CHMP2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36822376
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.22562542
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.99904557
4ATP synthesis coupled proton transport (GO:0015986)5.99904557
5respiratory electron transport chain (GO:0022904)5.41271482
6electron transport chain (GO:0022900)5.28141007
7protein neddylation (GO:0045116)4.83452497
8axon ensheathment in central nervous system (GO:0032291)4.41611373
9central nervous system myelination (GO:0022010)4.41611373
10fatty acid elongation (GO:0030497)4.31639297
11sequestering of actin monomers (GO:0042989)4.06523027
12chaperone-mediated protein transport (GO:0072321)3.81245005
13long-chain fatty acid biosynthetic process (GO:0042759)3.67310653
14hydrogen ion transmembrane transport (GO:1902600)3.62421315
15viral protein processing (GO:0019082)3.49275564
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43821856
17signal peptide processing (GO:0006465)3.43350862
18protein maturation by protein folding (GO:0022417)3.40500446
19aldehyde catabolic process (GO:0046185)3.39758067
20protein complex biogenesis (GO:0070271)3.38530627
21proton transport (GO:0015992)3.36483015
22viral transcription (GO:0019083)3.34520581
23response to interferon-beta (GO:0035456)3.34115827
24hydrogen transport (GO:0006818)3.29327080
25neutrophil activation involved in immune response (GO:0002283)3.28193175
26amyloid precursor protein metabolic process (GO:0042982)3.27308526
27amyloid precursor protein catabolic process (GO:0042987)3.24887526
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20132149
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.20132149
30NADH dehydrogenase complex assembly (GO:0010257)3.20132149
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.20064031
32phagosome maturation (GO:0090382)3.17622753
33ATP biosynthetic process (GO:0006754)3.16895784
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12059924
35nucleotide transmembrane transport (GO:1901679)3.09902728
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08619337
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07344355
38translational termination (GO:0006415)3.07307087
39platelet dense granule organization (GO:0060155)3.05943665
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05781803
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03898231
42cholesterol biosynthetic process (GO:0006695)3.02858211
43regulation of autophagic vacuole assembly (GO:2000785)3.02736196
44positive regulation of TOR signaling (GO:0032008)2.99607770
45ATP hydrolysis coupled proton transport (GO:0015991)2.92103899
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.92103899
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90987358
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90987358
49cellular response to interferon-beta (GO:0035458)2.90767168
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90363223
51purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.89283234
52establishment of protein localization to mitochondrion (GO:0072655)2.88657501
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87115684
54protein deneddylation (GO:0000338)2.87098057
55mitochondrial respiratory chain complex assembly (GO:0033108)2.86554081
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85932579
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85932579
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85932579
59translational elongation (GO:0006414)2.85831038
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83404692
61regulation of mitochondrial translation (GO:0070129)2.82916920
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82457208
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82457208
64metallo-sulfur cluster assembly (GO:0031163)2.82379730
65iron-sulfur cluster assembly (GO:0016226)2.82379730
66DNA deamination (GO:0045006)2.81273546
67* viral life cycle (GO:0019058)2.79666176
68proteasome assembly (GO:0043248)2.78064508
69regulation of vacuole organization (GO:0044088)2.78050791
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77482547
71negative regulation of ligase activity (GO:0051352)2.77482547
72cullin deneddylation (GO:0010388)2.77465328
73respiratory chain complex IV assembly (GO:0008535)2.76077750
74sterol biosynthetic process (GO:0016126)2.74877470
75GTP biosynthetic process (GO:0006183)2.73914352
76virion assembly (GO:0019068)2.72940896
77cytochrome complex assembly (GO:0017004)2.71710027
78ribosomal small subunit assembly (GO:0000028)2.71645840
79ribosomal small subunit biogenesis (GO:0042274)2.71127783
80protein localization to mitochondrion (GO:0070585)2.71075650
81regulation of cellular amino acid metabolic process (GO:0006521)2.71066280
82signal transduction involved in DNA damage checkpoint (GO:0072422)2.68394610
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68394610
84negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67661527
85positive regulation of monocyte chemotaxis (GO:0090026)2.66952557
86purine deoxyribonucleotide catabolic process (GO:0009155)2.66877939
87GPI anchor biosynthetic process (GO:0006506)2.66239934
88purine deoxyribonucleotide metabolic process (GO:0009151)2.65469472
89respiratory burst (GO:0045730)2.64905872
90eosinophil chemotaxis (GO:0048245)2.63680232
91cytidine metabolic process (GO:0046087)2.63522218
92cytidine catabolic process (GO:0006216)2.63522218
93cytidine deamination (GO:0009972)2.63522218
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.63493443
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62432528
96hydrogen peroxide catabolic process (GO:0042744)2.61073014
97positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.59798221
98cellular copper ion homeostasis (GO:0006878)2.58129603
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.57498443
100cotranslational protein targeting to membrane (GO:0006613)2.57363888
101substantia nigra development (GO:0021762)2.55928542
102inner mitochondrial membrane organization (GO:0007007)2.54006337
103autophagic vacuole fusion (GO:0000046)2.53753591
104intracellular protein transmembrane import (GO:0044743)2.51939164
105cellular response to zinc ion (GO:0071294)2.51845855
106protein targeting to ER (GO:0045047)2.50355199
107ubiquinone biosynthetic process (GO:0006744)2.50200364
108glutathione derivative biosynthetic process (GO:1901687)2.49335102
109glutathione derivative metabolic process (GO:1901685)2.49335102
110protein localization to endoplasmic reticulum (GO:0070972)2.49314770
111isoprenoid biosynthetic process (GO:0008299)2.49301549
112actin nucleation (GO:0045010)2.49247061
113glutathione biosynthetic process (GO:0006750)2.48560933
114transferrin transport (GO:0033572)2.47059651
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46987753
116cofactor catabolic process (GO:0051187)2.46807644
117hydrogen peroxide biosynthetic process (GO:0050665)2.46015638
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45332882
119positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.43770707
120guanosine-containing compound biosynthetic process (GO:1901070)2.43645635
121eosinophil migration (GO:0072677)2.43250814
122antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.43147025
123copper ion homeostasis (GO:0055070)2.39912355
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39864086
125regulation of metalloenzyme activity (GO:0048552)2.39626621
126GDP-mannose metabolic process (GO:0019673)2.35603412
127regulation of cellular amine metabolic process (GO:0033238)2.34355363
128nonribosomal peptide biosynthetic process (GO:0019184)2.32116562
129GPI anchor metabolic process (GO:0006505)2.31232607
130positive regulation of cellular amine metabolic process (GO:0033240)2.29376729
131lipoxygenase pathway (GO:0019372)2.29182863
132superoxide anion generation (GO:0042554)2.28332388
133glutathione metabolic process (GO:0006749)2.28278533
134ferric iron transport (GO:0015682)2.28161719
135trivalent inorganic cation transport (GO:0072512)2.28161719
136oxidative phosphorylation (GO:0006119)2.27395042
137regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.26440789
138negative regulation of acute inflammatory response (GO:0002674)2.25039778
139long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.24155982
140nucleoside triphosphate biosynthetic process (GO:0009142)2.23857904
141fatty-acyl-CoA metabolic process (GO:0035337)2.23008320
142hydrogen peroxide metabolic process (GO:0042743)2.22926239
143cellular response to oxygen radical (GO:0071450)2.20750102
144removal of superoxide radicals (GO:0019430)2.20750102
145cellular response to superoxide (GO:0071451)2.20750102
146dopamine transport (GO:0015872)2.20499207
147mitochondrial transport (GO:0006839)2.18993832
148protein targeting to mitochondrion (GO:0006626)2.18372382
149cyclooxygenase pathway (GO:0019371)2.18117023
150dopamine biosynthetic process (GO:0042416)2.17683432
151DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.17565210
152virion attachment to host cell (GO:0019062)2.16070330
153adhesion of symbiont to host cell (GO:0044650)2.16070330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43678001
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.33765018
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26101316
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25358466
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16066163
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15646923
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.91728538
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81894852
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.68118503
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59694135
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56842137
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.31228951
13VDR_22108803_ChIP-Seq_LS180_Human2.29364609
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22379942
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14590706
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03310106
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00653723
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94190672
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93947048
20BCL6_27268052_Chip-Seq_Bcells_Human1.91938686
21* XRN2_22483619_ChIP-Seq_HELA_Human1.84394094
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83104909
23* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80334712
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.77736498
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.76882905
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74429646
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73767826
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.71527956
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70119106
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69895091
31LXR_22292898_ChIP-Seq_THP-1_Human1.69784565
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69032309
33VDR_21846776_ChIP-Seq_THP-1_Human1.68089862
34BCOR_27268052_Chip-Seq_Bcells_Human1.63344034
35* GABP_19822575_ChIP-Seq_HepG2_Human1.62815095
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62181724
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61812465
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61734132
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.56868599
40* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55219107
41* P68_20966046_ChIP-Seq_HELA_Human1.55126658
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53254378
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49563661
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.45761351
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43894860
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.43251686
47E2F1_20622854_ChIP-Seq_HELA_Human1.43216776
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37357435
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36969211
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36840048
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36531406
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36216289
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35676711
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35659445
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34755099
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34228090
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32701975
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.31957220
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.31346235
60SA1_27219007_Chip-Seq_Bcells_Human1.29995174
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29563999
62MAF_26560356_Chip-Seq_TH2_Human1.28915543
63* PHF8_20622854_ChIP-Seq_HELA_Human1.28623017
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28400985
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27400162
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26152671
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.25450076
68* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24419264
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24267924
70* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24104836
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24047436
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23723560
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23290418
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23077549
75HTT_18923047_ChIP-ChIP_STHdh_Human1.22996151
76TAF15_26573619_Chip-Seq_HEK293_Human1.22381370
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22150023
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.21446753
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20409644
80ZNF263_19887448_ChIP-Seq_K562_Human1.19676497
81STAT1_20625510_ChIP-Seq_HELA_Human1.19018663
82P300_27268052_Chip-Seq_Bcells_Human1.17192704
83* SOX2_20726797_ChIP-Seq_SW620_Human1.17001700
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16971714
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16971714
86SPI1_23547873_ChIP-Seq_NB4_Human1.16299908
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16253494
88ER_23166858_ChIP-Seq_MCF-7_Human1.16229275
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12782764
90FOXP3_21729870_ChIP-Seq_TREG_Human1.12493677
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12187531
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12136947
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11226570
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10432239
95VDR_24763502_ChIP-Seq_THP-1_Human1.09877169
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09841875
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08222665
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06798656
99ELK1_19687146_ChIP-ChIP_HELA_Human1.06508243
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05487935
101* UTX_26944678_Chip-Seq_JUKART_Human1.04889384
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04127651
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03532829
104IRF1_19129219_ChIP-ChIP_H3396_Human1.02775404
105RACK7_27058665_Chip-Seq_MCF-7_Human1.02616602
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01916265
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00153254
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00030024
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99997669
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99728838
111ERA_21632823_ChIP-Seq_H3396_Human0.99280890
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99246962
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99002348
114MAF_26560356_Chip-Seq_TH1_Human0.98760432
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98301732
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97259695
117* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96035750
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91767282
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90543256
120NANOG_20526341_ChIP-Seq_ESCs_Human0.90243145
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.89672647
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89383271
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89236537
124NANOG_19829295_ChIP-Seq_ESCs_Human0.87465245
125SOX2_19829295_ChIP-Seq_ESCs_Human0.87465245
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87013850
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86129478
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85901602
129VDR_23849224_ChIP-Seq_CD4+_Human0.85155977
130EGR1_19032775_ChIP-ChIP_M12_Human0.84932272
131IRF8_27001747_Chip-Seq_BMDM_Mouse0.84357027
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82311006
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81482862
134DCP1A_22483619_ChIP-Seq_HELA_Human0.80981501
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.80868923
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80531993
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80515955
138* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79873467
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79861712
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.79076915
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78744929
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78303628
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78189913
144ERG_20517297_ChIP-Seq_VCAP_Human0.77177943
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77125034
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76968738
147NCOR_22424771_ChIP-Seq_293T_Human0.75941858
148HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73926653
149ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73535807
150CTCF_20526341_ChIP-Seq_ESCs_Human0.73429006
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73353865
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72800849
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.72744226
154YY1_21170310_ChIP-Seq_MESCs_Mouse0.72581444
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72343676
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.72176094
157* AR_20517297_ChIP-Seq_VCAP_Human0.70967921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.82475505
2MP0002148_abnormal_hypersensitivity_rea2.70644938
3MP0005058_abnormal_lysosome_morphology2.60580495
4MP0003806_abnormal_nucleotide_metabolis2.57457663
5MP0003724_increased_susceptibility_to2.53600274
6MP0003186_abnormal_redox_activity2.51740512
7MP0009785_altered_susceptibility_to2.50317327
8MP0001529_abnormal_vocalization2.42811335
9MP0000920_abnormal_myelination2.37172988
10MP0003880_abnormal_central_pattern2.36563906
11MP0006082_CNS_inflammation2.31163439
12MP0002132_abnormal_respiratory_system2.27789278
13MP0008260_abnormal_autophagy2.26298651
14MP0010386_abnormal_urinary_bladder2.24294157
15MP0001905_abnormal_dopamine_level2.20138577
16MP0002876_abnormal_thyroid_physiology2.10411793
17MP0002653_abnormal_ependyma_morphology2.09842463
18MP0005084_abnormal_gallbladder_morpholo2.05915129
19MP0003136_yellow_coat_color1.94519681
20MP0001835_abnormal_antigen_presentation1.90763989
21MP0003950_abnormal_plasma_membrane1.90551476
22MP0003303_peritoneal_inflammation1.85885886
23MP0009840_abnormal_foam_cell1.81817506
24MP0005365_abnormal_bile_salt1.72254167
25MP0009379_abnormal_foot_pigmentation1.69218862
26MP0005000_abnormal_immune_tolerance1.65286947
27MP0004381_abnormal_hair_follicle1.63743925
28MP0005025_abnormal_response_to1.62825155
29MP0003329_amyloid_beta_deposits1.57746168
30MP0002837_dystrophic_cardiac_calcinosis1.56102297
31MP0003436_decreased_susceptibility_to1.55393034
32MP0001756_abnormal_urination1.53537459
33MP0004782_abnormal_surfactant_physiolog1.52982466
34MP0002419_abnormal_innate_immunity1.52195745
35MP0008875_abnormal_xenobiotic_pharmacok1.50521802
36MP0004043_abnormal_pH_regulation1.50367442
37MP0006035_abnormal_mitochondrial_morpho1.48531341
38MP0002638_abnormal_pupillary_reflex1.44956266
39MP0003690_abnormal_glial_cell1.44777361
40MP0005451_abnormal_body_composition1.42831243
41MP0005379_endocrine/exocrine_gland_phen1.42748590
42MP0005310_abnormal_salivary_gland1.40902258
43MP0002163_abnormal_gland_morphology1.39209748
44MP0002295_abnormal_pulmonary_circulatio1.38848809
45MP0000604_amyloidosis1.38520464
46MP0001542_abnormal_bone_strength1.35874846
47MP0005166_decreased_susceptibility_to1.34253479
48MP0003191_abnormal_cellular_cholesterol1.30527480
49MP0005671_abnormal_response_to1.29595131
50MP0010155_abnormal_intestine_physiology1.29139721
51MP0006036_abnormal_mitochondrial_physio1.28018285
52MP0006276_abnormal_autonomic_nervous1.28007369
53MP0001790_abnormal_immune_system1.27381515
54MP0005387_immune_system_phenotype1.27381515
55MP0008004_abnormal_stomach_pH1.24042879
56MP0000372_irregular_coat_pigmentation1.23772422
57MP0005423_abnormal_somatic_nervous1.23723302
58MP0000750_abnormal_muscle_regeneration1.23420463
59MP0003011_delayed_dark_adaptation1.22336490
60MP0002796_impaired_skin_barrier1.21180140
61MP0004142_abnormal_muscle_tone1.20773565
62MP0004510_myositis1.19359584
63MP0005636_abnormal_mineral_homeostasis1.19148471
64MP0005171_absent_coat_pigmentation1.19137065
65MP0009764_decreased_sensitivity_to1.19023605
66MP0005408_hypopigmentation1.18613563
67MP0005174_abnormal_tail_pigmentation1.17643942
68MP0009333_abnormal_splenocyte_physiolog1.16185940
69MP0004742_abnormal_vestibular_system1.16019827
70MP0005083_abnormal_biliary_tract1.15712155
71MP0003866_abnormal_defecation1.15335196
72MP0005377_hearing/vestibular/ear_phenot1.14854208
73MP0003878_abnormal_ear_physiology1.14854208
74MP0001800_abnormal_humoral_immune1.13555279
75MP0003172_abnormal_lysosome_physiology1.11677197
76MP0002736_abnormal_nociception_after1.10381025
77MP0002139_abnormal_hepatobiliary_system1.10302264
78MP0008469_abnormal_protein_level1.10296384
79MP0005410_abnormal_fertilization1.08989668
80MP0001533_abnormal_skeleton_physiology1.08320050
81MP0002723_abnormal_immune_serum1.07929826
82MP0001764_abnormal_homeostasis1.07103122
83MP0000015_abnormal_ear_pigmentation1.06185047
84MP0005535_abnormal_body_temperature1.05520155
85MP0001986_abnormal_taste_sensitivity1.05462506
86MP0002277_abnormal_respiratory_mucosa1.05434622
87MP0005164_abnormal_response_to1.04552499
88MP0005332_abnormal_amino_acid1.04330311
89MP0009643_abnormal_urine_homeostasis1.03900919
90MP0005085_abnormal_gallbladder_physiolo1.03208445
91MP0001501_abnormal_sleep_pattern1.01972111
92MP0002272_abnormal_nervous_system1.01113568
93MP0001968_abnormal_touch/_nociception1.00282963
94MP0001727_abnormal_embryo_implantation0.99047950
95MP0004147_increased_porphyrin_level0.98143410
96MP0004858_abnormal_nervous_system0.95227748
97MP0001851_eye_inflammation0.94758363
98MP0001440_abnormal_grooming_behavior0.94526794
99MP0000538_abnormal_urinary_bladder0.93824037
100MP0000343_altered_response_to0.93271449
101MP0000685_abnormal_immune_system0.92581232
102MP0001346_abnormal_lacrimal_gland0.92123164
103MP0005319_abnormal_enzyme/_coenzyme0.92092501
104MP0001663_abnormal_digestive_system0.91934871
105MP0001845_abnormal_inflammatory_respons0.91594126
106MP0002405_respiratory_system_inflammati0.90147873
107MP0003656_abnormal_erythrocyte_physiolo0.89282223
108MP0005075_abnormal_melanosome_morpholog0.88095520
109MP0002452_abnormal_antigen_presenting0.88080770
110MP0002229_neurodegeneration0.86387530
111MP0003634_abnormal_glial_cell0.86094978
112MP0002090_abnormal_vision0.85962502
113MP0004019_abnormal_vitamin_homeostasis0.85129904
114MP0002909_abnormal_adrenal_gland0.84844247
115MP0005584_abnormal_enzyme/coenzyme_acti0.84556157
116MP0003879_abnormal_hair_cell0.84392166
117MP0005464_abnormal_platelet_physiology0.84376458
118MP0001853_heart_inflammation0.82560980
119MP0003075_altered_response_to0.81479153
120MP0002138_abnormal_hepatobiliary_system0.81351880
121MP0001970_abnormal_pain_threshold0.81198186
122MP0005645_abnormal_hypothalamus_physiol0.80361059
123MP0001984_abnormal_olfaction0.80204363
124MP0005360_urolithiasis0.80042658
125MP0001819_abnormal_immune_cell0.79887767
126MP0002064_seizures0.79294653
127MP0002420_abnormal_adaptive_immunity0.79071097
128MP0002822_catalepsy0.78893910
129MP0003638_abnormal_response/metabolism_0.78792589
130MP0000358_abnormal_cell_content/0.78759937
131MP0005165_increased_susceptibility_to0.77932530
132MP0005551_abnormal_eye_electrophysiolog0.77932126
133MP0002095_abnormal_skin_pigmentation0.77904928
134MP0009765_abnormal_xenobiotic_induced0.77716374
135MP0009763_increased_sensitivity_to0.76195777
136MP0003183_abnormal_peptide_metabolism0.76149783
137MP0002118_abnormal_lipid_homeostasis0.75752179
138MP0002933_joint_inflammation0.74723464
139MP0000230_abnormal_systemic_arterial0.74720804
140MP0002136_abnormal_kidney_physiology0.73366985
141MP0003123_paternal_imprinting0.72125256
142MP0005448_abnormal_energy_balance0.71927318

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.46694558
2Abnormal mitochondria in muscle tissue (HP:0008316)4.83924931
3Mitochondrial inheritance (HP:0001427)4.82572754
4Acute encephalopathy (HP:0006846)4.64566412
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.46380064
6Progressive macrocephaly (HP:0004481)4.41585293
7Hepatocellular necrosis (HP:0001404)4.07506832
8Increased CSF lactate (HP:0002490)3.96815415
9Renal Fanconi syndrome (HP:0001994)3.88006306
10Parakeratosis (HP:0001036)3.87063249
11Hepatic necrosis (HP:0002605)3.82705390
12Increased hepatocellular lipid droplets (HP:0006565)3.66661586
13Congenital ichthyosiform erythroderma (HP:0007431)3.65239997
143-Methylglutaconic aciduria (HP:0003535)3.43816612
15Lipid accumulation in hepatocytes (HP:0006561)3.41771890
16Vacuolated lymphocytes (HP:0001922)3.38896168
17Cerebral edema (HP:0002181)3.30563202
18Leukodystrophy (HP:0002415)3.12906576
19Neurofibrillary tangles (HP:0002185)3.02902296
20Increased serum pyruvate (HP:0003542)2.99080418
21Abnormality of glycolysis (HP:0004366)2.99080418
22Respiratory failure (HP:0002878)2.99040171
23Abnormality of renal resorption (HP:0011038)2.93406076
24Abnormality of glycolipid metabolism (HP:0010969)2.84501667
25Abnormality of liposaccharide metabolism (HP:0010968)2.84501667
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.84501667
27Optic disc pallor (HP:0000543)2.84328971
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81124126
29Increased intramyocellular lipid droplets (HP:0012240)2.73801771
30Abnormality of macrophages (HP:0004311)2.66270509
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62759641
32Lactic acidosis (HP:0003128)2.60484657
33Recurrent abscess formation (HP:0002722)2.53395824
34Testicular atrophy (HP:0000029)2.52864107
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51323599
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51323599
37Type I transferrin isoform profile (HP:0003642)2.50380582
38Increased muscle lipid content (HP:0009058)2.49007597
39Exercise intolerance (HP:0003546)2.48568592
40Axonal loss (HP:0003447)2.45633461
41Eczematoid dermatitis (HP:0000976)2.44659911
42Recurrent bacterial skin infections (HP:0005406)2.43952220
43Increased IgM level (HP:0003496)2.39538793
44Abnormality of urine glucose concentration (HP:0011016)2.39028231
45Glycosuria (HP:0003076)2.39028231
46Exertional dyspnea (HP:0002875)2.38276357
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36789312
48Hepatosplenomegaly (HP:0001433)2.35259914
49Increased serum lactate (HP:0002151)2.31840206
50Hypothermia (HP:0002045)2.26040965
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25916052
52Polyphagia (HP:0002591)2.25449442
53Cerebral hemorrhage (HP:0001342)2.24649887
54Prolonged neonatal jaundice (HP:0006579)2.22522238
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16763567
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15578344
57Neuroendocrine neoplasm (HP:0100634)2.15351989
58Abnormal number of erythroid precursors (HP:0012131)2.15183303
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.07822494
60Pheochromocytoma (HP:0002666)2.05137792
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03424623
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.03424623
63Sensory axonal neuropathy (HP:0003390)2.02853438
64Cerebral palsy (HP:0100021)2.01405030
65Abnormal protein glycosylation (HP:0012346)2.00083974
66Abnormal glycosylation (HP:0012345)2.00083974
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00083974
68Abnormal protein N-linked glycosylation (HP:0012347)2.00083974
69Cerebral inclusion bodies (HP:0100314)2.00024765
70Myositis (HP:0100614)1.99486380
71Lethargy (HP:0001254)1.99331951
72Hyperphosphaturia (HP:0003109)1.97390451
73Chronic obstructive pulmonary disease (HP:0006510)1.96413724
74Obstructive lung disease (HP:0006536)1.96413724
75Systemic lupus erythematosus (HP:0002725)1.96009245
76CNS demyelination (HP:0007305)1.95033860
77Nausea (HP:0002018)1.94183651
78Respiratory difficulties (HP:0002880)1.91467908
79Muscle fiber atrophy (HP:0100295)1.91265674
80Erythroderma (HP:0001019)1.90547113
81Autoamputation (HP:0001218)1.89892658
82Cholecystitis (HP:0001082)1.89504124
83Abnormal gallbladder physiology (HP:0012438)1.89504124
84Recurrent gram-negative bacterial infections (HP:0005420)1.89340567
85X-linked dominant inheritance (HP:0001423)1.88828525
86Generalized aminoaciduria (HP:0002909)1.88102813
87Abnormal respiratory motile cilium physiology (HP:0012261)1.88074115
88Abnormal pupillary function (HP:0007686)1.87595199
89Purpura (HP:0000979)1.86727874
90Renal tubular dysfunction (HP:0000124)1.84599910
91Type 2 muscle fiber atrophy (HP:0003554)1.84304675
92Abnormal respiratory epithelium morphology (HP:0012253)1.83736398
93Abnormal respiratory motile cilium morphology (HP:0005938)1.83736398
94Prolonged partial thromboplastin time (HP:0003645)1.83494021
95Progressive neurologic deterioration (HP:0002344)1.76800434
96Reduced antithrombin III activity (HP:0001976)1.76518533
97Hypokinesia (HP:0002375)1.74670863
98Mesangial abnormality (HP:0001966)1.74305258
99Abnormal ciliary motility (HP:0012262)1.73808706
100Methylmalonic aciduria (HP:0012120)1.72363803
101Spastic paraparesis (HP:0002313)1.72331150
102Abnormality of fatty-acid metabolism (HP:0004359)1.72174118
103Methylmalonic acidemia (HP:0002912)1.70757225
104Nasal polyposis (HP:0100582)1.69473580
105Amniotic constriction ring (HP:0009775)1.68574760
106Abnormality of placental membranes (HP:0011409)1.68574760
107Progressive microcephaly (HP:0000253)1.68488250
108Abnormal urine phosphate concentration (HP:0012599)1.68375010
109Abnormality of the heme biosynthetic pathway (HP:0010472)1.67624555
110Medial flaring of the eyebrow (HP:0010747)1.66190847
111Stomatitis (HP:0010280)1.65451711
112Abnormality of cells of the erythroid lineage (HP:0012130)1.65278553
113Vomiting (HP:0002013)1.63672325
114Cholelithiasis (HP:0001081)1.62555798
115Ragged-red muscle fibers (HP:0003200)1.62115687
116Orchitis (HP:0100796)1.61982988
117Myopathic facies (HP:0002058)1.60464336
118Segmental peripheral demyelination/remyelination (HP:0003481)1.59903759
119Loss of speech (HP:0002371)1.59413682
120Hypergammaglobulinemia (HP:0010702)1.58352160
121Increased cerebral lipofuscin (HP:0011813)1.58018988
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.57427712
123Dicarboxylic aciduria (HP:0003215)1.57427712
124Macrocytic anemia (HP:0001972)1.55290236
125Paralysis (HP:0003470)1.54946434
126Elevated erythrocyte sedimentation rate (HP:0003565)1.54897318
127Cerebral hypomyelination (HP:0006808)1.54623824
128Recurrent skin infections (HP:0001581)1.51850665
129Emotional lability (HP:0000712)1.51814872
130Dysostosis multiplex (HP:0000943)1.49121997
131Petechiae (HP:0000967)1.48068313
132Hypomagnesemia (HP:0002917)1.45869770
133Blindness (HP:0000618)1.44860636
134Patchy hypopigmentation of hair (HP:0011365)1.44776033
135Steatorrhea (HP:0002570)1.43953557
136Abnormality of magnesium homeostasis (HP:0004921)1.42416607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.05860280
2MST43.77353433
3VRK23.70912833
4ARAF3.33103136
5STK393.28454077
6MAP3K122.65171331
7MAP3K112.51823679
8BCR2.35212310
9NME22.32188421
10OXSR12.27803473
11STK162.25586340
12MYLK2.02053229
13GRK71.99398907
14BMPR21.93575915
15MAP3K141.87935770
16NME11.84351860
17LIMK11.78517031
18WNK41.76678128
19EPHB11.73619414
20MAPKAPK51.73046484
21PIM21.70244332
22RIPK41.65921138
23BLK1.62193087
24ERN11.59024320
25LRRK21.48654432
26GRK61.42028069
27EPHB21.41135524
28MAPKAPK31.35734803
29MET1.33801273
30CASK1.33663730
31IRAK31.31566255
32IRAK41.31475628
33TBK11.28464714
34TESK11.27702300
35BRAF1.27626259
36MAP2K21.23907451
37TAOK11.21622361
38BMPR1B1.21061544
39PIK3CG1.19360617
40PKN11.17565198
41GRK51.17206571
42MUSK1.14521275
43CAMK2B1.13401109
44MAP4K11.12266993
45TAOK21.10085721
46LMTK21.09880945
47IKBKB1.08186099
48TXK1.07983523
49ADRBK21.07241188
50IKBKE1.04942373
51CAMK2D1.04006751
52FGR1.03716096
53TESK21.01546267
54TNK21.00491962
55CAMK2G1.00284616
56CSK0.99078249
57MAP2K60.97343332
58EPHA20.96991802
59MAPK150.94833670
60ABL20.90126347
61BCKDK0.89096578
62PINK10.87283009
63MST1R0.86909228
64PRKCE0.86535192
65CSNK1G30.86432444
66MAP3K130.82170233
67DAPK10.82148326
68MAP4K20.80965550
69EPHA30.80199852
70DYRK20.78162619
71FES0.77553505
72KDR0.74747183
73NEK60.74512176
74PRKD20.73846027
75RPS6KA50.72965070
76DAPK30.72676910
77PRKCQ0.69803582
78CDK190.69298620
79VRK10.68761694
80CAMK2A0.67655738
81IRAK10.65298614
82DYRK30.64369378
83PHKG20.64231316
84PHKG10.64231316
85ROCK20.63889928
86PRKCD0.62443472
87MOS0.61036065
88PAK40.56742303
89TRPM70.56733715
90ZAP700.56520230
91ADRBK10.56481320
92SYK0.55896355
93EIF2AK10.55830929
94AKT30.55346653
95ILK0.55195176
96OBSCN0.54937036
97NTRK10.54485585
98EIF2AK30.53881069
99GRK10.52995589
100DAPK20.52805717
101PLK20.52341923
102MAP3K20.52097854
103MAP2K70.52055122
104PRKD10.50953753
105PRKCI0.50061539
106PTK2B0.49653024
107CSNK1G10.49094282
108PDK20.49010161
109LCK0.47716529
110ZAK0.47555791
111AURKA0.46345663
112LYN0.46278053
113TIE10.44789583
114MAP3K30.43966913
115DYRK1B0.43827459
116TNIK0.43494424
117PRKG20.43247924
118PRKACA0.42160854
119SIK20.41336834
120MAP2K10.40215564
121SIK30.39756273
122TYK20.39734433
123MAP3K50.39476818
124TEC0.39424110
125IRAK20.38635387
126MATK0.38493886
127MAP2K30.38445118
128CSNK1A1L0.35697390
129PAK30.35105726
130TAOK30.34492551
131PAK10.33850142
132ERBB30.33706822
133CSNK2A20.33533113
134CDK140.33146733
135TLK10.32911083
136PRKCA0.32439160
137CSNK1G20.29971809
138CSNK2A10.29929416
139MAP3K10.29224979
140BUB10.29182250
141BTK0.27309226

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.31387321
2Parkinsons disease_Homo sapiens_hsa050124.11315160
3Protein export_Homo sapiens_hsa030603.43041104
4Alzheimers disease_Homo sapiens_hsa050103.30457857
5Proteasome_Homo sapiens_hsa030503.13880917
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.86789762
7Huntingtons disease_Homo sapiens_hsa050162.72765001
8Collecting duct acid secretion_Homo sapiens_hsa049662.48596972
9Ribosome_Homo sapiens_hsa030102.46789141
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43996379
11Fatty acid elongation_Homo sapiens_hsa000622.43738142
12Sulfur metabolism_Homo sapiens_hsa009202.29293952
13Steroid biosynthesis_Homo sapiens_hsa001002.16254497
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04451659
15Rheumatoid arthritis_Homo sapiens_hsa053231.94831836
16Histidine metabolism_Homo sapiens_hsa003401.75316821
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75220597
18Graft-versus-host disease_Homo sapiens_hsa053321.69274545
19Vibrio cholerae infection_Homo sapiens_hsa051101.69167353
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47170215
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43873603
22Cardiac muscle contraction_Homo sapiens_hsa042601.43252102
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35873107
24Ether lipid metabolism_Homo sapiens_hsa005651.31952016
25RNA polymerase_Homo sapiens_hsa030201.28323835
26Arachidonic acid metabolism_Homo sapiens_hsa005901.22127569
27Phagosome_Homo sapiens_hsa041451.19469777
28Sphingolipid metabolism_Homo sapiens_hsa006001.17116881
29Glutathione metabolism_Homo sapiens_hsa004801.15149101
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14643282
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13402351
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13302939
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.12925723
34Linoleic acid metabolism_Homo sapiens_hsa005911.11974199
35Allograft rejection_Homo sapiens_hsa053301.10809468
36Galactose metabolism_Homo sapiens_hsa000521.09091875
37Lysosome_Homo sapiens_hsa041421.08417127
38Chemical carcinogenesis_Homo sapiens_hsa052041.04881631
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04347491
40Antigen processing and presentation_Homo sapiens_hsa046121.03937892
41Other glycan degradation_Homo sapiens_hsa005111.03761472
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02715985
43Phenylalanine metabolism_Homo sapiens_hsa003601.01807911
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00829595
45Primary immunodeficiency_Homo sapiens_hsa053401.00760902
46Folate biosynthesis_Homo sapiens_hsa007901.00004532
47Peroxisome_Homo sapiens_hsa041460.98109845
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.97677746
49Autoimmune thyroid disease_Homo sapiens_hsa053200.95232501
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93665468
51Regulation of autophagy_Homo sapiens_hsa041400.93389369
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91047183
53Tyrosine metabolism_Homo sapiens_hsa003500.89286207
54Asthma_Homo sapiens_hsa053100.88000643
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.87615772
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87339580
57Staphylococcus aureus infection_Homo sapiens_hsa051500.81274608
58Metabolic pathways_Homo sapiens_hsa011000.80667795
59Type I diabetes mellitus_Homo sapiens_hsa049400.78208402
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.75865787
61Pertussis_Homo sapiens_hsa051330.74571177
62Shigellosis_Homo sapiens_hsa051310.73496109
63Butanoate metabolism_Homo sapiens_hsa006500.71718848
64Pyruvate metabolism_Homo sapiens_hsa006200.70239347
65Propanoate metabolism_Homo sapiens_hsa006400.69798286
66Mineral absorption_Homo sapiens_hsa049780.69122141
67Carbon metabolism_Homo sapiens_hsa012000.68926870
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68010491
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67430514
70Arginine and proline metabolism_Homo sapiens_hsa003300.65098586
71Legionellosis_Homo sapiens_hsa051340.63623277
72Malaria_Homo sapiens_hsa051440.61807867
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61221486
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57778800
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56798011
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55414487
77Salmonella infection_Homo sapiens_hsa051320.55035937
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.54873235
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53853626
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53835458
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51988217
82Synaptic vesicle cycle_Homo sapiens_hsa047210.51987348
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51760553
84Biosynthesis of amino acids_Homo sapiens_hsa012300.51622849
85Retinol metabolism_Homo sapiens_hsa008300.51531589
86Base excision repair_Homo sapiens_hsa034100.50885134
87African trypanosomiasis_Homo sapiens_hsa051430.50872261
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48872517
89Phototransduction_Homo sapiens_hsa047440.47589047
90beta-Alanine metabolism_Homo sapiens_hsa004100.46771176
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45820001
92Vitamin digestion and absorption_Homo sapiens_hsa049770.45548866
93Serotonergic synapse_Homo sapiens_hsa047260.43614242
94Fatty acid degradation_Homo sapiens_hsa000710.41544185
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41483796
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39243285
97Leishmaniasis_Homo sapiens_hsa051400.37952802
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37897434
99Prion diseases_Homo sapiens_hsa050200.36772891
100Pentose phosphate pathway_Homo sapiens_hsa000300.33387732
101Complement and coagulation cascades_Homo sapiens_hsa046100.31900882
102N-Glycan biosynthesis_Homo sapiens_hsa005100.31649520
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31155682
104Fat digestion and absorption_Homo sapiens_hsa049750.30880723
105Sulfur relay system_Homo sapiens_hsa041220.30391052
106Pyrimidine metabolism_Homo sapiens_hsa002400.30030765
107Viral myocarditis_Homo sapiens_hsa054160.29961338
108PPAR signaling pathway_Homo sapiens_hsa033200.29897444
109Tuberculosis_Homo sapiens_hsa051520.28513615
110Tryptophan metabolism_Homo sapiens_hsa003800.27592415
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27389871
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27115236
113Fructose and mannose metabolism_Homo sapiens_hsa000510.24252321
114Hematopoietic cell lineage_Homo sapiens_hsa046400.23053712
115Purine metabolism_Homo sapiens_hsa002300.22899350
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22734419
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.21130369
118Fatty acid metabolism_Homo sapiens_hsa012120.18232807
119Caffeine metabolism_Homo sapiens_hsa002320.16432617

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