ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.90807670
2	fucose catabolic process (GO:0019317)	3.89001891
3	L-fucose metabolic process (GO:0042354)	3.89001891
4	L-fucose catabolic process (GO:0042355)	3.89001891
5	platelet dense granule organization (GO:0060155)	3.77004623
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.74056062
7	negative regulation of telomere maintenance (GO:0032205)	3.63615102
8	protein complex biogenesis (GO:0070271)	3.50402225
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.49614508
10	protein polyglutamylation (GO:0018095)	3.43027610
11	indole-containing compound catabolic process (GO:0042436)	3.35927439
12	indolalkylamine catabolic process (GO:0046218)	3.35927439
13	tryptophan catabolic process (GO:0006569)	3.35927439
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.32571016
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.32571016
16	NADH dehydrogenase complex assembly (GO:0010257)	3.32571016
17	indolalkylamine metabolic process (GO:0006586)	3.31958732
18	kynurenine metabolic process (GO:0070189)	3.31497392
19	ATP synthesis coupled proton transport (GO:0015986)	3.31421780
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.31421780
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.30508604
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.29792102
23	detection of light stimulus involved in visual perception (GO:0050908)	3.29792102
24	behavioral response to ethanol (GO:0048149)	3.26143138
25	response to pheromone (GO:0019236)	3.25760207
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19671360
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19090806
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.14987366
29	neuronal action potential (GO:0019228)	3.13265321
30	cellular ketone body metabolic process (GO:0046950)	3.12954331
31	piRNA metabolic process (GO:0034587)	3.08685490
32	cell proliferation in forebrain (GO:0021846)	3.06842792
33	axoneme assembly (GO:0035082)	3.05464112
34	epithelial cilium movement (GO:0003351)	3.02548988
35	water-soluble vitamin biosynthetic process (GO:0042364)	2.98179687
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.95699012
37	nonmotile primary cilium assembly (GO:0035058)	2.94008676
38	neural tube formation (GO:0001841)	2.92970684
39	pyrimidine nucleobase catabolic process (GO:0006208)	2.92654481
40	adaptation of signaling pathway (GO:0023058)	2.92378268
41	tachykinin receptor signaling pathway (GO:0007217)	2.91573624
42	electron transport chain (GO:0022900)	2.90998110
43	regulation of cilium movement (GO:0003352)	2.89457296
44	tryptophan metabolic process (GO:0006568)	2.88493304
45	respiratory electron transport chain (GO:0022904)	2.86338497
46	synaptic transmission, cholinergic (GO:0007271)	2.84688491
47	regulation of action potential (GO:0098900)	2.84417424
48	ubiquinone biosynthetic process (GO:0006744)	2.83567491
49	multicellular organism reproduction (GO:0032504)	2.80063443
50	DNA deamination (GO:0045006)	2.79301660
51	ubiquinone metabolic process (GO:0006743)	2.77422884
52	photoreceptor cell development (GO:0042461)	2.77083310
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76368462
54	intraciliary transport (GO:0042073)	2.75467781
55	negative regulation of mast cell activation (GO:0033004)	2.75149195
56	ketone body metabolic process (GO:1902224)	2.74258934
57	retinal cone cell development (GO:0046549)	2.73880755
58	rhodopsin mediated signaling pathway (GO:0016056)	2.70068376
59	cilium morphogenesis (GO:0060271)	2.69327520
60	somite development (GO:0061053)	2.67859212
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66749194
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66749194
63	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.65450563
64	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61146348
65	mannosylation (GO:0097502)	2.61017619
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.60210960
67	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59449079
68	reflex (GO:0060004)	2.58973936
69	regulation of hippo signaling (GO:0035330)	2.58157269
70	membrane depolarization during action potential (GO:0086010)	2.57852683
71	postsynaptic membrane organization (GO:0001941)	2.57038266
72	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.54469815
73	cilium organization (GO:0044782)	2.54225263
74	sulfation (GO:0051923)	2.53880627
75	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.53858540
76	nucleobase catabolic process (GO:0046113)	2.53703902
77	alanine transport (GO:0032328)	2.53684907
78	protein localization to cilium (GO:0061512)	2.51115194
79	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50630079
80	protein neddylation (GO:0045116)	2.50029724
81	protein-cofactor linkage (GO:0018065)	2.49194719
82	inner ear receptor stereocilium organization (GO:0060122)	2.48498393
83	eye photoreceptor cell development (GO:0042462)	2.48249006
84	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.48022756
85	regulation of mitotic spindle checkpoint (GO:1903504)	2.48022756
86	hydrogen ion transmembrane transport (GO:1902600)	2.47878876
87	indole-containing compound metabolic process (GO:0042430)	2.47413446
88	proton transport (GO:0015992)	2.47046328
89	cilium assembly (GO:0042384)	2.46985638
90	cAMP catabolic process (GO:0006198)	2.46732809
91	hydrogen transport (GO:0006818)	2.44894510
92	GPI anchor metabolic process (GO:0006505)	2.43006474
93	serotonin receptor signaling pathway (GO:0007210)	2.42873399
94	anterograde synaptic vesicle transport (GO:0048490)	2.41631381
95	regulation of telomere maintenance (GO:0032204)	2.41258142
96	GTP biosynthetic process (GO:0006183)	2.40575378
97	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39082577
98	dopamine transport (GO:0015872)	2.38389455
99	glycerophospholipid catabolic process (GO:0046475)	2.38078978
100	cornea development in camera-type eye (GO:0061303)	2.37836878

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.22042869
2	VDR_22108803_ChIP-Seq_LS180_Human	3.27441810
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10564538
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.61890142
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56169007
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52791356
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43757091
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41289673
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.34523585
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16582330
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15937393
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10062247
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.06097891
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.02110991
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01550225
16	EWS_26573619_Chip-Seq_HEK293_Human	1.98137607
17	P300_19829295_ChIP-Seq_ESCs_Human	1.97026587
18	FUS_26573619_Chip-Seq_HEK293_Human	1.87683691
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.87482324
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87023252
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81417404
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.78197354
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77801710
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75972258
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67626577
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62377077
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62065281
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60648486
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.60323415
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54678773
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.49787984
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.47872388
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.46575868
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.46169744
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44548429
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44236286
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43165019
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.39412048
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39412048
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39014377
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38756750
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.38626177
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38208225
44	STAT3_23295773_ChIP-Seq_U87_Human	1.33967628
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33722525
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33632989
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33148181
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32782993
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32183536
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32127099
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31210719
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31210719
53	AR_25329375_ChIP-Seq_VCAP_Human	1.30267058
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29740616
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29264690
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27800671
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27800671
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27307716
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27254894
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27254894
61	TCF4_23295773_ChIP-Seq_U87_Human	1.26109182
62	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25944755
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25183140
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24627574
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23401739
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23274044
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22754151
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22625968
69	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.21415876
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.19495941
71	AR_20517297_ChIP-Seq_VCAP_Human	1.18294755
72	NCOR_22424771_ChIP-Seq_293T_Human	1.17269139
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16971427
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16501039
75	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.15537081
76	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14926702
77	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13784701
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13676393
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13446538
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12930819
81	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12673846
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11788315
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05223563
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05157205
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02916681
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02249416
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02165452
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01294829
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00715329
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00654490
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00579529
92	MYC_19829295_ChIP-Seq_ESCs_Human	1.00507174
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00448377
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00161405
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98950880
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97615083
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97252117
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96656931
99	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96401763
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96196678

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.62852735
2	MP0001968_abnormal_touch/_nociception	2.57124752
3	MP0008877_abnormal_DNA_methylation	2.56460492
4	MP0003136_yellow_coat_color	2.54405948
5	MP0005551_abnormal_eye_electrophysiolog	2.48791314
6	MP0003880_abnormal_central_pattern	2.42732507
7	MP0003787_abnormal_imprinting	2.36626770
8	MP0002638_abnormal_pupillary_reflex	2.27854234
9	MP0002102_abnormal_ear_morphology	2.22638972
10	MP0004133_heterotaxia	2.22473093
11	MP0002163_abnormal_gland_morphology	2.21978413
12	MP0002736_abnormal_nociception_after	2.14566976
13	MP0003195_calcinosis	2.07642359
14	MP0003011_delayed_dark_adaptation	2.07546720
15	MP0000569_abnormal_digit_pigmentation	2.07300172
16	MP0006072_abnormal_retinal_apoptosis	2.06792464
17	MP0006276_abnormal_autonomic_nervous	2.05302332
18	MP0009745_abnormal_behavioral_response	1.89077230
19	MP0001485_abnormal_pinna_reflex	1.85938338
20	MP0002928_abnormal_bile_duct	1.83680357
21	MP0005379_endocrine/exocrine_gland_phen	1.74489592
22	MP0002837_dystrophic_cardiac_calcinosis	1.72933516
23	MP0005084_abnormal_gallbladder_morpholo	1.71890823
24	MP0004142_abnormal_muscle_tone	1.69425440
25	MP0008875_abnormal_xenobiotic_pharmacok	1.67239050
26	MP0002653_abnormal_ependyma_morphology	1.65894200
27	MP0005253_abnormal_eye_physiology	1.63478662
28	MP0002277_abnormal_respiratory_mucosa	1.62891214
29	MP0005646_abnormal_pituitary_gland	1.62733481
30	MP0008872_abnormal_physiological_respon	1.60007851
31	MP0002272_abnormal_nervous_system	1.58528393
32	MP0000372_irregular_coat_pigmentation	1.56794427
33	MP0004885_abnormal_endolymph	1.54737264
34	MP0000631_abnormal_neuroendocrine_gland	1.50933292
35	MP0001986_abnormal_taste_sensitivity	1.50429635
36	MP0002735_abnormal_chemical_nociception	1.48042392
37	MP0002876_abnormal_thyroid_physiology	1.47619095
38	MP0004147_increased_porphyrin_level	1.47062059
39	MP0002572_abnormal_emotion/affect_behav	1.45085531
40	MP0002733_abnormal_thermal_nociception	1.44617440
41	MP0005423_abnormal_somatic_nervous	1.44580963
42	MP0009046_muscle_twitch	1.41962936
43	MP0005645_abnormal_hypothalamus_physiol	1.41603628
44	MP0002938_white_spotting	1.40883658
45	MP0003283_abnormal_digestive_organ	1.40594270
46	MP0001905_abnormal_dopamine_level	1.39644187
47	MP0004043_abnormal_pH_regulation	1.35782024
48	MP0004742_abnormal_vestibular_system	1.35164884
49	MP0001501_abnormal_sleep_pattern	1.33901421
50	MP0001970_abnormal_pain_threshold	1.33334572
51	MP0001529_abnormal_vocalization	1.28806795
52	MP0002557_abnormal_social/conspecific_i	1.27684229
53	MP0002234_abnormal_pharynx_morphology	1.27620788
54	MP0003635_abnormal_synaptic_transmissio	1.26355418
55	MP0000427_abnormal_hair_cycle	1.23693115
56	MP0001486_abnormal_startle_reflex	1.23094384
57	MP0009379_abnormal_foot_pigmentation	1.21569661
58	MP0002063_abnormal_learning/memory/cond	1.18792265
59	MP0002064_seizures	1.18407864
60	MP0008995_early_reproductive_senescence	1.18305378
61	MP0003121_genomic_imprinting	1.18088255
62	MP0003878_abnormal_ear_physiology	1.16712324
63	MP0005377_hearing/vestibular/ear_phenot	1.16712324
64	MP0003890_abnormal_embryonic-extraembry	1.15012057
65	MP0005195_abnormal_posterior_eye	1.14749999
66	MP0005389_reproductive_system_phenotype	1.13495678
67	MP0008789_abnormal_olfactory_epithelium	1.13324893
68	MP0003646_muscle_fatigue	1.11078682
69	MP0000049_abnormal_middle_ear	1.10486465
70	MP0005174_abnormal_tail_pigmentation	1.10132974
71	MP0000778_abnormal_nervous_system	1.09150102
72	MP0002067_abnormal_sensory_capabilities	1.05101145
73	MP0000566_synostosis	1.03097913
74	MP0002734_abnormal_mechanical_nocicepti	1.02833990
75	MP0003252_abnormal_bile_duct	1.00738457
76	MP0002138_abnormal_hepatobiliary_system	1.00204739
77	MP0001502_abnormal_circadian_rhythm	1.00189325
78	MP0002752_abnormal_somatic_nervous	0.99961920
79	MP0001984_abnormal_olfaction	0.98634763
80	MP0001293_anophthalmia	0.98607762
81	MP0004145_abnormal_muscle_electrophysio	0.98018446
82	MP0000026_abnormal_inner_ear	0.97882060
83	MP0001919_abnormal_reproductive_system	0.96624313
84	MP0003122_maternal_imprinting	0.91382202
85	MP0002160_abnormal_reproductive_system	0.90348383
86	MP0000230_abnormal_systemic_arterial	0.89101714
87	MP0001324_abnormal_eye_pigmentation	0.88926911
88	MP0001440_abnormal_grooming_behavior	0.87388618
89	MP0010386_abnormal_urinary_bladder	0.87188056
90	MP0002184_abnormal_innervation	0.87106269
91	MP0001963_abnormal_hearing_physiology	0.86081019
92	MP0005386_behavior/neurological_phenoty	0.85098439
93	MP0004924_abnormal_behavior	0.85098439
94	MP0005391_vision/eye_phenotype	0.81759870
95	MP0005410_abnormal_fertilization	0.81309389
96	MP0002095_abnormal_skin_pigmentation	0.80578967
97	MP0003938_abnormal_ear_development	0.79759881
98	MP0005085_abnormal_gallbladder_physiolo	0.74188022
99	MP0005394_taste/olfaction_phenotype	0.73532182
100	MP0005499_abnormal_olfactory_system	0.73532182

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.59052070
2	Pancreatic cysts (HP:0001737)	4.15790201
3	Pancreatic fibrosis (HP:0100732)	4.06477054
4	Abnormality of midbrain morphology (HP:0002418)	4.06451412
5	Molar tooth sign on MRI (HP:0002419)	4.06451412
6	True hermaphroditism (HP:0010459)	3.91825646
7	Nephronophthisis (HP:0000090)	3.65170977
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.54141916
9	Hyperventilation (HP:0002883)	3.35343204
10	Abnormality of the renal cortex (HP:0011035)	3.28374179
11	Type II lissencephaly (HP:0007260)	3.27562464
12	Abnormality of the renal medulla (HP:0100957)	3.22665524
13	Attenuation of retinal blood vessels (HP:0007843)	2.98661149
14	Chronic hepatic failure (HP:0100626)	2.93886081
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.89065856
16	Abolished electroretinogram (ERG) (HP:0000550)	2.82289382
17	Renal cortical cysts (HP:0000803)	2.78581694
18	Mitochondrial inheritance (HP:0001427)	2.77703915
19	Congenital, generalized hypertrichosis (HP:0004540)	2.75461428
20	Cystic liver disease (HP:0006706)	2.74602870
21	Medial flaring of the eyebrow (HP:0010747)	2.60962962
22	Sclerocornea (HP:0000647)	2.55038078
23	Abnormality of the pons (HP:0007361)	2.53743515
24	Increased CSF lactate (HP:0002490)	2.53223749
25	Acute necrotizing encephalopathy (HP:0006965)	2.52585991
26	Hypoplasia of the pons (HP:0012110)	2.50799454
27	Hepatocellular necrosis (HP:0001404)	2.48287769
28	Hepatic necrosis (HP:0002605)	2.47827376
29	Anencephaly (HP:0002323)	2.46246655
30	Concave nail (HP:0001598)	2.40128849
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39587880
32	Increased corneal curvature (HP:0100692)	2.37203355
33	Keratoconus (HP:0000563)	2.37203355
34	Pendular nystagmus (HP:0012043)	2.37165239
35	Abnormality of the labia minora (HP:0012880)	2.33836474
36	Abnormal biliary tract physiology (HP:0012439)	2.31202816
37	Bile duct proliferation (HP:0001408)	2.31202816
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31099025
39	3-Methylglutaconic aciduria (HP:0003535)	2.28685971
40	Broad-based gait (HP:0002136)	2.26993552
41	Tubular atrophy (HP:0000092)	2.25790059
42	Absent/shortened dynein arms (HP:0200106)	2.25495846
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25495846
44	Optic disc pallor (HP:0000543)	2.22319861
45	Optic nerve hypoplasia (HP:0000609)	2.20034424
46	Lipid accumulation in hepatocytes (HP:0006561)	2.18823838
47	Abnormal drinking behavior (HP:0030082)	2.18561933
48	Polydipsia (HP:0001959)	2.18561933
49	Progressive macrocephaly (HP:0004481)	2.15379184
50	Abnormality of macular pigmentation (HP:0008002)	2.15081612
51	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.13561052
52	Hypoplasia of the fovea (HP:0007750)	2.13561052
53	Lissencephaly (HP:0001339)	2.12723181
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.12558695
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12558695
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11125791
57	Acute encephalopathy (HP:0006846)	2.10826221
58	Congenital hepatic fibrosis (HP:0002612)	2.09222682
59	Gait imbalance (HP:0002141)	2.08683929
60	Decreased central vision (HP:0007663)	2.06988123
61	Progressive cerebellar ataxia (HP:0002073)	2.05833183
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05806386
63	Furrowed tongue (HP:0000221)	2.03408562
64	Oligodactyly (hands) (HP:0001180)	2.03079167
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02304920
66	Abnormality of alanine metabolism (HP:0010916)	2.02304920
67	Hyperalaninemia (HP:0003348)	2.02304920
68	Nephrogenic diabetes insipidus (HP:0009806)	2.01769423
69	Increased hepatocellular lipid droplets (HP:0006565)	2.01756699
70	Constricted visual fields (HP:0001133)	2.00325853
71	Cerebellar dysplasia (HP:0007033)	1.99866083
72	Protruding tongue (HP:0010808)	1.98538558
73	Postaxial foot polydactyly (HP:0001830)	1.98105731
74	Large for gestational age (HP:0001520)	1.96891234
75	Bony spicule pigmentary retinopathy (HP:0007737)	1.96041712
76	Pachygyria (HP:0001302)	1.95806783
77	Methylmalonic acidemia (HP:0002912)	1.95767746
78	Congenital primary aphakia (HP:0007707)	1.95153259
79	Fair hair (HP:0002286)	1.94885694
80	Inability to walk (HP:0002540)	1.93410653
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92489800
82	Limb dystonia (HP:0002451)	1.92315964
83	Colon cancer (HP:0003003)	1.91788779
84	Methylmalonic aciduria (HP:0012120)	1.91422859
85	Hyperglycinuria (HP:0003108)	1.90686516
86	Rib fusion (HP:0000902)	1.89385517
87	Focal motor seizures (HP:0011153)	1.87189596
88	Septo-optic dysplasia (HP:0100842)	1.87077352
89	Male pseudohermaphroditism (HP:0000037)	1.87064446
90	Abnormality of the fovea (HP:0000493)	1.86731902
91	Febrile seizures (HP:0002373)	1.85281573
92	Occipital encephalocele (HP:0002085)	1.84076359
93	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78919200
94	Polyuria (HP:0000103)	1.78304121
95	Decreased circulating renin level (HP:0003351)	1.77819337
96	Tachypnea (HP:0002789)	1.77721980
97	Genital tract atresia (HP:0001827)	1.75427232
98	Patellar aplasia (HP:0006443)	1.75037385
99	Absent speech (HP:0001344)	1.75001973
100	Retinal dysplasia (HP:0007973)	1.74569734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.13352611
2	MAP4K2	3.46487140
3	BMPR1B	3.29019997
4	WNK4	3.05281872
5	ADRBK2	3.03560447
6	TLK1	2.82022395
7	CASK	2.73067880
8	WNK3	2.62826927
9	NME1	2.50780655
10	GRK1	2.49639964
11	PINK1	2.31396592
12	NUAK1	2.23618952
13	INSRR	2.19558094
14	VRK2	1.93710641
15	ZAK	1.92630259
16	TXK	1.83414224
17	MAPK13	1.76732416
18	TAOK3	1.63496764
19	STK39	1.60985629
20	DYRK2	1.50704115
21	BCKDK	1.49433229
22	OXSR1	1.47611946
23	DAPK2	1.46512333
24	MAP3K4	1.43056450
25	MARK1	1.36167772
26	CAMKK2	1.34564568
27	VRK1	1.33823286
28	TNIK	1.28411861
29	CSNK1G2	1.17258284
30	CSNK1G3	1.15128968
31	CDK19	1.12361266
32	MAP2K7	1.12265153
33	ADRBK1	1.12120446
34	PRKCG	1.09885280
35	CSNK1G1	1.08471009
36	PIK3CA	1.06070863
37	NTRK3	1.03224941
38	KIT	0.99345170
39	PNCK	0.98644640
40	TIE1	0.96884230
41	PRKCE	0.96585046
42	PAK3	0.92727625
43	MKNK2	0.90044355
44	STK16	0.89713538
45	PRKCQ	0.86625393
46	TYRO3	0.85681658
47	TGFBR1	0.83183999
48	EPHA4	0.82195501
49	FGFR2	0.79231445
50	MAPK15	0.78567101
51	MUSK	0.78037925
52	CSNK1A1L	0.76042688
53	ACVR1B	0.74938663
54	BCR	0.73305752
55	TEC	0.72540811
56	NTRK2	0.71796950
57	PRKCI	0.68744914
58	BRSK2	0.66943611
59	MAP2K6	0.66570601
60	LIMK1	0.63240965
61	STK38L	0.61962205
62	ITK	0.61870209
63	CAMK1	0.59824538
64	PLK2	0.59686764
65	CSNK1A1	0.58660629
66	PRKACA	0.56103925
67	IKBKB	0.52208796
68	PKN1	0.46942154
69	PHKG2	0.46861524
70	PHKG1	0.46861524
71	PLK4	0.46436609
72	RPS6KA5	0.44849390
73	SYK	0.44730153
74	WEE1	0.44392878
75	PRKCH	0.43432026
76	CAMK2A	0.42464142
77	PRKCZ	0.42405473
78	MAPKAPK3	0.40741649
79	PRKCA	0.39262272
80	OBSCN	0.38193978
81	DYRK3	0.37443482
82	MAPKAPK5	0.35616106
83	PLK3	0.35515353
84	CDK8	0.34078490
85	PTK2B	0.33271746
86	IKBKE	0.32977292
87	CAMKK1	0.32835309
88	MKNK1	0.32591545
89	PRKG1	0.32093584
90	NLK	0.31849769
91	STK3	0.29331036
92	WNK1	0.28995776
93	CHEK2	0.28892471
94	STK11	0.28854841
95	CSNK1D	0.28794901
96	PIK3CG	0.28618457
97	GRK5	0.27657643
98	GRK7	0.27317952
99	PRKACB	0.25478412
100	PASK	0.24442873

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15741226
2	Phototransduction_Homo sapiens_hsa04744	2.85775382
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.55365562
4	Parkinsons disease_Homo sapiens_hsa05012	2.51424798
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40998039
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39542858
7	Butanoate metabolism_Homo sapiens_hsa00650	2.35395121
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.27151514
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.17532026
10	Protein export_Homo sapiens_hsa03060	2.10814668
11	Ribosome_Homo sapiens_hsa03010	2.09716835
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97594965
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96450485
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86420066
15	Nicotine addiction_Homo sapiens_hsa05033	1.85374135
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.81698217
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76390395
18	Huntingtons disease_Homo sapiens_hsa05016	1.74520369
19	Homologous recombination_Homo sapiens_hsa03440	1.72261310
20	Alzheimers disease_Homo sapiens_hsa05010	1.70703701
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.66806487
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.63328218
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63168366
24	Caffeine metabolism_Homo sapiens_hsa00232	1.62476987
25	RNA polymerase_Homo sapiens_hsa03020	1.59799438
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.50271167
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.49007334
28	Proteasome_Homo sapiens_hsa03050	1.46415542
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40201063
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.30624023
31	Propanoate metabolism_Homo sapiens_hsa00640	1.29962284
32	Taste transduction_Homo sapiens_hsa04742	1.28970417
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23966711
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21701099
35	Olfactory transduction_Homo sapiens_hsa04740	1.20481715
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17603429
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.17005453
38	Morphine addiction_Homo sapiens_hsa05032	1.14634436
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11898609
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10962780
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09662931
42	Basal transcription factors_Homo sapiens_hsa03022	1.07130099
43	Retinol metabolism_Homo sapiens_hsa00830	1.07030887
44	Sulfur relay system_Homo sapiens_hsa04122	1.06694991
45	Asthma_Homo sapiens_hsa05310	1.04273456
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01526266
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01184500
48	One carbon pool by folate_Homo sapiens_hsa00670	1.00447889
49	RNA degradation_Homo sapiens_hsa03018	0.99506744
50	Peroxisome_Homo sapiens_hsa04146	0.97911259
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97764364
52	Serotonergic synapse_Homo sapiens_hsa04726	0.97238159
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93604337
54	ABC transporters_Homo sapiens_hsa02010	0.91572323
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90742259
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.86807480
57	GABAergic synapse_Homo sapiens_hsa04727	0.85093107
58	Circadian entrainment_Homo sapiens_hsa04713	0.82641308
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80374626
60	Folate biosynthesis_Homo sapiens_hsa00790	0.79369755
61	Insulin secretion_Homo sapiens_hsa04911	0.76537708
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75923298
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.73224499
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.72494894
65	Cocaine addiction_Homo sapiens_hsa05030	0.71968413
66	Purine metabolism_Homo sapiens_hsa00230	0.69379014
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.69136718
68	Salivary secretion_Homo sapiens_hsa04970	0.67523175
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64701582
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63942976
71	Metabolic pathways_Homo sapiens_hsa01100	0.63828541
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62045608
73	Fatty acid degradation_Homo sapiens_hsa00071	0.61509182
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60538863
75	Histidine metabolism_Homo sapiens_hsa00340	0.58249582
76	Circadian rhythm_Homo sapiens_hsa04710	0.56906353
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56556553
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.54875562
79	Mineral absorption_Homo sapiens_hsa04978	0.53952591
80	Allograft rejection_Homo sapiens_hsa05330	0.53045466
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52266891
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52018019
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51339564
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50937991
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49291704
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48623930
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.48291835
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.47847299
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.47630650
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.42788732
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42784552
92	Sulfur metabolism_Homo sapiens_hsa00920	0.42048495
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41996805
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41318839
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.41212311
96	Amphetamine addiction_Homo sapiens_hsa05031	0.40606480
97	Mismatch repair_Homo sapiens_hsa03430	0.39767302
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38860827
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.38459986
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.37768711

CHIAP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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