CHKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.34490691
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34490691
3fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87526853
4L-phenylalanine catabolic process (GO:0006559)4.47518959
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47518959
6positive regulation by symbiont of host defense response (GO:0052509)4.40552125
7modulation by symbiont of host defense response (GO:0052031)4.40552125
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40552125
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40552125
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.40552125
11modulation by symbiont of host immune response (GO:0052553)4.40552125
12detection of bacterium (GO:0016045)4.37004416
13detection of other organism (GO:0098543)4.30984367
14L-phenylalanine metabolic process (GO:0006558)4.24379133
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.24379133
16immunoglobulin mediated immune response (GO:0016064)4.19685792
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05770638
18alpha-linolenic acid metabolic process (GO:0036109)4.04559777
19regulation of B cell receptor signaling pathway (GO:0050855)4.04302581
20positive thymic T cell selection (GO:0045059)3.94323236
21response to peptidoglycan (GO:0032494)3.94020217
22macrophage activation involved in immune response (GO:0002281)3.91848649
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91832142
24fatty acid beta-oxidation (GO:0006635)3.88474744
25regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86353147
26positive regulation of gamma-delta T cell activation (GO:0046645)3.86312622
27regulation of triglyceride catabolic process (GO:0010896)3.84384448
28neutrophil activation involved in immune response (GO:0002283)3.83671754
29negative thymic T cell selection (GO:0045060)3.80915105
30valine metabolic process (GO:0006573)3.80392938
31aromatic amino acid family catabolic process (GO:0009074)3.80242016
32cellular extravasation (GO:0045123)3.79384520
33negative regulation of interleukin-12 production (GO:0032695)3.74925484
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70909061
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70909061
36response to muramyl dipeptide (GO:0032495)3.69758957
37negative T cell selection (GO:0043383)3.67017483
38lysine catabolic process (GO:0006554)3.64119407
39lysine metabolic process (GO:0006553)3.64119407
40leukocyte aggregation (GO:0070486)3.63422205
41regulation of interferon-beta biosynthetic process (GO:0045357)3.61545532
42defense response to protozoan (GO:0042832)3.57358299
43glyoxylate metabolic process (GO:0046487)3.55319203
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54135725
45regulation of antigen processing and presentation (GO:0002577)3.52433632
46fatty acid oxidation (GO:0019395)3.52233500
47positive regulation of antigen processing and presentation (GO:0002579)3.52033809
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.51777647
49fatty acid catabolic process (GO:0009062)3.51002414
50tryptophan catabolic process (GO:0006569)3.49564699
51indole-containing compound catabolic process (GO:0042436)3.49564699
52indolalkylamine catabolic process (GO:0046218)3.49564699
53phospholipid efflux (GO:0033700)3.47202696
54lipid oxidation (GO:0034440)3.46466889
55B cell receptor signaling pathway (GO:0050853)3.44973176
56response to type I interferon (GO:0034340)3.44397139
57detection of external biotic stimulus (GO:0098581)3.42991004
58type I interferon signaling pathway (GO:0060337)3.40520049
59cellular response to type I interferon (GO:0071357)3.40520049
60regulation of gamma-delta T cell differentiation (GO:0045586)3.40048839
61antigen processing and presentation of endogenous antigen (GO:0019883)3.38954018
62kynurenine metabolic process (GO:0070189)3.38690485
63thymic T cell selection (GO:0045061)3.38347745
642-oxoglutarate metabolic process (GO:0006103)3.38145274
65tryptophan metabolic process (GO:0006568)3.36235509
66T cell selection (GO:0045058)3.35170884
67amino-acid betaine metabolic process (GO:0006577)3.34930343
68germinal center formation (GO:0002467)3.33784945
69response to protozoan (GO:0001562)3.32887824
70high-density lipoprotein particle remodeling (GO:0034375)3.31806413
71NIK/NF-kappaB signaling (GO:0038061)3.28505566
72negative regulation of leukocyte mediated immunity (GO:0002704)3.27372187
73regulation of gamma-delta T cell activation (GO:0046643)3.25349659
74T cell migration (GO:0072678)3.25002221
75response to interleukin-15 (GO:0070672)3.24059048
76mannose metabolic process (GO:0006013)3.23558417
77carnitine shuttle (GO:0006853)3.23523147
78interferon-gamma-mediated signaling pathway (GO:0060333)3.23265497
79urea cycle (GO:0000050)3.21960709
80urea metabolic process (GO:0019627)3.21960709
81myeloid cell activation involved in immune response (GO:0002275)3.21394868
82positive T cell selection (GO:0043368)3.20582878
83fatty acid transmembrane transport (GO:1902001)3.20079029
84regulation of T cell tolerance induction (GO:0002664)3.19692134
85bile acid biosynthetic process (GO:0006699)3.18086387
86carnitine metabolic process (GO:0009437)3.18048386
87acylglycerol homeostasis (GO:0055090)3.17865765
88triglyceride homeostasis (GO:0070328)3.17865765
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17190280
90tricarboxylic acid metabolic process (GO:0072350)3.16968113
91negative regulation of T cell mediated immunity (GO:0002710)3.15578424
92detection of biotic stimulus (GO:0009595)3.13945209
93regulation of cholesterol homeostasis (GO:2000188)3.12742048
94monocarboxylic acid catabolic process (GO:0072329)3.12712322
95negative regulation of innate immune response (GO:0045824)3.11714806
96regulation of B cell differentiation (GO:0045577)3.10209187
97regulation of cholesterol esterification (GO:0010872)3.08272160
