CHMP4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)3.87974181
2protein localization to endosome (GO:0036010)3.70623726
3sodium ion export (GO:0071436)3.63943371
4negative regulation of erythrocyte differentiation (GO:0045647)3.60449647
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.52967683
6negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.50212181
7lipopolysaccharide-mediated signaling pathway (GO:0031663)3.41991382
8activation of MAPKKK activity (GO:0000185)3.38900868
9NIK/NF-kappaB signaling (GO:0038061)3.35175885
10cytidine deamination (GO:0009972)3.28396207
11cytidine metabolic process (GO:0046087)3.28396207
12cytidine catabolic process (GO:0006216)3.28396207
13barbed-end actin filament capping (GO:0051016)3.27205108
14regulation of vitamin D biosynthetic process (GO:0060556)3.24581903
15macrophage activation involved in immune response (GO:0002281)3.21608109
16epithelial cell-cell adhesion (GO:0090136)3.15900552
17negative regulation of interleukin-12 production (GO:0032695)3.13340283
18negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.11669855
19positive regulation of Cdc42 GTPase activity (GO:0043089)3.11169696
20modulation by symbiont of host cellular process (GO:0044068)3.09096397
21germinal center formation (GO:0002467)3.07211413
22chondrocyte proliferation (GO:0035988)3.05843216
23regulation of podosome assembly (GO:0071801)3.02365450
24glycosphingolipid catabolic process (GO:0046479)2.99707017
25plasma membrane repair (GO:0001778)2.98703804
26myeloid dendritic cell differentiation (GO:0043011)2.98531270
27response to muramyl dipeptide (GO:0032495)2.92997854
28adhesion of symbiont to host cell (GO:0044650)2.92873204
29virion attachment to host cell (GO:0019062)2.92873204
30regulation of early endosome to late endosome transport (GO:2000641)2.91322696
31regulation of p38MAPK cascade (GO:1900744)2.88951061
32pyrimidine ribonucleoside catabolic process (GO:0046133)2.86581575
33apoptotic cell clearance (GO:0043277)2.85485299
34regulation of T-helper 2 cell differentiation (GO:0045628)2.84881065
35cellular response to thyroid hormone stimulus (GO:0097067)2.76904770
36adhesion of symbiont to host (GO:0044406)2.76473920
37cellular potassium ion homeostasis (GO:0030007)2.75062372
38mannose metabolic process (GO:0006013)2.72255885
39stress fiber assembly (GO:0043149)2.69753759
40low-density lipoprotein particle clearance (GO:0034383)2.69495474
41growth hormone receptor signaling pathway (GO:0060396)2.69176555
42positive regulation of p38MAPK cascade (GO:1900745)2.68827466
43layer formation in cerebral cortex (GO:0021819)2.68558429
44bone resorption (GO:0045453)2.67345649
45glycolipid catabolic process (GO:0019377)2.67301286
46positive regulation of cellular amide metabolic process (GO:0034250)2.66624398
47regulation of vitamin metabolic process (GO:0030656)2.62865025
48T-helper 1 type immune response (GO:0042088)2.62228496
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61764165
50positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59042802
51pinocytosis (GO:0006907)2.57543920
52neutrophil activation involved in immune response (GO:0002283)2.56820405
53negative regulation of cytokine production involved in immune response (GO:0002719)2.55432950
54cellular response to type I interferon (GO:0071357)2.55211552
55type I interferon signaling pathway (GO:0060337)2.55211552
56regulation of extracellular matrix disassembly (GO:0010715)2.55193542
57regulation of cholesterol homeostasis (GO:2000188)2.54725201
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54600747
59cortical actin cytoskeleton organization (GO:0030866)2.53298589
60detection of other organism (GO:0098543)2.52993777
61positive regulation of extracellular matrix organization (GO:1903055)2.52920336
62response to type I interferon (GO:0034340)2.52898492
63regulation of clathrin-mediated endocytosis (GO:2000369)2.52656093
64positive regulation of histone deacetylation (GO:0031065)2.52497721
65negative regulation of fatty acid transport (GO:2000192)2.52391682
66positive regulation of chemokine biosynthetic process (GO:0045080)2.51222466
67regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51131314
68regulation of ARF GTPase activity (GO:0032312)2.48029221
69negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45466845
70immunoglobulin mediated immune response (GO:0016064)2.44689784
71detection of bacterium (GO:0016045)2.43903545
72regulation of leukocyte degranulation (GO:0043300)2.42679137
73positive regulation of gamma-delta T cell activation (GO:0046645)2.41746777
74oligosaccharide catabolic process (GO:0009313)2.41518165
75interferon-gamma-mediated signaling pathway (GO:0060333)2.41481724
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38474395
77cellular response to virus (GO:0098586)2.37522389
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.37250414
79regulation of glucose import in response to insulin stimulus (GO:2001273)2.36718438
80regulation of necrotic cell death (GO:0010939)2.36467540
81peptide catabolic process (GO:0043171)2.36248204
82myeloid dendritic cell activation (GO:0001773)2.35812984
83cellular response to growth hormone stimulus (GO:0071378)2.35350526
84regulation of membrane protein ectodomain proteolysis (GO:0051043)2.34981163
85semaphorin-plexin signaling pathway (GO:0071526)2.34695689
86negative regulation of cell killing (GO:0031342)2.34286651
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34286651
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34023590
89regulation of T-helper 1 cell differentiation (GO:0045625)2.33504436
90regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.33328444
91cell adhesion mediated by integrin (GO:0033627)2.33118898
92activation of protein kinase A activity (GO:0034199)2.33060542
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.32980143
94regulation of mononuclear cell migration (GO:0071675)2.32770837
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.31084920
96regulation of cytokine secretion involved in immune response (GO:0002739)2.30936421
97response to thyroid hormone (GO:0097066)2.30077154
98regulation of interferon-beta biosynthetic process (GO:0045357)2.29374667
99modulation by virus of host process (GO:0019054)2.29345493
100synaptic vesicle maturation (GO:0016188)2.29066991
101regulation of type 2 immune response (GO:0002828)2.28933654
102adherens junction assembly (GO:0034333)2.28899785
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.28443182
104heterochromatin organization (GO:0070828)2.27500672
105positive regulation of type 2 immune response (GO:0002830)2.27240685
106detection of molecule of bacterial origin (GO:0032490)2.27108739
107positive regulation of macrophage cytokine production (GO:0060907)2.26223008
108cell-substrate junction assembly (GO:0007044)2.25609277
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25290276
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25290276
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.25105060
112regulation of chemokine biosynthetic process (GO:0045073)2.24986776
113regulation of necroptotic process (GO:0060544)2.24795689
114regulation of superoxide anion generation (GO:0032928)2.24367711
115receptor catabolic process (GO:0032801)2.23768496
116detection of external biotic stimulus (GO:0098581)2.23697072
117potassium ion import (GO:0010107)2.23671511
118regulation of ARF protein signal transduction (GO:0032012)2.22883157
119hemidesmosome assembly (GO:0031581)2.22410887
120regulation of NFAT protein import into nucleus (GO:0051532)2.21958403
121endocytic recycling (GO:0032456)2.21668077
122positive regulation of protein dephosphorylation (GO:0035307)2.21251824
123regulation of extracellular matrix organization (GO:1903053)2.20685446
124cellular response to nerve growth factor stimulus (GO:1990090)2.20644013
125response to nerve growth factor (GO:1990089)2.20644013
126regulation of cholesterol storage (GO:0010885)2.20188404
127activation of JUN kinase activity (GO:0007257)2.19334364
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.17980140
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.17257096
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17194868
131skin morphogenesis (GO:0043589)2.16799542
132protein retention in ER lumen (GO:0006621)2.16454838
133negative regulation of cell size (GO:0045792)2.16259865
134dendritic cell differentiation (GO:0097028)2.15308755
135positive regulation of receptor recycling (GO:0001921)2.15213986
136response to protozoan (GO:0001562)2.14261344
137response to laminar fluid shear stress (GO:0034616)2.13440621
138locomotory exploration behavior (GO:0035641)2.12727024
139extracellular matrix assembly (GO:0085029)2.12550789
140establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.12515774
141negative regulation of potassium ion transmembrane transport (GO:1901380)2.12193334
142nerve growth factor signaling pathway (GO:0038180)2.11729449
143macroautophagy (GO:0016236)2.11040323
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.10992232
145cortical cytoskeleton organization (GO:0030865)2.07929574
146regulation of macrophage cytokine production (GO:0010935)2.06007671
147positive regulation of protein export from nucleus (GO:0046827)2.04639057
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.03327801
149cell communication by electrical coupling (GO:0010644)2.02997122
150cellular sodium ion homeostasis (GO:0006883)2.01985403
151alkaloid metabolic process (GO:0009820)2.01217193
152cell communication involved in cardiac conduction (GO:0086065)2.00664671
153negative regulation of T cell differentiation in thymus (GO:0033085)2.00017450
154negative regulation of cardiac muscle tissue growth (GO:0055022)1.98483920
155negative regulation of heart growth (GO:0061117)1.98483920
156positive regulation of JUN kinase activity (GO:0043507)1.97001001
157signal complex assembly (GO:0007172)1.96545654
158negative regulation of smooth muscle cell migration (GO:0014912)1.96290271
159sexual reproduction (GO:0019953)1.96041156
160positive regulation by symbiont of host defense response (GO:0052509)1.95944019
161modulation by symbiont of host defense response (GO:0052031)1.95944019
162modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.95944019
163modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.95944019
164positive regulation by organism of defense response of other organism involved in symbiotic interact1.95944019
165modulation by symbiont of host immune response (GO:0052553)1.95944019
166antigen processing and presentation of endogenous antigen (GO:0019883)1.93340416
167cell-substrate adherens junction assembly (GO:0007045)1.90273345
168focal adhesion assembly (GO:0048041)1.90273345
169positive regulation of nitric-oxide synthase activity (GO:0051000)1.90098865
170positive regulation of nuclease activity (GO:0032075)1.89930520
171maternal placenta development (GO:0001893)1.88586785
172blood vessel endothelial cell migration (GO:0043534)1.85922017
173negative regulation of nucleotide catabolic process (GO:0030812)1.85672700
174positive regulation of lamellipodium assembly (GO:0010592)1.84873071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.94481164
