CHEK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.79626130
2ribosome assembly (GO:0042255)4.61596964
3DNA replication checkpoint (GO:0000076)4.43637543
4rRNA modification (GO:0000154)4.25923768
5proteasome assembly (GO:0043248)4.06479644
6telomere maintenance via semi-conservative replication (GO:0032201)4.04066740
7protein localization to kinetochore (GO:0034501)4.03070173
8tRNA methylation (GO:0030488)4.02331688
9purine nucleobase biosynthetic process (GO:0009113)3.96712020
10DNA-dependent DNA replication (GO:0006261)3.91075905
11* regulation of nuclear cell cycle DNA replication (GO:0033262)3.89418203
12mitotic metaphase plate congression (GO:0007080)3.89409815
13kinetochore assembly (GO:0051382)3.85633112
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.81800610
15regulation of mitotic spindle checkpoint (GO:1903504)3.81800610
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.80733064
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80733064
18DNA synthesis involved in DNA repair (GO:0000731)3.79487699
19ribosome biogenesis (GO:0042254)3.77923991
20telomere maintenance via recombination (GO:0000722)3.76169177
21DNA strand elongation involved in DNA replication (GO:0006271)3.75286470
22regulation of double-strand break repair via homologous recombination (GO:0010569)3.74846811
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.68223771
24termination of RNA polymerase III transcription (GO:0006386)3.68223771
25regulation of spindle organization (GO:0090224)3.67056972
26nucleobase biosynthetic process (GO:0046112)3.66833601
27DNA strand elongation (GO:0022616)3.65108224
28kinetochore organization (GO:0051383)3.61254095
29DNA replication initiation (GO:0006270)3.61188912
30CENP-A containing nucleosome assembly (GO:0034080)3.58398274
31termination of RNA polymerase I transcription (GO:0006363)3.54411711
32chromatin remodeling at centromere (GO:0031055)3.51988522
33rRNA methylation (GO:0031167)3.51682633
34establishment of integrated proviral latency (GO:0075713)3.51466385
35regulation of centriole replication (GO:0046599)3.51446773
36mitotic recombination (GO:0006312)3.46849532
37transcription from RNA polymerase I promoter (GO:0006360)3.44801247
38telomere maintenance via telomere lengthening (GO:0010833)3.44594027
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.44478889
40sister chromatid segregation (GO:0000819)3.44050699
417-methylguanosine mRNA capping (GO:0006370)3.43731422
42DNA ligation (GO:0006266)3.41183170
43transcription-coupled nucleotide-excision repair (GO:0006283)3.41031300
44DNA replication-dependent nucleosome assembly (GO:0006335)3.39407452
45DNA replication-dependent nucleosome organization (GO:0034723)3.39407452
46protein localization to chromosome, centromeric region (GO:0071459)3.38751263
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37226092
48pseudouridine synthesis (GO:0001522)3.36672952
497-methylguanosine RNA capping (GO:0009452)3.36413652
50RNA capping (GO:0036260)3.36413652
51RNA methylation (GO:0001510)3.36149188
52maturation of 5.8S rRNA (GO:0000460)3.34394796
53regulation of mitotic spindle organization (GO:0060236)3.34131854
54protein K6-linked ubiquitination (GO:0085020)3.32933245
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31461672
56DNA catabolic process, exonucleolytic (GO:0000738)3.30499843
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28633953
58DNA damage response, detection of DNA damage (GO:0042769)3.26647864
59synapsis (GO:0007129)3.25993278
60metaphase plate congression (GO:0051310)3.23955200
61spindle checkpoint (GO:0031577)3.23754476
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.22503842
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22503842
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22503842
65negative regulation of sister chromatid segregation (GO:0033046)3.22503842
66spindle assembly checkpoint (GO:0071173)3.20331585
67negative regulation of chromosome segregation (GO:0051985)3.18080467
68DNA strand renaturation (GO:0000733)3.16878111
69regulation of mitochondrial translation (GO:0070129)3.16814846
70mitotic spindle assembly checkpoint (GO:0007094)3.16195868
71mitochondrial DNA replication (GO:0006264)3.14876570
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.14838263
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13588100
74respiratory chain complex IV assembly (GO:0008535)3.13567443
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13347437
76DNA double-strand break processing (GO:0000729)3.12718073
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11708296
78recombinational repair (GO:0000725)3.11474462
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11453646
80mitotic spindle checkpoint (GO:0071174)3.11098522
81transcription initiation from RNA polymerase I promoter (GO:0006361)3.11081886
82resolution of meiotic recombination intermediates (GO:0000712)3.06885692
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06723099
84double-strand break repair via homologous recombination (GO:0000724)3.06559989
85DNA replication-independent nucleosome assembly (GO:0006336)3.04621204
86DNA replication-independent nucleosome organization (GO:0034724)3.04621204
87DNA unwinding involved in DNA replication (GO:0006268)3.04066547
