ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indole-containing compound catabolic process (GO:0042436)	4.22385602
2	indolalkylamine catabolic process (GO:0046218)	4.22385602
3	tryptophan catabolic process (GO:0006569)	4.22385602
4	signal peptide processing (GO:0006465)	4.20553376
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.10492638
6	photoreceptor cell maintenance (GO:0045494)	4.05787466
7	indolalkylamine metabolic process (GO:0006586)	4.00394196
8	detection of light stimulus involved in sensory perception (GO:0050962)	3.98807940
9	detection of light stimulus involved in visual perception (GO:0050908)	3.98807940
10	piRNA metabolic process (GO:0034587)	3.91449666
11	DNA double-strand break processing (GO:0000729)	3.90552557
12	neural tube formation (GO:0001841)	3.79246879
13	kynurenine metabolic process (GO:0070189)	3.63866804
14	regulation of meiosis I (GO:0060631)	3.54575309
15	tryptophan metabolic process (GO:0006568)	3.53705298
16	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.40060511
17	DNA methylation involved in gamete generation (GO:0043046)	3.30712977
18	replication fork processing (GO:0031297)	3.29137454
19	protein K11-linked deubiquitination (GO:0035871)	3.27768204
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.26992045
21	reflex (GO:0060004)	3.24374638
22	protein prenylation (GO:0018342)	3.23623787
23	prenylation (GO:0097354)	3.23623787
24	respiratory chain complex IV assembly (GO:0008535)	3.19539472
25	meiotic chromosome segregation (GO:0045132)	3.17903693
26	establishment of protein localization to Golgi (GO:0072600)	3.14713450
27	indole-containing compound metabolic process (GO:0042430)	3.10798624
28	synapsis (GO:0007129)	3.07658162
29	cellular ketone body metabolic process (GO:0046950)	3.07130623
30	resolution of meiotic recombination intermediates (GO:0000712)	3.05448815
31	ketone body metabolic process (GO:1902224)	3.05317377
32	reciprocal meiotic recombination (GO:0007131)	3.04118661
33	reciprocal DNA recombination (GO:0035825)	3.04118661
34	cellular biogenic amine catabolic process (GO:0042402)	3.01412469
35	amine catabolic process (GO:0009310)	3.01412469
36	fucose catabolic process (GO:0019317)	3.00266631
37	L-fucose metabolic process (GO:0042354)	3.00266631
38	L-fucose catabolic process (GO:0042355)	3.00266631
39	amino acid salvage (GO:0043102)	2.93075692
40	L-methionine salvage (GO:0071267)	2.93075692
41	L-methionine biosynthetic process (GO:0071265)	2.93075692
42	platelet dense granule organization (GO:0060155)	2.90976816
43	male meiosis (GO:0007140)	2.90278517
44	regulation of acrosome reaction (GO:0060046)	2.90136533
45	double-strand break repair via homologous recombination (GO:0000724)	2.89975094
46	auditory receptor cell stereocilium organization (GO:0060088)	2.89747369
47	recombinational repair (GO:0000725)	2.87404245
48	response to pheromone (GO:0019236)	2.84939415
49	axoneme assembly (GO:0035082)	2.82541011
50	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.80974415
51	dopamine transport (GO:0015872)	2.80003965
52	regulation of hippo signaling (GO:0035330)	2.79323097
53	tachykinin receptor signaling pathway (GO:0007217)	2.78866252
54	cytochrome complex assembly (GO:0017004)	2.75921284
55	behavioral response to nicotine (GO:0035095)	2.73525489
56	retinal cone cell development (GO:0046549)	2.72760325
57	benzene-containing compound metabolic process (GO:0042537)	2.72296992
58	water-soluble vitamin biosynthetic process (GO:0042364)	2.70533344
59	DNA deamination (GO:0045006)	2.68192386
60	aromatic amino acid family catabolic process (GO:0009074)	2.65455670
61	branched-chain amino acid catabolic process (GO:0009083)	2.64358595
62	methionine biosynthetic process (GO:0009086)	2.64304033
63	righting reflex (GO:0060013)	2.62908107
64	regulation of glucokinase activity (GO:0033131)	2.60704248
65	regulation of hexokinase activity (GO:1903299)	2.60704248
66	proline transport (GO:0015824)	2.60600275
67	behavioral response to ethanol (GO:0048149)	2.60555252
68	kidney morphogenesis (GO:0060993)	2.59381486
69	snRNA transcription (GO:0009301)	2.58083959
70	positive regulation of meiosis (GO:0045836)	2.57059711
71	protein complex biogenesis (GO:0070271)	2.56942128
72	centriole replication (GO:0007099)	2.56121696
73	serotonin metabolic process (GO:0042428)	2.55511343
