CHMP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.71562204
2protein deneddylation (GO:0000338)4.87143320
3signal peptide processing (GO:0006465)4.42302958
4axon ensheathment in central nervous system (GO:0032291)4.32786629
5central nervous system myelination (GO:0022010)4.32786629
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.18833553
7platelet dense granule organization (GO:0060155)4.03270638
8protein neddylation (GO:0045116)4.03268391
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.99707592
10fatty acid elongation (GO:0030497)3.96582061
11long-chain fatty acid biosynthetic process (GO:0042759)3.89138244
12ER overload response (GO:0006983)3.62793662
13nucleotide transmembrane transport (GO:1901679)3.62576516
14protein localization to cilium (GO:0061512)3.57578147
15positive regulation of actin filament depolymerization (GO:0030836)3.54375974
16regulation of cellular amino acid metabolic process (GO:0006521)3.47081050
17sequestering of actin monomers (GO:0042989)3.41206457
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37844434
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36412000
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36266087
21ATP synthesis coupled proton transport (GO:0015986)3.36266087
22respiratory chain complex IV assembly (GO:0008535)3.34449375
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34238206
24phagosome maturation (GO:0090382)3.27984531
25organelle disassembly (GO:1903008)3.27824051
26regulation of cilium movement (GO:0003352)3.26458436
27ribonucleoprotein complex disassembly (GO:0032988)3.25390738
28neutrophil activation involved in immune response (GO:0002283)3.22786014
29epithelial cilium movement (GO:0003351)3.21278286
30protein K11-linked ubiquitination (GO:0070979)3.19664114
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16612436
32respiratory electron transport chain (GO:0022904)3.14197348
33negative regulation of ligase activity (GO:0051352)3.11088436
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11088436
35response to redox state (GO:0051775)3.10360791
36electron transport chain (GO:0022900)3.07894600
37limb bud formation (GO:0060174)3.06971011
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01234175
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.01214132
40ATP hydrolysis coupled proton transport (GO:0015991)3.01214132
41transferrin transport (GO:0033572)3.00079398
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99818358
43heart contraction (GO:0060047)2.97392067
44heart process (GO:0003015)2.97392067
45peroxisome fission (GO:0016559)2.97132534
46DNA damage response, detection of DNA damage (GO:0042769)2.96717986
47positive regulation of mitochondrial fission (GO:0090141)2.95470878
48cellular copper ion homeostasis (GO:0006878)2.93857972
49water-soluble vitamin biosynthetic process (GO:0042364)2.92201260
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91748032
51protein localization to mitochondrion (GO:0070585)2.91651315
52negative regulation of membrane potential (GO:0045837)2.90606941
53positive regulation of ligase activity (GO:0051351)2.90408835
54protein complex biogenesis (GO:0070271)2.86434428
55ferric iron transport (GO:0015682)2.85861923
56trivalent inorganic cation transport (GO:0072512)2.85861923
57membrane budding (GO:0006900)2.85174481
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81685756
59cytochrome complex assembly (GO:0017004)2.80825889
60substantia nigra development (GO:0021762)2.80806200
61negative regulation of neurotransmitter transport (GO:0051589)2.78971911
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77926744
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77926744
64chaperone-mediated protein transport (GO:0072321)2.77285359
65cholesterol biosynthetic process (GO:0006695)2.77157694
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76273067
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76273067
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76273067
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75579448
70anterograde synaptic vesicle transport (GO:0048490)2.74882578
71DNA double-strand break processing (GO:0000729)2.71425288
72viral protein processing (GO:0019082)2.71338104
73protein targeting to mitochondrion (GO:0006626)2.70414500
74protein maturation by protein folding (GO:0022417)2.70158467
75C-terminal protein lipidation (GO:0006501)2.70121615
76glycosphingolipid biosynthetic process (GO:0006688)2.69157564
77negative regulation of neurotransmitter secretion (GO:0046929)2.68370805
78protein-cofactor linkage (GO:0018065)2.68061462
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67566879
80aldehyde catabolic process (GO:0046185)2.67231745
81ribosome assembly (GO:0042255)2.67133126
82keratinocyte development (GO:0003334)2.66770020
83regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.66715798
84autophagic vacuole fusion (GO:0000046)2.66160055
85eosinophil chemotaxis (GO:0048245)2.65201099
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61947497
87establishment of viral latency (GO:0019043)2.61618957
88copper ion homeostasis (GO:0055070)2.60914720
89cilium movement (GO:0003341)2.60270588
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.60260978
91negative regulation of JUN kinase activity (GO:0043508)2.60170240
92amyloid precursor protein catabolic process (GO:0042987)2.60131846
93regulation of mitochondrial translation (GO:0070129)2.60029175
94axonemal dynein complex assembly (GO:0070286)2.59040387
95dopamine biosynthetic process (GO:0042416)2.58255059
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.57822969
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57822969
98de novo protein folding (GO:0006458)2.57575521
99establishment of protein localization to mitochondrion (GO:0072655)2.57537279
100regulation of cellular amine metabolic process (GO:0033238)2.56014194
101regulation of ubiquitin-protein transferase activity (GO:0051438)2.55953099
102pH reduction (GO:0045851)2.55432020
103positive regulation of monocyte chemotaxis (GO:0090026)2.52850878
104lipid particle organization (GO:0034389)2.52131661
105regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51506999
106presynaptic membrane assembly (GO:0097105)2.51322832
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51318725
108C-terminal protein amino acid modification (GO:0018410)2.51054234
109de novo posttranslational protein folding (GO:0051084)2.50656279
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49685707
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49685707
112intracellular pH reduction (GO:0051452)2.49120593
113regulation of ligase activity (GO:0051340)2.48862440
114cilium morphogenesis (GO:0060271)2.48453615
115nonmotile primary cilium assembly (GO:0035058)2.47236156
116sterol biosynthetic process (GO:0016126)2.47022139
117regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.46542366
118positive regulation of protein autophosphorylation (GO:0031954)2.46482721
119glutathione derivative biosynthetic process (GO:1901687)2.46105923
120glutathione derivative metabolic process (GO:1901685)2.46105923
121amyloid precursor protein metabolic process (GO:0042982)2.43032297
122hydrogen ion transmembrane transport (GO:1902600)2.42871805
123cullin deneddylation (GO:0010388)2.42476384
124positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.42272074
125isoprenoid biosynthetic process (GO:0008299)2.41012324
126establishment of melanosome localization (GO:0032401)2.39717787
127regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.39578903
128mitochondrial calcium ion homeostasis (GO:0051560)2.38004258
129proton transport (GO:0015992)2.37096760
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36682125
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.36682125
132NADH dehydrogenase complex assembly (GO:0010257)2.36682125
133superoxide anion generation (GO:0042554)2.36472590
134presynaptic membrane organization (GO:0097090)2.35581171
135catecholamine biosynthetic process (GO:0042423)2.35405754
136catechol-containing compound biosynthetic process (GO:0009713)2.35405754
137magnesium ion transport (GO:0015693)2.35281346
138endocrine pancreas development (GO:0031018)2.33464432
139peptide hormone processing (GO:0016486)2.33303445
140mannosylation (GO:0097502)2.31667972
141hydrogen transport (GO:0006818)2.31662609
142eosinophil migration (GO:0072677)2.31131361
143mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.30973727
144positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.30973727
145regulation of collateral sprouting (GO:0048670)2.30846271
146removal of superoxide radicals (GO:0019430)2.30614769
147cellular response to superoxide (GO:0071451)2.30614769
148cellular response to oxygen radical (GO:0071450)2.30614769
149eye photoreceptor cell differentiation (GO:0001754)2.30291774
150photoreceptor cell differentiation (GO:0046530)2.30291774
151estrogen biosynthetic process (GO:0006703)2.29626843
152mitochondrial respiratory chain complex assembly (GO:0033108)2.29159143
153long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.28472216
154intraciliary transport (GO:0042073)2.28302594
155sphingoid metabolic process (GO:0046519)2.27503120
156establishment of pigment granule localization (GO:0051905)2.27048950
157hydrogen peroxide biosynthetic process (GO:0050665)2.24591184
158GPI anchor biosynthetic process (GO:0006506)2.23061188
159organelle membrane fusion (GO:0090174)2.20360503
160myelination (GO:0042552)2.19437629
161neurofilament cytoskeleton organization (GO:0060052)2.18652239
162positive regulation of TOR signaling (GO:0032008)2.18594105
163positive regulation of oligodendrocyte differentiation (GO:0048714)2.18434399
164axon ensheathment (GO:0008366)2.17483547
165ensheathment of neurons (GO:0007272)2.17483547
166melanosome transport (GO:0032402)2.16683012
167positive regulation of amino acid transport (GO:0051957)2.16490276
168long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.14458378
169membrane assembly (GO:0071709)2.14240121
170negative regulation of dendrite morphogenesis (GO:0050774)2.13846905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65456636
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38387019
3EST1_17652178_ChIP-ChIP_JURKAT_Human2.83864265
4GBX2_23144817_ChIP-Seq_PC3_Human2.75236646
5* ELK1_19687146_ChIP-ChIP_HELA_Human2.71965443
6VDR_22108803_ChIP-Seq_LS180_Human2.51019538
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45674134
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40203696
9TAF15_26573619_Chip-Seq_HEK293_Human2.38386663
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37538214
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27774205
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27190102
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14778584
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07056629
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95996691
