CHI3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.30245542
2T cell migration (GO:0072678)5.95185079
3positive regulation of gamma-delta T cell activation (GO:0046645)5.76116415
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.62660433
5negative thymic T cell selection (GO:0045060)5.61241820
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59697351
7antigen processing and presentation of endogenous antigen (GO:0019883)5.59105508
8negative T cell selection (GO:0043383)5.56725914
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.32100806
10B cell receptor signaling pathway (GO:0050853)5.20655819
11immunoglobulin mediated immune response (GO:0016064)5.20381544
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.96269744
13cellular response to type I interferon (GO:0071357)4.85493280
14type I interferon signaling pathway (GO:0060337)4.85493280
15response to type I interferon (GO:0034340)4.83758967
16positive thymic T cell selection (GO:0045059)4.81053631
17interferon-gamma-mediated signaling pathway (GO:0060333)4.79659753
18B cell mediated immunity (GO:0019724)4.68077656
19thymic T cell selection (GO:0045061)4.64375951
20T-helper 1 type immune response (GO:0042088)4.63937821
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51604646
22regulation of alpha-beta T cell proliferation (GO:0046640)4.41831417
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36739726
24regulation of gamma-delta T cell activation (GO:0046643)4.27393877
25positive regulation by symbiont of host defense response (GO:0052509)4.26285800
26modulation by symbiont of host defense response (GO:0052031)4.26285800
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26285800
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26285800
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.26285800
30modulation by symbiont of host immune response (GO:0052553)4.26285800
31positive regulation of alpha-beta T cell proliferation (GO:0046641)4.20111982
32positive T cell selection (GO:0043368)4.20034514
33B cell proliferation (GO:0042100)4.18112621
34negative regulation of cell killing (GO:0031342)4.15908176
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15908176
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.15283349
37positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.14597604
38regulation of antigen processing and presentation (GO:0002577)4.07411893
39T cell selection (GO:0045058)4.06476387
40detection of bacterium (GO:0016045)4.01494487
41positive regulation of B cell differentiation (GO:0045579)3.94432626
42T cell costimulation (GO:0031295)3.82604467
43myeloid dendritic cell differentiation (GO:0043011)3.81856376
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81257849
45lymphocyte costimulation (GO:0031294)3.76924480
46B cell homeostasis (GO:0001782)3.75739704
47cellular response to interferon-gamma (GO:0071346)3.74765333
48detection of other organism (GO:0098543)3.72374796
49positive regulation of humoral immune response (GO:0002922)3.71128931
50cellular response to interleukin-15 (GO:0071350)3.66898513
51myeloid dendritic cell activation (GO:0001773)3.66167173
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62247275
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58765430
54regulation of gamma-delta T cell differentiation (GO:0045586)3.57883858
55response to interleukin-15 (GO:0070672)3.56484656
56regulation of interferon-gamma biosynthetic process (GO:0045072)3.53560445
57positive regulation of interferon-alpha production (GO:0032727)3.45869094
58positive regulation of antigen processing and presentation (GO:0002579)3.44870128
59NIK/NF-kappaB signaling (GO:0038061)3.43310810
60regulation of interleukin-2 biosynthetic process (GO:0045076)3.39817137
61regulation of interferon-alpha production (GO:0032647)3.38063964
62antigen receptor-mediated signaling pathway (GO:0050851)3.34287041
63response to interferon-gamma (GO:0034341)3.33252322
64lymphocyte migration (GO:0072676)3.29768578
65regulation of B cell differentiation (GO:0045577)3.29689961
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28994702
67adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.27337597
68positive regulation of macrophage cytokine production (GO:0060907)3.26728468
69regulation of interferon-beta biosynthetic process (GO:0045357)3.25580381
70response to host immune response (GO:0052572)3.23225498
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23225498
72positive regulation of interleukin-2 production (GO:0032743)3.21716505
73regulation of B cell proliferation (GO:0030888)3.21605539
74cytidine metabolic process (GO:0046087)3.16563261
75cytidine catabolic process (GO:0006216)3.16563261
76cytidine deamination (GO:0009972)3.16563261
77leukocyte aggregation (GO:0070486)3.15980500
78positive regulation of B cell mediated immunity (GO:0002714)3.11603747
79positive regulation of immunoglobulin mediated immune response (GO:0002891)3.11603747
80detection of external biotic stimulus (GO:0098581)3.08325784
81positive regulation of B cell proliferation (GO:0030890)3.04306780
82regulation of T-helper 1 cell differentiation (GO:0045625)2.99434760
83negative regulation of B cell proliferation (GO:0030889)2.99286436
84macrophage activation involved in immune response (GO:0002281)2.98243501
85T cell lineage commitment (GO:0002360)2.98056564
86response to muramyl dipeptide (GO:0032495)2.97748986
87negative regulation of viral genome replication (GO:0045071)2.97352692
88regulation of inositol phosphate biosynthetic process (GO:0010919)2.97144481
89regulation of alpha-beta T cell activation (GO:0046634)2.96588478
90positive regulation of defense response to virus by host (GO:0002230)2.95626362
91mast cell activation (GO:0045576)2.93612480
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.93444845
93mature B cell differentiation (GO:0002335)2.92739147
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91973847
95positive regulation of protein homooligomerization (GO:0032464)2.91660383
96regulation of T cell mediated cytotoxicity (GO:0001914)2.91030463
97production of molecular mediator of immune response (GO:0002440)2.90684934
98lymphocyte homeostasis (GO:0002260)2.89808797
99positive regulation of B cell activation (GO:0050871)2.89230201
100response to interferon-beta (GO:0035456)2.89086852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.34455064
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.86297412
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.55251324
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.18070822
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.15727290
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88271105
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.82344634
8MYC_22102868_ChIP-Seq_BL_Human3.61100033
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51085110
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87684702
11MYB_26560356_Chip-Seq_TH2_Human2.83520535
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.83460376
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83339595
14VDR_21846776_ChIP-Seq_THP-1_Human2.72234174
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.69656351
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.63966884
17MAF_26560356_Chip-Seq_TH1_Human2.61821552
18* RUNX_20019798_ChIP-Seq_JUKART_Human2.46918375
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.45726997
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36290836
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35322816
22* MYB_26560356_Chip-Seq_TH1_Human2.34434578
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34014293
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.32446927
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15280154
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14715563
27E2F7_22180533_ChIP-Seq_HELA_Human2.10731790
28* UTX_26944678_Chip-Seq_JUKART_Human2.06985103
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02366627
30CIITA_25753668_ChIP-Seq_RAJI_Human2.00670783
31VDR_24763502_ChIP-Seq_THP-1_Human1.97448944
32GATA3_27048872_Chip-Seq_THYMUS_Human1.92426745
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91056974
34SPI1_23547873_ChIP-Seq_NB4_Human1.90580719
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88500381
36MAF_26560356_Chip-Seq_TH2_Human1.87429524
37* NOTCH1_21737748_ChIP-Seq_TLL_Human1.87138457
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85579904
39SCL_19346495_ChIP-Seq_HPC-7_Human1.84117792
40GATA1_22025678_ChIP-Seq_K562_Human1.83616892
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79449204
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72782463
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61997189
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60716470
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58659550
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55164672
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53852949
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.39582923
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37719620
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37312324
51GATA3_26560356_Chip-Seq_TH2_Human1.36694209
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34056405
53SPI1_23127762_ChIP-Seq_K562_Human1.32847807
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28581082
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25238161
56LXR_22292898_ChIP-Seq_THP-1_Human1.22581253
57TCF7_22412390_ChIP-Seq_EML_Mouse1.20932672
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20192645
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.18074648
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15536490
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15330887
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12479719
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09132771
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09021337
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07910548
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07042029
67VDR_24787735_ChIP-Seq_THP-1_Human1.06975932
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03442161
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02608941
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01951964
71BCOR_27268052_Chip-Seq_Bcells_Human1.01739002
72BCL6_27268052_Chip-Seq_Bcells_Human0.99874962
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99732414
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99564366
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98050118
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.97184766
77E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95784231
78P300_27268052_Chip-Seq_Bcells_Human0.94098927
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91232986
80KDM2B_26808549_Chip-Seq_DND41_Human0.91081948
81* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89200103
82PU_27001747_Chip-Seq_BMDM_Mouse0.88770698
83STAT1_20625510_ChIP-Seq_HELA_Human0.88598378
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87155643
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86680355
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86390814
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.84956892
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83583824
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83215992
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82803418
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82080989
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81983927
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81651163
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80604093
95SMRT_27268052_Chip-Seq_Bcells_Human0.79767035
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79566100
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78401537
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76878091
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.76505002
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76078916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system5.19053826
2MP0005671_abnormal_response_to4.62909170
3MP0005387_immune_system_phenotype3.98916600
4MP0001790_abnormal_immune_system3.98916600
5MP0001835_abnormal_antigen_presentation3.96372117
6MP0001800_abnormal_humoral_immune3.69234479
