CHD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)5.88538610
2antigen processing and presentation of endogenous antigen (GO:0019883)4.75913512
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59647455
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59647455
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39911655
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.37323255
7hypotonic response (GO:0006971)4.34650208
8pyrimidine nucleobase catabolic process (GO:0006208)4.33587014
9L-serine transport (GO:0015825)4.32430463
10serine transport (GO:0032329)4.26784859
11presynaptic membrane assembly (GO:0097105)3.92390411
12positive regulation of gamma-delta T cell activation (GO:0046645)3.71324949
13mannose metabolic process (GO:0006013)3.64636811
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59234724
15neural tube formation (GO:0001841)3.56354011
16interkinetic nuclear migration (GO:0022027)3.54105348
17nucleobase catabolic process (GO:0046113)3.53535458
18presynaptic membrane organization (GO:0097090)3.52216604
19establishment of protein localization to Golgi (GO:0072600)3.39061511
20behavioral response to nicotine (GO:0035095)3.38909681
21Golgi transport vesicle coating (GO:0048200)3.35273493
22COPI coating of Golgi vesicle (GO:0048205)3.35273493
23negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35020430
24positive regulation of B cell differentiation (GO:0045579)3.32202671
25epithelial cilium movement (GO:0003351)3.30570002
26cell adhesion mediated by integrin (GO:0033627)3.25142125
27regulation of gamma-delta T cell differentiation (GO:0045586)3.12570320
28microtubule anchoring (GO:0034453)3.12153048
29hemidesmosome assembly (GO:0031581)3.11319439
30B cell receptor signaling pathway (GO:0050853)3.10580821
31centriole replication (GO:0007099)3.08668312
32regulation of superoxide anion generation (GO:0032928)3.08426413
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07817687
34regulation of alkaline phosphatase activity (GO:0010692)3.06922821
35regulation of pigment cell differentiation (GO:0050932)3.06476064
36axonal fasciculation (GO:0007413)3.06436212
37regulation of cilium movement (GO:0003352)3.05866142
38negative regulation of neurotransmitter transport (GO:0051589)3.04335769
39protein polyglutamylation (GO:0018095)3.03490415
40beta-amyloid metabolic process (GO:0050435)3.00872266
41postsynaptic membrane organization (GO:0001941)2.98577752
42protein targeting to Golgi (GO:0000042)2.96994945
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.95663188
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94772428
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.94772428
46regulation of translation, ncRNA-mediated (GO:0045974)2.94772428
47antigen processing and presentation via MHC class Ib (GO:0002475)2.93213812
48intestinal epithelial cell development (GO:0060576)2.90881087
49valine metabolic process (GO:0006573)2.90209295
50epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89720614
51cilium organization (GO:0044782)2.89463342
52auditory behavior (GO:0031223)2.89290112
53central nervous system projection neuron axonogenesis (GO:0021952)2.88997058
54cilium movement (GO:0003341)2.88028610
55regulation of cholesterol homeostasis (GO:2000188)2.87879872
56regulation of interferon-beta biosynthetic process (GO:0045357)2.87036963
57cilium assembly (GO:0042384)2.86719862
58central nervous system neuron axonogenesis (GO:0021955)2.86558894
59limb bud formation (GO:0060174)2.84814592
60pentose-phosphate shunt (GO:0006098)2.84215713
61cysteine metabolic process (GO:0006534)2.84212518
62positive regulation of histone deacetylation (GO:0031065)2.83133142
63mesodermal cell differentiation (GO:0048333)2.81735233
64regulation of gamma-delta T cell activation (GO:0046643)2.81499046
65mechanosensory behavior (GO:0007638)2.81330769
66positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.81251287
67cerebral cortex radially oriented cell migration (GO:0021799)2.80559616
68protein retention in ER lumen (GO:0006621)2.80247380
69growth hormone receptor signaling pathway (GO:0060396)2.79594211
70intraciliary transport (GO:0042073)2.79112661
71startle response (GO:0001964)2.78957425
72nonmotile primary cilium assembly (GO:0035058)2.78749940
73appendage development (GO:0048736)2.78319505
74limb development (GO:0060173)2.78319505
75neuronal action potential (GO:0019228)2.77896765
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77157511
77negative regulation of neurotransmitter secretion (GO:0046929)2.76329402
78retinal ganglion cell axon guidance (GO:0031290)2.76224298
79cilium morphogenesis (GO:0060271)2.75509834
80nucleus localization (GO:0051647)2.72753322
81negative regulation of B cell proliferation (GO:0030889)2.72707914
82positive regulation of protein localization to plasma membrane (GO:1903078)2.72541650
83histone H3-K4 trimethylation (GO:0080182)2.71873010
84hindbrain development (GO:0030902)2.71152343
85photoreceptor cell maintenance (GO:0045494)2.71096947
86axoneme assembly (GO:0035082)2.69966054
87neuron recognition (GO:0008038)2.69912514
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69763455
89neuron cell-cell adhesion (GO:0007158)2.69459458
90glial cell proliferation (GO:0014009)2.68830325
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.68458557
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.67214955
93activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66697595
94otic vesicle formation (GO:0030916)2.65568973
95retina layer formation (GO:0010842)2.65006654
96lung epithelium development (GO:0060428)2.63485106
97peptide catabolic process (GO:0043171)2.62556029
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.61708303
99behavioral response to ethanol (GO:0048149)2.60829541
100hepatocyte differentiation (GO:0070365)2.60039309
101response to pheromone (GO:0019236)2.59713804
102positive regulation of nuclease activity (GO:0032075)2.59281088
103regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58899998
104somite development (GO:0061053)2.58815708
105prenylation (GO:0097354)2.58638841
106protein prenylation (GO:0018342)2.58638841
107gamma-aminobutyric acid transport (GO:0015812)2.58194484
108pancreas development (GO:0031016)2.57632943
109protein localization to Golgi apparatus (GO:0034067)2.57192190
110cilium or flagellum-dependent cell motility (GO:0001539)2.56329115
111angiotensin maturation (GO:0002003)2.56138781
112regulation of sarcomere organization (GO:0060297)2.54933407
113transcytosis (GO:0045056)2.54311586
114N-glycan processing (GO:0006491)2.54268452
115regulation of telomere maintenance (GO:0032204)2.54119952
116positive regulation of developmental pigmentation (GO:0048087)2.54036079
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53260359
118cell proliferation in forebrain (GO:0021846)2.51641420
119skin morphogenesis (GO:0043589)2.50942977
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.49813265