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04988799
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46658265
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.31141552
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10040019
6KDM2B_26808549_Chip-Seq_DND41_Human2.08820628
7CLOCK_20551151_ChIP-Seq_293T_Human2.01224355
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00579806
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94463350
10LXR_22292898_ChIP-Seq_THP-1_Human1.93991518
11BP1_19119308_ChIP-ChIP_Hs578T_Human1.90047046
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89621637
13IRF8_22096565_ChIP-ChIP_GC-B_Human1.89555697
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85021514
15RACK7_27058665_Chip-Seq_MCF-7_Human1.82690275
16KDM2B_26808549_Chip-Seq_K562_Human1.82504327
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.81081463
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77507590
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74544308
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.71673088
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68897771
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66237859
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63970357
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63387901
25TCF7_22412390_ChIP-Seq_EML_Mouse1.63248193
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60701950
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.59532224
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.58755656
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58375880
30* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58306421
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54610721
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54569647
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.49835697
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48374106
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47956536
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47192962
37ZNF263_19887448_ChIP-Seq_K562_Human1.46099189
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44984130
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44802316
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.44376156
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42972683
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41340608
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40402035
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39922686
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.36400463
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34255970
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33959544
48VDR_21846776_ChIP-Seq_THP-1_Human1.33852091
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33064450
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32485833
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31588054
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.30373230
53ATF3_27146783_Chip-Seq_COLON_Human1.29834501
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29457072
55* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29226156
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29006740
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26690974
58GATA1_19941826_ChIP-Seq_K562_Human1.26517968
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.25850229
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25295669
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25277604
62DROSHA_22980978_ChIP-Seq_HELA_Human1.23770169
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23063235
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.23020175
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22746315
66MAF_26560356_Chip-Seq_TH1_Human1.21724736
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21592922
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21343786
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20508345
70MYC_22102868_ChIP-Seq_BL_Human1.18935336
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18782508
72CREB1_26743006_Chip-Seq_LNCaP_Human1.18683445
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18438598
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18249715
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17940576
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17612356
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16117902
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.15826524
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14739230
80SMC4_20622854_ChIP-Seq_HELA_Human1.14319285
81* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13325512
82* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12802601
83RXR_22108803_ChIP-Seq_LS180_Human1.12457306
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12430347
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.12427090
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12389956
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09703383
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.09676173
89* TET1_21451524_ChIP-Seq_MESCs_Mouse1.09395693
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08957608
91* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08863981
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08539325
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07999409
94VDR_24763502_ChIP-Seq_THP-1_Human1.07777225
95MAF_26560356_Chip-Seq_TH2_Human1.07753388