88regulation of telomere maintenance via telomerase (GO:0032210)3.02596464
89histone H4-K12 acetylation (GO:0043983)3.01790806
90regulation of helicase activity (GO:0051095)3.01004779
91establishment of chromosome localization (GO:0051303)3.00855047
92IMP biosynthetic process (GO:0006188)3.00528398
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.99475219
94regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98739739
95centriole assembly (GO:0098534)2.97576315
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97258614
97mitochondrial RNA metabolic process (GO:0000959)2.97174806
98deoxyribonucleotide biosynthetic process (GO:0009263)2.96972540
99regulation of DNA endoreduplication (GO:0032875)2.96348711
100regulation of mitotic sister chromatid separation (GO:0010965)2.96306482
101regulation of mitotic sister chromatid segregation (GO:0033047)2.96306482
102regulation of sister chromatid segregation (GO:0033045)2.96306482
103DNA replication (GO:0006260)2.95984721
104histone H2A acetylation (GO:0043968)2.93306762
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91440691
106histone exchange (GO:0043486)2.90934133
107ATP synthesis coupled proton transport (GO:0015986)2.89840126
108energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89840126
109postreplication repair (GO:0006301)2.89648464
110regulation of centrosome cycle (GO:0046605)2.89214095
111ribonucleoprotein complex biogenesis (GO:0022613)2.88722623
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88339739
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87730321
114meiotic chromosome segregation (GO:0045132)2.85572819
115telomere maintenance (GO:0000723)2.85434268
116centriole replication (GO:0007099)2.85223896
117RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84500019
118deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84287762
119spliceosomal snRNP assembly (GO:0000387)2.84184556
120telomere organization (GO:0032200)2.83600025
121somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83011206
122somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83011206
123isotype switching (GO:0045190)2.83011206
124reciprocal DNA recombination (GO:0035825)2.81792078
125reciprocal meiotic recombination (GO:0007131)2.81792078
126DNA recombination (GO:0006310)2.81747879
127microtubule depolymerization (GO:0007019)2.81456813
128* negative regulation of DNA-dependent DNA replication (GO:2000104)2.81275689
129regulation of glucokinase activity (GO:0033131)2.80723852
130regulation of hexokinase activity (GO:1903299)2.80723852
131mitochondrial respiratory chain complex assembly (GO:0033108)2.80407850
132replication fork processing (GO:0031297)2.80301272
133L-serine metabolic process (GO:0006563)2.79123024
134attachment of spindle microtubules to kinetochore (GO:0008608)2.79098474
135viral mRNA export from host cell nucleus (GO:0046784)2.78861461
136negative regulation of ligase activity (GO:0051352)2.78497639
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78497639
138inner cell mass cell proliferation (GO:0001833)2.78454945
139mitotic sister chromatid segregation (GO:0000070)2.78000864
140non-recombinational repair (GO:0000726)2.77270778
141double-strand break repair via nonhomologous end joining (GO:0006303)2.77270778
142cytochrome complex assembly (GO:0017004)2.77256432
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77151279
144regulation of chromosome segregation (GO:0051983)2.76178342
145negative regulation of telomere maintenance (GO:0032205)2.75746904
146rRNA processing (GO:0006364)2.74011025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81087435
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75217268
3* FOXM1_23109430_ChIP-Seq_U2OS_Human3.62270950
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59484401
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.54113295
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50527700
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18610748
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.07425457
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.00891372
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.94948558
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.77677106
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70260137
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55088580
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54525573
15VDR_23849224_ChIP-Seq_CD4+_Human2.50988191
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48870989
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47514674
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47239492
19ZNF274_21170338_ChIP-Seq_K562_Hela2.43870166
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36861836
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35526661
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.34151660
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30998332
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26222844
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19495589
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19008001
27* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.16085821
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06720479
