CHI3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.40435804
2positive regulation of cellular amide metabolic process (GO:0034250)5.05364103
3endothelial cell chemotaxis (GO:0035767)4.91502396
4T-helper 1 type immune response (GO:0042088)4.75312517
5regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.58589995
6regulation of superoxide anion generation (GO:0032928)4.52703761
7* amino sugar catabolic process (GO:0046348)4.50627120
8positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.47631556
9negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.38184662
10surfactant homeostasis (GO:0043129)4.33963240
11positive regulation of p38MAPK cascade (GO:1900745)4.21898877
12glycosphingolipid catabolic process (GO:0046479)4.17557854
13regulation of phospholipase A2 activity (GO:0032429)4.10091785
14macrophage differentiation (GO:0030225)3.89384406
15venous blood vessel morphogenesis (GO:0048845)3.84709890
16coronary vasculature morphogenesis (GO:0060977)3.80928180
17regulation of beta-amyloid formation (GO:1902003)3.78963006
18positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.73807190
19positive regulation of bone resorption (GO:0045780)3.73651724
20positive regulation of bone remodeling (GO:0046852)3.73651724
21cellular response to thyroid hormone stimulus (GO:0097067)3.73542191
22glycolipid catabolic process (GO:0019377)3.72638226
23detection of molecule of bacterial origin (GO:0032490)3.65991944
24oligosaccharide catabolic process (GO:0009313)3.54209895
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45285452
26regulation of endothelial cell chemotaxis (GO:2001026)3.43118762
27detection of external biotic stimulus (GO:0098581)3.41049797
28positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.38476611
29regulation of cholesterol storage (GO:0010885)3.38266581
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36183197
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35972241
32detection of other organism (GO:0098543)3.33878688
33* glucosamine-containing compound catabolic process (GO:1901072)3.33087662
34positive regulation of protein kinase C signaling (GO:0090037)3.29873645
35ceramide catabolic process (GO:0046514)3.29772684
36regulation of amyloid precursor protein catabolic process (GO:1902991)3.28186136
37antigen processing and presentation of endogenous antigen (GO:0019883)3.20231559
38vascular endothelial growth factor signaling pathway (GO:0038084)3.19219904
39macrophage activation involved in immune response (GO:0002281)3.16784584
40detection of bacterium (GO:0016045)3.13207145
41negative regulation of bone resorption (GO:0045779)3.12930761
42response to thyroid hormone (GO:0097066)3.09068610
43chemical homeostasis within a tissue (GO:0048875)3.08811075
44response to peptidoglycan (GO:0032494)3.08005187
45detection of biotic stimulus (GO:0009595)3.03959647
46microglial cell activation (GO:0001774)3.01376207
47regulation of p38MAPK cascade (GO:1900744)3.01267432
48barbed-end actin filament capping (GO:0051016)2.97589225
49positive regulation of cholesterol efflux (GO:0010875)2.94488304
50regulation of superoxide metabolic process (GO:0090322)2.94429480
51positive regulation of vascular permeability (GO:0043117)2.89471596
52negative regulation of cell killing (GO:0031342)2.89213482
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89213482
54macrophage activation (GO:0042116)2.88253994
55neutrophil activation involved in immune response (GO:0002283)2.87534592
56regulation of cholesterol esterification (GO:0010872)2.87193371
57cellular extravasation (GO:0045123)2.86816750
58regulation of cellular amide metabolic process (GO:0034248)2.86287860
59regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.85901047
60phospholipid efflux (GO:0033700)2.83433723
61regulation of bone resorption (GO:0045124)2.82377047
62granulocyte chemotaxis (GO:0071621)2.77626430
63negative regulation of tissue remodeling (GO:0034104)2.77071467
64apoptotic cell clearance (GO:0043277)2.73156882
65positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72072248
66adenosine receptor signaling pathway (GO:0001973)2.70741406
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69291921
68positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.68690389
69granulocyte migration (GO:0097530)2.67421078
70positive regulation of histone deacetylation (GO:0031065)2.65579473
71positive regulation of macrophage cytokine production (GO:0060907)2.65495689
72mannose metabolic process (GO:0006013)2.64168163
73positive regulation of axon extension (GO:0045773)2.63834751
74immunoglobulin mediated immune response (GO:0016064)2.62315160
75positive regulation of extracellular matrix organization (GO:1903055)2.53789143
76peptide catabolic process (GO:0043171)2.53337111
77astrocyte differentiation (GO:0048708)2.52780862
78phagosome maturation (GO:0090382)2.52188800
79fat-soluble vitamin biosynthetic process (GO:0042362)2.52154031
80positive regulation of sterol transport (GO:0032373)2.50440166
81positive regulation of cholesterol transport (GO:0032376)2.50440166
82lung vasculature development (GO:0060426)2.49895914
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49318433
84membrane lipid catabolic process (GO:0046466)2.48939061
85negative regulation of interleukin-12 production (GO:0032695)2.48537410
86sphingolipid catabolic process (GO:0030149)2.48307124
87regulation of macrophage cytokine production (GO:0010935)2.45466255
88regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.45459938
89positive regulation of tissue remodeling (GO:0034105)2.45300909
90positive regulation of antigen processing and presentation (GO:0002579)2.45024839
91protein localization to endosome (GO:0036010)2.44391339
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.44249829
93complement activation, classical pathway (GO:0006958)2.42591587
94interferon-gamma-mediated signaling pathway (GO:0060333)2.41976731
95eosinophil chemotaxis (GO:0048245)2.41959654
96positive regulation by symbiont of host defense response (GO:0052509)2.41401920
97modulation by symbiont of host defense response (GO:0052031)2.41401920
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41401920
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.41401920
100modulation by symbiont of host immune response (GO:0052553)2.41401920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.79130164
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.70173868
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.69157511
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.18388386
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.85935355
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60322015
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44719444
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42228450
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32011560
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29524347
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26645329
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26000680
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18427588
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12878614
15* LXR_22292898_ChIP-Seq_THP-1_Human2.03526323
16VDR_24787735_ChIP-Seq_THP-1_Human2.03210603
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98175809
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.90691063
19SPI1_23127762_ChIP-Seq_K562_Human1.82112704
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78513972
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76405556
22VDR_21846776_ChIP-Seq_THP-1_Human1.72516152
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72091123
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71759877
25VDR_24763502_ChIP-Seq_THP-1_Human1.69959081
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69944867
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.68921272
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67119715
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62768978
30CLOCK_20551151_ChIP-Seq_293T_Human1.60893502
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56637662
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49879440
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46419041
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.43983441
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38521484
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.36754807
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.36648909
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36612170
39KDM2B_26808549_Chip-Seq_K562_Human1.29152501
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.28708706
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28376310
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27645633
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26250177
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.24203488
45KDM2B_26808549_Chip-Seq_DND41_Human1.21584542
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20375422
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19308890
48TCF7_22412390_ChIP-Seq_EML_Mouse1.17388355
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16574059
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16230487
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.14959726
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13172674
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13012857
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12567939
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.12499998
56EGR1_19032775_ChIP-ChIP_M12_Human1.12045592
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11888646
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11301274
59SCL_19346495_ChIP-Seq_HPC-7_Human1.10832265
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09021163
61SPI1_23547873_ChIP-Seq_NB4_Human1.08022809
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06483774
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06170681
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05233619
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04579767
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03936863
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02968759
68RXR_22158963_ChIP-Seq_LIVER_Mouse0.99796726
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99032129
70* PU_27001747_Chip-Seq_BMDM_Mouse0.98932419
71RUNX_20019798_ChIP-Seq_JUKART_Human0.94880855
72PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94777968
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94507437
74TP63_17297297_ChIP-ChIP_HaCaT_Human0.94191801
75RACK7_27058665_Chip-Seq_MCF-7_Human0.93556478
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93306749
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93251506
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90883087
79ERG_21242973_ChIP-ChIP_JURKAT_Human0.89363914
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89335065
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88878043
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.88600524
83TBX20_22080862_ChIP-Seq_HEART_Mouse0.88350817
84TBX20_22328084_ChIP-Seq_HEART_Mouse0.88350817
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88172696
86GATA1_19941826_ChIP-Seq_K562_Human0.87758711
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87444542
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87354152
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87172745
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85872218
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85839372
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85587165
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83514605
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83006262
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81393973
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81333022
97MAF_26560356_Chip-Seq_TH1_Human0.78846684
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77371142
99ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76684604
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76058066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.24665853
2MP0005058_abnormal_lysosome_morphology3.76137668
3MP0000604_amyloidosis3.69967127
4MP0003329_amyloid_beta_deposits3.40752583
5MP0009840_abnormal_foam_cell3.33045477
6MP0003191_abnormal_cellular_cholesterol3.25222341
7MP0003303_peritoneal_inflammation3.00395119
8MP0003172_abnormal_lysosome_physiology2.85535681
9MP0006082_CNS_inflammation2.82059490
10MP0003724_increased_susceptibility_to2.77314177
11MP0003436_decreased_susceptibility_to2.65961210
12MP0003690_abnormal_glial_cell2.59506282
13MP0009278_abnormal_bone_marrow2.45199613
14MP0000343_altered_response_to2.29334138
15MP0005167_abnormal_blood-brain_barrier2.29125761
16MP0001853_heart_inflammation2.22778414
17* MP0002419_abnormal_innate_immunity2.21566802
18MP0003300_gastrointestinal_ulcer2.16714289
19MP0003075_altered_response_to2.13394763
20MP0002148_abnormal_hypersensitivity_rea2.08703565
21MP0009785_altered_susceptibility_to2.02557037
22MP0001835_abnormal_antigen_presentation1.98422680
23MP0002998_abnormal_bone_remodeling1.82136672
24MP0001790_abnormal_immune_system1.81073978
25MP0005387_immune_system_phenotype1.81073978
26MP0001533_abnormal_skeleton_physiology1.79109626
27MP0003195_calcinosis1.77983624
28MP0005025_abnormal_response_to1.76933664
29MP0009384_cardiac_valve_regurgitation1.72542686
30MP0003279_aneurysm1.72159222
31MP0003091_abnormal_cell_migration1.70491460
32MP0000920_abnormal_myelination1.61970357
33MP0000678_abnormal_parathyroid_gland1.61938584
34MP0000685_abnormal_immune_system1.57309005
35MP0005000_abnormal_immune_tolerance1.56829136
36MP0003705_abnormal_hypodermis_morpholog1.49627040
37MP0005397_hematopoietic_system_phenotyp1.49014919
38MP0001545_abnormal_hematopoietic_system1.49014919
39MP0005671_abnormal_response_to1.48113208
40MP0008775_abnormal_heart_ventricle1.45569186
41MP0008260_abnormal_autophagy1.41637421
42MP0001958_emphysema1.38456006
43* MP0002452_abnormal_antigen_presenting1.36561431
44MP0003634_abnormal_glial_cell1.35693459
45MP0009764_decreased_sensitivity_to1.33543519
46MP0005166_decreased_susceptibility_to1.30338288
47MP0004947_skin_inflammation1.27522815
48MP0005464_abnormal_platelet_physiology1.27444084
49MP0004883_abnormal_blood_vessel1.25281207
50* MP0002723_abnormal_immune_serum1.25251777
51MP0005164_abnormal_response_to1.24671405
52MP0004510_myositis1.24101344
53MP0005257_abnormal_intraocular_pressure1.21822345
54MP0005023_abnormal_wound_healing1.18800247
55MP0001845_abnormal_inflammatory_respons1.10953798
56MP0008469_abnormal_protein_level1.10458078
57MP0003453_abnormal_keratinocyte_physiol1.10044701
58* MP0001800_abnormal_humoral_immune1.09502446
59MP0002877_abnormal_melanocyte_morpholog1.09323678
60MP0003448_altered_tumor_morphology1.09283803
61MP0005451_abnormal_body_composition1.07329840
62MP0001849_ear_inflammation1.06167832
63MP0005365_abnormal_bile_salt1.05878257
64MP0000747_muscle_weakness1.04916839
65* MP0002420_abnormal_adaptive_immunity1.01166126
66* MP0001819_abnormal_immune_cell1.00263915
67MP0002405_respiratory_system_inflammati0.96955571
68MP0000249_abnormal_blood_vessel0.96826924
69MP0002139_abnormal_hepatobiliary_system0.94862238
70MP0004233_abnormal_muscle_weight0.94446875
71MP0003632_abnormal_nervous_system0.94232927
72MP0005165_increased_susceptibility_to0.93908943
73MP0003828_pulmonary_edema0.93310334
74MP0003795_abnormal_bone_structure0.88606449
75MP0005595_abnormal_vascular_smooth0.88129731
76MP0002254_reproductive_system_inflammat0.86544337
77MP0005388_respiratory_system_phenotype0.86529627
78MP0002133_abnormal_respiratory_system0.86529627
79MP0005390_skeleton_phenotype0.83465887
80MP0002933_joint_inflammation0.83278407
81MP0000383_abnormal_hair_follicle0.81189986
82MP0003045_fibrosis0.79043979
83MP0001879_abnormal_lymphatic_vessel0.78380017
84MP0010155_abnormal_intestine_physiology0.78282564
85MP0003633_abnormal_nervous_system0.77803350
86MP0004858_abnormal_nervous_system0.76996190
87MP0008438_abnormal_cutaneous_collagen0.76508870
88MP0002896_abnormal_bone_mineralization0.75676319
89MP0000579_abnormal_nail_morphology0.74103396
90MP0009763_increased_sensitivity_to0.70447122
91MP0004084_abnormal_cardiac_muscle0.70219753
92MP0002090_abnormal_vision0.69774214
93MP0003566_abnormal_cell_adhesion0.69272398
94MP0000858_altered_metastatic_potential0.69190638
95MP0005310_abnormal_salivary_gland0.67401478
96MP0001440_abnormal_grooming_behavior0.65898784
97MP0003631_nervous_system_phenotype0.65200022
98MP0003656_abnormal_erythrocyte_physiolo0.64964030
99MP0008874_decreased_physiological_sensi0.63950262
100* MP0009333_abnormal_splenocyte_physiolog0.63012863

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.40014649
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.40014649
3Abnormality of glycolipid metabolism (HP:0010969)7.40014649
4Systemic lupus erythematosus (HP:0002725)5.99065004
5Increased cerebral lipofuscin (HP:0011813)4.96746599
6Neurofibrillary tangles (HP:0002185)4.45267060
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.10373881
8Glomerulonephritis (HP:0000099)4.10231153
9Abnormality of macrophages (HP:0004311)3.98567316
10Dysostosis multiplex (HP:0000943)3.92977155
11Vacuolated lymphocytes (HP:0001922)3.91852177
12Loss of speech (HP:0002371)3.89868673
13Eczematoid dermatitis (HP:0000976)3.77604512
14Complement deficiency (HP:0004431)3.76257933
15Axonal loss (HP:0003447)3.62035954
16Myocardial infarction (HP:0001658)3.52320383
17Disinhibition (HP:0000734)3.29425334
18Recurrent gram-negative bacterial infections (HP:0005420)3.26360245
19Cerebral inclusion bodies (HP:0100314)3.21262559
20Recurrent abscess formation (HP:0002722)3.20756317
21Abnormality of complement system (HP:0005339)3.14781972
22Recurrent bacterial skin infections (HP:0005406)3.14621873
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04567568
24Abnormality of polysaccharide metabolism (HP:0011012)3.04567568
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04567568
26Mucopolysacchariduria (HP:0008155)2.97543284
27Urinary glycosaminoglycan excretion (HP:0003541)2.97543284
28Purpura (HP:0000979)2.87330354
29Orchitis (HP:0100796)2.85889664
30Mutism (HP:0002300)2.74655375
31Myositis (HP:0100614)2.68980008
32Amyloidosis (HP:0011034)2.63942701
33Upper motor neuron abnormality (HP:0002127)2.54066209
34Mediastinal lymphadenopathy (HP:0100721)2.53556535
35Xanthomatosis (HP:0000991)2.53044326
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52830881
37Cerebral aneurysm (HP:0004944)2.51642789
38Increased CSF protein (HP:0002922)2.51633761
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50203656
40Apathy (HP:0000741)2.49983819
41Turricephaly (HP:0000262)2.46154416
42Diminished motivation (HP:0000745)2.45619871
43Retrobulbar optic neuritis (HP:0100654)2.45457893
44Optic neuritis (HP:0100653)2.45457893
45Nephritis (HP:0000123)2.44516583
46Vertebral compression fractures (HP:0002953)2.37635361
47Neuronal loss in central nervous system (HP:0002529)2.34480103
48Hyperacusis (HP:0010780)2.26829486
49Obstructive sleep apnea (HP:0002870)2.25544530
50Hepatosplenomegaly (HP:0001433)2.23690824
51Nuclear cataract (HP:0100018)2.22872969
52Dementia (HP:0000726)2.21475025
53Segmental peripheral demyelination/remyelination (HP:0003481)2.13019704
54Interstitial pulmonary disease (HP:0006530)2.12811752
55Basal ganglia calcification (HP:0002135)2.12413614
56Autoimmune thrombocytopenia (HP:0001973)2.11779177
57Gingivitis (HP:0000230)2.11003901
58Supranuclear gaze palsy (HP:0000605)2.08643866
59Abnormality of the periventricular white matter (HP:0002518)2.08071340
60Pathologic fracture (HP:0002756)2.03551889
61Increased variability in muscle fiber diameter (HP:0003557)2.03505119
62Chronic obstructive pulmonary disease (HP:0006510)2.01461730
63Obstructive lung disease (HP:0006536)2.01461730
64Cardiomegaly (HP:0001640)2.00897862
65Pulmonary infiltrates (HP:0002113)2.00420721
66Progressive neurologic deterioration (HP:0002344)1.99281104
67Recurrent skin infections (HP:0001581)1.99208183
68Bone pain (HP:0002653)1.98331747
69Peripheral demyelination (HP:0011096)1.95655635
70Skin nodule (HP:0200036)1.94327214
71J-shaped sella turcica (HP:0002680)1.93097589
72Agnosia (HP:0010524)1.90126562
73Protuberant abdomen (HP:0001538)1.86395077
74Asymmetric septal hypertrophy (HP:0001670)1.83812543
75Elfin facies (HP:0004428)1.83249145
76Thin bony cortex (HP:0002753)1.82384022
77Hemoptysis (HP:0002105)1.81915381
78Increased IgE level (HP:0003212)1.81741787
79Restrictive lung disease (HP:0002091)1.79319175
80Retinal atrophy (HP:0001105)1.77163809
81Abnormality of the endocardium (HP:0004306)1.73858227
82Abnormality of skeletal muscle fiber size (HP:0012084)1.72386130
83Poor head control (HP:0002421)1.72026516
84Alveolar cell carcinoma (HP:0006519)1.71584759
85Spontaneous hematomas (HP:0007420)1.69181993
86Gastrointestinal infarctions (HP:0005244)1.67389770
87Recurrent fungal infections (HP:0002841)1.67079146
88Overriding aorta (HP:0002623)1.66320041
89Insomnia (HP:0100785)1.65976928
90Prolonged neonatal jaundice (HP:0006579)1.65812140
91Increased serum ferritin (HP:0003281)1.64268103
92Neoplasm of the tracheobronchial system (HP:0100552)1.63467389
93Personality changes (HP:0000751)1.62548281
94Mesangial abnormality (HP:0001966)1.61967752
95Global brain atrophy (HP:0002283)1.61786867
96Keratoconjunctivitis sicca (HP:0001097)1.60616844
97Inappropriate behavior (HP:0000719)1.60363359
98Cellulitis (HP:0100658)1.60280558
99Renovascular hypertension (HP:0100817)1.59723465
100Pulmonary embolism (HP:0002204)1.58962192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB45.65930410
2BLK3.14646540
3ERN13.13916869
4TYK22.93281179
5TRIB32.72982202
6FGFR42.36432989
7IRAK32.35345884
8RIPK41.97217492
9RIPK11.92736147
10PKN11.91140082
11NEK91.79654683
12MAP3K31.70450141
13PDGFRA1.67765368
14JAK11.67195127
15CSK1.62865343
16ZAP701.61501169
17JAK21.60370273
18MAP3K131.56632266
19FES1.54681196
20EPHB11.53484071
21EPHA31.52922062
22DDR21.50713138
23MAPK111.46451256
24TYRO31.46214259
25KIT1.45095169
26TGFBR21.44592398
27TBK11.37962007
28MAPK151.34298842
29PRPF4B1.33596073
30ERBB21.31680113
31MAP3K141.28812001
32CDC42BPA1.27532577
33FGFR31.23600117
34IRAK41.10340882
35MAP2K31.10330399
36FGR1.10085519
37JAK31.08877333
38ABL21.08773214
39PDGFRB1.04612778
40KSR21.03455567
41MAP3K60.99947621
42NTRK10.94500849
43CAMK2G0.92257094
44PKN20.91626107
45PDPK10.91585014
46NTRK30.87854771
47ROCK20.87458382
48IKBKE0.86456482
49MAP3K10.85023691
50CSF1R0.84875444
51HCK0.82993076
52NEK60.82399151
53LIMK10.82251909
54LYN0.81200333
55MOS0.78497090
56RET0.76921598
57CAMKK20.76211176
58SYK0.73698882
59CAMKK10.72946954
60GRK70.70930863
61CAMK1D0.70434652
62TNK20.68513618
63MAPK120.68242928
64PRKD20.67683348
65MAP4K10.66904481
66IRAK10.66319943
67RPS6KA20.65693432
68LATS20.65619264
69MARK20.64077668
70PDK20.63385271
71MAPK70.63094781
72MAP3K110.62823604
73SIK10.61682195
74TAOK20.61344332
75TAOK10.61248627
76MAPK40.60435883
77PTK20.59282476
78NTRK20.57646731
79ABL10.56689131
80PRKD10.54725566
81TESK20.54277375
82FYN0.52571603
83LCK0.52434088
84TESK10.51862322
85PDK10.51590704
86PAK40.50180414
87SRC0.49022386
88NME20.44717676
89CAMK1G0.44126514
90BMX0.43659541
91ARAF0.43248740
92GSK3A0.42813590
93PTK60.42723222
94MATK0.42017537
95TTN0.41994105
96SMG10.40481354
97PRKCH0.40402202
98IKBKB0.39276374
99MAPKAPK20.38916703
100ROCK10.37915079

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.37836052
2Staphylococcus aureus infection_Homo sapiens_hsa051503.34129874
3Lysosome_Homo sapiens_hsa041423.17033109
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.51828012
5Rheumatoid arthritis_Homo sapiens_hsa053232.27061254
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19314700
7Osteoclast differentiation_Homo sapiens_hsa043802.18167870
8Leishmaniasis_Homo sapiens_hsa051402.17929679
9Phagosome_Homo sapiens_hsa041452.10313994
10Complement and coagulation cascades_Homo sapiens_hsa046101.88421481
11Tuberculosis_Homo sapiens_hsa051521.88376651
12Pertussis_Homo sapiens_hsa051331.75856206
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70151471
14Allograft rejection_Homo sapiens_hsa053301.69831396
15Malaria_Homo sapiens_hsa051441.65041447
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.64063975
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61091720
18Bladder cancer_Homo sapiens_hsa052191.59872878
19Vibrio cholerae infection_Homo sapiens_hsa051101.51584810
20Graft-versus-host disease_Homo sapiens_hsa053321.50914371
21Autoimmune thyroid disease_Homo sapiens_hsa053201.50425689
22Asthma_Homo sapiens_hsa053101.49252530
23Collecting duct acid secretion_Homo sapiens_hsa049661.46863241
24Antigen processing and presentation_Homo sapiens_hsa046121.45575273
25Dorso-ventral axis formation_Homo sapiens_hsa043201.40350125
26Prion diseases_Homo sapiens_hsa050201.39119253
27Toxoplasmosis_Homo sapiens_hsa051451.28143215
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24834544
29Pancreatic cancer_Homo sapiens_hsa052121.20595605
30Viral myocarditis_Homo sapiens_hsa054161.14684718
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14119059
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12652364
33Type I diabetes mellitus_Homo sapiens_hsa049401.11738584
34PPAR signaling pathway_Homo sapiens_hsa033201.11542149
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10094324
36TNF signaling pathway_Homo sapiens_hsa046681.04152857
37HIF-1 signaling pathway_Homo sapiens_hsa040661.03925006
38VEGF signaling pathway_Homo sapiens_hsa043701.02042343
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00074086
40Notch signaling pathway_Homo sapiens_hsa043300.99719993
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94946558
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.94608474
43Amoebiasis_Homo sapiens_hsa051460.94290762
44Influenza A_Homo sapiens_hsa051640.94181831
45Salmonella infection_Homo sapiens_hsa051320.93901651
46Renal cell carcinoma_Homo sapiens_hsa052110.93366608
47B cell receptor signaling pathway_Homo sapiens_hsa046620.91292332
48Hepatitis C_Homo sapiens_hsa051600.90501440
49Chemokine signaling pathway_Homo sapiens_hsa040620.88516732
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.87435951
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.86689504
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84191798
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.84050836
54Legionellosis_Homo sapiens_hsa051340.82823773
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81978871
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81792098
57Hematopoietic cell lineage_Homo sapiens_hsa046400.79033215
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78739462
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74491547
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74309028
61GnRH signaling pathway_Homo sapiens_hsa049120.73296163
62Estrogen signaling pathway_Homo sapiens_hsa049150.71615632
63Sphingolipid metabolism_Homo sapiens_hsa006000.71137076
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.69828836
65Non-small cell lung cancer_Homo sapiens_hsa052230.66164361
66Mineral absorption_Homo sapiens_hsa049780.66145264
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65275018
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.63996249
69mTOR signaling pathway_Homo sapiens_hsa041500.63610705
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63602353
71Rap1 signaling pathway_Homo sapiens_hsa040150.62207359
72Glioma_Homo sapiens_hsa052140.61929856
73Focal adhesion_Homo sapiens_hsa045100.60425414
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.59250073
75Acute myeloid leukemia_Homo sapiens_hsa052210.59001718
76Herpes simplex infection_Homo sapiens_hsa051680.58695208
77Galactose metabolism_Homo sapiens_hsa000520.58475661
78Measles_Homo sapiens_hsa051620.58105148
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.57993294
80Bile secretion_Homo sapiens_hsa049760.56800750
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55605868
82Endocytosis_Homo sapiens_hsa041440.54204291
83Endometrial cancer_Homo sapiens_hsa052130.51877318
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.49752184
85African trypanosomiasis_Homo sapiens_hsa051430.48689330
86Choline metabolism in cancer_Homo sapiens_hsa052310.48220053
87Proteoglycans in cancer_Homo sapiens_hsa052050.44388443
88Synaptic vesicle cycle_Homo sapiens_hsa047210.44085875
89Platelet activation_Homo sapiens_hsa046110.43631975
90Apoptosis_Homo sapiens_hsa042100.43502263
91Ras signaling pathway_Homo sapiens_hsa040140.42635908
92Fructose and mannose metabolism_Homo sapiens_hsa000510.41087694
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40783423
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.39931090
95Prolactin signaling pathway_Homo sapiens_hsa049170.39884132
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39760088
97ECM-receptor interaction_Homo sapiens_hsa045120.38318315
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37957959
99ErbB signaling pathway_Homo sapiens_hsa040120.35122732
100Hepatitis B_Homo sapiens_hsa051610.33870506

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