121cellular component assembly involved in morphogenesis (GO:0010927)2.49764991
122olfactory bulb development (GO:0021772)2.48665008
123dendritic spine morphogenesis (GO:0060997)2.48276265
124regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48193053
125negative regulation of axon guidance (GO:1902668)2.48164154
126replication fork processing (GO:0031297)2.48028450
127NADPH regeneration (GO:0006740)2.47298037
128transepithelial transport (GO:0070633)2.46221025
129positive regulation of cellular amide metabolic process (GO:0034250)2.46092896
130regulation of B cell differentiation (GO:0045577)2.45588898
131ionotropic glutamate receptor signaling pathway (GO:0035235)2.44753035
132glutamate receptor signaling pathway (GO:0007215)2.44542562
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44110400
134endoplasmic reticulum unfolded protein response (GO:0030968)2.43518257
135I-kappaB phosphorylation (GO:0007252)2.43152155
136protein K11-linked deubiquitination (GO:0035871)2.42852014
137cellular modified amino acid catabolic process (GO:0042219)2.42701931
138head development (GO:0060322)2.41380122
139cellular response to growth hormone stimulus (GO:0071378)2.41142776
140positive regulation of phagocytosis (GO:0050766)2.40374375
141regulation of interleukin-12 biosynthetic process (GO:0045075)2.40088740
142kidney morphogenesis (GO:0060993)2.39844506
143negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39433298
144spinal cord development (GO:0021510)2.39126921
145serotonin metabolic process (GO:0042428)2.38771912
146brain morphogenesis (GO:0048854)2.38457807
147apoptotic cell clearance (GO:0043277)2.38131003
148detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38059347
149regulation of nuclease activity (GO:0032069)2.37200298
150dendrite morphogenesis (GO:0048813)2.35844813
151protein localization to cilium (GO:0061512)2.35785249
152Sertoli cell development (GO:0060009)2.35031529
153artery development (GO:0060840)2.34363823
154regulation of natural killer cell differentiation (GO:0032823)2.34256719
155complement activation, classical pathway (GO:0006958)2.33769447
156establishment of endothelial barrier (GO:0061028)2.33472854
157cyclic nucleotide catabolic process (GO:0009214)2.33148056
158cellular response to unfolded protein (GO:0034620)2.33020953
159sulfur amino acid catabolic process (GO:0000098)2.32933643
160dentate gyrus development (GO:0021542)2.32625329
161renal tubule morphogenesis (GO:0061333)2.32522680
162retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31635545
163renal filtration (GO:0097205)2.31308118
164macrophage activation involved in immune response (GO:0002281)2.31195271
165neutrophil activation involved in immune response (GO:0002283)2.31089071
166regulation of phagocytosis (GO:0050764)2.30655577
167peptidyl-lysine trimethylation (GO:0018023)2.30475604
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30376714
169ER-nucleus signaling pathway (GO:0006984)2.30310986
170neutrophil activation (GO:0042119)2.29875930
171hormone catabolic process (GO:0042447)2.29805276
172photoreceptor cell development (GO:0042461)2.29646105
173cytoplasmic mRNA processing body assembly (GO:0033962)2.28177812
174monoubiquitinated protein deubiquitination (GO:0035520)2.27677312
175cAMP catabolic process (GO:0006198)2.26961496
176regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26529626
177regulation of axon guidance (GO:1902667)2.24725940
178regulation of action potential (GO:0098900)2.24523233
179negative regulation of mast cell activation (GO:0033004)2.23634756
180phospholipid scrambling (GO:0017121)2.22705281
181reverse cholesterol transport (GO:0043691)2.22244614
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.22074384
183natural killer cell differentiation (GO:0001779)2.21975810
184fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.21592424
185membrane depolarization during action potential (GO:0086010)2.21037369
186negative regulation of protein localization to plasma membrane (GO:1903077)2.20137642
187regulation of superoxide metabolic process (GO:0090322)2.19613116
188NIK/NF-kappaB signaling (GO:0038061)2.18237757
189regulation of beta-amyloid formation (GO:1902003)2.17773970
190activation of Rac GTPase activity (GO:0032863)2.17285291
191lung lobe morphogenesis (GO:0060463)2.17083613
192regulation of establishment of protein localization to plasma membrane (GO:0090003)2.15804945
193homocysteine metabolic process (GO:0050667)2.15470713
194filopodium assembly (GO:0046847)2.15316242
195branching involved in prostate gland morphogenesis (GO:0060442)2.13907058
196regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.13236457
197JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.12697190
198positive regulation of natural killer cell differentiation (GO:0032825)2.11828969
199positive regulation of bone resorption (GO:0045780)2.10740664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.58732875
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.72194817
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43634691
4GBX2_23144817_ChIP-Seq_PC3_Human3.35372963
5GATA1_22025678_ChIP-Seq_K562_Human3.21140787
6EZH2_22144423_ChIP-Seq_EOC_Human3.12905667
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.03394412
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03085744
9* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.02934664
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.97908163
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87940789
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87880275
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87481264
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79528259
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77141795
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66227445
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.60303460
18FUS_26573619_Chip-Seq_HEK293_Human2.51958131
19TAF15_26573619_Chip-Seq_HEK293_Human2.49206004
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43141396
21MYC_22102868_ChIP-Seq_BL_Human2.36605553
22IGF1R_20145208_ChIP-Seq_DFB_Human2.35219389
23* RXR_22158963_ChIP-Seq_LIVER_Mouse2.34713136
24ZNF274_21170338_ChIP-Seq_K562_Hela2.33519943
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31805768
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24617229
27FOXO3_23340844_ChIP-Seq_DLD1_Human2.19651614
28* LXR_22158963_ChIP-Seq_LIVER_Mouse2.16780891
29SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16755254
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16123946
31EWS_26573619_Chip-Seq_HEK293_Human2.15644755
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15393879
33* P300_19829295_ChIP-Seq_ESCs_Human2.13669928
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.13613477
35VDR_22108803_ChIP-Seq_LS180_Human2.03929739
36PIAS1_25552417_ChIP-Seq_VCAP_Human2.03037093
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.99967303
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99651084
