CHID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.39357128
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.15165769
3Golgi transport vesicle coating (GO:0048200)5.06216795
4COPI coating of Golgi vesicle (GO:0048205)5.06216795
5protein retention in ER lumen (GO:0006621)4.94341283
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84651098
7regulation of mitochondrial translation (GO:0070129)4.65669069
8signal peptide processing (GO:0006465)4.30181444
9ATP synthesis coupled proton transport (GO:0015986)4.27590689
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27590689
11protein maturation by protein folding (GO:0022417)4.11373828
12protein complex biogenesis (GO:0070271)4.05572062
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93475033
14respiratory electron transport chain (GO:0022904)3.91268215
15mitotic nuclear envelope reassembly (GO:0007084)3.88943907
16nuclear envelope reassembly (GO:0031468)3.88943907
17chaperone-mediated protein transport (GO:0072321)3.87771348
18proteasome assembly (GO:0043248)3.87117023
19electron transport chain (GO:0022900)3.85847817
20mitochondrial respiratory chain complex assembly (GO:0033108)3.72756845
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.72756446
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.65200454
23oxidative phosphorylation (GO:0006119)3.55040658
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49562370
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.49562370
26NADH dehydrogenase complex assembly (GO:0010257)3.49562370
27exocrine pancreas development (GO:0031017)3.42352542
28guanosine-containing compound biosynthetic process (GO:1901070)3.37956967
29protein targeting to mitochondrion (GO:0006626)3.36656926
30peptidyl-arginine omega-N-methylation (GO:0035247)3.33825038
31cullin deneddylation (GO:0010388)3.32434494
32cytochrome complex assembly (GO:0017004)3.30941756
33cerebellar Purkinje cell layer development (GO:0021680)3.29828382
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28905476
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28905476
36protein deneddylation (GO:0000338)3.24924238
37establishment of protein localization to mitochondrion (GO:0072655)3.22025111
38respiratory chain complex IV assembly (GO:0008535)3.21120812
39UTP biosynthetic process (GO:0006228)3.18999254
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16972898
41type B pancreatic cell proliferation (GO:0044342)3.14901761
42lipopolysaccharide biosynthetic process (GO:0009103)3.14273165
43L-phenylalanine catabolic process (GO:0006559)3.14007566
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.14007566
45heme biosynthetic process (GO:0006783)3.12868278
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12001740
47regulation of cellular amino acid metabolic process (GO:0006521)3.10841091
48COPII vesicle coating (GO:0048208)3.10452607
49proline biosynthetic process (GO:0006561)3.10126108
50protoporphyrinogen IX biosynthetic process (GO:0006782)3.09251198
51ER overload response (GO:0006983)3.08821385
52regulation of short-term neuronal synaptic plasticity (GO:0048172)3.08200214
53mannosylation (GO:0097502)3.07936386
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.06353413
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.06231585
56L-phenylalanine metabolic process (GO:0006558)3.06231585
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05991164
58positive regulation of TOR signaling (GO:0032008)3.05282495
59ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.05066076
60rRNA modification (GO:0000154)3.03884463
61establishment of integrated proviral latency (GO:0075713)3.03170072
62establishment of viral latency (GO:0019043)3.03160061
63iron-sulfur cluster assembly (GO:0016226)3.02269078
64metallo-sulfur cluster assembly (GO:0031163)3.02269078
65heme metabolic process (GO:0042168)3.01980516
66protein localization to mitochondrion (GO:0070585)2.98263481
67C-terminal protein lipidation (GO:0006501)2.96431571
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96172637
69negative regulation of ligase activity (GO:0051352)2.96172637
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95605895
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90511456
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89442578
73peptide hormone processing (GO:0016486)2.89384529
74UV protection (GO:0009650)2.87497848
75negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.87249428
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85522565
77termination of RNA polymerase III transcription (GO:0006386)2.85197613
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.85197613
79UTP metabolic process (GO:0046051)2.85054605
80base-excision repair, AP site formation (GO:0006285)2.85000103
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83722172
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82819192
83positive regulation of nuclease activity (GO:0032075)2.81412598
84deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78867762
85pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.78378313
86CTP metabolic process (GO:0046036)2.77492890
87CTP biosynthetic process (GO:0006241)2.77492890
88aldehyde catabolic process (GO:0046185)2.75214298
89pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.75209517
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74657649
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74657649
92pseudouridine synthesis (GO:0001522)2.74514823
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.73558954
94vocalization behavior (GO:0071625)2.73204153
95ATP biosynthetic process (GO:0006754)2.72777108
96GMP metabolic process (GO:0046037)2.71932515
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71532499
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71532499
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71532499
100inner mitochondrial membrane organization (GO:0007007)2.71531374
101histone arginine methylation (GO:0034969)2.69945764
102response to pheromone (GO:0019236)2.69753951
103protoporphyrinogen IX metabolic process (GO:0046501)2.67814692
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67589988
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66668960
106vesicle coating (GO:0006901)2.66660224
107synaptic vesicle exocytosis (GO:0016079)2.65341667
108ribosomal small subunit assembly (GO:0000028)2.64824250
