CHIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.92584050
2opsonization (GO:0008228)5.63789264
3male meiosis I (GO:0007141)5.57670059
4positive regulation of B cell differentiation (GO:0045579)5.05063053
5positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)4.97023774
6positive regulation of interleukin-1 beta secretion (GO:0050718)4.78765413
7regulation of rhodopsin mediated signaling pathway (GO:0022400)4.63692878
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.63415879
9positive regulation of interleukin-1 secretion (GO:0050716)4.59652032
10proteasome assembly (GO:0043248)4.49797319
11negative T cell selection (GO:0043383)4.38540504
12regulation of interleukin-1 beta secretion (GO:0050706)4.37293793
13rhodopsin mediated signaling pathway (GO:0016056)4.35023135
14carnitine metabolic process (GO:0009437)4.29486403
15meiosis I (GO:0007127)4.28304772
16fusion of sperm to egg plasma membrane (GO:0007342)4.24476782
17cellular response to zinc ion (GO:0071294)4.18312699
18dicarboxylic acid catabolic process (GO:0043649)4.08164252
19regulation of gamma-delta T cell differentiation (GO:0045586)4.05414909
20regulation of histone H3-K9 methylation (GO:0051570)4.04784905
21negative thymic T cell selection (GO:0045060)4.03768755
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.03645465
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98535945
24regulation of interleukin-1 secretion (GO:0050704)3.93409048
25plasma membrane fusion (GO:0045026)3.92837020
26activation of MAPKKK activity (GO:0000185)3.92669509
27tryptophan metabolic process (GO:0006568)3.81335461
28sex differentiation (GO:0007548)3.69774080
29toxin transport (GO:1901998)3.67458797
30positive thymic T cell selection (GO:0045059)3.62683906
31antigen processing and presentation of endogenous antigen (GO:0019883)3.59044084
32positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.51739798
33purine deoxyribonucleotide catabolic process (GO:0009155)3.49886671
34ketone body metabolic process (GO:1902224)3.48024021
35positive regulation of toll-like receptor signaling pathway (GO:0034123)3.44413481
36regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.43998837
37microtubule depolymerization (GO:0007019)3.38410085
38cellular ketone body metabolic process (GO:0046950)3.38285465
39behavioral response to ethanol (GO:0048149)3.35753161
40positive T cell selection (GO:0043368)3.34942438
41immunoglobulin mediated immune response (GO:0016064)3.33300357
42amino-acid betaine metabolic process (GO:0006577)3.33077449
43axonemal dynein complex assembly (GO:0070286)3.31561680
44thymic T cell selection (GO:0045061)3.31328089
45negative regulation of T cell apoptotic process (GO:0070233)3.31159422
46aspartate family amino acid catabolic process (GO:0009068)3.30657397
47positive regulation of ERBB signaling pathway (GO:1901186)3.28976861
48indole-containing compound catabolic process (GO:0042436)3.28849031
49indolalkylamine catabolic process (GO:0046218)3.28849031
50tryptophan catabolic process (GO:0006569)3.28849031
51sperm motility (GO:0030317)3.25961847
52regulation of gamma-delta T cell activation (GO:0046643)3.25288094
53indolalkylamine metabolic process (GO:0006586)3.22282647
54regulation of triglyceride catabolic process (GO:0010896)3.21536725
55microtubule polymerization or depolymerization (GO:0031109)3.21477168
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.20737642
57positive regulation of tolerance induction (GO:0002645)3.20192384
58positive regulation of interleukin-1 beta production (GO:0032731)3.20143021
59negative regulation of macrophage differentiation (GO:0045650)3.11360468
60bicarbonate transport (GO:0015701)3.09941145
61organic cation transport (GO:0015695)3.08684734
62positive regulation of interleukin-4 production (GO:0032753)3.05115649
63cytokine biosynthetic process (GO:0042089)3.03362447
64DNA deamination (GO:0045006)3.02651314
65positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96830188
66phosphate ion homeostasis (GO:0055062)2.96111933
67trivalent inorganic anion homeostasis (GO:0072506)2.96111933
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92994195
69epithelial cilium movement (GO:0003351)2.90410095
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86352311
71deoxyribonucleotide catabolic process (GO:0009264)2.84847459
72positive regulation of interleukin-1 production (GO:0032732)2.81897662
73regulation of T cell tolerance induction (GO:0002664)2.81710321
74microtubule severing (GO:0051013)2.81555496
75platelet dense granule organization (GO:0060155)2.81541675
76multicellular organism reproduction (GO:0032504)2.80609017
77glyoxylate metabolic process (GO:0046487)2.79277475
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78150774
79arginine catabolic process (GO:0006527)2.76610822
80positive regulation of circadian rhythm (GO:0042753)2.71282521
81negative regulation of mast cell activation (GO:0033004)2.67950771
82positive regulation of glomerulus development (GO:0090193)2.67292558
83regulation of B cell differentiation (GO:0045577)2.66865929
84kynurenine metabolic process (GO:0070189)2.63821507
85cilium movement (GO:0003341)2.60547152
86peptidyl-histidine modification (GO:0018202)2.57793810
87T cell selection (GO:0045058)2.57603987
88one-carbon compound transport (GO:0019755)2.57389816
89positive regulation of gamma-delta T cell activation (GO:0046645)2.56310163
90water-soluble vitamin biosynthetic process (GO:0042364)2.56072726
91bile acid biosynthetic process (GO:0006699)2.55379425
92nephron tubule formation (GO:0072079)2.54995477
93acrosome reaction (GO:0007340)2.54492509
94grooming behavior (GO:0007625)2.54170247
95cytokine metabolic process (GO:0042107)2.52664483
96positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52212439
97sulfation (GO:0051923)2.51790335
98regulation of alpha-beta T cell proliferation (GO:0046640)2.50684135
99detection of light stimulus involved in sensory perception (GO:0050962)2.48502083
100detection of light stimulus involved in visual perception (GO:0050908)2.48502083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.13714425
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.49625568
3ZNF274_21170338_ChIP-Seq_K562_Hela3.67912145
4EZH2_22144423_ChIP-Seq_EOC_Human3.66873236
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.96081223
6IGF1R_20145208_ChIP-Seq_DFB_Human2.95638608
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66687021
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29942206
9VDR_22108803_ChIP-Seq_LS180_Human2.23068023
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.17212916
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.12089825
12BCAT_22108803_ChIP-Seq_LS180_Human2.11464048
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91230672
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88953346
15ER_23166858_ChIP-Seq_MCF-7_Human1.79665741
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78307206
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69533757
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.65420508
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58897570
20CBP_20019798_ChIP-Seq_JUKART_Human1.58897570
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58125608
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57304452
23ERG_20517297_ChIP-Seq_VCAP_Human1.56925677
24KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51887684
25* AR_20517297_ChIP-Seq_VCAP_Human1.47987317
26GBX2_23144817_ChIP-Seq_PC3_Human1.47610740
27MYC_19829295_ChIP-Seq_ESCs_Human1.44611614
28* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.43283089
29FOXH1_21741376_ChIP-Seq_EPCs_Human1.41082253
30ERA_21632823_ChIP-Seq_H3396_Human1.40891445
31* NCOR_22424771_ChIP-Seq_293T_Human1.40699790
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39753694
33P300_19829295_ChIP-Seq_ESCs_Human1.39188983
34NANOG_20526341_ChIP-Seq_ESCs_Human1.36803551
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36044116
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.36044116
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35135506
38SOX2_19829295_ChIP-Seq_ESCs_Human1.33878985
39NANOG_19829295_ChIP-Seq_ESCs_Human1.33878985
40DROSHA_22980978_ChIP-Seq_HELA_Human1.33479234
41RUNX_20019798_ChIP-Seq_JUKART_Human1.33425551
42* GATA3_26560356_Chip-Seq_TH2_Human1.33121989
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29337672
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29279906
45* RBPJ_21746931_ChIP-Seq_IB4_Human1.29047281
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.25651821
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23356768
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.22901190
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22763797
50* GATA6_21074721_ChIP-Seq_CACO-2_Human1.22304274
51STAT3_23295773_ChIP-Seq_U87_Human1.21922364
52CDX2_22108803_ChIP-Seq_LS180_Human1.21221166
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20677056
54* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19806465
55SMAD4_21799915_ChIP-Seq_A2780_Human1.17766278
56TCF4_22108803_ChIP-Seq_LS180_Human1.17691554
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16171101
58* ETV1_20927104_ChIP-Seq_GIST48_Human1.14750868
59PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14719936
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14042306
61* SMRT_27268052_Chip-Seq_Bcells_Human1.13787460
62HOXB7_26014856_ChIP-Seq_BT474_Human1.13537799
63* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13308185
64* HNFA_21074721_ChIP-Seq_CACO-2_Human1.12303609
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11794111
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11506324
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.10295359
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.10216057
69TP53_22573176_ChIP-Seq_HFKS_Human1.09833997
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09789609
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.08891403
72* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08457861
73* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08167780
74TCF4_23295773_ChIP-Seq_U87_Human1.07896658
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07729293
76PHF8_20622853_ChIP-Seq_HELA_Human1.06942955
77OCT4_20526341_ChIP-Seq_ESCs_Human1.06333726
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06281429
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05089451
80AR_25329375_ChIP-Seq_VCAP_Human1.04307718
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03977924
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03971590
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.03764605
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03637594
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.00783554
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.00723952
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00697809
88RUNX2_22187159_ChIP-Seq_PCA_Human0.99804303
89* YY1_22570637_ChIP-Seq_MALME-3M_Human0.99464114
90TAF2_19829295_ChIP-Seq_ESCs_Human0.99336375
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99168051
92* P53_21459846_ChIP-Seq_SAOS-2_Human0.98517586
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98232340
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97946485
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97351889
96E2F1_20622854_ChIP-Seq_HELA_Human0.97276882
97STAT1_20625510_ChIP-Seq_HELA_Human0.97070844
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96508606
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96336485
100CJUN_26792858_Chip-Seq_BT549_Human0.95990025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.30174020
2MP0003878_abnormal_ear_physiology4.30174020
3MP0002138_abnormal_hepatobiliary_system3.81777638
4MP0005410_abnormal_fertilization3.51878294
5MP0003646_muscle_fatigue3.46801409
6MP0005646_abnormal_pituitary_gland3.42975818
7MP0001764_abnormal_homeostasis3.08439325
8MP0003806_abnormal_nucleotide_metabolis2.84343448
9MP0001835_abnormal_antigen_presentation2.82579607
10MP0005085_abnormal_gallbladder_physiolo2.73764656
11MP0008872_abnormal_physiological_respon2.44769033
12MP0005551_abnormal_eye_electrophysiolog2.34993746
13MP0003195_calcinosis2.26246057
14MP0005671_abnormal_response_to1.89059935
15MP0002277_abnormal_respiratory_mucosa1.84249832
16MP0003011_delayed_dark_adaptation1.80517974
17MP0005645_abnormal_hypothalamus_physiol1.75428144
18MP0000372_irregular_coat_pigmentation1.65409054
19MP0003252_abnormal_bile_duct1.56855222
20MP0002166_altered_tumor_susceptibility1.56843875
21MP0004782_abnormal_surfactant_physiolog1.53646560
22MP0003698_abnormal_male_reproductive1.51000691
23MP0009333_abnormal_splenocyte_physiolog1.49214028
24MP0005257_abnormal_intraocular_pressure1.44836703
25MP0001663_abnormal_digestive_system1.43630147
26MP0001800_abnormal_humoral_immune1.41102599
27MP0001440_abnormal_grooming_behavior1.39623377
28MP0001501_abnormal_sleep_pattern1.39501213
29MP0005670_abnormal_white_adipose1.39043587
30MP0009785_altered_susceptibility_to1.38245437
31MP0003136_yellow_coat_color1.38161470
32MP0000678_abnormal_parathyroid_gland1.32597017
33MP0005253_abnormal_eye_physiology1.30713624
34MP0001929_abnormal_gametogenesis1.27952806
35MP0010386_abnormal_urinary_bladder1.27762831
36MP0001765_abnormal_ion_homeostasis1.25641692
37MP0008004_abnormal_stomach_pH1.25273566
38MP0005365_abnormal_bile_salt1.23869255
39MP0003045_fibrosis1.23395223
40MP0003879_abnormal_hair_cell1.23294790
41MP0005647_abnormal_sex_gland1.20569097
42MP0002148_abnormal_hypersensitivity_rea1.16478370
43MP0002006_tumorigenesis1.15677399
44MP0002139_abnormal_hepatobiliary_system1.15412789
45MP0001661_extended_life_span1.15172728
46MP0002723_abnormal_immune_serum1.14368703
47MP0008995_early_reproductive_senescence1.14220093
48MP0005000_abnormal_immune_tolerance1.11971179
49MP0005334_abnormal_fat_pad1.10787243
50MP0005332_abnormal_amino_acid1.10422405
51MP0005167_abnormal_blood-brain_barrier1.09487926
52MP0008875_abnormal_xenobiotic_pharmacok1.09254153
53MP0005360_urolithiasis1.08268922
54MP0003936_abnormal_reproductive_system1.07877109
55MP0003866_abnormal_defecation1.07663378
56MP0000538_abnormal_urinary_bladder1.06743830
57MP0001905_abnormal_dopamine_level1.06298097
58MP0005448_abnormal_energy_balance1.06137400
59MP0002095_abnormal_skin_pigmentation1.04858501
60MP0003724_increased_susceptibility_to1.04453378
61MP0009697_abnormal_copulation1.04007641
62MP0001968_abnormal_touch/_nociception1.01826972
63MP0000685_abnormal_immune_system0.98944280
64MP0009643_abnormal_urine_homeostasis0.98940939
65MP0004130_abnormal_muscle_cell0.98101319
66MP0002102_abnormal_ear_morphology0.97814552
67MP0005376_homeostasis/metabolism_phenot0.97099628
68MP0002452_abnormal_antigen_presenting0.95672410
69MP0000230_abnormal_systemic_arterial0.93385149
70MP0000716_abnormal_immune_system0.93016116
71MP0000516_abnormal_urinary_system0.92688362
72MP0005367_renal/urinary_system_phenotyp0.92688362
73MP0005025_abnormal_response_to0.92036996
74MP0002876_abnormal_thyroid_physiology0.91059873
75MP0001486_abnormal_startle_reflex0.90790430
76MP0002736_abnormal_nociception_after0.89065095
77MP0008469_abnormal_protein_level0.88602361
78MP0002693_abnormal_pancreas_physiology0.87902567
79MP0002405_respiratory_system_inflammati0.87568695
80MP0002420_abnormal_adaptive_immunity0.87410914
81MP0001485_abnormal_pinna_reflex0.85790944
82MP0009745_abnormal_behavioral_response0.84554657
83MP0001819_abnormal_immune_cell0.84523545
84MP0003868_abnormal_feces_composition0.82683573
85MP0010368_abnormal_lymphatic_system0.80064546
86MP0006036_abnormal_mitochondrial_physio0.79277213
87MP0002332_abnormal_exercise_endurance0.78725312
88MP0005381_digestive/alimentary_phenotyp0.77691501
89MP0005636_abnormal_mineral_homeostasis0.76863072
90MP0000470_abnormal_stomach_morphology0.73541028
91MP0005535_abnormal_body_temperature0.73055007
92MP0001790_abnormal_immune_system0.73007147
93MP0005387_immune_system_phenotype0.73007147
94MP0003638_abnormal_response/metabolism_0.72518699
95MP0010155_abnormal_intestine_physiology0.72040353
96MP0002118_abnormal_lipid_homeostasis0.71265217
97MP0003950_abnormal_plasma_membrane0.71185941
98MP0004019_abnormal_vitamin_homeostasis0.69936497
99MP0004043_abnormal_pH_regulation0.69540916
100MP0005595_abnormal_vascular_smooth0.68859220

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)8.83940477
2Genetic anticipation (HP:0003743)5.00800324
3Decreased central vision (HP:0007663)4.52001379
4Progressive cerebellar ataxia (HP:0002073)3.77938274
5Stomach cancer (HP:0012126)3.58060324
6Pancreatic cysts (HP:0001737)3.54545277
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45389865
8Tubulointerstitial nephritis (HP:0001970)3.44674440
9Congenital sensorineural hearing impairment (HP:0008527)3.42867590
10Anhidrosis (HP:0000970)3.34168380
11Abnormal ciliary motility (HP:0012262)3.27070661
12Tetany (HP:0001281)3.21409223
13Chronic hepatic failure (HP:0100626)3.04263584
14Abnormal respiratory motile cilium physiology (HP:0012261)3.03259081
15Poikiloderma (HP:0001029)3.02618385
16Dysautonomia (HP:0002459)3.01156640
17Nasal polyposis (HP:0100582)2.94183257
18Spastic paraparesis (HP:0002313)2.94051756
19Dry hair (HP:0011359)2.92662001
20Abnormal respiratory motile cilium morphology (HP:0005938)2.91993217
21Abnormal respiratory epithelium morphology (HP:0012253)2.91993217
22Keratoconus (HP:0000563)2.90895818
23Increased corneal curvature (HP:0100692)2.90895818
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85163948
25Abnormal drinking behavior (HP:0030082)2.82363013
26Polydipsia (HP:0001959)2.82363013
27Chronic otitis media (HP:0000389)2.78640583
28Abnormality of DNA repair (HP:0003254)2.75925701
29Absent/shortened dynein arms (HP:0200106)2.75802448
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.75802448
31Congenital stationary night blindness (HP:0007642)2.75459981
32Abnormal rod and cone electroretinograms (HP:0008323)2.69264882
33Tubulointerstitial abnormality (HP:0001969)2.66431133
34Reduced antithrombin III activity (HP:0001976)2.62327931
35Severe visual impairment (HP:0001141)2.58244219
36Neoplasm of the adrenal cortex (HP:0100641)2.55786304
37Optic disc pallor (HP:0000543)2.53111551
38Ketosis (HP:0001946)2.49050273
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43733812
40Bony spicule pigmentary retinopathy (HP:0007737)2.41662437
41True hermaphroditism (HP:0010459)2.39770374
42Cystic liver disease (HP:0006706)2.36533908
43Chronic sinusitis (HP:0011109)2.36378866
44Enlarged kidneys (HP:0000105)2.35431434
45Generalized aminoaciduria (HP:0002909)2.32494823
46Pancreatic fibrosis (HP:0100732)2.31260776
47Abnormality of the nasal mucosa (HP:0000433)2.29892439
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29470140
49Macular degeneration (HP:0000608)2.27938155
50Abnormality of pyrimidine metabolism (HP:0004353)2.27726762
51Polyuria (HP:0000103)2.26562515
52Abnormal urine output (HP:0012590)2.23808149
53Entropion (HP:0000621)2.22469237
54Neonatal hypoglycemia (HP:0001998)2.20141552
55Decreased circulating renin level (HP:0003351)2.20008410
56Facial shape deformation (HP:0011334)2.19250763
57Potter facies (HP:0002009)2.19250763
58Tubulointerstitial fibrosis (HP:0005576)2.19188434
59Increased IgM level (HP:0003496)2.17848272
60Hyperammonemia (HP:0001987)2.16246966
61Photophobia (HP:0000613)2.14856213
62Joint swelling (HP:0001386)2.13416440
63Abnormality of dental color (HP:0011073)2.13266519
64Rhinitis (HP:0012384)2.12694581
65Cutaneous melanoma (HP:0012056)2.10966088
66Gastrointestinal infarctions (HP:0005244)2.10545912
67Abnormality of renal excretion (HP:0011036)2.08314072
68Paraparesis (HP:0002385)2.07250281
69Increased serum pyruvate (HP:0003542)2.04742257
70Hypophosphatemic rickets (HP:0004912)2.00132382
71Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98593605
72Bronchiectasis (HP:0002110)1.98499834
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94810541
74Increased neuronal autofluorescent lipopigment (HP:0002074)1.94632507
75Alkalosis (HP:0001948)1.94528863
76Male infertility (HP:0003251)1.92422419
77Conical tooth (HP:0000698)1.90209274
78Abnormal pancreas size (HP:0012094)1.88943344
79Pendular nystagmus (HP:0012043)1.88773613
80Inflammation of the large intestine (HP:0002037)1.88249851
81Acute hepatic failure (HP:0006554)1.87882958
82Thyroiditis (HP:0100646)1.86840273
83Hypokalemic alkalosis (HP:0001949)1.86242699
84Absent thumb (HP:0009777)1.84248059
85Congenital hepatic fibrosis (HP:0002612)1.83937183
86Type II diabetes mellitus (HP:0005978)1.82189192
87Respiratory distress (HP:0002098)1.80611303
88Febrile seizures (HP:0002373)1.77125006
89Abnormality of binocular vision (HP:0011514)1.73822899
90Diplopia (HP:0000651)1.73822899
91Diastasis recti (HP:0001540)1.73499620
92Furrowed tongue (HP:0000221)1.72809976
93Severe combined immunodeficiency (HP:0004430)1.71229868
94Hypoglycemic coma (HP:0001325)1.70500246
95Malignant hyperthermia (HP:0002047)1.69823653
96Abnormality of renin-angiotensin system (HP:0000847)1.69292959
97Amelogenesis imperfecta (HP:0000705)1.69158372
98Abnormal autonomic nervous system physiology (HP:0012332)1.68605600
99Alacrima (HP:0000522)1.66990194
100Median cleft lip (HP:0000161)1.65770494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.43072556
2FRK4.81642660
3MAP3K124.79009490
4MUSK4.13815747
5MAP4K13.24440724
6MAPKAPK33.03956894
7TAOK32.86905029
8PIK3CG2.79086664
9BCKDK2.58677429
10ADRBK12.58098134
11TLK12.36830363
12CSF1R2.22515669
13ACVR1B2.19844727
14ZAK1.89337460
15LIMK11.88182311
16PLK41.79007346
17BMPR1B1.70259887
18CAMK1D1.54433766
19MAP3K51.38406830
20IKBKE1.33265495
21CAMKK21.32504682
22ADRBK21.31044031
23PRPF4B1.30012422
24PDK11.24055831
25MAP3K111.22912419
26PIK3CA1.20160414
27KDR1.18477761
28GRK11.17880977
29EIF2AK31.15288876
30CAMK1G1.08689609
31INSRR1.06826452
32PINK10.99088326
33PLK20.95969650
34IKBKB0.94618331
35TAOK20.90110154
36TBK10.89582081
37TIE10.88767896
38WNK40.85756908
39FES0.85003609
40MYLK0.83058980
41CAMKK10.82101163
42DYRK20.80330490
43STK38L0.79921774
44SYK0.77556764
45TYK20.76704064
46CHUK0.76514545
47MAP4K20.74307210
48DAPK10.73922316
49FGFR20.73916408
50TGFBR10.72081686
51PDPK10.71794829
52TESK10.70793789
53PRKCQ0.68685237
54ZAP700.68557563
55RIPK10.66011803
56MELK0.64279548
57ABL20.63974495
58NEK20.63053832
59LCK0.62754905
60IRAK40.62132398
61DAPK20.61797883
62PAK60.61401024
63NEK60.55720858
64FER0.53822352
65SCYL20.53618365
66IGF1R0.53009703
67ITK0.52647665
68PASK0.47948374
69PRKD10.47620338
70CHEK20.46989584
71LATS10.46189891
72OXSR10.45086750
73PTK2B0.44036146
74PRKCE0.43516682
75GRK50.41776721
76VRK20.41182984
77MARK30.39313560
78MAPK30.37852107
79TXK0.37652568
80RPS6KB10.36354118
81ABL10.35049720
82BRD40.33823796
83ERBB20.33749787
84JAK10.31854650
85EGFR0.29046397
86MAPK110.28948140
87WNK30.28044933
88DDR20.27989464
89OBSCN0.27799544
90RPS6KA50.27539856
91PDK20.27113295
92IRAK20.26479736
93PRKCA0.24763615
94MAPK130.24117082
95CAMK10.23723722
96CAMK40.22380184
97MST1R0.22312515
98MAPK150.21660638
99MAP3K100.21347750
100MAP2K60.21061526

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.31043129
2Nitrogen metabolism_Homo sapiens_hsa009103.49106869
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.28679180
4Graft-versus-host disease_Homo sapiens_hsa053322.78845386
5Linoleic acid metabolism_Homo sapiens_hsa005912.71837407
6Allograft rejection_Homo sapiens_hsa053302.39853346
7Autoimmune thyroid disease_Homo sapiens_hsa053202.31278136
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25674847
9Tryptophan metabolism_Homo sapiens_hsa003802.12294611
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.05849642
11Arginine biosynthesis_Homo sapiens_hsa002201.97114992
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.89080914
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88180163
14Type I diabetes mellitus_Homo sapiens_hsa049401.76615395
15Chemical carcinogenesis_Homo sapiens_hsa052041.75558836
16Butanoate metabolism_Homo sapiens_hsa006501.75525611
17Arachidonic acid metabolism_Homo sapiens_hsa005901.74462939
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71736830
19Retinol metabolism_Homo sapiens_hsa008301.71390484
20Primary immunodeficiency_Homo sapiens_hsa053401.62249791
21Asthma_Homo sapiens_hsa053101.57067214
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56475982
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52482743
24Olfactory transduction_Homo sapiens_hsa047401.52118934
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50520241
26Staphylococcus aureus infection_Homo sapiens_hsa051501.46356250
27Antigen processing and presentation_Homo sapiens_hsa046121.42283266
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33379595
29Homologous recombination_Homo sapiens_hsa034401.33306868
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29974129
31Fat digestion and absorption_Homo sapiens_hsa049751.24713020
32Nicotine addiction_Homo sapiens_hsa050331.23782327
33Peroxisome_Homo sapiens_hsa041461.19262346
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18656524
35Propanoate metabolism_Homo sapiens_hsa006401.18375120
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17779938
37Selenocompound metabolism_Homo sapiens_hsa004501.17078810
38Complement and coagulation cascades_Homo sapiens_hsa046101.16079501
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12091202
40Circadian rhythm_Homo sapiens_hsa047101.05723284
41beta-Alanine metabolism_Homo sapiens_hsa004101.05503601
42Viral myocarditis_Homo sapiens_hsa054160.99319923
43Fatty acid degradation_Homo sapiens_hsa000710.98108946
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.97663782
45Rheumatoid arthritis_Homo sapiens_hsa053230.97434041
46Taste transduction_Homo sapiens_hsa047420.96198161
47Fatty acid elongation_Homo sapiens_hsa000620.95835667
48Salivary secretion_Homo sapiens_hsa049700.92204437
49ABC transporters_Homo sapiens_hsa020100.90822036
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90753248
51PPAR signaling pathway_Homo sapiens_hsa033200.87702202
52Renin-angiotensin system_Homo sapiens_hsa046140.87473821
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84745771
54Pertussis_Homo sapiens_hsa051330.83275309
55Hematopoietic cell lineage_Homo sapiens_hsa046400.82073878
56Lysine degradation_Homo sapiens_hsa003100.81907806
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76632677
58RNA polymerase_Homo sapiens_hsa030200.73696213
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72641474
60Purine metabolism_Homo sapiens_hsa002300.72447562
61Base excision repair_Homo sapiens_hsa034100.71595535
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71339748
63Malaria_Homo sapiens_hsa051440.70036310
64Glycerolipid metabolism_Homo sapiens_hsa005610.68934795
65Ether lipid metabolism_Homo sapiens_hsa005650.68708619
66Mineral absorption_Homo sapiens_hsa049780.68080223
67Fanconi anemia pathway_Homo sapiens_hsa034600.66818843
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.63511951
69Ovarian steroidogenesis_Homo sapiens_hsa049130.62379356
70Hedgehog signaling pathway_Homo sapiens_hsa043400.62296070
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.61862373
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55930083
73Fatty acid metabolism_Homo sapiens_hsa012120.54668694
74Histidine metabolism_Homo sapiens_hsa003400.51949533
75Systemic lupus erythematosus_Homo sapiens_hsa053220.50895640
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.49515987
77Herpes simplex infection_Homo sapiens_hsa051680.49027133
78Legionellosis_Homo sapiens_hsa051340.45625902
79Caffeine metabolism_Homo sapiens_hsa002320.44903728
80Pyrimidine metabolism_Homo sapiens_hsa002400.44042195
81African trypanosomiasis_Homo sapiens_hsa051430.42969579
82Circadian entrainment_Homo sapiens_hsa047130.42688858
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42324068
84Starch and sucrose metabolism_Homo sapiens_hsa005000.39876893
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38811849
86Tyrosine metabolism_Homo sapiens_hsa003500.37992345
87Measles_Homo sapiens_hsa051620.37367025
88Calcium signaling pathway_Homo sapiens_hsa040200.35560077
89Shigellosis_Homo sapiens_hsa051310.34477886
90Fatty acid biosynthesis_Homo sapiens_hsa000610.32487432
91Glutamatergic synapse_Homo sapiens_hsa047240.31711375
92Serotonergic synapse_Homo sapiens_hsa047260.29973521
93Bile secretion_Homo sapiens_hsa049760.26448627
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24517769
95Leishmaniasis_Homo sapiens_hsa051400.23727863
96Sphingolipid metabolism_Homo sapiens_hsa006000.23502757
97Morphine addiction_Homo sapiens_hsa050320.22972505
98* Metabolic pathways_Homo sapiens_hsa011000.21344097
99Nucleotide excision repair_Homo sapiens_hsa034200.20864387
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20298199

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