CHD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic retina morphogenesis in camera-type eye (GO:0060059)4.06657755
2neuron cell-cell adhesion (GO:0007158)3.92254643
3positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.75789911
4pre-miRNA processing (GO:0031054)3.51221418
5axonal fasciculation (GO:0007413)3.39302250
6cerebellar Purkinje cell differentiation (GO:0021702)3.37315748
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33821131
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.32625634
9locomotory exploration behavior (GO:0035641)3.32413500
10histone H3-K36 demethylation (GO:0070544)3.31116636
11neuron recognition (GO:0008038)3.29101574
12histone H3-K4 trimethylation (GO:0080182)3.27219975
13vocalization behavior (GO:0071625)3.22554246
14embryonic camera-type eye morphogenesis (GO:0048596)3.22292575
15histone H3-K9 demethylation (GO:0033169)3.21208235
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16597886
17dendritic spine morphogenesis (GO:0060997)3.15123478
18layer formation in cerebral cortex (GO:0021819)3.13936721
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13670579
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11124518
21presynaptic membrane assembly (GO:0097105)3.09718020
22negative regulation of DNA repair (GO:0045738)3.09575175
23ionotropic glutamate receptor signaling pathway (GO:0035235)2.96255264
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.95976953
25regulation of NFAT protein import into nucleus (GO:0051532)2.90399133
26protein localization to synapse (GO:0035418)2.87832137
27histone H3-K4 methylation (GO:0051568)2.87536519
28glutamate receptor signaling pathway (GO:0007215)2.85563901
29regulation of RNA export from nucleus (GO:0046831)2.83095917
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82960311
31transmission of nerve impulse (GO:0019226)2.82808503
32regulation of glutamate receptor signaling pathway (GO:1900449)2.81886992
33monoubiquitinated protein deubiquitination (GO:0035520)2.81600852
34neuronal stem cell maintenance (GO:0097150)2.80984975
35histone H3-K9 methylation (GO:0051567)2.80929407
36dendrite morphogenesis (GO:0048813)2.80482561
37histone lysine methylation (GO:0034968)2.80395495
38lateral sprouting from an epithelium (GO:0060601)2.79163426
39presynaptic membrane organization (GO:0097090)2.78673037
40branching involved in prostate gland morphogenesis (GO:0060442)2.76688596
41histone lysine demethylation (GO:0070076)2.73882284
42ectodermal placode formation (GO:0060788)2.72352662
43interkinetic nuclear migration (GO:0022027)2.72124660
44ear development (GO:0043583)2.70313598
45head development (GO:0060322)2.67095104
46auditory behavior (GO:0031223)2.66825282
47mitotic sister chromatid cohesion (GO:0007064)2.66271442
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64176078
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.64176078
50regulation of translation, ncRNA-mediated (GO:0045974)2.64176078
51Golgi to endosome transport (GO:0006895)2.64059459
52photoreceptor cell differentiation (GO:0046530)2.63963729
53eye photoreceptor cell differentiation (GO:0001754)2.63963729
54apical protein localization (GO:0045176)2.63158794
55positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.62914785
56detection of calcium ion (GO:0005513)2.60926624
57peptidyl-lysine methylation (GO:0018022)2.60432948
58axon ensheathment in central nervous system (GO:0032291)2.60282125
59central nervous system myelination (GO:0022010)2.60282125
60central nervous system projection neuron axonogenesis (GO:0021952)2.60139495
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59925308
62establishment of nucleus localization (GO:0040023)2.59436859
63protein targeting to Golgi (GO:0000042)2.59393274
64synaptic transmission, glutamatergic (GO:0035249)2.59308120
65cytoplasmic mRNA processing body assembly (GO:0033962)2.59052341
66neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57961125
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57860892
68synaptic vesicle exocytosis (GO:0016079)2.56596566
69positive regulation by host of viral transcription (GO:0043923)2.56011784
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55942609
71regulation of histone H3-K27 methylation (GO:0061085)2.55796407
72regulation of protein polyubiquitination (GO:1902914)2.55160804
73glucocorticoid receptor signaling pathway (GO:0042921)2.54317909
74histone demethylation (GO:0016577)2.54186492
75negative regulation of histone methylation (GO:0031061)2.52052213
76peripheral nervous system axon ensheathment (GO:0032292)2.51491882
77myelination in peripheral nervous system (GO:0022011)2.51491882
78neuronal action potential propagation (GO:0019227)2.50690811
79neuronal ion channel clustering (GO:0045161)2.48423161
80asymmetric protein localization (GO:0008105)2.47957308
81neuron-neuron synaptic transmission (GO:0007270)2.46964513
82heart morphogenesis (GO:0003007)2.46105655
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45727452
84retina layer formation (GO:0010842)2.45236325
85innervation (GO:0060384)2.44565793
86embryonic eye morphogenesis (GO:0048048)2.43377748
87establishment of protein localization to Golgi (GO:0072600)2.42837502
88NLS-bearing protein import into nucleus (GO:0006607)2.42051995
89righting reflex (GO:0060013)2.42016911
90synaptic vesicle maturation (GO:0016188)2.41450277
91mechanosensory behavior (GO:0007638)2.41214731
92synaptic vesicle endocytosis (GO:0048488)2.39813096
93startle response (GO:0001964)2.39704720
94cell differentiation in hindbrain (GO:0021533)2.38491553
95positive regulation of synapse assembly (GO:0051965)2.37648890
96histone H3-K9 modification (GO:0061647)2.37172347
97exploration behavior (GO:0035640)2.36024938
98coronary vasculature morphogenesis (GO:0060977)2.35526196
99cerebellar granule cell differentiation (GO:0021707)2.35496679
100regulation of synaptic vesicle exocytosis (GO:2000300)2.33913396
101postsynaptic membrane organization (GO:0001941)2.33652952
102regulation of axon extension involved in axon guidance (GO:0048841)2.33482561
103gamma-aminobutyric acid signaling pathway (GO:0007214)2.33175175
104synapse assembly (GO:0007416)2.32856134
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32551397
106protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.31942238
107histone H4-K16 acetylation (GO:0043984)2.31581989
108response to auditory stimulus (GO:0010996)2.31516814
109positive regulation of glycogen biosynthetic process (GO:0045725)2.31399673
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30781386
111nucleus localization (GO:0051647)2.30563196
112positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.30052852
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.30052852
114regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28997594
115regulation of postsynaptic membrane potential (GO:0060078)2.28477394
116membrane hyperpolarization (GO:0060081)2.28472513
117mating behavior (GO:0007617)2.28278632
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.28063762
119peptidyl-lysine trimethylation (GO:0018023)2.27863410
120regulation of dendritic spine morphogenesis (GO:0061001)2.27738960
121synapse organization (GO:0050808)2.27654534
122nerve growth factor signaling pathway (GO:0038180)2.27381710
123regulation of fatty acid beta-oxidation (GO:0031998)2.26860317
124paraxial mesoderm development (GO:0048339)2.26533975
125nuclear pore complex assembly (GO:0051292)2.26433319
126genitalia morphogenesis (GO:0035112)2.25819134
127cell migration in hindbrain (GO:0021535)2.25597691
128regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.25328510
129gastrulation with mouth forming second (GO:0001702)2.24893713
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24725461
131regulation of axon guidance (GO:1902667)2.24678056
132artery development (GO:0060840)2.24063355
133protein K48-linked deubiquitination (GO:0071108)2.22641258
134long-term memory (GO:0007616)2.22390336
135cerebral cortex radially oriented cell migration (GO:0021799)2.21204676
136regulation of histone H3-K4 methylation (GO:0051569)2.21039782
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.20457157
138biotin metabolic process (GO:0006768)2.20313047
139membrane depolarization during action potential (GO:0086010)2.19752830
140stress granule assembly (GO:0034063)2.19475728
141forebrain development (GO:0030900)2.18666351
142positive regulation of catenin import into nucleus (GO:0035413)2.18636523
143embryonic foregut morphogenesis (GO:0048617)2.18633013
144regulation of ARF protein signal transduction (GO:0032012)2.18609199
145regulation of synapse assembly (GO:0051963)2.18490585
146histone methylation (GO:0016571)2.18463601
147regulation of establishment of cell polarity (GO:2000114)2.18010950
148regulation of nucleobase-containing compound transport (GO:0032239)2.17805605
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.17703219
150L-amino acid import (GO:0043092)2.17558349
151limb bud formation (GO:0060174)2.17281251
152cellular potassium ion homeostasis (GO:0030007)2.16615449
153protein demethylation (GO:0006482)2.16164134
154protein dealkylation (GO:0008214)2.16164134
155peptidyl-lysine dimethylation (GO:0018027)2.16053070
156long-term synaptic potentiation (GO:0060291)2.15511187
157regulation of gene silencing by RNA (GO:0060966)2.14902476
158regulation of posttranscriptional gene silencing (GO:0060147)2.14902476
159regulation of gene silencing by miRNA (GO:0060964)2.14902476
160nonmotile primary cilium assembly (GO:0035058)2.14288649
161membrane depolarization (GO:0051899)2.13873499
162regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.13195862
163corticosteroid receptor signaling pathway (GO:0031958)2.12822309
164response to monoamine (GO:0071867)2.11642901
165response to catecholamine (GO:0071869)2.11642901
166morphogenesis of an epithelial sheet (GO:0002011)2.11187411
167negative regulation of neurotransmitter transport (GO:0051589)2.11133365
168cochlea development (GO:0090102)2.10475682
169establishment of spindle orientation (GO:0051294)2.09459935
170lung epithelial cell differentiation (GO:0060487)2.09451219
171phospholipid translocation (GO:0045332)2.09439142
172lipid translocation (GO:0034204)2.09439142
173limb development (GO:0060173)2.09401373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55946321
2GBX2_23144817_ChIP-Seq_PC3_Human3.53524524
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84244247
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47315413
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40290548
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37224518
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31638626
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31148902
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.21594679
10AR_21572438_ChIP-Seq_LNCaP_Human2.18989725
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17269340
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17269340
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.15957532
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15364706
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.04083995
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02678678
17* DROSHA_22980978_ChIP-Seq_HELA_Human1.98120160
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97846171
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97396078
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95969822
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94800689
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92257319
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.89984351
24TAF15_26573619_Chip-Seq_HEK293_Human1.88474568
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.81831336
26FUS_26573619_Chip-Seq_HEK293_Human1.81644550
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81255867
28* PIAS1_25552417_ChIP-Seq_VCAP_Human1.79450252
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.79358620
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.76054925
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72145820
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72029709
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68301507
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68209746
35TP53_16413492_ChIP-PET_HCT116_Human1.66777595
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66099009
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65754973
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64321828
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.63770158
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63709038
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.60344764
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60299172
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60234813
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.60059303
45AHR_22903824_ChIP-Seq_MCF-7_Human1.59968308
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.59051133
47* P300_19829295_ChIP-Seq_ESCs_Human1.58373942
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.57801373
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55603119
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53687052
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53041519
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.52693090
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50551118
54* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50520352
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.49973625
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48115942
57* STAT3_23295773_ChIP-Seq_U87_Human1.46892164
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45883132
59ZNF274_21170338_ChIP-Seq_K562_Hela1.45874506
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.45325630
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44494697
62* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.43482097
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42223162
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41617448
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39937007
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39782180
67* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39135262
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38545209
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38052941
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37524039
71* TCF4_23295773_ChIP-Seq_U87_Human1.37359149
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36523191
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36299013
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.35903632
75* REST_21632747_ChIP-Seq_MESCs_Mouse1.35289903
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.34683270
77EWS_26573619_Chip-Seq_HEK293_Human1.34415127
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33884668
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33162072
80* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32314468
81* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32314468
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31907546
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31018247
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.30849686
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29280531
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28969546
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28797732
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.28285516
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27083750
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26558230
91AR_25329375_ChIP-Seq_VCAP_Human1.26360873
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25914966
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25738133
94* AR_19668381_ChIP-Seq_PC3_Human1.23897460