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.64745143
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64745143
111female mating behavior (GO:0060180)2.64114902
112aerobic respiration (GO:0009060)2.61826086
113endoplasmic reticulum unfolded protein response (GO:0030968)2.60250575
114pentose-phosphate shunt (GO:0006098)2.59525859
115hydrogen peroxide catabolic process (GO:0042744)2.59416658
116signal transduction involved in cell cycle checkpoint (GO:0072395)2.59253159
117peptidyl-arginine methylation (GO:0018216)2.58943988
118energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.57840114
119ATP hydrolysis coupled proton transport (GO:0015991)2.57840114
120regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.57341094
121cellular response to unfolded protein (GO:0034620)2.57044710
122protein N-linked glycosylation via asparagine (GO:0018279)2.56922037
123intestinal cholesterol absorption (GO:0030299)2.55160069
124peptidyl-asparagine modification (GO:0018196)2.51105132
125endocrine pancreas development (GO:0031018)2.48306127
126cellular response to topologically incorrect protein (GO:0035967)2.46613981
127ER-nucleus signaling pathway (GO:0006984)2.46336923
128zinc ion transport (GO:0006829)2.44930050
129positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.42216862
130regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41869372
131regulation of nuclease activity (GO:0032069)2.41859727
132neurotransmitter secretion (GO:0007269)2.40201084
133aromatic amino acid family catabolic process (GO:0009074)2.38906102
134digestion (GO:0007586)2.38899268
135cellular modified amino acid catabolic process (GO:0042219)2.38619927
136response to endoplasmic reticulum stress (GO:0034976)2.38261095
137protein N-linked glycosylation (GO:0006487)2.37090355
138regulation of female receptivity (GO:0045924)2.37015395
139GDP-mannose metabolic process (GO:0019673)2.36819097
140coenzyme catabolic process (GO:0009109)2.36180509
141cell redox homeostasis (GO:0045454)2.35425723
142synaptic vesicle maturation (GO:0016188)2.34923941
143neuron cell-cell adhesion (GO:0007158)2.34516264
144detection of calcium ion (GO:0005513)2.32609984
145innervation (GO:0060384)2.32559955
146positive regulation of amino acid transport (GO:0051957)2.31978784
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.31101415
148oxaloacetate metabolic process (GO:0006107)2.30725541
149branched-chain amino acid catabolic process (GO:0009083)2.29505100
150cellular ketone body metabolic process (GO:0046950)2.28843863
151peptidyl-proline hydroxylation (GO:0019511)2.28245688
152peptidyl-glutamic acid carboxylation (GO:0017187)2.27533387
153protein carboxylation (GO:0018214)2.27533387
1544-hydroxyproline metabolic process (GO:0019471)2.23757918
155positive regulation of insulin secretion (GO:0032024)2.22273364
156regulation of neuronal synaptic plasticity (GO:0048168)2.22051706
157GTP biosynthetic process (GO:0006183)2.21705757
158short-term memory (GO:0007614)2.21696496
159insulin secretion (GO:0030073)2.20560972
160cysteine metabolic process (GO:0006534)2.20120702
161regulation of synaptic vesicle exocytosis (GO:2000300)2.19654214
162gamma-aminobutyric acid transport (GO:0015812)2.19539145
163sulfur amino acid catabolic process (GO:0000098)2.18994322
164glutamate secretion (GO:0014047)2.18960472
165galactose catabolic process (GO:0019388)2.18571727
166toxin metabolic process (GO:0009404)2.17014424
167short-chain fatty acid metabolic process (GO:0046459)2.15695144
168branched-chain amino acid metabolic process (GO:0009081)2.15629803
169response to unfolded protein (GO:0006986)2.11667385
170regulation of type B pancreatic cell apoptotic process (GO:2000674)2.11195664
171transferrin transport (GO:0033572)2.10612163
172transcytosis (GO:0045056)2.10407120
173fucose metabolic process (GO:0006004)2.10124269
174ferric iron transport (GO:0015682)2.09154535
175trivalent inorganic cation transport (GO:0072512)2.09154535
176valine metabolic process (GO:0006573)2.08500469
177nucleotide-sugar biosynthetic process (GO:0009226)2.07389890
178locomotory exploration behavior (GO:0035641)2.07344675
179regulation of oxidative phosphorylation (GO:0002082)2.07341453
180reverse cholesterol transport (GO:0043691)2.07109227
181inner ear receptor cell development (GO:0060119)2.06987709
182response to topologically incorrect protein (GO:0035966)2.06859212
183negative regulation of catecholamine secretion (GO:0033604)2.06634866
184ER to Golgi vesicle-mediated transport (GO:0006888)2.06089373
185neurotransmitter transport (GO:0006836)2.06089053
186regulation of glutamate secretion (GO:0014048)2.05613631
187regulation of synaptic vesicle transport (GO:1902803)2.05511425
188high-density lipoprotein particle remodeling (GO:0034375)2.04952132
189bile acid biosynthetic process (GO:0006699)2.04093960
190glutamate receptor signaling pathway (GO:0007215)2.03984770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.84637447
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77638073
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.62829472
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62018221
5EZH2_22144423_ChIP-Seq_EOC_Human3.46323000
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36532730
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17576763
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.00843646
9GBX2_23144817_ChIP-Seq_PC3_Human2.96054736
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.89159593
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.87886428
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.76826775
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76408706
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.60877014
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57046145
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55078370
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53520693
18ZNF263_19887448_ChIP-Seq_K562_Human2.49871408
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.45014982
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.37314885
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33093679
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31391960
23XRN2_22483619_ChIP-Seq_HELA_Human2.30637197
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28335432
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.25520530
