CHDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.12412941
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.12412941
3L-phenylalanine metabolic process (GO:0006558)6.82059085
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.82059085
5aromatic amino acid family catabolic process (GO:0009074)6.53435300
6indole-containing compound catabolic process (GO:0042436)5.99976623
7indolalkylamine catabolic process (GO:0046218)5.99976623
8tryptophan catabolic process (GO:0006569)5.99976623
9glyoxylate metabolic process (GO:0046487)5.88744518
10kynurenine metabolic process (GO:0070189)5.73376043
11cysteine metabolic process (GO:0006534)5.73208680
12very-low-density lipoprotein particle assembly (GO:0034379)5.67517119
13tryptophan metabolic process (GO:0006568)5.67100647
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51622368
15lysine catabolic process (GO:0006554)5.51547800
16lysine metabolic process (GO:0006553)5.51547800
17bile acid biosynthetic process (GO:0006699)5.46552398
18alpha-linolenic acid metabolic process (GO:0036109)5.45738179
19urea metabolic process (GO:0019627)5.28945952
20urea cycle (GO:0000050)5.28945952
21sulfur amino acid catabolic process (GO:0000098)5.28212351
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.26108517
23homocysteine metabolic process (GO:0050667)5.06428457
24intestinal cholesterol absorption (GO:0030299)5.05429015
25serine family amino acid catabolic process (GO:0009071)5.03742577
26epoxygenase P450 pathway (GO:0019373)5.03671631
27nitrogen cycle metabolic process (GO:0071941)4.87047910
28complement activation, alternative pathway (GO:0006957)4.74012546
29aromatic amino acid family metabolic process (GO:0009072)4.73574441
30high-density lipoprotein particle remodeling (GO:0034375)4.72635954
31bile acid metabolic process (GO:0008206)4.71183831
32* amino-acid betaine metabolic process (GO:0006577)4.66210096
33negative regulation of fibrinolysis (GO:0051918)4.65411169
34peptidyl-glutamic acid carboxylation (GO:0017187)4.64993964
35protein carboxylation (GO:0018214)4.64993964
36low-density lipoprotein particle remodeling (GO:0034374)4.61205310
37regulation of protein activation cascade (GO:2000257)4.61127408
38drug catabolic process (GO:0042737)4.60972484
39drug transmembrane transport (GO:0006855)4.58917137
40alpha-amino acid catabolic process (GO:1901606)4.55580536
41regulation of triglyceride catabolic process (GO:0010896)4.52091435
42plasma lipoprotein particle organization (GO:0071827)4.50357121
43urate metabolic process (GO:0046415)4.49434498
44protein-lipid complex assembly (GO:0065005)4.48470004
45regulation of fibrinolysis (GO:0051917)4.44032371
46cellular ketone body metabolic process (GO:0046950)4.42426624
47blood coagulation, intrinsic pathway (GO:0007597)4.41187744
48tyrosine metabolic process (GO:0006570)4.36462942
49regulation of complement activation (GO:0030449)4.33101108
50intestinal absorption (GO:0050892)4.32218351
51cellular amino acid catabolic process (GO:0009063)4.28080407
52serine family amino acid metabolic process (GO:0009069)4.25981636
53glutamate metabolic process (GO:0006536)4.25111358
54indolalkylamine metabolic process (GO:0006586)4.24528967
55cellular modified amino acid catabolic process (GO:0042219)4.24151912
56acylglycerol homeostasis (GO:0055090)4.22837931
57triglyceride homeostasis (GO:0070328)4.22837931
58negative regulation of sterol transport (GO:0032372)4.21374183
59negative regulation of cholesterol transport (GO:0032375)4.21374183
60plasma lipoprotein particle remodeling (GO:0034369)4.18325402
61protein-lipid complex remodeling (GO:0034368)4.18325402
62macromolecular complex remodeling (GO:0034367)4.18325402
63reverse cholesterol transport (GO:0043691)4.18310603
64regulation of cholesterol esterification (GO:0010872)4.18220798
65protein-lipid complex subunit organization (GO:0071825)4.16354505
66short-chain fatty acid metabolic process (GO:0046459)4.15757805
67bile acid and bile salt transport (GO:0015721)4.10968670
68amine catabolic process (GO:0009310)4.10743296
69cellular biogenic amine catabolic process (GO:0042402)4.10743296
70cellular glucuronidation (GO:0052695)4.07752266
71glycine metabolic process (GO:0006544)4.06586673
72ethanol oxidation (GO:0006069)4.04634211
73benzene-containing compound metabolic process (GO:0042537)4.03378051
74phospholipid efflux (GO:0033700)4.02375861
75serine family amino acid biosynthetic process (GO:0009070)4.00323377
76coenzyme catabolic process (GO:0009109)3.99276754
77acetyl-CoA metabolic process (GO:0006084)3.98942492
78exogenous drug catabolic process (GO:0042738)3.96926148
79aspartate family amino acid catabolic process (GO:0009068)3.92080923
80dicarboxylic acid biosynthetic process (GO:0043650)3.90347169
81fatty acid beta-oxidation (GO:0006635)3.88588174
82plasma lipoprotein particle clearance (GO:0034381)3.87139716
83drug transport (GO:0015893)3.86645913
84carboxylic acid catabolic process (GO:0046395)3.84322010
85organic acid catabolic process (GO:0016054)3.84322010
86imidazole-containing compound metabolic process (GO:0052803)3.83910376
87fatty acid oxidation (GO:0019395)3.83406543
882-oxoglutarate metabolic process (GO:0006103)3.82658741
89regulation of cholesterol homeostasis (GO:2000188)3.81578746
90ketone body metabolic process (GO:1902224)3.81160087
91carnitine metabolic process (GO:0009437)3.79420607
92regulation of bile acid biosynthetic process (GO:0070857)3.77033274
93lipid oxidation (GO:0034440)3.75775695
94valine metabolic process (GO:0006573)3.71312855
95negative regulation of protein activation cascade (GO:2000258)3.69675927
96monocarboxylic acid catabolic process (GO:0072329)3.68619649
97cholesterol efflux (GO:0033344)3.68375968
98uronic acid metabolic process (GO:0006063)3.68186489
99glucuronate metabolic process (GO:0019585)3.68186489
100proline metabolic process (GO:0006560)3.67697404
101fatty acid catabolic process (GO:0009062)3.66433849
102negative regulation of lipase activity (GO:0060192)3.64241417
103phospholipid homeostasis (GO:0055091)3.64184292
104plasma lipoprotein particle assembly (GO:0034377)3.60750436
105omega-hydroxylase P450 pathway (GO:0097267)3.60525368
106aldehyde catabolic process (GO:0046185)3.60292754
107cholesterol homeostasis (GO:0042632)3.59853562
108arginine metabolic process (GO:0006525)3.59644158
109flavonoid metabolic process (GO:0009812)3.59256661
110sterol homeostasis (GO:0055092)3.57062990
111positive regulation of lipid catabolic process (GO:0050996)3.56472086
112drug metabolic process (GO:0017144)3.56294203
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55767937
114regulation of plasminogen activation (GO:0010755)3.54556690
115positive regulation of lipoprotein lipase activity (GO:0051006)3.52162958
116embryonic retina morphogenesis in camera-type eye (GO:0060059)3.50542553
117lipoprotein metabolic process (GO:0042157)3.39189114
118ethanol metabolic process (GO:0006067)3.35393815
119heme transport (GO:0015886)3.29581962
120protein activation cascade (GO:0072376)3.28727972
121acute-phase response (GO:0006953)3.25170560
122complement activation, classical pathway (GO:0006958)3.23836934
123phenylpropanoid metabolic process (GO:0009698)3.19966454
124diacylglycerol metabolic process (GO:0046339)3.19795851
125positive regulation of triglyceride lipase activity (GO:0061365)3.18318921
126cholesterol transport (GO:0030301)3.18019082
127sterol transport (GO:0015918)3.18019082
128regulation of apoptotic cell clearance (GO:2000425)3.17483611
129C4-dicarboxylate transport (GO:0015740)3.14901622
130L-ascorbic acid metabolic process (GO:0019852)3.14296974
131nephron epithelium morphogenesis (GO:0072088)3.07641732
132nephron tubule morphogenesis (GO:0072078)3.07641732
133negative regulation of complement activation (GO:0045916)3.06146590
134lipid homeostasis (GO:0055088)3.04466807
135fibrinolysis (GO:0042730)2.99717825
136negative regulation of blood coagulation (GO:0030195)2.99044578
137negative regulation of hemostasis (GO:1900047)2.99044578
138oxidative demethylation (GO:0070989)2.97307806
139transepithelial transport (GO:0070633)2.97177125
140positive regulation of steroid metabolic process (GO:0045940)2.95974144
141positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.92617302
142regulation of humoral immune response (GO:0002920)2.89323504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.02050072
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.96339189
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28423948
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.27722431
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.36575259
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.83456066
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.49851575
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89138957
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.62029292
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32859909
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21161962
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07739502
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1822334
14CLOCK_20551151_ChIP-Seq_293T_Human1.88629562
15GATA1_22025678_ChIP-Seq_K562_Human1.84887233
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81665051
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68257505
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.67775626
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57337542
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51725209
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49934912
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48405667
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46690958
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38070194
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35514657
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31425673
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26524909
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.25946106
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23570374
30GATA4_25053715_ChIP-Seq_YYC3_Human1.22321079
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21041632
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16210871
33HTT_18923047_ChIP-ChIP_STHdh_Human1.15954095
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15946838
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.13480129
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.11852316
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10787314
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.09344487
39GBX2_23144817_ChIP-Seq_PC3_Human1.08694302
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07636015
41RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07059528
42ZNF274_21170338_ChIP-Seq_K562_Hela1.04356625
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03513765
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.00930619
45DROSHA_22980978_ChIP-Seq_HELA_Human1.00293061
46ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99667879
47MYC_19829295_ChIP-Seq_ESCs_Human0.99106702
48ERA_21632823_ChIP-Seq_H3396_Human0.98765519
49RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97821746
50HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97281923
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97130984
52BCAT_22108803_ChIP-Seq_LS180_Human0.96780515
53REST_21632747_ChIP-Seq_MESCs_Mouse0.95337393
54AR_21572438_ChIP-Seq_LNCaP_Human0.92746643
55NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92119883
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91949388
57IRF8_22096565_ChIP-ChIP_GC-B_Human0.91263136
58NFE2_27457419_Chip-Seq_LIVER_Mouse0.91230787
59ER_23166858_ChIP-Seq_MCF-7_Human0.90686640
60VDR_22108803_ChIP-Seq_LS180_Human0.90428983
61HOXB7_26014856_ChIP-Seq_BT474_Human0.89049787
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88319587
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88314706
64OCT4_20526341_ChIP-Seq_ESCs_Human0.87607624
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86178792
66ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85793532
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85631008
68TCF4_22108803_ChIP-Seq_LS180_Human0.85277430
69FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84775741
70FOXA1_25329375_ChIP-Seq_VCAP_Human0.84775741
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84523316
72RAC3_21632823_ChIP-Seq_H3396_Human0.84252594
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83895488
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83589562
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83112819
76FOXH1_21741376_ChIP-Seq_ESCs_Human0.82837493
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82823816
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82523153
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81815651
80STAT3_23295773_ChIP-Seq_U87_Human0.81571865
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.81400980
82GATA6_25053715_ChIP-Seq_YYC3_Human0.80838642
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79463497
84SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78879933
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78543938
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.78123191
87ZNF263_19887448_ChIP-Seq_K562_Human0.77482675
88* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76882249
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.76565382
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76348268
91ESRRB_18555785_Chip-Seq_ESCs_Mouse0.75841873
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75231548
93TCF4_23295773_ChIP-Seq_U87_Human0.75153649
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74559415
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74486175
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.74125976
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74037536
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.73600599
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.73170743
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73113600
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72953777
102NCOR_22424771_ChIP-Seq_293T_Human0.72858829
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69477699
104CEBPB_22108803_ChIP-Seq_LS180_Human0.68719641
105EGR1_19032775_ChIP-ChIP_M12_Human0.68664360
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.68571536
107* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67448034
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67445677
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67093947
110LXR_22292898_ChIP-Seq_THP-1_Human0.65937694
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64300658
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.62495450
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62373080
114GATA2_19941826_ChIP-Seq_K562_Human0.61435301
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.59935252
116AR_20517297_ChIP-Seq_VCAP_Human0.59632265
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59413477
118SOX2_20726797_ChIP-Seq_SW620_Human0.58661937
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57931857
120STAT1_17558387_ChIP-Seq_HELA_Human0.56338672
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55838420
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55838420
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55245574
124* RARB_24833708_ChIP-Seq_LIVER_Mouse0.54631103
125MYC_19915707_ChIP-ChIP_AK7_Human0.53777580
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53396144
127RACK7_27058665_Chip-Seq_MCF-7_Human0.52999085
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.52811537
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52741274
130CBP_21632823_ChIP-Seq_H3396_Human0.52062959
131GATA1_19941826_ChIP-Seq_K562_Human0.51879243
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.51065701
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.50464774
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.50123679
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.49783792
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48650617
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47776210
138CDX2_22108803_ChIP-Seq_LS180_Human0.47765034
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.46935213
140P53_21459846_ChIP-Seq_SAOS-2_Human0.46731770
141TAF2_19829295_ChIP-Seq_ESCs_Human0.46066610
142AR_21909140_ChIP-Seq_LNCAP_Human0.46002614
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45074414
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.44475847
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.44475847
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.43622998
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43460263
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.42907572
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.42867298
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.42279471
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.42155983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.97823621
2MP0002139_abnormal_hepatobiliary_system7.83609197
3MP0005085_abnormal_gallbladder_physiolo5.84712810
4MP0005365_abnormal_bile_salt5.78461660
5MP0008875_abnormal_xenobiotic_pharmacok4.88277643
6MP0003252_abnormal_bile_duct3.94205481
7MP0003806_abnormal_nucleotide_metabolis3.58731816
8MP0010329_abnormal_lipoprotein_level3.33898695
9MP0005332_abnormal_amino_acid3.14900530
10MP0003195_calcinosis2.86317504
11MP0001666_abnormal_nutrient_absorption2.85759241
12MP0009840_abnormal_foam_cell2.79420821
13MP0004019_abnormal_vitamin_homeostasis2.70206478
14MP0005083_abnormal_biliary_tract2.54613113
15MP0002138_abnormal_hepatobiliary_system2.33481577
16MP0003122_maternal_imprinting2.28030636
17MP0003191_abnormal_cellular_cholesterol2.24305509
18MP0000609_abnormal_liver_physiology2.06485725
19MP0002118_abnormal_lipid_homeostasis2.05167510
20MP0009780_abnormal_chondrocyte_physiolo1.98126521
21MP0000566_synostosis1.87960483
22MP0005319_abnormal_enzyme/_coenzyme1.84083111
23MP0009643_abnormal_urine_homeostasis1.81731757
24MP0003868_abnormal_feces_composition1.70723828
25MP0005584_abnormal_enzyme/coenzyme_acti1.63981489
26MP0001764_abnormal_homeostasis1.61407996
27MP0002909_abnormal_adrenal_gland1.59294854
28MP0004885_abnormal_endolymph1.56213485
29MP0003123_paternal_imprinting1.49191356
30MP0005451_abnormal_body_composition1.48731032
31MP0005636_abnormal_mineral_homeostasis1.36784454
32MP0003879_abnormal_hair_cell1.33489142
33MP0004043_abnormal_pH_regulation1.31705057
34MP0005670_abnormal_white_adipose1.29640271
35MP0003186_abnormal_redox_activity1.29516082
36MP0005379_endocrine/exocrine_gland_phen1.27593244
37MP0002254_reproductive_system_inflammat1.26348312
38MP0005551_abnormal_eye_electrophysiolog1.25662171
39MP0003183_abnormal_peptide_metabolism1.18510869
40MP0002089_abnormal_postnatal_growth/wei1.14102218
41MP0001756_abnormal_urination1.13536660
42MP0003705_abnormal_hypodermis_morpholog1.12999923
43MP0002876_abnormal_thyroid_physiology1.12310453
44MP0000598_abnormal_liver_morphology1.12067445
45MP0005646_abnormal_pituitary_gland1.11010055
46MP0005645_abnormal_hypothalamus_physiol1.09795767
47MP0009697_abnormal_copulation1.05999013
48MP0001944_abnormal_pancreas_morphology1.05073264
49MP0009764_decreased_sensitivity_to1.01228576
50MP0005084_abnormal_gallbladder_morpholo1.01145861
51MP0003656_abnormal_erythrocyte_physiolo1.00153074
52MP0003283_abnormal_digestive_organ0.98116831
53MP0005647_abnormal_sex_gland0.97772476
54MP0004270_analgesia0.97152053
55MP0003011_delayed_dark_adaptation0.95801432
56MP0002136_abnormal_kidney_physiology0.94772230
57MP0000604_amyloidosis0.94460370
58MP0004742_abnormal_vestibular_system0.93616122
59MP0009642_abnormal_blood_homeostasis0.89819017
60MP0001765_abnormal_ion_homeostasis0.89651063
61MP0009763_increased_sensitivity_to0.89421242
62MP0002971_abnormal_brown_adipose0.88375752
63MP0002132_abnormal_respiratory_system0.87624303
64MP0008469_abnormal_protein_level0.87591593
65MP0003172_abnormal_lysosome_physiology0.86585177
66MP0002693_abnormal_pancreas_physiology0.83877089
67MP0001485_abnormal_pinna_reflex0.83849586
68MP0010234_abnormal_vibrissa_follicle0.83116105
69MP0004264_abnormal_extraembryonic_tissu0.82403757
70MP0005220_abnormal_exocrine_pancreas0.81829595
71MP0001661_extended_life_span0.80828638
72MP0005666_abnormal_adipose_tissue0.80509961
73MP0002078_abnormal_glucose_homeostasis0.79787312
74* MP0006036_abnormal_mitochondrial_physio0.79508934
75MP0005535_abnormal_body_temperature0.79326983
76MP0005408_hypopigmentation0.78194802
77MP0004130_abnormal_muscle_cell0.77883341
78MP0009765_abnormal_xenobiotic_induced0.73976922
79MP0005334_abnormal_fat_pad0.72158501
80MP0005167_abnormal_blood-brain_barrier0.71895695
81MP0002938_white_spotting0.71615164
82MP0002928_abnormal_bile_duct0.71017580
83MP0003300_gastrointestinal_ulcer0.70941013
84MP0002557_abnormal_social/conspecific_i0.70823582
85MP0005376_homeostasis/metabolism_phenot0.69659647
86MP0002796_impaired_skin_barrier0.67690088
87MP0002160_abnormal_reproductive_system0.62978047
88MP0003890_abnormal_embryonic-extraembry0.61236576
89MP0005410_abnormal_fertilization0.60915834
90MP0002163_abnormal_gland_morphology0.60656171
91MP0010368_abnormal_lymphatic_system0.60352673
92MP0002064_seizures0.59498374
93MP0001501_abnormal_sleep_pattern0.59423180
94MP0003121_genomic_imprinting0.59362926
95MP0003329_amyloid_beta_deposits0.58499198
96MP0005448_abnormal_energy_balance0.57694816
97MP0004133_heterotaxia0.56511673
98MP0000678_abnormal_parathyroid_gland0.56215777
99MP0001984_abnormal_olfaction0.55554966
100MP0003638_abnormal_response/metabolism_0.55376859
101MP0001270_distended_abdomen0.54971927
102MP0000631_abnormal_neuroendocrine_gland0.54722367
103MP0005266_abnormal_metabolism0.54459342
104MP0009046_muscle_twitch0.53229768
105MP0005058_abnormal_lysosome_morphology0.52640000
106MP0003724_increased_susceptibility_to0.52525247
107MP0001986_abnormal_taste_sensitivity0.52096666
108MP0002166_altered_tumor_susceptibility0.51935166
109MP0005395_other_phenotype0.51284080
110MP0002229_neurodegeneration0.51229325
111MP0006292_abnormal_olfactory_placode0.51077091
112MP0005452_abnormal_adipose_tissue0.50862252
113MP0003690_abnormal_glial_cell0.50541705
114MP0009053_abnormal_anal_canal0.50063898
115MP0000538_abnormal_urinary_bladder0.49657463
116MP0002069_abnormal_eating/drinking_beha0.49353935
117MP0009115_abnormal_fat_cell0.49326246
118MP0003787_abnormal_imprinting0.48252930
119MP0003953_abnormal_hormone_level0.48186812
120MP0000230_abnormal_systemic_arterial0.47815723
121MP0001664_abnormal_digestion0.46167869
122MP0009745_abnormal_behavioral_response0.45632571
123MP0005187_abnormal_penis_morphology0.44773836
124MP0003633_abnormal_nervous_system0.44742944
125MP0002168_other_aberrant_phenotype0.44681848
126MP0005464_abnormal_platelet_physiology0.44429818
127MP0002098_abnormal_vibrissa_morphology0.43517488
128MP0008961_abnormal_basal_metabolism0.42966920
129MP0002970_abnormal_white_adipose0.40360140
130MP0008873_increased_physiological_sensi0.39879089
131MP0008872_abnormal_physiological_respon0.39691938
132MP0004782_abnormal_surfactant_physiolog0.39588022
133MP0002135_abnormal_kidney_morphology0.39160901
134MP0001881_abnormal_mammary_gland0.38901919
135MP0005166_decreased_susceptibility_to0.38544943
136MP0008874_decreased_physiological_sensi0.38169458
137MP0003718_maternal_effect0.38065995
138MP0003075_altered_response_to0.37749556
139MP0001845_abnormal_inflammatory_respons0.36894596
140MP0000639_abnormal_adrenal_gland0.36573960
141MP0009672_abnormal_birth_weight0.36064405
142MP0003436_decreased_susceptibility_to0.35852263
143MP0009384_cardiac_valve_regurgitation0.35758483
144MP0000579_abnormal_nail_morphology0.35142431
145MP0005375_adipose_tissue_phenotype0.34349630
146MP0002060_abnormal_skin_morphology0.33962120
147MP0004381_abnormal_hair_follicle0.33234721
148MP0003959_abnormal_lean_body0.30762294
149MP0004185_abnormal_adipocyte_glucose0.30026791

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.52105187
2Intrahepatic cholestasis (HP:0001406)6.46408315
3Deep venous thrombosis (HP:0002625)6.22339845
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.90965614
5Xanthomatosis (HP:0000991)5.68371023
6Hypobetalipoproteinemia (HP:0003563)5.50268984
7Prolonged partial thromboplastin time (HP:0003645)5.26743320
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.99128297
9Hyperglycinuria (HP:0003108)4.88886879
10Hyperammonemia (HP:0001987)4.65292181
11Complement deficiency (HP:0004431)4.55881660
12Abnormality of serine family amino acid metabolism (HP:0010894)4.54599247
13Abnormality of glycine metabolism (HP:0010895)4.54599247
14Hyperlipoproteinemia (HP:0010980)4.54481798
15Ketosis (HP:0001946)4.50687702
16Hyperglycinemia (HP:0002154)4.43892312
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21980312
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.16319163
19Hypolipoproteinemia (HP:0010981)4.13714153
20Joint hemorrhage (HP:0005261)4.05095212
21Epidermoid cyst (HP:0200040)4.00727486
22Fat malabsorption (HP:0002630)3.86899910
23Abnormality of fatty-acid metabolism (HP:0004359)3.82443556
24Hypoglycemic coma (HP:0001325)3.80601122
25Abnormality of the common coagulation pathway (HP:0010990)3.79798725
26Gout (HP:0001997)3.79676566
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.77240533
28Conjugated hyperbilirubinemia (HP:0002908)3.59391837
29Abnormality of methionine metabolism (HP:0010901)3.57847414
30Hypoalphalipoproteinemia (HP:0003233)3.57785899
31Ketoacidosis (HP:0001993)3.56843428
32Abnormality of purine metabolism (HP:0004352)3.53698569
33Abnormality of nucleobase metabolism (HP:0010932)3.48798018
34Abnormality of pyrimidine metabolism (HP:0004353)3.38996917
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33017178
36Delayed CNS myelination (HP:0002188)3.31778395
37Abnormality of complement system (HP:0005339)3.26079067
38Hypercholesterolemia (HP:0003124)3.18336327
39Abnormality of the intrinsic pathway (HP:0010989)3.16004893
40Hyperbilirubinemia (HP:0002904)3.05778293
41Metabolic acidosis (HP:0001942)3.01939124
42Abnormality of serum amino acid levels (HP:0003112)2.97904683
43Dicarboxylic aciduria (HP:0003215)2.95740827
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95740827
45Abnormality of the nasal septum (HP:0000419)2.93166162
46Proximal tubulopathy (HP:0000114)2.87388187
47Vascular calcification (HP:0004934)2.84022610
48Generalized aminoaciduria (HP:0002909)2.82284890
49Alkalosis (HP:0001948)2.80506759
50Hepatocellular carcinoma (HP:0001402)2.78799046
51Steatorrhea (HP:0002570)2.76663713
52Malnutrition (HP:0004395)2.75877210
53Increased purine levels (HP:0004368)2.74704932
54Hyperuricemia (HP:0002149)2.74704932
55Lethargy (HP:0001254)2.72257648
56Abnormality of proline metabolism (HP:0010907)2.68574619
57Hydroxyprolinuria (HP:0003080)2.68574619
58Metabolic alkalosis (HP:0200114)2.67168340
59Potter facies (HP:0002009)2.62681286
60Facial shape deformation (HP:0011334)2.62681286
61Pigmentary retinal degeneration (HP:0001146)2.59603259
62Myocardial infarction (HP:0001658)2.58874316
63Cardiovascular calcification (HP:0011915)2.51183972
64Pancreatic islet-cell hyperplasia (HP:0004510)2.49734054
65Hyperinsulinemic hypoglycemia (HP:0000825)2.45201230
66Spastic diplegia (HP:0001264)2.44983398
67Acanthocytosis (HP:0001927)2.44203779
68Irritability (HP:0000737)2.40138832
69Glycosuria (HP:0003076)2.37791729
70Abnormality of urine glucose concentration (HP:0011016)2.37791729
71Pancreatitis (HP:0001733)2.37024829
72Spontaneous abortion (HP:0005268)2.36680763
73Arthropathy (HP:0003040)2.35050424
74Systemic lupus erythematosus (HP:0002725)2.34960920
75Skin nodule (HP:0200036)2.34628842
76Vomiting (HP:0002013)2.33076916
77Enlarged kidneys (HP:0000105)2.29473863
78Neonatal onset (HP:0003623)2.29198488
79Hypothermia (HP:0002045)2.28847427
80Abnormality of the renal cortex (HP:0011035)2.28369606
81Sensorimotor neuropathy (HP:0007141)2.27967220
82Abnormal tarsal ossification (HP:0008369)2.26675229
83Late onset (HP:0003584)2.26045772
84Rectal prolapse (HP:0002035)2.25753148
85Hypochromic microcytic anemia (HP:0004840)2.24696614
86Hypophosphatemic rickets (HP:0004912)2.23843721
87Cerebral edema (HP:0002181)2.22132329
88Hypoglycemic seizures (HP:0002173)2.20682915
89Rickets (HP:0002748)2.18789036
90Broad alveolar ridges (HP:0000187)2.18374902
91Abnormality of the vitreous humor (HP:0004327)2.15410256
92Esophageal varix (HP:0002040)2.15048674
93Abnormality of endocrine pancreas physiology (HP:0012093)2.12045767
94Abnormality of the pancreatic islet cells (HP:0006476)2.12045767
95Abnormality of chloride homeostasis (HP:0011422)2.11270093
96Abnormal enzyme/coenzyme activity (HP:0012379)2.09635167
97Abnormal urine output (HP:0012590)2.09218120
98Abnormality of renal excretion (HP:0011036)2.08314330
99Hypomagnesemia (HP:0002917)2.07739263
100Nephritis (HP:0000123)2.04834295
101Abnormal gallbladder morphology (HP:0012437)2.04632919
102Glomerulonephritis (HP:0000099)2.03413303
103Cholelithiasis (HP:0001081)2.02042119
104Widely patent fontanelles and sutures (HP:0004492)2.01990527
105Nephrolithiasis (HP:0000787)1.99951022
106Hyperactive renin-angiotensin system (HP:0000841)1.98089924
107Hypokalemic alkalosis (HP:0001949)1.97270451
108Cholecystitis (HP:0001082)1.97209132
109Abnormal gallbladder physiology (HP:0012438)1.97209132
110Thrombophlebitis (HP:0004418)1.96919847
111Abnormality of vitamin B metabolism (HP:0004340)1.96670999
112Mitral stenosis (HP:0001718)1.95988750
113Brushfield spots (HP:0001088)1.93833721
114Hyperglycemia (HP:0003074)1.93596737
115Increased circulating renin level (HP:0000848)1.92305178
116Hemorrhage of the eye (HP:0011885)1.92101723
117Renal cortical cysts (HP:0000803)1.92042562
118Hyperphosphaturia (HP:0003109)1.91138658
119Abnormal cartilage morphology (HP:0002763)1.90266360
120Amyloidosis (HP:0011034)1.89497117
121Abnormality of alkaline phosphatase activity (HP:0004379)1.85918236
122Recurrent gram-negative bacterial infections (HP:0005420)1.85778090
123Abnormality of vitamin metabolism (HP:0100508)1.85447588
124Opisthotonus (HP:0002179)1.85189321
125Megaloblastic anemia (HP:0001889)1.84521182
126Hepatoblastoma (HP:0002884)1.83831173
127Menorrhagia (HP:0000132)1.83262423
128Abnormality of magnesium homeostasis (HP:0004921)1.82282465
129Nausea (HP:0002018)1.82056307
130Confusion (HP:0001289)1.80364385
131Bifid scrotum (HP:0000048)1.79833071
132Increased serum pyruvate (HP:0003542)1.79481989
133Status epilepticus (HP:0002133)1.75514996
134Abnormality of glycolysis (HP:0004366)1.73794586
135Glomerulosclerosis (HP:0000096)1.73763157
136Bronchomalacia (HP:0002780)1.72649259
137Abnormal urine phosphate concentration (HP:0012599)1.71885466
138Abnormality of potassium homeostasis (HP:0011042)1.70382891
139Hyperaldosteronism (HP:0000859)1.70100734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45851360
2FGFR43.87820328
3ERN13.83959862
4SIK13.74389999
5TAOK33.14141472
6MST1R2.82531701
7WNK42.71142821
8WNK32.60537470
9INSRR2.52337097
10FRK2.34357183
11ACVR1B2.34313619
12AKT32.30992349
13OXSR12.19706033
14ERBB42.11838658
15TRIB32.09556746
16PKN21.98959093
17NUAK11.89161035
18MAPKAPK31.77908681
19LATS11.77363612
20PTK61.72634697
21MAPK111.72340525
22CASK1.68044926
23GRK11.63742019
24FLT31.58445747
25MAP2K41.53932302
26MST41.52023601
27STK38L1.48640578
28FGFR11.47517565
29NTRK31.45650000
30NLK1.45619200
31PIK3CG1.42751595
32PDK41.42712242
33PDK31.42712242
34GRK61.41855287
35EPHB11.36328592
36TYK21.34882989
37MAP3K71.34753351
38FGFR21.32153000
39PRKAA21.30846372
40PHKG11.29900847
41PHKG21.29900847
42WNK11.22854831
43ADRBK21.19673912
44MAP3K91.16561943
45FER1.15605734
46RIPK11.14904959
47JAK21.13359663
48CAMK1D1.10746340
49NEK91.06261244
50MAP3K101.05025241
51ABL21.02075442
52BMPR1B0.99412079
53STK390.93322103
54MAP2K30.93179345
55CSNK1G10.91905375
56MAP3K30.91179932
57SGK30.91115340
58JAK10.88813644
59MET0.88218584
60PAK30.87680611
61DAPK20.86704176
62KDR0.82121667
63SGK10.81395520
64PRKCI0.81081820
65PRKAA10.81041324
66ERBB20.80939114
67MAPK40.80854813
68ICK0.79997175
69ZAK0.78344983
70PINK10.78341386
71IRAK30.77627613
72GSK3A0.77049631
73FGFR30.75965782
74PDK20.74811975
75CSNK1E0.74810757
76MAP4K20.73750276
77TBK10.73529421
78EPHA40.73395708
79PRKCZ0.71691876
80SGK4940.71414851
81SGK2230.71414851
82CDK60.71395895
83MAP3K140.71146759
84MAPK150.70858583
85PDPK10.68115526
86PTK20.67632716
87SIK20.67584965
88CDK30.66738123
89PRKCG0.65285748
90TNIK0.64625435
91SGK20.63926453
92CAMK1G0.63398191
93CSK0.62346720
94PRKACG0.61846775
95EPHA30.60313975
96MAP2K60.60283740
97CSNK1A10.60219528
98NME10.58054901
99DYRK1B0.56998813
100LRRK20.56858427
101CHUK0.56782539
102CDK120.55943772
103RPS6KB10.55284283
104PNCK0.52256478
105MAP2K20.49558959
106PDK10.49414816
107EIF2AK10.49357237
108TYRO30.49328863
109MAP3K60.47837804
110TIE10.47184431
111STK100.46023629
112TGFBR20.45286630
113MAPK120.44980362
114RPS6KB20.43535783
115AKT20.43486635
116STK30.43007789
117MAP3K20.42662750
118CAMK2D0.41912145
119TNK20.41274428
120PRKCQ0.41228142
121MAPKAPK50.40202750
122MTOR0.38855046
123MAP2K10.38219150
124MAP3K110.38073949
125CDK40.37883961
126STK380.37883677
127RET0.37199072
128CDC42BPA0.35628827
129IRAK10.35380501
130PRKD30.34919985
131PRKACA0.33884542
132CAMK2G0.33695046
133IGF1R0.33452545
134LMTK20.33374371
135CSNK1D0.32874589
136MYLK0.32669166
137PRKCE0.32505392
138RPS6KA30.32374851
139NEK10.31901888
140ZAP700.30684335
141ITK0.30486886
142PRKG10.30124281
143PRKG20.29341748
144MAPK140.28785627
145EPHA20.28721484
146EEF2K0.27273819
147IKBKE0.26879634
148MAP3K50.26562049
149MAP4K10.25559083
150PIK3CA0.25515273
151ABL10.25257373
152MAP3K130.25178411

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96917543
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41822583
3Nitrogen metabolism_Homo sapiens_hsa009103.31712857
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99081953
5Arginine biosynthesis_Homo sapiens_hsa002202.83015684
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76135570
7Tryptophan metabolism_Homo sapiens_hsa003802.73238670
8Fatty acid degradation_Homo sapiens_hsa000712.69503845
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66489122
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52550593
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38071748
12Butanoate metabolism_Homo sapiens_hsa006502.37045487
13* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31500553
14Propanoate metabolism_Homo sapiens_hsa006402.31411662
15Complement and coagulation cascades_Homo sapiens_hsa046102.25343002
16Peroxisome_Homo sapiens_hsa041462.19565059
17PPAR signaling pathway_Homo sapiens_hsa033201.99075400
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98838448
19Fatty acid metabolism_Homo sapiens_hsa012121.96833376
20Histidine metabolism_Homo sapiens_hsa003401.94270659
21beta-Alanine metabolism_Homo sapiens_hsa004101.87213015
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86267901
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74963869
24Chemical carcinogenesis_Homo sapiens_hsa052041.74007823
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73148133
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70421245
27Caffeine metabolism_Homo sapiens_hsa002321.68631083
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68075071
29Pyruvate metabolism_Homo sapiens_hsa006201.66193044
30Bile secretion_Homo sapiens_hsa049761.61328871
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.59610519
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58103638
33Selenocompound metabolism_Homo sapiens_hsa004501.51547156
34Retinol metabolism_Homo sapiens_hsa008301.51499425
35Sulfur metabolism_Homo sapiens_hsa009201.49447195
36Phenylalanine metabolism_Homo sapiens_hsa003601.41695982
37Starch and sucrose metabolism_Homo sapiens_hsa005001.41591557
38Staphylococcus aureus infection_Homo sapiens_hsa051501.41347726
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.40622024
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38597645
41Fat digestion and absorption_Homo sapiens_hsa049751.34697845
42Carbon metabolism_Homo sapiens_hsa012001.30556996
43Fatty acid elongation_Homo sapiens_hsa000621.27009998
44Tyrosine metabolism_Homo sapiens_hsa003501.27005622
45Vitamin digestion and absorption_Homo sapiens_hsa049771.26372922
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.22451862
47Folate biosynthesis_Homo sapiens_hsa007901.19339999
48Biosynthesis of amino acids_Homo sapiens_hsa012301.18957408
49ABC transporters_Homo sapiens_hsa020101.17883679
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12984094
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12511924
52Arginine and proline metabolism_Homo sapiens_hsa003301.02504035
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.99961436
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99925578
55Lysine degradation_Homo sapiens_hsa003100.99388191
56Steroid biosynthesis_Homo sapiens_hsa001000.95580459
57Glycerolipid metabolism_Homo sapiens_hsa005610.90954309
58Glutathione metabolism_Homo sapiens_hsa004800.86449733
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83064650
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81275506
61Sulfur relay system_Homo sapiens_hsa041220.80599352
62Vitamin B6 metabolism_Homo sapiens_hsa007500.80172080
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79758172
64Pentose phosphate pathway_Homo sapiens_hsa000300.68204315
65Ether lipid metabolism_Homo sapiens_hsa005650.65690023
66Fatty acid biosynthesis_Homo sapiens_hsa000610.62625231
67One carbon pool by folate_Homo sapiens_hsa006700.57332106
68Sphingolipid metabolism_Homo sapiens_hsa006000.53590054
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49449383
70Insulin secretion_Homo sapiens_hsa049110.49108398
71* Metabolic pathways_Homo sapiens_hsa011000.47400434
72Fructose and mannose metabolism_Homo sapiens_hsa000510.38483347
73Galactose metabolism_Homo sapiens_hsa000520.38017285
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31483710
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29724927
76Pancreatic secretion_Homo sapiens_hsa049720.28828516
77Insulin resistance_Homo sapiens_hsa049310.28273806
78N-Glycan biosynthesis_Homo sapiens_hsa005100.28048215
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.27537054
80Renin-angiotensin system_Homo sapiens_hsa046140.23617668
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22916530
82Phototransduction_Homo sapiens_hsa047440.18754431
83Linoleic acid metabolism_Homo sapiens_hsa005910.17909277
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.17040222
85Mineral absorption_Homo sapiens_hsa049780.13015611
86Glucagon signaling pathway_Homo sapiens_hsa049220.11765813
87Protein digestion and absorption_Homo sapiens_hsa049740.09794225
88Prion diseases_Homo sapiens_hsa050200.09262719
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08884163
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08780638
91AMPK signaling pathway_Homo sapiens_hsa041520.08654983
92Thyroid hormone synthesis_Homo sapiens_hsa049180.06553573
93Circadian rhythm_Homo sapiens_hsa047100.05828549
94Inositol phosphate metabolism_Homo sapiens_hsa005620.04498468
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.01986180
96Tight junction_Homo sapiens_hsa045300.01959120
97Serotonergic synapse_Homo sapiens_hsa047260.01573006
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.00133579
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2048644
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2007817
101Regulation of autophagy_Homo sapiens_hsa04140-0.1991307
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1909440
103Lysosome_Homo sapiens_hsa04142-0.1740060
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1483787
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1459845
106Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1387327
107Hepatitis C_Homo sapiens_hsa05160-0.1331527
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1096779
109Insulin signaling pathway_Homo sapiens_hsa04910-0.0889020
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0708938
111Other glycan degradation_Homo sapiens_hsa00511-0.0699800
112Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0630830
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0622257

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