CHKA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)7.37130856
2intestinal epithelial cell development (GO:0060576)5.85808374
3UDP-N-acetylglucosamine metabolic process (GO:0006047)5.21791679
4axon ensheathment in central nervous system (GO:0032291)4.77693981
5central nervous system myelination (GO:0022010)4.77693981
6purine nucleobase biosynthetic process (GO:0009113)4.73900138
7very-low-density lipoprotein particle assembly (GO:0034379)4.58869886
8plasma lipoprotein particle assembly (GO:0034377)4.42319882
9intestinal cholesterol absorption (GO:0030299)4.39079681
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29297631
11L-phenylalanine metabolic process (GO:0006558)4.29297631
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23766855
13L-phenylalanine catabolic process (GO:0006559)4.23766855
14dicarboxylic acid biosynthetic process (GO:0043650)4.18537495
15pyrimidine-containing compound transmembrane transport (GO:0072531)4.15359811
16regulation of cholesterol biosynthetic process (GO:0045540)4.09551417
17protein-lipid complex assembly (GO:0065005)3.93270963
18glutamine family amino acid biosynthetic process (GO:0009084)3.90477639
19folic acid metabolic process (GO:0046655)3.85857368
20regulation of bile acid biosynthetic process (GO:0070857)3.85388043
21nucleotide-sugar biosynthetic process (GO:0009226)3.81979799
22GMP metabolic process (GO:0046037)3.81502908
23serine family amino acid catabolic process (GO:0009071)3.78145929
24regulation of glucokinase activity (GO:0033131)3.73988481
25regulation of hexokinase activity (GO:1903299)3.73988481
26vitamin transport (GO:0051180)3.70233651
27modified amino acid transport (GO:0072337)3.68862477
28pyrimidine dimer repair (GO:0006290)3.66452195
29regulation of cholesterol esterification (GO:0010872)3.65817862
30glutamate metabolic process (GO:0006536)3.64234396
31autophagic vacuole assembly (GO:0000045)3.63912742
32regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.60457101
33low-density lipoprotein particle remodeling (GO:0034374)3.58332931
34lung-associated mesenchyme development (GO:0060484)3.58326297
35nucleobase biosynthetic process (GO:0046112)3.57142179
36glandular epithelial cell differentiation (GO:0002067)3.56028904
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.52002161
38lung epithelium development (GO:0060428)3.46495650
39S-adenosylmethionine metabolic process (GO:0046500)3.43448927
40peptidyl-glutamic acid carboxylation (GO:0017187)3.43403897
41protein carboxylation (GO:0018214)3.43403897
42folic acid transport (GO:0015884)3.42569512
43mitotic metaphase plate congression (GO:0007080)3.41403779
44cholesterol efflux (GO:0033344)3.39564196
45ribosome assembly (GO:0042255)3.35228781
46labyrinthine layer development (GO:0060711)3.33708552
47cell-cell junction maintenance (GO:0045217)3.31051977
48monoubiquitinated protein deubiquitination (GO:0035520)3.30858550
49intestinal absorption (GO:0050892)3.28914454
50eye photoreceptor cell differentiation (GO:0001754)3.28686363
51photoreceptor cell differentiation (GO:0046530)3.28686363
52negative regulation of sterol transport (GO:0032372)3.28404790
53negative regulation of cholesterol transport (GO:0032375)3.28404790
54plasma lipoprotein particle remodeling (GO:0034369)3.28240625
55protein-lipid complex remodeling (GO:0034368)3.28240625
56macromolecular complex remodeling (GO:0034367)3.28240625
57pantothenate metabolic process (GO:0015939)3.28042565
58negative regulation of transcription by competitive promoter binding (GO:0010944)3.27864593
59GDP-mannose metabolic process (GO:0019673)3.27753191
60sulfur compound transport (GO:0072348)3.27069596
61endocrine pancreas development (GO:0031018)3.26896541
62plasma lipoprotein particle organization (GO:0071827)3.22659568
63poly(A)+ mRNA export from nucleus (GO:0016973)3.19481231
64plasma lipoprotein particle clearance (GO:0034381)3.17849855
65positive regulation of Cdc42 GTPase activity (GO:0043089)3.17138319
66early endosome to late endosome transport (GO:0045022)3.12848706
67macroautophagy (GO:0016236)3.12094946
68regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.08448095
69regulation of fibrinolysis (GO:0051917)3.08002306
70biotin metabolic process (GO:0006768)3.07993097
71regulation of cholesterol metabolic process (GO:0090181)3.07090627
72embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05725392
73regulation of apoptotic cell clearance (GO:2000425)3.05470311
74cofactor transport (GO:0051181)3.03635559
75protein-lipid complex subunit organization (GO:0071825)3.03157753
76peptide hormone processing (GO:0016486)2.99584541
77columnar/cuboidal epithelial cell development (GO:0002066)2.99254137
78reverse cholesterol transport (GO:0043691)2.98407347
79regulation of protein activation cascade (GO:2000257)2.95242439
80high-density lipoprotein particle remodeling (GO:0034375)2.93710993
81L-amino acid import (GO:0043092)2.93031167
82urea cycle (GO:0000050)2.91632536
83replicative senescence (GO:0090399)2.90397899
84mitotic chromosome condensation (GO:0007076)2.89064900
85alpha-linolenic acid metabolic process (GO:0036109)2.86132502
86regulation of complement activation (GO:0030449)2.85773815
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81199167
88urate metabolic process (GO:0046415)2.80407534
89glycine metabolic process (GO:0006544)2.80275608
90histone H2A monoubiquitination (GO:0035518)2.79184586
91positive regulation of autophagy (GO:0010508)2.78772658
92proline metabolic process (GO:0006560)2.78546184
93COPII vesicle coating (GO:0048208)2.77782680
94CDP-diacylglycerol metabolic process (GO:0046341)2.75415056
95urea metabolic process (GO:0019627)2.75089078
96heterochromatin organization (GO:0070828)2.74397074
97regulation of spindle organization (GO:0090224)2.73985313
98cell junction maintenance (GO:0034331)2.73430234
99nucleotide-sugar metabolic process (GO:0009225)2.73164202
100neurotransmitter-gated ion channel clustering (GO:0072578)2.73060800
101diacylglycerol metabolic process (GO:0046339)2.72934684
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72545691
103amino acid import (GO:0043090)2.72040193
104synaptonemal complex assembly (GO:0007130)2.69854483
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.69103618
106regulation of inclusion body assembly (GO:0090083)2.68232533
107zinc ion transmembrane transport (GO:0071577)2.67503373