96KLF5_25053715_ChIP-Seq_YYC3_Human1.07113623
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.07108672
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05377673
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05138655
100* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05006924
101EGR1_19032775_ChIP-ChIP_M12_Human1.04927001
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03971015
103* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03440345
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03423761
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02567533
106SPI1_23127762_ChIP-Seq_K562_Human1.02279180
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02088572
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.01389028
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.01389028
110* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01358485
111TP63_22573176_ChIP-Seq_HFKS_Human1.00914653
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00075283
113* NCOR1_26117541_ChIP-Seq_K562_Human0.99991015
114RXR_22158963_ChIP-Seq_LIVER_Mouse0.99846227
115MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99416357
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99042336
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98799366
118P68_20966046_ChIP-Seq_HELA_Human0.97668793
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97512130
120GATA2_19941826_ChIP-Seq_K562_Human0.97386816
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97363628
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96910142
123* SOX2_20726797_ChIP-Seq_SW620_Human0.96238722
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.95866976
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95692171
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95616529
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95327454
128UTX_26944678_Chip-Seq_JUKART_Human0.92630991
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92046334
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.91986105
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.91982846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.23152808
2MP0003283_abnormal_digestive_organ4.82903969
3MP0003705_abnormal_hypodermis_morpholog3.96928477
4MP0003566_abnormal_cell_adhesion3.17289359
5MP0003303_peritoneal_inflammation3.06511772
6MP0005451_abnormal_body_composition2.84927417
7MP0003300_gastrointestinal_ulcer2.84007258
8MP0002234_abnormal_pharynx_morphology2.45296821
9MP0005058_abnormal_lysosome_morphology2.34585731
10MP0004510_myositis2.25189894
11MP0002148_abnormal_hypersensitivity_rea2.14590822
12MP0003045_fibrosis2.12543526
13MP0003724_increased_susceptibility_to2.01828568
14MP0008438_abnormal_cutaneous_collagen1.97124544
15MP0004185_abnormal_adipocyte_glucose1.96248960
16MP0004859_abnormal_synaptic_plasticity1.95836990
17MP0009053_abnormal_anal_canal1.93966189
18MP0009785_altered_susceptibility_to1.93818516
19MP0002139_abnormal_hepatobiliary_system1.92091460
20MP0004858_abnormal_nervous_system1.91164313
21MP0002419_abnormal_innate_immunity1.90059048
22MP0005025_abnormal_response_to1.88147769
23MP0005000_abnormal_immune_tolerance1.83885672
24MP0005275_abnormal_skin_tensile1.79593551
25MP0008961_abnormal_basal_metabolism1.78702530
26MP0004947_skin_inflammation1.75100400
27MP0000858_altered_metastatic_potential1.75016629
28MP0001835_abnormal_antigen_presentation1.74389235
29MP0005623_abnormal_meninges_morphology1.69991486
30MP0008260_abnormal_autophagy1.64935838
31MP0003329_amyloid_beta_deposits1.64127533
32MP0002877_abnormal_melanocyte_morpholog1.58338336
33MP0000604_amyloidosis1.57478247
34MP0008004_abnormal_stomach_pH1.56635374
35MP0002796_impaired_skin_barrier1.54684346
36MP0005076_abnormal_cell_differentiation1.54322223
37MP0005167_abnormal_blood-brain_barrier1.51432229
38MP0003075_altered_response_to1.47592511
39MP0004130_abnormal_muscle_cell1.46816043
40MP0002452_abnormal_antigen_presenting1.41314267
41MP0004272_abnormal_basement_membrane1.38521860
42MP0002723_abnormal_immune_serum1.36947153
43MP0003091_abnormal_cell_migration1.36569894
44MP0003183_abnormal_peptide_metabolism1.33706080
45MP0001853_heart_inflammation1.33428980
46MP0003453_abnormal_keratinocyte_physiol1.32317328
47MP0009840_abnormal_foam_cell1.32109767
48MP0010352_gastrointestinal_tract_polyps1.31978701
49MP0001800_abnormal_humoral_immune1.30070316
50MP0001958_emphysema1.29482762
51MP0003172_abnormal_lysosome_physiology1.29431144
52MP0001845_abnormal_inflammatory_respons1.25471784
53MP0010678_abnormal_skin_adnexa1.20836284
54MP0002909_abnormal_adrenal_gland1.20629659
55MP0001819_abnormal_immune_cell1.20278088
56MP0000751_myopathy1.19968628
57MP0002420_abnormal_adaptive_immunity1.19947711
58MP0009333_abnormal_splenocyte_physiolog1.19460771
59MP0009764_decreased_sensitivity_to1.15865704
60MP0001849_ear_inflammation1.15259586
61MP0009780_abnormal_chondrocyte_physiolo1.14832093
62MP0005666_abnormal_adipose_tissue1.13733089
63MP0005671_abnormal_response_to1.13598101
64MP0008469_abnormal_protein_level1.09281525
65MP0003436_decreased_susceptibility_to1.08768369
66MP0003191_abnormal_cellular_cholesterol1.08271119
67MP0000569_abnormal_digit_pigmentation1.08190883
68MP0002896_abnormal_bone_mineralization1.06196663
69MP0002405_respiratory_system_inflammati1.05582521
70MP0000733_abnormal_muscle_development1.05387828
71MP0005409_darkened_coat_color1.04220768
72MP0005375_adipose_tissue_phenotype1.03539509
73MP0001666_abnormal_nutrient_absorption1.01114821
74MP0004264_abnormal_extraembryonic_tissu1.00690635
75MP0005166_decreased_susceptibility_to0.99935331