7MP0003763_abnormal_thymus_physiology3.61711268
8MP0005000_abnormal_immune_tolerance3.37450094
9MP0003303_peritoneal_inflammation2.93371982
10MP0009785_altered_susceptibility_to2.87130011
11MP0002452_abnormal_antigen_presenting2.86863804
12MP0002723_abnormal_immune_serum2.85365573
13MP0002148_abnormal_hypersensitivity_rea2.67655538
14MP0002420_abnormal_adaptive_immunity2.66463965
15MP0001819_abnormal_immune_cell2.60597312
16MP0005025_abnormal_response_to2.59597468
17MP0002166_altered_tumor_susceptibility2.49094497
18MP0003436_decreased_susceptibility_to2.40754581
19MP0003300_gastrointestinal_ulcer2.31156307
20MP0002398_abnormal_bone_marrow2.30756818
21MP0003724_increased_susceptibility_to2.26994921
22MP0009333_abnormal_splenocyte_physiolog2.26781180
23MP0000716_abnormal_immune_system2.17559758
24MP0005645_abnormal_hypothalamus_physiol2.15929979
25MP0002419_abnormal_innate_immunity2.09502031
26MP0006082_CNS_inflammation2.08284031
27MP0002006_tumorigenesis1.93358138
28MP0010155_abnormal_intestine_physiology1.88277973
29MP0003183_abnormal_peptide_metabolism1.81744222
30MP0001348_abnormal_lacrimal_gland1.80035739
31MP0003045_fibrosis1.75877866
32MP0002429_abnormal_blood_cell1.74902979
33MP0005310_abnormal_salivary_gland1.72932829
34MP0001845_abnormal_inflammatory_respons1.72775862
35MP0004947_skin_inflammation1.71175592
36MP0000689_abnormal_spleen_morphology1.70747098
37MP0002163_abnormal_gland_morphology1.66899660
38MP0002405_respiratory_system_inflammati1.66598173
39MP0002722_abnormal_immune_system1.66195258
40MP0002138_abnormal_hepatobiliary_system1.62401691
41MP0000703_abnormal_thymus_morphology1.56553637
42MP0004381_abnormal_hair_follicle1.38708352
43MP0002396_abnormal_hematopoietic_system1.36557313
44MP0005464_abnormal_platelet_physiology1.27130075
45MP0001853_heart_inflammation1.23391693
46MP0005379_endocrine/exocrine_gland_phen1.22627421
47MP0008469_abnormal_protein_level1.19965872
48MP0009764_decreased_sensitivity_to1.14852199
49MP0005166_decreased_susceptibility_to1.11593574
50MP0003866_abnormal_defecation1.09412559
51MP0003075_altered_response_to1.09183720
52MP0005451_abnormal_body_composition1.07248360
53MP0001533_abnormal_skeleton_physiology1.02842895
54MP0000858_altered_metastatic_potential0.94903314
55MP0002933_joint_inflammation0.92974738
56MP0005670_abnormal_white_adipose0.89938629
57MP0002019_abnormal_tumor_incidence0.85751249
58MP0009278_abnormal_bone_marrow0.85274983
59MP0003091_abnormal_cell_migration0.83642782
60MP0009840_abnormal_foam_cell0.82541945
61MP0004510_myositis0.81712182
62MP0008057_abnormal_DNA_replication0.81141808
63MP0009115_abnormal_fat_cell0.80930560
64MP0005075_abnormal_melanosome_morpholog0.80065543
65MP0001873_stomach_inflammation0.78388419
66MP0005397_hematopoietic_system_phenotyp0.77898553
67MP0001545_abnormal_hematopoietic_system0.77898553
68MP0009763_increased_sensitivity_to0.77797887
69MP0005167_abnormal_blood-brain_barrier0.76875509
70MP0001727_abnormal_embryo_implantation0.76273498
71MP0000920_abnormal_myelination0.73699319
72MP0000249_abnormal_blood_vessel0.71815013
73MP0003448_altered_tumor_morphology0.70616380
74MP0002136_abnormal_kidney_physiology0.68914295
75MP0003690_abnormal_glial_cell0.66189355
76MP0001851_eye_inflammation0.64228015
77MP0008874_decreased_physiological_sensi0.64178431
78MP0001346_abnormal_lacrimal_gland0.63889066
79MP0002998_abnormal_bone_remodeling0.62182026
80MP0004808_abnormal_hematopoietic_stem0.61787889
81MP0000604_amyloidosis0.61054235
82MP0000343_altered_response_to0.60502050
83MP0000371_diluted_coat_color0.60038158
84MP0002877_abnormal_melanocyte_morpholog0.58273866
85MP0008260_abnormal_autophagy0.57549120
86MP0002254_reproductive_system_inflammat0.54238880
87MP0000609_abnormal_liver_physiology0.51864389
88MP0002009_preneoplasia0.50853005
89MP0002693_abnormal_pancreas_physiology0.50541396
90MP0005666_abnormal_adipose_tissue0.49716238
91MP0000313_abnormal_cell_death0.48001896
92MP0010094_abnormal_chromosome_stability0.47831805
93MP0005584_abnormal_enzyme/coenzyme_acti0.47073286
94MP0008872_abnormal_physiological_respon0.46846411
95MP0009643_abnormal_urine_homeostasis0.46733258
96MP0003646_muscle_fatigue0.46643239
97MP0002970_abnormal_white_adipose0.46577642
98MP0005165_increased_susceptibility_to0.40456204
99MP0003950_abnormal_plasma_membrane0.40322050
100MP0000015_abnormal_ear_pigmentation0.39428834

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.52868369
2Agammaglobulinemia (HP:0004432)5.98714274
3Recurrent bronchitis (HP:0002837)5.30865717
4Lymphopenia (HP:0001888)5.27202669
5Abnormality of cells of the lymphoid lineage (HP:0012140)5.19896166
6Recurrent sinusitis (HP:0011108)5.02575410
7Vasculitis (HP:0002633)4.93706760
8IgA deficiency (HP:0002720)4.91283892
9Meningitis (HP:0001287)4.72414829
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.68610450
11Emphysema (HP:0002097)4.40228170
12IgM deficiency (HP:0002850)4.36558043
13Autoimmune hemolytic anemia (HP:0001890)4.17830752
14Recurrent viral infections (HP:0004429)4.17775569
15Increased IgE level (HP:0003212)4.14639116
16Increased IgM level (HP:0003496)4.05238966
17Eczematoid dermatitis (HP:0000976)4.01519500
18Panhypogammaglobulinemia (HP:0003139)3.91964977
19IgG deficiency (HP:0004315)3.91457240
20Mediastinal lymphadenopathy (HP:0100721)3.88965238
21Cellulitis (HP:0100658)3.87600831
22B lymphocytopenia (HP:0010976)3.81700495
23Abnormality of B cell number (HP:0010975)3.53522692
24Chronic diarrhea (HP:0002028)3.52926644
25Colitis (HP:0002583)3.51094438
26Abnormality of T cell physiology (HP:0011840)3.49963880
27Recurrent fungal infections (HP:0002841)3.49777155
28Restrictive lung disease (HP:0002091)3.46894933
29Recurrent pneumonia (HP:0006532)3.45872727
30Autoimmune thrombocytopenia (HP:0001973)3.39807254
31Verrucae (HP:0200043)3.39604977
32Papilloma (HP:0012740)3.39604977
33Recurrent lower respiratory tract infections (HP:0002783)3.30136715
34Recurrent bacterial skin infections (HP:0005406)3.27046055
35Abnormality of T cells (HP:0002843)3.25138229
36Recurrent cutaneous fungal infections (HP:0011370)3.17974875
37Chronic mucocutaneous candidiasis (HP:0002728)3.17974875
38Pulmonary infiltrates (HP:0002113)3.15782172
39Hypergammaglobulinemia (HP:0010702)3.15134683
40Lymphoma (HP:0002665)3.10641898
41Optic neuritis (HP:0100653)3.07721292
42Retrobulbar optic neuritis (HP:0100654)3.07721292
43Abnormality of T cell number (HP:0011839)3.06898389
44Urticaria (HP:0001025)3.04562178
45Inflammation of the large intestine (HP:0002037)3.00454046
46Granulocytopenia (HP:0001913)2.95856851
47Abnormality of macrophages (HP:0004311)2.93632406
48Gastrointestinal inflammation (HP:0004386)2.91349731
49Recurrent abscess formation (HP:0002722)2.90849059
50Severe combined immunodeficiency (HP:0004430)2.88626584
51Encephalitis (HP:0002383)2.84870405
52Orchitis (HP:0100796)2.84360710
53Bronchitis (HP:0012387)2.82853984
54Leukopenia (HP:0001882)2.82771679
55Osteomyelitis (HP:0002754)2.82511093
56Elevated erythrocyte sedimentation rate (HP:0003565)2.75237939
57Eosinophilia (HP:0001880)2.74364195
58Chronic otitis media (HP:0000389)2.72629596
59Myositis (HP:0100614)2.72349559
60Recurrent skin infections (HP:0001581)2.65217212
61Spontaneous hematomas (HP:0007420)2.62182797
62Skin rash (HP:0000988)2.61017784
63Systemic lupus erythematosus (HP:0002725)2.58103242
64Arthralgia (HP:0002829)2.56905395
65Chronic sinusitis (HP:0011109)2.52265720
66Abnormality of the prostate (HP:0008775)2.49926107
67Combined immunodeficiency (HP:0005387)2.48701518
68T lymphocytopenia (HP:0005403)2.48450909
69Sepsis (HP:0100806)2.48266266
70Abnormality of eosinophils (HP:0001879)2.48203972
71Recurrent otitis media (HP:0000403)2.44217458
72Hemoptysis (HP:0002105)2.39019701
73Basal cell carcinoma (HP:0002671)2.34421348
74Keratoconjunctivitis sicca (HP:0001097)2.29459016
75Joint swelling (HP:0001386)2.27607083
76Gastrointestinal infarctions (HP:0005244)2.27408957
77Gangrene (HP:0100758)2.24207808
78Obstructive lung disease (HP:0006536)2.23179944
79Chronic obstructive pulmonary disease (HP:0006510)2.23179944
80Abnormality of the pleura (HP:0002103)2.18116769
81Leukocytosis (HP:0001974)2.12338863
82Keratoconjunctivitis (HP:0001096)2.10045122
83Viral hepatitis (HP:0006562)2.08595329
84Pulmonary embolism (HP:0002204)2.05417336
85Thyroiditis (HP:0100646)2.04557889
86Carpal bone hypoplasia (HP:0001498)2.03061925
87Neutropenia (HP:0001875)2.01712553
88Recurrent gram-negative bacterial infections (HP:0005420)2.00528679
89Petechiae (HP:0000967)1.99911983
90Skin ulcer (HP:0200042)1.99406836
91Hypertensive crisis (HP:0100735)1.96864245
92Hepatitis (HP:0012115)1.94216326
93Arterial thrombosis (HP:0004420)1.93650558
94Mesangial abnormality (HP:0001966)1.83870902
95Pulmonary fibrosis (HP:0002206)1.81841283
96Chest pain (HP:0100749)1.79921588
97Prostate neoplasm (HP:0100787)1.78848475
98Purpura (HP:0000979)1.78326362
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.78153049
100Xerostomia (HP:0000217)1.78108992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.74957050
2RIPK43.93415740
3PRPF4B3.69275136
4SYK2.74258080
5ERN12.62327262
6BLK2.61622194
7MAP3K142.52204062
8JAK12.51600733
9NEK92.48176643
10TYK22.31148522
11FGFR42.19108320
12IKBKE2.11115284
13IRAK42.09067733
14SMG12.04891757
15EIF2AK32.04109753
16TBK12.01585883
17JAK31.92112817
18CSF1R1.81647829
19VRK11.79329396
20BTK1.79318070
21KIT1.63497199
22TLK11.59716044
23LYN1.56060406
24IKBKB1.52395625
25STK241.47169323
26PRKCQ1.42068722
27SIK21.40385129
28MAP3K131.37668661
29FGFR31.34283853
30NLK1.31241174
31CSK1.28729038
32PASK1.25741953
33BMPR21.17032125
34CCNB11.12950312
35MAPK111.12008486
36MAP3K101.11061080
37FGR1.10779999
38HCK1.08702756
39JAK21.07352295
40TESK21.06621641
41LCK1.05440744
42ITK1.00690433
43RPS6KA51.00369565
44FES0.97411476
45STK100.96907157
46DAPK30.96762854
47PIM10.94170280
48ZAP700.85827232
49CDK40.83392857
50TNK20.82917111
51EPHA30.80336781
52DDR20.79127745
53TAOK30.77959372
54MAPK120.76262372
55MELK0.73421064
56BCR0.72586011
57PDK10.70540194
58MAPK70.70368806
59TEC0.69879060
60HIPK20.68574846
61PKN10.68264814
62PRKCH0.68233062
63MAPK40.68205311
64SIK30.67695359
65ZAK0.67616803
66MAP2K30.67276471
67CDC42BPA0.66457036
68MST1R0.65577493
69KDR0.64557849
70TRIB30.62008189
71TAOK20.61051032
72CDK190.59042706
73CDK120.55850610
74CAMKK10.54638826
75CHUK0.54075141
76MAPKAPK20.51943948
77LRRK20.51862263
78MAP3K80.51351980
79TAF10.44394178
80PIM20.44387977
81MAPKAPK30.42442586
82MAP3K30.42392844
83PRKCD0.42374895
84RPS6KB20.41786100
85INSR0.41781300
86TYRO30.40101941
87CDC70.38644840
88STK40.38121981
89IRAK10.37628010
90MATK0.37180964
91BCKDK0.36069168
92FYN0.35514615
93EEF2K0.34702923
94CDK90.33966647
95BRAF0.33556535
96TXK0.33395201
97MARK30.33272103
98MAP3K110.32723857
99ARAF0.32648339
100MAP3K50.32609918

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.85317291
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.63578076
3Autoimmune thyroid disease_Homo sapiens_hsa053204.45956709
4Graft-versus-host disease_Homo sapiens_hsa053324.35819246
5Primary immunodeficiency_Homo sapiens_hsa053404.27083397
6Asthma_Homo sapiens_hsa053104.00053560
7Type I diabetes mellitus_Homo sapiens_hsa049403.68035406
8Systemic lupus erythematosus_Homo sapiens_hsa053223.16499891
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.72109752
10Viral myocarditis_Homo sapiens_hsa054162.65962818
11Staphylococcus aureus infection_Homo sapiens_hsa051502.60704231
12Antigen processing and presentation_Homo sapiens_hsa046122.57789811
13Leishmaniasis_Homo sapiens_hsa051402.50652846
14B cell receptor signaling pathway_Homo sapiens_hsa046622.44273176
15Influenza A_Homo sapiens_hsa051641.89173817
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.85161433
17Measles_Homo sapiens_hsa051621.79026389
18Herpes simplex infection_Homo sapiens_hsa051681.76492933
19Rheumatoid arthritis_Homo sapiens_hsa053231.55626882
20Hematopoietic cell lineage_Homo sapiens_hsa046401.52608437
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51640461
22Toxoplasmosis_Homo sapiens_hsa051451.45597119
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38533048
24Tuberculosis_Homo sapiens_hsa051521.31874151
25Alcoholism_Homo sapiens_hsa050341.29215040
26T cell receptor signaling pathway_Homo sapiens_hsa046601.28397617
27Osteoclast differentiation_Homo sapiens_hsa043801.25319602
28Viral carcinogenesis_Homo sapiens_hsa052031.20671789
29Epstein-Barr virus infection_Homo sapiens_hsa051691.15935662
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13780868
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04363361
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01657035
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99952340
34TNF signaling pathway_Homo sapiens_hsa046680.98350997
35Hepatitis B_Homo sapiens_hsa051610.87059671
36Chemokine signaling pathway_Homo sapiens_hsa040620.84504730
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.82828727
38Apoptosis_Homo sapiens_hsa042100.82701877
39HTLV-I infection_Homo sapiens_hsa051660.81801190
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78656953
41Phagosome_Homo sapiens_hsa041450.76024044
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71241430
43Hepatitis C_Homo sapiens_hsa051600.71080225
44African trypanosomiasis_Homo sapiens_hsa051430.68740692
45Pertussis_Homo sapiens_hsa051330.66477689
46Malaria_Homo sapiens_hsa051440.62042269
47Acute myeloid leukemia_Homo sapiens_hsa052210.61737893
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61737664
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60154126
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47087774
51Legionellosis_Homo sapiens_hsa051340.47068463
52Pancreatic cancer_Homo sapiens_hsa052120.42791287
53Non-small cell lung cancer_Homo sapiens_hsa052230.40406716
54Prolactin signaling pathway_Homo sapiens_hsa049170.39537983
55Shigellosis_Homo sapiens_hsa051310.37230651
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37172422
57p53 signaling pathway_Homo sapiens_hsa041150.34455273
58DNA replication_Homo sapiens_hsa030300.33685599
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.30778185
60Homologous recombination_Homo sapiens_hsa034400.29361059
61Dorso-ventral axis formation_Homo sapiens_hsa043200.29343987
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.27762571
63VEGF signaling pathway_Homo sapiens_hsa043700.27528676
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26130644
65Chronic myeloid leukemia_Homo sapiens_hsa052200.24498010
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22949364
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.21917365
68Salmonella infection_Homo sapiens_hsa051320.21280526
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21248173
70Platelet activation_Homo sapiens_hsa046110.19753318
71One carbon pool by folate_Homo sapiens_hsa006700.18254906
72HIF-1 signaling pathway_Homo sapiens_hsa040660.15253205
73Prion diseases_Homo sapiens_hsa050200.14715480
74MAPK signaling pathway_Homo sapiens_hsa040100.13051389
75Base excision repair_Homo sapiens_hsa034100.12820141
76Colorectal cancer_Homo sapiens_hsa052100.08352353
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08316007
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07874965
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.07649346
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07239822
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07203378
82Fructose and mannose metabolism_Homo sapiens_hsa000510.06864917
83GnRH signaling pathway_Homo sapiens_hsa049120.06321782
84Ribosome_Homo sapiens_hsa030100.05957276
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05729351
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05561191
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.04735606
88Prostate cancer_Homo sapiens_hsa052150.03939566
89Renal cell carcinoma_Homo sapiens_hsa052110.03676194
90Other glycan degradation_Homo sapiens_hsa005110.02222851
91Glioma_Homo sapiens_hsa052140.00704839
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00153158
93Endometrial cancer_Homo sapiens_hsa05213-0.0236691
94Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0212792
95Small cell lung cancer_Homo sapiens_hsa05222-0.0209127
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0191995
97Bladder cancer_Homo sapiens_hsa05219-0.0148883
98Lysosome_Homo sapiens_hsa04142-0.0114893
99Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0102508
100Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0027786

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