CHMP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.38338798
2central nervous system myelination (GO:0022010)5.38338798
3fatty acid elongation (GO:0030497)5.17940989
4amyloid precursor protein catabolic process (GO:0042987)4.16732371
5neutrophil activation involved in immune response (GO:0002283)4.02102825
6negative regulation of cell killing (GO:0031342)3.83594683
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83594683
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66250918
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66250918
10virion attachment to host cell (GO:0019062)3.63691701
11adhesion of symbiont to host cell (GO:0044650)3.63691701
12cholesterol biosynthetic process (GO:0006695)3.60871565
13response to peptidoglycan (GO:0032494)3.60852709
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59134260
15amyloid precursor protein metabolic process (GO:0042982)3.56319988
16creatine metabolic process (GO:0006600)3.47585388
17negative regulation of glycoprotein biosynthetic process (GO:0010561)3.44396972
18antigen processing and presentation of endogenous antigen (GO:0019883)3.37206738
19neutrophil mediated immunity (GO:0002446)3.32474235
20positive regulation of heat generation (GO:0031652)3.29726777
21regulation of germinal center formation (GO:0002634)3.28953005
22axon ensheathment (GO:0008366)3.24399758
23ensheathment of neurons (GO:0007272)3.24399758
24RNA destabilization (GO:0050779)3.21112889
25regulation of B cell receptor signaling pathway (GO:0050855)3.18728023
26myelin maintenance (GO:0043217)3.18260296
27myelination (GO:0042552)3.18161374
28signal peptide processing (GO:0006465)3.17250390
29sterol biosynthetic process (GO:0016126)3.17197270
30tolerance induction (GO:0002507)3.11442676
31membrane protein ectodomain proteolysis (GO:0006509)3.04606924
32positive regulation of interleukin-17 production (GO:0032740)3.02716230
33positive regulation of toll-like receptor signaling pathway (GO:0034123)2.99341516
34adhesion of symbiont to host (GO:0044406)2.97175258
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96437812
36leukocyte aggregation (GO:0070486)2.93518297
37modulation by symbiont of host immune response (GO:0052553)2.88744392
38positive regulation by symbiont of host defense response (GO:0052509)2.88744392
39modulation by symbiont of host defense response (GO:0052031)2.88744392
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88744392
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88744392
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.88744392
43regulation of fever generation (GO:0031620)2.88319768
44nucleotide transmembrane transport (GO:1901679)2.84794051
45long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.84303834
46regulation of mast cell activation (GO:0033003)2.83073001
47leukocyte migration involved in inflammatory response (GO:0002523)2.82180468
48regulation of gamma-delta T cell activation (GO:0046643)2.82048768
49membrane raft organization (GO:0031579)2.81902146
50negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.81616025
51positive regulation of interleukin-1 beta secretion (GO:0050718)2.81328188
52regulation of T cell mediated cytotoxicity (GO:0001914)2.79804886
53regulation of heat generation (GO:0031650)2.78475675
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77882433
55regulation of collateral sprouting (GO:0048670)2.75418611
56negative regulation of lymphocyte mediated immunity (GO:0002707)2.75369880
57dendritic cell migration (GO:0036336)2.75136426
58negative regulation of interleukin-1 beta production (GO:0032691)2.74967202
59positive regulation of gamma-delta T cell activation (GO:0046645)2.74909572
60positive regulation of actin filament depolymerization (GO:0030836)2.74485190
61positive regulation of prostaglandin secretion (GO:0032308)2.71285696
62neutrophil activation (GO:0042119)2.70521901
63positive regulation of interleukin-1 secretion (GO:0050716)2.69735757
64negative regulation of T cell mediated immunity (GO:0002710)2.68471720
65myeloid cell homeostasis (GO:0002262)2.66735573
66Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66708295
67macrophage activation (GO:0042116)2.65822291
68negative regulation of interleukin-12 production (GO:0032695)2.64850568
69cellular response to interleukin-15 (GO:0071350)2.64570511
70response to lipoprotein particle (GO:0055094)2.62615945
71granulocyte activation (GO:0036230)2.61717225
72long-chain fatty acid biosynthetic process (GO:0042759)2.61283498
73negative regulation of glycoprotein metabolic process (GO:1903019)2.61045473
74positive regulation of pseudopodium assembly (GO:0031274)2.60827166
75respiratory burst (GO:0045730)2.59320076
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59261376
77positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58391921
78intracellular pH reduction (GO:0051452)2.57577919
79positive regulation of mast cell activation (GO:0033005)2.56881173
80positive regulation of osteoclast differentiation (GO:0045672)2.56777189
81myeloid leukocyte mediated immunity (GO:0002444)2.56436923
82negative regulation of interleukin-1 production (GO:0032692)2.55671787
83regulation of interleukin-1 beta secretion (GO:0050706)2.55635570
84long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.54736058
85regulation of gamma-delta T cell differentiation (GO:0045586)2.54707258
86dendritic cell chemotaxis (GO:0002407)2.53611763