76MP0005165_increased_susceptibility_to0.99670664
77MP0004087_abnormal_muscle_fiber0.98878011
78MP0003828_pulmonary_edema0.97359140
79MP0005083_abnormal_biliary_tract0.96217772
80MP0003690_abnormal_glial_cell0.96199235
81MP0003866_abnormal_defecation0.95956042
82MP0000920_abnormal_myelination0.94602330
83MP0005023_abnormal_wound_healing0.94286853
84MP0005390_skeleton_phenotype0.91124511
85MP0002089_abnormal_postnatal_growth/wei0.90864120
86MP0003879_abnormal_hair_cell0.90389501
87MP0003279_aneurysm0.90372599
88MP0002254_reproductive_system_inflammat0.89688939
89MP0002998_abnormal_bone_remodeling0.88985051
90MP0003634_abnormal_glial_cell0.87593931
91MP0001545_abnormal_hematopoietic_system0.87319402
92MP0005397_hematopoietic_system_phenotyp0.87319402
93MP0009278_abnormal_bone_marrow0.86942158
94MP0001663_abnormal_digestive_system0.86091791
95MP0000747_muscle_weakness0.85904730
96MP0001501_abnormal_sleep_pattern0.85630710
97MP0001765_abnormal_ion_homeostasis0.84827422
98MP0000716_abnormal_immune_system0.84306424
99MP0006082_CNS_inflammation0.84185299
100MP0000678_abnormal_parathyroid_gland0.84161323
101MP0003656_abnormal_erythrocyte_physiolo0.83524889
102MP0005310_abnormal_salivary_gland0.81964554
103MP0000490_abnormal_crypts_of0.81390474
104MP0005164_abnormal_response_to0.80995118
105MP0001756_abnormal_urination0.80412440
106MP0001348_abnormal_lacrimal_gland0.79732451
107MP0004084_abnormal_cardiac_muscle0.79350044
108MP0008569_lethality_at_weaning0.79205919
109MP0003448_altered_tumor_morphology0.79059872
110MP0001533_abnormal_skeleton_physiology0.78620512
111MP0002332_abnormal_exercise_endurance0.75739921
112MP0000013_abnormal_adipose_tissue0.74847980
113MP0000462_abnormal_digestive_system0.72718094
114MP0001542_abnormal_bone_strength0.72587312
115MP0003763_abnormal_thymus_physiology0.71039857
116MP0005387_immune_system_phenotype0.70635936
117MP0001790_abnormal_immune_system0.70635936
118MP0002398_abnormal_bone_marrow0.69050624
119MP0001881_abnormal_mammary_gland0.68954550
120MP0000750_abnormal_muscle_regeneration0.68945198
121MP0005381_digestive/alimentary_phenotyp0.68554568
122MP0005501_abnormal_skin_physiology0.66505970
123MP0000003_abnormal_adipose_tissue0.65424251
124MP0000534_abnormal_ureter_morphology0.65064694
125MP0000377_abnormal_hair_follicle0.64683230
126MP0002168_other_aberrant_phenotype0.64570741
127MP0000685_abnormal_immune_system0.64455760
128MP0010630_abnormal_cardiac_muscle0.64291279
129MP0003252_abnormal_bile_duct0.63675645
130MP0003795_abnormal_bone_structure0.62354143
131MP0010155_abnormal_intestine_physiology0.61116973
132MP0000343_altered_response_to0.60325529
133MP0000767_abnormal_smooth_muscle0.60296464
134MP0008775_abnormal_heart_ventricle0.60018640
135MP0005464_abnormal_platelet_physiology0.59817898
136MP0003385_abnormal_body_wall0.59345125
137MP0005257_abnormal_intraocular_pressure0.59287823
138MP0001216_abnormal_epidermal_layer0.59208274
139MP0009643_abnormal_urine_homeostasis0.58933642
140MP0002282_abnormal_trachea_morphology0.58281406
141MP0008874_decreased_physiological_sensi0.58179948
142MP0006054_spinal_hemorrhage0.57607779
143MP0002837_dystrophic_cardiac_calcinosis0.57354191
144MP0010329_abnormal_lipoprotein_level0.56351461
145MP0003635_abnormal_synaptic_transmissio0.55965313
146MP0002090_abnormal_vision0.55826379
147MP0001851_eye_inflammation0.53826018
148MP0004036_abnormal_muscle_relaxation0.52422084

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.26078029
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.26078029
3Abnormality of glycolipid metabolism (HP:0010969)4.26078029
4Flat acetabular roof (HP:0003180)4.00828987
5Neonatal short-limb short stature (HP:0008921)3.92179198
6Systemic lupus erythematosus (HP:0002725)3.59493417
7Abnormality of macrophages (HP:0004311)3.31579555
8Abnormality of the distal phalanx of the thumb (HP:0009617)3.13926835
9Nuclear cataract (HP:0100018)3.12866319
10Axonal loss (HP:0003447)3.04303825
11Cerebral aneurysm (HP:0004944)3.02705285
12Loss of speech (HP:0002371)2.91284472
13Spinal cord compression (HP:0002176)2.86939482
14Cupped ribs (HP:0000887)2.73198818
15Large earlobe (HP:0009748)2.73035703
16Disinhibition (HP:0000734)2.68271905
17Abnormal cartilage morphology (HP:0002763)2.65600760
18Visceral angiomatosis (HP:0100761)2.65446292
19Symphalangism affecting the phalanges of the hand (HP:0009773)2.61957263
20Vertebral compression fractures (HP:0002953)2.59218514
21Amyloidosis (HP:0011034)2.58640794
22Recurrent bacterial skin infections (HP:0005406)2.54432557
23Hyperparathyroidism (HP:0000843)2.53631899
24Achilles tendon contracture (HP:0001771)2.50530088
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.49260714
26Hemangiomatosis (HP:0007461)2.47897736
27Abnormality of the 1st metacarpal (HP:0010009)2.46800367
28Recurrent abscess formation (HP:0002722)2.46698786
29Vertebral hypoplasia (HP:0008417)2.45781621
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.45781621
31Vacuolated lymphocytes (HP:0001922)2.43973860
32Apathy (HP:0000741)2.42489724
33Neuronal loss in central nervous system (HP:0002529)2.40485926
34Flattened epiphyses (HP:0003071)2.40412437
35Dysostosis multiplex (HP:0000943)2.40098791
36Increased cerebral lipofuscin (HP:0011813)2.39050923
37Orchitis (HP:0100796)2.38712377
38Vertebral clefting (HP:0008428)2.37080937
39Distal lower limb muscle weakness (HP:0009053)2.36719992
40Hyporeflexia of lower limbs (HP:0002600)2.36650944
41Glomerulonephritis (HP:0000099)2.35910428
42Malnutrition (HP:0004395)2.35119170
43Abnormality of the Achilles tendon (HP:0005109)2.34401311
44Protrusio acetabuli (HP:0003179)2.32012631
45Diminished motivation (HP:0000745)2.31216941
46Upper limb amyotrophy (HP:0009129)2.30601425
47Distal upper limb amyotrophy (HP:0007149)2.30601425
48Coronal craniosynostosis (HP:0004440)2.29223391
49Right ventricular cardiomyopathy (HP:0011663)2.23972652
50Distal lower limb amyotrophy (HP:0008944)2.21957298
51Abnormality of complement system (HP:0005339)2.21864066
52Genu recurvatum (HP:0002816)2.21383279
53Myositis (HP:0100614)2.20656285
54Abnormality of the nasal mucosa (HP:0000433)2.20466660
55Segmental peripheral demyelination/remyelination (HP:0003481)2.19864978
56Cerebral inclusion bodies (HP:0100314)2.18865131
57Breech presentation (HP:0001623)2.17491993
58Shallow orbits (HP:0000586)2.15706825
59Gastrointestinal stroma tumor (HP:0100723)2.15466149
60Abnormal vertebral ossification (HP:0100569)2.15349070
61Mitral valve prolapse (HP:0001634)2.14590979
62Premature rupture of membranes (HP:0001788)2.14532420
63Recurrent gram-negative bacterial infections (HP:0005420)2.14467559
64Fragile nails (HP:0001808)2.13293110
65Increased IgE level (HP:0003212)2.13190666
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12478367
67Mediastinal lymphadenopathy (HP:0100721)2.10282606
68Purpura (HP:0000979)2.09463701
69Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05762679
70Hip contracture (HP:0003273)2.05487732
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.05373712
72Lumbar hyperlordosis (HP:0002938)2.05304495
73Frequent falls (HP:0002359)2.04155725
74Supranuclear gaze palsy (HP:0000605)2.04146311
75Polygenic inheritance (HP:0010982)2.03082642
76Megalencephaly (HP:0001355)2.02955249
77Hemorrhage of the eye (HP:0011885)2.02675366
78Eczematoid dermatitis (HP:0000976)2.02348443
79Obstructive sleep apnea (HP:0002870)2.02337964
80Complement deficiency (HP:0004431)2.01771117
81Bone pain (HP:0002653)2.00475971
82Cellulitis (HP:0100658)1.98520893
83Difficulty running (HP:0009046)1.98120605
84Exercise-induced muscle cramps (HP:0003710)1.97595303
85Mutism (HP:0002300)1.96970511
86Mucopolysacchariduria (HP:0008155)1.96885513
87Urinary glycosaminoglycan excretion (HP:0003541)1.96885513
88Flat capital femoral epiphysis (HP:0003370)1.95460485
89Tracheal stenosis (HP:0002777)1.95311926
90Peritonitis (HP:0002586)1.94902263
91Hyperextensible skin (HP:0000974)1.94372655
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92865576
93Retrobulbar optic neuritis (HP:0100654)1.92803440
94Optic neuritis (HP:0100653)1.92803440
95Gingivitis (HP:0000230)1.91672313
96Ovoid vertebral bodies (HP:0003300)1.91546328
97Increased variability in muscle fiber diameter (HP:0003557)1.90556275
98Increased connective tissue (HP:0009025)1.90407901
99Emphysema (HP:0002097)1.89939585
100Hand muscle atrophy (HP:0009130)1.89364928
101Short phalanx of the thumb (HP:0009660)1.89234043
102Absent phalangeal crease (HP:0006109)1.88412156
103Increased serum ferritin (HP:0003281)1.87810780
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87527231
105Abnormality of polysaccharide metabolism (HP:0011012)1.87527231
106Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87527231
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87362420
108Asymmetric septal hypertrophy (HP:0001670)1.86906899
109Pathologic fracture (HP:0002756)1.86813715
110Broad metatarsal (HP:0001783)1.86569284
111Myocardial infarction (HP:0001658)1.86159961
112Ulnar bowing (HP:0003031)1.85904585
113Nasal polyposis (HP:0100582)1.85497116
114Mildly elevated creatine phosphokinase (HP:0008180)1.85335310
115Upper motor neuron abnormality (HP:0002127)1.81838140
116Type 1 muscle fiber predominance (HP:0003803)1.80802968
117Dilatation of the ascending aorta (HP:0005111)1.79002130
118Deep venous thrombosis (HP:0002625)1.78869180
119Short hallux (HP:0010109)1.78732870
120Exercise-induced myalgia (HP:0003738)1.78346502
121Atrophic scars (HP:0001075)1.76577464
122Dementia (HP:0000726)1.76435273
123Woolly hair (HP:0002224)1.75185505
124Personality changes (HP:0000751)1.74755034
125Interstitial pulmonary disease (HP:0006530)1.74741512
126Thoracic kyphosis (HP:0002942)1.74700380
127Abnormality of carpal bone ossification (HP:0006257)1.74421531
128Abnormality of the 2nd finger (HP:0004100)1.74388486
129Difficulty climbing stairs (HP:0003551)1.74275195
130Short middle phalanx of finger (HP:0005819)1.73714549
131Obstructive lung disease (HP:0006536)1.73560259
132Chronic obstructive pulmonary disease (HP:0006510)1.73560259
133Aneurysm (HP:0002617)1.73388439
134Abnormal ossification of hand bones (HP:0005921)1.72561549
135Abnormality of the middle phalanges of the toes (HP:0010183)1.72496127
136Abnormality of skeletal muscle fiber size (HP:0012084)1.71530755
137Hypercortisolism (HP:0001578)1.70483157
138Vasculitis (HP:0002633)1.70426926
139Rapidly progressive (HP:0003678)1.68156416
140Aortic aneurysm (HP:0004942)1.67977128
141Abnormality of the thoracic spine (HP:0100711)1.67707500
142Broad face (HP:0000283)1.67664951
143Ulnar deviation of finger (HP:0009465)1.67566597
144Intellectual disability, profound (HP:0002187)1.66699229
145Abnormality of the proximal phalanges of the hand (HP:0009834)1.66662087
146Neurofibrillary tangles (HP:0002185)1.66353781
147Thin bony cortex (HP:0002753)1.66132418
148Progressive neurologic deterioration (HP:0002344)1.65808733
149Asymmetric growth (HP:0100555)1.65291997
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.65223756
151Increased density of long bones (HP:0006392)1.65018688
152Restrictive lung disease (HP:0002091)1.64653169
153Broad palm (HP:0001169)1.64503634
154Hyperacusis (HP:0010780)1.64039743