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.94068816
40RUNX_20019798_ChIP-Seq_JUKART_Human1.92664169
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.90794922
42CLOCK_20551151_ChIP-Seq_293T_Human1.87612579
43* ESR2_21235772_ChIP-Seq_MCF-7_Human1.85179822
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84880683
45* IRF8_27001747_Chip-Seq_BMDM_Mouse1.83626516
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83337031
47* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82714286
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82587108
49* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82148417
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.81345856
51* ESR1_21235772_ChIP-Seq_MCF-7_Human1.81241304
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79809383
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78354168
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78041842
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76309550
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75357085
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75327551
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74835586
59GATA6_25053715_ChIP-Seq_YYC3_Human1.74566051
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74122363
61* STAT3_23295773_ChIP-Seq_U87_Human1.73736157
62ER_23166858_ChIP-Seq_MCF-7_Human1.73667806
63VDR_21846776_ChIP-Seq_THP-1_Human1.69526411
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.68109490
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66282510
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65840168
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65730844
68* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64227871
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64125153
70* TCF4_23295773_ChIP-Seq_U87_Human1.61753893
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61542592
72GATA4_25053715_ChIP-Seq_YYC3_Human1.61435639
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61108359
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61108359
75* AR_25329375_ChIP-Seq_VCAP_Human1.60897817
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60668046
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60142451
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60035266
79TCF7_22412390_ChIP-Seq_EML_Mouse1.59754810
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.58780298
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57846226
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57056021
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57002530
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56191006
85* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56104755
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53803425
87VDR_24763502_ChIP-Seq_THP-1_Human1.53423806
88BCAT_22108803_ChIP-Seq_LS180_Human1.52950616
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.52576424
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51976986
91* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51147728
92* GATA2_21666600_ChIP-Seq_HMVEC_Human1.50970602
93AR_21572438_ChIP-Seq_LNCaP_Human1.49694522
94* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49280575
95* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49280575
96SCL_19346495_ChIP-Seq_HPC-7_Human1.49244983
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49127407
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48282294
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47651638
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47246133
101MYB_26560356_Chip-Seq_TH2_Human1.46695918
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46228487
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46178194
104CBP_20019798_ChIP-Seq_JUKART_Human1.45660787
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45660787
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45500673
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42877139
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42413562
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41710887
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.39385466
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.38631226
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.38165056
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38149054
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37445564
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37207568
116SOX2_20726797_ChIP-Seq_SW620_Human1.37098137
117RNF2_27304074_Chip-Seq_NSC_Mouse1.36970360
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.35416632
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34622499
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34509956
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33856646
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31874899
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31750870
124MAF_26560356_Chip-Seq_TH1_Human1.31411792
125* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30309255
126MYB_26560356_Chip-Seq_TH1_Human1.30170903
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29043649
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.27974705
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.27911771
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27807141
131GATA2_19941826_ChIP-Seq_K562_Human1.27653500
132SPI1_23127762_ChIP-Seq_K562_Human1.26014389
133P53_22387025_ChIP-Seq_ESCs_Mouse1.25995756
134VDR_24787735_ChIP-Seq_THP-1_Human1.25394180
135TP53_16413492_ChIP-PET_HCT116_Human1.24485353
136TCF4_22108803_ChIP-Seq_LS180_Human1.24387767
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24250021
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23260477
139* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23154898
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23090014
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21903846
142NFE2_27457419_Chip-Seq_LIVER_Mouse1.21699757
143EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21626867
144* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21605019
145* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21093062
146FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21002809
147* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20821877
148* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20567608
149* PRDM14_20953172_ChIP-Seq_ESCs_Human1.19285169
150UTX_26944678_Chip-Seq_JUKART_Human1.18715524
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18228625
152REST_21632747_ChIP-Seq_MESCs_Mouse1.17357304
153TAL1_26923725_Chip-Seq_HPCs_Mouse1.16147684
154* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15924262
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15743245
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15479703
157* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15314679