98intestinal cholesterol absorption (GO:0030299)3.07301842
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05873101
100reverse cholesterol transport (GO:0043691)3.05759657
101regulation of mast cell degranulation (GO:0043304)3.04815477
102regulation of tolerance induction (GO:0002643)3.04709666
103B cell mediated immunity (GO:0019724)3.04108590
104plasma lipoprotein particle assembly (GO:0034377)3.03673197
105response to host immune response (GO:0052572)3.03671872
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03671872
107sulfur amino acid catabolic process (GO:0000098)3.02797365
108positive regulation of lipoprotein lipase activity (GO:0051006)3.02756073
109positive regulation of triglyceride lipase activity (GO:0061365)3.02756073
110respiratory burst (GO:0045730)3.00315029
111phospholipid homeostasis (GO:0055091)2.99061184
112neutrophil activation (GO:0042119)2.97558978
113negative regulation of cytokine production involved in immune response (GO:0002719)2.96387303
114tolerance induction (GO:0002507)2.94741565
115nitrogen cycle metabolic process (GO:0071941)2.94258643
116regulation of sequestering of triglyceride (GO:0010889)2.94080100
117short-chain fatty acid metabolic process (GO:0046459)2.93899672
118protein carboxylation (GO:0018214)2.93509310
119peptidyl-glutamic acid carboxylation (GO:0017187)2.93509310
120positive regulation of triglyceride metabolic process (GO:0090208)2.91492208
121cellular response to interleukin-15 (GO:0071350)2.91133100
122microglial cell activation (GO:0001774)2.91103199
123ethanol oxidation (GO:0006069)2.90946315
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88938681
125granulocyte activation (GO:0036230)2.86072388
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86062330
127regulation of protein activation cascade (GO:2000257)2.85796089
128Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83429950
129macrophage activation (GO:0042116)2.83185897
130positive regulation of granulocyte differentiation (GO:0030854)2.82976105
131bile acid metabolic process (GO:0008206)2.82422461
132positive regulation of type 2 immune response (GO:0002830)2.82350226
133negative regulation of sterol transport (GO:0032372)2.81725537
134negative regulation of cholesterol transport (GO:0032375)2.81725537
135protein-lipid complex assembly (GO:0065005)2.81661276
136negative regulation of interleukin-6 production (GO:0032715)2.81502824
137cellular ketone body metabolic process (GO:0046950)2.81499151
138lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81324394
139positive regulation of B cell differentiation (GO:0045579)2.80892793
140regulation of regulatory T cell differentiation (GO:0045589)2.80632505
141biotin metabolic process (GO:0006768)2.80592548
142pyrimidine nucleoside catabolic process (GO:0046135)2.80448080
143plasma lipoprotein particle clearance (GO:0034381)2.80446466
144response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80174210
145response to host (GO:0075136)2.80174210
146response to host defenses (GO:0052200)2.80174210
147plasma lipoprotein particle remodeling (GO:0034369)2.79982748
148protein-lipid complex remodeling (GO:0034368)2.79982748
149macromolecular complex remodeling (GO:0034367)2.79982748
150negative regulation of alpha-beta T cell activation (GO:0046636)2.79322187
151regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78060271
152regulation of natural killer cell mediated immunity (GO:0002715)2.78060271
153regulation of alpha-beta T cell proliferation (GO:0046640)2.77824295
154branched-chain amino acid metabolic process (GO:0009081)2.77190051
155regulation of T-helper 2 cell differentiation (GO:0045628)2.76679612
156acetyl-CoA metabolic process (GO:0006084)2.76277828
157complement activation, alternative pathway (GO:0006957)2.75947300
158regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75231684
159regulation of triglyceride metabolic process (GO:0090207)2.75215918
160regulation of leukocyte degranulation (GO:0043300)2.74778186
161regulation of fatty acid oxidation (GO:0046320)2.73376836
162negative regulation of erythrocyte differentiation (GO:0045647)2.72614892
163regulation of mast cell activation involved in immune response (GO:0033006)2.72552577
164leukocyte degranulation (GO:0043299)2.71271647
165negative regulation of fatty acid biosynthetic process (GO:0045717)2.70578261
166detection of molecule of bacterial origin (GO:0032490)2.69717489
167positive regulation of triglyceride biosynthetic process (GO:0010867)2.69474928
168indolalkylamine metabolic process (GO:0006586)2.68136871
169regulation of complement activation (GO:0030449)2.67617063
170positive regulation of tolerance induction (GO:0002645)2.67005719
171branched-chain amino acid catabolic process (GO:0009083)2.65766715
172regulation of T-helper 1 cell differentiation (GO:0045625)2.65625413
173mast cell activation (GO:0045576)2.65330226
174oxaloacetate metabolic process (GO:0006107)2.65205426
175positive regulation of lipid catabolic process (GO:0050996)2.65141165
176antigen processing and presentation via MHC class Ib (GO:0002475)2.63245178
177positive regulation of fatty acid beta-oxidation (GO:0032000)2.62674208
178cholesterol efflux (GO:0033344)2.61651792
179alpha-amino acid catabolic process (GO:1901606)2.61564925
180aromatic amino acid family metabolic process (GO:0009072)2.61558881
181complement activation, classical pathway (GO:0006958)2.61557600
182organic acid catabolic process (GO:0016054)2.60323594
183carboxylic acid catabolic process (GO:0046395)2.60323594
184negative regulation of fibrinolysis (GO:0051918)2.59440696
185positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59288819
186carnitine transmembrane transport (GO:1902603)2.58564401
187coenzyme catabolic process (GO:0009109)2.56147128
188tyrosine metabolic process (GO:0006570)2.53970429
189plasma lipoprotein particle organization (GO:0071827)2.53761543
190regulation of fatty acid biosynthetic process (GO:0042304)2.53214416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.13357784
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.42117026
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.38688077
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14336289
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.07108541
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.36470709
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.14925207
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.06538422
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.04445237
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.54521289
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42696538
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33628558
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33566157
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33162660
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25379912
16SCL_19346495_ChIP-Seq_HPC-7_Human2.21777250
17GATA1_22025678_ChIP-Seq_K562_Human2.16329455
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16260211
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15370830
20KDM2B_26808549_Chip-Seq_DND41_Human2.06583679
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02384206
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01350705
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94294785
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90802154
25VDR_21846776_ChIP-Seq_THP-1_Human1.90373166
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87565362
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83247433
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79857507
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79792091
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79657463
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76325847
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71240763
33MAF_26560356_Chip-Seq_TH1_Human1.66646526
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66195060
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65934075
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.65369045
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65110413
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60969627
39MYC_22102868_ChIP-Seq_BL_Human1.60952959
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58735045
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.58216195
42RUNX_20019798_ChIP-Seq_JUKART_Human1.56693149
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54902719
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.54646347
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54000597
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48836242
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48488855
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47719046
49VDR_24763502_ChIP-Seq_THP-1_Human1.46791692
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.43967128
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41353209
52UTX_26944678_Chip-Seq_JUKART_Human1.41035736
53SPI1_23547873_ChIP-Seq_NB4_Human1.40742786
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.40404105
55MYB_26560356_Chip-Seq_TH1_Human1.38886273
56* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38286276
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37787398
58P68_20966046_ChIP-Seq_HELA_Human1.37548554
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36830793
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35785438
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.35736197
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35522402
63TCF7_22412390_ChIP-Seq_EML_Mouse1.34982804
64CLOCK_20551151_ChIP-Seq_293T_Human1.34515018
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33855554
66LXR_22292898_ChIP-Seq_THP-1_Human1.32117023
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31570826
68SPI1_23127762_ChIP-Seq_K562_Human1.30909400
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30869697
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28099176
71VDR_24787735_ChIP-Seq_THP-1_Human1.26667904
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.26460012
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21792971
74MYB_26560356_Chip-Seq_TH2_Human1.21775122
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21217536
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18715778
77SMC4_20622854_ChIP-Seq_HELA_Human1.17517271
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16298129
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15587566
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.15505745
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15036693
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13850071
83RACK7_27058665_Chip-Seq_MCF-7_Human1.13618560
84MAF_26560356_Chip-Seq_TH2_Human1.12750951
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.11286291
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.10623242
87BCL6_27268052_Chip-Seq_Bcells_Human1.10581544
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10436912
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.10274211
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09793122
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09429405
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08791115
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08347135
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08315206
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07484108
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06807874
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.06295364
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06146282