155Aortic dissection (HP:0002647)1.63221630
156Bulbar palsy (HP:0001283)1.62850397
157Subacute progressive viral hepatitis (HP:0006572)1.62306235
158Striae distensae (HP:0001065)1.62248506
159Turricephaly (HP:0000262)1.60438644
160Hip dysplasia (HP:0001385)1.60433157
161Scapular winging (HP:0003691)1.60395767
162Abnormality of the acetabulum (HP:0003170)1.59897088
163Increased CSF protein (HP:0002922)1.59084036
164Slow saccadic eye movements (HP:0000514)1.57116920
165Urticaria (HP:0001025)1.56384742
166Spontaneous hematomas (HP:0007420)1.56024270
167Multiple lipomas (HP:0001012)1.55217985
168Lower limb amyotrophy (HP:0007210)1.54978402
169Mitral regurgitation (HP:0001653)1.54883827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK38.56922887
2TRIB33.94127593
3IRAK33.65378142
4PRPF4B3.42988990
5EPHB22.97288918
6RIPK12.92238494
7PKN22.72825231
8MAP3K92.51609129
9KSR22.45888258
10NME22.39584961
11TAOK22.05661304
12TTN1.89333504
13PTK61.87768365
14ERN11.76336522
15EEF2K1.76178603
16SMG11.76012082
17TAOK11.73013924
18EPHB11.70112476
19MAP3K31.65625493
20EPHA21.62382133
21ICK1.59807573
22MAP2K31.57669654
23BMX1.50274974
24IRAK41.49020420
25MAP3K21.47532865
26CDC42BPA1.40540022
27PDGFRA1.27843413
28MAP3K101.27552174
29MAP3K131.25305847
30RIPK41.24043411
31ALK1.23308783
32DDR21.22616865
33BLK1.16356885
34LRRK21.11774713
35GRK61.10592718
36RET1.10001385
37PTK21.09107126
38ZAP701.07738063
39CAMKK11.03983681
40DMPK1.03166847
41ILK1.01742639
42TGFBR20.98023064
43MATK0.97229776
44PAK60.96827023
45IRAK20.94218520
46FGFR40.92202933
47PRKD30.91108870
48MAP3K10.90429482
49LMTK20.90221172
50TYRO30.89801656
51NTRK10.86196859
52CAMK1G0.85316941
53SIK10.82106025
54PIM20.81639012
55PTK2B0.80319812
56SIK30.80069265
57ARAF0.77765098
58JAK10.75344647
59PAK40.74908960
60GRK70.74347318
61PRKCH0.74327519
62TBK10.73477989
63SCYL20.73254159
64IKBKE0.73178140
65TESK20.72995313
66SIK20.72970383
67FER0.71848382
68FGR0.71356324
69MAP2K20.70866688
70JAK30.70033464
71PDGFRB0.67637591
72MAP2K10.67124458
73JAK20.65846735
74CSK0.65659080
75IKBKB0.64150559
76ABL20.64119872
77PDPK10.63923609
78HIPK20.61493865
79RPS6KA20.61413459
80DAPK20.61172253
81PRKG20.60394649
82MAP3K70.59990039
83FGFR30.58800845
84MST1R0.57968062
85PDK10.56349555
86MAP4K10.55835570
87MOS0.55707069
88LATS20.53909541
89STK110.53467406
90MAP3K140.53237395
91RPS6KC10.53138892
92RPS6KL10.53138892
93FES0.53070624
94BRAF0.52371299
95PAK30.51634589
96CAMK1D0.51407479
97PRKD10.51027080
98MAPK120.50596936
99CHUK0.49324043
100CSF1R0.48790851
101PAK20.48770732
102KSR10.47330164
103FGFR10.47173431
104STK380.47046333
105MTOR0.46936043
106DYRK1B0.46789036
107MAPK70.46575923
108TYK20.46285985
109SGK30.45808034
110STK240.45420207
111NEK90.45319084
112PHKG10.44265075
113PHKG20.44265075
114TESK10.43995221
115SRC0.43266208
116STK100.43126981
117MAPK110.42296953
118CDK60.42073640
119EPHA30.41058047
120DAPK30.40656566
121HCK0.40643967
122MAP3K60.40034295
123IRAK10.38290278
124PRKD20.38281118
125EGFR0.37283485
126ROCK20.36126123
127MAP3K80.35971692
128NTRK30.35658893
129ITK0.35487752
130WNK10.34646700
131CDK50.33384177
132FYN0.30280411
133RAF10.30258879
134MINK10.28563284
135MARK20.27668903
136RPS6KA10.27531590
137MAP3K110.27366772
138CDK120.26709102
139GSK3A0.26635475

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.83013584
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.61296308
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.08050610
4Nitrogen metabolism_Homo sapiens_hsa009102.00985948
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.73270348
6Chronic myeloid leukemia_Homo sapiens_hsa052201.60461435
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.52735858
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44959329
9Malaria_Homo sapiens_hsa051441.44344347
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.43891748
11VEGF signaling pathway_Homo sapiens_hsa043701.39542178
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35252816
13Type II diabetes mellitus_Homo sapiens_hsa049301.31688027
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28915485
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27757970
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27184512
17Influenza A_Homo sapiens_hsa051641.26468416
18Glioma_Homo sapiens_hsa052141.25877414
19Osteoclast differentiation_Homo sapiens_hsa043801.24888611
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24441920
21Estrogen signaling pathway_Homo sapiens_hsa049151.23470128
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23128296
23Amoebiasis_Homo sapiens_hsa051461.22260046
24Rheumatoid arthritis_Homo sapiens_hsa053231.21163544
25Dorso-ventral axis formation_Homo sapiens_hsa043201.20497297
26Bile secretion_Homo sapiens_hsa049761.20187543
27Allograft rejection_Homo sapiens_hsa053301.20056365
28Proteoglycans in cancer_Homo sapiens_hsa052051.14422198
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.12673295
30Focal adhesion_Homo sapiens_hsa045101.12270014
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09718369
32Endometrial cancer_Homo sapiens_hsa052131.09327348
33Gastric acid secretion_Homo sapiens_hsa049711.08152406
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07981006
35Salivary secretion_Homo sapiens_hsa049701.07631425
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06027926
37Notch signaling pathway_Homo sapiens_hsa043301.04930541
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.04837026
39Renal cell carcinoma_Homo sapiens_hsa052111.04467850
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04178573
