CHD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic process involved in female pregnancy (GO:0060136)4.95576088
2establishment of protein localization to Golgi (GO:0072600)4.27284660
3monoubiquitinated protein deubiquitination (GO:0035520)4.22400156
4interkinetic nuclear migration (GO:0022027)4.08999521
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.05029874
6histone H3-K9 modification (GO:0061647)3.98046531
7positive regulation of gamma-delta T cell activation (GO:0046645)3.91227098
8histone H3-K4 trimethylation (GO:0080182)3.90223504
9protein targeting to Golgi (GO:0000042)3.85986811
10retrograde transport, vesicle recycling within Golgi (GO:0000301)3.84556578
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79394339
12negative regulation of cell killing (GO:0031342)3.79394339
13histone H3-K9 methylation (GO:0051567)3.70956360
14replication fork processing (GO:0031297)3.67954535
15regulation of histone H3-K27 methylation (GO:0061085)3.66413740
16histone H3-K4 methylation (GO:0051568)3.65907106
17interferon-gamma production (GO:0032609)3.65850199
18cellular response to ethanol (GO:0071361)3.64837542
19embryonic placenta development (GO:0001892)3.58618290
20positive regulation of protein homooligomerization (GO:0032464)3.51361165
21pre-miRNA processing (GO:0031054)3.48465442
22regulation of integrin activation (GO:0033623)3.46001774
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45817708
24negative regulation of translation, ncRNA-mediated (GO:0040033)3.45817708
25regulation of translation, ncRNA-mediated (GO:0045974)3.45817708
26positive regulation of granulocyte differentiation (GO:0030854)3.44480333
27protein dealkylation (GO:0008214)3.39596274
28protein demethylation (GO:0006482)3.39596274
29nuclear pore complex assembly (GO:0051292)3.39000722
30regulation of gamma-delta T cell differentiation (GO:0045586)3.29820061
31protein K11-linked deubiquitination (GO:0035871)3.29219950
32peptidyl-lysine methylation (GO:0018022)3.23307801
33positive regulation of histone deacetylation (GO:0031065)3.21546945
34protein K48-linked deubiquitination (GO:0071108)3.21385817
35regulation of gamma-delta T cell activation (GO:0046643)3.21288957
36histone H4-K12 acetylation (GO:0043983)3.17746985
37positive regulation by host of viral transcription (GO:0043923)3.13081253
38activated T cell proliferation (GO:0050798)3.12063565
39positive thymic T cell selection (GO:0045059)3.09747896
40trophectodermal cell differentiation (GO:0001829)3.08711529
41cellular response to zinc ion (GO:0071294)3.06678260
42tolerance induction (GO:0002507)3.06526317
43B cell receptor signaling pathway (GO:0050853)3.03696026
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02083158
45cytoplasmic mRNA processing body assembly (GO:0033962)3.00614076
46response to muramyl dipeptide (GO:0032495)3.00333991
47regulation of RNA export from nucleus (GO:0046831)2.96662677
48embryonic eye morphogenesis (GO:0048048)2.94876996
49regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.94528874
50regulation of protein polyubiquitination (GO:1902914)2.93864440
51positive T cell selection (GO:0043368)2.93616025
52transcription from mitochondrial promoter (GO:0006390)2.89490707
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86270262
54histone H3-K36 demethylation (GO:0070544)2.84887388
55histone H4-K5 acetylation (GO:0043981)2.84843108
56histone H4-K8 acetylation (GO:0043982)2.84843108
57determination of adult lifespan (GO:0008340)2.82912060
58mitotic sister chromatid cohesion (GO:0007064)2.82355119
59negative T cell selection (GO:0043383)2.82041039
60regulation of B cell receptor signaling pathway (GO:0050855)2.81142581
61histone H4-K16 acetylation (GO:0043984)2.80566687
62pore complex assembly (GO:0046931)2.79926437
63somite rostral/caudal axis specification (GO:0032525)2.78540283
64positive regulation of mRNA catabolic process (GO:0061014)2.78450364
65poly(A)+ mRNA export from nucleus (GO:0016973)2.75657382
66negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.75586837
67histone lysine methylation (GO:0034968)2.75350381
68negative regulation of histone methylation (GO:0031061)2.75308790
69positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73529261
70regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73529261
71response to interleukin-15 (GO:0070672)2.72684833
72polyketide metabolic process (GO:0030638)2.72288824
73doxorubicin metabolic process (GO:0044598)2.72288824
74daunorubicin metabolic process (GO:0044597)2.72288824
75dosage compensation (GO:0007549)2.72130243
76definitive hemopoiesis (GO:0060216)2.70028638
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.69928505
78nuclear pore organization (GO:0006999)2.69806207
79embryonic camera-type eye morphogenesis (GO:0048596)2.69796949
80negative thymic T cell selection (GO:0045060)2.68276673
81peptidyl-lysine trimethylation (GO:0018023)2.67328111
82protein localization to Golgi apparatus (GO:0034067)2.66994455
83regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.66518208
84positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.66518208
85positive regulation of developmental pigmentation (GO:0048087)2.66009963
86histone mRNA catabolic process (GO:0071044)2.65865616
87negative regulation of T cell mediated immunity (GO:0002710)2.65043352
88regulation of granulocyte differentiation (GO:0030852)2.63698802
89T cell selection (GO:0045058)2.62865726
90meiotic chromosome segregation (GO:0045132)2.61001081
91regulation of pigment cell differentiation (GO:0050932)2.59300256
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59103396
93negative regulation of T-helper cell differentiation (GO:0045623)2.59103396
94DNA strand renaturation (GO:0000733)2.58486946
95protein K63-linked deubiquitination (GO:0070536)2.58377386
96face development (GO:0060324)2.58206610
97germinal center formation (GO:0002467)2.57206073
98nucleus localization (GO:0051647)2.57025663
99histone lysine demethylation (GO:0070076)2.56290092
100DNA demethylation (GO:0080111)2.55742519
101regulation of mRNA catabolic process (GO:0061013)2.54946562
102negative regulation of cAMP-mediated signaling (GO:0043951)2.54784644
103cerebellar Purkinje cell differentiation (GO:0021702)2.54420834
104thymic T cell selection (GO:0045061)2.54360492
105pericardium development (GO:0060039)2.54206105
106regulation of interleukin-12 biosynthetic process (GO:0045075)2.53027765
107V(D)J recombination (GO:0033151)2.52905528
108alpha-beta T cell differentiation (GO:0046632)2.51536261
109NIK/NF-kappaB signaling (GO:0038061)2.51307751
110growth hormone receptor signaling pathway (GO:0060396)2.50022879
111positive regulation of CREB transcription factor activity (GO:0032793)2.48635974
112cellular extravasation (GO:0045123)2.47977263
113neural tube formation (GO:0001841)2.47611630
114B cell homeostasis (GO:0001782)2.45759291
115cellular response to interleukin-15 (GO:0071350)2.45249677
116histone H3-K9 demethylation (GO:0033169)2.45099296
117regulation of MHC class I biosynthetic process (GO:0045343)2.44751615
118negative regulation of stress fiber assembly (GO:0051497)2.44238814
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.43274161
120intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.41727890
121negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.41604686
122positive regulation of protein deacetylation (GO:0090312)2.40985733
123regulation of protein homooligomerization (GO:0032462)2.40736229
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40286906
125histone demethylation (GO:0016577)2.39665042
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39525034
127negative regulation of viral release from host cell (GO:1902187)2.39018599
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38513105
129positive regulation of protein oligomerization (GO:0032461)2.38480034
130regulation of double-strand break repair (GO:2000779)2.37822532
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37821530
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37821530
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.37821530
134T cell differentiation involved in immune response (GO:0002292)2.37810619
135alpha-beta T cell differentiation involved in immune response (GO:0002293)2.37810619
136alpha-beta T cell activation involved in immune response (GO:0002287)2.37810619
137sister chromatid segregation (GO:0000819)2.37722907
138histone methylation (GO:0016571)2.37238660
139T cell migration (GO:0072678)2.37034396
140NLS-bearing protein import into nucleus (GO:0006607)2.36751512
141embryonic hemopoiesis (GO:0035162)2.36638661
142negative regulation of neurotransmitter secretion (GO:0046929)2.35979718
143chromatin assembly (GO:0031497)2.35350528
144CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.35224778
145regulation of nucleobase-containing compound transport (GO:0032239)2.34987292
146nerve growth factor signaling pathway (GO:0038180)2.34565314
147positive regulation of gene expression, epigenetic (GO:0045815)2.34541326
148hepatocyte apoptotic process (GO:0097284)2.33428027
149RNA stabilization (GO:0043489)2.33187671
150mRNA stabilization (GO:0048255)2.33187671
151histone deubiquitination (GO:0016578)2.32404062
152negative regulation of granulocyte differentiation (GO:0030853)2.31814400
153regulation of telomere maintenance (GO:0032204)2.30644218
154hypotonic response (GO:0006971)2.30376709
155corticosteroid receptor signaling pathway (GO:0031958)2.30048451
156regulation of necroptotic process (GO:0060544)2.30043131
157T-helper cell differentiation (GO:0042093)2.29973374
158CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29973374
159retinoic acid receptor signaling pathway (GO:0048384)2.29691545
160response to UV-C (GO:0010225)2.29594778
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29174784
162snRNA transcription (GO:0009301)2.28504392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74316453
2E2F7_22180533_ChIP-Seq_HELA_Human3.90278599
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88130109
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.33922934
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.33922934
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.33922934
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.30297886
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.19352854
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03756247
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.87603013
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78693029
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.72371245
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66789551
14* MYC_22102868_ChIP-Seq_BL_Human2.64787087
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.59043091
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.46974674
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44558504
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.37270208
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.33226937
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26278759
21* TCF7_22412390_ChIP-Seq_EML_Mouse2.20603221
22VDR_21846776_ChIP-Seq_THP-1_Human2.10177326
23RUNX_20019798_ChIP-Seq_JUKART_Human2.10068472
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08586063
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07490696
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02616052
27SCL_19346495_ChIP-Seq_HPC-7_Human1.96671223
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.93839287
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93739171
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89389964
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88500628
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.84267858
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84109316
34* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.78761102
35MYB_26560356_Chip-Seq_TH1_Human1.78273501
36GATA1_22025678_ChIP-Seq_K562_Human1.72319041
37AR_21572438_ChIP-Seq_LNCaP_Human1.71935768
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70959844
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68167596
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67731935
41MAF_26560356_Chip-Seq_TH1_Human1.67591446
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65243480
43KDM2B_26808549_Chip-Seq_DND41_Human1.62704720
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61928535
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60200271
46* TP53_16413492_ChIP-PET_HCT116_Human1.58266716
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58249537
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56003976
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55852838
50EZH2_22144423_ChIP-Seq_EOC_Human1.55812928
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55206028
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55108140
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53685118
54* MYB_26560356_Chip-Seq_TH2_Human1.52670681
55* VDR_24787735_ChIP-Seq_THP-1_Human1.52303700
56* AHR_22903824_ChIP-Seq_MCF-7_Human1.48795900
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48110654
58* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46690759
59* UTX_26944678_Chip-Seq_JUKART_Human1.44581430
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43798088
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42285307
62GATA3_27048872_Chip-Seq_THYMUS_Human1.41654326
63* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37699187
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35207057
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34292421
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.34047255
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33832464
68* STAT3_23295773_ChIP-Seq_U87_Human1.33144493
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32542624
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.31209433
71* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30325335
72* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30325335
73* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29818079
74SPI1_23127762_ChIP-Seq_K562_Human1.28234952
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28011438
76DROSHA_22980978_ChIP-Seq_HELA_Human1.25207685
77* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24440213
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.23745310
79VDR_24763502_ChIP-Seq_THP-1_Human1.22462698
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21162492
81* RUNX1_22412390_ChIP-Seq_EML_Mouse1.20795574
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.19897986
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18886146
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18709769
85GATA1_19941826_ChIP-Seq_K562_Human1.17216531
86NCOR1_26117541_ChIP-Seq_K562_Human1.16120120
87* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15294396
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15138708
89ER_23166858_ChIP-Seq_MCF-7_Human1.14943422
90* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14705213
91TAF15_26573619_Chip-Seq_HEK293_Human1.14108585
92* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13642854
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13534623
94RXR_22108803_ChIP-Seq_LS180_Human1.13477943
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12965374
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12732004
97* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12113070
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11958614
99* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11816273
100TCF4_23295773_ChIP-Seq_U87_Human1.11363152
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11247482
102GATA2_19941826_ChIP-Seq_K562_Human1.10885693
103GATA3_26560356_Chip-Seq_TH2_Human1.10399145
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.09432008
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07993837
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06877744
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.06633636
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06237283
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05961819
110SMAD4_21799915_ChIP-Seq_A2780_Human1.05530799
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04282036
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04213931
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04156337
114GBX2_23144817_ChIP-Seq_PC3_Human1.03968982
115SMRT_27268052_Chip-Seq_Bcells_Human1.03605086
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.02384214
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01995430
118MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01398311
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00723767
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00582773
121* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00327492
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98696988
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98534305
124FUS_26573619_Chip-Seq_HEK293_Human0.98088740
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.97659701
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96817869
127* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96233108
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95084401
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94966551
130* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94750132
131* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94302966
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93954128
133KDM2B_26808549_Chip-Seq_K562_Human0.92038837
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.91911583
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90910688
136* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90814557
137CBP_20019798_ChIP-Seq_JUKART_Human0.89690110
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89690110
139* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89673910
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.89493041
141TP63_17297297_ChIP-ChIP_HaCaT_Human0.89051075
142* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88773670
143PU_27001747_Chip-Seq_BMDM_Mouse0.88156910
144MAF_26560356_Chip-Seq_TH2_Human0.88066498
145* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87972880
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87932380
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.87051627
148* ELK3_25401928_ChIP-Seq_HUVEC_Human0.86049348
149IRF8_21731497_ChIP-ChIP_J774_Mouse0.85735150
150* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85599767
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85574926
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85146727
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85110519
154* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84609106
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83925654
156SPI1_23547873_ChIP-Seq_NB4_Human0.83747077
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.83139811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.32193209
2MP0009278_abnormal_bone_marrow3.20593417
3MP0000569_abnormal_digit_pigmentation3.10969616
4MP0002009_preneoplasia2.84771296
5MP0003890_abnormal_embryonic-extraembry2.52248871
6MP0003763_abnormal_thymus_physiology2.36394053
7MP0010352_gastrointestinal_tract_polyps2.31434628
8MP0004264_abnormal_extraembryonic_tissu2.26653203
9MP0002166_altered_tumor_susceptibility2.15561447
10MP0005076_abnormal_cell_differentiation2.14547265
11MP0005075_abnormal_melanosome_morpholog2.10800130
12MP0000685_abnormal_immune_system2.01975216
13MP0002254_reproductive_system_inflammat2.00419456
14MP0002396_abnormal_hematopoietic_system1.96844975
15MP0005409_darkened_coat_color1.94117570
16MP0003787_abnormal_imprinting1.93835190
17MP0001800_abnormal_humoral_immune1.86708707
18MP0002006_tumorigenesis1.84686719
19MP0003656_abnormal_erythrocyte_physiolo1.83891176
20MP0001835_abnormal_antigen_presentation1.81752803
21MP0008877_abnormal_DNA_methylation1.79757274
22MP0005397_hematopoietic_system_phenotyp1.74878126
23MP0001545_abnormal_hematopoietic_system1.74878126
24MP0005174_abnormal_tail_pigmentation1.73879059
25MP0003045_fibrosis1.71305357
26MP0005310_abnormal_salivary_gland1.68169687
27MP0005671_abnormal_response_to1.67524412
28MP0001790_abnormal_immune_system1.67370747
29MP0005387_immune_system_phenotype1.67370747
30MP0004130_abnormal_muscle_cell1.65642637
31MP0003724_increased_susceptibility_to1.65318896
32MP0002138_abnormal_hepatobiliary_system1.59399511
33MP0004808_abnormal_hematopoietic_stem1.55842327
34MP0010094_abnormal_chromosome_stability1.55787028
35MP0000703_abnormal_thymus_morphology1.55492134
36* MP0002398_abnormal_bone_marrow1.54108529
37MP0003303_peritoneal_inflammation1.53338292
38MP0000371_diluted_coat_color1.47610245
39MP0008961_abnormal_basal_metabolism1.47010060
40MP0003705_abnormal_hypodermis_morpholog1.43992606
41MP0001873_stomach_inflammation1.43903203
42MP0003453_abnormal_keratinocyte_physiol1.43666040
43MP0002452_abnormal_antigen_presenting1.42913988
44MP0003300_gastrointestinal_ulcer1.42554628
45MP0001293_anophthalmia1.42312552
46MP0002086_abnormal_extraembryonic_tissu1.37511835
47MP0000383_abnormal_hair_follicle1.37212756
48MP0003646_muscle_fatigue1.34352250
49MP0002419_abnormal_innate_immunity1.33670582
50* MP0000689_abnormal_spleen_morphology1.30496625
51MP0000490_abnormal_crypts_of1.30417885
52MP0002420_abnormal_adaptive_immunity1.29897916
53MP0001819_abnormal_immune_cell1.29001485
54* MP0002405_respiratory_system_inflammati1.28555285
55MP0003866_abnormal_defecation1.28180953
56MP0004883_abnormal_blood_vessel1.27464784
57* MP0002722_abnormal_immune_system1.26674578
58MP0006292_abnormal_olfactory_placode1.26376618
59* MP0000716_abnormal_immune_system1.26175488
60MP0010155_abnormal_intestine_physiology1.25798468
61MP0002723_abnormal_immune_serum1.25200561
62MP0001672_abnormal_embryogenesis/_devel1.24907505
63MP0005380_embryogenesis_phenotype1.24907505
64MP0000015_abnormal_ear_pigmentation1.24754835
65MP0005171_absent_coat_pigmentation1.24045455
66MP0003121_genomic_imprinting1.19830263
67MP0006082_CNS_inflammation1.19260575
68MP0002088_abnormal_embryonic_growth/wei1.17028530
69MP0001502_abnormal_circadian_rhythm1.15760771
70MP0003984_embryonic_growth_retardation1.15672023
71MP0010030_abnormal_orbit_morphology1.15639337
72MP0001348_abnormal_lacrimal_gland1.13809529
73MP0001851_eye_inflammation1.13084540
74MP0000350_abnormal_cell_proliferation1.12159346
75MP0010307_abnormal_tumor_latency1.11834737
76MP0004043_abnormal_pH_regulation1.11448575
77MP0003935_abnormal_craniofacial_develop1.10583285
78MP0002925_abnormal_cardiovascular_devel1.09447512
79MP0003183_abnormal_peptide_metabolism1.08859083
80MP0001879_abnormal_lymphatic_vessel1.08827158
81MP0005000_abnormal_immune_tolerance1.08546262
82MP0002933_joint_inflammation1.08382470
83MP0008007_abnormal_cellular_replicative1.04834431
84MP0000432_abnormal_head_morphology1.04165589
85* MP0002429_abnormal_blood_cell1.03921293
86* MP0003077_abnormal_cell_cycle1.03916560
87MP0002084_abnormal_developmental_patter1.03053962
88MP0003111_abnormal_nucleus_morphology1.02269113
89* MP0004197_abnormal_fetal_growth/weight/1.01458021
90MP0002277_abnormal_respiratory_mucosa1.00911853
91MP0002075_abnormal_coat/hair_pigmentati0.99578168
92MP0003172_abnormal_lysosome_physiology0.99340480
93MP0003566_abnormal_cell_adhesion0.97191745
94MP0004947_skin_inflammation0.96201766
95MP0003448_altered_tumor_morphology0.94217437
96MP0002877_abnormal_melanocyte_morpholog0.92940393
97MP0000427_abnormal_hair_cycle0.92907673
98MP0010678_abnormal_skin_adnexa0.92643794
99MP0002085_abnormal_embryonic_tissue0.92300976
100MP0002998_abnormal_bone_remodeling0.91653146
101MP0003091_abnormal_cell_migration0.90986741
102MP0005645_abnormal_hypothalamus_physiol0.90695562
103MP0002092_abnormal_eye_morphology0.89796771
104MP0004510_myositis0.89581698
105MP0008260_abnormal_autophagy0.88893008
106MP0005023_abnormal_wound_healing0.88488611
107MP0004142_abnormal_muscle_tone0.87057442
108MP0004381_abnormal_hair_follicle0.84631727
109MP0002332_abnormal_exercise_endurance0.84496454
110MP0003943_abnormal_hepatobiliary_system0.83882088
111MP0001501_abnormal_sleep_pattern0.82646001
112MP0002168_other_aberrant_phenotype0.81813215
113MP0005025_abnormal_response_to0.81794107
114MP0003119_abnormal_digestive_system0.80780141
115MP0005083_abnormal_biliary_tract0.80511724
116MP0009333_abnormal_splenocyte_physiolog0.80256968
117* MP0002019_abnormal_tumor_incidence0.80216474
118MP0001697_abnormal_embryo_size0.78047215
119MP0003941_abnormal_skin_development0.77770440
120MP0009115_abnormal_fat_cell0.76516038
121MP0004484_altered_response_of0.75990128
122MP0005375_adipose_tissue_phenotype0.75603551
123MP0008995_early_reproductive_senescence0.75598778
124MP0002932_abnormal_joint_morphology0.74645394
125MP0003567_abnormal_fetal_cardiomyocyte0.74406502
126MP0003690_abnormal_glial_cell0.73590065
127MP0002132_abnormal_respiratory_system0.73352462
128MP0002116_abnormal_craniofacial_bone0.72973444
129MP0001186_pigmentation_phenotype0.72520619
130* MP0009703_decreased_birth_body0.72244616
131MP0002638_abnormal_pupillary_reflex0.72051868
132MP0003436_decreased_susceptibility_to0.71242001
133MP0000733_abnormal_muscle_development0.70623134
134* MP0001784_abnormal_fluid_regulation0.70375112
135* MP0001845_abnormal_inflammatory_respons0.67019967
136MP0009785_altered_susceptibility_to0.66835115
137MP0005164_abnormal_response_to0.66162164
138MP0000003_abnormal_adipose_tissue0.65381701
139MP0001440_abnormal_grooming_behavior0.64055163
140MP0001188_hyperpigmentation0.63338322
141MP0000470_abnormal_stomach_morphology0.63073131
142* MP0002928_abnormal_bile_duct0.60667352
143MP0005666_abnormal_adipose_tissue0.58741258
144MP0002095_abnormal_skin_pigmentation0.57814607
145MP0009764_decreased_sensitivity_to0.57775244
146MP0005167_abnormal_blood-brain_barrier0.57391138

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)4.36938566
2Genetic anticipation (HP:0003743)4.00566771
3Volvulus (HP:0002580)3.93325384
4Rib fusion (HP:0000902)3.89587105
5Intestinal fistula (HP:0100819)3.87752320
6Abnormality of the fingertips (HP:0001211)3.80770917
7Rectovaginal fistula (HP:0000143)3.23370282
8Rectal fistula (HP:0100590)3.23370282
9Progressive cerebellar ataxia (HP:0002073)2.89361921
10Lip pit (HP:0100267)2.75367663
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71166914
12Vaginal fistula (HP:0004320)2.70880571
13Pustule (HP:0200039)2.68104328
14Chronic hepatic failure (HP:0100626)2.67381522
15Neoplasm of the tracheobronchial system (HP:0100552)2.66642180
16Hyperkalemia (HP:0002153)2.59798650
17Widely spaced teeth (HP:0000687)2.59792324
18Chromsome breakage (HP:0040012)2.59525363
19IgA deficiency (HP:0002720)2.55273781
20Stomach cancer (HP:0012126)2.52107356
21Protruding tongue (HP:0010808)2.46729352
22Colitis (HP:0002583)2.46669809
23Abnormality of the nasal septum (HP:0000419)2.45925682
24Increased IgM level (HP:0003496)2.44480630
25T lymphocytopenia (HP:0005403)2.42698691
26Ulnar bowing (HP:0003031)2.42363687
27Eczematoid dermatitis (HP:0000976)2.39781512
28Macroorchidism (HP:0000053)2.35420110
29Gastrointestinal infarctions (HP:0005244)2.34426718
30Papillary thyroid carcinoma (HP:0002895)2.33028602
31Acute myeloid leukemia (HP:0004808)2.31778965
32Fair hair (HP:0002286)2.30138719
33Abnormality of T cell number (HP:0011839)2.29366153
34Hyperventilation (HP:0002883)2.28944972
35Astrocytoma (HP:0009592)2.27434636
36Abnormality of the astrocytes (HP:0100707)2.27434636
37Hypoplasia of the thymus (HP:0000778)2.26877688
38Supernumerary ribs (HP:0005815)2.26310896
39Neonatal hypoglycemia (HP:0001998)2.25508732
40Urethral obstruction (HP:0000796)2.24650298
41Nephroblastoma (Wilms tumor) (HP:0002667)2.21751133
42Alveolar cell carcinoma (HP:0006519)2.21696295
43Recurrent cutaneous fungal infections (HP:0011370)2.21451907
44Chronic mucocutaneous candidiasis (HP:0002728)2.21451907
45Hypochromic anemia (HP:0001931)2.21143105
46Cerebral aneurysm (HP:0004944)2.20651969
47Ependymoma (HP:0002888)2.18505370
48Combined immunodeficiency (HP:0005387)2.18056451
49Recurrent fungal infections (HP:0002841)2.16976973
50Bilateral microphthalmos (HP:0007633)2.15980497
51Long eyelashes (HP:0000527)2.15869134
52Abnormality of incisor morphology (HP:0011063)2.14943386
53Clumsiness (HP:0002312)2.14407752
54Tented upper lip vermilion (HP:0010804)2.14374403
55Absent frontal sinuses (HP:0002688)2.12431869
56Anal stenosis (HP:0002025)2.09629411
57Prominent nose (HP:0000448)2.09554199
58Papilledema (HP:0001085)2.09256156
59Thyroiditis (HP:0100646)2.07474919
60Hepatoblastoma (HP:0002884)2.07413300
61Gaze-evoked nystagmus (HP:0000640)2.07054455
62Abnormal hair whorl (HP:0010721)2.06531540
63Recurrent bronchitis (HP:0002837)2.06449808
64Hypoplastic iliac wings (HP:0002866)2.04927503
65Intestinal atresia (HP:0011100)2.04604174
66Cheilitis (HP:0100825)2.04558038
67Optic neuritis (HP:0100653)2.02270317
68Retrobulbar optic neuritis (HP:0100654)2.02270317
69Chronic diarrhea (HP:0002028)2.02238975
70Embryonal renal neoplasm (HP:0011794)2.01694915
71Slow saccadic eye movements (HP:0000514)2.00404373
72Recurrent viral infections (HP:0004429)1.99710406
73Dysmetric saccades (HP:0000641)1.99678694
74Generalized hypopigmentation of hair (HP:0011358)1.99339183
75Heterotopia (HP:0002282)1.98737488
76Tapered finger (HP:0001182)1.97343987
77Recurrent bacterial skin infections (HP:0005406)1.96804653
78Neoplasm of the oral cavity (HP:0100649)1.96418043
79Alopecia of scalp (HP:0002293)1.95997424
80Short 5th finger (HP:0009237)1.94316252
81Acute lymphatic leukemia (HP:0006721)1.94095504
82Leukocytosis (HP:0001974)1.93217120
83Supernumerary bones of the axial skeleton (HP:0009144)1.92556179
84Sandal gap (HP:0001852)1.91783533
85Neoplasm of striated muscle (HP:0009728)1.91141949
86Inflammation of the large intestine (HP:0002037)1.90809192
87Depressed nasal tip (HP:0000437)1.90770754
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.89986161
89Ectopic kidney (HP:0000086)1.89571960
90Short humerus (HP:0005792)1.89208668
91Glioma (HP:0009733)1.88736993
92Postural instability (HP:0002172)1.87106904
93Autoimmune thrombocytopenia (HP:0001973)1.86415003
94Abnormality of the ileum (HP:0001549)1.86131734
95Mediastinal lymphadenopathy (HP:0100721)1.85859166
96Absent speech (HP:0001344)1.85663572
97Broad thumb (HP:0011304)1.84724281
98Subacute progressive viral hepatitis (HP:0006572)1.83563137
99Poor coordination (HP:0002370)1.83084847
100Eosinophilia (HP:0001880)1.82186883
101Viral hepatitis (HP:0006562)1.81816079
102Hypotelorism (HP:0000601)1.80223375
103Abnormality of eosinophils (HP:0001879)1.80098388
104Large earlobe (HP:0009748)1.79613024
105Skin tags (HP:0010609)1.78774566
106Obstructive sleep apnea (HP:0002870)1.78213293
107Narrow palate (HP:0000189)1.78117270
108Hypoplastic labia majora (HP:0000059)1.77604499
109Hypoplastic ischia (HP:0003175)1.77518678
110Curly hair (HP:0002212)1.76952160
111Abnormality of the renal cortex (HP:0011035)1.76646170
112Pancreatic islet-cell hyperplasia (HP:0004510)1.76600703
113Myelodysplasia (HP:0002863)1.75440207
114Rhabdomyosarcoma (HP:0002859)1.75080705
115Basal cell carcinoma (HP:0002671)1.74881221
116Vertebral fusion (HP:0002948)1.74298724
117Spinal muscular atrophy (HP:0007269)1.73130428
118Blue irides (HP:0000635)1.73031985
119Thick eyebrow (HP:0000574)1.72436382
120Poikiloderma (HP:0001029)1.72002409
121Gastrointestinal inflammation (HP:0004386)1.71768925
122Abnormality of the radial head (HP:0003995)1.71559110
123Increased number of teeth (HP:0011069)1.71423882
124Panhypogammaglobulinemia (HP:0003139)1.71380631
125Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70785106
126Myositis (HP:0100614)1.70710666
127Autoimmune hemolytic anemia (HP:0001890)1.70259367
128Deep palmar crease (HP:0006191)1.69765057
129Abnormality of chromosome segregation (HP:0002916)1.69644342
130Stomatitis (HP:0010280)1.69245623
131Orchitis (HP:0100796)1.68915695
132Abnormality of the columella (HP:0009929)1.68573594
133Agammaglobulinemia (HP:0004432)1.68401149
134Vasculitis (HP:0002633)1.67859238
135Abnormality of the lower motor neuron (HP:0002366)1.67764454
136Syringomyelia (HP:0003396)1.67321238
137Spinal cord lesions (HP:0100561)1.67321238
138Dislocated radial head (HP:0003083)1.66443444
139Trigonocephaly (HP:0000243)1.65883670
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65190446
141Submucous cleft hard palate (HP:0000176)1.65139482
142Broad palm (HP:0001169)1.65033186
143Abnormality of the ischium (HP:0003174)1.64869217
144Severe combined immunodeficiency (HP:0004430)1.64567401
145Abnormality of T cells (HP:0002843)1.64461393
146Spontaneous hematomas (HP:0007420)1.63864518
147Concave nail (HP:0001598)1.62141206
148Germ cell neoplasia (HP:0100728)1.61608038
149Abnormal number of incisors (HP:0011064)1.61180382
150Gingivitis (HP:0000230)1.60926302
151Granulocytopenia (HP:0001913)1.60851727
152Elevated erythrocyte sedimentation rate (HP:0003565)1.60784014
153Overgrowth (HP:0001548)1.60767660
154Preauricular skin tag (HP:0000384)1.60537871
155Aplasia/hypoplasia of the humerus (HP:0006507)1.60473585
156Meningitis (HP:0001287)1.60471500
157Low anterior hairline (HP:0000294)1.60069061
158Abnormal delayed hypersensitivity skin test (HP:0002963)1.58956677
159Abnormality of the labia majora (HP:0012881)1.57165112
160Truncal obesity (HP:0001956)1.57038743
161Coarse hair (HP:0002208)1.57009335
162Thin upper lip vermilion (HP:0000219)1.56458296
163Uterine leiomyosarcoma (HP:0002891)1.55165154
164Leiomyosarcoma (HP:0100243)1.55165154
165Somatic mutation (HP:0001428)1.54099596
166Hematochezia (HP:0002573)1.53362482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.45840796
2ICK2.94937756
3FRK2.57057714
4MAPK152.24914449
5MAP4K12.07072526
6TXK1.98846467
7STK101.96769855
8CSK1.93053747
9GRK61.87639040
10MAP3K61.80872516
11MATK1.79080469
12MAP3K101.77386360
13DDR21.74668090
14TGFBR21.74329777
15BRD41.66050747
16PRKD21.61582225
17TYRO31.60964585
18MAP3K141.58697033
19RIPK41.56289228
20CAMK1D1.54312153
21SIK21.53717896
22FGFR31.53412751
23YES11.50698539
24HIPK21.49818768
25MAPK71.49471195
26CSF1R1.48984243
27PIM11.44800216
28CHUK1.40971504
29CAMK1G1.40079712
30CDK61.39287425
31EPHA31.37691690
32SGK4941.34433755
33SGK2231.34433755
34TYK21.32123136
35JAK11.28214279
36IKBKB1.27102117
37PDGFRA1.26396696
38ITK1.25919110
39MKNK21.21913795
40BLK1.21552855
41GRK11.18428645
42TEC1.17832088
43DYRK1B1.17438046
44AKT31.16785750
45MARK21.16535011
46CAMKK21.14044202
47NLK1.13883098
48PRPF4B1.13748249
49ACVR1B1.12985780
50JAK31.11296041
51TRPM71.10881293
52RIPK11.10271735
53IRAK11.04745236
54CDK71.04697455
55CAMK41.01969544
56SIK11.01892332
57BMX0.99007974
58MTOR0.98516980
59WNK10.95938419
60MAP3K20.94470745
61CHEK20.91633379
62TNIK0.91499636
63MAP3K130.90577945
64FGR0.90145531
65STK240.89548101
66NEK60.88305761
67FES0.87044647
68ERN10.85409501
69FGFR20.84155439
70CAMKK10.82929158
71HCK0.82556997
72PDGFRB0.81848369
73INSRR0.80486461
74MAP3K70.79555011
75EEF2K0.78048888
76LCK0.77942127
77MARK30.75944682
78SGK30.75453460
79RPS6KC10.75220171
80RPS6KL10.75220171
81SIK30.75095282
82RPS6KA60.73265743
83PIK3CG0.72953599
84CDC42BPA0.72502849
85RET0.72320364
86STK110.72230268
87PRKAA20.71562773
88CAMK10.70963142
89PIK3CA0.70515852
90LATS10.70259087
91ATR0.69993108
92GSK3A0.69983617
93IKBKE0.69150068
94DYRK1A0.68783312
95NEK20.68584397
96MELK0.68289930
97PDK10.68276745
98MAP2K30.66753544
99STK40.66590531
100GRK70.66060805
101CDK90.65448776
102PNCK0.65145918
103ATM0.65085330
104MAPK110.63917461
105TAOK30.62887604
106PAK30.62125659
107FGFR40.61989862
108KSR10.61710330
109GRK50.61582838
110ERBB20.61454311
111CHEK10.60956221
112BMPR20.60440073
113PRKCQ0.59393254
114STK380.58689137
115IRAK40.57980597
116WNK40.57700129
117ALK0.56451007
118BMPR1B0.53753472
119MAPK10.53026033
120PRKAA10.52950105
121PKN20.52037648
122ZAP700.50479897
123MAPK140.49920258
124MAPK120.49714739
125BRSK20.48925660
126CDK20.48566137
127LYN0.47850189
128JAK20.47789763
129SGK20.47140571
130PTK2B0.46545866
131SGK10.46504383
132BTK0.46252307
133CDK40.45392693
134TNK20.45224375
135KIT0.45062322
136ADRBK20.44102372
137INSR0.44027454
138SYK0.42532010
139DMPK0.42462536
140FLT30.41990850
141PTK60.41289827
142MAPK30.41274880

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.72191549
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.01946324
3Transcriptional misregulation in cancer_Homo sapiens_hsa052021.89743890
4Lysine degradation_Homo sapiens_hsa003101.86504672
5B cell receptor signaling pathway_Homo sapiens_hsa046621.81079791
6mTOR signaling pathway_Homo sapiens_hsa041501.75929946
7Notch signaling pathway_Homo sapiens_hsa043301.68600252
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58915717
9T cell receptor signaling pathway_Homo sapiens_hsa046601.55994594
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.55821349
11Adherens junction_Homo sapiens_hsa045201.55151861
12Measles_Homo sapiens_hsa051621.50483785
13MicroRNAs in cancer_Homo sapiens_hsa052061.47634964
14Fanconi anemia pathway_Homo sapiens_hsa034601.43996000
15Chronic myeloid leukemia_Homo sapiens_hsa052201.41048130
16Acute myeloid leukemia_Homo sapiens_hsa052211.40462999
17mRNA surveillance pathway_Homo sapiens_hsa030151.38891512
18Osteoclast differentiation_Homo sapiens_hsa043801.37234432
19Fatty acid biosynthesis_Homo sapiens_hsa000611.32868392
20Herpes simplex infection_Homo sapiens_hsa051681.31078142
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.29319124
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28837870
23Renal cell carcinoma_Homo sapiens_hsa052111.28099917
24Hematopoietic cell lineage_Homo sapiens_hsa046401.27830509
25Base excision repair_Homo sapiens_hsa034101.24256990
26Small cell lung cancer_Homo sapiens_hsa052221.22097937
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19335914
28Colorectal cancer_Homo sapiens_hsa052101.16892678
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15883353
30Pancreatic cancer_Homo sapiens_hsa052121.11660539
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11266091
32Leishmaniasis_Homo sapiens_hsa051401.10632442
33Basal cell carcinoma_Homo sapiens_hsa052171.07811336
34Hepatitis B_Homo sapiens_hsa051611.07556405
35Viral myocarditis_Homo sapiens_hsa054161.06587843
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06444647
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06246765
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04756895
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04409782
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02260878
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00906281
42TNF signaling pathway_Homo sapiens_hsa046681.00622525
43Mismatch repair_Homo sapiens_hsa034300.99459608
44Circadian rhythm_Homo sapiens_hsa047100.99422846
45HTLV-I infection_Homo sapiens_hsa051660.98770247
46p53 signaling pathway_Homo sapiens_hsa041150.98015501
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96674364
48Influenza A_Homo sapiens_hsa051640.96326964
49Autoimmune thyroid disease_Homo sapiens_hsa053200.96056296
50Toxoplasmosis_Homo sapiens_hsa051450.95694379
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95301390
52Non-homologous end-joining_Homo sapiens_hsa034500.94097392
53Long-term potentiation_Homo sapiens_hsa047200.93848443
54Apoptosis_Homo sapiens_hsa042100.92708183
55Prostate cancer_Homo sapiens_hsa052150.92662630
56Chemokine signaling pathway_Homo sapiens_hsa040620.91334915
57Viral carcinogenesis_Homo sapiens_hsa052030.90888383
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89876485
59Wnt signaling pathway_Homo sapiens_hsa043100.88983541
60Proteoglycans in cancer_Homo sapiens_hsa052050.88930432
61Hippo signaling pathway_Homo sapiens_hsa043900.88878020
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87640922
63Dorso-ventral axis formation_Homo sapiens_hsa043200.87570739
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87471723
65Endometrial cancer_Homo sapiens_hsa052130.87038262
66GnRH signaling pathway_Homo sapiens_hsa049120.86383568
67Non-small cell lung cancer_Homo sapiens_hsa052230.85780893
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.85538295
69Pathways in cancer_Homo sapiens_hsa052000.84876507
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.84520667
71Allograft rejection_Homo sapiens_hsa053300.84506211
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.83090868
73TGF-beta signaling pathway_Homo sapiens_hsa043500.83009599
74Inositol phosphate metabolism_Homo sapiens_hsa005620.82993653
75ABC transporters_Homo sapiens_hsa020100.82905373
76Choline metabolism in cancer_Homo sapiens_hsa052310.82159241
77Estrogen signaling pathway_Homo sapiens_hsa049150.80105510
78Antigen processing and presentation_Homo sapiens_hsa046120.78854304
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77901310
80Glioma_Homo sapiens_hsa052140.77351526
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77160445
82Cholinergic synapse_Homo sapiens_hsa047250.77131379
83MAPK signaling pathway_Homo sapiens_hsa040100.76627532
84Staphylococcus aureus infection_Homo sapiens_hsa051500.76300996
85FoxO signaling pathway_Homo sapiens_hsa040680.75790968
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74856275
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73034653
88Oxytocin signaling pathway_Homo sapiens_hsa049210.72864490
89Prolactin signaling pathway_Homo sapiens_hsa049170.71660665
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71573389
91Graft-versus-host disease_Homo sapiens_hsa053320.70327773
92Hedgehog signaling pathway_Homo sapiens_hsa043400.69667542
93Platelet activation_Homo sapiens_hsa046110.69347205
94Long-term depression_Homo sapiens_hsa047300.69137928
95Type I diabetes mellitus_Homo sapiens_hsa049400.68915931
96Insulin resistance_Homo sapiens_hsa049310.68702183
97African trypanosomiasis_Homo sapiens_hsa051430.67881284
98Hepatitis C_Homo sapiens_hsa051600.67795803
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.67617517
100ErbB signaling pathway_Homo sapiens_hsa040120.66565992
101Focal adhesion_Homo sapiens_hsa045100.65864475
102cAMP signaling pathway_Homo sapiens_hsa040240.65101861
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64099261
104HIF-1 signaling pathway_Homo sapiens_hsa040660.63444248
105Cell cycle_Homo sapiens_hsa041100.62702753
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.62513126
107Rap1 signaling pathway_Homo sapiens_hsa040150.62041206
108Thyroid cancer_Homo sapiens_hsa052160.61872105
109Shigellosis_Homo sapiens_hsa051310.61114763
110Ras signaling pathway_Homo sapiens_hsa040140.61035036
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60268211
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.58750273
113VEGF signaling pathway_Homo sapiens_hsa043700.58597607
114Type II diabetes mellitus_Homo sapiens_hsa049300.58362492
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58324822
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56099085
117Tuberculosis_Homo sapiens_hsa051520.54582534
118Renin secretion_Homo sapiens_hsa049240.54548213
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53850553
120Insulin signaling pathway_Homo sapiens_hsa049100.53637312
121Regulation of autophagy_Homo sapiens_hsa041400.53553949
122AMPK signaling pathway_Homo sapiens_hsa041520.53307759
123Legionellosis_Homo sapiens_hsa051340.52771030
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52208355
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50099872
126Malaria_Homo sapiens_hsa051440.49924990
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49436528
128RNA degradation_Homo sapiens_hsa030180.49122763
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48894885
130Amphetamine addiction_Homo sapiens_hsa050310.48861065

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