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05533937
100E2F1_20622854_ChIP-Seq_HELA_Human1.05312715
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04534907
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04425211
103BCOR_27268052_Chip-Seq_Bcells_Human1.03844418
104PU_27001747_Chip-Seq_BMDM_Mouse1.03728186
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02997706
106SA1_27219007_Chip-Seq_Bcells_Human1.02831094
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.02025136
108KDM2B_26808549_Chip-Seq_K562_Human1.01801312
109PHF8_20622854_ChIP-Seq_HELA_Human1.01700232
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00458523
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00438534
112NCOR1_26117541_ChIP-Seq_K562_Human1.00247743
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.99865193
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99858412
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99695747
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99682452
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99619991
118CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97988817
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97884422
120* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97667419
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97002619
122P300_27268052_Chip-Seq_Bcells_Human0.96341484
123DROSHA_22980978_ChIP-Seq_HELA_Human0.95313937
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94902871
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94391577
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94203418
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94120667
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93244998
129GATA1_19941826_ChIP-Seq_K562_Human0.92549769
130GATA3_27048872_Chip-Seq_THYMUS_Human0.92247146
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.91826918
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.91826918
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90253402
134CIITA_25753668_ChIP-Seq_RAJI_Human0.89642666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.65995733
2MP0005365_abnormal_bile_salt3.97400786
3MP0005360_urolithiasis3.91658411
4MP0005085_abnormal_gallbladder_physiolo3.32427284
5MP0003172_abnormal_lysosome_physiology2.80691468
6MP0009840_abnormal_foam_cell2.63227602
7MP0003191_abnormal_cellular_cholesterol2.46769601
8MP0008875_abnormal_xenobiotic_pharmacok2.43268288
9MP0003252_abnormal_bile_duct2.36257327
10MP0010329_abnormal_lipoprotein_level2.34670726
11MP0001835_abnormal_antigen_presentation2.23118308
12MP0003195_calcinosis2.20134319
13MP0000685_abnormal_immune_system2.14143906
14MP0003806_abnormal_nucleotide_metabolis2.03569192
15MP0001666_abnormal_nutrient_absorption2.00130917
16MP0005083_abnormal_biliary_tract1.98453764
17MP0002138_abnormal_hepatobiliary_system1.98223352
18MP0001533_abnormal_skeleton_physiology1.94290023
19MP0002837_dystrophic_cardiac_calcinosis1.88507877
20MP0003436_decreased_susceptibility_to1.88314143
21MP0008260_abnormal_autophagy1.87173973
22MP0004510_myositis1.81026189
23MP0001790_abnormal_immune_system1.78349585
24MP0005387_immune_system_phenotype1.78349585
25MP0000609_abnormal_liver_physiology1.77921577
26MP0003646_muscle_fatigue1.74295239
27MP0004130_abnormal_muscle_cell1.73853106
28MP0001800_abnormal_humoral_immune1.73841959
29MP0005670_abnormal_white_adipose1.72850897
30MP0005671_abnormal_response_to1.69532269
31MP0005464_abnormal_platelet_physiology1.66131033
32MP0003724_increased_susceptibility_to1.59169835
33MP0005332_abnormal_amino_acid1.58897502
34MP0001873_stomach_inflammation1.58732804
35MP0001853_heart_inflammation1.56339831
36MP0009785_altered_susceptibility_to1.56160149
37* MP0002118_abnormal_lipid_homeostasis1.54248097
38MP0005025_abnormal_response_to1.51778369
39MP0003763_abnormal_thymus_physiology1.50146088
40MP0000465_gastrointestinal_hemorrhage1.47144728
41MP0006036_abnormal_mitochondrial_physio1.43170001
42MP0004381_abnormal_hair_follicle1.42279387
43MP0002452_abnormal_antigen_presenting1.42228564
44MP0005310_abnormal_salivary_gland1.40967069
45* MP0005319_abnormal_enzyme/_coenzyme1.40539044
46MP0002723_abnormal_immune_serum1.40204726
47MP0002396_abnormal_hematopoietic_system1.38957988
48MP0002419_abnormal_innate_immunity1.38763252
49MP0008469_abnormal_protein_level1.36218666
50MP0005000_abnormal_immune_tolerance1.34299514
51MP0005584_abnormal_enzyme/coenzyme_acti1.32636725
52MP0009643_abnormal_urine_homeostasis1.32510055
53MP0002166_altered_tumor_susceptibility1.29109772
54MP0009764_decreased_sensitivity_to1.26545547
55MP0001819_abnormal_immune_cell1.25971966
56MP0002420_abnormal_adaptive_immunity1.25932401
57MP0002998_abnormal_bone_remodeling1.25320309
58MP0000703_abnormal_thymus_morphology1.25023430
59MP0002148_abnormal_hypersensitivity_rea1.22540748
60MP0005058_abnormal_lysosome_morphology1.22241229
61MP0001845_abnormal_inflammatory_respons1.21931047
62MP0005330_cardiomyopathy1.20653858
63MP0010368_abnormal_lymphatic_system1.19475651
64MP0010155_abnormal_intestine_physiology1.19314675
65MP0003656_abnormal_erythrocyte_physiolo1.19214979
66MP0005220_abnormal_exocrine_pancreas1.18388748
67MP0004084_abnormal_cardiac_muscle1.17191999
68MP0004036_abnormal_muscle_relaxation1.13394373
69MP0000598_abnormal_liver_morphology1.11276446
70MP0000015_abnormal_ear_pigmentation1.10398979
71MP0002398_abnormal_bone_marrow1.08828323
72MP0000689_abnormal_spleen_morphology1.07816448
73MP0000716_abnormal_immune_system1.07664148
74MP0001764_abnormal_homeostasis1.06391958
75MP0003866_abnormal_defecation1.06130868
76MP0009278_abnormal_bone_marrow1.05152805
77MP0009763_increased_sensitivity_to1.04398221
78MP0001663_abnormal_digestive_system1.04007472
79MP0008004_abnormal_stomach_pH1.03035258
80MP0001851_eye_inflammation1.02960081
81MP0004019_abnormal_vitamin_homeostasis1.02346351
82MP0000858_altered_metastatic_potential1.01641289
83MP0003868_abnormal_feces_composition1.00820855
84MP0005166_decreased_susceptibility_to0.99780280
85MP0003075_altered_response_to0.99585187
86MP0002078_abnormal_glucose_homeostasis0.98840618
87MP0002254_reproductive_system_inflammat0.98829681
88MP0002405_respiratory_system_inflammati0.96839309
89MP0002429_abnormal_blood_cell0.95867769
90MP0005390_skeleton_phenotype0.93655502
91MP0003183_abnormal_peptide_metabolism0.93410330
92MP0008775_abnormal_heart_ventricle0.93391060
93MP0002277_abnormal_respiratory_mucosa0.93132532
94MP0009642_abnormal_blood_homeostasis0.92841975
95MP0004947_skin_inflammation0.92760532
96MP0002722_abnormal_immune_system0.91598157
97MP0010630_abnormal_cardiac_muscle0.91054953
98MP0003300_gastrointestinal_ulcer0.90526372
99* MP0000749_muscle_degeneration0.90502776
100MP0005075_abnormal_melanosome_morpholog0.88983315
101MP0001958_emphysema0.88371160
102MP0005451_abnormal_body_composition0.88211650
103MP0005397_hematopoietic_system_phenotyp0.87343549
104MP0001545_abnormal_hematopoietic_system0.87343549
105MP0000343_altered_response_to0.86834431
106MP0002971_abnormal_brown_adipose0.86438971
107MP0002928_abnormal_bile_duct0.85318273
108MP0005334_abnormal_fat_pad0.84370497
109MP0000604_amyloidosis0.83985045
110MP0005666_abnormal_adipose_tissue0.83950674
111MP0002693_abnormal_pancreas_physiology0.83290351
112MP0002933_joint_inflammation0.82946576
113MP0001986_abnormal_taste_sensitivity0.82563899
114MP0003828_pulmonary_edema0.82421643
115MP0003303_peritoneal_inflammation0.82186552
116MP0002132_abnormal_respiratory_system0.81670275
117MP0004883_abnormal_blood_vessel0.81491347
118MP0003690_abnormal_glial_cell0.80670825
119MP0006082_CNS_inflammation0.79499975
120MP0005636_abnormal_mineral_homeostasis0.76648590
121MP0009697_abnormal_copulation0.76646817
122MP0005164_abnormal_response_to0.75782809
123MP0001879_abnormal_lymphatic_vessel0.75600880
124MP0009333_abnormal_splenocyte_physiolog0.75057988
125MP0000249_abnormal_blood_vessel0.74966227
126MP0003186_abnormal_redox_activity0.74820222
127MP0004808_abnormal_hematopoietic_stem0.74522608
128MP0005535_abnormal_body_temperature0.73917363
129MP0000490_abnormal_crypts_of0.71503708
130MP0003279_aneurysm0.69842876
131MP0009765_abnormal_xenobiotic_induced0.68395152
132MP0003045_fibrosis0.67745617
133MP0003448_altered_tumor_morphology0.67621512
134MP0005375_adipose_tissue_phenotype0.67167294
135MP0003795_abnormal_bone_structure0.65582740
136MP0005381_digestive/alimentary_phenotyp0.64826956
137MP0002136_abnormal_kidney_physiology0.59584925
138MP0004185_abnormal_adipocyte_glucose0.56957347
139MP0008874_decreased_physiological_sensi0.54945037
140MP0009115_abnormal_fat_cell0.50634445
141MP0003453_abnormal_keratinocyte_physiol0.49835964

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.61225256
2Hypoglycemic coma (HP:0001325)4.50141623
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.46723986
4Stomatitis (HP:0010280)4.18334546
5Mediastinal lymphadenopathy (HP:0100721)3.95854347
6Orchitis (HP:0100796)3.95844700
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.91597931
8Meningitis (HP:0001287)3.90459428
9Obstructive lung disease (HP:0006536)3.89545879
10Chronic obstructive pulmonary disease (HP:0006510)3.89545879
11Abnormality of fatty-acid metabolism (HP:0004359)3.86056058
12Optic neuritis (HP:0100653)3.70443791
13Retrobulbar optic neuritis (HP:0100654)3.70443791
14Ketosis (HP:0001946)3.55397510
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51444067
16Xanthomatosis (HP:0000991)3.49591486
17Vasculitis (HP:0002633)3.48358322
18Recurrent cutaneous fungal infections (HP:0011370)3.45209233
19Chronic mucocutaneous candidiasis (HP:0002728)3.45209233
20Recurrent skin infections (HP:0001581)3.44610501
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.41543379
22Intrahepatic cholestasis (HP:0001406)3.39511466
23Ketoacidosis (HP:0001993)3.37291926
24Generalized aminoaciduria (HP:0002909)3.36840422
25Increased IgE level (HP:0003212)3.34925162
26Hyperammonemia (HP:0001987)3.29317514
27Abnormality of liposaccharide metabolism (HP:0010968)3.25112580
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.25112580
29Abnormality of glycolipid metabolism (HP:0010969)3.25112580
30Hyperglycinuria (HP:0003108)3.17547449
31Panhypogammaglobulinemia (HP:0003139)3.16786836
32Hyperlipoproteinemia (HP:0010980)3.15675159
33Prolonged partial thromboplastin time (HP:0003645)3.06612626
34Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06474366
35Dicarboxylic aciduria (HP:0003215)3.06474366
36Deep venous thrombosis (HP:0002625)3.06084347
37Recurrent viral infections (HP:0004429)3.05938705
38Cellulitis (HP:0100658)3.04375631
39Encephalitis (HP:0002383)3.03307018
40Pulmonary infiltrates (HP:0002113)3.02198087
41Myoglobinuria (HP:0002913)3.01485700
42Prolonged bleeding time (HP:0003010)2.94501304
43Gingivitis (HP:0000230)2.94229352
44Conjugated hyperbilirubinemia (HP:0002908)2.93351387
45Hemoptysis (HP:0002105)2.91724468
46Hypobetalipoproteinemia (HP:0003563)2.91234918
47Dysostosis multiplex (HP:0000943)2.90339365
48Late onset (HP:0003584)2.88983383
49Hypoglycemic seizures (HP:0002173)2.79184015
50Increased IgM level (HP:0003496)2.78373870
51Joint hemorrhage (HP:0005261)2.75398010
52Spontaneous hematomas (HP:0007420)2.75309348
53Chest pain (HP:0100749)2.73206388
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72198210
55Abnormality of polysaccharide metabolism (HP:0011012)2.72133072
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72133072
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72133072
58Vacuolated lymphocytes (HP:0001922)2.71376859
59Eczematoid dermatitis (HP:0000976)2.63384911
60Urticaria (HP:0001025)2.58123710
61Hyperbilirubinemia (HP:0002904)2.54027209
62Recurrent gram-negative bacterial infections (HP:0005420)2.53432620
63Complement deficiency (HP:0004431)2.52969233
64Gastrointestinal stroma tumor (HP:0100723)2.52797463
65Metabolic acidosis (HP:0001942)2.52734781
66Asymmetric septal hypertrophy (HP:0001670)2.52733577
67T lymphocytopenia (HP:0005403)2.52326265
68Elevated erythrocyte sedimentation rate (HP:0003565)2.51975961
69Osteomyelitis (HP:0002754)2.50042611
70Malnutrition (HP:0004395)2.49856843
71Abnormality of the common coagulation pathway (HP:0010990)2.49625703
72Keratoconjunctivitis sicca (HP:0001097)2.47806208
73Amyloidosis (HP:0011034)2.47792158
74Abnormality of T cell number (HP:0011839)2.46682688
75Granulocytopenia (HP:0001913)2.46421023
76Abnormality of glycine metabolism (HP:0010895)2.46329737
77Abnormality of serine family amino acid metabolism (HP:0010894)2.46329737
78Renal cortical cysts (HP:0000803)2.45209479
79Colitis (HP:0002583)2.44726720
80Lymphopenia (HP:0001888)2.44466423
81Systemic lupus erythematosus (HP:0002725)2.43490869
82Leukocytosis (HP:0001974)2.43478572
83Loss of speech (HP:0002371)2.43223293
84Abnormality of T cells (HP:0002843)2.42561571
85Epidermoid cyst (HP:0200040)2.41557857
86Restrictive lung disease (HP:0002091)2.40994573
87Urinary glycosaminoglycan excretion (HP:0003541)2.40466336
88Mucopolysacchariduria (HP:0008155)2.40466336
89Hypergammaglobulinemia (HP:0010702)2.39451559
90IgM deficiency (HP:0002850)2.38713537
91Abnormality of the fingertips (HP:0001211)2.35995086
92Severe visual impairment (HP:0001141)2.35903825
93Fat malabsorption (HP:0002630)2.33122853
94Hyperinsulinemic hypoglycemia (HP:0000825)2.32770097
95Episodic fever (HP:0001954)2.32748533
96Abnormality of the pleura (HP:0002103)2.32483351
97Increased cerebral lipofuscin (HP:0011813)2.31508296
98Nausea (HP:0002018)2.29946606
99Hypolipoproteinemia (HP:0010981)2.29792251
100Keratoconjunctivitis (HP:0001096)2.28662346
101Purpura (HP:0000979)2.28462830
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.25049821
103Hyperglycinemia (HP:0002154)2.23862044
104Emphysema (HP:0002097)2.23425870
105Hypercholesterolemia (HP:0003124)2.23194637
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23111739
107Hepatosplenomegaly (HP:0001433)2.23089519
108Recurrent bacterial skin infections (HP:0005406)2.22902880
109Recurrent abscess formation (HP:0002722)2.20816460
110Mitral stenosis (HP:0001718)2.18428588
111Pulmonary embolism (HP:0002204)2.16577920
112Acne (HP:0001061)2.16432467
113Chronic diarrhea (HP:0002028)2.15875637
114Hypoalphalipoproteinemia (HP:0003233)2.14978462
115Abnormality of the intrinsic pathway (HP:0010989)2.14208718
116Limb hypertonia (HP:0002509)2.13431974
117Increased muscle lipid content (HP:0009058)2.12689727
118Rhabdomyolysis (HP:0003201)2.11755950
119Abnormality of T cell physiology (HP:0011840)2.11584888
120Pancreatitis (HP:0001733)2.11165881
121Exercise-induced myalgia (HP:0003738)2.10292924
122Recurrent pneumonia (HP:0006532)2.10064118
123Hydroxyprolinuria (HP:0003080)2.09314858
124Abnormality of proline metabolism (HP:0010907)2.09314858
125Abnormality of sulfur amino acid metabolism (HP:0004339)2.08225849
126Petechiae (HP:0000967)2.08061430
127Ventricular tachycardia (HP:0004756)2.07859468
128Hepatic necrosis (HP:0002605)2.05819853
129Inflammation of the large intestine (HP:0002037)2.05667315
130Ragged-red muscle fibers (HP:0003200)2.05495069
131Recurrent bronchitis (HP:0002837)2.04663939
132Symptomatic seizures (HP:0011145)2.04210188
133Increased serum ferritin (HP:0003281)2.03298064
134Chronic otitis media (HP:0000389)2.03026121
135Skin nodule (HP:0200036)2.02334593
136Seborrheic dermatitis (HP:0001051)2.01940054
137Papilloma (HP:0012740)2.01533161
138Verrucae (HP:0200043)2.01533161
139Impaired platelet aggregation (HP:0003540)2.00532576
140Abnormal platelet function (HP:0011869)2.00532576
141Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00301541
142J-shaped sella turcica (HP:0002680)1.99464157
143Arthralgia (HP:0002829)1.99245257
144Nasal polyposis (HP:0100582)1.98404883
145Elevated hepatic transaminases (HP:0002910)1.97795545
146Gastrointestinal inflammation (HP:0004386)1.97747507
147Palpitations (HP:0001962)1.97433974
148Sepsis (HP:0100806)1.97164319
149Hypochromic anemia (HP:0001931)1.95402948
150Interstitial pulmonary disease (HP:0006530)1.95205906
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.95202540
152Myocardial infarction (HP:0001658)1.95128537
153Joint swelling (HP:0001386)1.94841784
154Gingival bleeding (HP:0000225)1.92784267
155Neoplasm of head and neck (HP:0012288)1.92468547
156Esophageal neoplasm (HP:0100751)1.92468547
157Abnormality of the nasal mucosa (HP:0000433)1.92009327
158Lipoatrophy (HP:0100578)1.91896876
159Recurrent lower respiratory tract infections (HP:0002783)1.91805076
160Polygenic inheritance (HP:0010982)1.90164861
161Growth hormone excess (HP:0000845)1.87114446
162Abnormality of pyrimidine metabolism (HP:0004353)1.85785907
163* Dilated cardiomyopathy (HP:0001644)1.85504021
164Proximal tubulopathy (HP:0000114)1.85123246
165Autoimmune thrombocytopenia (HP:0001973)1.85019824
166Abnormality of nucleobase metabolism (HP:0010932)1.83593065
167Pustule (HP:0200039)1.83252975
168Gastrointestinal infarctions (HP:0005244)1.82572288
169Abnormality of purine metabolism (HP:0004352)1.82496645
170Myositis (HP:0100614)1.82314334
171Epistaxis (HP:0000421)1.81918117
172Recurrent fungal infections (HP:0002841)1.80904654
173Agammaglobulinemia (HP:0004432)1.80227966
174Recurrent sinusitis (HP:0011108)1.79690398
175Abnormality of methionine metabolism (HP:0010901)1.79364266
176Abnormality of iron homeostasis (HP:0011031)1.79109659
177Abnormality of complement system (HP:0005339)1.78907319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.58283594
2MAP4K13.41018328
3ERN13.36926730
4RIPK43.25672352
5IRAK32.68779404
6MAPK152.52527611
7TRIB32.49643644
8FGFR42.45222723
9TBK12.37577494
10MAP3K102.36754843
11TNK22.33357757
12FES2.14253438
13TYK22.10883606
14MAP2K31.96340210
15IKBKE1.87940991
16KIT1.87938930
17ZAP701.87390644
18INSRR1.86867879
19MAP3K141.83260566
20PIK3CG1.82473914
21SIK11.82115655
22MYLK1.78533915
23FLT31.73888778
24BTK1.71616089
25PKN21.66104584
26IRAK41.63546131
27TGFBR21.57466317
28PRKD21.55425286
29JAK31.53716876
30TXK1.50386460
31MAPKAPK31.49375122
32TEC1.41896414
33BLK1.38809998
34JAK11.38382585
35TTN1.35584620
36KDR1.35406865
37MARK21.31652391
38IKBKB1.31636926
39TAOK31.26823147
40CDC42BPA1.26030778
41EPHA31.23872283
42ITK1.17466520
43CHUK1.16316005
44TIE11.15254443
45SYK1.15126405
46FGR1.09837558
47RPS6KA41.07335986
48TAOK21.07245372
49MARK31.04429212
50TAOK11.03868514
51OBSCN1.00833890
52PTK60.98194332
53CSF1R0.98079056
54MAP3K110.96832368
55MAP3K70.93949113
56MAP3K60.90687092
57PRKAA20.88000889
58GRK60.87635231
59RIPK10.86561943
60DYRK1B0.84715480
61NLK0.83047869
62STK160.80111774
63PDK10.79603271
64HIPK20.79395443
65CAMK1D0.78875734
66NEK90.77502853
67CSK0.77159090
68PRKCQ0.76963614
69LCK0.76078145
70IRAK10.76052248
71EPHB10.75800432
72PINK10.74700744
73MAPK70.74329869
74JAK20.74060871
75GRK70.73600041
76SIK30.71876952
77PRKG20.71748524
78NME20.71492426
79MAP2K60.70739228
80MAP3K130.69667466
81MAP3K30.68929928
82PDPK10.68360170
83STK380.67411004
84FYN0.66089498
85LYN0.65289687
86PHKG20.63203909
87PHKG10.63203909
88CAMKK10.62848380
89HCK0.62553093
90ZAK0.62330171
91MAPK110.61727349
92PIM10.60302124
93MUSK0.60246827
94CDK40.56370734
95MAPK120.55609934
96BMPR20.54947226
97RPS6KA60.54102619
98PRPF4B0.53146377
99FGFR30.53121390
100RPS6KA20.49656242
101CDK190.49451707
102DAPK20.48715812
103PRKD10.46541411
104PRKAA10.45118563
105CAMK40.44378505
106PTK2B0.44306244
107MAPK40.43577816
108MATK0.42544597
109MAP3K10.40991365
110STK100.40541879
111PRKCH0.40447707
112TGFBR10.39052156
113MAPK30.38597513
114SMG10.38589127
115LRRK20.38341123
116CDK90.38044170
117DYRK30.37981806
118NUAK10.37960852
119STK110.37124603
120RPS6KL10.36275764
121RPS6KC10.36275764
122TESK20.36118869
123GRK10.35800071
124LMTK20.35518258
125MAP3K120.34164753
126MAP2K20.33766679
127CAMK10.33467901
128PIM20.33053433
129RPS6KA50.32290897
130SIK20.31784875
131MAPKAPK20.31627309
132CAMK1G0.31519534
133BMX0.29252121

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.38349675
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.21290206
3Allograft rejection_Homo sapiens_hsa053302.92226493
4Graft-versus-host disease_Homo sapiens_hsa053322.88770847
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80295884
6Autoimmune thyroid disease_Homo sapiens_hsa053202.75501929
7Tryptophan metabolism_Homo sapiens_hsa003802.54562925
8Propanoate metabolism_Homo sapiens_hsa006402.39608529
9Peroxisome_Homo sapiens_hsa041462.22922508
10PPAR signaling pathway_Homo sapiens_hsa033202.21068331
11Type I diabetes mellitus_Homo sapiens_hsa049402.19000578
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18954858
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16825897
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15644832
15Fatty acid metabolism_Homo sapiens_hsa012122.14418822
16Caffeine metabolism_Homo sapiens_hsa002322.00937246
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98055273
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.97524555
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93837719
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93259739
21Antigen processing and presentation_Homo sapiens_hsa046121.92885001
22Staphylococcus aureus infection_Homo sapiens_hsa051501.92185364
23Complement and coagulation cascades_Homo sapiens_hsa046101.86659159
24Tuberculosis_Homo sapiens_hsa051521.82328819
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79542117
26Arginine biosynthesis_Homo sapiens_hsa002201.72974037
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71407203
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65010606
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63980617
30ABC transporters_Homo sapiens_hsa020101.63659950
31T cell receptor signaling pathway_Homo sapiens_hsa046601.61903347
32Starch and sucrose metabolism_Homo sapiens_hsa005001.59649392
33Selenocompound metabolism_Homo sapiens_hsa004501.55800099
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54860211
35TNF signaling pathway_Homo sapiens_hsa046681.50132569
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49556874
37Rheumatoid arthritis_Homo sapiens_hsa053231.46900175
38Malaria_Homo sapiens_hsa051441.46017080
39Fat digestion and absorption_Homo sapiens_hsa049751.44071454
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43079655
41Folate biosynthesis_Homo sapiens_hsa007901.42790540
42Butanoate metabolism_Homo sapiens_hsa006501.41723802
43Histidine metabolism_Homo sapiens_hsa003401.41705957
44Primary immunodeficiency_Homo sapiens_hsa053401.41551275
45beta-Alanine metabolism_Homo sapiens_hsa004101.41423181
46Carbon metabolism_Homo sapiens_hsa012001.40934245
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.33966401
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33167215
49Pyruvate metabolism_Homo sapiens_hsa006201.32242176
50Other glycan degradation_Homo sapiens_hsa005111.31265919
51Chemokine signaling pathway_Homo sapiens_hsa040621.31127514
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29013400
53Lysine degradation_Homo sapiens_hsa003101.26842502
54Galactose metabolism_Homo sapiens_hsa000521.25529232
55Sulfur metabolism_Homo sapiens_hsa009201.23646342
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23264188
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19903270
58Sulfur relay system_Homo sapiens_hsa041221.15155397
59Nitrogen metabolism_Homo sapiens_hsa009101.11846616
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09010561
61African trypanosomiasis_Homo sapiens_hsa051431.08003788
62Fatty acid elongation_Homo sapiens_hsa000621.02665597
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.02341235
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.01855238
65Bile secretion_Homo sapiens_hsa049761.01230477
66Insulin resistance_Homo sapiens_hsa049311.00221641
67Notch signaling pathway_Homo sapiens_hsa043300.98759651
68Phagosome_Homo sapiens_hsa041450.97868168
69Fructose and mannose metabolism_Homo sapiens_hsa000510.95535565
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95323516
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.94629664
72Platelet activation_Homo sapiens_hsa046110.93988727
73Hepatitis B_Homo sapiens_hsa051610.93244562
74B cell receptor signaling pathway_Homo sapiens_hsa046620.92366995
75Leishmaniasis_Homo sapiens_hsa051400.90821078
76Glycerolipid metabolism_Homo sapiens_hsa005610.89000259
77Salmonella infection_Homo sapiens_hsa051320.87909426
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.87034169
79Chemical carcinogenesis_Homo sapiens_hsa052040.86290316
80Shigellosis_Homo sapiens_hsa051310.85905993
81Phenylalanine metabolism_Homo sapiens_hsa003600.85682667
82Retinol metabolism_Homo sapiens_hsa008300.84869562
83VEGF signaling pathway_Homo sapiens_hsa043700.84681404
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83572292
85Measles_Homo sapiens_hsa051620.83541379
86Biosynthesis of amino acids_Homo sapiens_hsa012300.83356732
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83296481
88Hematopoietic cell lineage_Homo sapiens_hsa046400.79596668
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77704948
90Vitamin digestion and absorption_Homo sapiens_hsa049770.77380462
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76741648
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75527417
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73071811
94Tyrosine metabolism_Homo sapiens_hsa003500.72371113
95* Glycerophospholipid metabolism_Homo sapiens_hsa005640.72178270
96Osteoclast differentiation_Homo sapiens_hsa043800.71979664
97Legionellosis_Homo sapiens_hsa051340.71155587
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70260416
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70207168
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.69930301
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67064719
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.66121177
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65315671
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62248556
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61649960
106Pentose phosphate pathway_Homo sapiens_hsa000300.61532846
107Endocytosis_Homo sapiens_hsa041440.61461081
108Epstein-Barr virus infection_Homo sapiens_hsa051690.61223333
109Asthma_Homo sapiens_hsa053100.60739545
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.60505343
111Protein export_Homo sapiens_hsa030600.59185584
112Arginine and proline metabolism_Homo sapiens_hsa003300.59098790
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59045060
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.58371552
115HTLV-I infection_Homo sapiens_hsa051660.57966281
116Acute myeloid leukemia_Homo sapiens_hsa052210.57821029
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.56947866
118Non-small cell lung cancer_Homo sapiens_hsa052230.56588897
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.55062734
120Chronic myeloid leukemia_Homo sapiens_hsa052200.54525284
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52766328
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52127131
123Pancreatic cancer_Homo sapiens_hsa052120.51067570
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49715467
125* Choline metabolism in cancer_Homo sapiens_hsa052310.49146474
126Prolactin signaling pathway_Homo sapiens_hsa049170.48812800
127Inositol phosphate metabolism_Homo sapiens_hsa005620.48149194
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47255658
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46974895
130Amoebiasis_Homo sapiens_hsa051460.46548006
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46394982
132Influenza A_Homo sapiens_hsa051640.46171562
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.44666006
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43383483
135Herpes simplex infection_Homo sapiens_hsa051680.43322407
136Toxoplasmosis_Homo sapiens_hsa051450.43251020
137GnRH signaling pathway_Homo sapiens_hsa049120.42801461
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42065874
139MAPK signaling pathway_Homo sapiens_hsa040100.40336655
140* Metabolic pathways_Homo sapiens_hsa011000.40116426
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37957288
142Arachidonic acid metabolism_Homo sapiens_hsa005900.35921338
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35406374
144Insulin signaling pathway_Homo sapiens_hsa049100.35010174
145Viral carcinogenesis_Homo sapiens_hsa052030.34937678
146Apoptosis_Homo sapiens_hsa042100.34873677
147Lysosome_Homo sapiens_hsa041420.34608478
148Glucagon signaling pathway_Homo sapiens_hsa049220.34446433
149Regulation of autophagy_Homo sapiens_hsa041400.33601376
150Pertussis_Homo sapiens_hsa051330.32258730
151Hepatitis C_Homo sapiens_hsa051600.31338891
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.30103851
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29606796
154Viral myocarditis_Homo sapiens_hsa054160.29580515
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28869612
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27764109
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27743615
158FoxO signaling pathway_Homo sapiens_hsa040680.26581857
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25115618
160Linoleic acid metabolism_Homo sapiens_hsa005910.24288539
161Ether lipid metabolism_Homo sapiens_hsa005650.22660252

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