26* GABP_19822575_ChIP-Seq_HepG2_Human2.21758066
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20353813
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.20244287
29DCP1A_22483619_ChIP-Seq_HELA_Human2.16320157
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15782632
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15225064
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12526043
33JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11946184
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09618128
35* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.06401687
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05300170
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04621738
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.03996578
39MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03243507
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97880632
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97665150
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.96833383
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.96190883
44ZNF274_21170338_ChIP-Seq_K562_Hela1.94554069
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91170814
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.90572472
47REST_21632747_ChIP-Seq_MESCs_Mouse1.88821084
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88616736
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85123918
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83309072
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83309072
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83082111
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80900452
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80638290
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79935703
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.76493163
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72392452
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71334052
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71147618
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69887718
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.69173839
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68342651
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63201101
64TAF15_26573619_Chip-Seq_HEK293_Human1.63132903
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62342561
66TTF2_22483619_ChIP-Seq_HELA_Human1.62005740
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61491891
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.59166300
69* LXR_22158963_ChIP-Seq_LIVER_Mouse1.59156122
70DROSHA_22980978_ChIP-Seq_HELA_Human1.57208577
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.55778926
72* LXR_22292898_ChIP-Seq_THP-1_Human1.54494020
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54364327
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.53642338
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.52430921
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51836694
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47951428
78IGF1R_20145208_ChIP-Seq_DFB_Human1.47119349
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46494920
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45405541
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43068372
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43068372
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42569383
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.42472442
85VDR_23849224_ChIP-Seq_CD4+_Human1.41962172
86FOXP3_21729870_ChIP-Seq_TREG_Human1.40413039
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40347265
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38316331
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.37997813
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37609029
91SMAD4_21799915_ChIP-Seq_A2780_Human1.37385741
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36071151
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35832023
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35683728
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34561039
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34034097
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33825814
98P300_19829295_ChIP-Seq_ESCs_Human1.33255943
99PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32846022
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29153591
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.27775890
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27517158
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24785145
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24307831
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24051988
106P68_20966046_ChIP-Seq_HELA_Human1.23227632
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22902886
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22349955
109KDM5A_27292631_Chip-Seq_BREAST_Human1.21689226
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20994281
111BCL6_27268052_Chip-Seq_Bcells_Human1.18583394
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18447017
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18337372
114AR_21572438_ChIP-Seq_LNCaP_Human1.17613906
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.17181325
116AR_25329375_ChIP-Seq_VCAP_Human1.17002939
117TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15964482
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15839880
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15291094
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.14711639
121BCAT_22108803_ChIP-Seq_LS180_Human1.14369129
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12810127
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12122047
124* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11368076
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10062191
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10023885
127VDR_22108803_ChIP-Seq_LS180_Human1.09617874
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.08151358
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07400523
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07384208
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07382689
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07233226
133RARB_24833708_ChIP-Seq_LIVER_Mouse1.06728927