74	intraciliary transport (GO:0042073)	2.55362420
75	inner ear receptor stereocilium organization (GO:0060122)	2.55322596
76	acrosome assembly (GO:0001675)	2.55091241
77	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.54074472
78	cilium organization (GO:0044782)	2.53187650
79	thyroid hormone metabolic process (GO:0042403)	2.51179533
80	oxidative demethylation (GO:0070989)	2.50071297
81	protein targeting to Golgi (GO:0000042)	2.48128805
82	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46659362
83	cilium assembly (GO:0042384)	2.45983921
84	aromatic amino acid family metabolic process (GO:0009072)	2.44262220
85	cilium morphogenesis (GO:0060271)	2.43930988
86	male meiosis I (GO:0007141)	2.43103520
87	regulation of sarcomere organization (GO:0060297)	2.42990793
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.42000127
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42000127
90	cellular response to sterol (GO:0036315)	2.41664620
91	preassembly of GPI anchor in ER membrane (GO:0016254)	2.41537778
92	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.41419756
93	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.40908484
94	regulation of translation, ncRNA-mediated (GO:0045974)	2.40908484
95	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.40908484
96	positive regulation of meiotic cell cycle (GO:0051446)	2.39821864
97	monoubiquitinated protein deubiquitination (GO:0035520)	2.39187802
98	regulation of gene silencing by RNA (GO:0060966)	2.39175697
99	regulation of posttranscriptional gene silencing (GO:0060147)	2.39175697
100	regulation of gene silencing by miRNA (GO:0060964)	2.39175697

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.23460548
2	VDR_22108803_ChIP-Seq_LS180_Human	3.14725245
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08438835
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.92099778
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79562296
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.68535262
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65090965
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61529101
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.53637191
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52256081
11	FUS_26573619_Chip-Seq_HEK293_Human	2.37562811
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.33026502
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30824083
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.27857044
15	P300_19829295_ChIP-Seq_ESCs_Human	2.25051489
16	EWS_26573619_Chip-Seq_HEK293_Human	2.22613362
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07549976
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.04425310
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.90213147
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87590099
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87182460
22	STAT3_23295773_ChIP-Seq_U87_Human	1.77164881
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74878847
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.73239239
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72621754
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72472946
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68131571
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.67823654
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64177467
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63970198
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62403333
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.62403333
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.62345405
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61480817
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57565749
36	TCF4_23295773_ChIP-Seq_U87_Human	1.54825066
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52697235
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52395086
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51581562
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.51500962
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49340744
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48973881
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47659698
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45405488
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44526176
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44526176
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44315789
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.43595383
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43506808
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42347181
51	AR_25329375_ChIP-Seq_VCAP_Human	1.41090361
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40599175
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.38993775
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.37082443
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36659909
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35557816
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34181544
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33055298
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32633042
60	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31810660
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31418699
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.30982686
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30377034
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.30250173
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28961404
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28803538
67	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24845708
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24664132
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22620556
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21645573
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19671617
72	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19343681
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.18454200
74	P300_18555785_Chip-Seq_ESCs_Mouse	1.17396045
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17367078
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17367078
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16168316
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14187835
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14187835
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.13930628
81	EZH2_22144423_ChIP-Seq_EOC_Human	1.13403218
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13339626
83	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13170609
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12948821
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11238562
86	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11148615
87	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11043866
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09411303
89	MYC_18940864_ChIP-ChIP_HL60_Human	1.08703733
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08114221
91	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.07829296
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07372055
93	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06164541
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02235130
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01871075
96	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01745142
97	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00878911
98	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.00567470
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00015554
100	AR_20517297_ChIP-Seq_VCAP_Human	0.99809964

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.60374842
2	MP0003195_calcinosis	3.16196682
3	MP0008057_abnormal_DNA_replication	3.14734037
4	MP0002102_abnormal_ear_morphology	2.80689230
5	MP0000372_irregular_coat_pigmentation	2.60863213
6	MP0005551_abnormal_eye_electrophysiolog	2.49107757
7	MP0000569_abnormal_digit_pigmentation	2.24994397
8	MP0004147_increased_porphyrin_level	2.18305763
9	MP0003718_maternal_effect	2.12445711
10	MP0003950_abnormal_plasma_membrane	2.09203770
11	MP0008058_abnormal_DNA_repair	2.06460056
12	MP0005645_abnormal_hypothalamus_physiol	2.05153258
13	MP0002736_abnormal_nociception_after	1.99310300
14	MP0005646_abnormal_pituitary_gland	1.96817778
15	MP0006276_abnormal_autonomic_nervous	1.83860901
16	MP0005253_abnormal_eye_physiology	1.74067559
17	MP0009046_muscle_twitch	1.73561850
18	MP0000427_abnormal_hair_cycle	1.72532443
19	MP0002938_white_spotting	1.72150504
20	MP0002837_dystrophic_cardiac_calcinosis	1.67350124
21	MP0003646_muscle_fatigue	1.64666224
22	MP0001968_abnormal_touch/_nociception	1.64461094
23	MP0003787_abnormal_imprinting	1.63554507
24	MP0001764_abnormal_homeostasis	1.60326684
25	MP0006072_abnormal_retinal_apoptosis	1.58949128
26	MP0006292_abnormal_olfactory_placode	1.58469536
27	MP0004043_abnormal_pH_regulation	1.56730489
28	MP0001485_abnormal_pinna_reflex	1.54170671
29	MP0001984_abnormal_olfaction	1.53242016
30	MP0003806_abnormal_nucleotide_metabolis	1.50574321
31	MP0005410_abnormal_fertilization	1.49746561
32	MP0005075_abnormal_melanosome_morpholog	1.48877586
33	MP0008995_early_reproductive_senescence	1.47244939
34	MP0008872_abnormal_physiological_respon	1.44977955
35	MP0006054_spinal_hemorrhage	1.38739047
36	MP0002876_abnormal_thyroid_physiology	1.38642696
37	MP0001529_abnormal_vocalization	1.36338370
38	MP0001501_abnormal_sleep_pattern	1.36198150
39	MP0003136_yellow_coat_color	1.35730762
40	MP0002254_reproductive_system_inflammat	1.30016122
41	MP0004133_heterotaxia	1.27521788
42	MP0004215_abnormal_myocardial_fiber	1.27166596
43	MP0005174_abnormal_tail_pigmentation	1.25730188
44	MP0000631_abnormal_neuroendocrine_gland	1.24998766
45	MP0002160_abnormal_reproductive_system	1.24952381
46	MP0009745_abnormal_behavioral_response	1.23510335
47	MP0003698_abnormal_male_reproductive	1.23023705
48	MP0001929_abnormal_gametogenesis	1.22791557
49	MP0009697_abnormal_copulation	1.20992950
50	MP0003890_abnormal_embryonic-extraembry	1.19102895
51	MP0010094_abnormal_chromosome_stability	1.18510367
52	MP0004142_abnormal_muscle_tone	1.18393957
53	MP0008875_abnormal_xenobiotic_pharmacok	1.15759288
54	MP0005395_other_phenotype	1.15026359
55	MP0002138_abnormal_hepatobiliary_system	1.14823235
56	MP0010386_abnormal_urinary_bladder	1.14325119
57	MP0003786_premature_aging	1.13045607
58	MP0005379_endocrine/exocrine_gland_phen	1.12924776
59	MP0006036_abnormal_mitochondrial_physio	1.12330963
60	MP0000383_abnormal_hair_follicle	1.11872354
61	MP0002638_abnormal_pupillary_reflex	1.09672953
62	MP0003252_abnormal_bile_duct	1.09349243
63	MP0003119_abnormal_digestive_system	1.09080739
64	MP0000653_abnormal_sex_gland	1.08528258
65	MP0005266_abnormal_metabolism	1.06999046
66	MP0003943_abnormal_hepatobiliary_system	1.06884124
67	MP0001486_abnormal_startle_reflex	1.05763122
68	MP0005389_reproductive_system_phenotype	1.03400065
69	MP0005084_abnormal_gallbladder_morpholo	1.02659272
70	MP0005647_abnormal_sex_gland	1.02168385
71	MP0002090_abnormal_vision	1.01210116
72	MP0005332_abnormal_amino_acid	1.00254444
73	MP0002210_abnormal_sex_determination	0.99278873
74	MP0001145_abnormal_male_reproductive	0.99273533
75	MP0002234_abnormal_pharynx_morphology	0.97170365
76	MP0005367_renal/urinary_system_phenotyp	0.96305695
77	MP0000516_abnormal_urinary_system	0.96305695
78	MP0003937_abnormal_limbs/digits/tail_de	0.93823932
79	MP0000639_abnormal_adrenal_gland	0.90907223
80	MP0005386_behavior/neurological_phenoty	0.90712254
81	MP0004924_abnormal_behavior	0.90712254
82	MP0004085_abnormal_heartbeat	0.90533103
83	MP0005220_abnormal_exocrine_pancreas	0.90015447
84	MP0002557_abnormal_social/conspecific_i	0.89125947
85	MP0002928_abnormal_bile_duct	0.87255680
86	MP0004145_abnormal_muscle_electrophysio	0.87197278
87	MP0003880_abnormal_central_pattern	0.85916998
88	MP0002272_abnormal_nervous_system	0.85610944
89	MP0003011_delayed_dark_adaptation	0.83905465
90	MP0000538_abnormal_urinary_bladder	0.83760371
91	MP0003941_abnormal_skin_development	0.83533161
92	MP0006035_abnormal_mitochondrial_morpho	0.82803278
93	MP0000647_abnormal_sebaceous_gland	0.82524027
94	MP0002163_abnormal_gland_morphology	0.82154091
95	MP0002735_abnormal_chemical_nociception	0.81956877
96	MP0004019_abnormal_vitamin_homeostasis	0.81799433
97	MP0005085_abnormal_gallbladder_physiolo	0.81148439
98	MP0003137_abnormal_impulse_conducting	0.80675955
99	MP0000230_abnormal_systemic_arterial	0.80483695
100	MP0001119_abnormal_female_reproductive	0.80075829

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.88350585
2	True hermaphroditism (HP:0010459)	3.59189012
3	Pancreatic fibrosis (HP:0100732)	3.57200125
4	Attenuation of retinal blood vessels (HP:0007843)	3.49617637
5	Congenital stationary night blindness (HP:0007642)	3.45330418
6	Abnormality of the renal cortex (HP:0011035)	3.18773327
7	Medial flaring of the eyebrow (HP:0010747)	3.14365809
8	Gaze-evoked nystagmus (HP:0000640)	3.06049857
9	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.01530452
10	Hypoplasia of the fovea (HP:0007750)	3.01530452
11	Central scotoma (HP:0000603)	2.97982049
12	Renal cortical cysts (HP:0000803)	2.95216116
13	Abnormality of midbrain morphology (HP:0002418)	2.94053152
14	Molar tooth sign on MRI (HP:0002419)	2.94053152
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.83919189
16	Nephronophthisis (HP:0000090)	2.82657516
17	Chronic hepatic failure (HP:0100626)	2.79686897
18	Intestinal atresia (HP:0011100)	2.66105769
19	Abnormality of the fovea (HP:0000493)	2.63893353
20	Abnormality of the renal medulla (HP:0100957)	2.63754848
21	Abolished electroretinogram (ERG) (HP:0000550)	2.62948456
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.58388848
23	Nephrogenic diabetes insipidus (HP:0009806)	2.57774088
24	Abnormality of macular pigmentation (HP:0008002)	2.54079351
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.51984552
26	Congenital primary aphakia (HP:0007707)	2.51003365
27	Tubulointerstitial nephritis (HP:0001970)	2.47897481
28	Febrile seizures (HP:0002373)	2.43226996
29	Gait imbalance (HP:0002141)	2.41442849
30	Hyperventilation (HP:0002883)	2.39344341
31	Cystic liver disease (HP:0006706)	2.39301973
32	Congenital sensorineural hearing impairment (HP:0008527)	2.38550332
33	Progressive cerebellar ataxia (HP:0002073)	2.35999888
34	Hypothermia (HP:0002045)	2.34886607
35	Genital tract atresia (HP:0001827)	2.31546733
36	Progressive inability to walk (HP:0002505)	2.26277226
37	Constricted visual fields (HP:0001133)	2.25596065
38	Hyperglycinuria (HP:0003108)	2.22276987
39	Vaginal atresia (HP:0000148)	2.18583812
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17564303
41	Decreased central vision (HP:0007663)	2.15369144
42	Hypoglycemic coma (HP:0001325)	2.13244373
43	Pancreatic islet-cell hyperplasia (HP:0004510)	2.12514019
44	Inability to walk (HP:0002540)	2.11800059
45	Colon cancer (HP:0003003)	2.11053860
46	Neoplasm of the adrenal cortex (HP:0100641)	2.10788529
47	Scotoma (HP:0000575)	2.10230650
48	Volvulus (HP:0002580)	2.10146128
49	Genetic anticipation (HP:0003743)	2.09838243
50	Methylmalonic aciduria (HP:0012120)	2.09144395
51	Hyperalaninemia (HP:0003348)	2.08933156
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08933156
53	Abnormality of alanine metabolism (HP:0010916)	2.08933156
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08165838
55	Type II lissencephaly (HP:0007260)	2.07159065
56	Cerebellar dysplasia (HP:0007033)	2.06789985
57	Male pseudohermaphroditism (HP:0000037)	2.06240036
58	Abnormality of chromosome stability (HP:0003220)	2.04475166
59	Hyperglycinemia (HP:0002154)	2.03951679
60	Severe visual impairment (HP:0001141)	2.03926648
61	Increased CSF lactate (HP:0002490)	2.03851915
62	Abnormality of the labia minora (HP:0012880)	2.02475186
63	Ketoacidosis (HP:0001993)	2.00593621
64	Small hand (HP:0200055)	1.99461475
65	Congenital hepatic fibrosis (HP:0002612)	1.99399523
66	Proximal tubulopathy (HP:0000114)	1.99009161
67	Astigmatism (HP:0000483)	1.98904928
68	Methylmalonic acidemia (HP:0002912)	1.98764468
69	Acute encephalopathy (HP:0006846)	1.98696935
70	Sclerocornea (HP:0000647)	1.97546233
71	Increased corneal curvature (HP:0100692)	1.96305554
72	Keratoconus (HP:0000563)	1.96305554
73	Progressive macrocephaly (HP:0004481)	1.94299915
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93791430
75	Abnormality of glycine metabolism (HP:0010895)	1.93791430
76	Acute necrotizing encephalopathy (HP:0006965)	1.93349454
77	Sloping forehead (HP:0000340)	1.91181691
78	Facial diplegia (HP:0001349)	1.90526091
79	Large for gestational age (HP:0001520)	1.90269447
80	Poor coordination (HP:0002370)	1.88262134
81	Abnormality of the pons (HP:0007361)	1.87970672
82	Short tibia (HP:0005736)	1.87742070
83	Furrowed tongue (HP:0000221)	1.87709866
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87364899
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87027139
86	Absent speech (HP:0001344)	1.85122724
87	Anencephaly (HP:0002323)	1.84149018
88	Hypoplasia of the pons (HP:0012110)	1.82139345
89	Aplasia/Hypoplasia of the macula (HP:0008059)	1.81916123
90	Lissencephaly (HP:0001339)	1.79532274
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79154832
92	Tubular atrophy (HP:0000092)	1.77644020
93	Postaxial foot polydactyly (HP:0001830)	1.77243171
94	Hepatic necrosis (HP:0002605)	1.76896812
95	Bifid tongue (HP:0010297)	1.75942301
96	Glioma (HP:0009733)	1.74010656
97	Enlarged kidneys (HP:0000105)	1.73827160
98	Retinitis pigmentosa (HP:0000510)	1.72821364
99	Albinism (HP:0001022)	1.72430696
100	Optic nerve hypoplasia (HP:0000609)	1.71373676

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.41495707
2	ACVR1B	3.23589418
3	BMPR1B	3.12844014
4	MAP4K2	2.97408426
5	TRIM28	2.71696487
6	NUAK1	2.60830383
7	EIF2AK3	2.38068786
8	WNK3	2.34212356
9	INSRR	2.31270284
10	ADRBK2	1.97811558
11	STK38L	1.87526598
12	GRK1	1.86884910
13	MST4	1.73437439
14	TNIK	1.73161018
15	BRSK2	1.68553977
16	ZAK	1.64878529
17	BCR	1.64224297
18	PINK1	1.62725856
19	CASK	1.50545169
20	MKNK2	1.48132901
21	OXSR1	1.41019590
22	TAOK3	1.34603699
23	MKNK1	1.30524062
24	MAP3K4	1.28218142
25	PIK3CG	1.23976847
26	PLK4	1.19373362
27	STK3	1.17354874
28	PDK2	1.12805021
29	CSNK1G1	1.06477476
30	AKT3	1.05695270
31	PBK	1.03563915
32	STK39	1.02107193
33	TGFBR1	0.97868011
34	FER	0.97425131
35	MAPK13	0.96661845
36	SIK3	0.94959695
37	TEC	0.94944373
38	PTK2B	0.94491821
39	PAK3	0.93890122
40	ERBB3	0.91986489
41	PNCK	0.91196512
42	PLK3	0.88811536
43	PLK2	0.88655687
44	DAPK2	0.86839829
45	CSNK1G3	0.86299870
46	CSNK1G2	0.84270241
47	PRKCE	0.81186581
48	WEE1	0.80984144
49	ADRBK1	0.79805024
50	MUSK	0.79744312
51	CSNK1A1L	0.76350654
52	EIF2AK1	0.75616047
53	NEK1	0.71137749
54	FLT3	0.67034821
55	NTRK3	0.66659342
56	PRKCG	0.64711721
57	NLK	0.61307020
58	PLK1	0.61247706
59	FGFR2	0.59189698
60	TAF1	0.55696343
61	VRK2	0.54872579
62	EIF2AK2	0.54480275
63	TLK1	0.53419456
64	VRK1	0.51872678
65	TIE1	0.50675901
66	MARK3	0.49665275
67	BMPR2	0.49619055
68	TNK2	0.48774314
69	TRPM7	0.48680567
70	EPHA4	0.48372355
71	MAP2K7	0.48347076
72	ATM	0.47971476
73	MAPKAPK5	0.47589104
74	TTK	0.45929912
75	OBSCN	0.45252240
76	PRKAA2	0.45130479
77	ATR	0.41504632
78	CAMK2A	0.41278520
79	LATS1	0.41214765
80	BUB1	0.39007263
81	STK16	0.38523420
82	STK24	0.38437302
83	BCKDK	0.37552391
84	TXK	0.37002077
85	CHEK2	0.35635386
86	ERBB4	0.34604213
87	MELK	0.34533261
88	PRKACA	0.34164326
89	CSNK1D	0.33280393
90	MAP3K12	0.31860769
91	CSNK1A1	0.31278459
92	NME1	0.30770593
93	STK38	0.30311552
94	STK11	0.30044989
95	PKN1	0.29063588
96	PRKACB	0.28896365
97	PRKAA1	0.27647770
98	RPS6KA5	0.27396757
99	GRK5	0.27293646
100	PIK3CA	0.27200198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.78203918
2	Phototransduction_Homo sapiens_hsa04744	2.34753996
3	Homologous recombination_Homo sapiens_hsa03440	2.34501489
4	Propanoate metabolism_Homo sapiens_hsa00640	2.32734901
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26144083
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25281646
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23018583
8	Protein export_Homo sapiens_hsa03060	2.18950421
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10485276
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.09680354
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.06825576
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.03250548
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.03143329
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.97580680
15	Basal transcription factors_Homo sapiens_hsa03022	1.93259154
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88772564
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83737601
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.81004332
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79299940
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.75936662
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68120869
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.60637281
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60220866
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.58216542
25	Olfactory transduction_Homo sapiens_hsa04740	1.57704372
26	ABC transporters_Homo sapiens_hsa02010	1.57489531
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.44279060
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42627314
29	RNA polymerase_Homo sapiens_hsa03020	1.40004473
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.35694341
31	Retinol metabolism_Homo sapiens_hsa00830	1.35499314
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.33838468
33	Peroxisome_Homo sapiens_hsa04146	1.30478500
34	Caffeine metabolism_Homo sapiens_hsa00232	1.27098533
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26858682
36	RNA degradation_Homo sapiens_hsa03018	1.25952020
37	Nicotine addiction_Homo sapiens_hsa05033	1.25737935
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23767684
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23197675
40	One carbon pool by folate_Homo sapiens_hsa00670	1.19203262
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18776293
42	Regulation of autophagy_Homo sapiens_hsa04140	1.15728027
43	Taste transduction_Homo sapiens_hsa04742	1.14554635
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.11530813
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09707037
46	Fatty acid elongation_Homo sapiens_hsa00062	1.05583786
47	Proteasome_Homo sapiens_hsa03050	1.02332119
48	Circadian rhythm_Homo sapiens_hsa04710	0.98757085
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97677113
50	Fatty acid degradation_Homo sapiens_hsa00071	0.97607251
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97157651
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95768807
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94158066
54	Serotonergic synapse_Homo sapiens_hsa04726	0.93953611
55	Purine metabolism_Homo sapiens_hsa00230	0.92007161
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.91367075
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.87241232
58	Glutathione metabolism_Homo sapiens_hsa00480	0.83212399
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77913279
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77671808
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77480641
62	Morphine addiction_Homo sapiens_hsa05032	0.77223063
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75804849
64	Metabolic pathways_Homo sapiens_hsa01100	0.75488308
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74837271
66	Insulin secretion_Homo sapiens_hsa04911	0.74659656
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73844825
68	Histidine metabolism_Homo sapiens_hsa00340	0.71441785
69	RNA transport_Homo sapiens_hsa03013	0.71092535
70	Parkinsons disease_Homo sapiens_hsa05012	0.69657282
71	Salivary secretion_Homo sapiens_hsa04970	0.69195404
72	Sulfur metabolism_Homo sapiens_hsa00920	0.68094446
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.67915596
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.67686530
75	GABAergic synapse_Homo sapiens_hsa04727	0.67012050
76	Mismatch repair_Homo sapiens_hsa03430	0.65512664
77	Huntingtons disease_Homo sapiens_hsa05016	0.64670694
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64381503
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63355880
80	Circadian entrainment_Homo sapiens_hsa04713	0.62849249
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.62753832
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.61464783
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.61139371
84	Lysine degradation_Homo sapiens_hsa00310	0.59477585
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57484079
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57188443
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56483591
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56243557
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55590569
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55447043
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.55035340
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52173000
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52123240
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51910078
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.47190705
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43439532
97	Mineral absorption_Homo sapiens_hsa04978	0.41508651
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40830666
99	Long-term depression_Homo sapiens_hsa04730	0.40645452
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.40234221

CHMP1B2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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