiens_hsa012301.07701195
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.02627182
35Complement and coagulation cascades_Homo sapiens_hsa046101.01905209
36Other glycan degradation_Homo sapiens_hsa005111.01745493
37Viral carcinogenesis_Homo sapiens_hsa052031.01188032
38Sulfur relay system_Homo sapiens_hsa041220.96830099
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96039141
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.94100628
41Epstein-Barr virus infection_Homo sapiens_hsa051690.93491189
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92183388
43Purine metabolism_Homo sapiens_hsa002300.90285172
44Measles_Homo sapiens_hsa051620.89130436
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.83021756
46Carbon metabolism_Homo sapiens_hsa012000.81009879
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79626217
48Folate biosynthesis_Homo sapiens_hsa007900.78417153
49HTLV-I infection_Homo sapiens_hsa051660.75748876
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.73660595
51Legionellosis_Homo sapiens_hsa051340.73073561
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71773209
53Pyruvate metabolism_Homo sapiens_hsa006200.69549133
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69517938
55B cell receptor signaling pathway_Homo sapiens_hsa046620.69495881
56Thyroid cancer_Homo sapiens_hsa052160.69445393
57Starch and sucrose metabolism_Homo sapiens_hsa005000.67767099
58Protein export_Homo sapiens_hsa030600.67327860
59Lysine degradation_Homo sapiens_hsa003100.66891457
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66773369
61Hematopoietic cell lineage_Homo sapiens_hsa046400.66443945
62Small cell lung cancer_Homo sapiens_hsa052220.65445277
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65225204
64Glutathione metabolism_Homo sapiens_hsa004800.64401789
65Arginine biosynthesis_Homo sapiens_hsa002200.61134264
66Apoptosis_Homo sapiens_hsa042100.59002899
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58353907
68T cell receptor signaling pathway_Homo sapiens_hsa046600.57431834
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56587115
70Acute myeloid leukemia_Homo sapiens_hsa052210.56146984
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55819383
72Influenza A_Homo sapiens_hsa051640.55263563
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54984240
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53679465
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52660169
76Vitamin B6 metabolism_Homo sapiens_hsa007500.52558493
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52245454
78Arginine and proline metabolism_Homo sapiens_hsa003300.51221661
79Non-small cell lung cancer_Homo sapiens_hsa052230.50465366
80Propanoate metabolism_Homo sapiens_hsa006400.49963012
81Oocyte meiosis_Homo sapiens_hsa041140.49546393
82Tyrosine metabolism_Homo sapiens_hsa003500.46793807
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46779768
84N-Glycan biosynthesis_Homo sapiens_hsa005100.46567411
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.45265786
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.44756464
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44438140
88Leishmaniasis_Homo sapiens_hsa051400.42866893
89Hepatitis B_Homo sapiens_hsa051610.42293009
90Metabolic pathways_Homo sapiens_hsa011000.42130522
91Vitamin digestion and absorption_Homo sapiens_hsa049770.41239126
92Viral myocarditis_Homo sapiens_hsa054160.40969480
93Fructose and mannose metabolism_Homo sapiens_hsa000510.39744359
94Notch signaling pathway_Homo sapiens_hsa043300.39533393
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39381775
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38267465
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37996754
98Shigellosis_Homo sapiens_hsa051310.36942009
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35845672
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35721929
101MicroRNAs in cancer_Homo sapiens_hsa052060.35101211
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34701855
103Renin-angiotensin system_Homo sapiens_hsa046140.34568886
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34562897
105Pancreatic cancer_Homo sapiens_hsa052120.34489311
106Fatty acid degradation_Homo sapiens_hsa000710.33610011
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.33572326
108Toxoplasmosis_Homo sapiens_hsa051450.33382278
109Galactose metabolism_Homo sapiens_hsa000520.33369193
110Peroxisome_Homo sapiens_hsa041460.33215001
111Linoleic acid metabolism_Homo sapiens_hsa005910.32319387
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32047033
113Platelet activation_Homo sapiens_hsa046110.31183341
114Retinol metabolism_Homo sapiens_hsa008300.28751265
115Chronic myeloid leukemia_Homo sapiens_hsa052200.28715668
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.28309546
117Sulfur metabolism_Homo sapiens_hsa009200.27491021
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25906100
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25577682
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25558574
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.24547066
122Fat digestion and absorption_Homo sapiens_hsa049750.24512969
123Osteoclast differentiation_Homo sapiens_hsa043800.23643693
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22558708
125HIF-1 signaling pathway_Homo sapiens_hsa040660.22135872
126Chemical carcinogenesis_Homo sapiens_hsa052040.21821417
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21629491
128Fatty acid biosynthesis_Homo sapiens_hsa000610.20560641

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