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03952122
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.03541948
43Legionellosis_Homo sapiens_hsa051341.02956041
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02795406
45African trypanosomiasis_Homo sapiens_hsa051431.02744704
46mTOR signaling pathway_Homo sapiens_hsa041501.02086865
47B cell receptor signaling pathway_Homo sapiens_hsa046621.01206188
48Mineral absorption_Homo sapiens_hsa049780.99513526
49Pancreatic cancer_Homo sapiens_hsa052120.99057397
50Graft-versus-host disease_Homo sapiens_hsa053320.98895627
51Non-small cell lung cancer_Homo sapiens_hsa052230.98186178
52Hepatitis B_Homo sapiens_hsa051610.98133840
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98069395
54Toxoplasmosis_Homo sapiens_hsa051450.98051131
55Phagosome_Homo sapiens_hsa041450.96828820
56Lysosome_Homo sapiens_hsa041420.96185490
57Leishmaniasis_Homo sapiens_hsa051400.95982039
58TNF signaling pathway_Homo sapiens_hsa046680.95443319
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.94302349
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.94180755
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93938713
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93896239
63Asthma_Homo sapiens_hsa053100.93564450
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92713937
65Galactose metabolism_Homo sapiens_hsa000520.91841500
66Fructose and mannose metabolism_Homo sapiens_hsa000510.91542783
67ErbB signaling pathway_Homo sapiens_hsa040120.91312438
68Autoimmune thyroid disease_Homo sapiens_hsa053200.90737835
69Bladder cancer_Homo sapiens_hsa052190.89904264
70Acute myeloid leukemia_Homo sapiens_hsa052210.88511648
71Long-term potentiation_Homo sapiens_hsa047200.87202711
72Prolactin signaling pathway_Homo sapiens_hsa049170.86322171
73Dilated cardiomyopathy_Homo sapiens_hsa054140.86046136
74Salmonella infection_Homo sapiens_hsa051320.85638232
75GnRH signaling pathway_Homo sapiens_hsa049120.84223537
76Insulin resistance_Homo sapiens_hsa049310.84101849
77Platelet activation_Homo sapiens_hsa046110.83562071
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.83201106
79Insulin signaling pathway_Homo sapiens_hsa049100.81574670
80Measles_Homo sapiens_hsa051620.81473670
81T cell receptor signaling pathway_Homo sapiens_hsa046600.81159299
82Vibrio cholerae infection_Homo sapiens_hsa051100.80915215
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78920504
84Chemokine signaling pathway_Homo sapiens_hsa040620.78859570
85Gap junction_Homo sapiens_hsa045400.78791912
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78439440
87Tuberculosis_Homo sapiens_hsa051520.78175064
88Herpes simplex infection_Homo sapiens_hsa051680.77044449
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76406927
90Oxytocin signaling pathway_Homo sapiens_hsa049210.76399282
91Choline metabolism in cancer_Homo sapiens_hsa052310.76342797
92* Endocytosis_Homo sapiens_hsa041440.76042323
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75652371
94Antigen processing and presentation_Homo sapiens_hsa046120.75048363
95Adherens junction_Homo sapiens_hsa045200.74404395
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74162213
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74052589
98Cholinergic synapse_Homo sapiens_hsa047250.73308740
99HIF-1 signaling pathway_Homo sapiens_hsa040660.72502406
100Renin secretion_Homo sapiens_hsa049240.72493963
101Thyroid hormone synthesis_Homo sapiens_hsa049180.72117170
102Synaptic vesicle cycle_Homo sapiens_hsa047210.70502821
103Tight junction_Homo sapiens_hsa045300.69138357
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68851999
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68464173
106Pertussis_Homo sapiens_hsa051330.67791904
107Apoptosis_Homo sapiens_hsa042100.67371360
108ECM-receptor interaction_Homo sapiens_hsa045120.67171549
109Prion diseases_Homo sapiens_hsa050200.65935317
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65073446
111PPAR signaling pathway_Homo sapiens_hsa033200.65013434
112Arginine biosynthesis_Homo sapiens_hsa002200.64396635
113Pentose phosphate pathway_Homo sapiens_hsa000300.64332243
114Hepatitis C_Homo sapiens_hsa051600.63674618
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.62428478
116Type I diabetes mellitus_Homo sapiens_hsa049400.61987377
117Small cell lung cancer_Homo sapiens_hsa052220.61435594
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61406888
119Viral myocarditis_Homo sapiens_hsa054160.60812142
120Rap1 signaling pathway_Homo sapiens_hsa040150.60647037
121Cocaine addiction_Homo sapiens_hsa050300.60450004
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.60374283
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.60125990
124Fatty acid biosynthesis_Homo sapiens_hsa000610.59974285
125Staphylococcus aureus infection_Homo sapiens_hsa051500.58473806
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58181512
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57871226
128Pancreatic secretion_Homo sapiens_hsa049720.56681043
129Insulin secretion_Homo sapiens_hsa049110.56104188
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55525868
131Shigellosis_Homo sapiens_hsa051310.54908040
132Colorectal cancer_Homo sapiens_hsa052100.54867451
133MAPK signaling pathway_Homo sapiens_hsa040100.54242602
134Hematopoietic cell lineage_Homo sapiens_hsa046400.53476777
135Sphingolipid metabolism_Homo sapiens_hsa006000.51171642
136HTLV-I infection_Homo sapiens_hsa051660.48969360
137Renin-angiotensin system_Homo sapiens_hsa046140.46757678

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »