CHMP4BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.63504229
2acrosome reaction (GO:0007340)4.57697275
3regulation of MHC class I biosynthetic process (GO:0045343)4.46429196
4cilium or flagellum-dependent cell motility (GO:0001539)4.44523808
5sperm motility (GO:0030317)4.38598988
6histone H3-K36 demethylation (GO:0070544)4.32272049
7regulation of T-helper 2 cell differentiation (GO:0045628)4.23779442
8establishment of protein localization to Golgi (GO:0072600)4.16428430
9retrograde transport, vesicle recycling within Golgi (GO:0000301)4.15886137
10protein K48-linked deubiquitination (GO:0071108)4.06288920
11positive regulation of granulocyte differentiation (GO:0030854)4.01851943
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99901336
13cellular response to exogenous dsRNA (GO:0071360)3.99762527
14N-terminal protein amino acid acetylation (GO:0006474)3.94089772
15activated T cell proliferation (GO:0050798)3.93866081
16response to interferon-alpha (GO:0035455)3.85986117
17regulation of gamma-delta T cell differentiation (GO:0045586)3.81529301
18B cell receptor signaling pathway (GO:0050853)3.80983848
19regulation of gamma-delta T cell activation (GO:0046643)3.77999186
20cellular response to electrical stimulus (GO:0071257)3.75965579
21protein targeting to Golgi (GO:0000042)3.75927298
22DNA packaging (GO:0006323)3.71809383
23histone H3-K4 trimethylation (GO:0080182)3.68930876
24mature B cell differentiation involved in immune response (GO:0002313)3.67474327
25chromosome condensation (GO:0030261)3.64532526
26regulation of T cell tolerance induction (GO:0002664)3.64279153
27interkinetic nuclear migration (GO:0022027)3.58798961
28histone H3-K9 methylation (GO:0051567)3.58434730
29regulation of tolerance induction (GO:0002643)3.55767361
30phosphatidylethanolamine biosynthetic process (GO:0006646)3.55390548
31peptidyl-lysine trimethylation (GO:0018023)3.53863866
32regulation of granulocyte differentiation (GO:0030852)3.50273186
33regulation of MHC class II biosynthetic process (GO:0045346)3.47725255
34histone H3-K9 modification (GO:0061647)3.46606999
35spermatid nucleus differentiation (GO:0007289)3.45409183
36histone H4 deacetylation (GO:0070933)3.43705084
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.43210915
38type I interferon signaling pathway (GO:0060337)3.42682534
39cellular response to type I interferon (GO:0071357)3.42682534
40response to type I interferon (GO:0034340)3.42345353
41histone H3-K4 methylation (GO:0051568)3.38788242
42positive regulation of type 2 immune response (GO:0002830)3.37019618
43cellular ketone body metabolic process (GO:0046950)3.35288481
44cellular response to reactive nitrogen species (GO:1902170)3.30078032
45cellular response to ethanol (GO:0071361)3.29134560
46positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.27610404
47histone deubiquitination (GO:0016578)3.26119262
48positive regulation of B cell differentiation (GO:0045579)3.24804600
49phosphatidylethanolamine metabolic process (GO:0046337)3.22291027
50regulation of ARF GTPase activity (GO:0032312)3.22026744
51histone lysine demethylation (GO:0070076)3.16340257
52positive regulation of Rab GTPase activity (GO:0032851)3.15748646
53regulation of Rab GTPase activity (GO:0032313)3.15748646
54negative regulation of granulocyte differentiation (GO:0030853)3.15555883
55nucleus organization (GO:0006997)3.14786858
56regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.13973750
57histone H3-K9 demethylation (GO:0033169)3.12948556
58chromatin silencing (GO:0006342)3.12895398
59histone lysine methylation (GO:0034968)3.12523628
60histone demethylation (GO:0016577)3.07050763
61negative regulation of bone resorption (GO:0045779)3.04726214
62regulation of histone H3-K27 methylation (GO:0061085)3.04336176
63coronary vasculature morphogenesis (GO:0060977)2.98604640
64regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.98333195
65response to muramyl dipeptide (GO:0032495)2.97556845
66regulation of RNA export from nucleus (GO:0046831)2.94131428
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.92051586
68regulation of establishment of cell polarity (GO:2000114)2.91120861
69germinal center formation (GO:0002467)2.90353395
70ketone body metabolic process (GO:1902224)2.89999873
71fusion of sperm to egg plasma membrane (GO:0007342)2.88141864
72single strand break repair (GO:0000012)2.88125624
73cellular response to heat (GO:0034605)2.87678153
74sperm capacitation (GO:0048240)2.86646201
75single fertilization (GO:0007338)2.86587565
76mature B cell differentiation (GO:0002335)2.86508438
77negative regulation of inclusion body assembly (GO:0090084)2.84196970
78negative regulation of cAMP-mediated signaling (GO:0043951)2.81449764
79protein demethylation (GO:0006482)2.76039855
80protein dealkylation (GO:0008214)2.76039855
81monoubiquitinated protein deubiquitination (GO:0035520)2.75406250
82receptor catabolic process (GO:0032801)2.74603639
83peptidyl-lysine methylation (GO:0018022)2.73271143
84regulation of B cell receptor signaling pathway (GO:0050855)2.71103211
85positive regulation of CREB transcription factor activity (GO:0032793)2.70678290
86regulation of T-helper cell differentiation (GO:0045622)2.69784096
87cellular extravasation (GO:0045123)2.69753469
88positive regulation of T-helper cell differentiation (GO:0045624)2.69498039
89T-helper cell differentiation (GO:0042093)2.66880373
90CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.66880373
91response to inactivity (GO:0014854)2.63649345
92sexual reproduction (GO:0019953)2.63601763
93nuclear pore complex assembly (GO:0051292)2.63349401
94negative regulation of B cell proliferation (GO:0030889)2.62225331
95hepatocyte apoptotic process (GO:0097284)2.61667163
96production of molecular mediator involved in inflammatory response (GO:0002532)2.61364787
97negative regulation of gene expression, epigenetic (GO:0045814)2.60284627
98interferon-gamma production (GO:0032609)2.57985151
99intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.55643559
100microtubule nucleation (GO:0007020)2.53392495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.61059916
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.38653411
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62890198
4SCL_19346495_ChIP-Seq_HPC-7_Human3.26457975
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22035145
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.98783184
7RUNX_20019798_ChIP-Seq_JUKART_Human2.74806855
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60574862
9SPI1_23127762_ChIP-Seq_K562_Human2.35377742
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34232142
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25097490
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15652937
13MYB_26560356_Chip-Seq_TH2_Human2.13559930
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.12409639
15VDR_24787735_ChIP-Seq_THP-1_Human2.03334570
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01199755
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00738432
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00714205
19VDR_24763502_ChIP-Seq_THP-1_Human1.98714652
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94139479
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.91543510
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.91022141
23VDR_21846776_ChIP-Seq_THP-1_Human1.80858112
24MAF_26560356_Chip-Seq_TH1_Human1.75370441
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73752632
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68747937
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67958126
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66712326
29GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65674602
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64171284
31UTX_26944678_Chip-Seq_JUKART_Human1.62861014
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62407415
33MYB_26560356_Chip-Seq_TH1_Human1.61967312
34MYC_22102868_ChIP-Seq_BL_Human1.61863787
35GATA1_19941826_ChIP-Seq_K562_Human1.61737068
36DROSHA_22980978_ChIP-Seq_HELA_Human1.61538510
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55710255
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55122334
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54255385
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.53544559
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51015742
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45812782
43TCF7_22412390_ChIP-Seq_EML_Mouse1.45241052
44GATA3_27048872_Chip-Seq_THYMUS_Human1.44137464
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.43798734
46SMRT_27268052_Chip-Seq_Bcells_Human1.41740728
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40239762
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39813094
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37972124
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37576977
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.37409217
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37058584
53AHR_22903824_ChIP-Seq_MCF-7_Human1.29931647
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25892408
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25716938
56KDM2B_26808549_Chip-Seq_DND41_Human1.24079471
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23802797
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21751971
59MAF_26560356_Chip-Seq_TH2_Human1.21265456
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20560787
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20087892
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18873796
63CBP_20019798_ChIP-Seq_JUKART_Human1.17963455
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17963455
65SPI1_23547873_ChIP-Seq_NB4_Human1.17889898
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16435837
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16435837
68GATA2_19941826_ChIP-Seq_K562_Human1.13332493
69PU_27001747_Chip-Seq_BMDM_Mouse1.10575462
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09118596
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.08787065
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.08064406
73BCL6_27268052_Chip-Seq_Bcells_Human1.05800178
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04806259
75SPI1_20517297_ChIP-Seq_HL60_Human1.04790480
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04514150
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03383030
78KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02714895
79CIITA_25753668_ChIP-Seq_RAJI_Human1.01227434
80P300_27268052_Chip-Seq_Bcells_Human1.00416525
81GATA3_26560356_Chip-Seq_TH2_Human0.97755026
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97657339
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.97296030
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97056701
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92456320
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91099188
87KLF4_19829295_ChIP-Seq_ESCs_Human0.90309447
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89671676
89SMC4_20622854_ChIP-Seq_HELA_Human0.89508950
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.88850797
91TP63_22573176_ChIP-Seq_HFKS_Human0.86559084
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84903914
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.84232517
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.83812959
95TP53_16413492_ChIP-PET_HCT116_Human0.82889493
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82293243
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81913340
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.81225557
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80646801
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.79131803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.43929284
2MP0005410_abnormal_fertilization3.73848125
3MP0008057_abnormal_DNA_replication3.69986798
4MP0001835_abnormal_antigen_presentation3.42552982
5MP0001986_abnormal_taste_sensitivity3.27864237
6MP0004808_abnormal_hematopoietic_stem3.18598171
7MP0003656_abnormal_erythrocyte_physiolo2.82147697
8MP0009278_abnormal_bone_marrow2.56377024
9MP0002009_preneoplasia2.49543306
10MP0001800_abnormal_humoral_immune2.48692073
11MP0005387_immune_system_phenotype2.46189079
12MP0001790_abnormal_immune_system2.46189079
13MP0005000_abnormal_immune_tolerance2.33673519
14MP0002138_abnormal_hepatobiliary_system2.29714585
15MP0003763_abnormal_thymus_physiology2.22895188
16MP0003172_abnormal_lysosome_physiology2.11165297
17MP0002723_abnormal_immune_serum2.09108386
18MP0002419_abnormal_innate_immunity2.08347380
19MP0005423_abnormal_somatic_nervous2.06196820
20MP0008961_abnormal_basal_metabolism1.94688129
21MP0002166_altered_tumor_susceptibility1.92074594
22MP0001545_abnormal_hematopoietic_system1.89301757
23MP0005397_hematopoietic_system_phenotyp1.89301757
24MP0002452_abnormal_antigen_presenting1.85688188
25MP0009115_abnormal_fat_cell1.85200908
26MP0002420_abnormal_adaptive_immunity1.84027265
27MP0001853_heart_inflammation1.83621157
28MP0000015_abnormal_ear_pigmentation1.82776211
29MP0002398_abnormal_bone_marrow1.81435022
30MP0001819_abnormal_immune_cell1.80517413
31MP0003436_decreased_susceptibility_to1.78892477
32MP0003646_muscle_fatigue1.74901252
33MP0005025_abnormal_response_to1.71345986
34MP0005174_abnormal_tail_pigmentation1.69692283
35MP0005409_darkened_coat_color1.67746491
36MP0000716_abnormal_immune_system1.65194153
37MP0002396_abnormal_hematopoietic_system1.61199583
38MP0004381_abnormal_hair_follicle1.55375464
39MP0002006_tumorigenesis1.54128316
40MP0005451_abnormal_body_composition1.52676420
41MP0009785_altered_susceptibility_to1.52438955
42MP0002405_respiratory_system_inflammati1.52424871
43MP0002332_abnormal_exercise_endurance1.51066919
44MP0003724_increased_susceptibility_to1.48771666
45MP0000689_abnormal_spleen_morphology1.45757534
46MP0004947_skin_inflammation1.42116645
47MP0002722_abnormal_immune_system1.37432136
48MP0000703_abnormal_thymus_morphology1.31295244
49MP0002429_abnormal_blood_cell1.29786293
50MP0004264_abnormal_extraembryonic_tissu1.29471070
51MP0005671_abnormal_response_to1.26299724
52MP0002132_abnormal_respiratory_system1.22332697
53MP0000003_abnormal_adipose_tissue1.17977239
54MP0001873_stomach_inflammation1.17280277
55MP0005083_abnormal_biliary_tract1.14476353
56MP0003300_gastrointestinal_ulcer1.14280686
57MP0009764_decreased_sensitivity_to1.13126649
58MP0003303_peritoneal_inflammation1.12858663
59MP0003698_abnormal_male_reproductive1.12565644
60MP0004233_abnormal_muscle_weight1.11168311
61MP0002998_abnormal_bone_remodeling1.10707236
62MP0005310_abnormal_salivary_gland1.09182158
63MP0002970_abnormal_white_adipose1.06511634
64MP0005379_endocrine/exocrine_gland_phen1.03524045
65MP0001845_abnormal_inflammatory_respons0.95771507
66MP0005075_abnormal_melanosome_morpholog0.92085240
67MP0005076_abnormal_cell_differentiation0.91441014
68MP0005464_abnormal_platelet_physiology0.88639620
69MP0010155_abnormal_intestine_physiology0.86618947
70MP0002822_catalepsy0.86419389
71MP0003828_pulmonary_edema0.85932183
72MP0005377_hearing/vestibular/ear_phenot0.84344825
73MP0003878_abnormal_ear_physiology0.84344825
74MP0004484_altered_response_of0.82522221
75MP0003045_fibrosis0.82285418
76MP0001348_abnormal_lacrimal_gland0.79311683
77MP0001929_abnormal_gametogenesis0.78919858
78MP0000383_abnormal_hair_follicle0.77904556
79MP0003091_abnormal_cell_migration0.77888868
80MP0001533_abnormal_skeleton_physiology0.76544195
81MP0005334_abnormal_fat_pad0.76476096
82MP0000685_abnormal_immune_system0.76188822
83MP0008469_abnormal_protein_level0.75568333
84MP0000733_abnormal_muscle_development0.73643192
85MP0005670_abnormal_white_adipose0.70259078
86MP0005167_abnormal_blood-brain_barrier0.68509964
87MP0002148_abnormal_hypersensitivity_rea0.67071294
88MP0002928_abnormal_bile_duct0.66834429
89MP0002019_abnormal_tumor_incidence0.66434894
90MP0000858_altered_metastatic_potential0.66120220
91MP0003787_abnormal_imprinting0.65932274
92MP0009765_abnormal_xenobiotic_induced0.65383975
93MP0005166_decreased_susceptibility_to0.65306835
94MP0010307_abnormal_tumor_latency0.65188838
95MP0003115_abnormal_respiratory_system0.63357451
96MP0005375_adipose_tissue_phenotype0.63247890
97MP0000249_abnormal_blood_vessel0.62617338
98MP0003075_altered_response_to0.61949380
99MP0004510_myositis0.61847087
100MP0005058_abnormal_lysosome_morphology0.60234373

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)9.06322848
2Progressive cerebellar ataxia (HP:0002073)5.42421862
3Abnormality of the fingertips (HP:0001211)5.20399117
4Abnormality of the columella (HP:0009929)5.18268844
5Impulsivity (HP:0100710)4.46244532
6Panhypogammaglobulinemia (HP:0003139)4.18152405
7Slow saccadic eye movements (HP:0000514)4.04867258
8Colitis (HP:0002583)3.89941431
9Obstructive sleep apnea (HP:0002870)3.73484048
10Broad face (HP:0000283)3.71585587
11Abnormality of incisor morphology (HP:0011063)3.68385744
12Abnormality of the aortic arch (HP:0012303)3.51032480
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.49705286
14Recurrent cutaneous fungal infections (HP:0011370)3.47141520
15Chronic mucocutaneous candidiasis (HP:0002728)3.47141520
16Recurrent viral infections (HP:0004429)3.44116212
17Pigmentary retinal degeneration (HP:0001146)3.42960073
18Severe visual impairment (HP:0001141)3.39680862
19Spondylolisthesis (HP:0003302)3.38797824
20Postural instability (HP:0002172)3.28772091
21Recurrent fungal infections (HP:0002841)3.25887050
22Hypoplasia of the thymus (HP:0000778)3.20905595
23Supernumerary nipples (HP:0002558)3.20493797
24Abnormal hair whorl (HP:0010721)3.19569657
25Distal lower limb amyotrophy (HP:0008944)3.14658935
26Acute myeloid leukemia (HP:0004808)3.14435640
27Self-mutilation (HP:0000742)3.13938064
28Truncal obesity (HP:0001956)3.11798427
29Abnormality of the nasal septum (HP:0000419)3.01535354
30Abnormality of the phalanges of the hallux (HP:0010057)2.88241116
31Recurrent bacterial skin infections (HP:0005406)2.85198304
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74094456
33Inflammation of the large intestine (HP:0002037)2.62947782
34Recurrent abscess formation (HP:0002722)2.61820369
35Agammaglobulinemia (HP:0004432)2.57475727
36Hemiplegia (HP:0002301)2.54321907
37Recurrent skin infections (HP:0001581)2.51775621
38Viral hepatitis (HP:0006562)2.50889048
39Submucous cleft hard palate (HP:0000176)2.47955039
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.47029326
41Absent/shortened dynein arms (HP:0200106)2.47029326
42Acute lymphatic leukemia (HP:0006721)2.45890641
43Narrow palate (HP:0000189)2.45782368
44Dysmetric saccades (HP:0000641)2.45134976
45Gastrointestinal inflammation (HP:0004386)2.40176449
46Flared iliac wings (HP:0002869)2.34806524
47Abnormality of T cell physiology (HP:0011840)2.33682951
48Vasculitis (HP:0002633)2.25906851
49Low anterior hairline (HP:0000294)2.24142823
50Conjunctival telangiectasia (HP:0000524)2.21113254
51Abnormality of the nasal mucosa (HP:0000433)2.20941486
52Laryngomalacia (HP:0001601)2.19155834
53Aplasia/Hypoplasia of the thymus (HP:0010515)2.18934414
54Gingivitis (HP:0000230)2.18460271
55Spontaneous hematomas (HP:0007420)2.17628722
56Abnormality of the parietal bone (HP:0002696)2.17336172
57Abnormality of T cells (HP:0002843)2.16449649
58Macular degeneration (HP:0000608)2.16358011
59Long eyelashes (HP:0000527)2.10035608
60Villous atrophy (HP:0011473)2.08287880
61Abnormality of small intestinal villus morphology (HP:0011472)2.08287880
62Leukocytosis (HP:0001974)2.06795679
63Abnormality of saccadic eye movements (HP:0000570)2.05573932
64Lower limb amyotrophy (HP:0007210)2.05059255
65T lymphocytopenia (HP:0005403)2.04770776
66Recurrent sinusitis (HP:0011108)2.04478139
67Stereotypic behavior (HP:0000733)2.03259342
68Bowel incontinence (HP:0002607)2.03034958
69Abnormality of the incisor (HP:0000676)2.02096224
70Abnormality of the distal phalanx of the thumb (HP:0009617)2.00646961
71Fatigue (HP:0012378)1.99634318
72Granulocytopenia (HP:0001913)1.98744144
73Eosinophilia (HP:0001880)1.92339630
74Abnormal large intestine physiology (HP:0012700)1.92056356
75Hypoplastic iliac wings (HP:0002866)1.91458166
76Supranuclear gaze palsy (HP:0000605)1.90536470
77Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90198840
78Abnormality of binocular vision (HP:0011514)1.86888563
79Diplopia (HP:0000651)1.86888563
80Hemoptysis (HP:0002105)1.83988137
81Hematochezia (HP:0002573)1.83792076
82Meningitis (HP:0001287)1.83496294
83Lymphopenia (HP:0001888)1.82704669
84Abnormality of chromosome segregation (HP:0002916)1.80030964
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79171867
86Hypoplastic ischia (HP:0003175)1.78765761