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23761054
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.22370422
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21532277
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20192793
99RNF2_27304074_Chip-Seq_NSC_Mouse1.20152656
100* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19801783
101* ER_23166858_ChIP-Seq_MCF-7_Human1.19149868
102RUNX2_22187159_ChIP-Seq_PCA_Human1.18878464
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18476617
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.16742151
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14617957
106IGF1R_20145208_ChIP-Seq_DFB_Human1.14063266
107* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13925169
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13305744
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12986184
110* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12811787
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12120331
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12081122
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11865049
114* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11827431
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11102710
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10746048
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10735120
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09594500
119* FOXA1_25552417_ChIP-Seq_VCAP_Human1.08720050
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08507053
121* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08022484
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.07836923
123BCAT_22108803_ChIP-Seq_LS180_Human1.07743580
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07488215
125* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06436663
126* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05772161
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.05766000
128TP53_18474530_ChIP-ChIP_U2OS_Human1.04683782
129* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02961174
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01656000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.13836305
2MP0004859_abnormal_synaptic_plasticity2.97996383
3MP0003890_abnormal_embryonic-extraembry2.75803940
4MP0008057_abnormal_DNA_replication2.43945559
5MP0003787_abnormal_imprinting2.41952962
6MP0000569_abnormal_digit_pigmentation2.40025250
7MP0003635_abnormal_synaptic_transmissio2.35054705
8MP0009046_muscle_twitch2.19598341
9MP0005409_darkened_coat_color2.16269254
10MP0000778_abnormal_nervous_system2.15844430
11MP0005076_abnormal_cell_differentiation2.13524958
12MP0001486_abnormal_startle_reflex2.11602350
13MP0004270_analgesia2.01292024
14MP0005423_abnormal_somatic_nervous1.95890249
15MP0009745_abnormal_behavioral_response1.92612305
16MP0000383_abnormal_hair_follicle1.87821872
17MP0002064_seizures1.83702161
18MP0003122_maternal_imprinting1.79098533
19MP0002063_abnormal_learning/memory/cond1.75449824
20MP0004885_abnormal_endolymph1.75229794
21MP0002272_abnormal_nervous_system1.72530731
22MP0002822_catalepsy1.68741176
23MP0008961_abnormal_basal_metabolism1.68446632
24* MP0002572_abnormal_emotion/affect_behav1.67210216
25MP0003121_genomic_imprinting1.66258494
26MP0002909_abnormal_adrenal_gland1.63243437
27MP0002734_abnormal_mechanical_nocicepti1.55862080
28MP0001299_abnormal_eye_distance/1.53790798
29MP0002184_abnormal_innervation1.50051158
30MP0002067_abnormal_sensory_capabilities1.47546448
31MP0001188_hyperpigmentation1.46362317
32MP0005171_absent_coat_pigmentation1.45427113
33MP0005551_abnormal_eye_electrophysiolog1.43917831
34MP0000566_synostosis1.42299929
35MP0003123_paternal_imprinting1.41875873
36MP0004145_abnormal_muscle_electrophysio1.41789482
37MP0004742_abnormal_vestibular_system1.41125639
38MP0003942_abnormal_urinary_system1.40960804
39MP0000631_abnormal_neuroendocrine_gland1.40712429
40MP0006072_abnormal_retinal_apoptosis1.38137709
41MP0008569_lethality_at_weaning1.36654758
42MP0002557_abnormal_social/conspecific_i1.36406692
43MP0004264_abnormal_extraembryonic_tissu1.36015886
44MP0002697_abnormal_eye_size1.34271496
45MP0009780_abnormal_chondrocyte_physiolo1.33243872
46MP0005646_abnormal_pituitary_gland1.32122138
47MP0000751_myopathy1.31871950
48MP0009703_decreased_birth_body1.30029214
49MP0003283_abnormal_digestive_organ1.29966926
50MP0001968_abnormal_touch/_nociception1.29927161
51MP0005645_abnormal_hypothalamus_physiol1.27936628
52MP0002882_abnormal_neuron_morphology1.27763213
53MP0001485_abnormal_pinna_reflex1.27697090
54MP0003115_abnormal_respiratory_system1.24785736
55MP0000955_abnormal_spinal_cord1.24679591
56MP0010678_abnormal_skin_adnexa1.24125214
57MP0002938_white_spotting1.23353157
58MP0001440_abnormal_grooming_behavior1.21595029
59MP0009672_abnormal_birth_weight1.21408357
60MP0002638_abnormal_pupillary_reflex1.20745639
61MP0002735_abnormal_chemical_nociception1.18055054
62MP0001501_abnormal_sleep_pattern1.14065293
63MP0002152_abnormal_brain_morphology1.13595988
64MP0001286_abnormal_eye_development1.12594296
65MP0005386_behavior/neurological_phenoty1.11369790
66MP0004924_abnormal_behavior1.11369790
67MP0003136_yellow_coat_color1.10942844
68MP0001984_abnormal_olfaction1.10276799
69MP0005623_abnormal_meninges_morphology1.09920583
70MP0002166_altered_tumor_susceptibility1.07622200
71MP0003861_abnormal_nervous_system1.07024699
72MP0002084_abnormal_developmental_patter1.06688109
73MP0003385_abnormal_body_wall1.06676084
74MP0006276_abnormal_autonomic_nervous1.06630890
75MP0003935_abnormal_craniofacial_develop1.05794399
76MP0003937_abnormal_limbs/digits/tail_de1.04516202
77MP0003315_abnormal_perineum_morphology1.04286965
78MP0003045_fibrosis1.04023067
79MP0004134_abnormal_chest_morphology1.01786567
80MP0003755_abnormal_palate_morphology1.01451355
81MP0003943_abnormal_hepatobiliary_system1.01438050
82MP0001346_abnormal_lacrimal_gland1.01121013
83MP0002752_abnormal_somatic_nervous1.00707040
84MP0001502_abnormal_circadian_rhythm1.00576710
85MP0002108_abnormal_muscle_morphology1.00438043
86MP0002837_dystrophic_cardiac_calcinosis1.00215023
87MP0002928_abnormal_bile_duct1.00125983
88MP0001970_abnormal_pain_threshold0.99237423
89MP0002751_abnormal_autonomic_nervous0.98503441
90MP0000920_abnormal_myelination0.98322194
91MP0004133_heterotaxia0.97485394
92MP0000432_abnormal_head_morphology0.97178542
93MP0002088_abnormal_embryonic_growth/wei0.96494463
94MP0004811_abnormal_neuron_physiology0.96221309
95MP0005220_abnormal_exocrine_pancreas0.95958106
96MP0008995_early_reproductive_senescence0.95501858
97MP0000049_abnormal_middle_ear0.94919433
98MP0003984_embryonic_growth_retardation0.94892311
99MP0008877_abnormal_DNA_methylation0.94330864
100MP0005394_taste/olfaction_phenotype0.94256637
101MP0005499_abnormal_olfactory_system0.94256637
102MP0001963_abnormal_hearing_physiology0.93985857
103MP0003938_abnormal_ear_development0.93355406
104MP0005253_abnormal_eye_physiology0.93151468
105MP0005503_abnormal_tendon_morphology0.92857136
106MP0000534_abnormal_ureter_morphology0.92269910
107MP0005187_abnormal_penis_morphology0.91432532
108MP0004233_abnormal_muscle_weight0.91212397
109MP0001177_atelectasis0.90051239
110MP0002009_preneoplasia0.89159284
111MP0000537_abnormal_urethra_morphology0.88824965
112* MP0002066_abnormal_motor_capabilities/c0.88323427
113MP0002733_abnormal_thermal_nociception0.87189661
114MP0000026_abnormal_inner_ear0.87053970
115MP0002249_abnormal_larynx_morphology0.86444157
116MP0003632_abnormal_nervous_system0.86245645
117MP0004272_abnormal_basement_membrane0.86224409
118MP0009250_abnormal_appendicular_skeleto0.85955056
119MP0002177_abnormal_outer_ear0.85765190
120MP0004215_abnormal_myocardial_fiber0.85749808
121MP0001529_abnormal_vocalization0.85063612
122MP0002116_abnormal_craniofacial_bone0.84872523
123MP0003634_abnormal_glial_cell0.84744540
124MP0002085_abnormal_embryonic_tissue0.84633738
125MP0002233_abnormal_nose_morphology0.84137492
126MP0002081_perinatal_lethality0.83842029
127MP0004085_abnormal_heartbeat0.83690766
128MP0009384_cardiac_valve_regurgitation0.83208132
129MP0000462_abnormal_digestive_system0.82432536
130MP0003941_abnormal_skin_development0.82405976
131MP0002092_abnormal_eye_morphology0.81929669
132MP0003137_abnormal_impulse_conducting0.81912090
133MP0002736_abnormal_nociception_after0.81893279
134MP0005380_embryogenesis_phenotype0.81858512
135MP0001672_abnormal_embryogenesis/_devel0.81858512
136MP0004185_abnormal_adipocyte_glucose0.81660812
137MP0000428_abnormal_craniofacial_morphol0.81291706
138MP0000733_abnormal_muscle_development0.79266303
139MP0003936_abnormal_reproductive_system0.78983945
140MP0010030_abnormal_orbit_morphology0.78522159
141MP0002114_abnormal_axial_skeleton0.77773357
142MP0001944_abnormal_pancreas_morphology0.77038091
143MP0004197_abnormal_fetal_growth/weight/0.76113739
144MP0002089_abnormal_postnatal_growth/wei0.75928932
145MP0000538_abnormal_urinary_bladder0.75284962
146MP0002160_abnormal_reproductive_system0.74108632
147MP0010770_preweaning_lethality0.73074724
148MP0002082_postnatal_lethality0.73074724

Predicted human phenotypes

RankGene SetZ-score
1Midline defect of the nose (HP:0004122)2.88919570
2Focal seizures (HP:0007359)2.85894910
3Hepatoblastoma (HP:0002884)2.84853861
4Focal motor seizures (HP:0011153)2.81176591
5Febrile seizures (HP:0002373)2.80985768
6Abnormality of the ischium (HP:0003174)2.76292156
7Heterotopia (HP:0002282)2.70112240
8Abnormality of the distal phalanx of the thumb (HP:0009617)2.56608480
9Atonic seizures (HP:0010819)2.51197521
10Broad face (HP:0000283)2.50798809
11Progressive cerebellar ataxia (HP:0002073)2.49630389
12Bronchomalacia (HP:0002780)2.49379725
13Hypoplastic ischia (HP:0003175)2.48795270
14Alacrima (HP:0000522)2.44460808
15Short 4th metacarpal (HP:0010044)2.39504760
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39504760
17Epileptic encephalopathy (HP:0200134)2.39499301
18Aqueductal stenosis (HP:0002410)2.37374942
19Abnormality of the pubic bones (HP:0003172)2.35873124
20Truncal obesity (HP:0001956)2.34276566
21Broad-based gait (HP:0002136)2.29886022
22Anal stenosis (HP:0002025)2.28721602
23Abnormality of the nasal septum (HP:0000419)2.21885404
24Neonatal hypoglycemia (HP:0001998)2.20568823
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.19863577
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19863577
27Long eyelashes (HP:0000527)2.15636057
28Volvulus (HP:0002580)2.15285364
29Macroorchidism (HP:0000053)2.14777638
30Drooling (HP:0002307)2.14347466
31Excessive salivation (HP:0003781)2.14347466
32Germ cell neoplasia (HP:0100728)2.14192786
33Decreased lacrimation (HP:0000633)2.13352528
34Narrow palate (HP:0000189)2.11486095
35Dysmetric saccades (HP:0000641)2.09289877
36Morphological abnormality of the middle ear (HP:0008609)2.09242500
37Hyperventilation (HP:0002883)2.08987338
38Gaze-evoked nystagmus (HP:0000640)2.08860984
39Flat acetabular roof (HP:0003180)2.08083333
40Cutaneous finger syndactyly (HP:0010554)2.07810405
41Anteriorly placed anus (HP:0001545)2.06754881
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.03314522
43Absent speech (HP:0001344)2.03248347
44Abnormality of the fingertips (HP:0001211)2.02083413
45Lip pit (HP:0100267)2.01498008
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00874007
47Genetic anticipation (HP:0003743)2.00700491
48Tracheomalacia (HP:0002779)1.99335714
49Broad palm (HP:0001169)1.97507955
50Widely spaced teeth (HP:0000687)1.94142149
51Sparse lateral eyebrow (HP:0005338)1.94018266
52Abnormal hair whorl (HP:0010721)1.93837441
53Laryngomalacia (HP:0001601)1.93530964
54Anophthalmia (HP:0000528)1.92910048
55Asymmetry of the thorax (HP:0001555)1.92856548
56Trigonocephaly (HP:0000243)1.89857382
57Genital tract atresia (HP:0001827)1.88764042
58Supernumerary ribs (HP:0005815)1.88718435
59Abnormality of the corticospinal tract (HP:0002492)1.88678872
60Obsessive-compulsive behavior (HP:0000722)1.88635705
61Myelomeningocele (HP:0002475)1.88110765
62Truncal ataxia (HP:0002078)1.86125151
63Thick eyebrow (HP:0000574)1.84434233
64Vaginal atresia (HP:0000148)1.82303693
65Urinary bladder sphincter dysfunction (HP:0002839)1.81513557
66Abnormality of incisor morphology (HP:0011063)1.80721789
67Abnormality of the aortic arch (HP:0012303)1.79638752
68Action tremor (HP:0002345)1.77871464
69Abnormality of the nasolacrimal system (HP:0000614)1.77851747
70Septate vagina (HP:0001153)1.77178333
71Cutaneous syndactyly (HP:0012725)1.76522951
72Abnormality of the 4th metacarpal (HP:0010012)1.76369335
73Oligodactyly (hands) (HP:0001180)1.76246855
74Abnormality of the labia minora (HP:0012880)1.75813581
75Synophrys (HP:0000664)1.75755302
76Overgrowth (HP:0001548)1.75602076
77Diastasis recti (HP:0001540)1.75116573
78Bell-shaped thorax (HP:0001591)1.74829175
79Cupped ear (HP:0000378)1.73442009
80Overlapping toe (HP:0001845)1.73290830
81Absence seizures (HP:0002121)1.72139438
82Hypoplastic labia majora (HP:0000059)1.71874296
83Deep philtrum (HP:0002002)1.70705254
84Narrow nasal bridge (HP:0000446)1.70504716
85Abnormality of the epiphyses of the hand (HP:0005924)1.70172992
86Abnormality of the lacrimal duct (HP:0011481)1.70057095
87Intellectual disability, moderate (HP:0002342)1.69860166
88Aplasia involving bones of the extremities (HP:0009825)1.69579266
89Aplasia involving bones of the upper limbs (HP:0009823)1.69579266
90Aplasia of the phalanges of the hand (HP:0009802)1.69579266
91Bifid scrotum (HP:0000048)1.69401653
92Broad thumb (HP:0011304)1.69233578
93Neoplasm of the oral cavity (HP:0100649)1.68794316
94Shallow orbits (HP:0000586)1.68742336
95Exotropia (HP:0000577)1.68552034
96Hyperacusis (HP:0010780)1.68448507
97Missing ribs (HP:0000921)1.67808850
98Overriding aorta (HP:0002623)1.67741807
99Abnormality of the diencephalon (HP:0010662)1.66988373
100Abnormality of the radial head (HP:0003995)1.66488094
101Limited elbow extension (HP:0001377)1.66422223
102Blue irides (HP:0000635)1.66399119
103Gonadotropin excess (HP:0000837)1.66009064
104Abnormality of the parietal bone (HP:0002696)1.65352761
105Hypoplasia of the maxilla (HP:0000327)1.65314245
106Shawl scrotum (HP:0000049)1.65313272
107Supernumerary bones of the axial skeleton (HP:0009144)1.64347638
108Thyroid carcinoma (HP:0002890)1.63694333
109Scanning speech (HP:0002168)1.63529179
110Depressed nasal tip (HP:0000437)1.63200245
111Smooth philtrum (HP:0000319)1.63121352
112Broad metatarsal (HP:0001783)1.63103584
113Renovascular hypertension (HP:0100817)1.62742722
114Hypoplastic iliac wings (HP:0002866)1.62688105
115Dislocated radial head (HP:0003083)1.62600496
116Abnormality of salivation (HP:0100755)1.62584522
117Abnormality of secondary sexual hair (HP:0009888)1.61701264
118Abnormality of the axillary hair (HP:0100134)1.61701264
119Flat cornea (HP:0007720)1.61089936
120Menstrual irregularities (HP:0000858)1.60159691
121Increased nuchal translucency (HP:0010880)1.59878010
122Hypopigmentation of the fundus (HP:0007894)1.59032457
123Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58616868
124Abnormality of the labia majora (HP:0012881)1.58420356
125Absent eyebrow (HP:0002223)1.58031854
126High anterior hairline (HP:0009890)1.57329193
127Hypoplastic nipples (HP:0002557)1.57142172
128Insidious onset (HP:0003587)1.57036739
129Termporal pattern (HP:0011008)1.57036739
130Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.56613015
131Hypoplastic ilia (HP:0000946)1.56101474
132Low anterior hairline (HP:0000294)1.56065918
133Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56046492
134Abnormality of the phalanges of the hallux (HP:0010057)1.56002765
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55992824
136Thickened helices (HP:0000391)1.55892020
13711 pairs of ribs (HP:0000878)1.55452655
138Short metatarsal (HP:0010743)1.54682064
139Gastroesophageal reflux (HP:0002020)1.54610849
140Chronic hepatic failure (HP:0100626)1.54397707
141Wide nose (HP:0000445)1.54176006
142Papillary thyroid carcinoma (HP:0002895)1.54014608
143Abnormality of the parathyroid morphology (HP:0011766)1.54010288
144Renal hypoplasia (HP:0000089)1.53513232
145Broad finger (HP:0001500)1.53064577
146Dialeptic seizures (HP:0011146)1.52406002
147Elfin facies (HP:0004428)1.51605924
148Gait imbalance (HP:0002141)1.51321846
149Vesicoureteral reflux (HP:0000076)1.51281402
150Tubulointerstitial nephritis (HP:0001970)1.50782971
151Neoplasm of the heart (HP:0100544)1.50279591
152Mixed hearing impairment (HP:0000410)1.50250468
153Sacral dimple (HP:0000960)1.50009298
154Urinary urgency (HP:0000012)1.49599078
155Renal duplication (HP:0000075)1.48773713
156Absent frontal sinuses (HP:0002688)1.48353289
157Ankle clonus (HP:0011448)1.48307306
158Aplasia cutis congenita (HP:0001057)1.48127988
159Protruding tongue (HP:0010808)1.48070817
160Vertebral arch anomaly (HP:0008438)1.47259643
161Bifid tongue (HP:0010297)1.46882403
162Skull defect (HP:0001362)1.46627097
163Hemiparesis (HP:0001269)1.45285662
164Tapered finger (HP:0001182)1.44923333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K42.99998599
2TRIB32.99818768
3NTRK32.92631950
4CASK2.51287899
5FGFR22.50194998
6PNCK2.49926876
7CAMK1G2.42329454
8EEF2K2.41781235
9TNIK2.29009246
10NTRK22.17810889
11MAP3K102.04521395
12EPHA42.02268119
13STK391.93146784
14MARK11.89562032
15WNK11.88295435
16MAPK131.77875241
17CAMK1D1.73322323
18PKN21.70225068
19FGFR31.66769338
20DMPK1.63687338
21FGFR41.63658701
22SIK21.62984414
23CDK121.58848600
24BRD41.56953615
25MAP2K71.47641358
26FRK1.33190359
27PKN11.32681132
28SGK21.23146905
29TYRO31.21905424
30SGK2231.19976022
31SGK4941.19976022
32NLK1.17445148
33BCR1.15967236
34UHMK11.15312185
35CDK31.13759003
36TNK21.11496482
37CSNK1A1L1.11020017
38ICK1.09740197
39CDC42BPA1.08446963
40OXSR11.05454203
41MINK11.03271384
42PAK61.03047783
43SIK11.01801624
44NEK61.01416884
45MARK21.01408116
46PDGFRA0.99018361
47AKT30.98010631
48SGK30.97348728
49RIPK10.96420655
50NTRK10.95155114
51INSRR0.93686343
52PLK20.92701696
53ERBB20.91919792
54MAP3K90.91364344
55MAPK150.91101986
56CDK50.87649698
57SGK10.87447619
58PDGFRB0.87271975
59PHKG20.86809628
60PHKG10.86809628
61PAK30.86419273
62STK38L0.86300951
63CSNK1G20.85795028
64CHUK0.84082951
65LATS10.83280903
66CAMKK10.81367270
67WNK40.81356182
68PASK0.80540471
69MAP2K40.80204314
70DYRK1A0.79137697
71PRKCE0.79137141
72RPS6KB20.78661907
73CDK70.77890258
74ROCK20.76710120
75DDR20.76253493
76MAP3K70.75939995
77CSNK1G10.74821823
78LMTK20.74818113
79KSR10.74407860
80ERBB30.72649947
81RET0.72488063
82PRKCH0.71376835
83CAMK2A0.70785670
84PRKD30.70655472
85PRKAA10.70448565
86FGR0.70335648
87MAPK100.69714112
88PIK3CA0.68286952
89DAPK20.67852332
90STK110.67825082
91MKNK20.66942102
92RPS6KB10.65984528
93MKNK10.61806259
94MAPKAPK50.61806017
95EPHA30.61491880
96FER0.61298341
97CSNK1E0.60397078
98CSNK1G30.60017281
99GSK3B0.59794328
100MAP3K60.59546699
101TAF10.59356785
102CAMK40.59206876
103PRKD10.59000852
104MAP3K20.58720899
105ROCK10.58604005
106MELK0.58562803
107PRPF4B0.57993330
108CSNK1D0.57903891
109MAPK80.57418342
110CAMK2B0.56099476
111CAMK10.55926647
112ATM0.55550109
113FGFR10.55388331
114WNK30.55234395
115NUAK10.55095050
116PRKG10.54901246
117MAPK140.54655193
118HIPK20.54347752
119BMPR1B0.53906674
120RPS6KA30.53302555
121PRKDC0.52528359
122FYN0.52120779
123TAOK10.52036971
124MTOR0.51927180
125ADRBK10.51119638
126RPS6KA20.50420902
127CAMK2D0.50151521
128EPHB20.50119212
129PRKCZ0.49912049
130CDK20.49095249
131CDK10.48724948
132AKT10.45716519
133STK380.45209572
134PRKAA20.43759170
135LATS20.42232642
136YES10.41075949
137CHEK10.39078084
138ATR0.38706003
139MAPK10.38034495
140PAK20.36874335
141DYRK1B0.35746627
142MAP2K20.34735141

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.84559378
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20611251
3Glutamatergic synapse_Homo sapiens_hsa047242.14744413
4Circadian entrainment_Homo sapiens_hsa047132.10741721
5GABAergic synapse_Homo sapiens_hsa047272.08756697
6Morphine addiction_Homo sapiens_hsa050322.08659646
7Taste transduction_Homo sapiens_hsa047421.80348845
8Long-term potentiation_Homo sapiens_hsa047201.75917832
9Fatty acid biosynthesis_Homo sapiens_hsa000611.72858880
10Serotonergic synapse_Homo sapiens_hsa047261.71948401
11Olfactory transduction_Homo sapiens_hsa047401.70586114
12Axon guidance_Homo sapiens_hsa043601.67249294
13Dopaminergic synapse_Homo sapiens_hsa047281.66614425
14Phototransduction_Homo sapiens_hsa047441.65047379
15Cholinergic synapse_Homo sapiens_hsa047251.64779327
16Renin secretion_Homo sapiens_hsa049241.59068965
17Amphetamine addiction_Homo sapiens_hsa050311.58790209
18Insulin secretion_Homo sapiens_hsa049111.55640497
19Salivary secretion_Homo sapiens_hsa049701.55624313
20Long-term depression_Homo sapiens_hsa047301.53261983
21Gastric acid secretion_Homo sapiens_hsa049711.46733177
22Synaptic vesicle cycle_Homo sapiens_hsa047211.42939128
23Calcium signaling pathway_Homo sapiens_hsa040201.40368819
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38663302
25Dilated cardiomyopathy_Homo sapiens_hsa054141.37137755
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34179396
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33638510
28Dorso-ventral axis formation_Homo sapiens_hsa043201.33502480
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30370004
30Oxytocin signaling pathway_Homo sapiens_hsa049211.30299208
31Cocaine addiction_Homo sapiens_hsa050301.30274073
32GnRH signaling pathway_Homo sapiens_hsa049121.26581435
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24289259
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22782476
35Type II diabetes mellitus_Homo sapiens_hsa049301.22325392
36cAMP signaling pathway_Homo sapiens_hsa040241.22156340
37Melanogenesis_Homo sapiens_hsa049161.21440254
38Basal cell carcinoma_Homo sapiens_hsa052171.21026428
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19342035
40Thyroid cancer_Homo sapiens_hsa052161.18672567
41ErbB signaling pathway_Homo sapiens_hsa040121.15791095
42Wnt signaling pathway_Homo sapiens_hsa043101.15234174
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13451095
44AMPK signaling pathway_Homo sapiens_hsa041521.12677264
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12405736
46Hedgehog signaling pathway_Homo sapiens_hsa043401.10934709
47Prolactin signaling pathway_Homo sapiens_hsa049171.09858033
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09555121
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.09245183
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08067758
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08029413
52Estrogen signaling pathway_Homo sapiens_hsa049151.06369637
53Chronic myeloid leukemia_Homo sapiens_hsa052201.05852149
54Gap junction_Homo sapiens_hsa045401.04818426
55Glucagon signaling pathway_Homo sapiens_hsa049221.04675394
56FoxO signaling pathway_Homo sapiens_hsa040681.02252995
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97961828
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.97848718
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97838014
60Choline metabolism in cancer_Homo sapiens_hsa052310.96624213
61Insulin signaling pathway_Homo sapiens_hsa049100.96260441
62Glioma_Homo sapiens_hsa052140.95672762
63Renal cell carcinoma_Homo sapiens_hsa052110.94213204
64MAPK signaling pathway_Homo sapiens_hsa040100.90750888
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.89423447
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88788165
67Small cell lung cancer_Homo sapiens_hsa052220.87914438
68Ras signaling pathway_Homo sapiens_hsa040140.87144166
69Endometrial cancer_Homo sapiens_hsa052130.86656026
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86531579
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85538601
72ABC transporters_Homo sapiens_hsa020100.84650462
73Insulin resistance_Homo sapiens_hsa049310.84254814
74Colorectal cancer_Homo sapiens_hsa052100.83032246
75Cardiac muscle contraction_Homo sapiens_hsa042600.81861935
76Pancreatic secretion_Homo sapiens_hsa049720.81666221
77Alcoholism_Homo sapiens_hsa050340.81580178
78ECM-receptor interaction_Homo sapiens_hsa045120.79823608
79Rap1 signaling pathway_Homo sapiens_hsa040150.76940351
80Lysine degradation_Homo sapiens_hsa003100.75722083
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75585308
82Focal adhesion_Homo sapiens_hsa045100.74958352
83Inositol phosphate metabolism_Homo sapiens_hsa005620.74672010
84Tight junction_Homo sapiens_hsa045300.73873924
85VEGF signaling pathway_Homo sapiens_hsa043700.72176040
86Hippo signaling pathway_Homo sapiens_hsa043900.72097875
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69977191
88Prostate cancer_Homo sapiens_hsa052150.69243533
89Pathways in cancer_Homo sapiens_hsa052000.67485177
90Melanoma_Homo sapiens_hsa052180.66771376
91Adherens junction_Homo sapiens_hsa045200.65527068
92MicroRNAs in cancer_Homo sapiens_hsa052060.65501954
93Acute myeloid leukemia_Homo sapiens_hsa052210.64612007
94Thyroid hormone synthesis_Homo sapiens_hsa049180.63878595
95Circadian rhythm_Homo sapiens_hsa047100.62975382
96mTOR signaling pathway_Homo sapiens_hsa041500.60916834
97Collecting duct acid secretion_Homo sapiens_hsa049660.59810906
98Notch signaling pathway_Homo sapiens_hsa043300.59666781
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59566836
100Proteoglycans in cancer_Homo sapiens_hsa052050.58784088
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58256769
102HIF-1 signaling pathway_Homo sapiens_hsa040660.57745677
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56879009
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56874236
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56045588
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.55225070
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55057332
108Oocyte meiosis_Homo sapiens_hsa041140.54991121
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54800985
110Ovarian steroidogenesis_Homo sapiens_hsa049130.54395952
111Ether lipid metabolism_Homo sapiens_hsa005650.52823288
112TGF-beta signaling pathway_Homo sapiens_hsa043500.52525776
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52504664
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52011179
115Non-small cell lung cancer_Homo sapiens_hsa052230.50399277
116Pancreatic cancer_Homo sapiens_hsa052120.49225698
117mRNA surveillance pathway_Homo sapiens_hsa030150.48851445
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48452982

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