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05877812
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.05352770
31FOXP3_21729870_ChIP-Seq_TREG_Human2.04974770
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98698586
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98597136
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.90772971
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90615161
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88966803
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88385519
38ELK1_19687146_ChIP-ChIP_HELA_Human1.88173644
39CIITA_25753668_ChIP-Seq_RAJI_Human1.87716332
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87297518
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81969047
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.79038187
43EWS_26573619_Chip-Seq_HEK293_Human1.75247968
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.73635629
45DCP1A_22483619_ChIP-Seq_HELA_Human1.71452106
46XRN2_22483619_ChIP-Seq_HELA_Human1.70483097
47GABP_19822575_ChIP-Seq_HepG2_Human1.67626978
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67517277
49AR_21909140_ChIP-Seq_LNCAP_Human1.61549867
50TTF2_22483619_ChIP-Seq_HELA_Human1.60994030
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59936261
52VDR_22108803_ChIP-Seq_LS180_Human1.56302092
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53606349
54FUS_26573619_Chip-Seq_HEK293_Human1.49451204
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45427308
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45073454
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43268527
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41465236
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39946791
60IGF1R_20145208_ChIP-Seq_DFB_Human1.38463851
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.37132238
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35628012
63* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34548785
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33622076
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30137192
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29896080
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29896080
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29896080
69* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29375700
70* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27027038
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.26343378
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25207598
73KDM5A_27292631_Chip-Seq_BREAST_Human1.19173067
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17171019
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12164974
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10066074
77TAF15_26573619_Chip-Seq_HEK293_Human1.07085523
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06124817
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05053803
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04050165
81* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03848468
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01835839
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00558707
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00174800
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99632377
86* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98724720
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.97054113
88GATA1_22025678_ChIP-Seq_K562_Human0.96189930
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94497497
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93329016
91TP53_22573176_ChIP-Seq_HFKS_Human0.93258137
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92552499
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92170832
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91826565
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90822757
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89651350
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89021891
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88657785
99P300_19829295_ChIP-Seq_ESCs_Human0.87341875
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85756983
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85128740
102TFEB_21752829_ChIP-Seq_HELA_Human0.84964317
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.84310327
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84210296
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83818373
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82696137
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82108223
108IRF1_19129219_ChIP-ChIP_H3396_Human0.81708821
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.81422860
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80670421
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79524114
112* SPI1_23547873_ChIP-Seq_NB4_Human0.78477290
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78048910
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77655074
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77295821
116FOXA1_25329375_ChIP-Seq_VCAP_Human0.77295821
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.77249137
118MYC_18940864_ChIP-ChIP_HL60_Human0.76299857
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76129326
120CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75763748
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74361135
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.73946466
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72277036
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71897285
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.69265707
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68698474
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68355785
128HOXB7_26014856_ChIP-Seq_BT474_Human0.66704241
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.65100941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35798124
2* MP0003111_abnormal_nucleus_morphology4.59440482
3MP0008058_abnormal_DNA_repair4.23519463
4MP0010094_abnormal_chromosome_stability3.86722892
5MP0008057_abnormal_DNA_replication3.68669935
6* MP0003077_abnormal_cell_cycle3.13140172
7MP0006292_abnormal_olfactory_placode2.85965065
8MP0004957_abnormal_blastocyst_morpholog2.75122129
9MP0003786_premature_aging2.70889338
10MP0008007_abnormal_cellular_replicative2.69559585
11MP0003941_abnormal_skin_development2.69133941
12MP0003718_maternal_effect2.60594987
13MP0008260_abnormal_autophagy2.37773052
14MP0008877_abnormal_DNA_methylation2.31891097
15MP0001188_hyperpigmentation2.25621629
16MP0008932_abnormal_embryonic_tissue2.21058815
17MP0004147_increased_porphyrin_level2.14788664
18MP0006072_abnormal_retinal_apoptosis1.90756787
19MP0002396_abnormal_hematopoietic_system1.87016695
20MP0002160_abnormal_reproductive_system1.82431293
21MP0005377_hearing/vestibular/ear_phenot1.74631393
22MP0003878_abnormal_ear_physiology1.74631393
23MP0005389_reproductive_system_phenotype1.73823706
24MP0000566_synostosis1.70123894
25MP0002102_abnormal_ear_morphology1.70011733
26MP0002277_abnormal_respiratory_mucosa1.68724783
27MP0000015_abnormal_ear_pigmentation1.60687943
28MP0002132_abnormal_respiratory_system1.58590103
29MP0005075_abnormal_melanosome_morpholog1.54846849
30MP0003195_calcinosis1.50959379
31MP0003806_abnormal_nucleotide_metabolis1.49782458
32MP0001919_abnormal_reproductive_system1.42958821
33MP0006035_abnormal_mitochondrial_morpho1.42058758
34MP0000490_abnormal_crypts_of1.39507834
35MP0002210_abnormal_sex_determination1.36157847
36MP0005395_other_phenotype1.36079068
37MP0000350_abnormal_cell_proliferation1.33799787
38MP0003646_muscle_fatigue1.32309159
39MP0001986_abnormal_taste_sensitivity1.27494255
40MP0002837_dystrophic_cardiac_calcinosis1.25054365
41MP0009697_abnormal_copulation1.23966574
42MP0005551_abnormal_eye_electrophysiolog1.22870577
43MP0001186_pigmentation_phenotype1.21371141
44MP0003136_yellow_coat_color1.21228649
45* MP0000313_abnormal_cell_death1.20323364
46MP0003119_abnormal_digestive_system1.18365411
47MP0008789_abnormal_olfactory_epithelium1.16744188
48MP0002163_abnormal_gland_morphology1.16375216
49MP0002736_abnormal_nociception_after1.15638077
50MP0001145_abnormal_male_reproductive1.14533981
51MP0001119_abnormal_female_reproductive1.13810253
52MP0003315_abnormal_perineum_morphology1.13628355
53MP0001672_abnormal_embryogenesis/_devel1.13571019
54MP0005380_embryogenesis_phenotype1.13571019
55MP0001529_abnormal_vocalization1.12861359
56MP0003567_abnormal_fetal_cardiomyocyte1.10957530
57MP0000631_abnormal_neuroendocrine_gland1.09387237
58MP0000678_abnormal_parathyroid_gland1.09149440
59MP0004381_abnormal_hair_follicle1.08780743
60MP0002254_reproductive_system_inflammat1.08153547
61MP0005409_darkened_coat_color1.07910528
62MP0005253_abnormal_eye_physiology1.07618352
63MP0002234_abnormal_pharynx_morphology1.07496315
64MP0006036_abnormal_mitochondrial_physio1.06369174
65MP0001929_abnormal_gametogenesis1.05983894
66MP0008995_early_reproductive_senescence1.05631981
67MP0008872_abnormal_physiological_respon1.04144259
68MP0002084_abnormal_developmental_patter1.03913872
69MP0005171_absent_coat_pigmentation1.03870599
70MP0002095_abnormal_skin_pigmentation1.03354090
71MP0005084_abnormal_gallbladder_morpholo1.02520779
72MP0000653_abnormal_sex_gland1.02137988
73MP0000371_diluted_coat_color1.01408129
74MP0001730_embryonic_growth_arrest1.01289596
75MP0003698_abnormal_male_reproductive1.00976472
76MP0003186_abnormal_redox_activity1.00974265
77MP0002075_abnormal_coat/hair_pigmentati0.98920478
78MP0002876_abnormal_thyroid_physiology0.98217921
79MP0004808_abnormal_hematopoietic_stem0.97742103
80MP0010030_abnormal_orbit_morphology0.97714456
81MP0004133_heterotaxia0.93637301
82MP0002085_abnormal_embryonic_tissue0.92989843
83MP0004264_abnormal_extraembryonic_tissu0.92454660
84MP0004019_abnormal_vitamin_homeostasis0.91211891
85MP0000358_abnormal_cell_content/0.90593669
86MP0003984_embryonic_growth_retardation0.88840908
87MP0000427_abnormal_hair_cycle0.88612917
88MP0003890_abnormal_embryonic-extraembry0.87451080
89MP0010307_abnormal_tumor_latency0.87340827
90MP0005257_abnormal_intraocular_pressure0.86930994
91MP0005394_taste/olfaction_phenotype0.86926552
92MP0005499_abnormal_olfactory_system0.86926552
93MP0005645_abnormal_hypothalamus_physiol0.86284762
94* MP0002019_abnormal_tumor_incidence0.85350903
95MP0002938_white_spotting0.85218175
96MP0000647_abnormal_sebaceous_gland0.84903400
97MP0000372_irregular_coat_pigmentation0.84489974
98MP0002088_abnormal_embryonic_growth/wei0.83706789
99MP0002080_prenatal_lethality0.83607998
100MP0002638_abnormal_pupillary_reflex0.83360939
101MP0002653_abnormal_ependyma_morphology0.82810162
102MP0009703_decreased_birth_body0.82758204
103MP0002751_abnormal_autonomic_nervous0.81070765
104MP0001764_abnormal_homeostasis0.81061342
105MP0009672_abnormal_birth_weight0.79965403
106MP0002233_abnormal_nose_morphology0.79869580
107MP0010352_gastrointestinal_tract_polyps0.79841905
108MP0000613_abnormal_salivary_gland0.79214788
109MP0001968_abnormal_touch/_nociception0.79018264
110MP0001697_abnormal_embryo_size0.78281531
111MP0003787_abnormal_imprinting0.77664589
112MP0003011_delayed_dark_adaptation0.77503688
113MP0005379_endocrine/exocrine_gland_phen0.77441980
114MP0005397_hematopoietic_system_phenotyp0.77308121
115MP0001545_abnormal_hematopoietic_system0.77308121
116MP0004197_abnormal_fetal_growth/weight/0.76674659
117MP0003123_paternal_imprinting0.76248470
118MP0003121_genomic_imprinting0.76181453
119MP0003763_abnormal_thymus_physiology0.76179482
120MP0005410_abnormal_fertilization0.76159572
121MP0001485_abnormal_pinna_reflex0.75930948
122MP0001324_abnormal_eye_pigmentation0.75767638
123* MP0005384_cellular_phenotype0.74766918
124MP0000703_abnormal_thymus_morphology0.74754570
125MP0005391_vision/eye_phenotype0.74676800
126MP0005670_abnormal_white_adipose0.73349106
127MP0002111_abnormal_tail_morphology0.73236028
128MP0009333_abnormal_splenocyte_physiolog0.72656424
129MP0001286_abnormal_eye_development0.72467239
130MP0005174_abnormal_tail_pigmentation0.70756187
131MP0001293_anophthalmia0.70492491
132MP0010386_abnormal_urinary_bladder0.69605395
133* MP0005621_abnormal_cell_physiology0.69483751
134MP0002086_abnormal_extraembryonic_tissu0.68045307
135MP0003699_abnormal_female_reproductive0.67433486
136MP0003937_abnormal_limbs/digits/tail_de0.63273854
137MP0002098_abnormal_vibrissa_morphology0.62799677
138MP0002722_abnormal_immune_system0.62523951

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.29310628
2Chromsome breakage (HP:0040012)4.98475895
3Birth length less than 3rd percentile (HP:0003561)4.75734095
4Breast hypoplasia (HP:0003187)4.39617859
5Colon cancer (HP:0003003)3.74447552
6Meckel diverticulum (HP:0002245)3.59265079
7Abnormality of the preputium (HP:0100587)3.48167690
8Abnormality of the ileum (HP:0001549)3.38661049
9Abnormality of chromosome stability (HP:0003220)3.35616945
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.30795226
11Abnormality of the labia minora (HP:0012880)3.28218284
12Impulsivity (HP:0100710)3.19522879
13Abnormality of the renal collecting system (HP:0004742)3.14989295
14Duplicated collecting system (HP:0000081)3.13456066
15Pancreatic fibrosis (HP:0100732)2.93401865
16Aplasia/Hypoplasia of the patella (HP:0006498)2.92497644
17Patellar aplasia (HP:0006443)2.90647610
18Pancreatic cysts (HP:0001737)2.89793487
19Rough bone trabeculation (HP:0100670)2.83506934
20Renal cortical cysts (HP:0000803)2.82059954
21Acute necrotizing encephalopathy (HP:0006965)2.79449874
22Acute encephalopathy (HP:0006846)2.73766134
23Increased CSF lactate (HP:0002490)2.73346109
24Increased hepatocellular lipid droplets (HP:0006565)2.72776741
25Lipid accumulation in hepatocytes (HP:0006561)2.68323942
26Carpal bone hypoplasia (HP:0001498)2.68110832
27Bone marrow hypocellularity (HP:0005528)2.64750881
28Breech presentation (HP:0001623)2.64179053
29Duodenal stenosis (HP:0100867)2.62123549
30Small intestinal stenosis (HP:0012848)2.62123549
31Pendular nystagmus (HP:0012043)2.60162350
32Mitochondrial inheritance (HP:0001427)2.58680847
33Clubbing of toes (HP:0100760)2.58424867
34Ectopic kidney (HP:0000086)2.51338486
35Hyperglycinemia (HP:0002154)2.50419637
36Abnormal mitochondria in muscle tissue (HP:0008316)2.49384564
37Absent radius (HP:0003974)2.46707081
38Abnormality of the pons (HP:0007361)2.46258936
39Proximal tubulopathy (HP:0000114)2.45727422
40Ureteral duplication (HP:0000073)2.44274632
41Granulocytopenia (HP:0001913)2.44009731
42True hermaphroditism (HP:0010459)2.42697729
43Abnormality of DNA repair (HP:0003254)2.42568594
44Hypoplasia of the pons (HP:0012110)2.42527417
45Type I transferrin isoform profile (HP:0003642)2.42350466
46Osteomalacia (HP:0002749)2.40061521
47Homocystinuria (HP:0002156)2.39064143
48Abnormality of homocysteine metabolism (HP:0010919)2.39064143
49Prostate neoplasm (HP:0100787)2.38752397
50Cheilitis (HP:0100825)2.38301576
51Progressive muscle weakness (HP:0003323)2.34537685
52Abnormal spermatogenesis (HP:0008669)2.34379382
53Increased serum lactate (HP:0002151)2.32798738
54Progressive external ophthalmoplegia (HP:0000590)2.32762943
55Myelodysplasia (HP:0002863)2.32439979
56Abnormality of the carotid arteries (HP:0005344)2.31047563
57Absent thumb (HP:0009777)2.30291422
58Megaloblastic anemia (HP:0001889)2.29965738
59Molar tooth sign on MRI (HP:0002419)2.29871585
60Abnormality of midbrain morphology (HP:0002418)2.29871585
61Hepatocellular necrosis (HP:0001404)2.29021868
62Aplasia/Hypoplasia of the earlobes (HP:0009906)2.27599788
63Aplasia involving forearm bones (HP:0009822)2.24893844
64Absent forearm bone (HP:0003953)2.24893844
