CHIC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)4.87093294
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58548289
3N-acetylneuraminate metabolic process (GO:0006054)4.53418766
4positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.41038984
5neutrophil mediated immunity (GO:0002446)4.40524525
6regulation of MHC class II biosynthetic process (GO:0045346)4.29627489
7DNA deamination (GO:0045006)4.17414979
8amino sugar catabolic process (GO:0046348)4.02406833
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.95831597
10regulation of chemokine biosynthetic process (GO:0045073)3.79617883
11protoporphyrinogen IX metabolic process (GO:0046501)3.79398063
12centriole replication (GO:0007099)3.71814634
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65993601
14negative regulation of cell killing (GO:0031342)3.65993601
15interferon-gamma production (GO:0032609)3.62432235
16base-excision repair, AP site formation (GO:0006285)3.58083707
17positive regulation of histone deacetylation (GO:0031065)3.52483070
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45268257
19regulation of B cell receptor signaling pathway (GO:0050855)3.45150891
20myeloid leukocyte mediated immunity (GO:0002444)3.44794036
21positive regulation of interleukin-8 secretion (GO:2000484)3.37940142
22platelet dense granule organization (GO:0060155)3.35235307
23purine deoxyribonucleotide catabolic process (GO:0009155)3.35188792
24regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.33330404
25modulation of growth of symbiont involved in interaction with host (GO:0044144)3.32170126
26regulation of growth of symbiont in host (GO:0044126)3.32170126
27negative regulation of growth of symbiont in host (GO:0044130)3.32170126
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.32170126
29response to peptidoglycan (GO:0032494)3.28557822
30CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.23482341
31leukocyte aggregation (GO:0070486)3.17975248
32neutrophil activation involved in immune response (GO:0002283)3.17166058
33production of molecular mediator involved in inflammatory response (GO:0002532)3.16945801
34neural tube formation (GO:0001841)3.14105678
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13406527
36cytidine deamination (GO:0009972)3.11906160
37cytidine metabolic process (GO:0046087)3.11906160
38cytidine catabolic process (GO:0006216)3.11906160
39positive regulation of gamma-delta T cell activation (GO:0046645)3.11047404
40CD4-positive, alpha-beta T cell activation (GO:0035710)3.06449505
41positive regulation by symbiont of host defense response (GO:0052509)3.05778720
42modulation by symbiont of host defense response (GO:0052031)3.05778720
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05778720
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05778720
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.05778720
46modulation by symbiont of host immune response (GO:0052553)3.05778720
47positive regulation of protein deacetylation (GO:0090312)3.05518037
48regulation of regulatory T cell differentiation (GO:0045589)3.01410540
49cellular response to interleukin-15 (GO:0071350)2.98629565
50response to muramyl dipeptide (GO:0032495)2.98402510
51microglial cell activation (GO:0001774)2.94061407
52macrophage activation (GO:0042116)2.93949129
53reactive oxygen species biosynthetic process (GO:1903409)2.93514279
54NIK/NF-kappaB signaling (GO:0038061)2.93292512
55immunoglobulin mediated immune response (GO:0016064)2.92053436
56macrophage chemotaxis (GO:0048246)2.91306396
57negative regulation of execution phase of apoptosis (GO:1900118)2.88372864
58pyrimidine ribonucleoside catabolic process (GO:0046133)2.84819690
59energy homeostasis (GO:0097009)2.84765131
60killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.84208380
61disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.84208380
62superoxide anion generation (GO:0042554)2.83942031
63positive regulation of prostaglandin secretion (GO:0032308)2.82854208
64protein deneddylation (GO:0000338)2.78938484
65positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77250863
66heme biosynthetic process (GO:0006783)2.75580726
67negative regulation of interleukin-2 production (GO:0032703)2.75222620
68regulation of interferon-beta biosynthetic process (GO:0045357)2.75056806
69defense response to fungus (GO:0050832)2.74501982
70regulation of T cell mediated cytotoxicity (GO:0001914)2.72463463
71regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.71923762
72regulation of necroptotic process (GO:0060544)2.70139507
73T cell migration (GO:0072678)2.69892239
74cellular extravasation (GO:0045123)2.68784716
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.65162642
76negative regulation of phagocytosis (GO:0050765)2.65004631
77macrophage activation involved in immune response (GO:0002281)2.63945545
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63445823
79cytokinetic process (GO:0032506)2.63079105
80negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62641727
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62605422
82N-acetylglucosamine metabolic process (GO:0006044)2.62331587
83negative regulation of T cell mediated immunity (GO:0002710)2.61648712
84response to fungus (GO:0009620)2.60713823
85positive regulation of interferon-alpha production (GO:0032727)2.60432338
86positive regulation of macrophage differentiation (GO:0045651)2.60227121
87negative regulation of interleukin-12 production (GO:0032695)2.59399274
88centriole assembly (GO:0098534)2.58013624
89definitive hemopoiesis (GO:0060216)2.57903894
90I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.57575410
91ribosomal small subunit assembly (GO:0000028)2.56991870
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56231111
93negative regulation of T-helper cell differentiation (GO:0045623)2.56231111
94positive regulation of interleukin-1 beta production (GO:0032731)2.55479205
95alpha-beta T cell differentiation (GO:0046632)2.54449171
96regulation of interleukin-8 secretion (GO:2000482)2.52907295
97negative regulation of myeloid cell apoptotic process (GO:0033033)2.52153840
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51851470
99regulation of interferon-alpha production (GO:0032647)2.51675458
100detection of other organism (GO:0098543)2.51307109
101neutrophil activation (GO:0042119)2.50911413
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50629107
103cellular response to zinc ion (GO:0071294)2.49620993
104defense response to protozoan (GO:0042832)2.49481127
105leukocyte degranulation (GO:0043299)2.49453110
106antigen processing and presentation of endogenous antigen (GO:0019883)2.49166024
107response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48884674
108response to host immune response (GO:0052572)2.48884674
109positive regulation of B cell differentiation (GO:0045579)2.48628597
110response to type I interferon (GO:0034340)2.47814746
111purinergic nucleotide receptor signaling pathway (GO:0035590)2.47727067
112cellular response to type I interferon (GO:0071357)2.47481652
113type I interferon signaling pathway (GO:0060337)2.47481652
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47262955
115positive regulation of DNA recombination (GO:0045911)2.47225775
116alpha-beta T cell activation (GO:0046631)2.46656684
117negative regulation of nitric oxide biosynthetic process (GO:0045019)2.46336937
118response to interleukin-15 (GO:0070672)2.46008037
119negative regulation of granulocyte differentiation (GO:0030853)2.45923057
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.45255190
121intracellular pH reduction (GO:0051452)2.45032251
122granulocyte activation (GO:0036230)2.44933562
123lymphocyte chemotaxis (GO:0048247)2.44508959
124response to protozoan (GO:0001562)2.43734849
125regulation of prostaglandin secretion (GO:0032306)2.43715214
126regulation of chronic inflammatory response (GO:0002676)2.43005003
127germinal center formation (GO:0002467)2.42869475
128hepatocyte apoptotic process (GO:0097284)2.42623136
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41992876
130positive regulation of interleukin-1 production (GO:0032732)2.40592969
131tolerance induction (GO:0002507)2.39192958
132myeloid leukocyte activation (GO:0002274)2.38731138
133natural killer cell activation involved in immune response (GO:0002323)2.38613444
134tyrosine phosphorylation of STAT protein (GO:0007260)2.37044540
135signal peptide processing (GO:0006465)2.36357061
136positive regulation of mast cell activation (GO:0033005)2.35790747
137T-helper 1 type immune response (GO:0042088)2.35481894
138interferon-gamma-mediated signaling pathway (GO:0060333)2.35144613
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34420161
140response to host (GO:0075136)2.34420161
141response to host defenses (GO:0052200)2.34420161
142regulation of mast cell activation (GO:0033003)2.34313045
143sequestering of actin monomers (GO:0042989)2.32244377
144regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.31812333
145positive regulation of mast cell degranulation (GO:0043306)2.31071708
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.31071708
147B cell mediated immunity (GO:0019724)2.30800911
148hydrogen peroxide biosynthetic process (GO:0050665)2.29741833
149myeloid dendritic cell activation (GO:0001773)2.29727043
150regulation of mast cell degranulation (GO:0043304)2.29006429
151regulation of B cell differentiation (GO:0045577)2.28752309
152myeloid cell activation involved in immune response (GO:0002275)2.28076879
153positive regulation of isotype switching (GO:0045830)2.26603198
154regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26435326
155negative regulation of viral genome replication (GO:0045071)2.24190989
156negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.23988417
157positive regulation of chemokine biosynthetic process (GO:0045080)2.23287707
158positive regulation of interleukin-1 secretion (GO:0050716)2.22931590
159regulation of interleukin-8 biosynthetic process (GO:0045414)2.22672259
160mature B cell differentiation (GO:0002335)2.21950001
161regulation of RIG-I signaling pathway (GO:0039535)2.21939695
162natural killer cell mediated immunity (GO:0002228)2.21724716
163natural killer cell mediated cytotoxicity (GO:0042267)2.21724716
164positive regulation of alpha-beta T cell proliferation (GO:0046641)2.21363187
165positive regulation of B cell mediated immunity (GO:0002714)2.20744979
166positive regulation of immunoglobulin mediated immune response (GO:0002891)2.20744979
167negative regulation of mast cell activation (GO:0033004)2.20544224
168dendritic cell migration (GO:0036336)2.20186467
169regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.20054211
170negative regulation of necroptotic process (GO:0060546)2.19266119
171respiratory burst (GO:0045730)2.18957918
172regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.18615538
173dendritic cell chemotaxis (GO:0002407)2.17759691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.32750151
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.99821288
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78700556
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.75269969
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72485034
6E2F7_22180533_ChIP-Seq_HELA_Human3.45207235
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.26530617
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15713259
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.12049182
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10973597
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10837526
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02846797
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.87740343
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.80949597
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68423323
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65571452
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59280691
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55472332
19SCL_19346495_ChIP-Seq_HPC-7_Human2.42594299
20GATA1_22025678_ChIP-Seq_K562_Human2.37029238
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35014651
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32051295
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30981322
24MYB_26560356_Chip-Seq_TH2_Human2.23670036
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22222496
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20440646
27SPI1_23547873_ChIP-Seq_NB4_Human2.18790398
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06689156
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.02989821
30RUNX_20019798_ChIP-Seq_JUKART_Human1.99765937
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.98852650
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98516375
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98108764
34MYB_26560356_Chip-Seq_TH1_Human1.94525581
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81141083
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77088084
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73624639
38PU_27001747_Chip-Seq_BMDM_Mouse1.70509702
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67561066
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.62453199
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.61940293
42VDR_24763502_ChIP-Seq_THP-1_Human1.60311229
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58816150
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52654079
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52579902
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.51293868
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49883142
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49685342
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49065200
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45566986
51ZNF274_21170338_ChIP-Seq_K562_Hela1.45157291
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43202973
53* MAF_26560356_Chip-Seq_TH1_Human1.41040725
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.40186892
55ER_23166858_ChIP-Seq_MCF-7_Human1.39610226
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39523049
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37601198
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37477504
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36034785
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34804651
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32553016
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30307508
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30126868
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28435800
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27732917
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27384263
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26803425
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26029259
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24541429
70VDR_24787735_ChIP-Seq_THP-1_Human1.24436413
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23564502
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22226030
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20855473
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18306744
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16409272
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15617084
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.15219205
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14818177
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13827066
80* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13680218
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12434324
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11933892
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11350568
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.11280521
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11133366
86GATA3_27048872_Chip-Seq_THYMUS_Human1.10461946
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.09992097
88FOXP3_21729870_ChIP-Seq_TREG_Human1.08005562
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07834310
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07584618
91GATA3_26560356_Chip-Seq_TH1_Human1.07097479
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.07062464
93UTX_26944678_Chip-Seq_JUKART_Human1.06882683
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06499390
95AR_20517297_ChIP-Seq_VCAP_Human1.06021710
96* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05830694
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05418992
98AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04516339
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03800525
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03492185
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02551990
102TCF7_22412390_ChIP-Seq_EML_Mouse1.02409284
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01654087
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01008379
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00836009
106IRF1_19129219_ChIP-ChIP_H3396_Human1.00343843
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99994189
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99994189
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99086177
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.99086177
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98291638
112VDR_21846776_ChIP-Seq_THP-1_Human0.97540827
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96942888
114BCAT_22108803_ChIP-Seq_LS180_Human0.96320645
115FOXM1_23109430_ChIP-Seq_U2OS_Human0.95388281
116MYC_22102868_ChIP-Seq_BL_Human0.94586297
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93911745
118BCL6_27268052_Chip-Seq_Bcells_Human0.92921446
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91726090
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.91721712
121SPI1_23127762_ChIP-Seq_K562_Human0.91138581
122NANOG_19829295_ChIP-Seq_ESCs_Human0.91127724
123SOX2_19829295_ChIP-Seq_ESCs_Human0.91127724
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89633145
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89592075
126TP53_22573176_ChIP-Seq_HFKS_Human0.89456768
127ERG_20517297_ChIP-Seq_VCAP_Human0.89424617
128TFEB_21752829_ChIP-Seq_HELA_Human0.89133842
129IGF1R_20145208_ChIP-Seq_DFB_Human0.88718245
130* VDR_23849224_ChIP-Seq_CD4+_Human0.88381326
131* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87838550
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86632461
133CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85604883
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85507338
135* GATA3_26560356_Chip-Seq_TH2_Human0.85430603
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82024537
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81521123
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80559483
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.77926076
140MAF_26560356_Chip-Seq_TH2_Human0.77707370
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77577237
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.77575058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.09343140
2MP0001835_abnormal_antigen_presentation3.50803251
3MP0003724_increased_susceptibility_to3.37445267
4MP0009785_altered_susceptibility_to2.85325966
5MP0005671_abnormal_response_to2.76266951
6MP0002148_abnormal_hypersensitivity_rea2.62032205
7MP0003436_decreased_susceptibility_to2.51853142
8MP0005000_abnormal_immune_tolerance2.44669211
9MP0003763_abnormal_thymus_physiology2.30258613
10MP0005025_abnormal_response_to2.20721727
11MP0000685_abnormal_immune_system2.20377396
12MP0001800_abnormal_humoral_immune2.19808819
13MP0002452_abnormal_antigen_presenting2.18916638
14MP0002419_abnormal_innate_immunity2.10477738
15MP0002723_abnormal_immune_serum2.06363103
16MP0002009_preneoplasia2.05964684
17MP0005387_immune_system_phenotype2.05028110
18MP0001790_abnormal_immune_system2.05028110
19MP0003828_pulmonary_edema2.04714745
20MP0002420_abnormal_adaptive_immunity2.01890293
21MP0001819_abnormal_immune_cell2.01709832
22MP0002132_abnormal_respiratory_system1.99920985
23MP0002405_respiratory_system_inflammati1.98569105
24MP0008961_abnormal_basal_metabolism1.98239083
25MP0003303_peritoneal_inflammation1.97183561
26MP0009333_abnormal_splenocyte_physiolog1.90621146
27MP0006082_CNS_inflammation1.85396821
28MP0003252_abnormal_bile_duct1.83818552
29MP0002166_altered_tumor_susceptibility1.83226443
30MP0005174_abnormal_tail_pigmentation1.81078634
31MP0005365_abnormal_bile_salt1.76868088
32MP0002006_tumorigenesis1.70917286
33MP0003191_abnormal_cellular_cholesterol1.67687534
34MP0003941_abnormal_skin_development1.66995256
35MP0002398_abnormal_bone_marrow1.64348416
36MP0000465_gastrointestinal_hemorrhage1.62997678
37MP0003195_calcinosis1.61277971
38MP0000716_abnormal_immune_system1.54117132
39MP0001853_heart_inflammation1.52761927
40MP0010155_abnormal_intestine_physiology1.51675957
41MP0005451_abnormal_body_composition1.49669008
42MP0004808_abnormal_hematopoietic_stem1.48839092
43MP0000858_altered_metastatic_potential1.47314545
44MP0004947_skin_inflammation1.46743878
45MP0004043_abnormal_pH_regulation1.44312040
46MP0005464_abnormal_platelet_physiology1.43709700
47MP0000015_abnormal_ear_pigmentation1.42380429
48MP0000490_abnormal_crypts_of1.41503345
49MP0002396_abnormal_hematopoietic_system1.40837963
50MP0001845_abnormal_inflammatory_respons1.38429881
51MP0005310_abnormal_salivary_gland1.38222676
52MP0005075_abnormal_melanosome_morpholog1.37374358
53MP0005257_abnormal_intraocular_pressure1.37310530
54MP0009764_decreased_sensitivity_to1.36882432
55MP0008007_abnormal_cellular_replicative1.34783374
56MP0001873_stomach_inflammation1.34213054
57MP0002722_abnormal_immune_system1.33990370
58MP0001533_abnormal_skeleton_physiology1.32351581
59MP0000689_abnormal_spleen_morphology1.32263590
60MP0005084_abnormal_gallbladder_morpholo1.30062666
61MP0002138_abnormal_hepatobiliary_system1.29235367
62MP0001879_abnormal_lymphatic_vessel1.28341951
63MP0000372_irregular_coat_pigmentation1.27882508
64MP0002429_abnormal_blood_cell1.26731336
65MP0001542_abnormal_bone_strength1.26018504
66MP0005670_abnormal_white_adipose1.22367348
67MP0000703_abnormal_thymus_morphology1.20106379
68MP0005085_abnormal_gallbladder_physiolo1.19002104
69MP0001851_eye_inflammation1.18859272
70MP0004381_abnormal_hair_follicle1.18249943
71MP0004510_myositis1.16640318
72MP0003656_abnormal_erythrocyte_physiolo1.16100760
73MP0003448_altered_tumor_morphology1.15817638
74MP0008057_abnormal_DNA_replication1.12926624
75MP0001545_abnormal_hematopoietic_system1.11154742
76MP0005397_hematopoietic_system_phenotyp1.11154742
77MP0003806_abnormal_nucleotide_metabolis1.10407081
78MP0003300_gastrointestinal_ulcer1.09696598
79MP0009379_abnormal_foot_pigmentation1.09064105
80MP0009763_increased_sensitivity_to1.06015076
81MP0000343_altered_response_to1.05709389
82MP0002254_reproductive_system_inflammat1.04514087
83MP0005390_skeleton_phenotype1.03751086
84MP0002928_abnormal_bile_duct1.01818563
85MP0002095_abnormal_skin_pigmentation1.01625726
86MP0002933_joint_inflammation1.00367548
87MP0008469_abnormal_protein_level0.99610941
88MP0000516_abnormal_urinary_system0.99609478
89MP0005367_renal/urinary_system_phenotyp0.99609478
90MP0002277_abnormal_respiratory_mucosa0.98910629
91MP0005076_abnormal_cell_differentiation0.98351034
92MP0008872_abnormal_physiological_respon0.98053744
93MP0000569_abnormal_digit_pigmentation0.97784171
94MP0005167_abnormal_blood-brain_barrier0.97625292
95MP0003866_abnormal_defecation0.95755842
96MP0009278_abnormal_bone_marrow0.94998213
97MP0010386_abnormal_urinary_bladder0.93683924
98MP0008004_abnormal_stomach_pH0.93324165
99MP0003693_abnormal_embryo_hatching0.92624862
100MP0002998_abnormal_bone_remodeling0.89864946
101MP0006292_abnormal_olfactory_placode0.88676056
102MP0004142_abnormal_muscle_tone0.87191134
103MP0009765_abnormal_xenobiotic_induced0.84973157
104MP0006054_spinal_hemorrhage0.84686993
105MP0006072_abnormal_retinal_apoptosis0.83416385
106MP0000767_abnormal_smooth_muscle0.82943219
107MP0008058_abnormal_DNA_repair0.82640570
108MP0003136_yellow_coat_color0.82042955
109MP0000249_abnormal_blood_vessel0.81221577
110MP0000678_abnormal_parathyroid_gland0.80747787
111MP0010094_abnormal_chromosome_stability0.80435016
112MP0005253_abnormal_eye_physiology0.78875552
113MP0002332_abnormal_exercise_endurance0.77896883
114MP0003075_altered_response_to0.77096059
115MP0004782_abnormal_surfactant_physiolog0.77069316
116MP0002877_abnormal_melanocyte_morpholog0.76933623
117MP0002693_abnormal_pancreas_physiology0.74121597
118MP0006036_abnormal_mitochondrial_physio0.73470878
119MP0000049_abnormal_middle_ear0.73453327
120MP0005248_abnormal_Harderian_gland0.73272793
121MP0003077_abnormal_cell_cycle0.72905502
122MP0003943_abnormal_hepatobiliary_system0.72407737
123MP0005166_decreased_susceptibility_to0.71417960
124MP0002019_abnormal_tumor_incidence0.71348349
125MP0003111_abnormal_nucleus_morphology0.70779401
126MP0003795_abnormal_bone_structure0.70086730
127MP0003453_abnormal_keratinocyte_physiol0.69349231
128MP0008877_abnormal_DNA_methylation0.68870547
129MP0001119_abnormal_female_reproductive0.68784779
130MP0001191_abnormal_skin_condition0.68221639
131MP0002177_abnormal_outer_ear0.67703189
132MP0001188_hyperpigmentation0.67313707
133MP0008875_abnormal_xenobiotic_pharmacok0.67162372
134MP0008873_increased_physiological_sensi0.66341836
135MP0009115_abnormal_fat_cell0.65595756
136MP0005164_abnormal_response_to0.64089506
137MP0009053_abnormal_anal_canal0.63047112
138MP0001216_abnormal_epidermal_layer0.62615634
139MP0003786_premature_aging0.62393871

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.50220948
2Eczematoid dermatitis (HP:0000976)4.33462280
3Myositis (HP:0100614)4.01783772
4Prostate neoplasm (HP:0100787)3.98605402
5Recurrent bacterial skin infections (HP:0005406)3.67118604
6Mediastinal lymphadenopathy (HP:0100721)3.59986142
7Orchitis (HP:0100796)3.51479170
8Elevated erythrocyte sedimentation rate (HP:0003565)3.48674319
9Retrobulbar optic neuritis (HP:0100654)3.30865905
10Optic neuritis (HP:0100653)3.30865905
11Obstructive lung disease (HP:0006536)3.18351767
12Chronic obstructive pulmonary disease (HP:0006510)3.18351767
13IgM deficiency (HP:0002850)3.17014521
14Abnormality of the prostate (HP:0008775)3.10750286
15Vacuolated lymphocytes (HP:0001922)3.00951688
16Stomatitis (HP:0010280)3.00870046
17Recurrent gram-negative bacterial infections (HP:0005420)2.99230918
18Meningitis (HP:0001287)2.94883179
19Recurrent fungal infections (HP:0002841)2.93763281
20Increased IgM level (HP:0003496)2.90427947
21Chest pain (HP:0100749)2.78412118
22Episodic fever (HP:0001954)2.75337166
23Recurrent cutaneous fungal infections (HP:0011370)2.70230125
24Chronic mucocutaneous candidiasis (HP:0002728)2.70230125
25Cheilitis (HP:0100825)2.68718250
26Recurrent bronchitis (HP:0002837)2.67927258
27Renal Fanconi syndrome (HP:0001994)2.65922842
28Vasculitis (HP:0002633)2.61965691
29Prolonged bleeding time (HP:0003010)2.56839271
30Increased intramyocellular lipid droplets (HP:0012240)2.53210485
31Granulocytopenia (HP:0001913)2.52139144
32Exertional dyspnea (HP:0002875)2.50807615
33Recurrent skin infections (HP:0001581)2.49577307
34Pulmonary infiltrates (HP:0002113)2.46139301
35Hypoproteinemia (HP:0003075)2.45330056
36Gingivitis (HP:0000230)2.39951117
37Abnormality of glycolipid metabolism (HP:0010969)2.39633596
38Abnormality of liposaccharide metabolism (HP:0010968)2.39633596
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.39633596
40Recurrent viral infections (HP:0004429)2.37585150
41Chronic diarrhea (HP:0002028)2.37267094
42Pulmonary fibrosis (HP:0002206)2.37221492
43Increased hepatocellular lipid droplets (HP:0006565)2.37072289
44Abnormality of the nasal septum (HP:0000419)2.34233357
45Abnormality of T cell physiology (HP:0011840)2.33132012
46Spinal cord lesions (HP:0100561)2.32833679
47Syringomyelia (HP:0003396)2.32833679
48Parakeratosis (HP:0001036)2.30778584
49IgG deficiency (HP:0004315)2.30245694
50Porencephaly (HP:0002132)2.28535989
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27827087
52Pustule (HP:0200039)2.26490230
53Arterial thrombosis (HP:0004420)2.25565911
54Abnormality of T cells (HP:0002843)2.25435204
55Medial flaring of the eyebrow (HP:0010747)2.23763994
56Leukocytosis (HP:0001974)2.19292024
57Hypergammaglobulinemia (HP:0010702)2.19291775
58Hemoptysis (HP:0002105)2.17777294
59Lipid accumulation in hepatocytes (HP:0006561)2.17602835
60Abnormality of macrophages (HP:0004311)2.17565609
61Reticulocytopenia (HP:0001896)2.17148336
62Gastrointestinal infarctions (HP:0005244)2.17144712
63Keratoconjunctivitis (HP:0001096)2.14880053
64Pulmonary embolism (HP:0002204)2.14681407
65Increased muscle lipid content (HP:0009058)2.14670455
66Hematochezia (HP:0002573)2.14479792
67Agammaglobulinemia (HP:0004432)2.12948395
68Chromsome breakage (HP:0040012)2.12234556
69Thyroiditis (HP:0100646)2.11197229
70Aplastic anemia (HP:0001915)2.08793712
71Epistaxis (HP:0000421)2.08621531
72Periodontitis (HP:0000704)2.07910122
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07578877
74Urticaria (HP:0001025)2.06373061
75Glomerulopathy (HP:0100820)2.06153565
76Reduced antithrombin III activity (HP:0001976)2.05798041
77Polyneuropathy (HP:0001271)2.03399588
78Lymphopenia (HP:0001888)2.02587280
79Constricted visual fields (HP:0001133)2.02338114
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02000709
81Inflammation of the large intestine (HP:0002037)2.01996903
82Cutaneous photosensitivity (HP:0000992)2.01860955
83Abnormal rod and cone electroretinograms (HP:0008323)2.01104346
84Recurrent sinusitis (HP:0011108)1.97999241
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97460149
86Hepatosplenomegaly (HP:0001433)1.97399373
87Abnormality of the pericardium (HP:0001697)1.97188394
88Impaired platelet aggregation (HP:0003540)1.96403895
89Abnormal platelet function (HP:0011869)1.96403895
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.96351856
91Mitochondrial inheritance (HP:0001427)1.96107969
92Abnormality of eosinophils (HP:0001879)1.95806615
93Adactyly (HP:0009776)1.95469390
94Cellulitis (HP:0100658)1.94995383
95Gangrene (HP:0100758)1.94772365
96Abnormality of the renal cortex (HP:0011035)1.94276259
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.94244531
98Petechiae (HP:0000967)1.92675973
99Abolished electroretinogram (ERG) (HP:0000550)1.91583894
100Panhypogammaglobulinemia (HP:0003139)1.90989580
101Chronic sinusitis (HP:0011109)1.90868179
102Autoimmune thrombocytopenia (HP:0001973)1.90068202
103Keratoconjunctivitis sicca (HP:0001097)1.89158936
104Attenuation of retinal blood vessels (HP:0007843)1.88717215
105Abnormality of the distal phalanges of the toes (HP:0010182)1.87548652
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87487469
107Bronchitis (HP:0012387)1.86474024
108Pancreatitis (HP:0001733)1.85642437
109Acute myeloid leukemia (HP:0004808)1.85622309
110IgA deficiency (HP:0002720)1.85484398
111Encephalitis (HP:0002383)1.84447988
112Recurrent pneumonia (HP:0006532)1.84165448
113Autoimmune hemolytic anemia (HP:0001890)1.83096833
114Keratitis (HP:0000491)1.82968107
115Abnormality of male internal genitalia (HP:0000022)1.82633673
116Abnormality of T cell number (HP:0011839)1.82323375
117Albinism (HP:0001022)1.82277147
118Combined immunodeficiency (HP:0005387)1.82267528
119Lymphoma (HP:0002665)1.80028778
120Lip pit (HP:0100267)1.79625993
121Pulmonary artery stenosis (HP:0004415)1.79033206
122Congenital, generalized hypertrichosis (HP:0004540)1.78938622
123T lymphocytopenia (HP:0005403)1.78501211
124Nasal polyposis (HP:0100582)1.77917192
125Failure to thrive in infancy (HP:0001531)1.77482739
126Intestinal atresia (HP:0011100)1.75960555
127Eosinophilia (HP:0001880)1.75243309
128Clubbing of toes (HP:0100760)1.74827180
129Severe combined immunodeficiency (HP:0004430)1.74725971
130Molar tooth sign on MRI (HP:0002419)1.73964531
131Abnormality of midbrain morphology (HP:0002418)1.73964531
132Metaphyseal dysplasia (HP:0100255)1.73872724
133Amyotrophic lateral sclerosis (HP:0007354)1.73440436
134Recurrent lower respiratory tract infections (HP:0002783)1.73328726
135Congenital primary aphakia (HP:0007707)1.72876690
136Neoplasm of the adrenal cortex (HP:0100641)1.72162495
137Gastrointestinal stroma tumor (HP:0100723)1.72004513
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.71891240
139Hypoplasia of the fovea (HP:0007750)1.71891240
140Hypothermia (HP:0002045)1.71419060
141Gastrointestinal inflammation (HP:0004386)1.71371376
142Osteomyelitis (HP:0002754)1.71156868
143Spontaneous hematomas (HP:0007420)1.70852002
144Gingival bleeding (HP:0000225)1.67608027
145Basal ganglia calcification (HP:0002135)1.66809875
146Anorexia (HP:0002039)1.66629566
147Abnormality of the pleura (HP:0002103)1.65628585
148Bronchiectasis (HP:0002110)1.65039037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.78415461
2TXK3.51777957
3MAP3K143.18907137
4CAMKK23.16722361
5NEK22.90457228
6TESK22.90373785
7ZAK2.41348009
8VRK22.39218911
9IRAK42.35876339
10TEC2.35850425
11IKBKE2.22005187
12BLK2.19769783
13JAK32.05544053
14TBK12.04195074
15NME22.01492035
16IKBKB2.00155328
17EPHA31.86261150
18MAP4K11.84571899
19KIT1.83998712
20NEK91.83366852
21MST1R1.81428002
22EIF2AK31.78332837
23PIM21.77092800
24NLK1.74655320
25CASK1.68982109
26MAP4K21.65412262
27DYRK31.63767489
28BMPR1B1.60226116
29TYK21.56873700
30GRK61.53096244
31YES11.51388394
32IRAK31.51062364
33PIM11.48701269
34CDK81.47028045
35ZAP701.46464110
36CHUK1.46196851
37MKNK21.45893067
38TGFBR11.45883796
39EIF2AK21.42943358
40RIPK41.42725090
41BTK1.37691634
42TGFBR21.31084871
43FRK1.25695016
44TAOK31.24735756
45MAP3K111.23791307
46MST41.22998181
47TAF11.21966368
48STK241.18806483
49ACVR1B1.17979905
50RPS6KA41.15944939
51CSK1.15901754
52CAMK1D1.15293540
53TNK21.14619839
54LIMK11.12595004
55PIK3CG1.09432804
56SRPK11.09058327
57PTK2B1.05017820
58MARK31.03627901
59GRK51.03253143
60BMPR21.02230151
61LYN1.01764769
62ERN11.01698343
63MAPK151.01111760
64SIK31.00731479
65VRK11.00655854
66CLK10.99976527
67MKNK10.99887736
68MATK0.99295049
69CSNK1G30.97857685
70LCK0.97217863
71SYK0.95977643
72IRAK10.93227165
73EPHB10.93183275
74CDK90.92219272
75CSNK1A1L0.90232499
76JAK10.90189008
77CDK30.89264660
78ITK0.86630419
79PDK20.84415172
80TAOK20.83775313
81CDK70.83502274
82GRK10.82989889
83CSNK1G10.80339992
84CDK120.78462972
85STK100.76241209
86PBK0.76196982
87LRRK20.75861892
88FGR0.74763651
89ERBB30.74126562
90KDR0.74036579
91DAPK10.73037786
92FLT30.72528736
93STK40.71098382
94FGFR30.68158836
95TRPM70.67560252
96MAP2K30.66131845
97BCKDK0.64459369
98MAP3K70.63246120
99ABL20.62924821
100MAP3K130.61553965
101ADRBK10.61373201
102FES0.60760317
103ADRBK20.60692856
104RPS6KA50.60556932
105CSNK1G20.60380735
106IRAK20.60232492
107MAP3K120.59639718
108MAP3K10.59031554
109CSF1R0.58579054
110HCK0.58179564
111GRK70.57881315
112PIK3CA0.57258618
113TLK10.56582436
114ATR0.55875089
115NUAK10.54616277
116MOS0.54263145
117HIPK20.53632653
118TRIM280.53063906
119MAP3K50.52675814
120STK30.50366401
121JAK20.48440621
122PRKCQ0.47241029
123MAPK110.47120361
124TIE10.46929237
125MUSK0.46862137
126INSRR0.46770423
127TESK10.43694094
128TNIK0.43448694
129WNK30.42821434
130CAMK1G0.42020059
131MAP2K20.41783230
132MAP3K30.40429495
133BCR0.39346222
134ABL10.38844092
135RPS6KA60.38696758
136AURKB0.37800485
137PLK20.36708565
138MAPKAPK20.35819357
139PRKD20.35688511
140TAOK10.35153315
141DYRK1B0.35092234
142MAP3K100.34130750

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.43309454
2Leishmaniasis_Homo sapiens_hsa051402.33040411
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16992852
4Primary immunodeficiency_Homo sapiens_hsa053402.13596955
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11110110
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.05720223
7Measles_Homo sapiens_hsa051621.98954509
8Graft-versus-host disease_Homo sapiens_hsa053321.97919074
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91916572
10Hematopoietic cell lineage_Homo sapiens_hsa046401.87770627
11Osteoclast differentiation_Homo sapiens_hsa043801.83820596
12Legionellosis_Homo sapiens_hsa051341.81982509
13Herpes simplex infection_Homo sapiens_hsa051681.79591544
14Allograft rejection_Homo sapiens_hsa053301.78437118
15Ribosome_Homo sapiens_hsa030101.70052736
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66515875
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66270569
18Malaria_Homo sapiens_hsa051441.63221677
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62585241
20TNF signaling pathway_Homo sapiens_hsa046681.58723783
21Asthma_Homo sapiens_hsa053101.56078315
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.48292056
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46749895
24Influenza A_Homo sapiens_hsa051641.46688355
25Antigen processing and presentation_Homo sapiens_hsa046121.46053635
26B cell receptor signaling pathway_Homo sapiens_hsa046621.44157288
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43459216
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43089022
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40523538
30Homologous recombination_Homo sapiens_hsa034401.34542832
31Tuberculosis_Homo sapiens_hsa051521.33491341
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33298675
33Toxoplasmosis_Homo sapiens_hsa051451.33030492
34Lysosome_Homo sapiens_hsa041421.32784401
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32758083
36Staphylococcus aureus infection_Homo sapiens_hsa051501.31817455
37T cell receptor signaling pathway_Homo sapiens_hsa046601.28138423
38p53 signaling pathway_Homo sapiens_hsa041151.27855569
39Protein export_Homo sapiens_hsa030601.26463171
40Regulation of autophagy_Homo sapiens_hsa041401.25310436
41Base excision repair_Homo sapiens_hsa034101.24435623
42Apoptosis_Homo sapiens_hsa042101.23631064
43Oxidative phosphorylation_Homo sapiens_hsa001901.21837228
44Rheumatoid arthritis_Homo sapiens_hsa053231.19832754
45Acute myeloid leukemia_Homo sapiens_hsa052211.17416573
46Pertussis_Homo sapiens_hsa051331.16454603
47Collecting duct acid secretion_Homo sapiens_hsa049661.15222457
48Basal transcription factors_Homo sapiens_hsa030221.14902867
49Hepatitis B_Homo sapiens_hsa051611.14322062
50Proteasome_Homo sapiens_hsa030501.13274239
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12566410
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11716308
53Other glycan degradation_Homo sapiens_hsa005111.09057669
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07776769
55Renin-angiotensin system_Homo sapiens_hsa046141.06728498
56Fanconi anemia pathway_Homo sapiens_hsa034601.06585182
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05751782
58Autoimmune thyroid disease_Homo sapiens_hsa053201.05113033
59Salmonella infection_Homo sapiens_hsa051321.04939982
60Caffeine metabolism_Homo sapiens_hsa002321.02324886
61DNA replication_Homo sapiens_hsa030301.02018731
62Spliceosome_Homo sapiens_hsa030400.99777496
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.99776847
64Sulfur metabolism_Homo sapiens_hsa009200.99223362
65Small cell lung cancer_Homo sapiens_hsa052220.89889413
66Phototransduction_Homo sapiens_hsa047440.89411526
67Chemokine signaling pathway_Homo sapiens_hsa040620.88546510
68Epstein-Barr virus infection_Homo sapiens_hsa051690.88169218
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87988327
70HTLV-I infection_Homo sapiens_hsa051660.87817847
71Viral myocarditis_Homo sapiens_hsa054160.87712432
72Hepatitis C_Homo sapiens_hsa051600.87334897
73Pancreatic cancer_Homo sapiens_hsa052120.87157704
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84348239
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84219159
76Platelet activation_Homo sapiens_hsa046110.83756093
77Peroxisome_Homo sapiens_hsa041460.83413171
78Parkinsons disease_Homo sapiens_hsa050120.82907465
79Folate biosynthesis_Homo sapiens_hsa007900.82298568
80Prostate cancer_Homo sapiens_hsa052150.80875299
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80707681
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79721462
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.79666484
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78037825
85Arachidonic acid metabolism_Homo sapiens_hsa005900.77602197
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77503465
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76502678
88Cell cycle_Homo sapiens_hsa041100.76109742
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75941555
90MicroRNAs in cancer_Homo sapiens_hsa052060.75259614
91Viral carcinogenesis_Homo sapiens_hsa052030.74423801
92Shigellosis_Homo sapiens_hsa051310.72904867
93Chronic myeloid leukemia_Homo sapiens_hsa052200.71942101
94Systemic lupus erythematosus_Homo sapiens_hsa053220.71628700
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69163672
96African trypanosomiasis_Homo sapiens_hsa051430.68665108
97Type I diabetes mellitus_Homo sapiens_hsa049400.64747867
98RNA polymerase_Homo sapiens_hsa030200.63046061
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62358161
100Linoleic acid metabolism_Homo sapiens_hsa005910.59181435
101Phagosome_Homo sapiens_hsa041450.58290198
102Pyrimidine metabolism_Homo sapiens_hsa002400.57826759
103TGF-beta signaling pathway_Homo sapiens_hsa043500.56617931
104Non-homologous end-joining_Homo sapiens_hsa034500.55311826
105Adherens junction_Homo sapiens_hsa045200.54929622
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54691647
107Ether lipid metabolism_Homo sapiens_hsa005650.54518008
108Sphingolipid metabolism_Homo sapiens_hsa006000.53832217
109Nucleotide excision repair_Homo sapiens_hsa034200.53299700
110Prolactin signaling pathway_Homo sapiens_hsa049170.53280294
111Thyroid cancer_Homo sapiens_hsa052160.52774017
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52444073
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52093611
114Fatty acid elongation_Homo sapiens_hsa000620.50475720
115Colorectal cancer_Homo sapiens_hsa052100.50152802
116RNA degradation_Homo sapiens_hsa030180.47727550
117Pathways in cancer_Homo sapiens_hsa052000.47176623
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46928520
119mRNA surveillance pathway_Homo sapiens_hsa030150.46644798
120FoxO signaling pathway_Homo sapiens_hsa040680.46019904
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45423833
122Melanoma_Homo sapiens_hsa052180.45107912
123Mismatch repair_Homo sapiens_hsa034300.44883024
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43483972
125Endometrial cancer_Homo sapiens_hsa052130.41751522
126Vibrio cholerae infection_Homo sapiens_hsa051100.40575830
127Vitamin digestion and absorption_Homo sapiens_hsa049770.40091071
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39604011
129Bladder cancer_Homo sapiens_hsa052190.39171185
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39037612
131Circadian rhythm_Homo sapiens_hsa047100.35937774
132Nitrogen metabolism_Homo sapiens_hsa009100.34399447

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