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95146220
17ZNF274_21170338_ChIP-Seq_K562_Hela1.94150112
18EWS_26573619_Chip-Seq_HEK293_Human1.92662360
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86363627
20P300_19829295_ChIP-Seq_ESCs_Human1.85965486
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84316936
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.83819120
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.83819120
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.82817514
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82316818
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80781801
27* VDR_23849224_ChIP-Seq_CD4+_Human1.80628435
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71113743
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70252749
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69478321
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66555039
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.64142024
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63207914
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.63107086
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.62718959
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56379918
37ER_23166858_ChIP-Seq_MCF-7_Human1.55901316
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52997878
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52107242
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52003466
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51757759
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51137916
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46706877
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.44829972
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44757966
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41952347
47DCP1A_22483619_ChIP-Seq_HELA_Human1.41519004
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41019530
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40628482
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.40051091
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.39930158
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.39910027
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39280977
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39127239
55FUS_26573619_Chip-Seq_HEK293_Human1.38290081
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.37214802
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37087617
58SOX2_20726797_ChIP-Seq_SW620_Human1.36961841
59* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35628012
60SMAD4_21799915_ChIP-Seq_A2780_Human1.33159431
61TP53_18474530_ChIP-ChIP_U2OS_Human1.32461037
62* ELK1_22589737_ChIP-Seq_MCF10A_Human1.30678607
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30659699
64MYC_18940864_ChIP-ChIP_HL60_Human1.30455557
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28332998
66CBP_20019798_ChIP-Seq_JUKART_Human1.28332998
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28246248
68RNF2_27304074_Chip-Seq_NSC_Mouse1.27245418
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26917971
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26474429
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26343446
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26322863
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.26115848
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25242951
75HTT_18923047_ChIP-ChIP_STHdh_Human1.24956979
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24854173
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.23707268
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.23124508
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.22700850
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21836264
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21549081
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.21352321
83IGF1R_20145208_ChIP-Seq_DFB_Human1.20648846
84P53_22387025_ChIP-Seq_ESCs_Mouse1.20583144
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19100311
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19057611
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.18244279
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18135384
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16246820
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.14877488
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14536442
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13933153
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13287164
94* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13043023
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12989963
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.12313500
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.12266790
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.11762209
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11723811
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.11493690
101* GABP_17652178_ChIP-ChIP_JURKAT_Human1.10945749
102SOX2_19829295_ChIP-Seq_ESCs_Human1.10707761
103NANOG_19829295_ChIP-Seq_ESCs_Human1.10707761
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.10668325
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10664932
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10179402
107P300_18555785_Chip-Seq_ESCs_Mouse1.08294001
108FOXP3_21729870_ChIP-Seq_TREG_Human1.08167437
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08165996
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.08165996
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07302369
112EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07289558
113RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07289558
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05437189
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04905416
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04689810
117JUN_21703547_ChIP-Seq_K562_Human1.04481379
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04430464
119NMYC_18555785_Chip-Seq_ESCs_Mouse1.04315452
120CDX2_22108803_ChIP-Seq_LS180_Human1.03689222
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03565948
122TCF4_22108803_ChIP-Seq_LS180_Human1.03383618
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.03033829
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.03004722
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02567133
126* TP53_22573176_ChIP-Seq_HFKS_Human1.01733481
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.01644604
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01594998
129CJUN_26792858_Chip-Seq_BT549_Human1.01455625
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.01135041
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.00701528
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00249835
133AR_25329375_ChIP-Seq_VCAP_Human0.99737621
134RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99514779
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98590349
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98526081
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97882452
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.93446245
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.93378659
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93181097
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92370033
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92353790
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92257445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.25498969
2MP0006054_spinal_hemorrhage3.16851533
3MP0003880_abnormal_central_pattern2.82210101
4MP0002102_abnormal_ear_morphology2.81781333
5MP0003195_calcinosis2.75793573
6MP0000013_abnormal_adipose_tissue2.59829785
7MP0005379_endocrine/exocrine_gland_phen2.57131883
8MP0009780_abnormal_chondrocyte_physiolo2.44371568
9MP0000920_abnormal_myelination2.31625303
10MP0002163_abnormal_gland_morphology2.27276507
11MP0003806_abnormal_nucleotide_metabolis2.25558183
12MP0004043_abnormal_pH_regulation2.16268095
13MP0002876_abnormal_thyroid_physiology2.13879130
14MP0004270_analgesia2.13078635
15MP0005171_absent_coat_pigmentation2.11890717
16MP0005408_hypopigmentation2.06312390
17MP0002877_abnormal_melanocyte_morpholog2.03769093
18MP0001905_abnormal_dopamine_level2.01857299
19MP0001986_abnormal_taste_sensitivity2.01841952
20MP0006276_abnormal_autonomic_nervous1.95762843
21MP0004215_abnormal_myocardial_fiber1.88720911
22MP0003136_yellow_coat_color1.85876770
23MP0001529_abnormal_vocalization1.84766594
24MP0002734_abnormal_mechanical_nocicepti1.78897638
25MP0005645_abnormal_hypothalamus_physiol1.76533137
26MP0001346_abnormal_lacrimal_gland1.71766409
27MP0000372_irregular_coat_pigmentation1.68454712
28MP0002638_abnormal_pupillary_reflex1.68450565
29MP0001984_abnormal_olfaction1.68450390
30MP0002295_abnormal_pulmonary_circulatio1.68437699
31MP0002735_abnormal_chemical_nociception1.67143259
32MP0008875_abnormal_xenobiotic_pharmacok1.63982253
33MP0005367_renal/urinary_system_phenotyp1.57196152
34MP0000516_abnormal_urinary_system1.57196152
35MP0004742_abnormal_vestibular_system1.56239434
36MP0003183_abnormal_peptide_metabolism1.55564142
37MP0002277_abnormal_respiratory_mucosa1.55229943
38MP0002139_abnormal_hepatobiliary_system1.52438755
39MP0003787_abnormal_imprinting1.51437450
40MP0002272_abnormal_nervous_system1.51196190
41MP0000427_abnormal_hair_cycle1.51070126
42MP0002148_abnormal_hypersensitivity_rea1.50995219
43MP0002733_abnormal_thermal_nociception1.50773561
44MP0003724_increased_susceptibility_to1.50633394
45MP0006036_abnormal_mitochondrial_physio1.49907345
46MP0010234_abnormal_vibrissa_follicle1.49548244
47MP0000566_synostosis1.48926422
48MP0004147_increased_porphyrin_level1.48350987
49MP0002909_abnormal_adrenal_gland1.47937869
50MP0001970_abnormal_pain_threshold1.46823285
51MP0008877_abnormal_DNA_methylation1.46751029
52MP0002138_abnormal_hepatobiliary_system1.44819455
53MP0000569_abnormal_digit_pigmentation1.40723344
54MP0005084_abnormal_gallbladder_morpholo1.40556402
55MP0003950_abnormal_plasma_membrane1.39208348
56MP0006072_abnormal_retinal_apoptosis1.39084259
57MP0003186_abnormal_redox_activity1.39036154
58MP0009697_abnormal_copulation1.38751929
59MP0003011_delayed_dark_adaptation1.38563898
60MP0002693_abnormal_pancreas_physiology1.36933347
61MP0000647_abnormal_sebaceous_gland1.35346929
62MP0003221_abnormal_cardiomyocyte_apopto1.34684137
63MP0003718_maternal_effect1.31324645
64MP0002234_abnormal_pharynx_morphology1.28954304
65MP0002254_reproductive_system_inflammat1.28846621
66MP0001188_hyperpigmentation1.28263437
67MP0005332_abnormal_amino_acid1.25674076
68MP0008789_abnormal_olfactory_epithelium1.25348293
69MP0003634_abnormal_glial_cell1.24154169
70MP0000538_abnormal_urinary_bladder1.23325149
71MP0002064_seizures1.21508239
72MP0005310_abnormal_salivary_gland1.21469286
73MP0001968_abnormal_touch/_nociception1.19748799
74MP0004782_abnormal_surfactant_physiolog1.19577230
75MP0001440_abnormal_grooming_behavior1.19501845
76MP0003690_abnormal_glial_cell1.18582372
77MP0001542_abnormal_bone_strength1.16881563
78MP0009745_abnormal_behavioral_response1.16024139
79MP0000778_abnormal_nervous_system1.12252462
80MP0008260_abnormal_autophagy1.11997840
81MP0002736_abnormal_nociception_after1.11668118
82MP0001764_abnormal_homeostasis1.11559507
83MP0001501_abnormal_sleep_pattern1.07707109
84MP0000343_altered_response_to1.07373354
85MP0009379_abnormal_foot_pigmentation1.05381237
86MP0006035_abnormal_mitochondrial_morpho1.04954097
87MP0002653_abnormal_ependyma_morphology1.03544461
88MP0005646_abnormal_pituitary_gland1.03500776
89MP0004924_abnormal_behavior1.03491024
90MP0005386_behavior/neurological_phenoty1.03491024
91MP0002938_white_spotting1.03134077
92MP0004019_abnormal_vitamin_homeostasis1.02479082
93MP0002837_dystrophic_cardiac_calcinosis1.02455750
94MP0001485_abnormal_pinna_reflex1.01981786
95MP0005410_abnormal_fertilization1.01435004
96MP0005058_abnormal_lysosome_morphology1.01429040
97MP0009046_muscle_twitch1.01310564
98MP0004142_abnormal_muscle_tone1.01001393
99MP0001502_abnormal_circadian_rhythm1.00326417
100MP0002009_preneoplasia1.00081761
101MP0004381_abnormal_hair_follicle0.99715375
102MP0002822_catalepsy0.98339730
103MP0002332_abnormal_exercise_endurance0.96947790
104MP0005085_abnormal_gallbladder_physiolo0.96744580
105MP0005499_abnormal_olfactory_system0.96325005
106MP0005394_taste/olfaction_phenotype0.96325005
107MP0002572_abnormal_emotion/affect_behav0.96282625
108* MP0000358_abnormal_cell_content/0.96168860
109MP0008058_abnormal_DNA_repair0.95976512
110MP0002751_abnormal_autonomic_nervous0.95894768
111MP0002229_neurodegeneration0.95862298
112MP0004811_abnormal_neuron_physiology0.93724662
113MP0005275_abnormal_skin_tensile0.93675350
114MP0001963_abnormal_hearing_physiology0.92911866
115MP0001756_abnormal_urination0.92676524
116MP0005164_abnormal_response_to0.90783966
117MP0004484_altered_response_of0.89739173
118MP0000681_abnormal_thyroid_gland0.89599149
119MP0002090_abnormal_vision0.89044994
120MP0003121_genomic_imprinting0.88853936
121MP0006082_CNS_inflammation0.88356327
122MP0004859_abnormal_synaptic_plasticity0.88142017
123MP0002557_abnormal_social/conspecific_i0.88029149
124MP0004272_abnormal_basement_membrane0.87440747
125MP0005623_abnormal_meninges_morphology0.87200764
126MP0002233_abnormal_nose_morphology0.86173824
127MP0005253_abnormal_eye_physiology0.85987615
128MP0005187_abnormal_penis_morphology0.85730715
129MP0001486_abnormal_startle_reflex0.85589659
130MP0005551_abnormal_eye_electrophysiolog0.84888460
131MP0005248_abnormal_Harderian_gland0.84347235
132MP0003122_maternal_imprinting0.83960594
133MP0005636_abnormal_mineral_homeostasis0.83923585
134MP0002098_abnormal_vibrissa_morphology0.83798945
135MP0003329_amyloid_beta_deposits0.83714226
136MP0003633_abnormal_nervous_system0.83468388
137MP0002067_abnormal_sensory_capabilities0.83037951
138MP0009785_altered_susceptibility_to0.80985714
139MP0001177_atelectasis0.80514834
140MP0002063_abnormal_learning/memory/cond0.80337413
141MP0005535_abnormal_body_temperature0.80245293
142MP0003941_abnormal_skin_development0.78717733
143MP0001944_abnormal_pancreas_morphology0.78199533
144MP0001348_abnormal_lacrimal_gland0.77038507
145MP0000762_abnormal_tongue_morphology0.76664436
146MP0000613_abnormal_salivary_gland0.76637485
147MP0008872_abnormal_physiological_respon0.76617091
148MP0002184_abnormal_innervation0.76005123
149MP0010678_abnormal_skin_adnexa0.72668073

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.52009766
2Acute necrotizing encephalopathy (HP:0006965)4.45438806
3Hypothermia (HP:0002045)4.31823131
4Parakeratosis (HP:0001036)4.21386210
5Abnormal mitochondria in muscle tissue (HP:0008316)4.16366972
6Progressive macrocephaly (HP:0004481)3.79568683
7Mitochondrial inheritance (HP:0001427)3.56489846
8Acute encephalopathy (HP:0006846)3.55661617
9Abnormal hair whorl (HP:0010721)3.40908630
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.28362664
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.28362664
12Congenital ichthyosiform erythroderma (HP:0007431)3.21204253
13Renal Fanconi syndrome (HP:0001994)3.17876849
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95557979
15Medial flaring of the eyebrow (HP:0010747)2.92956835
16Rhinitis (HP:0012384)2.87291143
17Congenital, generalized hypertrichosis (HP:0004540)2.83140467
18Neuroendocrine neoplasm (HP:0100634)2.78872149
19Neurofibrillary tangles (HP:0002185)2.75542672
20Vacuolated lymphocytes (HP:0001922)2.73655242
21Methylmalonic acidemia (HP:0002912)2.73042533
22Vaginal atresia (HP:0000148)2.72721408
23Genital tract atresia (HP:0001827)2.71261569
24Pheochromocytoma (HP:0002666)2.70920572
25Increased CSF lactate (HP:0002490)2.70196007
26Leukodystrophy (HP:0002415)2.68348619
27Abnormal respiratory motile cilium physiology (HP:0012261)2.66278386
28Gait imbalance (HP:0002141)2.62055651
29Hepatocellular necrosis (HP:0001404)2.62048487
30Polyphagia (HP:0002591)2.61767106
31Abnormal respiratory motile cilium morphology (HP:0005938)2.58592083
32Abnormal respiratory epithelium morphology (HP:0012253)2.58592083
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56010600
34Congenital primary aphakia (HP:0007707)2.55959172
35Patchy hypopigmentation of hair (HP:0011365)2.53500889
36Lactic acidosis (HP:0003128)2.47977365
37Abnormality of renal resorption (HP:0011038)2.47847313
38Increased hepatocellular lipid droplets (HP:0006565)2.46946242
39Nephrogenic diabetes insipidus (HP:0009806)2.44668132
40White forelock (HP:0002211)2.44631616
41Abnormality of the anterior horn cell (HP:0006802)2.43005768
42Degeneration of anterior horn cells (HP:0002398)2.43005768
43Abnormality of midbrain morphology (HP:0002418)2.40858008
44Molar tooth sign on MRI (HP:0002419)2.40858008
45Hepatic necrosis (HP:0002605)2.40441472
46Tetraparesis (HP:0002273)2.34263114
47Autoamputation (HP:0001218)2.33529134
48Lipid accumulation in hepatocytes (HP:0006561)2.30587272
49Amniotic constriction ring (HP:0009775)2.26595651
50Abnormality of placental membranes (HP:0011409)2.26595651
51Increased serum lactate (HP:0002151)2.24590043
52Pancreatic cysts (HP:0001737)2.21361644
53Methylmalonic aciduria (HP:0012120)2.20608083
54Delayed gross motor development (HP:0002194)2.20475811
55Poor suck (HP:0002033)2.16404398
56Cerebral hemorrhage (HP:0001342)2.16122265
57Abnormality of glycolysis (HP:0004366)2.14269569
58Increased serum pyruvate (HP:0003542)2.14269569
59Mutism (HP:0002300)2.11975782
60Type I transferrin isoform profile (HP:0003642)2.11350167
61Optic disc pallor (HP:0000543)2.09019832
62Sensory axonal neuropathy (HP:0003390)2.08021607
63Absent/shortened dynein arms (HP:0200106)2.07431201
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.07431201
65Aplasia/Hypoplasia of the lens (HP:0008063)2.07379991
66Cerebral edema (HP:0002181)2.06979989
67Hypomagnesemia (HP:0002917)2.06343203
68Abnormality of the corticospinal tract (HP:0002492)2.05751681
69Limb dystonia (HP:0002451)2.04436964
70Segmental peripheral demyelination/remyelination (HP:0003481)2.04376063
71Renal cortical cysts (HP:0000803)2.03754916
72Abnormality of vitamin B metabolism (HP:0004340)2.02607124
73Atonic seizures (HP:0010819)2.02478143
74Abnormality of urine glucose concentration (HP:0011016)2.02435856
75Glycosuria (HP:0003076)2.02435856
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.02027531
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01895008
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01864899
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01864899
80Abnormality of methionine metabolism (HP:0010901)2.01398840
81CNS demyelination (HP:0007305)2.01385099
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.01233996
83Retinal dysplasia (HP:0007973)2.01208174
84Abnormal autonomic nervous system physiology (HP:0012332)2.00542785
85Respiratory failure (HP:0002878)2.00085690
86Lethargy (HP:0001254)1.98554641
87Symptomatic seizures (HP:0011145)1.98024085
88Popliteal pterygium (HP:0009756)1.97152989
89Renal tubular dysfunction (HP:0000124)1.97072282
903-Methylglutaconic aciduria (HP:0003535)1.95666074
91Intestinal atresia (HP:0011100)1.94755799
92Abnormal protein glycosylation (HP:0012346)1.91576530
93Abnormal glycosylation (HP:0012345)1.91576530
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91576530
95Abnormal protein N-linked glycosylation (HP:0012347)1.91576530
96Xerostomia (HP:0000217)1.91063303
97Chronic bronchitis (HP:0004469)1.90875450
98Muscular hypotonia of the trunk (HP:0008936)1.90731454
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90138143
100Dysautonomia (HP:0002459)1.87996793
101Increased IgM level (HP:0003496)1.87821509
102Stenosis of the external auditory canal (HP:0000402)1.87032903
103Hypoglycemic coma (HP:0001325)1.86808323
104Exercise intolerance (HP:0003546)1.86554530
105Hypokinesia (HP:0002375)1.86440495
106X-linked dominant inheritance (HP:0001423)1.86211660
107Hyperphosphaturia (HP:0003109)1.84438751
108Nephronophthisis (HP:0000090)1.83240218
109Abnormality of alanine metabolism (HP:0010916)1.82416797
110Hyperalaninemia (HP:0003348)1.82416797
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82416797
112Hypokalemic alkalosis (HP:0001949)1.81707879
113True hermaphroditism (HP:0010459)1.80212288
114Abnormality of calcium-phosphate metabolism (HP:0100530)1.79707313
115Chronic sinusitis (HP:0011109)1.76291826
116Erythroderma (HP:0001019)1.75325978
117Generalized aminoaciduria (HP:0002909)1.74957190
118Abnormal ciliary motility (HP:0012262)1.74102194
119Abnormality of magnesium homeostasis (HP:0004921)1.74071064
120Pancreatic fibrosis (HP:0100732)1.73885995
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73013697
122Poor coordination (HP:0002370)1.72344199
123Cupped ear (HP:0000378)1.72175092
124Hyperinsulinemic hypoglycemia (HP:0000825)1.71972956
125Nausea (HP:0002018)1.70287886
126Increased circulating renin level (HP:0000848)1.69331279
127Hypoplasia of the uterus (HP:0000013)1.69200723
128Increased intramyocellular lipid droplets (HP:0012240)1.65718283
129Thickened helices (HP:0000391)1.65397552
130Conjugated hyperbilirubinemia (HP:0002908)1.64715101
131Aplasia/hypoplasia of the uterus (HP:0008684)1.62381838
132Osteomalacia (HP:0002749)1.62331233
133Metaphyseal dysplasia (HP:0100255)1.61513453
134Humeroradial synostosis (HP:0003041)1.59612637
135Synostosis involving the elbow (HP:0003938)1.59612637
136Abnormal urine phosphate concentration (HP:0012599)1.56607270
137Exertional dyspnea (HP:0002875)1.56256893
138Recurrent corneal erosions (HP:0000495)1.56072098
139Hypoglycemic seizures (HP:0002173)1.55894582
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.54912141
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.53637757
142Metabolic alkalosis (HP:0200114)1.53418444
143Congenital sensorineural hearing impairment (HP:0008527)1.52559034
144Myokymia (HP:0002411)1.52337180
145Ulnar claw (HP:0001178)1.52141777
146Nasolacrimal duct obstruction (HP:0000579)1.51901546
147Cerebral inclusion bodies (HP:0100314)1.51239065
148Dysostosis multiplex (HP:0000943)1.50942951
149Supranuclear gaze palsy (HP:0000605)1.50691253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.93308241
2MAP4K23.68828252
3PBK3.39740082
4TRIM283.22501146
5BCR3.14309122
6LIMK12.65668386
7CASK2.63146329
8STK392.62668747
9ARAF2.52328234
10OXSR12.26212102
11BMPR1B2.25508936
12MAP3K122.12146927
13BMPR22.07478799
14MAP3K41.91482507
15BCKDK1.87379800
16MAPK151.81614705
17WNK41.81566401
18ERBB31.69717662
19INSRR1.67876137
20MET1.57077990
21PLK21.56752468
22MST1R1.53818382
23GRK71.52001365
24MAP3K21.47988376
25NTRK11.45913381
26NEK11.43239182
27FRK1.42471318
28WNK31.38689352
29MAPKAPK51.37474125
30SRPK11.34177159
31MAP3K141.33099823
32NME11.32719389
33ADRBK21.31907581
34PRKCE1.31049251
35EIF2AK11.30515072
36TRPM71.29059456
37TESK11.24864121
38AKT31.24488464
39GRK51.22353920
40STK38L1.21091620
41TSSK61.20560244
42MYLK1.18870993
43ACVR1B1.15779198
44CSNK1G31.11257404
45PKN11.10473532
46PLK31.10078695
47PNCK1.07724952
48PRPF4B1.07594396
49STK241.07279391
50BRAF1.05684515
51CAMK2B1.04053915
52SGK4941.02163013
53SGK2231.02163013
54NEK60.99964969
55BUB10.98928979
56ERBB40.96775454
57PIM20.95775634
58PAK30.94404035
59CAMK2D0.94333752
60CSNK1A1L0.91509312
61VRK10.89934108
62DYRK20.89253772
63UHMK10.89238902
64MAPK130.86199339
65IRAK20.86181998
66EPHA40.86022694
67PDK20.85898826
68NUAK10.85629060
69YES10.83905629
70TNIK0.83394167
71DYRK30.82054576
72PAK40.81452691
73FER0.79952402
74FGFR20.79119887
75CSNK1G10.78339127
76RIPK40.76106699
77FGR0.74516131
78IRAK40.73985294
79CSNK1G20.73959072
80RPS6KA40.71295099
81CAMK2A0.71056970
82MAP3K50.70382426
83PIK3CG0.69718190
84CAMK2G0.69517575
85VRK20.66589230
86ROCK20.66112815
87MKNK20.64853863
88PINK10.64077412
89EPHA20.63648840
90STK30.63300490
91BRSK20.61145336
92ADRBK10.60867131
93MAP2K40.60591928
94ZAK0.60173439
95WNK10.60099881
96NTRK30.59822013
97IRAK10.58398465
98MAP2K70.58314049
99ILK0.57876801
100TGFBR10.57874435
101MKNK10.57762223
102HIPK20.56329599
103EIF2AK30.56079867
104IKBKB0.54114394
105MAP2K10.51728824
106WEE10.51684403
107MINK10.51113566
108DAPK10.50843678
109PHKG20.50037072
110PHKG10.50037072
111STK160.49069836
112ABL20.47838375
113EPHB20.46850637
114CDK190.46788469
115CAMKK20.46702577
116PRKCQ0.46058633
117TLK10.45527777
118DAPK20.45514902
119MOS0.44954980
120PLK40.44945110
121GRK10.44332147
122EIF2AK20.43781186
123PRKCI0.40815140
124RPS6KA50.39952600
125CDK50.38935625
126TESK20.38648851
127PLK10.37540523
128PRKACA0.37515789
129CDK140.37448323
130MARK10.37196223
131SIK30.37174280
132MAP2K20.37008471
133PRKCD0.36895378
134CSNK1A10.36679958
135CCNB10.36306898
136CDK180.36120134
137EPHB10.35564506
138EPHA30.34817421
139LATS20.34474040
140RPS6KA20.32691292
141CDK30.32201375
142NME20.30376292
143PRKCG0.30087294
144SGK20.29456223
145PRKG10.29275388

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.54665955
2Oxidative phosphorylation_Homo sapiens_hsa001903.96859136
3Collecting duct acid secretion_Homo sapiens_hsa049663.09387423
4Sulfur metabolism_Homo sapiens_hsa009203.03870941
5Parkinsons disease_Homo sapiens_hsa050122.84257663
6Vibrio cholerae infection_Homo sapiens_hsa051102.71301727
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.70128709
8Alzheimers disease_Homo sapiens_hsa050102.48369363
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.40913312
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.40310905
11Fatty acid elongation_Homo sapiens_hsa000622.23427221
12Rheumatoid arthritis_Homo sapiens_hsa053232.21281454
13Proteasome_Homo sapiens_hsa030502.11596337
14Steroid biosynthesis_Homo sapiens_hsa001002.09082384
15Huntingtons disease_Homo sapiens_hsa050161.88756751
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88572863
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87859760
18Phagosome_Homo sapiens_hsa041451.81501878
19Sphingolipid metabolism_Homo sapiens_hsa006001.67343584
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.61198355
21Graft-versus-host disease_Homo sapiens_hsa053321.57268868
22Synaptic vesicle cycle_Homo sapiens_hsa047211.55646010
23Propanoate metabolism_Homo sapiens_hsa006401.54878739
24Type I diabetes mellitus_Homo sapiens_hsa049401.51927409
25Ether lipid metabolism_Homo sapiens_hsa005651.47693532
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35633468
27Serotonergic synapse_Homo sapiens_hsa047261.33772285
28Histidine metabolism_Homo sapiens_hsa003401.28923381
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26429692
30Vitamin B6 metabolism_Homo sapiens_hsa007501.21811971
31Lysosome_Homo sapiens_hsa041421.21047850
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20939633
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20384286
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19018047
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.15598891
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15522691
37Allograft rejection_Homo sapiens_hsa053301.11152589
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10867226
39Arachidonic acid metabolism_Homo sapiens_hsa005901.09598861
40Autoimmune thyroid disease_Homo sapiens_hsa053201.07679445
41Pyruvate metabolism_Homo sapiens_hsa006201.01261174
42RNA degradation_Homo sapiens_hsa030180.98310229
43Caffeine metabolism_Homo sapiens_hsa002320.97457760
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97080240
45Regulation of autophagy_Homo sapiens_hsa041400.96928696
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92203192
47Ribosome_Homo sapiens_hsa030100.90266725
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86483771
49Tyrosine metabolism_Homo sapiens_hsa003500.86299545
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84693984
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84568582
52Linoleic acid metabolism_Homo sapiens_hsa005910.81751991
53Taste transduction_Homo sapiens_hsa047420.80849418
54GABAergic synapse_Homo sapiens_hsa047270.80461416
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77373652
56Butanoate metabolism_Homo sapiens_hsa006500.77112745
57Glutathione metabolism_Homo sapiens_hsa004800.76533394
58Phenylalanine metabolism_Homo sapiens_hsa003600.75782542
59Phototransduction_Homo sapiens_hsa047440.74618214
60Asthma_Homo sapiens_hsa053100.73067435
61RNA polymerase_Homo sapiens_hsa030200.72341169
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72027324
63Prion diseases_Homo sapiens_hsa050200.71529076
64Mineral absorption_Homo sapiens_hsa049780.70633605
65Tryptophan metabolism_Homo sapiens_hsa003800.69130247
66Nucleotide excision repair_Homo sapiens_hsa034200.68715827
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68627699
68Cardiac muscle contraction_Homo sapiens_hsa042600.67842416
69Insulin secretion_Homo sapiens_hsa049110.67671479
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67591343
71beta-Alanine metabolism_Homo sapiens_hsa004100.66564731
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65753864
73Cocaine addiction_Homo sapiens_hsa050300.65557665
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65446594
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65257307
76Mismatch repair_Homo sapiens_hsa034300.63740087
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63393260
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.62972999
79Circadian rhythm_Homo sapiens_hsa047100.60805167
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59421189
81Malaria_Homo sapiens_hsa051440.59016435
82Non-homologous end-joining_Homo sapiens_hsa034500.57787505
83African trypanosomiasis_Homo sapiens_hsa051430.57594788
84Purine metabolism_Homo sapiens_hsa002300.57424164
85Other glycan degradation_Homo sapiens_hsa005110.57279410
86Dopaminergic synapse_Homo sapiens_hsa047280.57069920
87Nitrogen metabolism_Homo sapiens_hsa009100.56260818
88Pertussis_Homo sapiens_hsa051330.56137462
89Axon guidance_Homo sapiens_hsa043600.55126548
90Morphine addiction_Homo sapiens_hsa050320.54968668
91Peroxisome_Homo sapiens_hsa041460.53002049
92Amphetamine addiction_Homo sapiens_hsa050310.52135802
93Pyrimidine metabolism_Homo sapiens_hsa002400.51434401
94Arginine and proline metabolism_Homo sapiens_hsa003300.51290605
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50984752
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.49377026
97Selenocompound metabolism_Homo sapiens_hsa004500.49200385
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48061838
99Salmonella infection_Homo sapiens_hsa051320.46879954
100Chemical carcinogenesis_Homo sapiens_hsa052040.46486661
101Spliceosome_Homo sapiens_hsa030400.46435300
102Metabolic pathways_Homo sapiens_hsa011000.46266728
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46090737
104N-Glycan biosynthesis_Homo sapiens_hsa005100.45662388
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45088002
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44550430
107Oocyte meiosis_Homo sapiens_hsa041140.43405107
108RNA transport_Homo sapiens_hsa030130.42304921
109Fatty acid metabolism_Homo sapiens_hsa012120.41974385
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41830002
111Folate biosynthesis_Homo sapiens_hsa007900.41670460
112Fatty acid degradation_Homo sapiens_hsa000710.41578172
113Cholinergic synapse_Homo sapiens_hsa047250.41294418
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41149819
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40386932
116Nicotine addiction_Homo sapiens_hsa050330.39495695
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39447299
118Circadian entrainment_Homo sapiens_hsa047130.38124127
119Carbon metabolism_Homo sapiens_hsa012000.37893118
120Legionellosis_Homo sapiens_hsa051340.34723979
121Basal transcription factors_Homo sapiens_hsa030220.33477420
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33399853
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32506190
124Tight junction_Homo sapiens_hsa045300.31355721
125Long-term depression_Homo sapiens_hsa047300.31058497
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31033862
127Renin secretion_Homo sapiens_hsa049240.30976791
128Retinol metabolism_Homo sapiens_hsa008300.30347857
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30340022
130Tuberculosis_Homo sapiens_hsa051520.30248585
131Glutamatergic synapse_Homo sapiens_hsa047240.30010746
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.28968689
133Ras signaling pathway_Homo sapiens_hsa040140.25988474
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.25840483
135Pancreatic secretion_Homo sapiens_hsa049720.24915506
136Ovarian steroidogenesis_Homo sapiens_hsa049130.24225081
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23342291

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