87fatty-acyl-CoA biosynthetic process (GO:0046949)2.53261314
88regulation of mast cell degranulation (GO:0043304)2.51944679
89positive regulation of cellular amine metabolic process (GO:0033240)2.51327660
90glycosylceramide metabolic process (GO:0006677)2.50858158
91germinal center formation (GO:0002467)2.50559751
92regulation of cellular extravasation (GO:0002691)2.50295595
93cellular extravasation (GO:0045123)2.47973022
94regulation of mast cell activation involved in immune response (GO:0033006)2.47964961
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.47937594
96negative regulation of lipid storage (GO:0010888)2.47352066
97regulation of metalloenzyme activity (GO:0048552)2.46206166
98L-phenylalanine catabolic process (GO:0006559)2.45812662
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45812662
100membrane protein intracellular domain proteolysis (GO:0031293)2.45172767
101regulation of lipoprotein metabolic process (GO:0050746)2.45124664
102regulation of T cell migration (GO:2000404)2.44290548
103actin nucleation (GO:0045010)2.44224887
104positive regulation of B cell differentiation (GO:0045579)2.44111409
105B cell mediated immunity (GO:0019724)2.44092234
106negative regulation of interleukin-6 production (GO:0032715)2.43854037
107T-helper 1 type immune response (GO:0042088)2.43651452
108very long-chain fatty acid metabolic process (GO:0000038)2.43534701
109regulation of interleukin-6 biosynthetic process (GO:0045408)2.43362935
110T-helper cell differentiation (GO:0042093)2.43155097
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.43155097
112membrane protein proteolysis (GO:0033619)2.43068457
113regulation of interferon-beta biosynthetic process (GO:0045357)2.41854737
114microglial cell activation (GO:0001774)2.41465996
115regulation of interleukin-17 production (GO:0032660)2.40781298
116regulation of alpha-beta T cell proliferation (GO:0046640)2.40033178
117negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.39705122
118interferon-gamma-mediated signaling pathway (GO:0060333)2.39502473
119macrophage activation involved in immune response (GO:0002281)2.39110526
120regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.38809400
121isoprenoid biosynthetic process (GO:0008299)2.38768460
122fatty-acyl-CoA metabolic process (GO:0035337)2.38194550
123protein K11-linked deubiquitination (GO:0035871)2.37449535
124defense response to protozoan (GO:0042832)2.37355702
125positive regulation of interleukin-2 production (GO:0032743)2.37223573
126negative regulation of leukocyte mediated immunity (GO:0002704)2.36666285
127DNA deamination (GO:0045006)2.36075552
128negative regulation of innate immune response (GO:0045824)2.35790765
129detection of bacterium (GO:0016045)2.35733899
130regulation of regulatory T cell differentiation (GO:0045589)2.34076010
131nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.33180578
132positive regulation of mast cell activation involved in immune response (GO:0033008)2.32910878
133positive regulation of mast cell degranulation (GO:0043306)2.32910878
134myeloid leukocyte activation (GO:0002274)2.32853805
135response to protozoan (GO:0001562)2.32475881
136regulation of interleukin-8 secretion (GO:2000482)2.31664497
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.31216017
138platelet dense granule organization (GO:0060155)2.30271804
139regulation of memory T cell differentiation (GO:0043380)2.30238855
140mast cell activation (GO:0045576)2.28971093
141hepatocyte apoptotic process (GO:0097284)2.28700616
142response to interleukin-15 (GO:0070672)2.28553067
143phagosome maturation (GO:0090382)2.28447376
144immunoglobulin mediated immune response (GO:0016064)2.27924704
145positive regulation of T cell migration (GO:2000406)2.27567061
146regulation of T cell receptor signaling pathway (GO:0050856)2.26842935
147neutrophil chemotaxis (GO:0030593)2.25801132
148myeloid cell activation involved in immune response (GO:0002275)2.25412697
149positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.25394096
150positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.24401601
151negative regulation of neurotransmitter secretion (GO:0046929)2.24007982
152vesicle fusion (GO:0006906)2.23759979
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.22035453
154regulation of lymphocyte migration (GO:2000401)2.20419568
155pH reduction (GO:0045851)2.19760349
156autophagic vacuole fusion (GO:0000046)2.19313329
157positive regulation of triglyceride lipase activity (GO:0061365)2.19008512
158positive regulation of lipoprotein lipase activity (GO:0051006)2.19008512
159leukocyte degranulation (GO:0043299)2.18907509
160negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.18491544
161regulation of pseudopodium assembly (GO:0031272)2.18330228
162positive regulation of interferon-alpha production (GO:0032727)2.17778791
163positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.16349476
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.15912589
165GPI anchor biosynthetic process (GO:0006506)2.14704091
166regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.14535394
167positive regulation of NF-kappaB import into nucleus (GO:0042346)2.13944914
168regulation of interferon-alpha production (GO:0032647)2.13638326
169regulation of superoxide anion generation (GO:0032928)2.13220771
170sphingosine metabolic process (GO:0006670)2.13072069
171detection of other organism (GO:0098543)2.10982461
