CHD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.55696227
2regulation of NFAT protein import into nucleus (GO:0051532)4.06368082
3pre-miRNA processing (GO:0031054)3.99981847
4DNA unwinding involved in DNA replication (GO:0006268)3.88157433
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.77553375
6regulation of translation, ncRNA-mediated (GO:0045974)3.77553375
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.77553375
8negative regulation of osteoblast proliferation (GO:0033689)3.74306463
9mitotic chromosome condensation (GO:0007076)3.74227016
10cytoplasmic mRNA processing body assembly (GO:0033962)3.65864609
11regulation of histone H3-K27 methylation (GO:0061085)3.60011938
12mitotic sister chromatid cohesion (GO:0007064)3.56476727
13histone H3-K4 methylation (GO:0051568)3.53627004
14spliceosomal tri-snRNP complex assembly (GO:0000244)3.40613349
15nuclear pore complex assembly (GO:0051292)3.35682015
16mRNA splice site selection (GO:0006376)3.32583085
17peptidyl-lysine trimethylation (GO:0018023)3.30077742
18heterochromatin organization (GO:0070828)3.25075216
19paraxial mesoderm development (GO:0048339)3.24310148
20histone H3-K36 demethylation (GO:0070544)3.22819026
21snRNA metabolic process (GO:0016073)3.18115581
22alternative mRNA splicing, via spliceosome (GO:0000380)3.15662219
23negative regulation of cell killing (GO:0031342)3.14537327
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.14537327
25dosage compensation (GO:0007549)3.10675178
26proline biosynthetic process (GO:0006561)3.08907363
27stress granule assembly (GO:0034063)3.08463586
28Golgi to endosome transport (GO:0006895)3.05523020
29regulation of RNA export from nucleus (GO:0046831)3.01734528
30adherens junction assembly (GO:0034333)3.01288403
31snRNA processing (GO:0016180)3.00675345
32peptidyl-lysine dimethylation (GO:0018027)3.00388984
33focal adhesion assembly (GO:0048041)2.98682083
34cell-substrate adherens junction assembly (GO:0007045)2.98682083
35* DNA duplex unwinding (GO:0032508)2.97783618
36DNA topological change (GO:0006265)2.97400548
37protein localization to chromosome, centromeric region (GO:0071459)2.96144227
38negative regulation of histone methylation (GO:0031061)2.91982139
39histone lysine methylation (GO:0034968)2.90700226
40embryonic process involved in female pregnancy (GO:0060136)2.85766509
41cellular response to epidermal growth factor stimulus (GO:0071364)2.84440608
42corticosteroid receptor signaling pathway (GO:0031958)2.82020725
43response to epidermal growth factor (GO:0070849)2.79577025
44* DNA geometric change (GO:0032392)2.79453627
45activated T cell proliferation (GO:0050798)2.77802339
46semaphorin-plexin signaling pathway (GO:0071526)2.76987807
47establishment of spindle localization (GO:0051293)2.75923175
48nuclear pore organization (GO:0006999)2.72984689
49coronary vasculature morphogenesis (GO:0060977)2.72348516
50* positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.71291407
51histone lysine demethylation (GO:0070076)2.71126897
52histone H3-K9 methylation (GO:0051567)2.69605744
53regulation of nucleobase-containing compound transport (GO:0032239)2.68336096
54positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.65777157
55regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.65777157
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65667488
57regulation of sister chromatid cohesion (GO:0007063)2.65437453
58regulation of translational fidelity (GO:0006450)2.61995323
59positive regulation of gene expression, epigenetic (GO:0045815)2.60882989
60protein localization to microtubule (GO:0035372)2.60365244
61positive regulation of RNA splicing (GO:0033120)2.60270168
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60188987
63regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60188987
64protein export from nucleus (GO:0006611)2.58791456
65regulation of DNA endoreduplication (GO:0032875)2.55205976
66cell-substrate junction assembly (GO:0007044)2.54799921
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54133445
68regulation of histone H3-K4 methylation (GO:0051569)2.53538529
69embryonic camera-type eye morphogenesis (GO:0048596)2.51782146
70histone methylation (GO:0016571)2.51399588
71histone demethylation (GO:0016577)2.49959444
72nuclear envelope disassembly (GO:0051081)2.48731151
73membrane disassembly (GO:0030397)2.48731151
74establishment of spindle orientation (GO:0051294)2.48644603
75histone H3-K9 modification (GO:0061647)2.48195222
76histone H4-K16 acetylation (GO:0043984)2.47322043
77NLS-bearing protein import into nucleus (GO:0006607)2.45705531
78peptidyl-lysine methylation (GO:0018022)2.45555552
79pore complex assembly (GO:0046931)2.44831531
80regulation of chromatin binding (GO:0035561)2.44829228
81positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.44182104
82mitotic nuclear envelope disassembly (GO:0007077)2.43154050
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.42995786
843-UTR-mediated mRNA stabilization (GO:0070935)2.41683676
85regulation of mRNA stability (GO:0043488)2.41017903
86regulation of histone H3-K9 methylation (GO:0051570)2.40888416
87positive regulation of histone deacetylation (GO:0031065)2.40858370
88positive regulation of mRNA catabolic process (GO:0061014)2.40309589
89trophectodermal cell differentiation (GO:0001829)2.40269803
90protein localization to kinetochore (GO:0034501)2.40013928
91sister chromatid segregation (GO:0000819)2.37706372
92regulation of histone methylation (GO:0031060)2.37537962
93hippo signaling (GO:0035329)2.37288080
94cerebellar Purkinje cell differentiation (GO:0021702)2.35809017
95* DNA conformation change (GO:0071103)2.34605885
96neuron cell-cell adhesion (GO:0007158)2.34382371
97head development (GO:0060322)2.34157945
98histone H3-K9 demethylation (GO:0033169)2.32803727
99positive regulation of gamma-delta T cell activation (GO:0046645)2.32485646
100nucleosome disassembly (GO:0006337)2.31010748
101protein-DNA complex disassembly (GO:0032986)2.31010748
102central nervous system projection neuron axonogenesis (GO:0021952)2.30882884
103neural tube development (GO:0021915)2.30143364
104embryonic eye morphogenesis (GO:0048048)2.29435273
105embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27879011
106positive regulation of chromosome segregation (GO:0051984)2.27635558
107mRNA transport (GO:0051028)2.27575709
108histone H4 deacetylation (GO:0070933)2.27209374
109positive regulation by host of viral transcription (GO:0043923)2.26326433
110cytoskeleton-dependent cytokinesis (GO:0061640)2.25840329
111regulation of RNA stability (GO:0043487)2.25791057
112nucleus organization (GO:0006997)2.24611798
113protein complex localization (GO:0031503)2.24442243
114phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.24270835
115negative regulation of DNA repair (GO:0045738)2.22760694
116positive T cell selection (GO:0043368)2.22019824
117positive thymic T cell selection (GO:0045059)2.21421117
118regulation of mRNA catabolic process (GO:0061013)2.21318853
119dendritic spine morphogenesis (GO:0060997)2.21048563
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.18388694
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.17881123
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.16918464
123protein dealkylation (GO:0008214)2.16662433
124protein demethylation (GO:0006482)2.16662433
125establishment of nucleus localization (GO:0040023)2.16166393
126negative regulation of histone modification (GO:0031057)2.15564551
127RNA stabilization (GO:0043489)2.14636988
128mRNA stabilization (GO:0048255)2.14636988
129regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.14564830
130positive regulation of neurological system process (GO:0031646)2.14322568
131negative T cell selection (GO:0043383)2.13928955
132peptidyl-threonine phosphorylation (GO:0018107)2.12398447
133thymic T cell selection (GO:0045061)2.10295730
134negative thymic T cell selection (GO:0045060)2.09050470
135negative regulation of chromatin modification (GO:1903309)2.08273348
136glucocorticoid receptor signaling pathway (GO:0042921)2.07371890
137chromatin silencing (GO:0006342)2.06671045
138chromatin assembly (GO:0031497)2.06649380
139T cell selection (GO:0045058)2.05578191
140regulation of mRNA 3-end processing (GO:0031440)2.04876466
141positive regulation of mRNA processing (GO:0050685)2.04869886
142regulation of gamma-delta T cell differentiation (GO:0045586)2.04285163
143cortical actin cytoskeleton organization (GO:0030866)2.03239153
144neuronal stem cell maintenance (GO:0097150)2.02513204
145V(D)J recombination (GO:0033151)2.00424083
146positive regulation of mRNA metabolic process (GO:1903313)1.99547407
147positive regulation of histone H3-K4 methylation (GO:0051571)1.99477410
148ionotropic glutamate receptor signaling pathway (GO:0035235)1.99392175
149layer formation in cerebral cortex (GO:0021819)1.99157019
150locomotory exploration behavior (GO:0035641)1.97838653
151face morphogenesis (GO:0060325)1.97476524
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.97318215
153dendrite morphogenesis (GO:0048813)1.97293262
154peptidyl-threonine modification (GO:0018210)1.97145404
155nucleus localization (GO:0051647)1.96072317
156histone H4 acetylation (GO:0043967)1.95367490
157cortical cytoskeleton organization (GO:0030865)1.94112040
158negative regulation of mRNA processing (GO:0050686)1.93944976
159regulation of ARF protein signal transduction (GO:0032012)1.92534684
160interkinetic nuclear migration (GO:0022027)1.92306366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74077022
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.07214404
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95449505
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.68545978
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47377766
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34987521
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24797423
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20676605
9E2F7_22180533_ChIP-Seq_HELA_Human2.19289339
10* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.17107368
11GBX2_23144817_ChIP-Seq_PC3_Human2.10045325
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.04184813
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96431638
14FOXM1_23109430_ChIP-Seq_U2OS_Human1.89317608
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.88727533
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88265347
17AR_21909140_ChIP-Seq_LNCAP_Human1.87207730
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86606137
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.86024455
20MYC_22102868_ChIP-Seq_BL_Human1.83072684
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82426181
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79962270
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76116619
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.75890992
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74280342
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71580901
27VDR_21846776_ChIP-Seq_THP-1_Human1.70916685
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.68082612
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67386079
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66401702
31DROSHA_22980978_ChIP-Seq_HELA_Human1.64303746
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64253965
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.63737563
34CLOCK_20551151_ChIP-Seq_293T_Human1.63517237
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62798706
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61396687
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60344111
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60084791
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59764311
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59099612
41AR_21572438_ChIP-Seq_LNCaP_Human1.59048216
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.57491619
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57087368
44TP53_16413492_ChIP-PET_HCT116_Human1.56490015
45KDM2B_26808549_Chip-Seq_DND41_Human1.55145850
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53148657
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49350214
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49010823
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48134399
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.44794244
51CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43537221
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43497781
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.42787650
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42489934
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41877679
56CHD1_26751641_Chip-Seq_LNCaP_Human1.41498128
57AHR_22903824_ChIP-Seq_MCF-7_Human1.40707663
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.39296948
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38928985
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37751909
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37751909
62RUNX_20019798_ChIP-Seq_JUKART_Human1.37733341
63* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36827834
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35605855
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.34606787
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.33231127
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33010164
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31715925
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31218231
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29862483
71* RARB_27405468_Chip-Seq_BRAIN_Mouse1.29620091
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29193253
73SCL_19346495_ChIP-Seq_HPC-7_Human1.27876584
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27597303
75KDM2B_26808549_Chip-Seq_K562_Human1.27428472
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26282965
77* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25742432
78CIITA_25753668_ChIP-Seq_RAJI_Human1.25377071
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25068359
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25041235
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24411857
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.23870955
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.22897585
84* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22633924
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.22044810
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21644940
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21587117
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21479537
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21125776
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20444101
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.19943093
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19835991
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19831754
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19831754
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19040153
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18862537
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18787338
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18683631
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18682162
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17072315
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16974317
102STAT3_23295773_ChIP-Seq_U87_Human1.15834291
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.15137490
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14678560
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14072247
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13974789
107FUS_26573619_Chip-Seq_HEK293_Human1.13848399
108AR_19668381_ChIP-Seq_PC3_Human1.12767408
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.12755458
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12540894
111SMAD4_21799915_ChIP-Seq_A2780_Human1.11976413
112* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11695791
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09789931
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09714129
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09667613
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09297961
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08952302
118MAF_26560356_Chip-Seq_TH1_Human1.08598393
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08390590
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08344144
121MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07854812
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06950844
123TCF4_23295773_ChIP-Seq_U87_Human1.06815610
124TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05489206
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05060274
126NANOG_21062744_ChIP-ChIP_HESCs_Human1.04069906
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03634105
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.02851463
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02350429
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01892350
131POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01551871
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01202974
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01167947
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01057595
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00090342
136TCF4_18268006_ChIP-ChIP_LS174T_Human0.99602700
137JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98474600
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98364251
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97888143
140RACK7_27058665_Chip-Seq_MCF-7_Human0.97208301
141MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95637234
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94924657
143MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94339980
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94290796
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94085768
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93837730
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93237263
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92318377
149TAF15_26573619_Chip-Seq_HEK293_Human0.92151272
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.91684905
151* UTX_26944678_Chip-Seq_JUKART_Human0.91153666
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90746968
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89983358
154SOX2_21211035_ChIP-Seq_LN229_Gbm0.89836931
155EWS_26573619_Chip-Seq_HEK293_Human0.89552697
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89295154
157SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88790372
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88145962
159POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86332048
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85785210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.84389585
2MP0000569_abnormal_digit_pigmentation3.56426747
3MP0003111_abnormal_nucleus_morphology2.79597159
4MP0010352_gastrointestinal_tract_polyps2.49698947
5MP0003787_abnormal_imprinting2.44652004
6MP0003077_abnormal_cell_cycle2.21053818
7* MP0001730_embryonic_growth_arrest2.20697987
8MP0001849_ear_inflammation2.11417961
9MP0004885_abnormal_endolymph2.00628578
10MP0003566_abnormal_cell_adhesion2.00178986
11MP0004233_abnormal_muscle_weight1.99639039
12MP0008057_abnormal_DNA_replication1.96393883
13MP0003880_abnormal_central_pattern1.96298056
14MP0002009_preneoplasia1.89451385
15MP0003121_genomic_imprinting1.88852294
16MP0004859_abnormal_synaptic_plasticity1.88836629
17MP0005257_abnormal_intraocular_pressure1.84344658
18MP0000778_abnormal_nervous_system1.83245086
19MP0005076_abnormal_cell_differentiation1.81819707
20MP0003984_embryonic_growth_retardation1.80026678
21MP0001672_abnormal_embryogenesis/_devel1.79440231
22MP0005380_embryogenesis_phenotype1.79440231
23MP0002877_abnormal_melanocyte_morpholog1.75438550
24MP0005409_darkened_coat_color1.73094786
25MP0003890_abnormal_embryonic-extraembry1.72726843
26MP0002088_abnormal_embryonic_growth/wei1.72030066
27* MP0004957_abnormal_blastocyst_morpholog1.70823482
28MP0003693_abnormal_embryo_hatching1.64701893
29MP0009672_abnormal_birth_weight1.63039911
30MP0001915_intracranial_hemorrhage1.61156332
31MP0002086_abnormal_extraembryonic_tissu1.59238832
32MP0005174_abnormal_tail_pigmentation1.58914213
33MP0004264_abnormal_extraembryonic_tissu1.56058854
34MP0005499_abnormal_olfactory_system1.54953496
35MP0005394_taste/olfaction_phenotype1.54953496
36MP0008932_abnormal_embryonic_tissue1.52790772
37MP0001346_abnormal_lacrimal_gland1.51442899
38MP0006072_abnormal_retinal_apoptosis1.49476354
39MP0003045_fibrosis1.47389603
40MP0003385_abnormal_body_wall1.42892961
41MP0000537_abnormal_urethra_morphology1.42137310
42MP0003122_maternal_imprinting1.41024782
43* MP0002080_prenatal_lethality1.39079867
44MP0000428_abnormal_craniofacial_morphol1.38651488
45MP0002166_altered_tumor_susceptibility1.35987223
46MP0003763_abnormal_thymus_physiology1.35682022
47MP0001697_abnormal_embryo_size1.34871572
48MP0005423_abnormal_somatic_nervous1.34847102
49MP0008877_abnormal_DNA_methylation1.33283954
50MP0000733_abnormal_muscle_development1.32825042
51MP0003861_abnormal_nervous_system1.30794160
52MP0008007_abnormal_cellular_replicative1.29867979
53MP0003635_abnormal_synaptic_transmissio1.29385812
54MP0001486_abnormal_startle_reflex1.28673732
55MP0005551_abnormal_eye_electrophysiolog1.28085897
56MP0003937_abnormal_limbs/digits/tail_de1.27503063
57MP0010234_abnormal_vibrissa_follicle1.26482658
58MP0003941_abnormal_skin_development1.25711484
59MP0005621_abnormal_cell_physiology1.23633331
60MP0005451_abnormal_body_composition1.21852556
61MP0003935_abnormal_craniofacial_develop1.20757086
62MP0009053_abnormal_anal_canal1.20527937
63MP0004742_abnormal_vestibular_system1.20515839
64MP0010630_abnormal_cardiac_muscle1.19533028
65MP0002396_abnormal_hematopoietic_system1.19165690
66MP0006292_abnormal_olfactory_placode1.18623703
67MP0008789_abnormal_olfactory_epithelium1.18312426
68MP0010368_abnormal_lymphatic_system1.15976929
69MP0000703_abnormal_thymus_morphology1.15591672
70MP0000383_abnormal_hair_follicle1.15461422
71MP0003942_abnormal_urinary_system1.14190149
72MP0003315_abnormal_perineum_morphology1.13999729
73MP0005623_abnormal_meninges_morphology1.12815888
74* MP0002084_abnormal_developmental_patter1.11607098
75MP0010678_abnormal_skin_adnexa1.11121287
76MP0002152_abnormal_brain_morphology1.08530546
77MP0000432_abnormal_head_morphology1.05808939
78MP0008569_lethality_at_weaning1.05428731
79MP0004858_abnormal_nervous_system1.05151593
80MP0000631_abnormal_neuroendocrine_gland1.04981071
81MP0004197_abnormal_fetal_growth/weight/1.04759405
82MP0003453_abnormal_keratinocyte_physiol1.04584045
83MP0000015_abnormal_ear_pigmentation1.03723879
84MP0004808_abnormal_hematopoietic_stem1.02251203
85MP0002882_abnormal_neuron_morphology1.00670529
86MP0004270_analgesia0.98583241
87MP0003091_abnormal_cell_migration0.98232722
88MP0002184_abnormal_innervation0.97751863
89MP0005666_abnormal_adipose_tissue0.97630961
90MP0000579_abnormal_nail_morphology0.97027950
91MP0009703_decreased_birth_body0.96690062
92MP0003115_abnormal_respiratory_system0.95632557
93* MP0002085_abnormal_embryonic_tissue0.95620693
94MP0005187_abnormal_penis_morphology0.94976652
95MP0003123_paternal_imprinting0.94517427
96MP0004185_abnormal_adipocyte_glucose0.94090685
97MP0003136_yellow_coat_color0.93354907
98MP0005253_abnormal_eye_physiology0.92778649
99MP0000955_abnormal_spinal_cord0.92207848
100MP0003303_peritoneal_inflammation0.92107359
101MP0004145_abnormal_muscle_electrophysio0.91899305
102MP0009046_muscle_twitch0.90996230
103MP0000762_abnormal_tongue_morphology0.90183469
104MP0008995_early_reproductive_senescence0.89977979
105MP0002089_abnormal_postnatal_growth/wei0.89934610
106MP0005384_cellular_phenotype0.89769216
107MP0008260_abnormal_autophagy0.89335966
108MP0002697_abnormal_eye_size0.89208000
109MP0004272_abnormal_basement_membrane0.88187399
110MP0002006_tumorigenesis0.87914822
111MP0000313_abnormal_cell_death0.87722243
112MP0009745_abnormal_behavioral_response0.86970683
113MP0009278_abnormal_bone_marrow0.86804950
114MP0002064_seizures0.86798020
115MP0003300_gastrointestinal_ulcer0.86631147
116MP0003755_abnormal_palate_morphology0.86560114
117MP0003943_abnormal_hepatobiliary_system0.86409414
118MP0002796_impaired_skin_barrier0.86212560
119MP0005391_vision/eye_phenotype0.86135876
120MP0005195_abnormal_posterior_eye0.85829244
121MP0003221_abnormal_cardiomyocyte_apopto0.85701230
122MP0002557_abnormal_social/conspecific_i0.85028475
123MP0002081_perinatal_lethality0.84865154
124MP0002572_abnormal_emotion/affect_behav0.83923820
125MP0001286_abnormal_eye_development0.83875415
126MP0001348_abnormal_lacrimal_gland0.83826084
127MP0002063_abnormal_learning/memory/cond0.82993310
128MP0008058_abnormal_DNA_repair0.82960778
129MP0000920_abnormal_myelination0.82817182
130MP0002116_abnormal_craniofacial_bone0.82586547
131MP0002092_abnormal_eye_morphology0.81259369
132MP0002114_abnormal_axial_skeleton0.79874327
133MP0001299_abnormal_eye_distance/0.79657628
134MP0001800_abnormal_humoral_immune0.79570894
135MP0002925_abnormal_cardiovascular_devel0.79357375
136MP0010307_abnormal_tumor_latency0.79189992
137MP0005501_abnormal_skin_physiology0.78389485
138MP0002398_abnormal_bone_marrow0.78269626
139MP0005375_adipose_tissue_phenotype0.78090180
140MP0000566_synostosis0.77749851
141MP0002098_abnormal_vibrissa_morphology0.77130603
142MP0003632_abnormal_nervous_system0.76650221
143MP0003634_abnormal_glial_cell0.76305184
144MP0002752_abnormal_somatic_nervous0.75746242
145MP0000767_abnormal_smooth_muscle0.75524777
146MP0004381_abnormal_hair_follicle0.75521759
147MP0000627_abnormal_mammary_gland0.75462589
148MP0002177_abnormal_outer_ear0.75148490
149MP0002067_abnormal_sensory_capabilities0.74969282
150MP0010094_abnormal_chromosome_stability0.74271226
151MP0003938_abnormal_ear_development0.73001986
152MP0000350_abnormal_cell_proliferation0.72952491
153MP0004134_abnormal_chest_morphology0.72053501
154MP0002233_abnormal_nose_morphology0.71189695
155MP0008770_decreased_survivor_rate0.70796699
156MP0008961_abnormal_basal_metabolism0.70674072

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.57938876
2Volvulus (HP:0002580)3.11647880
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96641497
4Short 4th metacarpal (HP:0010044)2.96641497
5Macroorchidism (HP:0000053)2.61945678
6Heterotopia (HP:0002282)2.47978241
7Narrow palate (HP:0000189)2.45732539
8Flat acetabular roof (HP:0003180)2.44926773
9Hepatoblastoma (HP:0002884)2.42853363
10Congenital stationary night blindness (HP:0007642)2.39469205
11Subacute progressive viral hepatitis (HP:0006572)2.37890168
12Polygenic inheritance (HP:0010982)2.36850514
13Long eyelashes (HP:0000527)2.34634126
14Supernumerary ribs (HP:0005815)2.32036803
15Disinhibition (HP:0000734)2.30107845
16Inappropriate behavior (HP:0000719)2.28011753
17Deep philtrum (HP:0002002)2.27635492
18Toxemia of pregnancy (HP:0100603)2.23389195
19Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.23338472
20Absent frontal sinuses (HP:0002688)2.22587319
21Trigonocephaly (HP:0000243)2.20353217
22Broad face (HP:0000283)2.18840486
23Hyperacusis (HP:0010780)2.14823572
24Neonatal hypoglycemia (HP:0001998)2.14143365
25Asymmetry of the thorax (HP:0001555)2.14039925
26Nephroblastoma (Wilms tumor) (HP:0002667)2.12020844
27Abnormality of the nasal septum (HP:0000419)2.11101092
28Malignant gastrointestinal tract tumors (HP:0006749)2.09170280
29Gastrointestinal carcinoma (HP:0002672)2.09170280
30Drooling (HP:0002307)2.05813773
31Excessive salivation (HP:0003781)2.05813773
32Ulnar bowing (HP:0003031)2.05038994
33Ectopic kidney (HP:0000086)2.03811818
34Abnormality of the 4th metacarpal (HP:0010012)2.03343544
35Rhabdomyosarcoma (HP:0002859)2.02701482
36Obsessive-compulsive behavior (HP:0000722)2.02645886
37Anal stenosis (HP:0002025)2.02508798
38Action tremor (HP:0002345)1.98214465
39Urethral obstruction (HP:0000796)1.96742190
40Increased nuchal translucency (HP:0010880)1.96658578
41Genetic anticipation (HP:0003743)1.96049387
42Broad palm (HP:0001169)1.94856735
43Embryonal renal neoplasm (HP:0011794)1.94855405
44Vertebral arch anomaly (HP:0008438)1.94240990
45Abnormality of the astrocytes (HP:0100707)1.93060450
46Astrocytoma (HP:0009592)1.93060450
47Supernumerary bones of the axial skeleton (HP:0009144)1.92048211
48High anterior hairline (HP:0009890)1.91959461
49Papillary thyroid carcinoma (HP:0002895)1.91330306
50Abnormality of binocular vision (HP:0011514)1.89661079
51Diplopia (HP:0000651)1.89661079
52Progressive cerebellar ataxia (HP:0002073)1.88107506
53Aqueductal stenosis (HP:0002410)1.87523984
54Shallow orbits (HP:0000586)1.87244693
55Neoplasm of the oral cavity (HP:0100649)1.85763903
56Skull defect (HP:0001362)1.85376167
57Medulloblastoma (HP:0002885)1.85268577
58Abnormality of the labia minora (HP:0012880)1.84866466
59Agammaglobulinemia (HP:0004432)1.84777475
60Hand muscle atrophy (HP:0009130)1.84696629
61Midline defect of the nose (HP:0004122)1.83943768
62Ankyloglossia (HP:0010296)1.83643844
63Disproportionate tall stature (HP:0001519)1.83402864
64Oligodactyly (hands) (HP:0001180)1.80540566
65Truncal obesity (HP:0001956)1.78893706
66Prominent nose (HP:0000448)1.78761211
67Deep palmar crease (HP:0006191)1.77602185
68Germ cell neoplasia (HP:0100728)1.77327978
69Sandal gap (HP:0001852)1.76761309
70Distal upper limb amyotrophy (HP:0007149)1.76133262
71Upper limb amyotrophy (HP:0009129)1.76133262
72Overriding aorta (HP:0002623)1.75486252
73Arnold-Chiari malformation (HP:0002308)1.74612667
74Diastasis recti (HP:0001540)1.74189171
75Sparse lateral eyebrow (HP:0005338)1.73885796
76Broad thumb (HP:0011304)1.73527698
77Thyroiditis (HP:0100646)1.73457181
78Lip pit (HP:0100267)1.71385529
79Smooth philtrum (HP:0000319)1.71118831
80Advanced eruption of teeth (HP:0006288)1.70610492
81Renal cell carcinoma (HP:0005584)1.69393571
82Capillary hemangiomas (HP:0005306)1.69136901
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68830199
84T lymphocytopenia (HP:0005403)1.68008452
85Ureteral stenosis (HP:0000071)1.67764013
86Abnormality of chromosome segregation (HP:0002916)1.67470797
87Cafe-au-lait spot (HP:0000957)1.66484161
88Abnormality of the thoracic spine (HP:0100711)1.66291810
89Widely spaced teeth (HP:0000687)1.64712575
90Hypoplasia of the maxilla (HP:0000327)1.63700218
91Abnormality of the phalanges of the hallux (HP:0010057)1.63499709
92Mitral valve prolapse (HP:0001634)1.62828884
93Oligodontia (HP:0000677)1.62486763
94Elfin facies (HP:0004428)1.61568147
95Ependymoma (HP:0002888)1.61560184
96Gaze-evoked nystagmus (HP:0000640)1.61142851
97Chin dimple (HP:0010751)1.61106138
98Transitional cell carcinoma of the bladder (HP:0006740)1.60705695
99Limited elbow extension (HP:0001377)1.60529762
100Missing ribs (HP:0000921)1.59809701
101Ureteral obstruction (HP:0006000)1.59787055
102Attention deficit hyperactivity disorder (HP:0007018)1.59674675
103Large earlobe (HP:0009748)1.59228486
104Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58526411
105Chromsome breakage (HP:0040012)1.57715396
106Broad phalanges of the hand (HP:0009768)1.57582543
107Proximal placement of thumb (HP:0009623)1.57576993
108Abnormality of the humeroradial joint (HP:0100744)1.57034573
109Abnormality of the diencephalon (HP:0010662)1.56719097
110Low anterior hairline (HP:0000294)1.56696270
111Persistence of primary teeth (HP:0006335)1.56620894
112Thick eyebrow (HP:0000574)1.56594612
113Dysmetric saccades (HP:0000641)1.56472987
114Insidious onset (HP:0003587)1.56308365
115Termporal pattern (HP:0011008)1.56308365
116Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56276742
117Wide nose (HP:0000445)1.56179393
118Cubitus valgus (HP:0002967)1.55065907
119Renovascular hypertension (HP:0100817)1.54905129
120Pseudobulbar signs (HP:0002200)1.54755938
121Panhypogammaglobulinemia (HP:0003139)1.54625623
122Overgrowth (HP:0001548)1.53647102
123Acute myeloid leukemia (HP:0004808)1.53297198
124Cerebral aneurysm (HP:0004944)1.53207238
125Obstructive sleep apnea (HP:0002870)1.52934698
126Glioma (HP:0009733)1.52868781
127Neuroblastoma (HP:0003006)1.52704816
128Primitive neuroectodermal tumor (HP:0030065)1.52704816
129Neuroblastic tumors (HP:0004376)1.52704816
130Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.52704816
131Precocious puberty (HP:0000826)1.52542615
132Hammertoe (HP:0001765)1.52449590
133Deviation of the thumb (HP:0009603)1.52234623
134Spina bifida occulta (HP:0003298)1.51375724
135Renal duplication (HP:0000075)1.50749097
136Pointed chin (HP:0000307)1.50414942
137Abnormality of the parietal bone (HP:0002696)1.50075154
138Uterine leiomyosarcoma (HP:0002891)1.49975732
139Leiomyosarcoma (HP:0100243)1.49975732
140Dislocated radial head (HP:0003083)1.48609437
141Sacral dimple (HP:0000960)1.48602819
142Flat cornea (HP:0007720)1.48063229
143Broad-based gait (HP:0002136)1.47860207
144Impaired smooth pursuit (HP:0007772)1.45558895
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.45079471
146Syringomyelia (HP:0003396)1.44685102
147Spinal cord lesions (HP:0100561)1.44685102
148Oligodactyly (HP:0012165)1.44464821
149Urinary bladder sphincter dysfunction (HP:0002839)1.44349112
150Depressed nasal tip (HP:0000437)1.43830313
151Neoplasm of striated muscle (HP:0009728)1.43727322
152Anteriorly placed anus (HP:0001545)1.43061051
153Abnormality of T cell number (HP:0011839)1.42932827
154Vesicoureteral reflux (HP:0000076)1.41331332
155Abnormality of the radial head (HP:0003995)1.41212972
156Bladder carcinoma (HP:0002862)1.41046950
157Bladder neoplasm (HP:0009725)1.41046950
158Patellar dislocation (HP:0002999)1.40601928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.63805581
2CAMK1G3.27686446
3SMG13.07172119
4BRD42.73403689
5FGFR42.66671224
6SIK22.64805224
7PNCK2.58411391
8CAMK1D2.56546840
9EEF2K1.99899840
10MKNK21.99341046
11MAP4K11.75544443
12TYRO31.75241948
13ICK1.69160172
14LATS11.66746899
15MAP3K101.58237809
16FGFR21.56418002
17WNK11.55134730
18TNIK1.54524594
19SIK11.43899921
20PDGFRB1.39988923
21MKNK11.37922000
22SCYL21.37143453
23TAF11.35793954
24FES1.35067227
25MARK21.31755286
26CDC71.28813847
27MAP3K41.25841600
28NEK21.23163564
29ALK1.21742992
30NTRK21.20695210
31CDK61.19767710
32CSNK1A1L1.17720842
33TTK1.17288080
34CDK91.16499457
35TSSK61.16438753
36CLK11.10909785
37MAPK131.06602324
38UHMK11.05687111
39MAP3K71.04022876
40MARK11.03969274
41CDK71.03702044
42LATS21.02937724
43PRKD21.02587665
44MTOR1.01009625
45RPS6KB21.00482381
46TAOK11.00346039
47NTRK30.98572463
48HIPK20.97860762
49RIPK40.94070927
50CDK30.93084666
51HCK0.92088724
52CSNK1D0.89765092
53CDC42BPA0.89513858
54PRPF4B0.89428313
55CDK40.89371368
56NEK60.87342378
57PDGFRA0.86292338
58RIPK10.84353240
59MAP3K130.82508801
60AKT30.82011960
61PRKCH0.81571206
62PKN10.80804128
63PAK60.80436456
64TNK20.80336657
65CSNK1G10.80036027
66ATM0.79172157
67KSR20.78593317
68CSNK1G20.78419216
69FGR0.78155858
70CHEK10.76693138
71SGK10.76585075
72SGK4940.75962310
73SGK2230.75962310
74TTN0.74651147
75ITK0.73577719
76SGK30.71696990
77MAP3K90.71483793
78FGFR30.71030022
79PKN20.70125021
80STK110.69238311
81PASK0.68578984
82MAPK140.67252580
83YES10.66118238
84PRKD30.65964460
85PRKDC0.65139004
86ERBB20.65018681
87RET0.64546648
88GRK60.64472098
89GSK3B0.63171129
90MAPK100.62782538
91CSNK1G30.62517405
92EPHB10.62414658
93PTK60.62197849
94CDK20.62033301
95ERN10.60322334
96LCK0.59451824
97CSK0.59204399
98FGFR10.59160191
99CDK10.57827036
100STK100.57295000
101KSR10.57248641
102CSNK1E0.56220796
103FYN0.55529090
104CAMK40.55238680
105SRPK10.55236551
106PTK20.54890677
107TRIB30.54475993
108MELK0.54464066
109PAK20.54354108
110ATR0.53628656
111DYRK1A0.52770588
112SGK20.52661756
113CSF1R0.52650399
114STK390.52459248
115MAPK80.52407470
116STK380.52026757
117NLK0.51489570
118MAPK110.51368563
119NEK90.50721023
120BMX0.50209530
121CHEK20.49599256
122RPS6KB10.49596798
123EPHB20.49460896
124PRKAA20.49084878
125MAP3K60.49003085
126NTRK10.46337406
127DMPK0.46239323
128MAPK70.45531146
129STK40.44985820
130TXK0.43765983
131BTK0.43383605
132MAP3K20.43234208
133MAP3K80.42622717
134MAP3K140.41244623
135JAK10.39587423
136AKT10.35980783
137PRKAA10.35434838
138BRAF0.34236003
139LRRK20.33464299
140RPS6KA10.32571667
141PIK3CA0.32556471

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052161.91032914
2Phototransduction_Homo sapiens_hsa047441.81463834
3Cell cycle_Homo sapiens_hsa041101.58377553
4Primary immunodeficiency_Homo sapiens_hsa053401.46813577
5Nicotine addiction_Homo sapiens_hsa050331.46811607
6B cell receptor signaling pathway_Homo sapiens_hsa046621.40739656
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.36873506
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35605880
9T cell receptor signaling pathway_Homo sapiens_hsa046601.34942268
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33454312
11Axon guidance_Homo sapiens_hsa043601.32871853
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32611676
13Viral carcinogenesis_Homo sapiens_hsa052031.32379315
14Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29424173
15MicroRNAs in cancer_Homo sapiens_hsa052061.28611373
16Lysine degradation_Homo sapiens_hsa003101.28118565
17Glutamatergic synapse_Homo sapiens_hsa047241.25846994
18Basal cell carcinoma_Homo sapiens_hsa052171.25128474
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23783197
20Chronic myeloid leukemia_Homo sapiens_hsa052201.22818330
21Colorectal cancer_Homo sapiens_hsa052101.21141281
22mRNA surveillance pathway_Homo sapiens_hsa030151.20999182
23Dorso-ventral axis formation_Homo sapiens_hsa043201.19579767
24Notch signaling pathway_Homo sapiens_hsa043301.19013915
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18707955
26Bladder cancer_Homo sapiens_hsa052191.18630647
27Long-term potentiation_Homo sapiens_hsa047201.17118451
28Type II diabetes mellitus_Homo sapiens_hsa049301.16510400
29Spliceosome_Homo sapiens_hsa030401.16030882
30Insulin signaling pathway_Homo sapiens_hsa049101.14623912
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12699196
32Morphine addiction_Homo sapiens_hsa050321.11984650
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10779417
34Renal cell carcinoma_Homo sapiens_hsa052111.08789378
35ErbB signaling pathway_Homo sapiens_hsa040121.08749085
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08632552
37Endometrial cancer_Homo sapiens_hsa052131.08149047
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06513589
39Non-small cell lung cancer_Homo sapiens_hsa052231.06483012
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05471106
41mTOR signaling pathway_Homo sapiens_hsa041501.03851516
42Long-term depression_Homo sapiens_hsa047301.03770762
43Glioma_Homo sapiens_hsa052141.02966445
44* Wnt signaling pathway_Homo sapiens_hsa043101.02346254
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01542054
46Cholinergic synapse_Homo sapiens_hsa047251.01159994
47Salivary secretion_Homo sapiens_hsa049701.00223179
48Renin secretion_Homo sapiens_hsa049240.99320264
49Dopaminergic synapse_Homo sapiens_hsa047280.98656760
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.98052995
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97970820
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97739881
53Prostate cancer_Homo sapiens_hsa052150.97384285
54RNA transport_Homo sapiens_hsa030130.96592440
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96544545
56DNA replication_Homo sapiens_hsa030300.96380672
57Pancreatic cancer_Homo sapiens_hsa052120.96291604
58Choline metabolism in cancer_Homo sapiens_hsa052310.95816445
59Circadian entrainment_Homo sapiens_hsa047130.95793258
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95537110
61Estrogen signaling pathway_Homo sapiens_hsa049150.94673509
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93297927
63Oxytocin signaling pathway_Homo sapiens_hsa049210.91304188
64Adherens junction_Homo sapiens_hsa045200.90126911
65GnRH signaling pathway_Homo sapiens_hsa049120.90092568
66MAPK signaling pathway_Homo sapiens_hsa040100.90075802
67Inositol phosphate metabolism_Homo sapiens_hsa005620.89983721
68GABAergic synapse_Homo sapiens_hsa047270.89276058
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.89168805
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88903959
71Melanogenesis_Homo sapiens_hsa049160.88056392
72Hedgehog signaling pathway_Homo sapiens_hsa043400.86667825
73Chemokine signaling pathway_Homo sapiens_hsa040620.86517777
74Proteoglycans in cancer_Homo sapiens_hsa052050.86265826
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85622825
76Platelet activation_Homo sapiens_hsa046110.84984527
77Hippo signaling pathway_Homo sapiens_hsa043900.84964898
78Non-homologous end-joining_Homo sapiens_hsa034500.84879738
79HIF-1 signaling pathway_Homo sapiens_hsa040660.83855903
80Olfactory transduction_Homo sapiens_hsa047400.83648453
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83583756
82Osteoclast differentiation_Homo sapiens_hsa043800.83524556
83Gastric acid secretion_Homo sapiens_hsa049710.83379282
84Small cell lung cancer_Homo sapiens_hsa052220.83073312
85cAMP signaling pathway_Homo sapiens_hsa040240.82664381
86Tight junction_Homo sapiens_hsa045300.82635928
87Viral myocarditis_Homo sapiens_hsa054160.82623846
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80931458
89Apoptosis_Homo sapiens_hsa042100.80564612
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80277773
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79776787
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.79598393
93Acute myeloid leukemia_Homo sapiens_hsa052210.79481620
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79285600
95Hepatitis C_Homo sapiens_hsa051600.78723714
96Rap1 signaling pathway_Homo sapiens_hsa040150.78323625
97Pathways in cancer_Homo sapiens_hsa052000.78025066
98AMPK signaling pathway_Homo sapiens_hsa041520.77982269
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77808836
100Focal adhesion_Homo sapiens_hsa045100.77790404
101HTLV-I infection_Homo sapiens_hsa051660.76733565
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.76288292
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75048932
104Taste transduction_Homo sapiens_hsa047420.74290082
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.72178320
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72055090
107Melanoma_Homo sapiens_hsa052180.71981441
108Influenza A_Homo sapiens_hsa051640.71771318
109VEGF signaling pathway_Homo sapiens_hsa043700.71710910
110TGF-beta signaling pathway_Homo sapiens_hsa043500.71216506
111Amoebiasis_Homo sapiens_hsa051460.71080664
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70781137
113Hepatitis B_Homo sapiens_hsa051610.70697034
114Mismatch repair_Homo sapiens_hsa034300.70549045
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70386201
116Gap junction_Homo sapiens_hsa045400.70206269
117FoxO signaling pathway_Homo sapiens_hsa040680.68798451
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68732718
119Alcoholism_Homo sapiens_hsa050340.67769315
120Amphetamine addiction_Homo sapiens_hsa050310.67565488
121Cocaine addiction_Homo sapiens_hsa050300.66194553
122ECM-receptor interaction_Homo sapiens_hsa045120.66104535
123Prolactin signaling pathway_Homo sapiens_hsa049170.65956034
124Measles_Homo sapiens_hsa051620.65694440
125Insulin resistance_Homo sapiens_hsa049310.65338713
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65249457
127Calcium signaling pathway_Homo sapiens_hsa040200.64891245
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63841054
129p53 signaling pathway_Homo sapiens_hsa041150.62994095
130Epstein-Barr virus infection_Homo sapiens_hsa051690.61942207
131Herpes simplex infection_Homo sapiens_hsa051680.61494196
132Systemic lupus erythematosus_Homo sapiens_hsa053220.60743743
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59365404
134Glucagon signaling pathway_Homo sapiens_hsa049220.56226282
135Toxoplasmosis_Homo sapiens_hsa051450.54850690
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50970334

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »