CHGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.53543835
2COPI coating of Golgi vesicle (GO:0048205)6.53543835
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42328608
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81727050
5synaptic vesicle maturation (GO:0016188)4.54196039
6glycerophospholipid catabolic process (GO:0046475)4.47908487
7positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.42777990
8regulation of synaptic vesicle exocytosis (GO:2000300)4.41198479
9cellular ketone body metabolic process (GO:0046950)4.40979407
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.32078350
11endocrine pancreas development (GO:0031018)4.31029908
12peptide hormone processing (GO:0016486)4.29080922
13insulin secretion (GO:0030073)4.26105971
14protein maturation by protein folding (GO:0022417)4.23913137
15negative regulation of execution phase of apoptosis (GO:1900118)4.21671649
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.18822232
17synaptic vesicle exocytosis (GO:0016079)4.15445184
18epithelial cell fate commitment (GO:0072148)4.09320641
19negative regulation of cytosolic calcium ion concentration (GO:0051481)4.02724377
20L-alpha-amino acid transmembrane transport (GO:1902475)4.02039233
21inositol phosphate catabolic process (GO:0071545)3.93565023
22detection of calcium ion (GO:0005513)3.92865440
23ketone body metabolic process (GO:1902224)3.87972971
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.85973352
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.83085146
26regulation of synaptic vesicle transport (GO:1902803)3.82770978
27cerebellar Purkinje cell layer development (GO:0021680)3.82629114
28locomotory exploration behavior (GO:0035641)3.77530360
29inositol phosphate dephosphorylation (GO:0046855)3.72113649
30phosphorylated carbohydrate dephosphorylation (GO:0046838)3.72113649
31glutamate secretion (GO:0014047)3.68961525
32protein retention in ER lumen (GO:0006621)3.68650857
33regulation of insulin secretion (GO:0050796)3.63319658
34positive regulation of gluconeogenesis (GO:0045722)3.61214012
35water-soluble vitamin biosynthetic process (GO:0042364)3.60363013
36regulation of calcium ion-dependent exocytosis (GO:0017158)3.53134000
37auditory receptor cell differentiation (GO:0042491)3.52110785
38regulation of type B pancreatic cell apoptotic process (GO:2000674)3.51051828
39positive regulation of insulin secretion (GO:0032024)3.50335459
40chemosensory behavior (GO:0007635)3.45453810
41protein targeting to Golgi (GO:0000042)3.41325156
42neuronal action potential propagation (GO:0019227)3.41139789
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.40918282
44activation of protein kinase A activity (GO:0034199)3.38497675
45ER overload response (GO:0006983)3.37392913
46membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.36891052
47glandular epithelial cell differentiation (GO:0002067)3.36751824
48neurotransmitter secretion (GO:0007269)3.34158881
49COPII vesicle coating (GO:0048208)3.33957397
50vesicle coating (GO:0006901)3.30839657
51regulation of peptide hormone secretion (GO:0090276)3.30011275
52neuromuscular process controlling posture (GO:0050884)3.29220468
53regulation of peptide secretion (GO:0002791)3.27280457
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25454427
55toxin metabolic process (GO:0009404)3.23833119
56peptide hormone secretion (GO:0030072)3.23805338
57nitric oxide biosynthetic process (GO:0006809)3.23800918
58respiratory chain complex IV assembly (GO:0008535)3.22359139
59intra-Golgi vesicle-mediated transport (GO:0006891)3.21112997
60positive regulation of exocytosis (GO:0045921)3.20369621
61positive regulation of nuclease activity (GO:0032075)3.19632440
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17949829
63positive regulation of histone H3-K4 methylation (GO:0051571)3.17186589
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17163348
65innervation (GO:0060384)3.16672602
66vocalization behavior (GO:0071625)3.16419470
67dendritic spine morphogenesis (GO:0060997)3.15651445
68peptide secretion (GO:0002790)3.14536158
69cellular response to glucagon stimulus (GO:0071377)3.14296918
70negative regulation of hormone biosynthetic process (GO:0032353)3.11451982
71alanine transport (GO:0032328)3.10217543
72positive regulation of vesicle fusion (GO:0031340)3.09518252
73exploration behavior (GO:0035640)3.08846139
74regulation of vesicle fusion (GO:0031338)3.07883377
75establishment of protein localization to Golgi (GO:0072600)3.07368055
76positive regulation of neurotransmitter transport (GO:0051590)3.06653868
77suckling behavior (GO:0001967)3.05821889
78polyol catabolic process (GO:0046174)3.05618726
79regulation of hexokinase activity (GO:1903299)3.04972499
80regulation of glucokinase activity (GO:0033131)3.04972499
81membrane repolarization during action potential (GO:0086011)3.03674651
82neuron cell-cell adhesion (GO:0007158)3.02332895
83positive regulation of macroautophagy (GO:0016239)3.02321894
84cytochrome complex assembly (GO:0017004)3.00106058
85serotonin metabolic process (GO:0042428)2.99051234
86type B pancreatic cell development (GO:0003323)2.96778647
87regulation of neuronal synaptic plasticity (GO:0048168)2.95899847
88inner ear receptor cell development (GO:0060119)2.95514125
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94934454
90L-phenylalanine catabolic process (GO:0006559)2.94934454
91regulation of exocytosis (GO:0017157)2.94837142
92exocrine pancreas development (GO:0031017)2.94590353
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94435679
94potassium ion export (GO:0071435)2.94389311
95nitric oxide mediated signal transduction (GO:0007263)2.94275337
96positive regulation of calcium ion import (GO:0090280)2.91661927
97response to pheromone (GO:0019236)2.89897589
98retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89848784
99positive regulation of peptide secretion (GO:0002793)2.88933347
100positive regulation of peptide hormone secretion (GO:0090277)2.88495892
101regulation of glutamate receptor signaling pathway (GO:1900449)2.87982917
102regulation of extracellular matrix disassembly (GO:0010715)2.87778897
103regulation of hormone secretion (GO:0046883)2.86645395
104protein localization to Golgi apparatus (GO:0034067)2.86275542
105regulation of nuclease activity (GO:0032069)2.85158087
106signal release (GO:0023061)2.85117355
107regulation of beta-amyloid formation (GO:1902003)2.82814466
108regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.82707794
109negative regulation of catecholamine secretion (GO:0033604)2.82352708
110regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81843091
111astrocyte differentiation (GO:0048708)2.81207325
112zinc ion homeostasis (GO:0055069)2.81192631
113glandular epithelial cell development (GO:0002068)2.81033936
114peptide transport (GO:0015833)2.80869163
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80172199
116L-phenylalanine metabolic process (GO:0006558)2.80172199
117proline transport (GO:0015824)2.79934229
118cardiac left ventricle morphogenesis (GO:0003214)2.79623585
119cerebellar Purkinje cell differentiation (GO:0021702)2.79411174
120regulation of autophagic vacuole assembly (GO:2000785)2.79387823
121catecholamine transport (GO:0051937)2.78085851
122inositol phosphate-mediated signaling (GO:0048016)2.77848422
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77771778
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77256964
125nodal signaling pathway (GO:0038092)2.76850218
126regulation of neurotransmitter uptake (GO:0051580)2.76718930
127regulation of glucocorticoid secretion (GO:2000849)2.76283078
128positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73980147
129cellular potassium ion homeostasis (GO:0030007)2.73648285
130cell communication by electrical coupling (GO:0010644)2.73391399
131macroautophagy (GO:0016236)2.73066107
132neurotransmitter transport (GO:0006836)2.72179779
133vesicle transport along microtubule (GO:0047496)2.70705598
134regulation of amyloid precursor protein catabolic process (GO:1902991)2.70235154
135negative regulation of hormone metabolic process (GO:0032351)2.69501537
136endoplasmic reticulum unfolded protein response (GO:0030968)2.69269355
137long-term synaptic potentiation (GO:0060291)2.68988882
138synaptic transmission, glutamatergic (GO:0035249)2.68323954
139regulation of ARF protein signal transduction (GO:0032012)2.68222060
140hormone secretion (GO:0046879)2.66119315
141brain morphogenesis (GO:0048854)2.65967569
142phenylpropanoid metabolic process (GO:0009698)2.63541352
143regulation of heart rate by cardiac conduction (GO:0086091)2.63518749
144positive regulation of response to nutrient levels (GO:0032109)2.63352793
145positive regulation of response to extracellular stimulus (GO:0032106)2.63352793
146cellular response to unfolded protein (GO:0034620)2.62989591
147signal peptide processing (GO:0006465)2.62613196
148regulation of peptide transport (GO:0090087)2.62523741
149regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62503649
150regulation of neurotransmitter secretion (GO:0046928)2.62262450
151dopamine transport (GO:0015872)2.61624689
152pteridine-containing compound biosynthetic process (GO:0042559)2.60261210
153protein localization to synapse (GO:0035418)2.60070567
154positive regulation of hormone secretion (GO:0046887)2.58011184
155regulation of vacuole organization (GO:0044088)2.57950933
156positive regulation of glycolytic process (GO:0045821)2.57697285
157cellular zinc ion homeostasis (GO:0006882)2.54983457
158positive regulation of meiosis (GO:0045836)2.54706024
159toxin transport (GO:1901998)2.53159390
160hormone transport (GO:0009914)2.51804022
161dopamine biosynthetic process (GO:0042416)2.51430756
162retinol metabolic process (GO:0042572)2.49082591
163regulation of protein glycosylation (GO:0060049)2.48811141
164regulation of execution phase of apoptosis (GO:1900117)2.48758538
165amide transport (GO:0042886)2.48738692
166calcium ion import (GO:0070509)2.48393943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05672177
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80624573
3GBX2_23144817_ChIP-Seq_PC3_Human3.02282805
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.99872820
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66638178
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52797264
7* REST_18959480_ChIP-ChIP_MESCs_Mouse2.47215098
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41980716
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.37381631
10DROSHA_22980978_ChIP-Seq_HELA_Human2.32606646
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22737883
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21329235
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21145205
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21093014
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16467978
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16197937
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07263170
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.05199962
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.03091198
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02253563
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01631806
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01631806
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01034584
24* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.91492509
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.89969178
26ZNF274_21170338_ChIP-Seq_K562_Hela1.89201247
27* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88560505
28TAF15_26573619_Chip-Seq_HEK293_Human1.86235645
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84660328
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.74890840
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74208742
32IGF1R_20145208_ChIP-Seq_DFB_Human1.73212732
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72231189
34HTT_18923047_ChIP-ChIP_STHdh_Human1.70318888
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.70107249
36FUS_26573619_Chip-Seq_HEK293_Human1.64930441
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64766432
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.59492769
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56850990
40* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54504508
41GATA1_22025678_ChIP-Seq_K562_Human1.52596887
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52587557
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52076099
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50854499
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48230925
46STAT3_23295773_ChIP-Seq_U87_Human1.47103554
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45354501
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41148302
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38551741
50* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38068725
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.37643489
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37472820
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37212265
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34230815
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34141039
56* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33135033
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32558281
58P53_22387025_ChIP-Seq_ESCs_Mouse1.29805220
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29302056
60ER_23166858_ChIP-Seq_MCF-7_Human1.29069729
61TP53_22573176_ChIP-Seq_HFKS_Human1.27812095
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27163956
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25904659
64AR_19668381_ChIP-Seq_PC3_Human1.25699957
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25403056
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22375417
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22154523
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.22013031
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.21473968
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20315732
71* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20244230
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19412647
73* SOX2_18555785_Chip-Seq_ESCs_Mouse1.18139335
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16854722
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.16854722
76TCF4_23295773_ChIP-Seq_U87_Human1.16501591
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16251843
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15874496
79* STAT3_18555785_Chip-Seq_ESCs_Mouse1.15719684
80* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15714813
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.15026164
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14911867
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14426568
84P300_19829295_ChIP-Seq_ESCs_Human1.14184264
85* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13051252
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12277908
87CDX2_22108803_ChIP-Seq_LS180_Human1.12117208
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.11974530
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11875077
90* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10566903
91* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10048434
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09362666
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09306928
94CBP_20019798_ChIP-Seq_JUKART_Human1.09197584
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09197584
96VDR_22108803_ChIP-Seq_LS180_Human1.09004643
97TCF4_22108803_ChIP-Seq_LS180_Human1.08660536
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.07831005
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.07400163
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07375051
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06956906
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05556780
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04632667
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04440068
105* AR_25329375_ChIP-Seq_VCAP_Human1.04052195
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02596553
107* CTCF_18555785_Chip-Seq_ESCs_Mouse1.02319998
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.02149619
109* NMYC_18555785_Chip-Seq_ESCs_Mouse1.02068981
110* SOX2_19829295_ChIP-Seq_ESCs_Human1.02024186
111* NANOG_19829295_ChIP-Seq_ESCs_Human1.02024186
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00975602
113* P300_18555785_Chip-Seq_ESCs_Mouse1.00823251
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00808456
115REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00259420
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00065729
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.98955306
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98319870
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98295914
120* TAL1_26923725_Chip-Seq_HPCs_Mouse0.97954127
121KDM2B_26808549_Chip-Seq_K562_Human0.97597166
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.97596505
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97400139
124RNF2_27304074_Chip-Seq_NSC_Mouse0.97304192
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97254098
126RUNX2_22187159_ChIP-Seq_PCA_Human0.96620982
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96567867
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.96534235
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.96412783
130BCAT_22108803_ChIP-Seq_LS180_Human0.94754334
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94233637
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94145963
133* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93535996
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.93125015
135* OCT4_18555785_Chip-Seq_ESCs_Mouse0.93121913
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92723784
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.89256369
138* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88278368
139* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88168114
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87330347
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86490588
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85634863
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85127099
144AHR_22903824_ChIP-Seq_MCF-7_Human0.84863938
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83709266
146* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81731188
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80935708
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.80254533
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.79050123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.83878511
2MP0004859_abnormal_synaptic_plasticity3.59160928
3MP0003283_abnormal_digestive_organ3.45325497
4* MP0002909_abnormal_adrenal_gland3.29220042
5MP0000013_abnormal_adipose_tissue3.26351523
6MP0002877_abnormal_melanocyte_morpholog3.09868106
7MP0004043_abnormal_pH_regulation3.06229842
8MP0004270_analgesia3.03709112
9MP0010386_abnormal_urinary_bladder2.80268256
10MP0003122_maternal_imprinting2.74329504
11MP0003635_abnormal_synaptic_transmissio2.73372525
12MP0003183_abnormal_peptide_metabolism2.61996586
13MP0002139_abnormal_hepatobiliary_system2.56530339
14* MP0002693_abnormal_pancreas_physiology2.55282146
15MP0005645_abnormal_hypothalamus_physiol2.47240982
16MP0001944_abnormal_pancreas_morphology2.44938129
17MP0010234_abnormal_vibrissa_follicle2.39052173
18MP0008877_abnormal_DNA_methylation2.31271109
19MP0005379_endocrine/exocrine_gland_phen2.27071581
20MP0005646_abnormal_pituitary_gland2.16296904
21MP0003880_abnormal_central_pattern2.13687236
22MP0002063_abnormal_learning/memory/cond2.08606385
23MP0002837_dystrophic_cardiac_calcinosis2.03812646
24MP0003787_abnormal_imprinting2.03194875
25MP0009745_abnormal_behavioral_response1.99518861
26MP0002734_abnormal_mechanical_nocicepti1.99408353
27MP0002572_abnormal_emotion/affect_behav1.96996252
28MP0002064_seizures1.93824015
29MP0006072_abnormal_retinal_apoptosis1.93255534
30MP0000678_abnormal_parathyroid_gland1.87213657
31MP0001501_abnormal_sleep_pattern1.87191622
32MP0002638_abnormal_pupillary_reflex1.86122583
33MP0002272_abnormal_nervous_system1.83704428
34MP0003195_calcinosis1.82844767
35MP0009046_muscle_twitch1.82085205
36MP0002254_reproductive_system_inflammat1.76688786
37MP0010329_abnormal_lipoprotein_level1.66053392
38MP0002733_abnormal_thermal_nociception1.64083757
39* MP0002078_abnormal_glucose_homeostasis1.61412952
40MP0001756_abnormal_urination1.60114266
41MP0000003_abnormal_adipose_tissue1.59402386
42MP0004019_abnormal_vitamin_homeostasis1.58157018
43MP0008961_abnormal_basal_metabolism1.53875118
44MP0005332_abnormal_amino_acid1.53632314
45MP0001502_abnormal_circadian_rhythm1.48375244
46MP0003879_abnormal_hair_cell1.46130022
47MP0001970_abnormal_pain_threshold1.42209401
48MP0001968_abnormal_touch/_nociception1.39258414
49MP0008569_lethality_at_weaning1.36996988
50MP0004264_abnormal_extraembryonic_tissu1.35281218
51MP0002557_abnormal_social/conspecific_i1.34973814
52MP0002234_abnormal_pharynx_morphology1.34293487
53MP0001765_abnormal_ion_homeostasis1.33934648
54MP0005220_abnormal_exocrine_pancreas1.33184032
55MP0001440_abnormal_grooming_behavior1.32269736
56MP0001486_abnormal_startle_reflex1.30912707
57MP0005423_abnormal_somatic_nervous1.30679424
58MP0002067_abnormal_sensory_capabilities1.29234196
59MP0006276_abnormal_autonomic_nervous1.28289544
60MP0002184_abnormal_innervation1.27312324
61MP0003123_paternal_imprinting1.24987874
62MP0003172_abnormal_lysosome_physiology1.24648251
63MP0000631_abnormal_neuroendocrine_gland1.24505378
64MP0005535_abnormal_body_temperature1.24367219
65MP0005636_abnormal_mineral_homeostasis1.23949478
66MP0001905_abnormal_dopamine_level1.23546917
67MP0005365_abnormal_bile_salt1.23254497
68MP0000955_abnormal_spinal_cord1.21147183
69* MP0003953_abnormal_hormone_level1.20437957
70MP0004811_abnormal_neuron_physiology1.20145562
71MP0002822_catalepsy1.17999368
72MP0004858_abnormal_nervous_system1.16248823
73MP0005386_behavior/neurological_phenoty1.16208269
74MP0004924_abnormal_behavior1.16208269
75MP0002735_abnormal_chemical_nociception1.15372132
76MP0001986_abnormal_taste_sensitivity1.14684251
77MP0004145_abnormal_muscle_electrophysio1.11896080
78MP0005084_abnormal_gallbladder_morpholo1.09832867
79MP0003011_delayed_dark_adaptation1.07657227
80MP0004133_heterotaxia1.07371177
81MP0003329_amyloid_beta_deposits1.05681837
82MP0003633_abnormal_nervous_system0.99755667
83MP0001984_abnormal_olfaction0.98868009
84MP0002069_abnormal_eating/drinking_beha0.98179159
85MP0002882_abnormal_neuron_morphology0.96466150
86MP0002229_neurodegeneration0.96314894
87MP0002066_abnormal_motor_capabilities/c0.95592994
88MP0002090_abnormal_vision0.94883090
89MP0000462_abnormal_digestive_system0.94523943
90MP0005551_abnormal_eye_electrophysiolog0.94521659
91MP0005253_abnormal_eye_physiology0.94426853
92MP0002876_abnormal_thyroid_physiology0.93832487
93MP0005075_abnormal_melanosome_morpholog0.92988058
94MP0003045_fibrosis0.92649101
95MP0002896_abnormal_bone_mineralization0.91892915
96MP0004085_abnormal_heartbeat0.90439222
97MP0003121_genomic_imprinting0.89341063
98MP0002118_abnormal_lipid_homeostasis0.87989001
99MP0008872_abnormal_physiological_respon0.87840532
100MP0002736_abnormal_nociception_after0.86930140
101MP0002938_white_spotting0.86643103
102MP0005174_abnormal_tail_pigmentation0.86317418
103MP0004233_abnormal_muscle_weight0.85103872
104MP0002928_abnormal_bile_duct0.82121587
105MP0001664_abnormal_digestion0.82005174
106MP0004885_abnormal_endolymph0.81958346
107MP0000230_abnormal_systemic_arterial0.81159750
108MP0004142_abnormal_muscle_tone0.79963744
109MP0005187_abnormal_penis_morphology0.78397398
110MP0002163_abnormal_gland_morphology0.78064300
111MP0003868_abnormal_feces_composition0.78052925
112MP0005448_abnormal_energy_balance0.77798482
113MP0001299_abnormal_eye_distance/0.77631097
114MP0004215_abnormal_myocardial_fiber0.77196536
115* MP0000639_abnormal_adrenal_gland0.77181251
116MP0004147_increased_porphyrin_level0.76571760
117MP0003959_abnormal_lean_body0.75768794
118MP0005248_abnormal_Harderian_gland0.75017251
119MP0003866_abnormal_defecation0.74453297
120MP0006036_abnormal_mitochondrial_physio0.74123311
121MP0010678_abnormal_skin_adnexa0.73577111
122MP0002653_abnormal_ependyma_morphology0.73033569
123MP0000427_abnormal_hair_cycle0.72348588
124MP0005452_abnormal_adipose_tissue0.71709915
125MP0000778_abnormal_nervous_system0.71441025
126MP0003119_abnormal_digestive_system0.69784898
127MP0002751_abnormal_autonomic_nervous0.67703061
128MP0000569_abnormal_digit_pigmentation0.67164772
129MP0003631_nervous_system_phenotype0.67028269
130MP0002295_abnormal_pulmonary_circulatio0.65254145
131MP0000372_irregular_coat_pigmentation0.63920296

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.52297186
2Hyperinsulinemic hypoglycemia (HP:0000825)5.60191663
3Hypoglycemic seizures (HP:0002173)4.88334062
4Symptomatic seizures (HP:0011145)4.50256864
5Visual hallucinations (HP:0002367)4.50087836
6Agitation (HP:0000713)4.41143578
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.26313541
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.23320417
9Congenital malformation of the right heart (HP:0011723)4.01703666
10Double outlet right ventricle (HP:0001719)4.01703666
11Decreased circulating renin level (HP:0003351)3.89660989
12Focal motor seizures (HP:0011153)3.84034294
13Insulin-resistant diabetes mellitus (HP:0000831)3.69578684
14Intestinal atresia (HP:0011100)3.68895953
15Hypoglycemic coma (HP:0001325)3.66132429
16Hyperglycemia (HP:0003074)3.64159156
17Pheochromocytoma (HP:0002666)3.52601699
18Ketoacidosis (HP:0001993)3.52111286
19Abnormality of the pancreatic islet cells (HP:0006476)3.51655167
20Abnormality of endocrine pancreas physiology (HP:0012093)3.51655167
21Hypercortisolism (HP:0001578)3.34174286
22Abnormality of vitamin B metabolism (HP:0004340)3.32819752
23Atonic seizures (HP:0010819)3.31357989
24Papilledema (HP:0001085)3.19422140
25Epileptiform EEG discharges (HP:0011182)3.13575488
26Pancreatic islet-cell hyperplasia (HP:0004510)3.13225317
27EEG with generalized epileptiform discharges (HP:0011198)3.12293874
28Neuroendocrine neoplasm (HP:0100634)3.09812332
29Menstrual irregularities (HP:0000858)3.07718400
30Epileptic encephalopathy (HP:0200134)3.06461546
31Large for gestational age (HP:0001520)3.05943206
32Absence seizures (HP:0002121)3.04188358
33Hypsarrhythmia (HP:0002521)3.00433952
34Increased CSF protein (HP:0002922)2.98341754
35Focal seizures (HP:0007359)2.93633848
36Late onset (HP:0003584)2.88653483
37Ketosis (HP:0001946)2.88136907
38Abnormality of vitamin metabolism (HP:0100508)2.83246846
39Methylmalonic acidemia (HP:0002912)2.79038065
40Hyperparathyroidism (HP:0000843)2.75185414
41Abnormal pancreas size (HP:0012094)2.73993891
42Retinal atrophy (HP:0001105)2.71533474
43Urinary glycosaminoglycan excretion (HP:0003541)2.69755341
44Mucopolysacchariduria (HP:0008155)2.69755341
45Depression (HP:0000716)2.68932874
46Anxiety (HP:0000739)2.66631666
47Abnormality of renin-angiotensin system (HP:0000847)2.62209459
48Dysostosis multiplex (HP:0000943)2.60300421
49Dialeptic seizures (HP:0011146)2.59892901
50Generalized tonic-clonic seizures (HP:0002069)2.56304871
51Myokymia (HP:0002411)2.53712911
52Action tremor (HP:0002345)2.52150636
53Abnormality of polysaccharide metabolism (HP:0011012)2.51772540
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51772540
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51772540
56Restlessness (HP:0000711)2.50001413
57Macroorchidism (HP:0000053)2.48788458
58Hypokalemia (HP:0002900)2.47431802
59Adrenal overactivity (HP:0002717)2.47161718
60Progressive cerebellar ataxia (HP:0002073)2.46805680
61Progressive neurologic deterioration (HP:0002344)2.45246883
62Medial flaring of the eyebrow (HP:0010747)2.42999770
63Muscular hypotonia of the trunk (HP:0008936)2.39980227
64Impaired smooth pursuit (HP:0007772)2.37992130
65Febrile seizures (HP:0002373)2.37721641
66Progressive macrocephaly (HP:0004481)2.36296985
67Failure to thrive in infancy (HP:0001531)2.34425498
68Hypothermia (HP:0002045)2.32659970
69Limb dystonia (HP:0002451)2.32463739
70Truncal ataxia (HP:0002078)2.32415076
71Postural tremor (HP:0002174)2.31666479
72Hypokinesia (HP:0002375)2.29655084
73Increased circulating renin level (HP:0000848)2.28546435
74Polyphagia (HP:0002591)2.26639120
75Methylmalonic aciduria (HP:0012120)2.23626411
76Hypomagnesemia (HP:0002917)2.21347840
77Proximal tubulopathy (HP:0000114)2.21093086
78Hyperkalemia (HP:0002153)2.18560778
79Polydipsia (HP:0001959)2.18021989
80Abnormal drinking behavior (HP:0030082)2.18021989
81Gaze-evoked nystagmus (HP:0000640)2.16591702
82Poor suck (HP:0002033)2.15243026
83Abnormality of potassium homeostasis (HP:0011042)2.14047579
84Congenital sensorineural hearing impairment (HP:0008527)2.13188140
85Testicular neoplasm (HP:0010788)2.12669058
86Supranuclear gaze palsy (HP:0000605)2.12621601
87Growth hormone excess (HP:0000845)2.11982150
88Hypoalbuminemia (HP:0003073)2.11088143
89Abnormal albumin level (HP:0012116)2.11088143
90Glycosuria (HP:0003076)2.09104922
91Abnormality of urine glucose concentration (HP:0011016)2.09104922
92Ventricular fibrillation (HP:0001663)2.08333725
93Orthostatic hypotension (HP:0001278)2.04137844
94Acute necrotizing encephalopathy (HP:0006965)2.03839642
95Hyperphosphatemia (HP:0002905)2.01707501
96Unilateral renal agenesis (HP:0000122)2.01007786
97Abnormality of the renal cortex (HP:0011035)2.00425720
98Diminished movement (HP:0002374)1.99818470
99Dysautonomia (HP:0002459)1.99373324
100Abnormal rod and cone electroretinograms (HP:0008323)1.98916079
101Cortical visual impairment (HP:0100704)1.97296553
102Neoplasm of the heart (HP:0100544)1.96329433
103Insulin resistance (HP:0000855)1.95318741
104Intention tremor (HP:0002080)1.93992516
105Attenuation of retinal blood vessels (HP:0007843)1.93824752
106Conjugated hyperbilirubinemia (HP:0002908)1.93124841
107Vascular calcification (HP:0004934)1.91480823
108Hyperthyroidism (HP:0000836)1.91377184
109Pancreatic fibrosis (HP:0100732)1.89756388
110Gait imbalance (HP:0002141)1.89344373
111Abnormal sex determination (HP:0012244)1.88618580
112Sex reversal (HP:0012245)1.88618580
113Mesangial abnormality (HP:0001966)1.88172719
114Drooling (HP:0002307)1.86831614
115Excessive salivation (HP:0003781)1.86831614
116Congenital glaucoma (HP:0001087)1.86087656
117Amblyopia (HP:0000646)1.83358073
118Hypotension (HP:0002615)1.83151192
119Abnormal eating behavior (HP:0100738)1.82956484
120Poor eye contact (HP:0000817)1.82937570
121Nephronophthisis (HP:0000090)1.82856941
122Prominent metopic ridge (HP:0005487)1.82747576
123Hyperventilation (HP:0002883)1.80956655
124Abnormality of ocular smooth pursuit (HP:0000617)1.80598261
125Congenital primary aphakia (HP:0007707)1.79754483
126Ankle clonus (HP:0011448)1.79037437
127Hyperactive renin-angiotensin system (HP:0000841)1.77954881
128Mitochondrial inheritance (HP:0001427)1.76788044
129Type II lissencephaly (HP:0007260)1.76497782
130Psychosis (HP:0000709)1.76272432
131Pancreatic cysts (HP:0001737)1.75498315
132Urethral obstruction (HP:0000796)1.75395436
133Abnormal EKG (HP:0003115)1.75199779
134Hamartoma of the eye (HP:0010568)1.74870556
135Hemiparesis (HP:0001269)1.74507259
136Resting tremor (HP:0002322)1.74415368
137Tongue fasciculations (HP:0001308)1.74311899
138Enlarged penis (HP:0000040)1.74252756
139Conjunctival hamartoma (HP:0100780)1.72660262
140Genetic anticipation (HP:0003743)1.72633627
141Impaired vibration sensation in the lower limbs (HP:0002166)1.72173346
142Episodic fever (HP:0001954)1.71935972
143Aqueductal stenosis (HP:0002410)1.71732158
144Syncope (HP:0001279)1.70820845
145Generalized hyperpigmentation (HP:0007440)1.70126467
146Abnormal social behavior (HP:0012433)1.69705817
147Impaired social interactions (HP:0000735)1.69705817
148Prolonged QT interval (HP:0001657)1.68675190
149Dysdiadochokinesis (HP:0002075)1.68192619
150Osteomalacia (HP:0002749)1.67770050
151Hypoventilation (HP:0002791)1.67371524
152Type II diabetes mellitus (HP:0005978)1.67303076
153Limb hypertonia (HP:0002509)1.67031897
154Abnormality of the fovea (HP:0000493)1.66950807
155Abnormality of small intestinal villus morphology (HP:0011472)1.66855228
156Villous atrophy (HP:0011473)1.66855228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.35056341
2NTRK34.22360327
3TAOK33.26555592
4PASK3.18695026
5PRKD33.12990615
6PHKG13.09832218
7PHKG23.09832218
8FGFR22.82820535
9MAPK152.71777475
10MAP3K22.58462002
11UHMK12.51289490
12PINK12.45715392
13MAP3K92.40721576
14MAP4K22.40584190
15NTRK12.31968368
16HIPK22.31406072
17CAMKK22.28842800
18GRK12.27395828
19MST42.18395400
20MAP3K42.18282165
21MAP2K62.12860617
22FRK2.02759809
23WNK32.00739203
24ADRBK21.86319838
25SCYL21.78214522
26TRPM71.71602740
27AKT31.71354339
28CSNK1G11.70718303
29CASK1.64827119
30MAP2K71.62825959
31DAPK21.60894965
32CAMKK11.57987899
33EPHA41.57919725
34FGFR31.56935030
35MAP3K11.55168338
36MINK11.51167201
37PAK61.48929658
38WNK41.45306438
39MARK11.43537190
40CSNK1G31.41672388
41KSR21.36831149
42CDC42BPA1.32812501
43PRKCH1.30883658
44NLK1.24885888
45MAP2K41.18269463
46CDK51.16740176
47PAK31.15039103
48PNCK1.13079477
49GRK51.11300309
50RET1.10310938
51STK38L1.09099069
52PDGFRA1.03721886
53PTK21.02163999
54NTRK21.01436565
55DAPK11.01308190
56STK31.00060139
57ACVR1B0.98770098
58ERBB30.96049006
59PRKCG0.92616154
60ERN10.91265726
61FLT30.90620226
62WNK10.90097601
63STK240.88528905
64LMTK20.85700187
65CAMK2A0.84493740
66TAOK10.84403634
67MAP3K120.83736437
68SGK2230.81706787
69SGK4940.81706787
70BMPR1B0.79505186
71CAMK2B0.79349348
72RIPK10.78321822
73OXSR10.78228622
74FER0.77477696
75CAMK2D0.75779919
76TNK20.74444668
77PTK2B0.73498618
78ARAF0.73356582
79CDK190.73287348
80PRKCE0.72532237
81PLK20.72254670
82TNIK0.71678993
83PRKCI0.71617710
84CAMK1G0.71434722
85MKNK20.70476635
86CAMK10.69910836
87KSR10.69391931
88SGK20.68450712
89RIPK40.67888366
90BRAF0.65806537
91STK380.65138871
92YES10.64771040
93ALK0.63872924
94BRSK10.63338149
95CCNB10.62897348
96MAPK130.62307461
97STK390.61718304
98CSNK1A1L0.61215611
99PRKD20.60868395
100PRKG20.59383499
101MARK20.57135067
102SGK30.57111407
103DYRK1A0.56264552
104LIMK10.56167281
105PRKG10.53550100
106SGK10.52313508
107BMPR20.50781425
108STK110.50024179
109IRAK10.47683441
110PRKAA20.47479560
111BCR0.47181330
112DYRK1B0.46729984
113RPS6KA30.46212978
114PDPK10.45802948
115CSNK1D0.45689594
116RPS6KA20.45636671
117PDK10.45238143
118CSNK1A10.44726500
119GSK3A0.44559274
120EPHA30.44231234
121PRKACG0.42140792
122PRKACA0.41732957
123PRKAA10.41123253
124CDK140.40871829
125PRKCZ0.39297793
126MAP2K10.38489062
127PIK3CG0.38111676
128MAPK100.38043779
129PRKCA0.37971530
130CSNK1E0.37778971
131CSNK1G20.37225838
132PTK60.37134868
133IRAK20.37066138
134TRIB30.36773070
135CDK180.36604370
136ADRBK10.36438307
137FES0.35429009
138ZAK0.35226679
139CDK150.34963685
140CAMK40.33629008
141PRKACB0.33471977
142CAMK2G0.32347059
143NEK60.31779128
144PRKCB0.31578277

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.49475169
2Insulin secretion_Homo sapiens_hsa049113.40443855
3Synaptic vesicle cycle_Homo sapiens_hsa047212.71095894
4Protein export_Homo sapiens_hsa030602.50135984
5Amphetamine addiction_Homo sapiens_hsa050312.41247510
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39290294
7Folate biosynthesis_Homo sapiens_hsa007902.33368370
8Type II diabetes mellitus_Homo sapiens_hsa049302.24671262
9Vitamin B6 metabolism_Homo sapiens_hsa007502.21846377
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20339901
11Circadian entrainment_Homo sapiens_hsa047132.14088742
12Long-term potentiation_Homo sapiens_hsa047202.13968713
13Vibrio cholerae infection_Homo sapiens_hsa051102.12844776
14Cocaine addiction_Homo sapiens_hsa050302.08672370
15GABAergic synapse_Homo sapiens_hsa047272.08605780
16Nicotine addiction_Homo sapiens_hsa050332.05362393
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94401410
18Dopaminergic synapse_Homo sapiens_hsa047281.92357198
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91820744
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85759194
21Taste transduction_Homo sapiens_hsa047421.84397640
22Oxidative phosphorylation_Homo sapiens_hsa001901.84140219
23Type I diabetes mellitus_Homo sapiens_hsa049401.80360306
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79370228
25Morphine addiction_Homo sapiens_hsa050321.78657757
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73670291
27Glutamatergic synapse_Homo sapiens_hsa047241.71658136
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63950989
29Sulfur metabolism_Homo sapiens_hsa009201.63162973
30Serotonergic synapse_Homo sapiens_hsa047261.60411096
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59590470
32Cholinergic synapse_Homo sapiens_hsa047251.57577534
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52343120
34Olfactory transduction_Homo sapiens_hsa047401.50940770
35Collecting duct acid secretion_Homo sapiens_hsa049661.46897681
36Salivary secretion_Homo sapiens_hsa049701.45063018
37Gastric acid secretion_Homo sapiens_hsa049711.35031553
38Renin secretion_Homo sapiens_hsa049241.34602149
39Pancreatic secretion_Homo sapiens_hsa049721.33185763
40Selenocompound metabolism_Homo sapiens_hsa004501.30851501
41Long-term depression_Homo sapiens_hsa047301.30694748
42Thyroid hormone synthesis_Homo sapiens_hsa049181.27896284
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23560761
44Tryptophan metabolism_Homo sapiens_hsa003801.20609066
45Estrogen signaling pathway_Homo sapiens_hsa049151.16253060
46Ether lipid metabolism_Homo sapiens_hsa005651.14165657
47Fatty acid elongation_Homo sapiens_hsa000621.08520815
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06387809
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05680475
50Circadian rhythm_Homo sapiens_hsa047101.04376913
51beta-Alanine metabolism_Homo sapiens_hsa004101.03629561
52Propanoate metabolism_Homo sapiens_hsa006401.03435130
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00628768
54Glucagon signaling pathway_Homo sapiens_hsa049221.00487829
55cAMP signaling pathway_Homo sapiens_hsa040240.97678041
56GnRH signaling pathway_Homo sapiens_hsa049120.97403059
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97184163
58Oxytocin signaling pathway_Homo sapiens_hsa049210.95923749
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94409539
60Peroxisome_Homo sapiens_hsa041460.94390113
61Mineral absorption_Homo sapiens_hsa049780.94038592
62Parkinsons disease_Homo sapiens_hsa050120.93681472
63N-Glycan biosynthesis_Homo sapiens_hsa005100.92123074
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92088431
65Calcium signaling pathway_Homo sapiens_hsa040200.89019448
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.87442843
67Gap junction_Homo sapiens_hsa045400.86598076
68Lysosome_Homo sapiens_hsa041420.78450876
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77242074
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76004425
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75954004
72Arginine biosynthesis_Homo sapiens_hsa002200.75256416
73Melanogenesis_Homo sapiens_hsa049160.69846668
74Fatty acid metabolism_Homo sapiens_hsa012120.69022662
75Prion diseases_Homo sapiens_hsa050200.68608173
76Nitrogen metabolism_Homo sapiens_hsa009100.66893189
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66385271
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66369183
79Phototransduction_Homo sapiens_hsa047440.65712139
80Glioma_Homo sapiens_hsa052140.65194553
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65061897
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65021590
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64739892
84Other glycan degradation_Homo sapiens_hsa005110.64641621
85Linoleic acid metabolism_Homo sapiens_hsa005910.64522394
86Dorso-ventral axis formation_Homo sapiens_hsa043200.63985055
87mTOR signaling pathway_Homo sapiens_hsa041500.63037479
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.62106835
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.59810996
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58635927
91Alcoholism_Homo sapiens_hsa050340.58193118
92Insulin resistance_Homo sapiens_hsa049310.56544479
93Prolactin signaling pathway_Homo sapiens_hsa049170.55069196
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54434919
95Ovarian steroidogenesis_Homo sapiens_hsa049130.53256514
96Insulin signaling pathway_Homo sapiens_hsa049100.52890641
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52585091
98ErbB signaling pathway_Homo sapiens_hsa040120.52572204
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52466105
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52286984
101Metabolic pathways_Homo sapiens_hsa011000.51566796
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51436548
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51411277
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50687515
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50681017
106Inositol phosphate metabolism_Homo sapiens_hsa005620.50287742
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49768881
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49130354
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48157680
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.48124357
111Regulation of autophagy_Homo sapiens_hsa041400.46955498
112Glutathione metabolism_Homo sapiens_hsa004800.45288198
113Retinol metabolism_Homo sapiens_hsa008300.44190987
114Cardiac muscle contraction_Homo sapiens_hsa042600.43215359
115Fatty acid degradation_Homo sapiens_hsa000710.41456020
116Histidine metabolism_Homo sapiens_hsa003400.41123815
117Galactose metabolism_Homo sapiens_hsa000520.39220275
118MAPK signaling pathway_Homo sapiens_hsa040100.39089760
119Oocyte meiosis_Homo sapiens_hsa041140.38331508
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36901463
121Dilated cardiomyopathy_Homo sapiens_hsa054140.36874491
122Bile secretion_Homo sapiens_hsa049760.36745027
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35434044
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.35416106
125Alzheimers disease_Homo sapiens_hsa050100.31510257
126Choline metabolism in cancer_Homo sapiens_hsa052310.26982965
127Ras signaling pathway_Homo sapiens_hsa040140.26973872
128ABC transporters_Homo sapiens_hsa020100.25088724
129AMPK signaling pathway_Homo sapiens_hsa041520.24959378
130Endocytosis_Homo sapiens_hsa041440.24898397
131Renal cell carcinoma_Homo sapiens_hsa052110.23806048
132Butanoate metabolism_Homo sapiens_hsa006500.22575552
133Axon guidance_Homo sapiens_hsa043600.22107650
134Endometrial cancer_Homo sapiens_hsa052130.20322144
135Sphingolipid metabolism_Homo sapiens_hsa006000.17230887
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17151300

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