158ARNT_22903824_ChIP-Seq_MCF-7_Human1.14452650
159KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14148001
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14132205
161CMYC_18555785_Chip-Seq_ESCs_Mouse1.13476314
162SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13365308
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13161197
164NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13161197
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12928745
166IRF8_21731497_ChIP-ChIP_J774_Mouse1.12534310
167SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11943096
168KDM2B_26808549_Chip-Seq_REH_Human1.11216518
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10696559
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10609376
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10136406
172CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09361872
173EZH2_27304074_Chip-Seq_ESCs_Mouse1.08250383
174MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07614446
175SMAD_19615063_ChIP-ChIP_OVARY_Human1.07228844
176* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06656800
177JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06300644
178SMAD4_21741376_ChIP-Seq_EPCs_Human1.06194058
179CRX_20693478_ChIP-Seq_RETINA_Mouse1.06185382
180FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05097738
181GATA1_19941826_ChIP-Seq_K562_Human1.04784255
182RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03572619
183POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03187654
184P300_18555785_Chip-Seq_ESCs_Mouse1.03140943
185TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01941900
186* RACK7_27058665_Chip-Seq_MCF-7_Human0.99750109
187ELK3_25401928_ChIP-Seq_HUVEC_Human0.99119899
188* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98335167
189AR_21909140_ChIP-Seq_LNCAP_Human0.97569595
190GATA3_27048872_Chip-Seq_THYMUS_Human0.97486785
191AHR_22903824_ChIP-Seq_MCF-7_Human0.96400459
192E2F7_22180533_ChIP-Seq_HELA_Human0.95875674
193RUNX1_22412390_ChIP-Seq_EML_Mouse0.95686823
194* KDM2B_26808549_Chip-Seq_DND41_Human0.95087718
195PU_27001747_Chip-Seq_BMDM_Mouse0.94740363
196ATF3_27146783_Chip-Seq_COLON_Human0.94125249
197ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91770642
198CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91714962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.97659769
2MP0003300_gastrointestinal_ulcer4.26752698
3MP0003787_abnormal_imprinting3.07528157
4MP0008877_abnormal_DNA_methylation2.90208182
5MP0002166_altered_tumor_susceptibility2.82300747
6MP0004264_abnormal_extraembryonic_tissu2.66770553
7MP0001835_abnormal_antigen_presentation2.48413554
8MP0001873_stomach_inflammation2.46231598
9MP0000537_abnormal_urethra_morphology2.39103421
10MP0002139_abnormal_hepatobiliary_system2.38859390
11MP0000778_abnormal_nervous_system2.36840539
12MP0003880_abnormal_central_pattern2.35145234
13MP0001666_abnormal_nutrient_absorption2.26630907
14MP0005310_abnormal_salivary_gland2.21997360
15MP0000685_abnormal_immune_system2.16989651
16MP0003121_genomic_imprinting2.14362944
17MP0002006_tumorigenesis2.12903519
18MP0003122_maternal_imprinting2.05993674
19MP0006054_spinal_hemorrhage2.04284376
20MP0002254_reproductive_system_inflammat2.03684715
21MP0006276_abnormal_autonomic_nervous2.03587326
22MP0003183_abnormal_peptide_metabolism2.02985137
23MP0008057_abnormal_DNA_replication1.97492133
24MP0006292_abnormal_olfactory_placode1.95661432
25MP0010155_abnormal_intestine_physiology1.95313749
26MP0002138_abnormal_hepatobiliary_system1.94963206
27MP0010352_gastrointestinal_tract_polyps1.91482059
28MP0002638_abnormal_pupillary_reflex1.90624631
29MP0003252_abnormal_bile_duct1.90004279
30MP0005360_urolithiasis1.88961267
31MP0009046_muscle_twitch1.87257197
32MP0005365_abnormal_bile_salt1.86254741
33MP0003890_abnormal_embryonic-extraembry1.85502038
34MP0005645_abnormal_hypothalamus_physiol1.84108809
35MP0005387_immune_system_phenotype1.83594600
36MP0001790_abnormal_immune_system1.83594600
37MP0003866_abnormal_defecation1.81343065
38MP0004947_skin_inflammation1.79038808
39MP0004142_abnormal_muscle_tone1.77365527
40MP0003195_calcinosis1.77072463
41MP0002396_abnormal_hematopoietic_system1.76541543
42MP0001800_abnormal_humoral_immune1.75788792
43MP0002735_abnormal_chemical_nociception1.74554329
44MP0006072_abnormal_retinal_apoptosis1.72941742
45MP0005551_abnormal_eye_electrophysiolog1.71625032
46MP0001984_abnormal_olfaction1.67073026
47MP0000465_gastrointestinal_hemorrhage1.66209582
48MP0005646_abnormal_pituitary_gland1.65455185
49MP0001486_abnormal_startle_reflex1.65072844
50MP0004885_abnormal_endolymph1.64887048
51MP0004270_analgesia1.64343560
52MP0010678_abnormal_skin_adnexa1.64299240
53MP0002272_abnormal_nervous_system1.64035752
54MP0003045_fibrosis1.62561486
55MP0005253_abnormal_eye_physiology1.61292968
56MP0001485_abnormal_pinna_reflex1.59848403
57MP0005220_abnormal_exocrine_pancreas1.53550778
58MP0009780_abnormal_chondrocyte_physiolo1.53120942
59MP0002734_abnormal_mechanical_nocicepti1.52327446
60MP0000631_abnormal_neuroendocrine_gland1.51461470
61MP0002928_abnormal_bile_duct1.50801755
62MP0009643_abnormal_urine_homeostasis1.46179629
63MP0002736_abnormal_nociception_after1.45325933
64MP0000569_abnormal_digit_pigmentation1.44805790
65MP0003635_abnormal_synaptic_transmissio1.44628204
66MP0003453_abnormal_keratinocyte_physiol1.44426078
67MP0005085_abnormal_gallbladder_physiolo1.44247271
68MP0001968_abnormal_touch/_nociception1.43955146
69MP0002938_white_spotting1.43147527
70MP0003566_abnormal_cell_adhesion1.40904545
71MP0010386_abnormal_urinary_bladder1.38456009
72MP0002452_abnormal_antigen_presenting1.37756887
73MP0002102_abnormal_ear_morphology1.37318780
74MP0009745_abnormal_behavioral_response1.36694832
75MP0000383_abnormal_hair_follicle1.35674042
76MP0003303_peritoneal_inflammation1.34373802
77MP0000427_abnormal_hair_cycle1.33926263
78MP0003705_abnormal_hypodermis_morpholog1.33452632
79MP0003436_decreased_susceptibility_to1.32276299
80MP0003868_abnormal_feces_composition1.31337516
81MP0004924_abnormal_behavior1.30996963
82MP0005386_behavior/neurological_phenoty1.30996963
83MP0004808_abnormal_hematopoietic_stem1.30856991
84MP0004134_abnormal_chest_morphology1.30579118
85MP0005025_abnormal_response_to1.30505469
86MP0004133_heterotaxia1.29690669
87MP0008875_abnormal_xenobiotic_pharmacok1.28396709
88MP0002009_preneoplasia1.28382331
89MP0002837_dystrophic_cardiac_calcinosis1.28381411
90MP0002572_abnormal_emotion/affect_behav1.25138801
91MP0003937_abnormal_limbs/digits/tail_de1.25119318
92MP0002067_abnormal_sensory_capabilities1.25030422
93MP0002063_abnormal_learning/memory/cond1.24157350
94MP0001845_abnormal_inflammatory_respons1.23766894
95MP0002557_abnormal_social/conspecific_i1.23749080
96MP0004043_abnormal_pH_regulation1.23424112
97MP0002184_abnormal_innervation1.23005657
98MP0001529_abnormal_vocalization1.22620225
99MP0002136_abnormal_kidney_physiology1.21618622
100MP0000858_altered_metastatic_potential1.21000695
101MP0008995_early_reproductive_senescence1.20334190
102MP0000604_amyloidosis1.19845306
103MP0001765_abnormal_ion_homeostasis1.19363818
104MP0004145_abnormal_muscle_electrophysio1.18903610
105MP0001853_heart_inflammation1.17790461
106MP0010329_abnormal_lipoprotein_level1.15865918
107MP0002723_abnormal_immune_serum1.15480780
108MP0000955_abnormal_spinal_cord1.15458004
109MP0005000_abnormal_immune_tolerance1.14952759
110MP0002233_abnormal_nose_morphology1.14608098
111MP0004742_abnormal_vestibular_system1.13724214
112MP0002064_seizures1.13421499
113MP0000609_abnormal_liver_physiology1.13105663
114MP0005423_abnormal_somatic_nervous1.12992050
115MP0003283_abnormal_digestive_organ1.12741741
116MP0005083_abnormal_biliary_tract1.12187886
117MP0002733_abnormal_thermal_nociception1.11750534
118MP0002420_abnormal_adaptive_immunity1.11680446
119MP0001819_abnormal_immune_cell1.10852506
120MP0000477_abnormal_intestine_morphology1.10238705
121MP0005174_abnormal_tail_pigmentation1.08966608
122MP0005023_abnormal_wound_healing1.08705035
123MP0009785_altered_susceptibility_to1.07725746
124MP0002234_abnormal_pharynx_morphology1.07168506
125MP0003136_yellow_coat_color1.05922269
126MP0001663_abnormal_digestive_system1.05861935
127MP0001970_abnormal_pain_threshold1.04840888
128MP0002419_abnormal_innate_immunity1.04536918
129MP0002882_abnormal_neuron_morphology1.03913392
130MP0005076_abnormal_cell_differentiation1.03571405
131MP0005671_abnormal_response_to1.03392564
132MP0005503_abnormal_tendon_morphology1.03373730
133MP0002398_abnormal_bone_marrow1.03263924
134MP0002822_catalepsy1.02664148
135MP0008789_abnormal_olfactory_epithelium1.02152058
136MP0000538_abnormal_urinary_bladder1.00869023
137MP0004215_abnormal_myocardial_fiber1.00784189
138MP0003191_abnormal_cellular_cholesterol1.00368544
139MP0002751_abnormal_autonomic_nervous1.00235475
140MP0009764_decreased_sensitivity_to1.00152719
141MP0000490_abnormal_crypts_of1.00146864
142MP0001299_abnormal_eye_distance/0.98385651
143MP0002752_abnormal_somatic_nervous0.98073661
144MP0000716_abnormal_immune_system0.97933732
145MP0000013_abnormal_adipose_tissue0.97645389
146MP0001216_abnormal_epidermal_layer0.96722768
147MP0005187_abnormal_penis_morphology0.96449735
148MP0004859_abnormal_synaptic_plasticity0.94457140
149MP0005171_absent_coat_pigmentation0.93948645
150MP0005332_abnormal_amino_acid0.92212645
151MP0005195_abnormal_posterior_eye0.92150653
152MP0000689_abnormal_spleen_morphology0.92093098
153MP0005464_abnormal_platelet_physiology0.91481884
154MP0005394_taste/olfaction_phenotype0.90234223
155MP0005499_abnormal_olfactory_system0.90234223
156MP0002095_abnormal_skin_pigmentation0.89961032
157MP0002060_abnormal_skin_morphology0.89540692
158MP0003091_abnormal_cell_migration0.89144508
159MP0002909_abnormal_adrenal_gland0.89075213
160MP0004147_increased_porphyrin_level0.88870082
161MP0000372_irregular_coat_pigmentation0.88836709
162MP0001756_abnormal_urination0.88353976
163MP0000462_abnormal_digestive_system0.88196996
164MP0005391_vision/eye_phenotype0.87976750
165MP0001881_abnormal_mammary_gland0.87967731
166MP0003656_abnormal_erythrocyte_physiolo0.87955577
167MP0001501_abnormal_sleep_pattern0.87780756
168MP0002152_abnormal_brain_morphology0.87518150
169MP0002876_abnormal_thyroid_physiology0.87277190
170MP0003385_abnormal_body_wall0.86815164
171MP0001188_hyperpigmentation0.86760977
172MP0003755_abnormal_palate_morphology0.86729633
173MP0003763_abnormal_thymus_physiology0.86560526
174MP0005367_renal/urinary_system_phenotyp0.85933488
175MP0000516_abnormal_urinary_system0.85933488
176MP0001177_atelectasis0.85873610
177MP0005381_digestive/alimentary_phenotyp0.85634764
178MP0002148_abnormal_hypersensitivity_rea0.85597748
179MP0002796_impaired_skin_barrier0.85094071
180MP0001986_abnormal_taste_sensitivity0.84808461
181MP0009278_abnormal_bone_marrow0.84149906
182MP0008469_abnormal_protein_level0.83997310
183MP0005166_decreased_susceptibility_to0.82868438
184MP0001849_ear_inflammation0.82811026
185MP0009384_cardiac_valve_regurgitation0.81659021
186MP0002722_abnormal_immune_system0.81172113
187MP0003935_abnormal_craniofacial_develop0.80118913
188MP0001944_abnormal_pancreas_morphology0.79930710
189MP0004085_abnormal_heartbeat0.79406344
190MP0003633_abnormal_nervous_system0.78321570
191MP0002160_abnormal_reproductive_system0.78286483
192MP0002429_abnormal_blood_cell0.78155142
193MP0000049_abnormal_middle_ear0.77583879
194MP0002109_abnormal_limb_morphology0.76948482
195MP0009763_increased_sensitivity_to0.76686839
196MP0000627_abnormal_mammary_gland0.75284011
197MP0001191_abnormal_skin_condition0.74155639
198MP0003172_abnormal_lysosome_physiology0.74128380

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.42755976
2Colitis (HP:0002583)3.98777224
3Interstitial pulmonary disease (HP:0006530)3.90524636
4Agammaglobulinemia (HP:0004432)3.88277119
5Chronic hepatic failure (HP:0100626)3.62777212
6Nephronophthisis (HP:0000090)3.62269112
7Inflammation of the large intestine (HP:0002037)3.61058564
8Pancreatic fibrosis (HP:0100732)3.57393147
9Molar tooth sign on MRI (HP:0002419)3.54547376
10Abnormality of midbrain morphology (HP:0002418)3.54547376
11Gastrointestinal inflammation (HP:0004386)3.43013091
12Pancreatic cysts (HP:0001737)3.40493508
13True hermaphroditism (HP:0010459)3.38989038
14Micronodular cirrhosis (HP:0001413)3.32601163
15Abnormality of the renal medulla (HP:0100957)3.29525922
16Volvulus (HP:0002580)3.22508475
17Abnormality of the fingertips (HP:0001211)3.17491827
18Cellulitis (HP:0100658)3.17265566
19Medial flaring of the eyebrow (HP:0010747)3.09892184
20Pustule (HP:0200039)3.03520378
21Aortic aneurysm (HP:0004942)3.02978350
22Papilloma (HP:0012740)2.97230270
23Verrucae (HP:0200043)2.97230270
24Abnormality of the renal cortex (HP:0011035)2.88355022
25Recurrent viral infections (HP:0004429)2.88016863
26Drooling (HP:0002307)2.87072747
27Broad-based gait (HP:0002136)2.86776313
28Onycholysis (HP:0001806)2.84216785
29Febrile seizures (HP:0002373)2.77439098
30Genital tract atresia (HP:0001827)2.77285683
31Gait imbalance (HP:0002141)2.71879617
32Gastrointestinal stroma tumor (HP:0100723)2.70617996
33Esophageal varix (HP:0002040)2.70213500
34Periodontitis (HP:0000704)2.68514300
35Intestinal atresia (HP:0011100)2.63571232
36Vaginal atresia (HP:0000148)2.59815972
37Abnormality of the gastric mucosa (HP:0004295)2.57748534
38Subacute progressive viral hepatitis (HP:0006572)2.57315594
39Focal segmental glomerulosclerosis (HP:0000097)2.56810004
40Recurrent fungal infections (HP:0002841)2.56574618
41Congenital primary aphakia (HP:0007707)2.55983547
42Excessive salivation (HP:0003781)2.54397432
43Focal seizures (HP:0007359)2.52588086
44Abnormality of the ischium (HP:0003174)2.51315284
45Abnormality of B cell number (HP:0010975)2.50895570
46B lymphocytopenia (HP:0010976)2.50895570
47Gout (HP:0001997)2.49384456
48IgM deficiency (HP:0002850)2.49315380
49Recurrent bronchitis (HP:0002837)2.48928031
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.48050410
51Osteomyelitis (HP:0002754)2.47090542
52Milia (HP:0001056)2.46929486
53Nephrogenic diabetes insipidus (HP:0009806)2.43358693
54Glomerulosclerosis (HP:0000096)2.42124805
55Gaze-evoked nystagmus (HP:0000640)2.40964173
56Abdominal distention (HP:0003270)2.38825412
57Atonic seizures (HP:0010819)2.37277968
58Focal motor seizures (HP:0011153)2.37243889
59Hypoplastic ischia (HP:0003175)2.36699502
60Absent speech (HP:0001344)2.36296392
61Tubulointerstitial nephritis (HP:0001970)2.34903215
62Tubular atrophy (HP:0000092)2.34431754
63Right ventricular cardiomyopathy (HP:0011663)2.32939339
64Hematochezia (HP:0002573)2.31884421
65Urinary glycosaminoglycan excretion (HP:0003541)2.31468055
66Mucopolysacchariduria (HP:0008155)2.31468055
67Progressive cerebellar ataxia (HP:0002073)2.31460894
68Viral hepatitis (HP:0006562)2.29492111
69Widely spaced teeth (HP:0000687)2.28183747
70IgA deficiency (HP:0002720)2.27581466
71Renal cortical cysts (HP:0000803)2.26262776
72Papillary thyroid carcinoma (HP:0002895)2.23986611
73Dialeptic seizures (HP:0011146)2.23696042
74Rectal prolapse (HP:0002035)2.23306756
75Hemiparesis (HP:0001269)2.22088403
76Poor coordination (HP:0002370)2.20542537
77Cystic liver disease (HP:0006706)2.20513186
78Arterial tortuosity (HP:0005116)2.20052586
79Macroorchidism (HP:0000053)2.19535450
80Recurrent sinusitis (HP:0011108)2.18634079
81Protruding tongue (HP:0010808)2.18529138
82Dehydration (HP:0001944)2.16885504
83Ureteral stenosis (HP:0000071)2.16120417
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14632662
85Abnormality of polysaccharide metabolism (HP:0011012)2.14632662
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14632662
87Deep venous thrombosis (HP:0002625)2.14217459
88Congenital hepatic fibrosis (HP:0002612)2.13905019
89Abnormal foot bone ossification (HP:0010675)2.13590732
90Chronic diarrhea (HP:0002028)2.12448438
91Postaxial foot polydactyly (HP:0001830)2.11298912
92Aqueductal stenosis (HP:0002410)2.11222707
93Chronic otitis media (HP:0000389)2.10807894
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.10282262
95Ureteral obstruction (HP:0006000)2.09394570
96Genetic anticipation (HP:0003743)2.08471691
97Fair hair (HP:0002286)2.07046956
98Narrow forehead (HP:0000341)2.06401590
99Thoracolumbar scoliosis (HP:0002944)2.06159779
100Meningitis (HP:0001287)2.05252366
101Postaxial hand polydactyly (HP:0001162)2.05065679
102Abnormality of chloride homeostasis (HP:0011422)2.04964757
103Lymphopenia (HP:0001888)2.04190432
104Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03970755
105Cupped ear (HP:0000378)2.02140872
106Cerebral aneurysm (HP:0004944)2.02033927
107Tubulointerstitial abnormality (HP:0001969)2.01808110
108Eczematoid dermatitis (HP:0000976)2.01791474
109Midline defect of the nose (HP:0004122)2.00044320
110Cutaneous finger syndactyly (HP:0010554)1.99192623
111Abnormality of the labia minora (HP:0012880)1.98810964
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.98623994
113Thrombocytosis (HP:0001894)1.98140863
114Abnormality of the common coagulation pathway (HP:0010990)1.97582629
115Hypoplastic iliac wings (HP:0002866)1.96956635
116Cerebellar dysplasia (HP:0007033)1.96214189
117Hypothermia (HP:0002045)1.95998542
118Bowing of the arm (HP:0006488)1.95932591
119Bowed forearm bones (HP:0003956)1.95932591
120Abnormality of cells of the lymphoid lineage (HP:0012140)1.93525392
121Abnormal drinking behavior (HP:0030082)1.93402078
122Polydipsia (HP:0001959)1.93402078
123Absence seizures (HP:0002121)1.92876054
124Restrictive lung disease (HP:0002091)1.92244925
125Truncal obesity (HP:0001956)1.91971160
126Pachygyria (HP:0001302)1.91728123
127Emphysema (HP:0002097)1.91500943
128Absent/shortened dynein arms (HP:0200106)1.90917940
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.90917940
130Hydroxyprolinuria (HP:0003080)1.90901097
131Abnormality of proline metabolism (HP:0010907)1.90901097
132Optic nerve hypoplasia (HP:0000609)1.90120631
133Bifid tongue (HP:0010297)1.89302112
134Anencephaly (HP:0002323)1.87568749
135Sepsis (HP:0100806)1.87494251
136Mitral stenosis (HP:0001718)1.87201715
137Pili torti (HP:0003777)1.86912144
138Abnormality of the pubic bones (HP:0003172)1.86873358
139Chronic mucocutaneous candidiasis (HP:0002728)1.86367641
140Recurrent cutaneous fungal infections (HP:0011370)1.86367641
141Oligodactyly (hands) (HP:0001180)1.86184816
142Hypoplasia of the thymus (HP:0000778)1.86002401
143Thyroiditis (HP:0100646)1.85677930
144Short foot (HP:0001773)1.85612845
145Gastrointestinal atresia (HP:0002589)1.85111262
146Atrophic scars (HP:0001075)1.85052711
147Hip dysplasia (HP:0001385)1.84283847
148Vacuolated lymphocytes (HP:0001922)1.84201541
149Abnormal ciliary motility (HP:0012262)1.84017476
150Preaxial foot polydactyly (HP:0001841)1.84010044
151Congenital stationary night blindness (HP:0007642)1.83754870
152Ulnar bowing (HP:0003031)1.83454583
153Vascular tortuosity (HP:0004948)1.83249609
154Abnormal respiratory motile cilium morphology (HP:0005938)1.83184110
155Abnormal respiratory epithelium morphology (HP:0012253)1.83184110
156Hepatitis (HP:0012115)1.82525258
157Villous atrophy (HP:0011473)1.81415912
158Abnormality of small intestinal villus morphology (HP:0011472)1.81415912
159Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81398246
160Short 4th metacarpal (HP:0010044)1.81398246
161Exotropia (HP:0000577)1.81317061
162Tented upper lip vermilion (HP:0010804)1.81131518
163Panhypogammaglobulinemia (HP:0003139)1.80205210
164Aneurysm (HP:0002617)1.80181710
165Type II lissencephaly (HP:0007260)1.79971382
166Abnormality of purine metabolism (HP:0004352)1.79152337
167Lissencephaly (HP:0001339)1.78918245
168Radial bowing (HP:0002986)1.78362702
169Cheilitis (HP:0100825)1.77291041
170Dysostosis multiplex (HP:0000943)1.76014670
171Ankyloglossia (HP:0010296)1.75957281
172Plantar hyperkeratosis (HP:0007556)1.75869600
173Abolished electroretinogram (ERG) (HP:0000550)1.75859569
174Myocardial infarction (HP:0001658)1.75688941
175Large for gestational age (HP:0001520)1.74662153
176Glioma (HP:0009733)1.73027462
177Renal hypoplasia (HP:0000089)1.72932039
178Complement deficiency (HP:0004431)1.72898771
179Abnormal platelet function (HP:0011869)1.72463357
180Impaired platelet aggregation (HP:0003540)1.72463357
181Specific learning disability (HP:0001328)1.71834371
182Male pseudohermaphroditism (HP:0000037)1.71824522
183Recurrent bacterial skin infections (HP:0005406)1.71650443
184Short tibia (HP:0005736)1.71461086
185Biliary tract neoplasm (HP:0100574)1.71417148
186Prominent nasal bridge (HP:0000426)1.70724882
187Vasculitis (HP:0002633)1.70579943
188Spondylolisthesis (HP:0003302)1.70568438
189Hyperactive renin-angiotensin system (HP:0000841)1.70534036
190Cone-rod dystrophy (HP:0000548)1.70102119
191Pheochromocytoma (HP:0002666)1.70032918
192Gingival bleeding (HP:0000225)1.69668414
193Astrocytoma (HP:0009592)1.69531426
194Abnormality of the astrocytes (HP:0100707)1.69531426
195Acute lymphatic leukemia (HP:0006721)1.68872365
196Hypoplastic labia majora (HP:0000059)1.68872019
197Abnormality of chromosome stability (HP:0003220)1.66622555
198Limb dystonia (HP:0002451)1.66339266
199Colon cancer (HP:0003003)1.66311424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.19641102
2STK394.31223827
3ERN14.00112482
4OXSR13.53795721
5WNK33.42754990
6MST43.31550741
7CASK3.31260836
8FRK2.89616880
9PNCK2.79698167
10BMPR1B2.60447456
11TNIK2.51681362
12MARK12.39576219
13TAOK32.38768538
14EEF2K2.32910926
15MAP3K42.25804160
16MAP3K102.24340454
17MAPK132.14210458
18PTK62.11973750
19MAP4K11.91440911
20STK101.90010650
21LATS11.87060534
22LMTK21.85938205
23MKNK21.85726456
24ACVR1B1.84517262
25SIK11.80044512
26TRIB31.77796306
27FGFR41.75177557
28LRRK21.70704236
29PINK11.68649869
30MAP4K21.68364429
31RPS6KB21.68284893
32EPHB11.62796810
33NTRK31.61857975
34RIPK11.60321468
35AKT31.60085739
36MAP3K141.47034730
37PKN21.44493357
38JAK11.43994904
39TGFBR21.43488740
40TYK21.42689942
41SCYL21.37252251
42MKNK11.33268975
43ERBB31.30015465
44ADRBK21.26028158
45STK38L1.21988227
46TRIM281.20446877
47BTK1.18623420
48PAK31.15019049
49MST1R1.14651675
50GRK11.13275227
51MAP3K71.12470521
52CSF1R1.12390469
53PLK21.12102976
54FER1.12094515
55BCR1.11874271
56CAMK1G1.10717844
57MAP2K71.10206102
58EPHA41.08690824
59ZAK1.05684944
60PTK21.03842912
61BRD41.03726299
62CDK61.01253991
63GRK61.00542129
64CAMK1D1.00501717
65NEK90.97115121
66TNK20.96563115
67PRKCE0.96554963
68OBSCN0.96437183
69NTRK20.95426940
70JAK30.95306637
71NLK0.93322041
72CSNK1G20.91531000
73EIF2AK30.90512587
74SGK4940.89615977
75SGK2230.89615977
76CSNK1G10.87420054
77TBK10.85856726
78FGFR30.85509040
79PAK40.85299494
80MAP2K20.85166311
81DYRK1B0.84824956
82DYRK20.84613771
83PLK40.83980687
84MAP3K130.83918102
85SGK30.83520905
86CHUK0.83119276
87CSK0.81862551
88TGFBR10.79109068
89RIPK40.77608322
90ITK0.77165543
91CDK30.76564358
92NUAK10.76436444
93MAP3K20.75393476
94MUSK0.74744323
95CCNB10.72322050
96PRKCG0.72005940
97JAK20.71934433
98INSRR0.70215501
99CDK120.70091237
100WNK40.69985952
101SYK0.68964679
102STK30.68577628
103PKN10.68567569
104CSNK1A1L0.65756618
105SIK20.65312508
106WNK10.63362318
107IKBKE0.62590996
108PIK3CA0.61787402
109FLT30.61411761
110ZAP700.60327853
111PRKG10.58563519
112PRKCI0.57419821
113ADRBK10.57148049
114PTK2B0.56836303
115TRPM70.56753126
116CSNK1G30.56022595
117TTN0.56014063
118SGK10.55621014
119CDK90.55042359
120TEC0.53840655
121HIPK20.53454911
122MAP2K40.52867028
123PIK3CG0.51412758
124STK110.50147541
125DYRK1A0.50141662
126CAMK2A0.50066695
127EGFR0.49486909
128MELK0.49252431
129MINK10.49232948
130MAPK150.48949192
131CSNK1D0.48149991
132MAP2K30.48133501
133ATM0.47962870
134PRKACB0.47627644
135KIT0.47624954
136TIE10.47370142
137MATK0.46689988
138SGK20.46625607
139MAP2K10.45957792
140PRKACA0.45937390
141TLK10.45917400
142PRKCQ0.44956930
143CAMK10.44856749
144MAPK110.44391973
145HCK0.43841681
146NEK20.43815879
147FGFR20.43058284
148PHKG20.42375545
149PHKG10.42375545
150DAPK20.42048086
151CDK50.41843819
152MTOR0.40868751
153CDK40.40784825
154MAP3K80.40610772
155PRKCH0.38794898
156WEE10.38495204
157VRK10.38462604
158LCK0.38025540
159ABL10.38007115
160DMPK0.37727894
161UHMK10.37327411
162EPHA30.37239474
163CSNK1E0.36894352
164MAPKAPK30.36785207
165PRKAA10.36311051
166BCKDK0.36156078
167LYN0.35909495
168BMX0.35189370
169FGFR10.34938916
170ERBB20.33080235
171PDGFRA0.31601018
172SRC0.31527753
173RPS6KA40.31055174
174CAMKK10.30066592
175PDGFRB0.29662493
176MAP3K30.28753670

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98261535
2Nitrogen metabolism_Homo sapiens_hsa009102.53893849
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28062501
4Phototransduction_Homo sapiens_hsa047442.21111872
5B cell receptor signaling pathway_Homo sapiens_hsa046622.11520428
6Butanoate metabolism_Homo sapiens_hsa006501.97095862
7Dorso-ventral axis formation_Homo sapiens_hsa043201.92298767
8Glutamatergic synapse_Homo sapiens_hsa047241.89807155
9Circadian entrainment_Homo sapiens_hsa047131.88882912
10Primary immunodeficiency_Homo sapiens_hsa053401.87923423
11Hematopoietic cell lineage_Homo sapiens_hsa046401.87551302
12Non-homologous end-joining_Homo sapiens_hsa034501.79733187
13Small cell lung cancer_Homo sapiens_hsa052221.79661231
14Taste transduction_Homo sapiens_hsa047421.78494925
15Fanconi anemia pathway_Homo sapiens_hsa034601.76884963
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74682719
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74444777
18Insulin secretion_Homo sapiens_hsa049111.71023439
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66437574
20Linoleic acid metabolism_Homo sapiens_hsa005911.64147168
21Protein export_Homo sapiens_hsa030601.62140307
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.58954381
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57628124
24Morphine addiction_Homo sapiens_hsa050321.55569362
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55178422
26Long-term depression_Homo sapiens_hsa047301.54536720
27GABAergic synapse_Homo sapiens_hsa047271.53729540
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52923960
29Propanoate metabolism_Homo sapiens_hsa006401.52609546
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51943133
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50585043
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49255296
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46208096
34Serotonergic synapse_Homo sapiens_hsa047261.43479344
35Circadian rhythm_Homo sapiens_hsa047101.42588315
36Dopaminergic synapse_Homo sapiens_hsa047281.42494123
37Lysine degradation_Homo sapiens_hsa003101.41322611
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.41197481
39Cocaine addiction_Homo sapiens_hsa050301.40956230
40Caffeine metabolism_Homo sapiens_hsa002321.38291692
41Olfactory transduction_Homo sapiens_hsa047401.36761356
42Ether lipid metabolism_Homo sapiens_hsa005651.36452526
43Chronic myeloid leukemia_Homo sapiens_hsa052201.36271946
44Renin-angiotensin system_Homo sapiens_hsa046141.35355973
45Osteoclast differentiation_Homo sapiens_hsa043801.33884811
46Sulfur metabolism_Homo sapiens_hsa009201.31857268
47Amphetamine addiction_Homo sapiens_hsa050311.31689662
48Pancreatic cancer_Homo sapiens_hsa052121.31292873
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.30849226
50Renin secretion_Homo sapiens_hsa049241.30169267
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28775813
52Adherens junction_Homo sapiens_hsa045201.28671437
53Toxoplasmosis_Homo sapiens_hsa051451.27207850
54Salivary secretion_Homo sapiens_hsa049701.26066449
55Pancreatic secretion_Homo sapiens_hsa049721.25390152
56Leishmaniasis_Homo sapiens_hsa051401.22986948
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.21246763
58Arginine biosynthesis_Homo sapiens_hsa002201.18910361
59ABC transporters_Homo sapiens_hsa020101.17554963
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15241932
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.13465442
62Cholinergic synapse_Homo sapiens_hsa047251.13364000
63Hepatitis C_Homo sapiens_hsa051601.09395782
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.09381388
65Hedgehog signaling pathway_Homo sapiens_hsa043401.07506423
66Axon guidance_Homo sapiens_hsa043601.05904353
67Basal transcription factors_Homo sapiens_hsa030221.05577944
68cAMP signaling pathway_Homo sapiens_hsa040241.03036360
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01945513
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01637927
71Thyroid hormone synthesis_Homo sapiens_hsa049181.00955795
72Proteoglycans in cancer_Homo sapiens_hsa052051.00950178
73Calcium signaling pathway_Homo sapiens_hsa040200.99502959
74Bile secretion_Homo sapiens_hsa049760.98795045
75Insulin resistance_Homo sapiens_hsa049310.97907287
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95989966
77Non-small cell lung cancer_Homo sapiens_hsa052230.95284466
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95179769
79Ovarian steroidogenesis_Homo sapiens_hsa049130.95168220
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94821137
81Fatty acid degradation_Homo sapiens_hsa000710.94706569
82Steroid biosynthesis_Homo sapiens_hsa001000.94629876
83Bladder cancer_Homo sapiens_hsa052190.94289262
84Oxytocin signaling pathway_Homo sapiens_hsa049210.92509059
85Antigen processing and presentation_Homo sapiens_hsa046120.92492110
86Protein digestion and absorption_Homo sapiens_hsa049740.92303646
87Homologous recombination_Homo sapiens_hsa034400.91907865
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91851648
89TNF signaling pathway_Homo sapiens_hsa046680.91849767
90Regulation of autophagy_Homo sapiens_hsa041400.91102963
91Focal adhesion_Homo sapiens_hsa045100.89892268
92Complement and coagulation cascades_Homo sapiens_hsa046100.88744099
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87676383
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86872988
95Other glycan degradation_Homo sapiens_hsa005110.86497190
96Tryptophan metabolism_Homo sapiens_hsa003800.85636493
97N-Glycan biosynthesis_Homo sapiens_hsa005100.85576130
98RNA degradation_Homo sapiens_hsa030180.85213620
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83908848
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83714561
101Influenza A_Homo sapiens_hsa051640.83311041
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82675833
103ECM-receptor interaction_Homo sapiens_hsa045120.82565794
104Inositol phosphate metabolism_Homo sapiens_hsa005620.82525677
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82497704
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81511799
107Endometrial cancer_Homo sapiens_hsa052130.80849582
108Apoptosis_Homo sapiens_hsa042100.80733071
109Pentose phosphate pathway_Homo sapiens_hsa000300.80110194
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79882716
111Prostate cancer_Homo sapiens_hsa052150.79577476
112Hepatitis B_Homo sapiens_hsa051610.79233019
113Peroxisome_Homo sapiens_hsa041460.79094446
114TGF-beta signaling pathway_Homo sapiens_hsa043500.78341845
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.78308935
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77697914
117Fat digestion and absorption_Homo sapiens_hsa049750.75770698
118Pertussis_Homo sapiens_hsa051330.75688732
119Gap junction_Homo sapiens_hsa045400.75437784
120Gastric acid secretion_Homo sapiens_hsa049710.75377225
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74828955
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.74575603
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74513807
124Platelet activation_Homo sapiens_hsa046110.74311446
125Measles_Homo sapiens_hsa051620.74102914
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73798069
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71994061
128Tuberculosis_Homo sapiens_hsa051520.71679714
129Amoebiasis_Homo sapiens_hsa051460.71330072
130Basal cell carcinoma_Homo sapiens_hsa052170.70959626
131Acute myeloid leukemia_Homo sapiens_hsa052210.70944619
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70561057
133Cardiac muscle contraction_Homo sapiens_hsa042600.70242487
134Staphylococcus aureus infection_Homo sapiens_hsa051500.69889961
135Selenocompound metabolism_Homo sapiens_hsa004500.69856489
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69828755
137Retinol metabolism_Homo sapiens_hsa008300.69373966
138PPAR signaling pathway_Homo sapiens_hsa033200.68084702
139Vitamin digestion and absorption_Homo sapiens_hsa049770.67990034
140Starch and sucrose metabolism_Homo sapiens_hsa005000.67504662
141Thyroid cancer_Homo sapiens_hsa052160.67084274
142MicroRNAs in cancer_Homo sapiens_hsa052060.66287267
143Glycerolipid metabolism_Homo sapiens_hsa005610.64558580
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63815694
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63530711
146Melanoma_Homo sapiens_hsa052180.62817479
147Chemical carcinogenesis_Homo sapiens_hsa052040.62752522
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62688322
149Alcoholism_Homo sapiens_hsa050340.61886633
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61148533
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60662861
152Shigellosis_Homo sapiens_hsa051310.60166432
153FoxO signaling pathway_Homo sapiens_hsa040680.59206354
154Long-term potentiation_Homo sapiens_hsa047200.59170237
155Ras signaling pathway_Homo sapiens_hsa040140.58948348
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56891113
157Glioma_Homo sapiens_hsa052140.56844752
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.55990114
159Type II diabetes mellitus_Homo sapiens_hsa049300.55953580
160Fatty acid biosynthesis_Homo sapiens_hsa000610.55527954
161Hippo signaling pathway_Homo sapiens_hsa043900.55274904
162Dilated cardiomyopathy_Homo sapiens_hsa054140.53346349
163Chemokine signaling pathway_Homo sapiens_hsa040620.53000943
164Tight junction_Homo sapiens_hsa045300.52152775
165Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51260384
166Adipocytokine signaling pathway_Homo sapiens_hsa049200.49533066
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48871852
168Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47593391
169Viral carcinogenesis_Homo sapiens_hsa052030.46973373
170Fatty acid metabolism_Homo sapiens_hsa012120.46259111
171beta-Alanine metabolism_Homo sapiens_hsa004100.46182358
172Lysosome_Homo sapiens_hsa041420.46108124
173Histidine metabolism_Homo sapiens_hsa003400.45653809
174Viral myocarditis_Homo sapiens_hsa054160.45625293
175Prolactin signaling pathway_Homo sapiens_hsa049170.45552980
176Malaria_Homo sapiens_hsa051440.45150213
177Legionellosis_Homo sapiens_hsa051340.44667764
178Wnt signaling pathway_Homo sapiens_hsa043100.43714047
179Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43200553

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