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.67455124
109angiotensin maturation (GO:0002003)2.67390818
110synapsis (GO:0007129)2.66505834
111zinc ion transport (GO:0006829)2.66171504
112trivalent inorganic anion homeostasis (GO:0072506)2.65089737
113phosphate ion homeostasis (GO:0055062)2.65089737
114glutamine family amino acid catabolic process (GO:0009065)2.64772941
115negative regulation of inclusion body assembly (GO:0090084)2.63874976
116positive regulation of DNA-templated transcription, initiation (GO:2000144)2.63179589
117oligosaccharide catabolic process (GO:0009313)2.62794264
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.62660344
119negative regulation of fibrinolysis (GO:0051918)2.62292175
120activation of Rac GTPase activity (GO:0032863)2.61964107
121regulation of cholesterol homeostasis (GO:2000188)2.61907468
122regulation of histone H3-K27 methylation (GO:0061085)2.61724758
123male meiosis I (GO:0007141)2.60658527
124meiosis I (GO:0007127)2.59903287
125cilium or flagellum-dependent cell motility (GO:0001539)2.59674539
126positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.58176524
127myelin maintenance (GO:0043217)2.57806403
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55784691
129chromosome organization involved in meiosis (GO:0070192)2.54813177
130DNA unwinding involved in DNA replication (GO:0006268)2.51608495
131negative regulation of hormone metabolic process (GO:0032351)2.51421024
132negative regulation of hormone biosynthetic process (GO:0032353)2.51421024
133positive regulation of cellular amine metabolic process (GO:0033240)2.51383190
134histone H2A ubiquitination (GO:0033522)2.50634252
135ribosome biogenesis (GO:0042254)2.50571686
136regulation of G0 to G1 transition (GO:0070316)2.50351678
137protein refolding (GO:0042026)2.50313445
138alditol phosphate metabolic process (GO:0052646)2.50252208
139low-density lipoprotein particle clearance (GO:0034383)2.49740685
140regulation of superoxide anion generation (GO:0032928)2.49094019
141amino sugar catabolic process (GO:0046348)2.48085464
142cellular zinc ion homeostasis (GO:0006882)2.47463106
143sulfate transport (GO:0008272)2.46448163
144rRNA modification (GO:0000154)2.46412536
145negative regulation of Ras GTPase activity (GO:0034261)2.46208848
146positive regulation of macroautophagy (GO:0016239)2.45078326
147metaphase plate congression (GO:0051310)2.44775835
148positive regulation of triglyceride lipase activity (GO:0061365)2.44569167
149positive regulation of lipoprotein lipase activity (GO:0051006)2.44569167
150water-soluble vitamin biosynthetic process (GO:0042364)2.44477851
151iron coordination entity transport (GO:1901678)2.43814782
152body morphogenesis (GO:0010171)2.43655538
153vacuole organization (GO:0007033)2.43424803
154oocyte maturation (GO:0001556)2.43319726
155cholesterol biosynthetic process (GO:0006695)2.41162052
156transcription elongation from RNA polymerase I promoter (GO:0006362)2.41126300
157notochord development (GO:0030903)2.41026200
158N-acetylneuraminate metabolic process (GO:0006054)2.38897611
159keratinocyte development (GO:0003334)2.38197878
160negative regulation of fatty acid biosynthetic process (GO:0045717)2.36370647
161regulation of extracellular matrix organization (GO:1903053)2.36089355
162branching involved in labyrinthine layer morphogenesis (GO:0060670)2.34925350
163mating behavior (GO:0007617)2.34861853
164positive regulation of mRNA 3-end processing (GO:0031442)2.34614568
165regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.34392688
166phospholipid efflux (GO:0033700)2.34073127
167synaptic transmission, glutamatergic (GO:0035249)2.33986733
168regulation of RNA export from nucleus (GO:0046831)2.33592269
169response to xenobiotic stimulus (GO:0009410)2.33307589
170cellular protein catabolic process (GO:0044257)2.32053446
171spliceosomal tri-snRNP complex assembly (GO:0000244)2.31684275
172branching involved in mammary gland duct morphogenesis (GO:0060444)2.31380718
173polyamine biosynthetic process (GO:0006596)2.31001852
174regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.30963418
175heme transport (GO:0015886)2.30647099
176mitotic cell cycle arrest (GO:0071850)2.30613170
177negative regulation of protein activation cascade (GO:2000258)2.30236649
178sulfate transmembrane transport (GO:1902358)2.29948994
179DNA synthesis involved in DNA repair (GO:0000731)2.29024701
180cellular response to ATP (GO:0071318)2.29013076
181proline biosynthetic process (GO:0006561)2.28769475
182spindle assembly involved in mitosis (GO:0090307)2.28731871
183synaptonemal complex organization (GO:0070193)2.27879726
184mitotic sister chromatid cohesion (GO:0007064)2.27674188
185cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.24284885
186nuclear pore complex assembly (GO:0051292)2.23875033
187ethanol oxidation (GO:0006069)2.23501889
188nitrogen cycle metabolic process (GO:0071941)2.22661075
189L-alpha-amino acid transmembrane transport (GO:1902475)2.22451263
190regulation of monocyte differentiation (GO:0045655)2.18151238
191SMAD protein signal transduction (GO:0060395)2.16595223
192paraxial mesoderm development (GO:0048339)2.16412381
193positive regulation of gluconeogenesis (GO:0045722)2.16321091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.34371721
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39989950
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.39701122
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35218105
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.28133008
6GATA1_22025678_ChIP-Seq_K562_Human3.13275549
7AR_21909140_ChIP-Seq_LNCAP_Human2.89605783
8E2F7_22180533_ChIP-Seq_HELA_Human2.59760908
9* CLOCK_20551151_ChIP-Seq_293T_Human2.49966235
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.30139823
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24083864
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.21969934
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11827708
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.07513706
15KAP1_22055183_ChIP-Seq_ESCs_Mouse2.02555044
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97542067
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96475504
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93909258
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93291736
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93226345
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.90062268
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89271509
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89239217
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87052564
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85066364
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84896810
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82554183
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81294367
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.79933958
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.79757113
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77283283
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.76665865
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.74182733
34* MYC_18555785_ChIP-Seq_MESCs_Mouse1.69820569
35* KDM2B_26808549_Chip-Seq_K562_Human1.68838684
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68585794
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68392450
38LXR_22292898_ChIP-Seq_THP-1_Human1.67519165
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.67048234
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66328440
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65727400
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62329147
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61218090
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60274701
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60004961
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.57896754
47RACK7_27058665_Chip-Seq_MCF-7_Human1.55858347
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55207674
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54096451
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52581742
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50871871
52AHR_22903824_ChIP-Seq_MCF-7_Human1.49381128
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48219411
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47733818
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.47615009
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.46988871
57* LXR_22158963_ChIP-Seq_LIVER_Mouse1.44435869
58* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43713289
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43204460
60GBX2_23144817_ChIP-Seq_PC3_Human1.42165030
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41657863
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41495782
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.40754924
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39779884
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39777547
66MYC_22102868_ChIP-Seq_BL_Human1.38119054
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36926445
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36402931
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36395982
70ZNF274_21170338_ChIP-Seq_K562_Hela1.35861059
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35838673
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35759433
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35185662
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35112016
75* GATA4_25053715_ChIP-Seq_YYC3_Human1.35097652
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34438492
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34421658
78* REST_21632747_ChIP-Seq_MESCs_Mouse1.33289035
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32840570
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32179071
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30631178
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30312859
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30270024
84VDR_21846776_ChIP-Seq_THP-1_Human1.30218675
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30139176
86SMC4_20622854_ChIP-Seq_HELA_Human1.29487173
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28471056
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.28267133
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28128550
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28007956
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.27997695
92STAT3_23295773_ChIP-Seq_U87_Human1.27151839
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.27141428
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.26385114
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25544680
96CREB1_26743006_Chip-Seq_LNCaP_Human1.25499848
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25287265
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24140711
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.23579781
100FOXA1_25552417_ChIP-Seq_VCAP_Human1.23566123
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.23563484
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23481840
103XRN2_22483619_ChIP-Seq_HELA_Human1.23366263
104* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23294262
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.22725050
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22627433
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22466977
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22016847
109SOX3_22085726_ChIP-Seq_NPCs_Mouse1.21481089
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21321618
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.20744205
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20711018
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20498758
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19552954
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.18462316
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.17892063
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.17810304
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.17317975
119* KAP1_27257070_Chip-Seq_ESCs_Mouse1.17222531
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17075767
121TCF7_22412390_ChIP-Seq_EML_Mouse1.17042739
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16716552
123* P68_20966046_ChIP-Seq_HELA_Human1.16180669
124* GATA6_25053715_ChIP-Seq_YYC3_Human1.16088900
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15986196
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15386829
127* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14475587
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14008202
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.13701600
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13440687
131* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13177619
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.12616406
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12258781
134KLF4_18555785_Chip-Seq_ESCs_Mouse1.11887013
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11621202
136P53_22387025_ChIP-Seq_ESCs_Mouse1.10925844
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10714613
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10414338
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09945043
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09667286
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09541796
142NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09376804
143EZH2_22144423_ChIP-Seq_EOC_Human1.09358600
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08356291
145POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08315341
146SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07679573
147ZNF263_19887448_ChIP-Seq_K562_Human1.07394869
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07144665
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06816270
150PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06475378
151CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06324934
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06204101
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05922444
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05798074
155ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05020536
156TBL1_22424771_ChIP-Seq_293T_Human1.04714005
157* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04096155
158POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03928331
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03764359
160MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03280276
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03273375
162PU1_27457419_Chip-Seq_LIVER_Mouse1.02918867
163ZFX_18555785_Chip-Seq_ESCs_Mouse1.02849838
164P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02786656
165P300_18555785_Chip-Seq_ESCs_Mouse1.02421227
166* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02380426
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02099622
168ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01762459
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01180104
170SMAD3_21741376_ChIP-Seq_HESCs_Human1.00584635
171CMYC_18555785_Chip-Seq_ESCs_Mouse1.00533370
172CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99929646
173* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99868942
174ETV1_20927104_ChIP-Seq_GIST48_Human0.98084733
175KDM5A_27292631_Chip-Seq_BREAST_Human0.97502440
176CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97051184
177POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96528319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.14758771
2MP0003136_yellow_coat_color3.56471473
3MP0008260_abnormal_autophagy3.16668366
4MP0003183_abnormal_peptide_metabolism3.13260273
5MP0004264_abnormal_extraembryonic_tissu3.06546320
6MP0009840_abnormal_foam_cell2.94867568
7MP0003122_maternal_imprinting2.86825839
8MP0003693_abnormal_embryo_hatching2.85791405
9MP0005365_abnormal_bile_salt2.84279256
10MP0003123_paternal_imprinting2.84145620
11MP0003718_maternal_effect2.80362832
12MP0002138_abnormal_hepatobiliary_system2.62307539
13MP0005409_darkened_coat_color2.56036791
14MP0002139_abnormal_hepatobiliary_system2.54078301
15MP0001666_abnormal_nutrient_absorption2.39491578
16MP0004043_abnormal_pH_regulation2.30499960
17MP0005085_abnormal_gallbladder_physiolo2.27353615
18MP0000537_abnormal_urethra_morphology2.23699091
19MP0005220_abnormal_exocrine_pancreas2.23190994
20MP0004019_abnormal_vitamin_homeostasis2.21187911
21MP0002089_abnormal_postnatal_growth/wei2.09396656
22MP0003172_abnormal_lysosome_physiology2.08782541
23MP0010386_abnormal_urinary_bladder2.06988593
24MP0003878_abnormal_ear_physiology2.04627508
25MP0005377_hearing/vestibular/ear_phenot2.04627508
26MP0005310_abnormal_salivary_gland2.04229948
27MP0008057_abnormal_DNA_replication2.01902954
28MP0003111_abnormal_nucleus_morphology1.98531648
29MP0005076_abnormal_cell_differentiation1.91834404
30MP0005379_endocrine/exocrine_gland_phen1.91582140
31MP0004885_abnormal_endolymph1.90755058
32MP0000462_abnormal_digestive_system1.89213122
33MP0002254_reproductive_system_inflammat1.75987176
34MP0001944_abnormal_pancreas_morphology1.73535988
35MP0002693_abnormal_pancreas_physiology1.66441066
36MP0001188_hyperpigmentation1.65969535
37MP0001502_abnormal_circadian_rhythm1.65191357
38MP0003329_amyloid_beta_deposits1.62463164
39MP0001756_abnormal_urination1.52458318
40MP0006292_abnormal_olfactory_placode1.52229339
41MP0003786_premature_aging1.48587291
42MP0001485_abnormal_pinna_reflex1.44675195
43MP0008058_abnormal_DNA_repair1.44230755
44MP0005408_hypopigmentation1.43635101
45MP0001529_abnormal_vocalization1.40453886
46MP0008995_early_reproductive_senescence1.38387245
47MP0001661_extended_life_span1.37030026
48MP0003252_abnormal_bile_duct1.34673854
49MP0002876_abnormal_thyroid_physiology1.34478645
50MP0004185_abnormal_adipocyte_glucose1.34033720
51MP0001765_abnormal_ion_homeostasis1.32715299
52MP0003195_calcinosis1.30895132
53MP0008877_abnormal_DNA_methylation1.28551140
54MP0003868_abnormal_feces_composition1.27882409
55MP0005332_abnormal_amino_acid1.27746694
56MP0005395_other_phenotype1.26663724
57MP0003121_genomic_imprinting1.25389633
58MP0002009_preneoplasia1.25354101
59MP0003879_abnormal_hair_cell1.21488999
60MP0002163_abnormal_gland_morphology1.15842306
61MP0001324_abnormal_eye_pigmentation1.15107832
62MP0005248_abnormal_Harderian_gland1.14644089
63MP0003890_abnormal_embryonic-extraembry1.14089567
64MP0001440_abnormal_grooming_behavior1.13848316
65MP0008961_abnormal_basal_metabolism1.13428461
66MP0005360_urolithiasis1.13137064
67MP0003806_abnormal_nucleotide_metabolis1.12519010
68MP0005646_abnormal_pituitary_gland1.11855198
69MP0003690_abnormal_glial_cell1.09457611
70MP0010329_abnormal_lipoprotein_level1.09453991
71MP0000778_abnormal_nervous_system1.08835799
72MP0002102_abnormal_ear_morphology1.08511101
73MP0003632_abnormal_nervous_system1.07243869
74MP0005084_abnormal_gallbladder_morpholo1.07124209
75MP0001929_abnormal_gametogenesis1.06640443
76MP0003880_abnormal_central_pattern1.05966818
77MP0001730_embryonic_growth_arrest1.05619820
78MP0002928_abnormal_bile_duct1.05301305
79MP0005666_abnormal_adipose_tissue1.03919925
80MP0009379_abnormal_foot_pigmentation1.02502836
81MP0005647_abnormal_sex_gland1.01438103
82MP0004270_analgesia1.00926457
83MP0001501_abnormal_sleep_pattern0.99866446
84MP0000920_abnormal_myelination0.99673040
85MP0003634_abnormal_glial_cell0.99340533
86MP0002735_abnormal_chemical_nociception0.98957136
87MP0003953_abnormal_hormone_level0.97534133
88MP0010094_abnormal_chromosome_stability0.96772376
89MP0003698_abnormal_male_reproductive0.96386317
90MP0003283_abnormal_digestive_organ0.96294974
91MP0010678_abnormal_skin_adnexa0.95937223
92MP0004957_abnormal_blastocyst_morpholog0.95386009
93MP0001764_abnormal_homeostasis0.94684903
94MP0004742_abnormal_vestibular_system0.94045573
95MP0009046_muscle_twitch0.93880929
96MP0000613_abnormal_salivary_gland0.93813656
97MP0000371_diluted_coat_color0.93185534
98MP0002064_seizures0.92804232
99MP0008875_abnormal_xenobiotic_pharmacok0.92441818
100MP0005451_abnormal_body_composition0.92383052
101MP0009780_abnormal_chondrocyte_physiolo0.91913631
102MP0009643_abnormal_urine_homeostasis0.91582846
103MP0001145_abnormal_male_reproductive0.91389681
104* MP0002118_abnormal_lipid_homeostasis0.91011689
105MP0002078_abnormal_glucose_homeostasis0.90617000
106MP0002909_abnormal_adrenal_gland0.89820557
107MP0001881_abnormal_mammary_gland0.89652933
108MP0005636_abnormal_mineral_homeostasis0.87377504
109MP0003699_abnormal_female_reproductive0.87137524
110MP0000604_amyloidosis0.85978592
111MP0003115_abnormal_respiratory_system0.85892265
112MP0002733_abnormal_thermal_nociception0.85877809
113MP0002697_abnormal_eye_size0.85145094
114MP0001697_abnormal_embryo_size0.85093720
115MP0000538_abnormal_urinary_bladder0.85048647
116MP0002822_catalepsy0.85000925
117MP0003315_abnormal_perineum_morphology0.84684462
118MP0010234_abnormal_vibrissa_follicle0.84642244
119MP0009703_decreased_birth_body0.84568728
120MP0000653_abnormal_sex_gland0.83852940
121MP0001915_intracranial_hemorrhage0.83839856
122MP0003077_abnormal_cell_cycle0.83691139
123MP0001672_abnormal_embryogenesis/_devel0.83688236
124MP0005380_embryogenesis_phenotype0.83688236
125MP0003191_abnormal_cellular_cholesterol0.82392780
126MP0000955_abnormal_spinal_cord0.81860546
127MP0002249_abnormal_larynx_morphology0.81766743
128MP0005410_abnormal_fertilization0.81702684
129MP0002653_abnormal_ependyma_morphology0.81595434
130MP0003861_abnormal_nervous_system0.81437839
131MP0002092_abnormal_eye_morphology0.81138914
132MP0006072_abnormal_retinal_apoptosis0.80294073
133MP0000627_abnormal_mammary_gland0.80210742
134MP0004859_abnormal_synaptic_plasticity0.79586023
135MP0002210_abnormal_sex_determination0.79560620
136MP0005058_abnormal_lysosome_morphology0.79540878
137MP0005083_abnormal_biliary_tract0.79229546
138MP0003119_abnormal_digestive_system0.79175971
139MP0003984_embryonic_growth_retardation0.78751216
140MP0002734_abnormal_mechanical_nocicepti0.78094980
141MP0002152_abnormal_brain_morphology0.76815568
142MP0003943_abnormal_hepatobiliary_system0.76666837
143MP0002638_abnormal_pupillary_reflex0.76396243
144MP0000678_abnormal_parathyroid_gland0.75566236
145MP0002088_abnormal_embryonic_growth/wei0.75255795
146MP0002090_abnormal_vision0.74767510
147MP0000383_abnormal_hair_follicle0.74427383
148MP0002277_abnormal_respiratory_mucosa0.73813358
149* MP0000609_abnormal_liver_physiology0.73541942
150MP0005448_abnormal_energy_balance0.72321759
151MP0002084_abnormal_developmental_patter0.71835682
152* MP0002080_prenatal_lethality0.71818408
153MP0001486_abnormal_startle_reflex0.71438895
154MP0002229_neurodegeneration0.71356161
155MP0009672_abnormal_birth_weight0.71347672
156MP0002161_abnormal_fertility/fecundity0.70728703
157MP0002938_white_spotting0.70624116
158MP0003567_abnormal_fetal_cardiomyocyte0.68324668
159MP0002075_abnormal_coat/hair_pigmentati0.67758507

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)4.82352886
2Deep venous thrombosis (HP:0002625)4.48203453
3Hyperglycinemia (HP:0002154)4.39755365
4Impulsivity (HP:0100710)4.01277724
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91091216
6Hyperglycinuria (HP:0003108)3.59755129
7Hyperglycemia (HP:0003074)3.58018186
8Hypobetalipoproteinemia (HP:0003563)3.54497197
9Entropion (HP:0000621)3.37531809
10Partial duplication of thumb phalanx (HP:0009944)3.28442547
11Hyperactive renin-angiotensin system (HP:0000841)3.13408057
12Insulin-resistant diabetes mellitus (HP:0000831)2.98028825
13Birth length less than 3rd percentile (HP:0003561)2.92596608
14Submucous cleft hard palate (HP:0000176)2.91456973
15Decreased circulating renin level (HP:0003351)2.89751110
16Aplasia involving bones of the extremities (HP:0009825)2.87975634
17Aplasia involving bones of the upper limbs (HP:0009823)2.87975634
18Aplasia of the phalanges of the hand (HP:0009802)2.87975634
19Abnormal tarsal ossification (HP:0008369)2.84531773
20Oligodactyly (hands) (HP:0001180)2.82962695
21Confusion (HP:0001289)2.75600037
22Abnormality of serine family amino acid metabolism (HP:0010894)2.72040621
23Abnormality of glycine metabolism (HP:0010895)2.72040621
24Symptomatic seizures (HP:0011145)2.70858741
25Broad alveolar ridges (HP:0000187)2.69194145
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67189288
27Vascular calcification (HP:0004934)2.66708624
28Ureteral duplication (HP:0000073)2.64997576
29Hypoglycemic seizures (HP:0002173)2.63785931
30Hyperinsulinemic hypoglycemia (HP:0000825)2.57133508
31Bifid scrotum (HP:0000048)2.55439609
32Breast hypoplasia (HP:0003187)2.54323036
33Bronchomalacia (HP:0002780)2.52861864
34Neurofibrillary tangles (HP:0002185)2.52490768
35Segmental peripheral demyelination/remyelination (HP:0003481)2.51831102
36Abnormality of the lumbar spine (HP:0100712)2.50780592
37Overlapping toe (HP:0001845)2.50127352
38Hepatoblastoma (HP:0002884)2.48164978
39Complement deficiency (HP:0004431)2.48135744
40Flat acetabular roof (HP:0003180)2.47174351
41Hyperkalemia (HP:0002153)2.46502561
42Dysautonomia (HP:0002459)2.45642452
43Glucose intolerance (HP:0000833)2.44709502
44Tetraplegia (HP:0002445)2.44008090
45Split foot (HP:0001839)2.40055697
46Pancreatic fibrosis (HP:0100732)2.39829203
47Glomerulonephritis (HP:0000099)2.37612783
48Increased nuchal translucency (HP:0010880)2.36237965
49Turricephaly (HP:0000262)2.36164520
50Abnormal pancreas size (HP:0012094)2.35513166
51Thickened helices (HP:0000391)2.32890669
52Alacrima (HP:0000522)2.32398939
53Partial duplication of the phalanx of hand (HP:0009999)2.31233403
54Xanthomatosis (HP:0000991)2.31224544
5511 pairs of ribs (HP:0000878)2.27030755
56Increased purine levels (HP:0004368)2.26830417
57Hyperuricemia (HP:0002149)2.26830417
58Chromsome breakage (HP:0040012)2.25940360
59Restlessness (HP:0000711)2.24621871
60Anal stenosis (HP:0002025)2.24539122
61Flat capital femoral epiphysis (HP:0003370)2.23048682
62Increased circulating renin level (HP:0000848)2.19296478
63Facial hemangioma (HP:0000329)2.19054345
64Megaloblastic anemia (HP:0001889)2.18950616
65Hypoplastic nipples (HP:0002557)2.18589437
66Absent radius (HP:0003974)2.15570070
67Facial shape deformation (HP:0011334)2.14904153
68Potter facies (HP:0002009)2.14904153
69Joint hemorrhage (HP:0005261)2.14620612
70Alopecia of scalp (HP:0002293)2.14515067
71Spinal muscular atrophy (HP:0007269)2.12211047
72Chronic bronchitis (HP:0004469)2.11628818
73Stomach cancer (HP:0012126)2.11541118
74Abnormality of carpal bone ossification (HP:0006257)2.11051134
75Capillary hemangiomas (HP:0005306)2.10074692
76Absent forearm bone (HP:0003953)2.10008297
77Aplasia involving forearm bones (HP:0009822)2.10008297
78Supranuclear gaze palsy (HP:0000605)2.09835042
79Abnormality of serum amino acid levels (HP:0003112)2.08706183
80Vaginal fistula (HP:0004320)2.06269039
81Choanal stenosis (HP:0000452)2.05663617
82Hypolipoproteinemia (HP:0010981)2.05066529
83Conjugated hyperbilirubinemia (HP:0002908)2.03224224
84Pustule (HP:0200039)2.01588253
85Abnormality of permanent molar morphology (HP:0011071)1.99766238
86Abnormality of the dental root (HP:0006486)1.99766238
87Taurodontia (HP:0000679)1.99766238
88Cerebral inclusion bodies (HP:0100314)1.98472421
89Abnormal glucose tolerance (HP:0001952)1.98042506
90Paraparesis (HP:0002385)1.97186322
91Hypercholesterolemia (HP:0003124)1.96983166
92Sex reversal (HP:0012245)1.96615519
93Abnormal sex determination (HP:0012244)1.96615519
94Cheilitis (HP:0100825)1.95235831
95Protruding tongue (HP:0010808)1.95149889
96Pancreatic cysts (HP:0001737)1.94430558
97Anteriorly placed anus (HP:0001545)1.94144314
98Systemic lupus erythematosus (HP:0002725)1.93627820
99Hypophosphatemic rickets (HP:0004912)1.93213342
100Retinal atrophy (HP:0001105)1.91570311
101Abnormal spermatogenesis (HP:0008669)1.90834497
102Abnormality of DNA repair (HP:0003254)1.90484063
103Male infertility (HP:0003251)1.90039936
104Hemorrhage of the eye (HP:0011885)1.87573257
105Hemangiomatosis (HP:0007461)1.87489100
106Visceral angiomatosis (HP:0100761)1.86811569
107Ventricular fibrillation (HP:0001663)1.86312475
108Short nail (HP:0001799)1.86179079
109Hyperaldosteronism (HP:0000859)1.86042552
110Hypotension (HP:0002615)1.85801213
111Neuronal loss in central nervous system (HP:0002529)1.85156342
112Azoospermia (HP:0000027)1.84620332
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84526933
114Pathologic fracture (HP:0002756)1.84434061
115Aplasia/hypoplasia of the uterus (HP:0008684)1.83599564
116Abnormality of purine metabolism (HP:0004352)1.83557599
117Peripheral hypomyelination (HP:0007182)1.83192629
118Genetic anticipation (HP:0003743)1.82975904
119Abnormality of homocysteine metabolism (HP:0010919)1.82966925
120Homocystinuria (HP:0002156)1.82966925
121Shawl scrotum (HP:0000049)1.82196560
122Hyperphosphatemia (HP:0002905)1.82077618
123Heterotopia (HP:0002282)1.81788237
124Abnormality of renin-angiotensin system (HP:0000847)1.81741381
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81520544
126Flattened epiphyses (HP:0003071)1.81321079
127Abnormal biliary tract morphology (HP:0012440)1.79999644
128Progressive muscle weakness (HP:0003323)1.78958518
129Duplication of thumb phalanx (HP:0009942)1.78863897
130Pigmentary retinal degeneration (HP:0001146)1.78684995
131Bundle branch block (HP:0011710)1.77500837
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76932695
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76590567
134Absent epiphyses (HP:0010577)1.76590567
135Nuclear cataract (HP:0100018)1.76137955
136Short clavicles (HP:0000894)1.75503027
137Overriding aorta (HP:0002623)1.75298158
138Cardiovascular calcification (HP:0011915)1.74981321
139Prolonged partial thromboplastin time (HP:0003645)1.74843628
140Sparse lateral eyebrow (HP:0005338)1.74804748
141Abnormal hand bone ossification (HP:0010660)1.74498685
142Abnormal foot bone ossification (HP:0010675)1.74345682
143Global brain atrophy (HP:0002283)1.73994255
144Abnormality of the intrinsic pathway (HP:0010989)1.72609388
145Oligodactyly (HP:0012165)1.71378385
146Abnormality of the vitreous humor (HP:0004327)1.71211221
147Abnormal ossification of hand bones (HP:0005921)1.70647543
148Epiphyseal dysplasia (HP:0002656)1.69444679
149Median cleft lip (HP:0000161)1.69340629
150Hypoplasia of dental enamel (HP:0006297)1.69031926
151Tubulointerstitial nephritis (HP:0001970)1.68756722
152Fat malabsorption (HP:0002630)1.67771737
153Generalized hypotonia (HP:0001290)1.67648486
154Arnold-Chiari malformation (HP:0002308)1.67601841
155Increased serum pyruvate (HP:0003542)1.67510014
156Spastic paraparesis (HP:0002313)1.67340750
157Abnormality of the dental pulp (HP:0006479)1.67125555
158Gonadal dysgenesis (HP:0000133)1.66906480
159Supernumerary ribs (HP:0005815)1.66554521
160Vertebral arch anomaly (HP:0008438)1.66245652
161Abnormality of glycolysis (HP:0004366)1.65784888
162Excessive salivation (HP:0003781)1.64696711
163Drooling (HP:0002307)1.64696711
164Intrahepatic cholestasis (HP:0001406)1.64694111
165Abnormality of complement system (HP:0005339)1.63361919
166Abnormality of the preputium (HP:0100587)1.63181520
167Vitreoretinal degeneration (HP:0000655)1.63108349
168Abnormality of chloride homeostasis (HP:0011422)1.62676077
169Broad distal phalanx of finger (HP:0009836)1.62185399
170Small epiphyses (HP:0010585)1.62133780
171Scanning speech (HP:0002168)1.61761846
172Osteomalacia (HP:0002749)1.61697114
173Thoracic kyphosis (HP:0002942)1.60692388
174Aplasia/Hypoplasia of the uvula (HP:0010293)1.60442833
175Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60256928
176Aplasia/Hypoplasia of the sternum (HP:0006714)1.60138160
177Abnormality of the axillary hair (HP:0100134)1.59964534
178Abnormality of secondary sexual hair (HP:0009888)1.59964534
179Abnormality of the renal cortex (HP:0011035)1.59592252
180Hypoplasia of the uterus (HP:0000013)1.59339786
181Aggressive behavior (HP:0000718)1.59249326
182Pancreatic islet-cell hyperplasia (HP:0004510)1.58149372
183Leiomyosarcoma (HP:0100243)1.58078266
184Uterine leiomyosarcoma (HP:0002891)1.58078266
185Death in infancy (HP:0001522)1.57854297
186Abnormality of the common coagulation pathway (HP:0010990)1.56895991
187Megalencephaly (HP:0001355)1.56662169
188Meckel diverticulum (HP:0002245)1.56185605
189Rickets (HP:0002748)1.56100989
190Abnormality of molar (HP:0011077)1.55294024
191Abnormality of molar morphology (HP:0011070)1.55294024
192Hyperthyroidism (HP:0000836)1.55126464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.10136699
2EPHA24.14558263
3INSRR3.68433968
4MAPK153.68072885
5FGFR22.97119343
6ZAK2.34567154
7FRK2.18331447
8WEE12.15714971
9IRAK32.10357003
10MKNK22.06325490
11CAMK1G2.02437563
12FGFR31.99750077
13SIK11.98876354
14BUB11.97634021
15TAOK31.96771775
16TRIB31.87608868
17TSSK61.86226683
18STK391.78796369
19WNK31.77032799
20LATS11.69790377
21LATS21.68529764
22TAOK11.67175287
23TYRO31.66086524
24NTRK31.62521088
25BRD41.61541864
26TNIK1.61502081
27EIF2AK31.53534325
28PINK11.53333173
29BRSK21.51831644
30NEK21.47055227
31NUAK11.43677985
32UHMK11.41320642
33STK161.37404076
34MST1R1.36836792
35NEK61.33769779
36PNCK1.33333826
37ALK1.32943565
38OXSR11.30855157
39SIK21.21992947
40MINK11.19288677
41MET1.18561541
42STK38L1.18179040
43EEF2K1.17106247
44EPHA41.16858569
45TTK1.16732110
46PRKD31.16731187
47MARK31.14344010
48PLK41.14072346
49ACVR1B1.12953625
50NME21.11649919
51BRAF1.09623337
52SMG11.08316526
53MAP3K111.08282825
54ERN11.07822013
55FGR1.07072208
56FGFR11.06601437
57CDK121.02901217
58PRKCI1.02380780
59CDK191.02361309
60PDPK11.01899262
61STK31.01812456
62DYRK31.00734996
63MAP3K100.99975736
64EPHA30.99437519
65PTK60.97595881
66MAP3K90.96725910
67CHEK20.95788304
68PLK30.95404505
69MAP2K20.94428751
70CDC70.93575107
71EIF2AK20.90920522
72CDK30.90211423
73PLK10.89968051
74STK380.88437056
75MAP3K20.85341610
76CDK70.81123479
77RPS6KB20.80599534
78RIPK40.80505425
79SGK20.79982218
80WNK40.79947723
81SRPK10.77623887
82NTRK20.77085516
83RET0.76856635
84PDK20.76218344
85PRKAA10.75243204
86PIK3CG0.74598813
87DMPK0.73586191
88CHUK0.70812593
89MAP3K10.68927253
90ARAF0.67155506
91BRSK10.66062084
92CDK60.65614344
93EPHB10.60853103
94CAMKK20.60790687
95MKNK10.60034778
96IRAK20.59421912
97CDK11A0.59292009
98PDK10.58603405
99DYRK1A0.58080303
100MATK0.57275477
101PTK20.57004493
102ERBB20.56383958
103PBK0.55788649
104IRAK10.55392706
105STK110.54284723
106FER0.54227786
107CDK150.53181628
108RIPK10.53130883
109MTOR0.52622467
110CDK10.52447250
111MAP2K40.51661643
112MARK20.51589253
113CDK40.51395794
114CSNK1E0.50965715
115YES10.50270228
116AKT20.49506287
117WNK10.48835345
118PRKAA20.48798238
119CSNK1A10.46967535
120MAP3K80.46887913
121MAPK100.46848709
122CSF1R0.46715557
123AURKB0.45827222
124CDK180.45608519
125PASK0.45064051
126ICK0.43931452
127SGK4940.43546924
128SGK2230.43546924
129CDK50.42960765
130BMPR1B0.42494443
131CDK140.42261900
132SGK30.41621352
133DYRK1B0.41079166
134NLK0.39531802
135DAPK20.39530894
136PRKCG0.38746721
137SGK10.38262985
138MST40.37681406
139FGFR40.37553639
140PRKCE0.37405096
141EIF2AK10.36699928
142CAMK1D0.35972687
143GSK3B0.34554759
144CSNK1A1L0.34309207
145GRK10.33968554
146ERBB40.33047992
147CDK20.31643383
148CDC42BPA0.30101536
149CSNK1G20.29678701
150CHEK10.29635363
151MAP3K130.29322782

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.38516810
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.80550056
3Vitamin digestion and absorption_Homo sapiens_hsa049773.42036660
4Folate biosynthesis_Homo sapiens_hsa007903.06007053
5Other glycan degradation_Homo sapiens_hsa005112.73550208
6Regulation of autophagy_Homo sapiens_hsa041402.67473552
7Circadian rhythm_Homo sapiens_hsa047102.36031898
8Complement and coagulation cascades_Homo sapiens_hsa046102.28998888
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26601554
10* Glycerophospholipid metabolism_Homo sapiens_hsa005641.99324185
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96984253
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93084034
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89522851
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85351429
15Fatty acid metabolism_Homo sapiens_hsa012121.75460738
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73109524
17RNA polymerase_Homo sapiens_hsa030201.68481480
18PPAR signaling pathway_Homo sapiens_hsa033201.65301303
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64857156
20Fatty acid degradation_Homo sapiens_hsa000711.63170854
21Nicotine addiction_Homo sapiens_hsa050331.60320021
22Pyruvate metabolism_Homo sapiens_hsa006201.59773367
23Mineral absorption_Homo sapiens_hsa049781.58637039
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57363018
25Renin-angiotensin system_Homo sapiens_hsa046141.57296234
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53705372
27Selenocompound metabolism_Homo sapiens_hsa004501.52479461
28Fat digestion and absorption_Homo sapiens_hsa049751.42868966
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42620519
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34274500
31Insulin secretion_Homo sapiens_hsa049111.30260928
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28414170
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27741197
34Phenylalanine metabolism_Homo sapiens_hsa003601.27046822
35Type II diabetes mellitus_Homo sapiens_hsa049301.23348331
36Biosynthesis of amino acids_Homo sapiens_hsa012301.22207465
37Propanoate metabolism_Homo sapiens_hsa006401.21395872
38Carbon metabolism_Homo sapiens_hsa012001.20979822
39Tyrosine metabolism_Homo sapiens_hsa003501.20145514
40Sphingolipid metabolism_Homo sapiens_hsa006001.18279791
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17641852
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16704978
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.16522279
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14975205
45Prion diseases_Homo sapiens_hsa050201.14535871
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13870383
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12800680
48Taste transduction_Homo sapiens_hsa047421.11131227
49Fatty acid biosynthesis_Homo sapiens_hsa000611.07845264
50Fanconi anemia pathway_Homo sapiens_hsa034601.07378647
51Glutathione metabolism_Homo sapiens_hsa004801.04568147
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.03752824
53Amphetamine addiction_Homo sapiens_hsa050311.03621139
54ABC transporters_Homo sapiens_hsa020100.99883537
55Protein export_Homo sapiens_hsa030600.99097379
56Inositol phosphate metabolism_Homo sapiens_hsa005620.96492909
57Fructose and mannose metabolism_Homo sapiens_hsa000510.95918125
58Dorso-ventral axis formation_Homo sapiens_hsa043200.95860822
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95468464
60p53 signaling pathway_Homo sapiens_hsa041150.95403687
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95332737
62Pancreatic secretion_Homo sapiens_hsa049720.95280934
63Lysosome_Homo sapiens_hsa041420.94450669
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91282789
65beta-Alanine metabolism_Homo sapiens_hsa004100.88155776
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.84928810
67RNA transport_Homo sapiens_hsa030130.84652221
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.82898387
69Glucagon signaling pathway_Homo sapiens_hsa049220.82085401
70N-Glycan biosynthesis_Homo sapiens_hsa005100.80473366
71Notch signaling pathway_Homo sapiens_hsa043300.79774745
72Glycerolipid metabolism_Homo sapiens_hsa005610.79594026
73Fatty acid elongation_Homo sapiens_hsa000620.79409881
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78517309
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77430645
76Purine metabolism_Homo sapiens_hsa002300.76133147
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75147722
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72254751
79Basal transcription factors_Homo sapiens_hsa030220.71668961
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71466965
81Chemical carcinogenesis_Homo sapiens_hsa052040.70273652
82Spliceosome_Homo sapiens_hsa030400.69510284
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68639324
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67690516
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.64790472
86Tight junction_Homo sapiens_hsa045300.61799283
87Cocaine addiction_Homo sapiens_hsa050300.61642484
88Galactose metabolism_Homo sapiens_hsa000520.61277662
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60778553
90Lysine degradation_Homo sapiens_hsa003100.60580291
91Glutamatergic synapse_Homo sapiens_hsa047240.59586851
92DNA replication_Homo sapiens_hsa030300.59258399
93Peroxisome_Homo sapiens_hsa041460.58994900
94Protein digestion and absorption_Homo sapiens_hsa049740.58751238
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.58365980
96Linoleic acid metabolism_Homo sapiens_hsa005910.58200067
97Long-term potentiation_Homo sapiens_hsa047200.57411995
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57144377
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57064652
100Circadian entrainment_Homo sapiens_hsa047130.56965750
101Adherens junction_Homo sapiens_hsa045200.56938768
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56710534
103Pyrimidine metabolism_Homo sapiens_hsa002400.56178485
104Hippo signaling pathway_Homo sapiens_hsa043900.56101783
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55117352
106Wnt signaling pathway_Homo sapiens_hsa043100.54905625
107Homologous recombination_Homo sapiens_hsa034400.54858046
108Cell cycle_Homo sapiens_hsa041100.54428328
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54377443
110ErbB signaling pathway_Homo sapiens_hsa040120.54304776
111Bile secretion_Homo sapiens_hsa049760.54077700
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54062498
113mTOR signaling pathway_Homo sapiens_hsa041500.52365264
114Arginine and proline metabolism_Homo sapiens_hsa003300.51647350
115Endometrial cancer_Homo sapiens_hsa052130.50496602
116Arginine biosynthesis_Homo sapiens_hsa002200.50405447
117FoxO signaling pathway_Homo sapiens_hsa040680.49825850
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48622251
119Melanogenesis_Homo sapiens_hsa049160.47662349
120Basal cell carcinoma_Homo sapiens_hsa052170.47092807
121Prostate cancer_Homo sapiens_hsa052150.46810328
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46281858
123AMPK signaling pathway_Homo sapiens_hsa041520.45870064
124GABAergic synapse_Homo sapiens_hsa047270.44669610
125Synaptic vesicle cycle_Homo sapiens_hsa047210.44552994
126mRNA surveillance pathway_Homo sapiens_hsa030150.44273863
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.43587045
128Sulfur metabolism_Homo sapiens_hsa009200.41307427
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40893250
130Oocyte meiosis_Homo sapiens_hsa041140.40051350
131Collecting duct acid secretion_Homo sapiens_hsa049660.39407399
132Vibrio cholerae infection_Homo sapiens_hsa051100.39253306
133Mismatch repair_Homo sapiens_hsa034300.38878201
134Steroid biosynthesis_Homo sapiens_hsa001000.36312379
135Ether lipid metabolism_Homo sapiens_hsa005650.35854444
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.35548099
137Starch and sucrose metabolism_Homo sapiens_hsa005000.34814444
138Nitrogen metabolism_Homo sapiens_hsa009100.33054658
139Pentose phosphate pathway_Homo sapiens_hsa000300.32462541
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32345036
141Type I diabetes mellitus_Homo sapiens_hsa049400.32184964
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31732364
143Morphine addiction_Homo sapiens_hsa050320.31581504
144Butanoate metabolism_Homo sapiens_hsa006500.31342901
145Tryptophan metabolism_Homo sapiens_hsa003800.30484768
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28564678
147Thyroid hormone synthesis_Homo sapiens_hsa049180.27863674
148Histidine metabolism_Homo sapiens_hsa003400.27725579
149Retinol metabolism_Homo sapiens_hsa008300.27077214
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26841715
151Caffeine metabolism_Homo sapiens_hsa002320.26526468
152Estrogen signaling pathway_Homo sapiens_hsa049150.25913830
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25446293
154cAMP signaling pathway_Homo sapiens_hsa040240.23839827

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