87Gastrointestinal stroma tumor (HP:0100723)1.77647264
88Gastrointestinal infarctions (HP:0005244)1.77215661
89Cone-rod dystrophy (HP:0000548)1.76562896
90Nasal polyposis (HP:0100582)1.76025649
91Prolonged bleeding time (HP:0003010)1.73601851
92Encephalitis (HP:0002383)1.73187051
93Abnormality of T cell number (HP:0011839)1.72616540
94Thick eyebrow (HP:0000574)1.72046991
95Epistaxis (HP:0000421)1.69580120
96Gingival bleeding (HP:0000225)1.69557494
97Myositis (HP:0100614)1.68477609
98Retrobulbar optic neuritis (HP:0100654)1.67919254
99Optic neuritis (HP:0100653)1.67919254
100Abnormality of the thoracic spine (HP:0100711)1.65331276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.64417488
2MAP3K63.85690330
3MARK22.95208683
4PTK2B2.81943998
5TXK2.72767750
6CDC42BPA2.63353779
7MAP3K42.52953271
8MAP4K12.46614494
9BLK2.39586854
10RIPK42.33371661
11STK382.18620148
12MAP2K72.04327570
13JAK11.99486512
14BTK1.73955226
15MAP3K71.71412643
16JAK31.70625981
17CAMK1G1.69987606
18CAMK41.65778415
19SYK1.64775020
20CAMK1D1.52941508
21PLK41.46324746
22GRK61.44805648
23CHUK1.44328644
24ZAP701.35732405
25ERN11.32010900
26WNK11.31884900
27TNK21.29505021
28MAP2K41.29010094
29MAP3K51.26218401
30PDK11.25861594
31BRD41.25732300
32IRAK41.24482353
33FGFR41.22481393
34NEK61.20488548
35FES1.19691627
36PDPK11.17934200
37KIT1.16438842
38HCK1.15163034
39IKBKE1.13738381
40NLK1.12440842
41PDK21.11632754
42TEC1.11463226
43CDK31.11048822
44PRKD21.10804019
45TAOK11.09527687
46RET1.06813561
47TYK21.03878727
48BMPR21.03306814
49IKBKB1.00760186
50MAPK111.00701740
51MTOR0.95116990
52LYN0.91605869
53MAP3K100.89802228
54CDK40.89119843
55TYRO30.85931073
56STK100.83890198
57MELK0.83137429
58ITK0.77908690
59MAP2K30.75168677
60MAP3K140.74810444
61FRK0.74773467
62PRKD30.74746729
63ERBB20.73525207
64CDK60.72559175
65FGFR30.72044743
66MAPK70.68844563
67PIK3CG0.68399013
68LCK0.67243858
69CHEK20.60380510
70ICK0.59827178
71MAPK10.59791973
72SGK20.58784512
73FGFR20.58724432
74EIF2AK20.56266025
75MAPK100.56237886
76PRKCH0.55800979
77TBK10.55653377
78DYRK1B0.54894915
79CHEK10.54258298
80MAP3K30.53515804
81FLT30.52864721
82MAP4K20.50700233
83STK40.50071580
84PDGFRB0.49748601
85SIK20.48813030
86CAMK10.43186944
87MAPK150.42919543
88IRAK30.42679582
89JAK20.40810659
90DDR20.39154682
91MAPK120.38237937
92GSK3B0.36939696
93CSF1R0.36547833
94MAP3K10.36283032
95MATK0.35910075
96PIM10.35299171
97SGK30.35239926
98MAPK30.33834526
99MAPK80.33792877
100TRIB30.33683422

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.40058823
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19815570
3Influenza A_Homo sapiens_hsa051642.06134918
4Allograft rejection_Homo sapiens_hsa053302.03368972
5Primary immunodeficiency_Homo sapiens_hsa053401.94359530
6Autoimmune thyroid disease_Homo sapiens_hsa053201.91798527
7B cell receptor signaling pathway_Homo sapiens_hsa046621.84700246
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.83840246
9Leishmaniasis_Homo sapiens_hsa051401.83559343
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72746965
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.68843050
12Osteoclast differentiation_Homo sapiens_hsa043801.68599553
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61730001
14Acute myeloid leukemia_Homo sapiens_hsa052211.59388435
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56124361
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51826754
17Herpes simplex infection_Homo sapiens_hsa051681.50574743
18Notch signaling pathway_Homo sapiens_hsa043301.48616871
19Type I diabetes mellitus_Homo sapiens_hsa049401.48476058
20Toxoplasmosis_Homo sapiens_hsa051451.47910109
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47641544
22Tuberculosis_Homo sapiens_hsa051521.46983979
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45932444
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45057895
25Choline metabolism in cancer_Homo sapiens_hsa052311.44191519
26Inositol phosphate metabolism_Homo sapiens_hsa005621.43917587
27Viral myocarditis_Homo sapiens_hsa054161.42722271
28Antigen processing and presentation_Homo sapiens_hsa046121.40773305
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37448990
30Epstein-Barr virus infection_Homo sapiens_hsa051691.35536314
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35396785
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34456600
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.33808553
34Other glycan degradation_Homo sapiens_hsa005111.30281547
35Lysine degradation_Homo sapiens_hsa003101.29472930
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.29245661
37Measles_Homo sapiens_hsa051621.26451915
38Hepatitis B_Homo sapiens_hsa051611.20451541
39Non-small cell lung cancer_Homo sapiens_hsa052231.18193358
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14161533
41Staphylococcus aureus infection_Homo sapiens_hsa051501.13625558
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12753573
43T cell receptor signaling pathway_Homo sapiens_hsa046601.12626988
44TNF signaling pathway_Homo sapiens_hsa046681.12292944
45Dorso-ventral axis formation_Homo sapiens_hsa043201.11789883
46Asthma_Homo sapiens_hsa053101.10580874
47FoxO signaling pathway_Homo sapiens_hsa040681.04498899
48Hematopoietic cell lineage_Homo sapiens_hsa046401.03438479
49Type II diabetes mellitus_Homo sapiens_hsa049301.01037370
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.99445688
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.98976911
52Malaria_Homo sapiens_hsa051440.96834260
53Hepatitis C_Homo sapiens_hsa051600.96686941
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96217950
55Fatty acid biosynthesis_Homo sapiens_hsa000610.94788139
56Prostate cancer_Homo sapiens_hsa052150.93651379
57Chronic myeloid leukemia_Homo sapiens_hsa052200.91646635
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88818777
59Olfactory transduction_Homo sapiens_hsa047400.88334282
60Insulin resistance_Homo sapiens_hsa049310.88314936
61Viral carcinogenesis_Homo sapiens_hsa052030.85791640
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85528394
63Prolactin signaling pathway_Homo sapiens_hsa049170.85249410
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.83330436
65VEGF signaling pathway_Homo sapiens_hsa043700.82979458
66GnRH signaling pathway_Homo sapiens_hsa049120.81946421
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81445389
68Pancreatic cancer_Homo sapiens_hsa052120.81144959
69ErbB signaling pathway_Homo sapiens_hsa040120.77204539
70Renal cell carcinoma_Homo sapiens_hsa052110.75199717
71Chemokine signaling pathway_Homo sapiens_hsa040620.73723776
72mTOR signaling pathway_Homo sapiens_hsa041500.71019365
73MicroRNAs in cancer_Homo sapiens_hsa052060.70927770
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.67859589
75Endocytosis_Homo sapiens_hsa041440.65571849
76Estrogen signaling pathway_Homo sapiens_hsa049150.65056907
77HTLV-I infection_Homo sapiens_hsa051660.64946773
78Pertussis_Homo sapiens_hsa051330.64791294
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63852925
80Calcium signaling pathway_Homo sapiens_hsa040200.62764409
81mRNA surveillance pathway_Homo sapiens_hsa030150.59371396
82Apoptosis_Homo sapiens_hsa042100.58109156
83Platelet activation_Homo sapiens_hsa046110.56452446
84Legionellosis_Homo sapiens_hsa051340.55028800
85Rheumatoid arthritis_Homo sapiens_hsa053230.53337715
86Adherens junction_Homo sapiens_hsa045200.52984241
87Glioma_Homo sapiens_hsa052140.52683982
88Thyroid cancer_Homo sapiens_hsa052160.51671702
89HIF-1 signaling pathway_Homo sapiens_hsa040660.50608272
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50122913
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.48736031
92Systemic lupus erythematosus_Homo sapiens_hsa053220.48505586
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46906830
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46864981
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46834099
96Basal transcription factors_Homo sapiens_hsa030220.46481799
97Oocyte meiosis_Homo sapiens_hsa041140.45835975
98MAPK signaling pathway_Homo sapiens_hsa040100.44840604
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42263486
100Colorectal cancer_Homo sapiens_hsa052100.42062895

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