CHD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.01454295
2synaptic vesicle maturation (GO:0016188)6.01125509
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59359023
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23559252
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16829323
6layer formation in cerebral cortex (GO:0021819)5.09387214
7vocalization behavior (GO:0071625)4.88403603
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.76198664
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75578654
10regulation of glutamate receptor signaling pathway (GO:1900449)4.56790823
11glutamate secretion (GO:0014047)4.48747679
12exploration behavior (GO:0035640)4.48522681
13dendritic spine morphogenesis (GO:0060997)4.37030258
14negative regulation of erythrocyte differentiation (GO:0045647)4.34047044
15synaptic vesicle exocytosis (GO:0016079)4.31355691
16regulation of synaptic vesicle exocytosis (GO:2000300)4.28774248
17regulation of neuronal synaptic plasticity (GO:0048168)4.18253162
18regulation of synapse structural plasticity (GO:0051823)4.18045828
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06488071
20protein localization to synapse (GO:0035418)4.03706949
21neurotransmitter secretion (GO:0007269)3.92174629
22proline transport (GO:0015824)3.87382601
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.83686761
24activation of protein kinase A activity (GO:0034199)3.76836618
25regulation of synaptic vesicle transport (GO:1902803)3.75102499
26sodium ion export (GO:0071436)3.72440654
27dendrite morphogenesis (GO:0048813)3.69901087
28regulation of ARF protein signal transduction (GO:0032012)3.56734881
29regulation of dendritic spine morphogenesis (GO:0061001)3.53927608
30neuromuscular process controlling balance (GO:0050885)3.53732602
31thymic T cell selection (GO:0045061)3.51935284
32neurotransmitter-gated ion channel clustering (GO:0072578)3.44713964
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44602740
34gamma-aminobutyric acid transport (GO:0015812)3.43139424
35cellular potassium ion homeostasis (GO:0030007)3.42286482
36positive regulation of synapse maturation (GO:0090129)3.41252419
37long-term memory (GO:0007616)3.40722888
38neuron cell-cell adhesion (GO:0007158)3.34014378
39regulation of histone H3-K27 methylation (GO:0061085)3.32666821
40positive regulation of membrane potential (GO:0045838)3.32513956
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28820354
42neuron recognition (GO:0008038)3.26874801
43synaptic transmission, glutamatergic (GO:0035249)3.26287749
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25994590
45establishment of nucleus localization (GO:0040023)3.24726328
46axonal fasciculation (GO:0007413)3.23367403
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.23147656
48mannose metabolic process (GO:0006013)3.23147177
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.20413985
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19014323
51cell migration in hindbrain (GO:0021535)3.18473562
52positive thymic T cell selection (GO:0045059)3.18453799
53regulation of NFAT protein import into nucleus (GO:0051532)3.18437050
54negative thymic T cell selection (GO:0045060)3.13801011
55regulation of synaptic plasticity (GO:0048167)3.13528364
56glutamate receptor signaling pathway (GO:0007215)3.13041471
57response to laminar fluid shear stress (GO:0034616)3.12588834
58cell communication by electrical coupling (GO:0010644)3.07349007
59T cell selection (GO:0045058)3.06121234
60dendritic spine organization (GO:0097061)3.05381621
61auditory behavior (GO:0031223)3.03702589
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03411267
63prepulse inhibition (GO:0060134)3.03240508
64histone H3-K36 demethylation (GO:0070544)3.02181764
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00805021
66negative T cell selection (GO:0043383)3.00481380
67positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99718083
68regulation of postsynaptic membrane potential (GO:0060078)2.98241167
69vesicle transport along microtubule (GO:0047496)2.97410943
70cerebellar Purkinje cell layer development (GO:0021680)2.97331997
71positive T cell selection (GO:0043368)2.96997756
72positive regulation of gamma-delta T cell activation (GO:0046645)2.96461545
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95427643
74clathrin coat assembly (GO:0048268)2.94323606
75central nervous system projection neuron axonogenesis (GO:0021952)2.94252639
76protein localization to endosome (GO:0036010)2.93042260
77neurotransmitter transport (GO:0006836)2.92833037
78cerebellar Purkinje cell differentiation (GO:0021702)2.91520093
79neuron-neuron synaptic transmission (GO:0007270)2.90571791
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.90448969
81regulation of clathrin-mediated endocytosis (GO:2000369)2.89291055
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88669379
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87985572
84regulation of dendritic spine development (GO:0060998)2.87226069
85positive regulation of dendritic spine development (GO:0060999)2.85460685
86glycine transport (GO:0015816)2.84419450
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83925113
88positive regulation of fibroblast migration (GO:0010763)2.83912472
89synaptic vesicle endocytosis (GO:0048488)2.82034786
90dopamine receptor signaling pathway (GO:0007212)2.80955312
91neuronal ion channel clustering (GO:0045161)2.80659248
92neuronal action potential propagation (GO:0019227)2.77178572
93semaphorin-plexin signaling pathway (GO:0071526)2.75938661
94regulation of neurotransmitter levels (GO:0001505)2.75425826
95signal complex assembly (GO:0007172)2.75305182
96nerve growth factor signaling pathway (GO:0038180)2.75235195
97regulation of ARF GTPase activity (GO:0032312)2.74005060
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73345910
99endothelial cell chemotaxis (GO:0035767)2.73001270
100response to auditory stimulus (GO:0010996)2.71718140
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.71209407
102regulation of female receptivity (GO:0045924)2.71158091
103adherens junction assembly (GO:0034333)2.70554196
104innervation (GO:0060384)2.70543706
105transmission of nerve impulse (GO:0019226)2.70018665
106histone H3-K9 demethylation (GO:0033169)2.69903329
107glial cell proliferation (GO:0014009)2.68799661
108regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67934734
109histone H3-K4 trimethylation (GO:0080182)2.67781949
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66856822
111positive regulation of histone deacetylation (GO:0031065)2.66207415
112alanine transport (GO:0032328)2.66134647
113cellular sodium ion homeostasis (GO:0006883)2.66081368
114social behavior (GO:0035176)2.65981457
115intraspecies interaction between organisms (GO:0051703)2.65981457
116regulation of neurotransmitter secretion (GO:0046928)2.65942696
117negative regulation of cell size (GO:0045792)2.65436490
118response to muramyl dipeptide (GO:0032495)2.64764769
119regulation of extracellular matrix disassembly (GO:0010715)2.64187047
120long-term synaptic potentiation (GO:0060291)2.64128506
121cell-substrate adherens junction assembly (GO:0007045)2.63737320
122focal adhesion assembly (GO:0048041)2.63737320
123histone lysine demethylation (GO:0070076)2.63155807
124postsynaptic membrane organization (GO:0001941)2.62104788
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61865511
126neuromuscular process (GO:0050905)2.60849134
127organelle transport along microtubule (GO:0072384)2.60655240
128regulation of vesicle fusion (GO:0031338)2.59912492
129regulation of gamma-delta T cell differentiation (GO:0045586)2.59736673
130negative regulation of fatty acid transport (GO:2000192)2.59021000
131positive regulation of neurotransmitter secretion (GO:0001956)2.57544303
132regulation of synaptic transmission, glutamatergic (GO:0051966)2.57152062
133activation of JUN kinase activity (GO:0007257)2.56893566
134negative regulation of cell killing (GO:0031342)2.56032926
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56032926
136behavioral defense response (GO:0002209)2.55181779
137antigen processing and presentation of endogenous antigen (GO:0019883)2.52608674
138intracellular estrogen receptor signaling pathway (GO:0030520)2.50658145
139histone demethylation (GO:0016577)2.49357462
140positive regulation of CREB transcription factor activity (GO:0032793)2.47069168
141embryonic process involved in female pregnancy (GO:0060136)2.45282933
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.43547274
143cell-substrate junction assembly (GO:0007044)2.42446467
144regulation of defense response to virus by virus (GO:0050690)2.42189670
145leukocyte aggregation (GO:0070486)2.40876564
146positive regulation of Rap GTPase activity (GO:0032854)2.40540116
147regulation of gamma-delta T cell activation (GO:0046643)2.39436980
148ear development (GO:0043583)2.37727931
149glucocorticoid receptor signaling pathway (GO:0042921)2.34940562
150regulation of nucleobase-containing compound transport (GO:0032239)2.34357193
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34097734
152germinal center formation (GO:0002467)2.33542224
153modulation by symbiont of host cellular process (GO:0044068)2.32798072
154protein targeting to plasma membrane (GO:0072661)2.31157478
155stress fiber assembly (GO:0043149)2.30489814
156response to fluid shear stress (GO:0034405)2.30484492
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30274449
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26346102
159histone H3-K4 methylation (GO:0051568)2.25903482
160negative regulation of myotube differentiation (GO:0010832)2.25750056
161modulation by virus of host process (GO:0019054)2.24241246
162maternal placenta development (GO:0001893)2.21985236
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20420143
164skin morphogenesis (GO:0043589)2.19249730
165negative regulation of type 2 immune response (GO:0002829)2.18109777
166apoptotic process involved in morphogenesis (GO:0060561)2.16319435
167activation of Rac GTPase activity (GO:0032863)2.16148405
168positive regulation of protein deacetylation (GO:0090312)2.15754891
169activation of MAPKKK activity (GO:0000185)2.15099390
170barbed-end actin filament capping (GO:0051016)2.14792935
171eye morphogenesis (GO:0048592)2.14577334
172stress granule assembly (GO:0034063)2.14556192
173regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.14498535
174regulation of RNA export from nucleus (GO:0046831)2.13423391
175protein demethylation (GO:0006482)2.13278913
176protein dealkylation (GO:0008214)2.13278913
177embryonic eye morphogenesis (GO:0048048)2.13189168
178B cell receptor signaling pathway (GO:0050853)2.12196448
179regulation of fatty acid beta-oxidation (GO:0031998)2.11814698
180cortical actin cytoskeleton organization (GO:0030866)2.11712332
181hypotonic response (GO:0006971)2.11023614
182cellular response to monoamine stimulus (GO:0071868)2.10461553
183cellular response to catecholamine stimulus (GO:0071870)2.10461553
184regulation of lipid kinase activity (GO:0043550)2.08654921
1853-UTR-mediated mRNA stabilization (GO:0070935)2.08550474
186negative regulation of Ras protein signal transduction (GO:0046580)2.08266491
187cellular response to epidermal growth factor stimulus (GO:0071364)2.07997584
188embryonic camera-type eye morphogenesis (GO:0048596)2.07390563
189regulation of early endosome to late endosome transport (GO:2000641)2.07233900
190peptidyl-threonine phosphorylation (GO:0018107)2.05936402
191peptidyl-threonine modification (GO:0018210)2.05833282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62685188
2* MYC_22102868_ChIP-Seq_BL_Human3.15735041
3VDR_21846776_ChIP-Seq_THP-1_Human2.81849260
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76908598
5DROSHA_22980978_ChIP-Seq_HELA_Human2.73476995
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.70781706
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.66543764
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66536166
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63189542
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.63000561
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60095804
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55821458
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55821458
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.45046191
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39803811
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30921957
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26742953
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23004920
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21940910
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18496261
21REST_21632747_ChIP-Seq_MESCs_Mouse2.17754891
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.15466723
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14030253
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09139340
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.08320034
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06484726
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06331336
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04112749
29RACK7_27058665_Chip-Seq_MCF-7_Human2.03676941
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90956302
31GBX2_23144817_ChIP-Seq_PC3_Human1.87869195
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86378301
33KDM2B_26808549_Chip-Seq_K562_Human1.85039061
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84437752
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84263378
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.84240070
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83172746
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.83020324
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80432100
40VDR_24763502_ChIP-Seq_THP-1_Human1.80156075
41* MAF_26560356_Chip-Seq_TH1_Human1.76468210
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73549581
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72645781
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.68127740
45* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67919043
46* UTX_26944678_Chip-Seq_JUKART_Human1.63802348
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62532513
48* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61535644
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61520756
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61096126
51AR_21572438_ChIP-Seq_LNCaP_Human1.60753247
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60043574
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54252341
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52397518
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51835415
56MAF_26560356_Chip-Seq_TH2_Human1.51754874
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50916988
58* KDM2B_26808549_Chip-Seq_DND41_Human1.48963617
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48559652
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46681487
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45250853
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.43966090
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42478051
64* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42373386
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.41857671
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.40460974
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39271983
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37194687
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35548178
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33579398
71* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32923302
72* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31092147
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.28685619
74RUNX_20019798_ChIP-Seq_JUKART_Human1.27688604
75* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27457489
76LXR_22292898_ChIP-Seq_THP-1_Human1.25626653
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25537355
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.24939596
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24902339
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24631931
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.24190406
82* AR_19668381_ChIP-Seq_PC3_Human1.23819618
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23258910
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22846674
85* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22662517
86SPI1_23127762_ChIP-Seq_K562_Human1.19044300
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18792898
88CLOCK_20551151_ChIP-Seq_293T_Human1.17983322
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17744524
90* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17333231
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15613254
92P68_20966046_ChIP-Seq_HELA_Human1.15457431
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15117428
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.12956528
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11498583
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09988059
97* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09981012
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.09666335
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09409620
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08683395
101AHR_22903824_ChIP-Seq_MCF-7_Human1.08250035
102ZNF274_21170338_ChIP-Seq_K562_Hela1.06806363
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06535953
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06224834
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.05168097
106SMAD4_21799915_ChIP-Seq_A2780_Human1.04947914
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04803543
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04278354
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03898971
110SCL_19346495_ChIP-Seq_HPC-7_Human1.03817682
111* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02962684
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02161306
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01177486
114CTCF_27219007_Chip-Seq_Bcells_Human1.01175206
115GATA1_19941826_ChIP-Seq_K562_Human1.01034030
116TP53_22127205_ChIP-Seq_IMR90_Human1.00342946
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99673506
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.99004290
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98492880
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97546597
121* CREB1_26743006_Chip-Seq_LNCaP_Human0.97379897
122CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97140305
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96998578
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96956082
125* NCOR1_26117541_ChIP-Seq_K562_Human0.96704202
126IRF8_22096565_ChIP-ChIP_GC-B_Human0.95804487
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94779056
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94569068
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94186012
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94073162
131* TCF7_22412390_ChIP-Seq_EML_Mouse0.94021595
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93836045
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.93817358
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93746741
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.93738044
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.93585782
137* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93545919
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92901712
139* MYB_26560356_Chip-Seq_TH1_Human0.92524458
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.91658056
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.91644650
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.91334681
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.91334681
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89877724
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.89772568
146* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89410885
147SMC4_20622854_ChIP-Seq_HELA_Human0.89384782
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88821501
149RXR_22108803_ChIP-Seq_LS180_Human0.88299751
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87822257
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87473446
152TP53_16413492_ChIP-PET_HCT116_Human0.87377224
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87101306
154TP53_23651856_ChIP-Seq_MEFs_Mouse0.86887112
155STAT3_23295773_ChIP-Seq_U87_Human0.85182611
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.84699590
157TP53_20018659_ChIP-ChIP_R1E_Mouse0.84405371
158* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84126624
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83957465
160KLF4_19829295_ChIP-Seq_ESCs_Human0.83411206
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83357732
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82983618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.63593968
2MP0003635_abnormal_synaptic_transmissio4.13917882
3MP0004270_analgesia3.64235642
4MP0003880_abnormal_central_pattern3.63351156
5MP0002063_abnormal_learning/memory/cond3.29387477
6MP0008438_abnormal_cutaneous_collagen3.16378624
7MP0009745_abnormal_behavioral_response3.05491457
8MP0002822_catalepsy3.05070229
9MP0009780_abnormal_chondrocyte_physiolo2.99187036
10MP0003763_abnormal_thymus_physiology2.86473843
11MP0005423_abnormal_somatic_nervous2.83603646
12MP0002064_seizures2.74217625
13MP0005409_darkened_coat_color2.54091221
14MP0002572_abnormal_emotion/affect_behav2.40648796
15MP0001968_abnormal_touch/_nociception2.27547521
16MP0004858_abnormal_nervous_system2.25780243
17MP0002009_preneoplasia2.25477490
18MP0001958_emphysema2.21214252
19MP0002877_abnormal_melanocyte_morpholog2.20454727
20MP0009046_muscle_twitch2.19695289
21MP0002734_abnormal_mechanical_nocicepti2.15849618
22MP0002909_abnormal_adrenal_gland2.14922491
23MP0000569_abnormal_digit_pigmentation2.12704972
24MP0001486_abnormal_startle_reflex2.09255571
25MP0003436_decreased_susceptibility_to2.06440163
26MP0004811_abnormal_neuron_physiology2.01261151
27MP0008961_abnormal_basal_metabolism1.98801106
28MP0003329_amyloid_beta_deposits1.97947314
29MP0005503_abnormal_tendon_morphology1.96741136
30MP0000778_abnormal_nervous_system1.95922722
31MP0001849_ear_inflammation1.94961134
32MP0003279_aneurysm1.94916137
33MP0005275_abnormal_skin_tensile1.92475243
34MP0002396_abnormal_hematopoietic_system1.90104574
35MP0003566_abnormal_cell_adhesion1.88133038
36MP0008569_lethality_at_weaning1.85248730
37MP0002272_abnormal_nervous_system1.84565926
38MP0003787_abnormal_imprinting1.79602756
39MP0001501_abnormal_sleep_pattern1.79022832
40MP0004381_abnormal_hair_follicle1.78024248
41MP0004885_abnormal_endolymph1.77818499
42MP0003283_abnormal_digestive_organ1.74989862
43MP0004947_skin_inflammation1.73457939
44MP0002733_abnormal_thermal_nociception1.72931316
45MP0010234_abnormal_vibrissa_follicle1.71082526
46MP0000955_abnormal_spinal_cord1.64945188
47MP0001440_abnormal_grooming_behavior1.64649531
48MP0002184_abnormal_innervation1.64333158
49MP0009278_abnormal_bone_marrow1.63362936
50MP0002735_abnormal_chemical_nociception1.60140018
51MP0000733_abnormal_muscle_development1.60087042
52MP0002557_abnormal_social/conspecific_i1.59348040
53MP0001970_abnormal_pain_threshold1.56664133
54MP0008260_abnormal_autophagy1.49965327
55MP0002166_altered_tumor_susceptibility1.46956566
56MP0004808_abnormal_hematopoietic_stem1.43037267
57MP0001873_stomach_inflammation1.41822654
58MP0002736_abnormal_nociception_after1.40927701
59MP0003879_abnormal_hair_cell1.39968953
60MP0000703_abnormal_thymus_morphology1.36806972
61MP0002067_abnormal_sensory_capabilities1.36003854
62MP0004185_abnormal_adipocyte_glucose1.35671641
63MP0004924_abnormal_behavior1.34604524
64MP0005386_behavior/neurological_phenoty1.34604524
65MP0003633_abnormal_nervous_system1.33791525
66MP0003122_maternal_imprinting1.33732597
67MP0002882_abnormal_neuron_morphology1.30537452
68MP0005187_abnormal_penis_morphology1.29445421
69MP0005058_abnormal_lysosome_morphology1.25599916
70MP0002060_abnormal_skin_morphology1.25421170
71MP0003453_abnormal_keratinocyte_physiol1.25353743
72MP0002066_abnormal_motor_capabilities/c1.23775049
73MP0005623_abnormal_meninges_morphology1.23396241
74MP0002249_abnormal_larynx_morphology1.23194369
75MP0003705_abnormal_hypodermis_morpholog1.21130373
76MP0001177_atelectasis1.18196945
77MP0002152_abnormal_brain_morphology1.17842612
78MP0001800_abnormal_humoral_immune1.16753456
79MP0000767_abnormal_smooth_muscle1.14946605
80MP0000685_abnormal_immune_system1.10359674
81MP0005451_abnormal_body_composition1.07848564
82MP0001835_abnormal_antigen_presentation1.05745839
83MP0000858_altered_metastatic_potential1.05669894
84MP0002398_abnormal_bone_marrow1.05107041
85MP0002998_abnormal_bone_remodeling1.04685924
86MP0001851_eye_inflammation1.03684214
87MP0003866_abnormal_defecation1.02769381
88MP0003303_peritoneal_inflammation1.02740288
89MP0005000_abnormal_immune_tolerance1.02513296
90MP0003075_altered_response_to1.01066815
91MP0003631_nervous_system_phenotype1.00821865
92MP0008874_decreased_physiological_sensi1.00663982
93MP0005375_adipose_tissue_phenotype1.00049164
94MP0000604_amyloidosis1.00034257
95MP0002069_abnormal_eating/drinking_beha0.99071203
96MP0000537_abnormal_urethra_morphology0.97234745
97MP0000678_abnormal_parathyroid_gland0.96558072
98MP0002420_abnormal_adaptive_immunity0.96502973
99MP0002796_impaired_skin_barrier0.96130168
100MP0001348_abnormal_lacrimal_gland0.95937435
101MP0005646_abnormal_pituitary_gland0.95861161
102MP0005310_abnormal_salivary_gland0.95572456
103MP0010352_gastrointestinal_tract_polyps0.95332091
104MP0005666_abnormal_adipose_tissue0.95124330
105MP0000013_abnormal_adipose_tissue0.94068435
106MP0001819_abnormal_immune_cell0.93851290
107MP0005621_abnormal_cell_physiology0.93782045
108MP0010155_abnormal_intestine_physiology0.92823735
109MP0005023_abnormal_wound_healing0.92733179
110MP0003300_gastrointestinal_ulcer0.92192212
111MP0005387_immune_system_phenotype0.92158336
112MP0001790_abnormal_immune_system0.92158336
113MP0001299_abnormal_eye_distance/0.91922029
114MP0005257_abnormal_intraocular_pressure0.91333436
115MP0002933_joint_inflammation0.91050626
116MP0000534_abnormal_ureter_morphology0.90455434
117MP0003183_abnormal_peptide_metabolism0.89550096
118MP0002089_abnormal_postnatal_growth/wei0.87752752
119MP0005025_abnormal_response_to0.86493921
120MP0004510_myositis0.86416003
121MP0000751_myopathy0.86368506
122MP0002405_respiratory_system_inflammati0.86191744
123MP0001533_abnormal_skeleton_physiology0.85824126
124MP0000716_abnormal_immune_system0.85324728
125MP0002723_abnormal_immune_serum0.84522427
126MP0005167_abnormal_blood-brain_barrier0.82591238
127MP0002452_abnormal_antigen_presenting0.82450216
128MP0002932_abnormal_joint_morphology0.81411558
129MP0001243_abnormal_dermal_layer0.80084648
130MP0003191_abnormal_cellular_cholesterol0.79922112
131MP0002234_abnormal_pharynx_morphology0.79912772
132MP0003861_abnormal_nervous_system0.78585660
133MP0003045_fibrosis0.78044491
134MP0002419_abnormal_innate_immunity0.76638247
135MP0005076_abnormal_cell_differentiation0.76172682
136MP0004130_abnormal_muscle_cell0.75705202
137MP0001502_abnormal_circadian_rhythm0.75322009
138MP0003385_abnormal_body_wall0.75317404
139MP0002108_abnormal_muscle_morphology0.75149826
140MP0004233_abnormal_muscle_weight0.75115859
141MP0003828_pulmonary_edema0.74871100
142MP0005390_skeleton_phenotype0.74634376
143MP0009333_abnormal_splenocyte_physiolog0.73708694
144MP0009931_abnormal_skin_appearance0.73494506
145MP0005394_taste/olfaction_phenotype0.72881393
146MP0005499_abnormal_olfactory_system0.72881393
147MP0002722_abnormal_immune_system0.72306296
148MP0008872_abnormal_physiological_respon0.71807820
149MP0003172_abnormal_lysosome_physiology0.71418341
150MP0002006_tumorigenesis0.71196050
151MP0003634_abnormal_glial_cell0.70223402
152MP0009384_cardiac_valve_regurgitation0.69961878
153MP0003690_abnormal_glial_cell0.69564698
154MP0005535_abnormal_body_temperature0.68822781
155MP0005501_abnormal_skin_physiology0.68286763
156MP0001984_abnormal_olfaction0.68215329
157MP0004264_abnormal_extraembryonic_tissu0.67920535
158MP0005645_abnormal_hypothalamus_physiol0.67866505
159MP0000631_abnormal_neuroendocrine_gland0.67537020
160MP0000759_abnormal_skeletal_muscle0.67486060
161MP0002429_abnormal_blood_cell0.65539249
162MP0004085_abnormal_heartbeat0.64905818
163MP0006276_abnormal_autonomic_nervous0.64799186
164MP0002896_abnormal_bone_mineralization0.64044910
165MP0000003_abnormal_adipose_tissue0.62537148
166MP0003119_abnormal_digestive_system0.61837592
167MP0010769_abnormal_survival0.61422199
168MP0001943_abnormal_respiration0.61298863
169MP0005248_abnormal_Harderian_gland0.60059695
170MP0003632_abnormal_nervous_system0.59469874
171MP0003115_abnormal_respiratory_system0.58485719
172MP0002082_postnatal_lethality0.57010229
173MP0010770_preweaning_lethality0.57010229
174MP0002090_abnormal_vision0.56785838
175MP0010768_mortality/aging0.55797092
176MP0003091_abnormal_cell_migration0.55728008

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.45219184
2Focal motor seizures (HP:0011153)4.47564652
3Focal seizures (HP:0007359)4.15321781
4Visual hallucinations (HP:0002367)3.93849009
5Broad face (HP:0000283)3.59045352
6Protrusio acetabuli (HP:0003179)3.56877629
7Abnormality of the lower motor neuron (HP:0002366)3.31411242
8Supranuclear gaze palsy (HP:0000605)3.26673518
9Papilledema (HP:0001085)3.21436662
10Ankle clonus (HP:0011448)3.15109619
11Action tremor (HP:0002345)3.04027293
12Insomnia (HP:0100785)3.03846990
13Premature rupture of membranes (HP:0001788)3.01769668
14Hyperacusis (HP:0010780)3.00136363
15Impaired vibration sensation in the lower limbs (HP:0002166)2.94136678
16Abnormality of the fingertips (HP:0001211)2.87118653
17Pointed chin (HP:0000307)2.82387167
18Epileptic encephalopathy (HP:0200134)2.81575123
19Abnormal social behavior (HP:0012433)2.79899333
20Impaired social interactions (HP:0000735)2.79899333
21Depression (HP:0000716)2.73864035
22Poor eye contact (HP:0000817)2.73339976
23Urinary bladder sphincter dysfunction (HP:0002839)2.71160120
24Macroorchidism (HP:0000053)2.67595939
25Torticollis (HP:0000473)2.67262046
26Atrophic scars (HP:0001075)2.66140830
27Urinary urgency (HP:0000012)2.65190305
28Thin bony cortex (HP:0002753)2.63282291
29Progressive cerebellar ataxia (HP:0002073)2.62305233
30Annular pancreas (HP:0001734)2.59183821
31Elfin facies (HP:0004428)2.57876512
32Genetic anticipation (HP:0003743)2.55856136
33Absence seizures (HP:0002121)2.55502802
34Megalencephaly (HP:0001355)2.51612531
35Aortic dissection (HP:0002647)2.51417649
36Mutism (HP:0002300)2.50930260
37Aortic aneurysm (HP:0004942)2.48136179
38Atonic seizures (HP:0010819)2.47576930
39Ankyloglossia (HP:0010296)2.47057335
40Eczematoid dermatitis (HP:0000976)2.44771971
41Generalized tonic-clonic seizures (HP:0002069)2.44468129
42Broad-based gait (HP:0002136)2.42637856
43Postural instability (HP:0002172)2.41845310
44Cerebral inclusion bodies (HP:0100314)2.41679572
45Fragile skin (HP:0001030)2.40535479
46Hemiplegia (HP:0002301)2.40526741
47Arterial tortuosity (HP:0005116)2.38658701
48Genu recurvatum (HP:0002816)2.37014986
49Vascular tortuosity (HP:0004948)2.36639853
50Focal dystonia (HP:0004373)2.36281660
51Shallow orbits (HP:0000586)2.33844911
52Febrile seizures (HP:0002373)2.29720388
53Renovascular hypertension (HP:0100817)2.28764205
54Insidious onset (HP:0003587)2.28164764
55Termporal pattern (HP:0011008)2.28164764
56Mitral regurgitation (HP:0001653)2.26585006
57Amyotrophic lateral sclerosis (HP:0007354)2.25227891
58Drooling (HP:0002307)2.24221763
59Excessive salivation (HP:0003781)2.24221763
60Stereotypic behavior (HP:0000733)2.23729292
61Obstructive sleep apnea (HP:0002870)2.22698964
62Renal duplication (HP:0000075)2.21614716
63Overriding aorta (HP:0002623)2.20213018
64Dislocated radial head (HP:0003083)2.19065596
65Asymmetry of the thorax (HP:0001555)2.18951587
66Abnormality of oral frenula (HP:0000190)2.17806046
67Dialeptic seizures (HP:0011146)2.17561231
68Abnormal eating behavior (HP:0100738)2.16786681
69Cervical subluxation (HP:0003308)2.16106290
70Truncal ataxia (HP:0002078)2.15915064
71Spastic gait (HP:0002064)2.15616028
72Craniofacial dystonia (HP:0012179)2.12909378
73Aneurysm (HP:0002617)2.12040381
74Ulnar bowing (HP:0003031)2.11213814
75Dysmetria (HP:0001310)2.11192814
76Abnormality of the radial head (HP:0003995)2.09358890
77Dysmetric saccades (HP:0000641)2.09147357
78Dysdiadochokinesis (HP:0002075)2.08552476
79Impaired smooth pursuit (HP:0007772)2.08373842
80Neoplasm of the heart (HP:0100544)2.08238236
81Increased IgE level (HP:0003212)2.08099622
82Anxiety (HP:0000739)2.07938175
83Cerebral aneurysm (HP:0004944)2.07507653
84Amblyopia (HP:0000646)2.07221284
85Hepatoblastoma (HP:0002884)2.06196319
86Lower limb amyotrophy (HP:0007210)2.04085389
87Disproportionate tall stature (HP:0001519)2.03175647
88Biconcave vertebral bodies (HP:0004586)2.02480009
89Overgrowth (HP:0001548)2.02209476
90Cellulitis (HP:0100658)2.00717800
91Intention tremor (HP:0002080)1.99615431
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99377019
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.97924827
94Apathy (HP:0000741)1.96965998
95Neurofibrillary tangles (HP:0002185)1.96950586
96Wormian bones (HP:0002645)1.96799390
97Broad metatarsal (HP:0001783)1.96660657
98Long palpebral fissure (HP:0000637)1.95718414
99Spondylolisthesis (HP:0003302)1.95609539
100Bowel diverticulosis (HP:0005222)1.95467239
101Flat acetabular roof (HP:0003180)1.95354889
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93156621
103Short 4th metacarpal (HP:0010044)1.93156621
104Joint laxity (HP:0001388)1.92622257
105Sacral dimple (HP:0000960)1.92121160
106Turricephaly (HP:0000262)1.91761990
107Resting tremor (HP:0002322)1.91739584
108Ventricular fibrillation (HP:0001663)1.91044321
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90549004
110Aortic regurgitation (HP:0001659)1.90392204
111Long eyelashes (HP:0000527)1.90168944
112Germ cell neoplasia (HP:0100728)1.90031084
113Lower limb asymmetry (HP:0100559)1.89282566
114Vertebral arch anomaly (HP:0008438)1.88731127
115Narrow palate (HP:0000189)1.88418607
116Absent frontal sinuses (HP:0002688)1.87056118
117Blue sclerae (HP:0000592)1.86156272
118Bradykinesia (HP:0002067)1.85897806
119Peritonitis (HP:0002586)1.85747853
120Abnormality of the corticospinal tract (HP:0002492)1.85075947
121Spinal cord lesions (HP:0100561)1.85022656
122Syringomyelia (HP:0003396)1.85022656
123Impaired vibratory sensation (HP:0002495)1.84794909
124Interstitial pulmonary disease (HP:0006530)1.84710300
125Abnormality of ocular smooth pursuit (HP:0000617)1.84547827
126Agitation (HP:0000713)1.83802869
127Lower limb muscle weakness (HP:0007340)1.82972854
128Upper limb amyotrophy (HP:0009129)1.82855329
129Distal upper limb amyotrophy (HP:0007149)1.82855329
130Distal lower limb amyotrophy (HP:0008944)1.82782633
131Inappropriate behavior (HP:0000719)1.81566305
132Heterotopia (HP:0002282)1.81124672
133Sparse lateral eyebrow (HP:0005338)1.80949012
134Gaze-evoked nystagmus (HP:0000640)1.80848516
135Colitis (HP:0002583)1.80264729
136Buphthalmos (HP:0000557)1.79857356
137Persistence of primary teeth (HP:0006335)1.79319563
138Hemiparesis (HP:0001269)1.79007588
139Emphysema (HP:0002097)1.78899465
140Obsessive-compulsive behavior (HP:0000722)1.78804214
141Flat cornea (HP:0007720)1.78210137
142Hypoventilation (HP:0002791)1.78046923
143Mild short stature (HP:0003502)1.76440334
144Bladder diverticulum (HP:0000015)1.76017298
145Bronchomalacia (HP:0002780)1.75882971
146Subacute progressive viral hepatitis (HP:0006572)1.74738625
147Mitral valve prolapse (HP:0001634)1.74300431
148Status epilepticus (HP:0002133)1.73631937
149Dilatation of the ascending aorta (HP:0005111)1.73251132
150Lymphangioma (HP:0100764)1.72023800
151Abnormality of binocular vision (HP:0011514)1.71924889
152Spinal canal stenosis (HP:0003416)1.68838069
153Deep palmar crease (HP:0006191)1.68659346
154Hyperextensible skin (HP:0000974)1.68633895
155Osteolytic defects of the hand bones (HP:0009699)1.67340734
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.67340734
157Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66519991
158Patellar dislocation (HP:0002999)1.66450600
159Precocious puberty (HP:0000826)1.64850889
160Neonatal short-limb short stature (HP:0008921)1.64295288
161Wide anterior fontanel (HP:0000260)1.64071581
162Increased connective tissue (HP:0009025)1.62159738
163Gingivitis (HP:0000230)1.60592000
164Slow saccadic eye movements (HP:0000514)1.59305594
165Spontaneous hematomas (HP:0007420)1.55091833
166Vertebral compression fractures (HP:0002953)1.54884367
167Increased variability in muscle fiber diameter (HP:0003557)1.53950741
168Hypercortisolism (HP:0001578)1.52075634
169Onion bulb formation (HP:0003383)1.51403879
170Gastrointestinal inflammation (HP:0004386)1.50643245
171Abnormality of the thoracic spine (HP:0100711)1.50624008
172Viral hepatitis (HP:0006562)1.50288043
173Abnormal cortical bone morphology (HP:0003103)1.50061172
174Abnormality of the calcaneus (HP:0008364)1.46539165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.63097587
2MAP3K93.60291430
3EPHA43.59983530
4NTRK33.49491074
5CDK123.27405472
6PRKD32.54757602
7DAPK22.43475494
8SMG12.37403928
9PAK62.30158816
10MINK12.29669602
11SIK22.27043210
12MAP3K42.24862838
13NTRK22.15974498
14KSR22.13217815
15CAMKK12.09679799
16TRIB32.06138078
17MAP4K12.05680045
18TYRO31.99896315
19ERN11.99502085
20NTRK11.78827472
21TAOK11.69540015
22RIPK11.60727845
23STK381.59317260
24KSR11.55380044
25PDGFRA1.49574558
26PKN21.45833105
27CDK51.42920938
28MAP3K21.42688494
29PRKCH1.39293064
30LATS21.38363341
31MAP2K41.36272467
32TTN1.33108037
33ALK1.31560800
34MTOR1.22199563
35EPHB11.21791703
36BRD41.21195922
37RET1.21032575
38DDR21.20718938
39MAP2K71.17437702
40MARK21.15691101
41DAPK11.11203661
42FGFR21.10614133
43MAP3K101.09494974
44MAP3K71.08708564
45FES1.08565457
46CAMK1D1.08093523
47JAK11.06684853
48CAMK1G1.06344798
49ZAP701.05898702
50TYK21.05402665
51EEF2K1.04866981
52STK111.04528320
53HIPK21.02567990
54MAP3K131.01540311
55MAP2K30.95863231
56SIK30.94787402
57UHMK10.94634592
58MAP3K140.91356792
59PAK30.91113228
60ICK0.90990264
61JAK30.89283566
62PRKCG0.88054861
63SGK30.85515995
64MAP3K60.81959682
65RIPK40.81771988
66MAPK120.81458648
67DMPK0.81278586
68MAPK130.80784069
69LMTK20.80709619
70BTK0.79782339
71PRPF4B0.78651743
72PHKG10.77833553
73PHKG20.77833553
74CDC42BPA0.75671686
75PDK10.74200785
76CAMK10.73995943
77SCYL20.73499885
78RPS6KC10.71129873
79RPS6KL10.71129873
80MAPK70.70868639
81CDK150.70546849
82CSNK1G20.69341789
83BLK0.68692909
84PDGFRB0.68624827
85GRK50.67637502
86CDK180.67048069
87CSK0.65403616
88PTK60.64527905
89PNCK0.63374305
90HCK0.63309808
91ITK0.63271474
92PDPK10.62942982
93CDK140.62894856
94PTK2B0.62648374
95FYN0.62273123
96PLK20.62141811
97SGK10.61974349
98PRKCZ0.61625066
99BMX0.61361477
100RAF10.61013520
101CDK11A0.60329814
102SGK4940.59986058
103SGK2230.59986058
104IRAK30.58989262
105LRRK20.58640512
106MAP2K20.58101817
107PRKD20.57545436
108RPS6KA20.57297442
109MAPK110.57088286
110CDK40.56698954
111TBK10.55784513
112IRAK40.55147374
113TNK20.54411112
114PTK20.54210474
115DYRK1A0.54157853
116PAK20.53343594
117MST1R0.53336850
118CAMK40.53065631
119RPS6KA30.52590061
120MAP3K10.51560170
121SGK20.51544867
122RPS6KA60.51089357
123CDK60.50148914
124IKBKE0.50145482
125NEK60.50078708
126FGFR30.50037048
127MAP3K30.49719910
128TESK10.47586538
129CAMK2A0.47249198
130EPHA30.46652607
131FER0.46272763
132MAPK100.44911142
133MELK0.44877224
134ERBB20.44747209
135CSF1R0.44669920
136IRAK20.44537790
137TNIK0.44138519
138LCK0.44125752
139FGFR10.41678689
140SIK10.41669123
141WNK10.41070700
142GRK60.40846234
143FGFR40.40293868
144RPS6KB20.38651235
145MAPK80.38372781
146EPHB20.38174363
147CAMKK20.37733488
148PASK0.37593082
149SRC0.34736362

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.31085491
2Synaptic vesicle cycle_Homo sapiens_hsa047212.28039247
3Nicotine addiction_Homo sapiens_hsa050332.27007720
4Long-term potentiation_Homo sapiens_hsa047202.21876639
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20782179
6Circadian entrainment_Homo sapiens_hsa047132.17794550
7GABAergic synapse_Homo sapiens_hsa047272.06086114
8Glutamatergic synapse_Homo sapiens_hsa047242.03320978
9Nitrogen metabolism_Homo sapiens_hsa009101.94063019
10Amphetamine addiction_Homo sapiens_hsa050311.91773240
11Morphine addiction_Homo sapiens_hsa050321.89143697
12Acute myeloid leukemia_Homo sapiens_hsa052211.88429601
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85540903
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82582652
15Salivary secretion_Homo sapiens_hsa049701.80649021
16Gastric acid secretion_Homo sapiens_hsa049711.80423816
17Dopaminergic synapse_Homo sapiens_hsa047281.78548968
18B cell receptor signaling pathway_Homo sapiens_hsa046621.77011920
19Cholinergic synapse_Homo sapiens_hsa047251.72638591
20Insulin secretion_Homo sapiens_hsa049111.70664760
21Notch signaling pathway_Homo sapiens_hsa043301.66047373
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55547119
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53072125
24Glioma_Homo sapiens_hsa052141.49350506
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47536533
26Cocaine addiction_Homo sapiens_hsa050301.47334080
27GnRH signaling pathway_Homo sapiens_hsa049121.45552773
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44702283
29Renin secretion_Homo sapiens_hsa049241.44540960
30Type II diabetes mellitus_Homo sapiens_hsa049301.42494722
31Gap junction_Homo sapiens_hsa045401.33922378
32Estrogen signaling pathway_Homo sapiens_hsa049151.32197147
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32084943
34Osteoclast differentiation_Homo sapiens_hsa043801.30141309
35Other glycan degradation_Homo sapiens_hsa005111.27364485
36Axon guidance_Homo sapiens_hsa043601.26622531
37Long-term depression_Homo sapiens_hsa047301.22793110
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20593296
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19977606
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17692360
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17117973
42ErbB signaling pathway_Homo sapiens_hsa040121.16821060
43Prostate cancer_Homo sapiens_hsa052151.14706708
44Calcium signaling pathway_Homo sapiens_hsa040201.13946744
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13681553
46Thyroid cancer_Homo sapiens_hsa052161.13053416
47cAMP signaling pathway_Homo sapiens_hsa040241.13001179
48Melanogenesis_Homo sapiens_hsa049161.11207657
49Hepatitis B_Homo sapiens_hsa051611.09357608
50Dorso-ventral axis formation_Homo sapiens_hsa043201.05192630
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.03823055
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.03770693
53Endometrial cancer_Homo sapiens_hsa052131.03762495
54Taste transduction_Homo sapiens_hsa047421.02856189
55mTOR signaling pathway_Homo sapiens_hsa041501.00440616
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99143587
57Hepatitis C_Homo sapiens_hsa051600.98517445
58Toxoplasmosis_Homo sapiens_hsa051450.98215867
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.97550230
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96154126
61Amoebiasis_Homo sapiens_hsa051460.96141992
62Small cell lung cancer_Homo sapiens_hsa052220.95324219
63Measles_Homo sapiens_hsa051620.94860417
64MicroRNAs in cancer_Homo sapiens_hsa052060.94700435
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94495342
66VEGF signaling pathway_Homo sapiens_hsa043700.94420555
67Non-small cell lung cancer_Homo sapiens_hsa052230.93410320
68Bile secretion_Homo sapiens_hsa049760.92918567
69Serotonergic synapse_Homo sapiens_hsa047260.92811594
70TNF signaling pathway_Homo sapiens_hsa046680.92051675
71Choline metabolism in cancer_Homo sapiens_hsa052310.90680279
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90353737
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88687636
74Adherens junction_Homo sapiens_hsa045200.88238046
75Bladder cancer_Homo sapiens_hsa052190.87098853
76Influenza A_Homo sapiens_hsa051640.86972625
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85683665
78FoxO signaling pathway_Homo sapiens_hsa040680.85614087
79Thyroid hormone synthesis_Homo sapiens_hsa049180.85416535
80Leishmaniasis_Homo sapiens_hsa051400.83569388
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.83069747
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.80255442
83Rap1 signaling pathway_Homo sapiens_hsa040150.79677660
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76857938
85MAPK signaling pathway_Homo sapiens_hsa040100.76495865
86HTLV-I infection_Homo sapiens_hsa051660.75870443
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74618128
88Apoptosis_Homo sapiens_hsa042100.74182426
89Dilated cardiomyopathy_Homo sapiens_hsa054140.73506057
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73474020
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.71184019
92Primary immunodeficiency_Homo sapiens_hsa053400.70920108
93Colorectal cancer_Homo sapiens_hsa052100.70683325
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70173613
95ECM-receptor interaction_Homo sapiens_hsa045120.70112691
96Renal cell carcinoma_Homo sapiens_hsa052110.69521760
97Pathways in cancer_Homo sapiens_hsa052000.68105063
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67320017
99Endocytosis_Homo sapiens_hsa041440.67263621
100Glucagon signaling pathway_Homo sapiens_hsa049220.66942448
101Chronic myeloid leukemia_Homo sapiens_hsa052200.66506102
102HIF-1 signaling pathway_Homo sapiens_hsa040660.66496047
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66190961
104Tuberculosis_Homo sapiens_hsa051520.65928792
105Oocyte meiosis_Homo sapiens_hsa041140.65360461
106AMPK signaling pathway_Homo sapiens_hsa041520.65233381
107Pancreatic secretion_Homo sapiens_hsa049720.64561410
108Insulin signaling pathway_Homo sapiens_hsa049100.64264975
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63951286
110Lysine degradation_Homo sapiens_hsa003100.63895991
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.63200833
112Viral carcinogenesis_Homo sapiens_hsa052030.62328588
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.61705624
114Prolactin signaling pathway_Homo sapiens_hsa049170.61150682
115T cell receptor signaling pathway_Homo sapiens_hsa046600.60778280
116Ras signaling pathway_Homo sapiens_hsa040140.60172490
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59982876
118Wnt signaling pathway_Homo sapiens_hsa043100.59202696
119Proteoglycans in cancer_Homo sapiens_hsa052050.57568512
120Platelet activation_Homo sapiens_hsa046110.54816128
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54374239
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.54242648
123Chemokine signaling pathway_Homo sapiens_hsa040620.54134515
124Focal adhesion_Homo sapiens_hsa045100.53078868
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51163733
126Arginine biosynthesis_Homo sapiens_hsa002200.50443797
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49834076
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.49636654
129Inositol phosphate metabolism_Homo sapiens_hsa005620.49562854
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49030055
131Prion diseases_Homo sapiens_hsa050200.48444865
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47703121
133Insulin resistance_Homo sapiens_hsa049310.46988865
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46673225
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46480061
136Pancreatic cancer_Homo sapiens_hsa052120.43473275
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43392580
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42964512
139Hippo signaling pathway_Homo sapiens_hsa043900.42235093

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