172L-phenylalanine metabolic process (GO:0006558)2.10007541
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.10007541
174response to muramyl dipeptide (GO:0032495)2.09797058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34249787
2* IRF8_22096565_ChIP-ChIP_GC-B_Human4.30609850
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.64740824
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.31185727
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28049911
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26314009
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20418765
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.70077965
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69209631
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.68610016
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64752269
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.62738719
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57789978
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.47674543
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43984933
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35251884
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20979997
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17274849
19SCL_19346495_ChIP-Seq_HPC-7_Human2.15036874
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14628777
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07755429
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07263622
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01104736
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99500792
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97594658
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96003832
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91675579
28IGF1R_20145208_ChIP-Seq_DFB_Human1.89531753
29RUNX_20019798_ChIP-Seq_JUKART_Human1.87067911
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.82202082
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.76894660
32* SPI1_23547873_ChIP-Seq_NB4_Human1.72828845
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67996367
34MYB_26560356_Chip-Seq_TH2_Human1.67932041
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67003459
36SOX2_20726797_ChIP-Seq_SW620_Human1.65884528
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64247784
38ZNF274_21170338_ChIP-Seq_K562_Hela1.62275264
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57165045
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.56306349
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55264535
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54508679
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53058434
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50940644
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.50380707
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49748145
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49303733
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49034850
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43205221
50GATA1_22025678_ChIP-Seq_K562_Human1.42355353
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40921136
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40549059
53VDR_24763502_ChIP-Seq_THP-1_Human1.40513764
54GATA3_27048872_Chip-Seq_THYMUS_Human1.36991954
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.36416884
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.36046083
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35911647
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35345967
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.34990148
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33246473
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32819333
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.32197348
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29382614
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29168597
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26833494
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26745022
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26745022
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25772191
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.24602909
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24287145
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23325829
72PU_27001747_Chip-Seq_BMDM_Mouse1.22911231
73ER_23166858_ChIP-Seq_MCF-7_Human1.22254472
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21584880
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18561356
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18029703
77* GATA4_25053715_ChIP-Seq_YYC3_Human1.16761720
78CLOCK_20551151_ChIP-Seq_293T_Human1.16743051
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16670592
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16540675
81MAF_26560356_Chip-Seq_TH1_Human1.16108793
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15226687
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15226687
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13835083
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.13536643
86* VDR_23849224_ChIP-Seq_CD4+_Human1.13003624
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11664486
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10935077
89VDR_24787735_ChIP-Seq_THP-1_Human1.09755842
90MYB_26560356_Chip-Seq_TH1_Human1.09252947
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09237385
92VDR_21846776_ChIP-Seq_THP-1_Human1.08406006
93GATA3_26560356_Chip-Seq_TH2_Human1.08146990
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05995322
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05968203
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04170199
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03763663
98* SPI1_23127762_ChIP-Seq_K562_Human1.02668752
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01384799
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01105851
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01033194
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.00682897
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00073754
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99800026
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99008703
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98890131
107* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98144075
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96214034
109* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95172758
110ELK1_19687146_ChIP-ChIP_HELA_Human0.94866496
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93872663
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93302732
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92625160
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92486762
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90794156
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90524921
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89814236
118NANOG_19829295_ChIP-Seq_ESCs_Human0.89774934
119SOX2_19829295_ChIP-Seq_ESCs_Human0.89774934
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89553631
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89207819
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89142569
123SMRT_27268052_Chip-Seq_Bcells_Human0.88277690
124* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87843933
125* AR_20517297_ChIP-Seq_VCAP_Human0.87796220
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.87189760
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87065967
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86244992
129GATA1_19941826_ChIP-Seq_K562_Human0.86231068
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86152547
131GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85766599
132UTX_26944678_Chip-Seq_JUKART_Human0.85751658
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85607452
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85478145
135* CDX2_22108803_ChIP-Seq_LS180_Human0.83074246
136P300_19829295_ChIP-Seq_ESCs_Human0.82625117
137TAF15_26573619_Chip-Seq_HEK293_Human0.82492734
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.82132824
139GATA3_26560356_Chip-Seq_TH1_Human0.79165411
140CBP_20019798_ChIP-Seq_JUKART_Human0.78472163
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78472163
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.77294187
143TFEB_21752829_ChIP-Seq_HELA_Human0.76621604
144VDR_22108803_ChIP-Seq_LS180_Human0.76562739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination2.96824339
2MP0009785_altered_susceptibility_to2.76797070
3MP0001835_abnormal_antigen_presentation2.75317672
4MP0003724_increased_susceptibility_to2.75182391
5MP0000685_abnormal_immune_system2.47682172
6MP0005671_abnormal_response_to2.47227738
7MP0006082_CNS_inflammation2.44155957
8MP0005000_abnormal_immune_tolerance2.31182114
9MP0003436_decreased_susceptibility_to2.31051900
10MP0002148_abnormal_hypersensitivity_rea2.30797200
11MP0005058_abnormal_lysosome_morphology2.22568148
12MP0005387_immune_system_phenotype2.19262816
13MP0001790_abnormal_immune_system2.19262816
14MP0005025_abnormal_response_to2.16278109
15MP0002419_abnormal_innate_immunity2.14192638
16MP0003806_abnormal_nucleotide_metabolis2.06309725
17MP0000465_gastrointestinal_hemorrhage2.04435979
18MP0004381_abnormal_hair_follicle2.02774717
19MP0002166_altered_tumor_susceptibility2.00952331
20MP0002009_preneoplasia1.98895244
21MP0009840_abnormal_foam_cell1.97742219
22MP0002723_abnormal_immune_serum1.91425920
23MP0003690_abnormal_glial_cell1.91144224
24MP0003950_abnormal_plasma_membrane1.87710440
25MP0003195_calcinosis1.86937963
26MP0006054_spinal_hemorrhage1.85776859
27MP0002452_abnormal_antigen_presenting1.83377743
28MP0003828_pulmonary_edema1.81706449
29MP0004947_skin_inflammation1.77013077
30MP0001800_abnormal_humoral_immune1.73817209
31MP0002006_tumorigenesis1.73322394
32MP0001819_abnormal_immune_cell1.69351185
33MP0002420_abnormal_adaptive_immunity1.69283212
34MP0003183_abnormal_peptide_metabolism1.69089194
35MP0002933_joint_inflammation1.68373123
36MP0000383_abnormal_hair_follicle1.61294847
37MP0003300_gastrointestinal_ulcer1.61036233
38MP0010155_abnormal_intestine_physiology1.55471346
39MP0010678_abnormal_skin_adnexa1.54734088
40MP0001533_abnormal_skeleton_physiology1.53994197
41MP0005451_abnormal_body_composition1.50695881
42MP0003191_abnormal_cellular_cholesterol1.50415761
43MP0005464_abnormal_platelet_physiology1.49247950
44MP0003186_abnormal_redox_activity1.48392736
45MP0008260_abnormal_autophagy1.48132059
46MP0003656_abnormal_erythrocyte_physiolo1.47757426
47MP0003787_abnormal_imprinting1.47067542
48MP0002653_abnormal_ependyma_morphology1.44378561
49MP0000604_amyloidosis1.43638241
50MP0009333_abnormal_splenocyte_physiolog1.43202161
51MP0001501_abnormal_sleep_pattern1.39774514
52MP0001845_abnormal_inflammatory_respons1.38340996
53MP0008469_abnormal_protein_level1.37090711
54MP0004147_increased_porphyrin_level1.34827521
55MP0000716_abnormal_immune_system1.34249847
56MP0002405_respiratory_system_inflammati1.31154399
57MP0002254_reproductive_system_inflammat1.29806960
58MP0003453_abnormal_keratinocyte_physiol1.29435599
59MP0005360_urolithiasis1.29190207
60MP0002139_abnormal_hepatobiliary_system1.28993599
61MP0003303_peritoneal_inflammation1.28383225
62MP0008877_abnormal_DNA_methylation1.26515860
63MP0004484_altered_response_of1.24410904
64MP0009764_decreased_sensitivity_to1.23766404
65MP0005408_hypopigmentation1.19642515
66MP0001851_eye_inflammation1.19272466
67MP0008875_abnormal_xenobiotic_pharmacok1.19096914
68MP0000372_irregular_coat_pigmentation1.18928242
69MP0003011_delayed_dark_adaptation1.18555349
70MP0005167_abnormal_blood-brain_barrier1.18319313
71MP0003866_abnormal_defecation1.17075653
72MP0003329_amyloid_beta_deposits1.15168235
73MP0003763_abnormal_thymus_physiology1.14516408
74MP0002398_abnormal_bone_marrow1.14314041
75MP0002332_abnormal_exercise_endurance1.07976875
76MP0003448_altered_tumor_morphology1.06377178
77MP0005085_abnormal_gallbladder_physiolo1.04955222
78MP0000343_altered_response_to1.04259244
79MP0001666_abnormal_nutrient_absorption1.04188004
80MP0002429_abnormal_blood_cell1.04182041
81MP0002998_abnormal_bone_remodeling1.02730413
82MP0009643_abnormal_urine_homeostasis1.02417154
83MP0009278_abnormal_bone_marrow1.02000697
84MP0005310_abnormal_salivary_gland0.99934734
85MP0000689_abnormal_spleen_morphology0.98645094
86MP0001853_heart_inflammation0.98059290
87MP0004510_myositis0.97824523
88MP0002098_abnormal_vibrissa_morphology0.97806506
89MP0002837_dystrophic_cardiac_calcinosis0.97636186
90MP0005166_decreased_susceptibility_to0.96859575
91MP0005084_abnormal_gallbladder_morpholo0.96746632
92MP0002876_abnormal_thyroid_physiology0.94204228
93MP0002796_impaired_skin_barrier0.94013694
94MP0003252_abnormal_bile_duct0.93384101
95MP0000377_abnormal_hair_follicle0.92736682
96MP0008004_abnormal_stomach_pH0.92365276
97MP0002722_abnormal_immune_system0.91202845
98MP0001216_abnormal_epidermal_layer0.90399190
99MP0003045_fibrosis0.90100103
100MP0005164_abnormal_response_to0.89584322
101MP0001986_abnormal_taste_sensitivity0.89500592
102MP0005584_abnormal_enzyme/coenzyme_acti0.88629247
103MP0002877_abnormal_melanocyte_morpholog0.87758202
104MP0003075_altered_response_to0.87511618
105MP0005365_abnormal_bile_salt0.86465560
106MP0001764_abnormal_homeostasis0.86449347
107MP0003172_abnormal_lysosome_physiology0.86264026
108MP0000858_altered_metastatic_potential0.84855137
109MP0001545_abnormal_hematopoietic_system0.84631284
110MP0005397_hematopoietic_system_phenotyp0.84631284
111MP0001243_abnormal_dermal_layer0.83194823
112MP0000647_abnormal_sebaceous_gland0.82038660
113MP0002693_abnormal_pancreas_physiology0.81241198
114MP0003646_muscle_fatigue0.80906141
115MP0001873_stomach_inflammation0.79986485
116MP0005075_abnormal_melanosome_morpholog0.78198573
117MP0006072_abnormal_retinal_apoptosis0.77920245
118MP0009765_abnormal_xenobiotic_induced0.77751914
119MP0009763_increased_sensitivity_to0.76917879
120MP0001881_abnormal_mammary_gland0.76899244
121MP0002136_abnormal_kidney_physiology0.76340449
122MP0004043_abnormal_pH_regulation0.76184077
123MP0005535_abnormal_body_temperature0.75796624
124MP0002132_abnormal_respiratory_system0.75743489
125MP0002138_abnormal_hepatobiliary_system0.75154048
126MP0004883_abnormal_blood_vessel0.75096775
127MP0002277_abnormal_respiratory_mucosa0.74716720
128MP0001542_abnormal_bone_strength0.74522364
129MP0005390_skeleton_phenotype0.73718732
130MP0004782_abnormal_surfactant_physiolog0.73041671
131MP0008438_abnormal_cutaneous_collagen0.71738183
132MP0000609_abnormal_liver_physiology0.71588719
133MP0002928_abnormal_bile_duct0.70603745
134MP0005253_abnormal_eye_physiology0.69509388

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.10133800
2Neurofibrillary tangles (HP:0002185)3.84931850
3Elevated erythrocyte sedimentation rate (HP:0003565)3.77628216
4Abnormality of macrophages (HP:0004311)3.68712738
5Vacuolated lymphocytes (HP:0001922)3.50165219
6Chronic otitis media (HP:0000389)3.46778219
7Recurrent bacterial skin infections (HP:0005406)3.42588497
8Eczematoid dermatitis (HP:0000976)3.39991991
9Recurrent abscess formation (HP:0002722)3.35456741
10Hepatosplenomegaly (HP:0001433)3.35303146
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21547869
12Congenital ichthyosiform erythroderma (HP:0007431)3.03334279
13Stomach cancer (HP:0012126)3.02849249
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91823149
15Mediastinal lymphadenopathy (HP:0100721)2.81971443
16Abnormality of liposaccharide metabolism (HP:0010968)2.79689672
17Abnormality of glycosphingolipid metabolism (HP:0004343)2.79689672
18Abnormality of glycolipid metabolism (HP:0010969)2.79689672
19Myositis (HP:0100614)2.77123198
20Dysostosis multiplex (HP:0000943)2.73087766
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72952282
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.69303201
23Recurrent skin infections (HP:0001581)2.66366909
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66359652
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.66359652
26Spastic paraparesis (HP:0002313)2.65524047
27Orchitis (HP:0100796)2.64402207
28Hematochezia (HP:0002573)2.63599801
29Axonal loss (HP:0003447)2.62304344
30Purpura (HP:0000979)2.55387420
31T lymphocytopenia (HP:0005403)2.53542157
32Retrobulbar optic neuritis (HP:0100654)2.51947192
33Optic neuritis (HP:0100653)2.51947192
34Pulmonary infiltrates (HP:0002113)2.51474683
35Petechiae (HP:0000967)2.51373186
36Abnormality of T cell number (HP:0011839)2.46538913
37Increased cerebral lipofuscin (HP:0011813)2.45280984
38Keratoconjunctivitis (HP:0001096)2.45032765
39Alveolar cell carcinoma (HP:0006519)2.42282505
40Congenital sensorineural hearing impairment (HP:0008527)2.41769138
41Prolonged neonatal jaundice (HP:0006579)2.40746166
42Recurrent viral infections (HP:0004429)2.35353995
43Keratoconjunctivitis sicca (HP:0001097)2.33699048
44Vasculitis (HP:0002633)2.33681616
45Intrahepatic cholestasis (HP:0001406)2.30940738
46Interstitial pulmonary disease (HP:0006530)2.29820999
47Gastrointestinal infarctions (HP:0005244)2.29537259
48Recurrent gram-negative bacterial infections (HP:0005420)2.28992037
49Gingival bleeding (HP:0000225)2.28537195
50Hemoptysis (HP:0002105)2.26739760
51Peripheral hypomyelination (HP:0007182)2.26611378
52Premature loss of primary teeth (HP:0006323)2.26169116
53Severe combined immunodeficiency (HP:0004430)2.25808345
54Segmental peripheral demyelination/remyelination (HP:0003481)2.24303344
55Abnormal hemoglobin (HP:0011902)2.24049994
56Hemorrhage of the eye (HP:0011885)2.23577515
57Neoplasm of the tracheobronchial system (HP:0100552)2.23216827
58Osteolytic defects of the hand bones (HP:0009699)2.22906865
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.22906865
60Cerebral hemorrhage (HP:0001342)2.21922828
61Abnormality of the prostate (HP:0008775)2.19498010
62Stomatitis (HP:0010280)2.19207476
63Chest pain (HP:0100749)2.18611554
64Recurrent fungal infections (HP:0002841)2.17675418
65Abolished electroretinogram (ERG) (HP:0000550)2.16938827
66IgG deficiency (HP:0004315)2.13962479
67Cerebral inclusion bodies (HP:0100314)2.13838952
68Loss of speech (HP:0002371)2.10944990
69Erythroderma (HP:0001019)2.10929086
70Thyroiditis (HP:0100646)2.09147226
71Neonatal respiratory distress (HP:0002643)2.08701449
723-Methylglutaconic aciduria (HP:0003535)2.07496094
73Urticaria (HP:0001025)2.07036681
74Facial diplegia (HP:0001349)2.06896207
75Abnormality of the lumbar spine (HP:0100712)2.06474679
76Increased density of long bones (HP:0006392)2.04788149
77Mucopolysacchariduria (HP:0008155)2.04659868
78Urinary glycosaminoglycan excretion (HP:0003541)2.04659868
79Pustule (HP:0200039)2.03914451
80Gastrointestinal stroma tumor (HP:0100723)2.02620872
81Anorexia (HP:0002039)2.02496969
82Sensory axonal neuropathy (HP:0003390)2.01640519
83Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01217910
84Thick nail (HP:0001805)2.00978448
85IgM deficiency (HP:0002850)1.99270009
86Paraparesis (HP:0002385)1.98848468
87Abnormality of iron homeostasis (HP:0011031)1.98799458
88Abnormality of dental color (HP:0011073)1.96180973
89Agitation (HP:0000713)1.95976141
90Encephalitis (HP:0002383)1.93779159
91Leukocytosis (HP:0001974)1.93494156
92Anhidrosis (HP:0000970)1.93418431
93Abnormality of transition element cation homeostasis (HP:0011030)1.93340166
94Protuberant abdomen (HP:0001538)1.93271816
95Keratitis (HP:0000491)1.92571456
96Chronic mucocutaneous candidiasis (HP:0002728)1.91686422
97Recurrent cutaneous fungal infections (HP:0011370)1.91686422
98Type II lissencephaly (HP:0007260)1.90839615
99Increased IgM level (HP:0003496)1.90103976
100Patchy hypopigmentation of hair (HP:0011365)1.89937102
101Combined immunodeficiency (HP:0005387)1.89282718
102Abnormality of eosinophils (HP:0001879)1.88559378
103Stridor (HP:0010307)1.87746158
104Steatorrhea (HP:0002570)1.87531426
105Increased IgE level (HP:0003212)1.87179162
106Arterial thrombosis (HP:0004420)1.86936383
107Recurrent bronchitis (HP:0002837)1.86812536
108Increased CSF protein (HP:0002922)1.86755886
109Meningitis (HP:0001287)1.86706461
110Attenuation of retinal blood vessels (HP:0007843)1.86640615
111Increased serum ferritin (HP:0003281)1.85079980
112Recurrent pneumonia (HP:0006532)1.84562377
113Granulocytopenia (HP:0001913)1.84560706
114Joint swelling (HP:0001386)1.83825443
115Fat malabsorption (HP:0002630)1.83734262
116Polyneuropathy (HP:0001271)1.83592194
117Progressive neurologic deterioration (HP:0002344)1.83036527
118White forelock (HP:0002211)1.82866398
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82402808
120Obstructive lung disease (HP:0006536)1.81887071
121Chronic obstructive pulmonary disease (HP:0006510)1.81887071
122Slow saccadic eye movements (HP:0000514)1.81259592
123Peritonitis (HP:0002586)1.80903413
124Hypothermia (HP:0002045)1.80570292
125Onion bulb formation (HP:0003383)1.79506268
126Mutism (HP:0002300)1.79168180
127Spontaneous hematomas (HP:0007420)1.78812683
128Ketoacidosis (HP:0001993)1.78609224
129Ileus (HP:0002595)1.78427785
130Autoamputation (HP:0001218)1.78294841
131Chronic diarrhea (HP:0002028)1.77997503
132Premature skin wrinkling (HP:0100678)1.77979087
133Hypergammaglobulinemia (HP:0010702)1.77636083
134Abnormality of T cells (HP:0002843)1.77124590
135Xanthomatosis (HP:0000991)1.77096473
136Amyloidosis (HP:0011034)1.76729376
137Prolonged bleeding time (HP:0003010)1.76280970
138Abnormality of the pleura (HP:0002103)1.76097452
139Progressive inability to walk (HP:0002505)1.75744907
140Type 2 muscle fiber atrophy (HP:0003554)1.75682302
141Systemic lupus erythematosus (HP:0002725)1.74951633
142Eosinophilia (HP:0001880)1.74770695
143Gangrene (HP:0100758)1.74425333
144Congenital stationary night blindness (HP:0007642)1.73977468
145Pancreatitis (HP:0001733)1.73520523
146Vertigo (HP:0002321)1.72891018
147Prostate neoplasm (HP:0100787)1.72524224
148Cellulitis (HP:0100658)1.72295210
149Abnormality of polysaccharide metabolism (HP:0011012)1.70305574
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70305574
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70305574
152Renal Fanconi syndrome (HP:0001994)1.68890435
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65154451
154Episodic fever (HP:0001954)1.65039339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.22624302
2MST43.78829030
3EPHB13.35501727
4PBK3.28750930
5OXSR12.56278812
6FRK2.50629319
7MAP4K12.43798390
8BMPR22.26038362
9MAP3K142.17857988
10TESK21.97421591
11MET1.96451080
12TXK1.91087382
13LIMK11.86307954
14TBK11.84530823
15ERBB31.79503781
16TRIM281.78464429
17ADRBK21.76419836
18EPHA31.71887704
19IRAK41.64712740
20PINK11.62886477
21ITK1.62530171
22JAK31.56673530
23MAPKAPK51.56544045
24WNK41.56419515
25BCR1.55416148
26MAP4K21.52736583
27FES1.50971347
28BTK1.50871055
29IKBKE1.48484396
30GRK71.47638322
31KIT1.45762232
32NME21.45270362
33ERN11.43139118
34TNIK1.42825095
35TYK21.38419137
36PIM21.35988098
37FGFR41.35451037
38IKBKB1.34508657
39MAP3K121.33983199
40LRRK21.30573394
41STK101.30547849
42BLK1.29244142
43ZAP701.28940678
44CSK1.28380988
45CDK191.27997054
46CSF1R1.25949644
47GRK11.23661942
48PKN11.17236027
49TEC1.16942953
50BCKDK1.15811423
51PDK21.13247358
52FGFR21.13082114
53MUSK1.11745739
54MAP3K31.09803011
55TRPM71.07826892
56MAP3K41.06542285
57CAMKK21.06340072
58PRKCQ1.04914634
59MAP3K131.01363783
60EPHA21.01230897
61CLK11.01162901
62MAPK151.00457204
63BRSK21.00400884
64FER1.00159894
65LCK0.99676069
66DYRK30.99170950
67CSNK1G30.98658176
68STK160.97021710
69NLK0.93572024
70CSNK1A1L0.93116510
71SYK0.89964066
72DAPK20.89234928
73DYRK20.86812350
74STK38L0.86255046
75TAOK10.83591184
76MAP3K50.83574465
77ACVR1B0.83355145
78MAP2K70.82942751
79MAPK70.82736984
80EIF2AK30.82727503
81TAOK30.82072482
82TNK20.81338282
83MAP2K30.81260978
84IRAK10.79250195
85IRAK30.77807892
86MST1R0.77762714
87RPS6KA50.76680862
88ROCK20.76539757
89ADRBK10.76380027
90BMPR1B0.76342708
91FGR0.75890086
92PDGFRB0.72573685
93TGFBR20.71490596
94KDR0.70642817
95STK240.70281154
96WNK30.67849805
97ABL20.67645061
98LYN0.66312456
99GRK60.65174722
100HCK0.64944403
101WNK10.64725799
102ABL10.62902065
103CSNK1G10.61210457
104DYRK1B0.61110873
105PIK3CG0.60731068
106PIM10.58201924
107MAP3K60.58157884
108TESK10.56991154
109MAP3K20.56801636
110JAK10.55861255
111JAK20.55771788
112FGFR30.53239511
113YES10.52645463
114NEK90.52342372
115PAK30.52123777
116MAPKAPK20.51871215
117MAP2K20.50980033
118HIPK20.50833814
119NUAK10.50723123
120PDPK10.50232614
121MARK30.49991632
122MAP2K60.49808334
123IRAK20.48890779
124CHUK0.47687448
125ZAK0.44819515
126GRK50.44307035
127STK40.43927792
128CAMK2D0.43455668
129MOS0.42948932
130RPS6KA40.41371180
131PTK2B0.40842241
132PRKCE0.40717136
133CAMK2B0.39727496
134SIK30.39253363
135MAP3K110.38996063
136OBSCN0.38421097
137PRKD10.38215278
138MAP2K10.37855663
139IGF1R0.37563200
140FLT30.37216281
141CDK60.36547766
142MATK0.34994621
143PRKCD0.34734277
144RIPK40.34690372

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.58623192
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.13648314
3Fatty acid elongation_Homo sapiens_hsa000622.76983575
4Type I diabetes mellitus_Homo sapiens_hsa049402.71299989
5Protein export_Homo sapiens_hsa030602.28002523
6Sulfur metabolism_Homo sapiens_hsa009202.04271222
7Ether lipid metabolism_Homo sapiens_hsa005651.96698525
8Other glycan degradation_Homo sapiens_hsa005111.76119697
9Histidine metabolism_Homo sapiens_hsa003401.75447751
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.73723500
11Collecting duct acid secretion_Homo sapiens_hsa049661.72970307
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72280060
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71560406
14Malaria_Homo sapiens_hsa051441.71182904
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70093995
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69916500
17Primary immunodeficiency_Homo sapiens_hsa053401.59747696
18Leishmaniasis_Homo sapiens_hsa051401.58129267
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55811287
20Sphingolipid metabolism_Homo sapiens_hsa006001.55057660
21Lysosome_Homo sapiens_hsa041421.54013168
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52347418
23Folate biosynthesis_Homo sapiens_hsa007901.50808590
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49927383
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47097445
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44833692
27Staphylococcus aureus infection_Homo sapiens_hsa051501.42565869
28Viral myocarditis_Homo sapiens_hsa054161.41348944
29Graft-versus-host disease_Homo sapiens_hsa053321.38315788
30Phototransduction_Homo sapiens_hsa047441.36700041
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36559635
32Circadian rhythm_Homo sapiens_hsa047101.30761873
33Rheumatoid arthritis_Homo sapiens_hsa053231.29397019
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.28771063
35Hematopoietic cell lineage_Homo sapiens_hsa046401.28700740
36Shigellosis_Homo sapiens_hsa051311.28219301
37Pertussis_Homo sapiens_hsa051331.26837555
38Linoleic acid metabolism_Homo sapiens_hsa005911.24542412
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22003889
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17464847
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.16785157
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14818006
43Peroxisome_Homo sapiens_hsa041461.13542566
44Nitrogen metabolism_Homo sapiens_hsa009101.11932916
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11424872
46Proteasome_Homo sapiens_hsa030501.10574299
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10064443
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.09817549
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09385633
50Osteoclast differentiation_Homo sapiens_hsa043801.09318889
51Salmonella infection_Homo sapiens_hsa051321.07891433
52Glutathione metabolism_Homo sapiens_hsa004801.07320466
53Measles_Homo sapiens_hsa051621.07140596
54Caffeine metabolism_Homo sapiens_hsa002321.05538960
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05178566
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04929988
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.04330095
58Ribosome_Homo sapiens_hsa030101.03364355
59Allograft rejection_Homo sapiens_hsa053301.01817183
60Phagosome_Homo sapiens_hsa041451.01228685
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.98896362
62Legionellosis_Homo sapiens_hsa051340.96528261
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96043815
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92941677
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90611029
66Antigen processing and presentation_Homo sapiens_hsa046120.89809511
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89796377
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88536448
69Autoimmune thyroid disease_Homo sapiens_hsa053200.88454174
70Retinol metabolism_Homo sapiens_hsa008300.85613669
71Arachidonic acid metabolism_Homo sapiens_hsa005900.85101020
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84811001
73B cell receptor signaling pathway_Homo sapiens_hsa046620.84038650
74Tuberculosis_Homo sapiens_hsa051520.83807690
75T cell receptor signaling pathway_Homo sapiens_hsa046600.83169772
76Asthma_Homo sapiens_hsa053100.81183554
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.80378847
78Toxoplasmosis_Homo sapiens_hsa051450.79380728
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.77649499
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77458128
81Chemical carcinogenesis_Homo sapiens_hsa052040.76909768
82Hepatitis C_Homo sapiens_hsa051600.76116813
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75995875
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71775002
85Fat digestion and absorption_Homo sapiens_hsa049750.67302285
86Pentose phosphate pathway_Homo sapiens_hsa000300.65617563
87Vitamin digestion and absorption_Homo sapiens_hsa049770.64437422
88African trypanosomiasis_Homo sapiens_hsa051430.64188337
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64185013
90TNF signaling pathway_Homo sapiens_hsa046680.63217387
91Chemokine signaling pathway_Homo sapiens_hsa040620.62138510
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61699519
93Fatty acid degradation_Homo sapiens_hsa000710.61672211
94ABC transporters_Homo sapiens_hsa020100.61435030
95Apoptosis_Homo sapiens_hsa042100.61139683
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58932871
97Complement and coagulation cascades_Homo sapiens_hsa046100.58807914
98Fatty acid metabolism_Homo sapiens_hsa012120.57086433
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56795483
100Arginine and proline metabolism_Homo sapiens_hsa003300.56724139
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56710402
102Renal cell carcinoma_Homo sapiens_hsa052110.54739110
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.53123396
104Herpes simplex infection_Homo sapiens_hsa051680.52103291
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51197128
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49291459
107Vibrio cholerae infection_Homo sapiens_hsa051100.46364790
108Mineral absorption_Homo sapiens_hsa049780.46306504
109Influenza A_Homo sapiens_hsa051640.44548973
110Oxidative phosphorylation_Homo sapiens_hsa001900.44162712
111Butanoate metabolism_Homo sapiens_hsa006500.43506583
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43471462
113Platelet activation_Homo sapiens_hsa046110.42578858
114Regulation of autophagy_Homo sapiens_hsa041400.42499351
115Tryptophan metabolism_Homo sapiens_hsa003800.42184299
116* Endocytosis_Homo sapiens_hsa041440.40689016
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.39124130
118Hepatitis B_Homo sapiens_hsa051610.38158865
119FoxO signaling pathway_Homo sapiens_hsa040680.35664889
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35239818
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34742899
122Epstein-Barr virus infection_Homo sapiens_hsa051690.32921819
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28583853
124Prolactin signaling pathway_Homo sapiens_hsa049170.27537351
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.23721431
126Selenocompound metabolism_Homo sapiens_hsa004500.22713611
127Serotonergic synapse_Homo sapiens_hsa047260.21947139
128Dorso-ventral axis formation_Homo sapiens_hsa043200.19617951

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