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06289153
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05696812
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04882375
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04672590
138* SA1_27219007_Chip-Seq_ERYTHROID_Human1.04465604
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04137456
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03844193
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02691124
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02664805
143YY1_22570637_ChIP-Seq_MALME-3M_Human1.02192583
144* RACK7_27058665_Chip-Seq_MCF-7_Human1.01222890
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00450847
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00336722
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00263385
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00249579
149CBX2_27304074_Chip-Seq_ESCs_Mouse1.00121692
150RUNX2_22187159_ChIP-Seq_PCA_Human0.99715800
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99402597
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98971413
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98969315
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98759079
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98753800
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98381011
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98179118
158* PHF8_20622854_ChIP-Seq_HELA_Human0.97875300
159TFEB_21752829_ChIP-Seq_HELA_Human0.97656256
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.97582550
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97300917
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97164619
163* BCOR_27268052_Chip-Seq_Bcells_Human0.97118320
164HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96029818
165NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95576116
166THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95561055
167ER_23166858_ChIP-Seq_MCF-7_Human0.93821563
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.93576890
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93330840
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92448588
171NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91778423
172TP53_18474530_ChIP-ChIP_U2OS_Human0.90511781
173PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88796448
174PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88174691
175ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87828426
176RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87588588
177CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87485773
178P53_22387025_ChIP-Seq_ESCs_Mouse0.86278423
179ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86230137
180SOX2_21211035_ChIP-Seq_LN229_Gbm0.85954698
181MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85567195
182KDM2B_26808549_Chip-Seq_REH_Human0.85326202
183JUN_21703547_ChIP-Seq_K562_Human0.85308537
184AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84030655
185RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83752231
186TP53_22573176_ChIP-Seq_HFKS_Human0.83748828
187TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83087862
188BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81563274
189GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81369408
190SOX2_20726797_ChIP-Seq_SW620_Human0.80912314
191PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80698229
192CBP_20019798_ChIP-Seq_JUKART_Human0.80582912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.57240451
2MP0002139_abnormal_hepatobiliary_system3.31717009
3MP0003806_abnormal_nucleotide_metabolis2.89643155
4MP0005365_abnormal_bile_salt2.86334779
5MP0003186_abnormal_redox_activity2.85359657
6MP0004859_abnormal_synaptic_plasticity2.68687133
7MP0010386_abnormal_urinary_bladder2.58571441
8MP0005220_abnormal_exocrine_pancreas2.49738226
9MP0009379_abnormal_foot_pigmentation2.48012003
10MP0004272_abnormal_basement_membrane2.43644959
11MP0001666_abnormal_nutrient_absorption2.41636761
12MP0003195_calcinosis2.36576468
13MP0005083_abnormal_biliary_tract2.34256050
14MP0004043_abnormal_pH_regulation2.33716087
15MP0005171_absent_coat_pigmentation2.27486295
16MP0009780_abnormal_chondrocyte_physiolo2.27424999
17MP0005257_abnormal_intraocular_pressure2.27331338
18MP0002909_abnormal_adrenal_gland2.24117976
19MP0003868_abnormal_feces_composition2.23662618
20MP0003635_abnormal_synaptic_transmissio2.20660405
21MP0004147_increased_porphyrin_level2.18916168
22MP0005085_abnormal_gallbladder_physiolo2.13551346
23MP0003880_abnormal_central_pattern2.10055135
24MP0006036_abnormal_mitochondrial_physio2.06401429
25MP0005379_endocrine/exocrine_gland_phen2.04049120
26MP0000751_myopathy2.02029599
27MP0002254_reproductive_system_inflammat1.98410155
28MP0001944_abnormal_pancreas_morphology1.91984441
29MP0002938_white_spotting1.90130034
30MP0009745_abnormal_behavioral_response1.89144025
31MP0008438_abnormal_cutaneous_collagen1.88743283
32MP0002822_catalepsy1.88239451
33MP0005646_abnormal_pituitary_gland1.87355357
34MP0006276_abnormal_autonomic_nervous1.86672369
35MP0002876_abnormal_thyroid_physiology1.86297513
36MP0002693_abnormal_pancreas_physiology1.82002804
37MP0000013_abnormal_adipose_tissue1.79774965
38MP0002837_dystrophic_cardiac_calcinosis1.78389864
39MP0001968_abnormal_touch/_nociception1.78196523
40MP0005360_urolithiasis1.75847325
41MP0004270_analgesia1.74175576
42MP0002736_abnormal_nociception_after1.72414141
43MP0000566_synostosis1.72107925
44MP0002063_abnormal_learning/memory/cond1.70406487
45MP0002064_seizures1.69478320
46MP0000372_irregular_coat_pigmentation1.67767110
47MP0009840_abnormal_foam_cell1.64566179
48MP0008789_abnormal_olfactory_epithelium1.61289054
49MP0002572_abnormal_emotion/affect_behav1.59991401
50MP0002734_abnormal_mechanical_nocicepti1.58903960
51MP0003183_abnormal_peptide_metabolism1.58841225
52MP0003959_abnormal_lean_body1.58309339
53MP0002653_abnormal_ependyma_morphology1.55718607
54MP0005332_abnormal_amino_acid1.52631015
55MP0008058_abnormal_DNA_repair1.50113662
56MP0008875_abnormal_xenobiotic_pharmacok1.49004017
57MP0000358_abnormal_cell_content/1.46573223
58MP0003786_premature_aging1.46205624
59MP0001765_abnormal_ion_homeostasis1.44323339
60MP0001188_hyperpigmentation1.42709884
61MP0005084_abnormal_gallbladder_morpholo1.41417952
62MP0008932_abnormal_embryonic_tissue1.39337159