65Abnormal number of erythroid precursors (HP:0012131)2.24656371
66Nephronophthisis (HP:0000090)2.24194237
67Progressive macrocephaly (HP:0004481)2.23574245
68Abnormal trabecular bone morphology (HP:0100671)2.22877809
69Hyperglycinuria (HP:0003108)2.19821381
70Degeneration of anterior horn cells (HP:0002398)2.18536747
71Abnormality of the anterior horn cell (HP:0006802)2.18536747
72Abnormality of serum amino acid levels (HP:0003112)2.18364729
73Abnormality of alanine metabolism (HP:0010916)2.17408570
74Hyperalaninemia (HP:0003348)2.17408570
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17408570
76Sloping forehead (HP:0000340)2.17312651
77Abnormality of the duodenum (HP:0002246)2.11997506
78Hepatic necrosis (HP:0002605)2.10917037
79Abnormality of cells of the erythroid lineage (HP:0012130)2.10812360
80Premature graying of hair (HP:0002216)2.10650447
81Cystic liver disease (HP:0006706)2.09846839
82Facial cleft (HP:0002006)2.09336055
83Hypoplasia of the fovea (HP:0007750)2.03985227
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.03985227
85Embryonal renal neoplasm (HP:0011794)2.02995791
86Cerebral edema (HP:0002181)2.02774163
87Abnormality of serine family amino acid metabolism (HP:0010894)2.01220425
88Abnormality of glycine metabolism (HP:0010895)2.01220425
89Abnormal biliary tract physiology (HP:0012439)2.00362907
90Bile duct proliferation (HP:0001408)2.00362907
91Azoospermia (HP:0000027)1.99549223
92Aplasia/hypoplasia of the uterus (HP:0008684)1.99368706
93Microvesicular hepatic steatosis (HP:0001414)1.97950981
94Ependymoma (HP:0002888)1.97157816
95Triphalangeal thumb (HP:0001199)1.95200516
96Aplastic anemia (HP:0001915)1.95035304
97Methylmalonic acidemia (HP:0002912)1.94085151
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93855123
99Lactic acidosis (HP:0003128)1.93534605
100Long foot (HP:0001833)1.93083889
101Supernumerary spleens (HP:0009799)1.92279339
102Prolonged neonatal jaundice (HP:0006579)1.92256132
103Median cleft lip (HP:0000161)1.91918876
104Congenital stationary night blindness (HP:0007642)1.91719132
105Abnormality of the renal cortex (HP:0011035)1.91695697
106Volvulus (HP:0002580)1.91533537
107Lip pit (HP:0100267)1.89870338
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88693041
109Short thumb (HP:0009778)1.88670381
110Intestinal atresia (HP:0011100)1.87568871
111Sclerocornea (HP:0000647)1.87302052
112Abnormal protein glycosylation (HP:0012346)1.87109200
113Abnormal glycosylation (HP:0012345)1.87109200
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87109200
115Abnormal protein N-linked glycosylation (HP:0012347)1.87109200
116Oligohydramnios (HP:0001562)1.87065230
117Reticulocytopenia (HP:0001896)1.86980763
118Cerebral hypomyelination (HP:0006808)1.86628293
119Abnormality of methionine metabolism (HP:0010901)1.85363922
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84511232
121Dandy-Walker malformation (HP:0001305)1.83636491
122Abnormality of the renal medulla (HP:0100957)1.81945619
123Glucose intolerance (HP:0000833)1.81562301
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80570015
125Septo-optic dysplasia (HP:0100842)1.79841536
126Abolished electroretinogram (ERG) (HP:0000550)1.79763536
127Spinal muscular atrophy (HP:0007269)1.79519388
128Oral leukoplakia (HP:0002745)1.79257626
129Bilateral microphthalmos (HP:0007633)1.79141936
130Tracheoesophageal fistula (HP:0002575)1.78972929
131Renal Fanconi syndrome (HP:0001994)1.77249824
132Horseshoe kidney (HP:0000085)1.76763040
133Type II lissencephaly (HP:0007260)1.75987468
1343-Methylglutaconic aciduria (HP:0003535)1.74867827
135Anal stenosis (HP:0002025)1.74505580
136Methylmalonic aciduria (HP:0012120)1.73022744
137IgM deficiency (HP:0002850)1.72345210
138Anencephaly (HP:0002323)1.72293124
139Entropion (HP:0000621)1.71272217
140Congenital, generalized hypertrichosis (HP:0004540)1.70881205
141Cerebellar dysplasia (HP:0007033)1.69681966
142Medial flaring of the eyebrow (HP:0010747)1.68917672
143Microretrognathia (HP:0000308)1.67623269
144Hypoplasia of the radius (HP:0002984)1.66330621
145Eosinophilia (HP:0001880)1.65981188
146* Neoplasm of the colon (HP:0100273)1.65676281
147Sparse eyelashes (HP:0000653)1.65602572
14811 pairs of ribs (HP:0000878)1.65549786
149Fetal akinesia sequence (HP:0001989)1.65294496
150Breast aplasia (HP:0100783)1.65005154
151Acute lymphatic leukemia (HP:0006721)1.64866057
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64835977
153Type 2 muscle fiber atrophy (HP:0003554)1.63987078
154Absent hand (HP:0004050)1.63271949
155Convex nasal ridge (HP:0000444)1.63197703
156Unilateral renal agenesis (HP:0000122)1.62504227
157Preaxial hand polydactyly (HP:0001177)1.62450664
158Reduced antithrombin III activity (HP:0001976)1.60672031
159Nephroblastoma (Wilms tumor) (HP:0002667)1.58526451
160Pancytopenia (HP:0001876)1.58218201
161Abnormal lung lobation (HP:0002101)1.57455851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.66262752
2PLK44.70620316
3BUB14.60546874
4STK163.60306592
5VRK23.14944439
6WEE13.02189606
7IRAK43.01579416
8EPHA22.87630212
9SRPK12.82081745
10AKT32.73722264
11PBK2.38489483
12MARK12.38106603
13BMPR1B2.27328358
14TSSK62.23926268
15WNK31.98759176
16MAP4K21.95571026
17MST41.87187765
18IRAK21.85780862
19TAF11.84880545
20EIF2AK31.83886539
21IRAK11.77723649
22STK38L1.75488101
23NEK21.67972600
24TRIM281.57630387
25* PLK11.55934807
26MKNK21.52694568
27EIF2AK11.47524578
28EIF2AK21.40504923
29VRK11.36249871
30CDC71.35840832
31BRD41.35106423
32DYRK31.34987531
33* ATR1.34264736
34BRSK21.32966871
35WNK41.27900303
36MKNK11.26799002
37INSRR1.25574786
38PNCK1.21273365
39AURKB1.14830560
40TGFBR11.13392338
41PINK11.13363766
42* TTK1.08703799
43PRKCI1.08617251
44TXK1.04389430
45AURKA1.00982729
46BCKDK1.00039671
47TAOK20.99580094
48* PLK30.99572470
49ACVR1B0.94547801
50CDK70.92670645
51NUAK10.89227882
52STK40.86957734
53BRSK10.86528438
54CDK30.86293337
55CHEK10.86140553
56NEK10.86004450
57BRAF0.85888635
58OXSR10.84782244
59MAP3K40.82795240
60* ZAK0.82631900
61PLK20.80955896
62CSNK1G10.80414490
63TNIK0.76927866
64NEK60.76439084
65TLK10.74586770
66STK390.73538674
67CSNK1G30.73313474
68PIM20.72648506
69* CHEK20.71288089
70PASK0.68516969
71* ATM0.67816158
72TEC0.67011325
73CDK120.66060331
74PDK20.61322332
75RPS6KB20.60697701
76NME20.59210145
77CSNK1G20.57973159
78RPS6KA40.57579339
79PIM10.57441651
80STK30.57320970
81CSNK1A1L0.57254398
82TIE10.56306133
83NLK0.55590132
84ERBB30.55409130
85CDK20.55361053
86BCR0.54125872
87IKBKB0.53975809
88CHUK0.52793501
89RPS6KA50.52771961
90ADRBK20.52407503
91CCNB10.51839081
92LATS10.51659561
93CDK190.49831039
94YES10.48889770
95GRK10.48390469
96CSNK2A10.47896039
97BMPR20.46363388
98MAPK130.45901380
99ALK0.45678098
100CDC42BPA0.45336247
101MAP3K80.45279372
102* CDK10.43600719
103MUSK0.43502512
104MAPKAPK50.38641219
105MAP3K140.37252327
106CLK10.36590863
107TESK20.36315756
108MELK0.36233485
109PRKCG0.34862901
110DYRK20.34636531
111MAPK70.34621699
112SGK20.34283818
113MAP3K30.34122832
114* CSNK1E0.33375468
115CASK0.32685833
116FLT30.32230216
117* PRKDC0.32122418
118CSNK2A20.31934778
119MAP2K70.31588091
120STK240.30415333
121FGFR20.29841281
122STK380.29476916
123OBSCN0.28689014
124CAMK2D0.27708817
125NME10.27306989
126DAPK10.26254037
127CDK40.25503834
128FRK0.23111917
129MAPK140.22402243
130KDR0.20419295
131CDK80.20149477
132AKT10.19633733
133MAP2K20.19199261
134PRPF4B0.18345035
135EPHA30.17952618
136PAK40.17812322

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.92399193
2RNA polymerase_Homo sapiens_hsa030203.72985050
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46461343
4Mismatch repair_Homo sapiens_hsa034303.44464472
5Fanconi anemia pathway_Homo sapiens_hsa034603.25399166
6Vitamin B6 metabolism_Homo sapiens_hsa007503.20175336
7Homologous recombination_Homo sapiens_hsa034403.06623228
8Proteasome_Homo sapiens_hsa030503.03590233
9Base excision repair_Homo sapiens_hsa034102.73223577
10Pyrimidine metabolism_Homo sapiens_hsa002402.69496381
11Nucleotide excision repair_Homo sapiens_hsa034202.56772181
12RNA transport_Homo sapiens_hsa030132.45315222
13Spliceosome_Homo sapiens_hsa030402.42962155
14* Cell cycle_Homo sapiens_hsa041102.25395836
15Basal transcription factors_Homo sapiens_hsa030222.13919068
16Oxidative phosphorylation_Homo sapiens_hsa001902.11935207
17One carbon pool by folate_Homo sapiens_hsa006701.99529556
18Non-homologous end-joining_Homo sapiens_hsa034501.88291007
19Parkinsons disease_Homo sapiens_hsa050121.86565982
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77871099
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77448168
22Purine metabolism_Homo sapiens_hsa002301.75494551
23* p53 signaling pathway_Homo sapiens_hsa041151.72832781
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64251010
25RNA degradation_Homo sapiens_hsa030181.60181306
26Ribosome_Homo sapiens_hsa030101.59134277
27Regulation of autophagy_Homo sapiens_hsa041401.58692863
28Propanoate metabolism_Homo sapiens_hsa006401.51953391
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51516545
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46182729
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44767653
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41983708
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41204078
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40580513
35Folate biosynthesis_Homo sapiens_hsa007901.33562839
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32497581
37mRNA surveillance pathway_Homo sapiens_hsa030151.28348739
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17339267
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16200954
40Vitamin digestion and absorption_Homo sapiens_hsa049771.15734915
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.14021322
42Fatty acid elongation_Homo sapiens_hsa000621.09396513
43Pyruvate metabolism_Homo sapiens_hsa006201.07905230
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.07821520
45Butanoate metabolism_Homo sapiens_hsa006501.03644153
46Alzheimers disease_Homo sapiens_hsa050101.01438646
47Protein export_Homo sapiens_hsa030601.00909757
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.00606610
49Steroid biosynthesis_Homo sapiens_hsa001000.99629621
50Nitrogen metabolism_Homo sapiens_hsa009100.95989946
51Arachidonic acid metabolism_Homo sapiens_hsa005900.94415794
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94001887
53Circadian rhythm_Homo sapiens_hsa047100.93805824
54Herpes simplex infection_Homo sapiens_hsa051680.92722027
55Other glycan degradation_Homo sapiens_hsa005110.86578842
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79565159
57Tryptophan metabolism_Homo sapiens_hsa003800.78789549
58Glutathione metabolism_Homo sapiens_hsa004800.73213974
59Sphingolipid metabolism_Homo sapiens_hsa006000.70864840
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69880028
61Biosynthesis of amino acids_Homo sapiens_hsa012300.69858798
62Peroxisome_Homo sapiens_hsa041460.68341569
63Pentose phosphate pathway_Homo sapiens_hsa000300.68120098
64Primary immunodeficiency_Homo sapiens_hsa053400.67110370
65Selenocompound metabolism_Homo sapiens_hsa004500.65515635
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65067612
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64055301
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.63019787
69Caffeine metabolism_Homo sapiens_hsa002320.59949303
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59220316
71Systemic lupus erythematosus_Homo sapiens_hsa053220.57897255
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57083802
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56945611
74Carbon metabolism_Homo sapiens_hsa012000.56793047
75Viral carcinogenesis_Homo sapiens_hsa052030.56483619
76Antigen processing and presentation_Homo sapiens_hsa046120.56274997
77Phototransduction_Homo sapiens_hsa047440.55584090
78Ether lipid metabolism_Homo sapiens_hsa005650.53761862
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52776846
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.52577284
81Measles_Homo sapiens_hsa051620.52112491
82Sulfur metabolism_Homo sapiens_hsa009200.51412041
83Fatty acid metabolism_Homo sapiens_hsa012120.50694070
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50437236
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50289396
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.49217768
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47985364
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47766048
89Linoleic acid metabolism_Homo sapiens_hsa005910.47146793
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47079831
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45891757
92Hematopoietic cell lineage_Homo sapiens_hsa046400.45307301
93Fructose and mannose metabolism_Homo sapiens_hsa000510.43661146
94* HTLV-I infection_Homo sapiens_hsa051660.43373150
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43280424
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43263986
97Cardiac muscle contraction_Homo sapiens_hsa042600.42850099
98Galactose metabolism_Homo sapiens_hsa000520.42520662
99beta-Alanine metabolism_Homo sapiens_hsa004100.40784136
100Oocyte meiosis_Homo sapiens_hsa041140.40663288
101Autoimmune thyroid disease_Homo sapiens_hsa053200.40273787
102Metabolic pathways_Homo sapiens_hsa011000.39692419
103Apoptosis_Homo sapiens_hsa042100.39509740
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.38174363
105Lysine degradation_Homo sapiens_hsa003100.37248959
106Fatty acid degradation_Homo sapiens_hsa000710.36859823
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.35925510
108FoxO signaling pathway_Homo sapiens_hsa040680.35262835
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34700358
110Olfactory transduction_Homo sapiens_hsa047400.34372915
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31274663
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31252536
113N-Glycan biosynthesis_Homo sapiens_hsa005100.31025386
114Basal cell carcinoma_Homo sapiens_hsa052170.30840330
115Retinol metabolism_Homo sapiens_hsa008300.30308938
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29297098
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28262413
118Arginine and proline metabolism_Homo sapiens_hsa003300.27065008
119Influenza A_Homo sapiens_hsa051640.27024381
120Huntingtons disease_Homo sapiens_hsa050160.26206938
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.26162837
122Renin-angiotensin system_Homo sapiens_hsa046140.25682755
123Graft-versus-host disease_Homo sapiens_hsa053320.25468533
124Chemical carcinogenesis_Homo sapiens_hsa052040.25212526
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24553999
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24527862
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.23510058
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22466690
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22317704
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21454199
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21351738
132Prostate cancer_Homo sapiens_hsa052150.20179894
133Notch signaling pathway_Homo sapiens_hsa043300.19137398
134Small cell lung cancer_Homo sapiens_hsa052220.18905718
135Legionellosis_Homo sapiens_hsa051340.18375500
136Hippo signaling pathway_Homo sapiens_hsa043900.17351300
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17148020
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16274816
139Sulfur relay system_Homo sapiens_hsa041220.16160039
140Lysosome_Homo sapiens_hsa041420.15737605
141Allograft rejection_Homo sapiens_hsa053300.15030478
142Mineral absorption_Homo sapiens_hsa049780.14978919
143MicroRNAs in cancer_Homo sapiens_hsa052060.14310148

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