63MP0001664_abnormal_digestion1.38722564
64MP0004133_heterotaxia1.38018858
65MP0002877_abnormal_melanocyte_morpholog1.37955826
66MP0010329_abnormal_lipoprotein_level1.37875342
67MP0003136_yellow_coat_color1.37363440
68MP0005499_abnormal_olfactory_system1.34295737
69MP0005394_taste/olfaction_phenotype1.34295737
70MP0005636_abnormal_mineral_homeostasis1.34137302
71MP0005508_abnormal_skeleton_morphology1.33470573
72MP0003279_aneurysm1.32423160
73MP0005645_abnormal_hypothalamus_physiol1.31542900
74MP0001501_abnormal_sleep_pattern1.30966564
75MP0006035_abnormal_mitochondrial_morpho1.30461099
76MP0003111_abnormal_nucleus_morphology1.29904016
77MP0001440_abnormal_grooming_behavior1.29877510
78MP0003329_amyloid_beta_deposits1.28555250
79MP0003122_maternal_imprinting1.27583473
80MP0002078_abnormal_glucose_homeostasis1.27528772
81MP0006054_spinal_hemorrhage1.26317502
82MP0001243_abnormal_dermal_layer1.25979988
83MP0001970_abnormal_pain_threshold1.25854804
84MP0005535_abnormal_body_temperature1.24617830
85MP0002272_abnormal_nervous_system1.22532058
86MP0003656_abnormal_erythrocyte_physiolo1.22352559
87MP0003011_delayed_dark_adaptation1.20576677
88MP0009046_muscle_twitch1.20449072
89MP0000003_abnormal_adipose_tissue1.19783565
90MP0002733_abnormal_thermal_nociception1.18810679
91MP0002557_abnormal_social/conspecific_i1.18486735
92MP0004957_abnormal_blastocyst_morpholog1.16873313
93MP0005058_abnormal_lysosome_morphology1.16053348
94MP0002735_abnormal_chemical_nociception1.14015958
95MP0002295_abnormal_pulmonary_circulatio1.12751423
96MP0002163_abnormal_gland_morphology1.12415409
97MP0001756_abnormal_urination1.10597951
98MP0000538_abnormal_urinary_bladder1.09814919
99MP0000750_abnormal_muscle_regeneration1.08840733
100MP0001764_abnormal_homeostasis1.07538160
101MP0001958_emphysema1.07382294
102MP0002118_abnormal_lipid_homeostasis1.04984030
103MP0003718_maternal_effect1.03819323
104MP0001905_abnormal_dopamine_level1.02751965
105MP0003879_abnormal_hair_cell1.01176755
106MP0003283_abnormal_digestive_organ1.00592618
107MP0002060_abnormal_skin_morphology1.00010016
108MP0001529_abnormal_vocalization0.99889107
109MP0005410_abnormal_fertilization0.99382850
110MP0002184_abnormal_innervation0.98741398
111MP0000639_abnormal_adrenal_gland0.98440679
112MP0002067_abnormal_sensory_capabilities0.98231901
113MP0005330_cardiomyopathy0.98080459
114MP0000613_abnormal_salivary_gland0.97056576
115MP0002069_abnormal_eating/drinking_beha0.96496354
116MP0003953_abnormal_hormone_level0.95880210
117MP0003693_abnormal_embryo_hatching0.95175600
118MP0004924_abnormal_behavior0.95050460
119MP0005386_behavior/neurological_phenoty0.95050460
120MP0005448_abnormal_energy_balance0.94702546
121MP0005408_hypopigmentation0.93499131
122MP0000230_abnormal_systemic_arterial0.92668396
123MP0005423_abnormal_somatic_nervous0.92083968
124MP0004142_abnormal_muscle_tone0.90929069
125MP0005501_abnormal_skin_physiology0.90030517
126MP0002282_abnormal_trachea_morphology0.89963618
127MP0001502_abnormal_circadian_rhythm0.89702712
128MP0001299_abnormal_eye_distance/0.89490516
129MP0005503_abnormal_tendon_morphology0.89338203
130MP0001486_abnormal_startle_reflex0.88600046
131MP0000049_abnormal_middle_ear0.88032815
132MP0009384_cardiac_valve_regurgitation0.86972016
133MP0000749_muscle_degeneration0.86484417
134MP0005595_abnormal_vascular_smooth0.86202104
135MP0005551_abnormal_eye_electrophysiolog0.85823439
136MP0000604_amyloidosis0.85187221
137MP0009643_abnormal_urine_homeostasis0.83773828
138MP0003252_abnormal_bile_duct0.82915170
139MP0003315_abnormal_perineum_morphology0.82908462
140MP0000762_abnormal_tongue_morphology0.82489730
141MP0002638_abnormal_pupillary_reflex0.80720209
142MP0005165_increased_susceptibility_to0.79987636
143MP0005451_abnormal_body_composition0.79402143
144MP0008007_abnormal_cellular_replicative0.78721763
145MP0004858_abnormal_nervous_system0.78414140
146MP0002896_abnormal_bone_mineralization0.78381571
147MP0003172_abnormal_lysosome_physiology0.78090809
148MP0001542_abnormal_bone_strength0.77821886
149MP0005197_abnormal_uvea_morphology0.77762107
150MP0005584_abnormal_enzyme/coenzyme_acti0.77671987
151MP0005670_abnormal_white_adipose0.77622367
152MP0000631_abnormal_neuroendocrine_gland0.77593860
153MP0000955_abnormal_spinal_cord0.76048110
154MP0002066_abnormal_motor_capabilities/c0.75447484
155MP0003942_abnormal_urinary_system0.74309800
156MP0003385_abnormal_body_wall0.74147950
157MP0000681_abnormal_thyroid_gland0.73577181
158MP0002090_abnormal_vision0.73173774
159MP0006072_abnormal_retinal_apoptosis0.69620841
160MP0003191_abnormal_cellular_cholesterol0.68116267
161MP0005623_abnormal_meninges_morphology0.67734151
162MP0005193_abnormal_anterior_eye0.67468766
163MP0010771_integument_phenotype0.64906949
164MP0001661_extended_life_span0.64422040
165MP0002177_abnormal_outer_ear0.64176460
166MP0004019_abnormal_vitamin_homeostasis0.63317436
167MP0001881_abnormal_mammary_gland0.63304302
168MP0003137_abnormal_impulse_conducting0.63237664
169MP0002234_abnormal_pharynx_morphology0.63188045

Predicted human phenotypes

RankGene SetZ-score
1Increased CSF lactate (HP:0002490)3.74519992
2Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69307654
3Ketoacidosis (HP:0001993)3.69201599
4Hyperinsulinemic hypoglycemia (HP:0000825)3.67310347
5Type I transferrin isoform profile (HP:0003642)3.57683325
6Vertebral compression fractures (HP:0002953)3.54660560
7Hypoglycemic seizures (HP:0002173)3.49322709
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37568264
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37568264
10Abnormal number of erythroid precursors (HP:0012131)3.27887205
11Focal motor seizures (HP:0011153)3.22036796
12Abnormality of the intrinsic pathway (HP:0010989)3.21822794
13Hypoglycemic coma (HP:0001325)3.19088547
14Ketosis (HP:0001946)3.15384181
15Abnormal gallbladder physiology (HP:0012438)3.14591227
16Cholecystitis (HP:0001082)3.14591227
17Hypokinesia (HP:0002375)3.01030378
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00107049
19Abnormal protein N-linked glycosylation (HP:0012347)3.00107049
20Abnormal protein glycosylation (HP:0012346)3.00107049
21Abnormal glycosylation (HP:0012345)3.00107049
22Symptomatic seizures (HP:0011145)2.92792412
23Abnormality of glycolysis (HP:0004366)2.90968722
24Renal Fanconi syndrome (HP:0001994)2.87422580
25Increased hepatocellular lipid droplets (HP:0006565)2.82062537
26Prolonged neonatal jaundice (HP:0006579)2.81263771
27Visual hallucinations (HP:0002367)2.80652838
28Abnormality of liposaccharide metabolism (HP:0010968)2.80335262
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.80335262
30Abnormality of glycolipid metabolism (HP:0010969)2.80335262
31Lactic acidosis (HP:0003128)2.79344836
32Exercise intolerance (HP:0003546)2.78235280
33Premature rupture of membranes (HP:0001788)2.76566472
34Lipid accumulation in hepatocytes (HP:0006561)2.76177808
35Respiratory failure (HP:0002878)2.72654351
36Increased serum pyruvate (HP:0003542)2.68158443
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67717125
38Abnormality of the common coagulation pathway (HP:0010990)2.66786401
39Abnormality of cells of the erythroid lineage (HP:0012130)2.61664622
40Agitation (HP:0000713)2.60139247
41Abnormal pupillary function (HP:0007686)2.60067312
42Hypothermia (HP:0002045)2.59356187
43Retinal atrophy (HP:0001105)2.58052766
44Dysostosis multiplex (HP:0000943)2.57379130
45Increased intramyocellular lipid droplets (HP:0012240)2.47850694
46Mucopolysacchariduria (HP:0008155)2.47170252
47Urinary glycosaminoglycan excretion (HP:0003541)2.47170252
48Prolonged partial thromboplastin time (HP:0003645)2.46470197
49Increased serum lactate (HP:0002151)2.45067754
50Opisthotonus (HP:0002179)2.43314480
51Hyperglycinemia (HP:0002154)2.40109754
52Increased muscle lipid content (HP:0009058)2.38447028
53Fat malabsorption (HP:0002630)2.37110391
54Focal seizures (HP:0007359)2.36297708
55Type II lissencephaly (HP:0007260)2.35164885
56Conjugated hyperbilirubinemia (HP:0002908)2.33925598
57Epileptiform EEG discharges (HP:0011182)2.32994789
58Generalized tonic-clonic seizures (HP:0002069)2.32443819
59Intrahepatic cholestasis (HP:0001406)2.30837793
60Hepatic necrosis (HP:0002605)2.30113831
61EEG with generalized epileptiform discharges (HP:0011198)2.27306492
62Hepatocellular necrosis (HP:0001404)2.26949409
63Atonic seizures (HP:0010819)2.25198221
64Emotional lability (HP:0000712)2.24722476
65Cholelithiasis (HP:0001081)2.24538428
66Acute encephalopathy (HP:0006846)2.24081154
67Absence seizures (HP:0002121)2.23803941
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22823687
69Hyperglycemia (HP:0003074)2.22615769
70Degeneration of anterior horn cells (HP:0002398)2.22399265
71Abnormality of the anterior horn cell (HP:0006802)2.22399265
72Abnormal gallbladder morphology (HP:0012437)2.21470445
73Dicarboxylic aciduria (HP:0003215)2.20361482
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20361482
75Broad distal phalanx of finger (HP:0009836)2.19964235
76Xanthomatosis (HP:0000991)2.19718002
77Late onset (HP:0003584)2.18630879
78Hypsarrhythmia (HP:0002521)2.16951697
79Microvesicular hepatic steatosis (HP:0001414)2.16915957
80Acute necrotizing encephalopathy (HP:0006965)2.14441884
81Abnormality of polysaccharide metabolism (HP:0011012)2.13701019
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13701019
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13701019
84Methylmalonic aciduria (HP:0012120)2.12913286
85Abnormal mitochondria in muscle tissue (HP:0008316)2.12895148
86Protrusio acetabuli (HP:0003179)2.12330073
87Mitochondrial inheritance (HP:0001427)2.11598067
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10593481
89Insulin-resistant diabetes mellitus (HP:0000831)2.09066184
90Epileptic encephalopathy (HP:0200134)2.08249127
91Status epilepticus (HP:0002133)2.07411593
92Reduced antithrombin III activity (HP:0001976)2.06432660
93Abnormality of calcium-phosphate metabolism (HP:0100530)2.03906555
94Joint stiffness (HP:0001387)2.03311267
95Beaking of vertebral bodies (HP:0004568)2.02417856
96Hypophosphatemic rickets (HP:0004912)2.02260835
97Vacuolated lymphocytes (HP:0001922)2.01923066
98Lethargy (HP:0001254)2.01572614
99Retinal dysplasia (HP:0007973)2.00244893
100Cerebral palsy (HP:0100021)1.99202538
101Dialeptic seizures (HP:0011146)1.98471179
102Congenital sensorineural hearing impairment (HP:0008527)1.98397960
103Poor suck (HP:0002033)1.95077480
104Delayed CNS myelination (HP:0002188)1.94943339
105CNS demyelination (HP:0007305)1.94703650
106Polyphagia (HP:0002591)1.94286811
107Abnormality of serine family amino acid metabolism (HP:0010894)1.93604593
108Abnormality of glycine metabolism (HP:0010895)1.93604593
1093-Methylglutaconic aciduria (HP:0003535)1.92350139
110Abnormality of the Achilles tendon (HP:0005109)1.92265989
111Microretrognathia (HP:0000308)1.91885056
112Anxiety (HP:0000739)1.91803612
113Abnormality of dentin (HP:0010299)1.90516237
114Progressive macrocephaly (HP:0004481)1.90460356
115Hyperventilation (HP:0002883)1.89119746
116Severe muscular hypotonia (HP:0006829)1.88089686
117Cerebral edema (HP:0002181)1.87247494
118Cervical subluxation (HP:0003308)1.87216478
119Upper limb muscle weakness (HP:0003484)1.87182871
120Rough bone trabeculation (HP:0100670)1.87124701
121Hypoalphalipoproteinemia (HP:0003233)1.85675228
122Achilles tendon contracture (HP:0001771)1.84530221
123Hyperphosphaturia (HP:0003109)1.84078971
124Deep venous thrombosis (HP:0002625)1.84012908
125Progressive neurologic deterioration (HP:0002344)1.83379689
126Optic disc pallor (HP:0000543)1.83039262
127Rhinitis (HP:0012384)1.82994491
128Cerebral inclusion bodies (HP:0100314)1.82164992
129Generalized aminoaciduria (HP:0002909)1.81807939
130Biconcave vertebral bodies (HP:0004586)1.81700043
131Trismus (HP:0000211)1.80705610
132Steatorrhea (HP:0002570)1.80585348
133Type I diabetes mellitus (HP:0100651)1.80342663
134Spastic paraparesis (HP:0002313)1.79833648
135J-shaped sella turcica (HP:0002680)1.79689903
136Short nail (HP:0001799)1.78544997
137Restlessness (HP:0000711)1.78230065
138Complement deficiency (HP:0004431)1.78137629
139Nuclear cataract (HP:0100018)1.78132359
140Tubulointerstitial nephritis (HP:0001970)1.77697698
141Hypobetalipoproteinemia (HP:0003563)1.77588973
142Redundant skin (HP:0001582)1.77397338
143Abnormality of dental color (HP:0011073)1.77324420
144Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76917610
145Hypolipoproteinemia (HP:0010981)1.76555834
146Neurofibrillary tangles (HP:0002185)1.75566063
147Gout (HP:0001997)1.75492182
148Abnormality of the gallbladder (HP:0005264)1.75400742
149Absent epiphyses (HP:0010577)1.75290880
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75290880
151Protuberant abdomen (HP:0001538)1.74719865
152Pancreatitis (HP:0001733)1.73611494
153Sensorimotor neuropathy (HP:0007141)1.73565242
154Ragged-red muscle fibers (HP:0003200)1.73109304
155Hyperlipoproteinemia (HP:0010980)1.72536975
156Reticulocytosis (HP:0001923)1.72369187
157Diminished movement (HP:0002374)1.72162068
158Progressive microcephaly (HP:0000253)1.71198523
159Hand muscle atrophy (HP:0009130)1.71024036
160Spinal rigidity (HP:0003306)1.70874529
161Generalized amyotrophy (HP:0003700)1.70599485
162Supranuclear gaze palsy (HP:0000605)1.69494609
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69328604
164Fasciculations (HP:0002380)1.69064044
165Myokymia (HP:0002411)1.68986267
166Cerebral hypomyelination (HP:0006808)1.68560784
167Congenital glaucoma (HP:0001087)1.68238142
168Blindness (HP:0000618)1.67868105
169Abnormality of complement system (HP:0005339)1.67849518
170Testicular atrophy (HP:0000029)1.67564199
171Hyperglycinuria (HP:0003108)1.67399681
172Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65545470
173Delusions (HP:0000746)1.65407282
174Abnormal eating behavior (HP:0100738)1.64976841
175Breech presentation (HP:0001623)1.63319372
176Exertional dyspnea (HP:0002875)1.62580246
177Distal upper limb amyotrophy (HP:0007149)1.60200037
178Upper limb amyotrophy (HP:0009129)1.60200037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.42285561
2TESK13.91535392
3NTRK33.85793972
4TESK23.43115326
5BCKDK3.26736207
6LIMK12.92858216
7NME12.91318163
8INSRR2.82060851
9CASK2.55717049
10EPHA42.44071300
11BUB12.38941577
12MAP2K72.30383979
13FRK2.19887104
14AKT32.18048111
15EPHA22.13944929
16TAOK31.96799513
17MAPK151.95951138
18ARAF1.91846836
19FER1.87448513
20SCYL21.86331972
21KDR1.85519225
22FES1.81268105
23MINK11.76793617
24MAP4K21.73765166
25MAP3K41.72905020
26MAP3K21.72281378
27CSNK1G31.70693714
28DAPK21.62602808
29ABL21.59362976
30PAK41.57732597
31MARK11.55728470
32NTRK11.55291929
33PRKD31.54198018
34TLK11.53677433
35VRK11.53137092
36MAPKAPK31.52367269
37MAP3K111.51510858
38MAP2K41.47848296
39CAMKK21.40940413
40PNCK1.38580276
41ERN11.38001965
42CSNK1A1L1.27773786
43TAOK21.25049608
44WNK41.21283825
45MAP3K91.17471189
46CSNK1G21.14851125
47CSNK1G11.13535520
48NEK11.12404742
49RIPK41.11513025
50GRK51.11477488
51SMG11.11230460
52PLK21.09378266
53STK161.09048405
54BRAF1.08199096
55MAP3K121.06935939
56PRKCG1.06686370
57DYRK21.02745994
58CDK191.02180131
59MAP3K11.01993278
60MAPK131.01955692
61PIK3CG1.00762946
62CAMK2A1.00353269
63CAMKK11.00008928
64SRPK10.99969869
65TNIK0.99868258
66CAMK2D0.99659604
67PRKCE0.98503785
68EPHB20.98194800
69AURKA0.96591788
70BRSK10.96172781
71CAMK2B0.95309146
72IRAK20.91259229
73EIF2AK30.90266830
74PTK2B0.89964199
75KSR20.88139898
76CDK80.87621113
77TAF10.85516031
78LMTK20.85426574
79CDK50.85024651
80EPHA30.82788267
81CAMK2G0.81303962
82DAPK30.80964146
83MAP2K10.80918048
84IRAK30.80411475
85ADRBK10.79110847
86BMPR20.78704892
87NUAK10.76981759
88WNK30.75734977
89RET0.75341891
90ADRBK20.75191426
91MST1R0.73612648
92PDK30.73374152
93PDK40.73374152
94NTRK20.70728784
95CAMK10.70251010
96EIF2AK10.69719796
97PDK20.69548989
98CCNB10.69514988
99PLK10.66568665
100ILK0.66382047
101MYLK0.65484088
102NEK90.65211229
103PLK30.64931673
104MAPKAPK50.63889269
105RAF10.63074406
106PRKD20.63039902
107MST40.61702435
108CDK11A0.61030124
109DDR20.60745783
110PAK30.59940509
111PAK10.59512867
112UHMK10.58625016
113PRKCI0.58540269
114CAMK1G0.58164243
115KSR10.56952636
116CDK150.56875720
117DAPK10.56805163
118CDK180.56672314
119ICK0.56180530
120NEK60.54453828
121TRIB30.54152896
122PIM20.53630314
123RPS6KA50.53510531
124SIK10.53264058
125NME20.53242814
126AURKB0.52602733
127CDK140.52178725
128DYRK1A0.51966582
129RPS6KA20.50647324
130BMX0.50411979
131CDK70.49281769
132CDC42BPA0.47969508
133MET0.47643001
134PHKG10.47214659
135PHKG20.47214659
136PDPK10.46915395
137MAP2K20.45848283
138CSNK2A10.45737880
139GRK70.45604586
140PAK60.45327162
141FLT30.44521470
142AKT20.44017982
143HIPK20.43875187
144DMPK0.42878994
145MAP2K60.42406260
146PRKCA0.41755698
147GRK10.41507422
148PTK20.40302550
149CHEK20.39502779
150BMPR1B0.38879030
151CSNK2A20.38561978
152PRKCZ0.38549606
153CDC70.38503000
154ATR0.38312328
155LATS20.37346116
156CSNK1A10.35592510
157LRRK20.34966676
158PBK0.34946166
159ERBB40.34748832
160TAOK10.33454408
161RPS6KA40.32022822
162PRKD10.31537833
163TRIM280.30900349
164TBK10.30389688
165PINK10.29290649

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.20978630
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.38838900
3Proteasome_Homo sapiens_hsa030503.14546370
4Sulfur metabolism_Homo sapiens_hsa009202.71554982
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41094032
6Ribosome_Homo sapiens_hsa030102.30033440
7Vibrio cholerae infection_Homo sapiens_hsa051102.23305424
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11344279
9Synaptic vesicle cycle_Homo sapiens_hsa047212.08718017
10DNA replication_Homo sapiens_hsa030302.08406471
11Base excision repair_Homo sapiens_hsa034102.06633207
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04263973
13RNA polymerase_Homo sapiens_hsa030202.01413577
14Oxidative phosphorylation_Homo sapiens_hsa001901.92741912
15Nicotine addiction_Homo sapiens_hsa050331.92490730
16Biosynthesis of amino acids_Homo sapiens_hsa012301.92171338
17Collecting duct acid secretion_Homo sapiens_hsa049661.85845237
18Insulin secretion_Homo sapiens_hsa049111.77586118
19Pyrimidine metabolism_Homo sapiens_hsa002401.77404540
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.76026261
21Glutathione metabolism_Homo sapiens_hsa004801.75684582
22Carbon metabolism_Homo sapiens_hsa012001.66114286
23Pancreatic secretion_Homo sapiens_hsa049721.66107480
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60342508
25Amphetamine addiction_Homo sapiens_hsa050311.58961401
26Fructose and mannose metabolism_Homo sapiens_hsa000511.58646605
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56549222
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45689763
29GABAergic synapse_Homo sapiens_hsa047271.44756975
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42644002
31Pentose phosphate pathway_Homo sapiens_hsa000301.40884577
32Mismatch repair_Homo sapiens_hsa034301.39395934
33N-Glycan biosynthesis_Homo sapiens_hsa005101.39167516
34Fat digestion and absorption_Homo sapiens_hsa049751.37338271
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32901151
36Nitrogen metabolism_Homo sapiens_hsa009101.31526222
37Butanoate metabolism_Homo sapiens_hsa006501.29891877
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28316918
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27434594
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24948281
41Alzheimers disease_Homo sapiens_hsa050101.24709032
42Cocaine addiction_Homo sapiens_hsa050301.23462268
43Parkinsons disease_Homo sapiens_hsa050121.22694710
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22206516
45Tryptophan metabolism_Homo sapiens_hsa003801.22059274
46Homologous recombination_Homo sapiens_hsa034401.19267810
47Propanoate metabolism_Homo sapiens_hsa006401.17872547
48Circadian entrainment_Homo sapiens_hsa047131.13630499
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13622994
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12566093
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.11287570
52Arginine biosynthesis_Homo sapiens_hsa002201.11159380
53Nucleotide excision repair_Homo sapiens_hsa034201.10492161
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10148585
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09854684
56Dopaminergic synapse_Homo sapiens_hsa047281.08433265
57Long-term potentiation_Homo sapiens_hsa047201.07600879
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06862475
59Purine metabolism_Homo sapiens_hsa002301.06483895
60Morphine addiction_Homo sapiens_hsa050321.06217019
61Protein digestion and absorption_Homo sapiens_hsa049741.04284786
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.97303803
63Taste transduction_Homo sapiens_hsa047420.96252186
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96012612
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94189582
66Folate biosynthesis_Homo sapiens_hsa007900.93732721
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93485489
68Fatty acid degradation_Homo sapiens_hsa000710.93120201
69Other glycan degradation_Homo sapiens_hsa005110.91099307
70Glutamatergic synapse_Homo sapiens_hsa047240.90892540
71Spliceosome_Homo sapiens_hsa030400.89742085
72Vitamin B6 metabolism_Homo sapiens_hsa007500.88487966
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86971032
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86465673
75Thyroid hormone synthesis_Homo sapiens_hsa049180.86044082
76Galactose metabolism_Homo sapiens_hsa000520.83629181
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80937461
78Pyruvate metabolism_Homo sapiens_hsa006200.80374698
79Starch and sucrose metabolism_Homo sapiens_hsa005000.80282158
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80248626
81Serotonergic synapse_Homo sapiens_hsa047260.80013142
82One carbon pool by folate_Homo sapiens_hsa006700.79618028
83Lysosome_Homo sapiens_hsa041420.78692642
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78011654
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77475996
86Peroxisome_Homo sapiens_hsa041460.76009350
87Cholinergic synapse_Homo sapiens_hsa047250.75233347
88Renin secretion_Homo sapiens_hsa049240.74610594
89Olfactory transduction_Homo sapiens_hsa047400.74431844
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73087336
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72337375
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72061922
93Gastric acid secretion_Homo sapiens_hsa049710.71651591
94Salivary secretion_Homo sapiens_hsa049700.71145762
95Huntingtons disease_Homo sapiens_hsa050160.70170543
96Histidine metabolism_Homo sapiens_hsa003400.68856457
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67293483
98Calcium signaling pathway_Homo sapiens_hsa040200.66746009
99Prion diseases_Homo sapiens_hsa050200.66303432
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65862928
101Complement and coagulation cascades_Homo sapiens_hsa046100.65802373
102Sulfur relay system_Homo sapiens_hsa041220.65426218
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64449812
104Glycerolipid metabolism_Homo sapiens_hsa005610.64003842
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62923833
106Phenylalanine metabolism_Homo sapiens_hsa003600.62481882
107Fanconi anemia pathway_Homo sapiens_hsa034600.61396880
108Bile secretion_Homo sapiens_hsa049760.61048254
109Fatty acid elongation_Homo sapiens_hsa000620.60994578
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60248947
111Fatty acid metabolism_Homo sapiens_hsa012120.60152103
112Long-term depression_Homo sapiens_hsa047300.59934121
113Vitamin digestion and absorption_Homo sapiens_hsa049770.59648452
114Selenocompound metabolism_Homo sapiens_hsa004500.59493316
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59235702
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58071202
117RNA transport_Homo sapiens_hsa030130.57811698
118Cardiac muscle contraction_Homo sapiens_hsa042600.57798426
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.57398480
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54749569
121Sphingolipid metabolism_Homo sapiens_hsa006000.54495902
122Regulation of autophagy_Homo sapiens_hsa041400.53508753
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53354631
124Arginine and proline metabolism_Homo sapiens_hsa003300.53295739
125beta-Alanine metabolism_Homo sapiens_hsa004100.53085961
126Renin-angiotensin system_Homo sapiens_hsa046140.51185417
127Type II diabetes mellitus_Homo sapiens_hsa049300.49876461
128Metabolic pathways_Homo sapiens_hsa011000.49296710
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.49228546
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48032868
131Steroid biosynthesis_Homo sapiens_hsa001000.47148627
132Tyrosine metabolism_Homo sapiens_hsa003500.46092795
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40593400
134Chemical carcinogenesis_Homo sapiens_hsa052040.40378465
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39989046
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38919464
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34843142
138Basal transcription factors_Homo sapiens_hsa030220.26281962
139p53 signaling pathway_Homo sapiens_hsa041150.20596824
140Bladder cancer_Homo sapiens_hsa052190.20471909
141ECM-receptor interaction_Homo sapiens_hsa045120.18891123
142Arachidonic acid metabolism_Homo sapiens_hsa005900.18818048
143Non-homologous end-joining_Homo sapiens_hsa034500.18599293
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.17974979

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »